Georges E Janssens, Marte Molenaars, Katharina Herzog, Lotte Grevendonk, Carlijn M E Remie, Martin A T Vervaart, Hyung L Elfrink, Eric J M Wever, Bauke V Schomakers, Simone W Denis, Hans R Waterham, Mia L Pras-Raves, Michel van Weeghel, Antoine H C van Kampen, Alessandra Tammaro, Loes M Butter, Sanne van der Rijt, Sandrine Florquin, Aldo Jongejan, Perry D Moerland, Joris Hoeks, Patrick Schrauwen, Frédéric M Vaz, Riekelt H Houtkooper
Studies in preclinical models suggest that complex lipids, such as phospholipids, play a role in the regulation of longevity. However, identification of universally conserved complex lipid changes that occur during aging, and how these respond to interventions, is lacking. Here, to comprehensively map how complex lipids change during aging, we profiled ten tissues in young versus aged mice using a lipidomics platform. Strikingly, from >1,200 unique lipids, we found a tissue-wide accumulation of bis(monoacylglycero)phosphate (BMP) during mouse aging...
April 12, 2024: Nature aging