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Lipidomics

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https://www.readbyqxmd.com/read/29792954/increased-brain-docosahexaenoic-acid-has-no-effect-on-the-resolution-of-neuroinflammation-following-intracerebroventricular-lipopolysaccharide-injection
#1
Marc-Olivier Trépanier, Kathryn E Hopperton, Vanessa Giuliano, Mojgan Masoodi, Richard P Bazinet
Resolution of inflammation in the periphery was once thought to be a passive process, but new research now suggests it is an active process mediated by specialized pro-resolving lipid mediators (SPM) derived from omega-3 polyunsaturated fatty acids (n-3 PUFA). However, this has yet to be illustrated in neuroinflammation. The purpose of this study was to measure resolution of neuroinflammation and to test whether increasing brain docosahexaenoic acid (DHA) affects the resolution of neuroinflammation. C57Bl/6 mice, fat-1 mice and their wildtype littermates, fed either fish oil or safflower oil, received lipopolysaccharide (LPS) in the left lateral ventricle...
May 21, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29792796/nano-lc-nsi-ms-refines-lipidomics-by-enhancing-lipid-coverage-measurement-sensitivity-and-linear-dynamic-range
#2
Niklas Danne-Rasche, Cristina Coman, Robert Ahrends
Nano-liquid chromatography (nLC) - nano-electrospray (NSI) is one of the cornerstones of mass spectrometry based bioanalytics. Nevertheless, the application of nLC is not prevailing lipid analyses so far. In this study, we established a reproducible nLC separation for global lipidomics and describe the merits of using such a miniaturized system for lipid analyses. In order to enable comprehensive lipid analyses that is not restricted to specific lipid classes, we particularly optimized sample preparation conditions and reversed phase separation parameters...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29789665/existing-and-novel-biomarkers-for-precision-medicine-in-systemic-sclerosis
#3
REVIEW
Peter J Wermuth, Sonsoles Piera-Velazquez, Joel Rosenbloom, Sergio A Jimenez
The discovery and validation of biomarkers resulting from technological advances in the analysis of genomic, transcriptomic, lipidomic and metabolomic pathways involved in the pathogenesis of complex human diseases have led to the development of personalized and rationally designed approaches for the clinical management of such disorders. Although some of these approaches have been applied to systemic sclerosis (SSc), an unmet need remains for validated, non-invasive biomarkers to aid in the diagnosis of SSc, as well as in the assessment of disease progression and response to therapeutic interventions...
May 22, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29787912/high-fat-diet-induced-lipidome-perturbations-in-the-cortex-hippocampus-hypothalamus-and-olfactory-bulb-of-mice
#4
Jong Cheol Lee, Se Mi Park, Il Yong Kim, Hyerim Sung, Je Kyung Seong, Myeong Hee Moon
Given their important role in neuronal function, there has been an increasing focus on altered lipid levels in brain disorders. The effect of a high-fat (HF) diet on the lipid profiles of the cortex, hippocampus, hypothalamus, and olfactory bulb of the mouse brain was investigated using nanoflow ultrahigh pressure liquid chromatography-electrospray ionization-tandem mass spectrometry in the current study. For 8 weeks, two groups of 5-week-old mice were fed either an HF or normal diet (6 mice from each group analyzed as the F and N groups, respectively)...
May 19, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29786969/hippocampal-lipidome-and-transcriptome-profile-alterations-triggered-by-acute-exposure-of-mice-to-gsm-1800-mhz-mobile-phone-radiation-an-exploratory-study
#5
Adamantia F Fragopoulou, Alexandros Polyzos, Maria-Despoina Papadopoulou, Anna Sansone, Areti K Manta, Evangelos Balafas, Nikolaos Kostomitsopoulos, Aikaterini Skouroliakou, Chryssostomos Chatgilialoglu, Alexandros Georgakilas, Dimitrios J Stravopodis, Carla Ferreri, Dimitris Thanos, Lukas H Margaritis
BACKGROUND: The widespread use of wireless devices during the last decades is raising concerns about adverse health effects of the radiofrequency electromagnetic radiation (RF-EMR) emitted from these devices. Recent research is focusing on unraveling the underlying mechanisms of RF-EMR and potential cellular targets. The "omics" high-throughput approaches are powerful tools to investigate the global effects of RF-EMR on cellular physiology. METHODS: In this work, C57BL/6 adult male mice were whole-body exposed (nE xp  = 8) for 2 hr to GSM 1800 MHz mobile phone radiation at an average electric field intensity range of 4...
May 22, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29786091/automated-parallel-mass-spectrometry-imaging-and-structural-identification-of-lipids
#6
Shane R Ellis, Martin R L Paine, Gert B Eijkel, Josch K Pauling, Peter Husen, Mark W Jervelund, Martin Hermansson, Christer S Ejsing, Ron M A Heeren
We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment. The method does not increase the total image acquisition time and is combined with automatic structural assignments. This lipidome-per-pixel approach automatically identified and validated 104 unique molecular lipids and their spatial locations from rat cerebellar tissue.
