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https://www.readbyqxmd.com/read/28936395/antioxidative-activity-of-high-density-lipoprotein-hdl-mechanistic-insights-into-potential-clinical-benefit
#1
REVIEW
Fernando Brites, Maximiliano Martin, Isabelle Guillas, Anatol Kontush
Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in the development of atherosclerotic plaques, leading to the foam cell formation. Chemical modification of LDL is however necessary to induce this process. Proatherogenic LDL modifications include aggregation, enzymatic digestion and oxidation. LDL oxidation by one-electron (free radicals) and two-electron oxidants dramatically increases LDL affinity to macrophage scavenger receptors, leading to rapid LDL uptake and fatty streak formation...
December 2017: BBA Clinical
https://www.readbyqxmd.com/read/28935855/establishing-multiple-omics-baselines-for-three-southeast-asian-populations-in-the-singapore-integrative-omics-study
#2
Woei-Yuh Saw, Erwin Tantoso, Husna Begum, Lihan Zhou, Ruiyang Zou, Cheng He, Sze Ling Chan, Linda Wei-Lin Tan, Lai-Ping Wong, Wenting Xu, Don Kyin Nwe Moong, Yenly Lim, Bowen Li, Nisha Esakimuthu Pillai, Trevor A Peterson, Tomasz Bielawny, Peter J Meikle, Piyushkumar A Mundra, Wei-Yen Lim, Ma Luo, Kee-Seng Chia, Rick Twee-Hee Ong, Liam R Brunham, Chiea-Chuen Khor, Heng Phon Too, Richie Soong, Markus R Wenk, Peter Little, Yik-Ying Teo
The Singapore Integrative Omics Study provides valuable insights on establishing population reference measurement in 364 Chinese, Malay, and Indian individuals. These measurements include > 2.5 millions genetic variants, 21,649 transcripts expression, 282 lipid species quantification, and 284 clinical, lifestyle, and dietary variables. This concept paper introduces the depth of the data resource, and investigates the extent of ethnic variation at these omics and non-omics biomarkers. It is evident that there are specific biomarkers in each of these platforms to differentiate