May 21, 2018: Nature Methods
https://www.readbyqxmd.com/read/29784642/identification-of-key-lipids-critical-for-platelet-activation-by-comprehensive-analysis-of-the-platelet-lipidome
#7
Bing Peng, Sascha Geue, Cristina Coman, Patrick Münzer, Dominik Kopczynski, Canan Has, Nils Hoffmann, Mailin-Christin Manke, Florian Lang, Albert Sickmann, Meinrad Gawaz, Oliver Borst, Robert Ahrends
Platelet integrity and function critically depend on lipid composition. However, the lipid inventory in platelets was hitherto not quantified. Here, we examined the lipidome of murine platelets using lipid-category tailored protocols on a quantitative lipidomics platform. We could show that the platelet lipidome comprises almost 400 lipid species and covers a concentration range of seven orders of magnitude. A systematic comparison of the lipidomics network in resting and activated murine platelets, validated in human platelets, revealed that less than 20% of the platelet lipidome is changed upon activation, involving mainly lipids containing arachidonic acid...
May 21, 2018: Blood
https://www.readbyqxmd.com/read/29783268/lipidomic-components-alterations-of-human-follicular-fluid-reveal-the-relevance-of-improving-clinical-outcomes-in-women-using-progestin-primed-ovarian-stimulation-compared-to-short-term-protocol
#8
Xiaowei Wen, Yanping Kuang, Lixia Zhou, Baofeng Yu, Qiuju Chen, Yonglun Fu, Zheng Yan, Haiyan Guo, Qifeng Lyu, Jun Xie, Weiran Chai
BACKGROUND Increasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty of clinicians that has made many seek a variety of protocols. This study was undertaken to use a liquid chromatography-mass spectrometry (LC-MS) to define the alterations of follicular fluid (FF) lipid metabolites in patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between the differentially expressed lipids and ameliorative clinical outcomes...
May 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29782274/-dysfunctional-high-density-lipoproteins-role-in-atherogenesis-and-potential-targets-for-phospholipid-therapy
#9
T I Torchovskaya, V A Kudinov, T S Zakharova, S S Markin
In recent years the number of articles on damages of high-density lipoproteins (HDL) properties in patients with atherosclerosis has sharply increased. First, it concerns their ability to accept cholesterol (CH) from macrophages - the basis of antiatherogenic action of HDL. This ability was assessed ex vivo - by activity of cell cholesterol (CH) efflux to HDL or into patient's serum. In many works inverse relationship was shown between CH acceptor capacity of HDL and severity of atherosclerotic disease or frequency of its exacerbations during long-term observation, independent from HDL CH concentration...
March 2018: Kardiologiia
https://www.readbyqxmd.com/read/29778532/non-alcoholic-fatty-liver-disease-insights-from-sphingolipidomics
#10
David J Montefusco, Jeremy C Allegood, Sarah Spiegel, L Ashley Cowart
Non-alcoholic fatty liver disease (NAFLD) is a major clinical concern and its treatment consumes abundant resources. While accumulation of lipids in hepatocytes initiates the disease, this in itself is not necessarily harmful; rather, initiation of inflammation and subsequent fibrosis and cirrhosis are critical steps in NAFLD pathology. Mechanisms linking lipid overload to downstream disease progression are not fully understood; however, bioactive lipid metabolism may underlie instigation of proinflammatory signaling...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29774984/comments-on-recent-reports-on-infrared-spectral-detection-of-disease-markers-in-blood-components
#11
Max Diem
The search for disease markers in whole blood, or easily accessible blood components by spectral methods is a highly important aspect in the field of biophotonic research for disease diagnostics and screening, since it promises a minimally invasive approach to assess an individual's state of health. Fourier transform infrared spectroscopy, in particular, promises to be a fast, inexpensive method to search for markers of disease, since it detects variation in the proteome, lipidome and metabolome of biofluids, or activation of immune cells...
May 18, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29773840/rna-seq-and-uhplc-q-tof-ms-based-lipidomics-study-in-lysiphlebia-japonica
#12
Xueke Gao, Junyu Luo, Limin Lü, LiJuan Zhang, Shuai Zhang, Jinjie Cui
Lipids play an important role in energy storage, membrane structure stabilization and signaling. Parasitoids are excellent models to study lipidomics because a majority of them do not accumulate during their free-living life-stage. Studies on parasitoids have mostly focused on the changes in the lipids and gene transcripts in hosts and little attention has been devoted to lipidomics and transcriptomics changes in parasitoids. In this study, a relative quantitative analysis of lipids and their gene transcripts in 3-days-old Lysiphlebia japonica larva (3 days after spawning) and pupae were performed using liquid chromatography, mass spectrometry and RNA-seq...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765489/gallic-acid-l-leucine-conjugate-protects-mice-against-lps-induced-inflammation-and-sepsis-via-correcting-proinflammatory-lipid-mediator-profiles-and-oxidative-stress
#13
Yuanyuan Cheng, Xuechen Li, Hung-Fat Tse, Jianhui Rong
The pathology of endotoxin LPS-induced sepsis is hallmarked by aberrant production of proinflammatory lipid mediators and nitric oxide (NO). The aim of the present study was to determine whether the new product gallic acid-L-leucine (GAL) conjugate could ameliorate the LPS-induced dysregulation of arachidonic acid metabolism and NO production. We first investigated the effects of GAL conjugate on the expression of proinflammatory enzymes and the production of proinflammatory NO and lipid mediators in mouse macrophage cell line RAW264...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29762743/lipidome-evolution-in-mammalian-tissues
#14
Ekaterina Khrameeva, Ilia Kurochkin, Katarzyna Bozek, Patrick Giavalisco, Philipp Khaitovich
Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, less than two percent of the lipidome evolves this way. Yet, lipids constituting this two percent cluster in specific functions shared among all tissues...
May 11, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29761437/plant-lipidomics-using-uplc-qtof-ms
#15
Yozo Okazaki, Kazuki Saito
Lipids are primary metabolites used for energy storage, signal transduction, and pigmentation, besides being common membrane components. Considering the importance of comprehensive lipid analysis (lipidomics) for a detailed understanding of cellular metabolic states, this chapter introduces liquid chromatography-quadrupole time-of-flight mass spectrometry as a powerful untargeted plant lipidomics technique.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761436/semi-targeted-lipidomics-of-plant-acyl-lipids-using-uplc-hr-ms-in-combination-with-a-data-independent-acquisition-mode
#16
Mohamed A Salem, Patrick Giavalisco
In recent years, multiple mass-spectrometric methods have been developed to tackle fundamental analytical questions in the field of biology and biochemistry. One essential approach relies on the use of liquid chromatography (LC), for efficient compound separation, coupled to high-resolution mass spectrometry (HR-MS). Even though these techniques are highly sensitive allowing for the reliable measurement of several thousand mass features, the major bottleneck is to convert the measured masses into annotated lipid species...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761435/extraction-of-plant-lipids-for-lc-ms-based-untargeted-plant-lipidomics
#17
Thusitha W T Rupasinghe, Ute Roessner
Lipids are defined as hydrophobic or amphipathic small molecules which consist of a number of structurally and functionally distinct molecules that span from nonpolar to neutral to polar compounds. Lipidomics is the comprehensive analysis of all lipids in a biological system. Changes in lipid metabolism and composition, as well as of distinct lipid species have been linked with altered plant growth, development, and responses to environmental stresses including salinity. Recently, improved liquid chromatography mass spectrometry (LC-MS)-based techniques have provided the rapid expansion of lipidomics research...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29760920/serum-lipidomics-of-bovine-paratuberculosis-disruption-of-choline-containing-glycerophospholipids-and-sphingolipids
#18
Paul L Wood, Erdal Erol, Glen F Hoffsis, Margaret Steinman, Jeroen DeBuck
Objectives: Bovine paratuberculosis is a devastating infection with Mycobacterium avium subspecies paratuberculosis that ultimately results in death from malnutrition. While the infection is characterized by a long (2-4 years) subclinical phase with immune activation, ultimately host defense mechanisms fail and the bacteria spread from the small intestine to other organs. Since both the gastrointestinal tract and liver are essential for the biosynthesis of structural glycerophospholipids, we investigated the circulating levels of these lipids in field infections and experimentally infected cattle...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29759594/liquid-chromatography-mass-spectrometry-based-metabolomics-and-lipidomics-reveal-toxicological-mechanisms-of-bisphenol-f-in-breast-cancer-xenografts
#19
Chao Zhao, Peisi Xie, Hailin Wang, Zongwei Cai
Bisphenol F (BPF) is a major alternative to bisphenol (BPA) and has been widely used. Although BPA exposure is known to generate various toxic effects, toxicity of BPF remains under-explored. A comprehensive method involving mass spectrometry (MS)-based global lipidomics and metabolomics, and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI)- MS imaging (MSI) was used to study toxic effects of BPF and the underlying mechanisms on tumor metastasis-related tissues (liver and kidney) in breast cancer xenografts...
May 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29758358/lipidomic-signature-of-serum-from-the-rats-exposed-to-alcohol-for-one-year
#20
Hongchun Li, Wei Xu, Linhong Jiang, Hui Gu, Menglu Li, Jiamei Zhang, Wei Guo, Pengchi Deng, Hailei Long, Qian Bu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Alcohol abuse and its related diseases are the major risk factors for human health. Although the mechanism of alcohol-related disorders has been widely investigated, serum metabolites associated with long-term alcohol intake have not been well explored. In this study, we aimed to investigate the profiles of serum metabolites and lipid species of rats chronically exposed to alcohol, which may be involved in the pathogenesis of alcohol-associated disease. An 1 H NMR-based metabolomics and Q-TOF/MS-based lipidomics approach were applied to investigate the profile of serum metabolites and lipid species of rats administrated daily with alcohol (12% vol/vol, 10 ml/kg per day, i...
May 11, 2018: Toxicology Letters
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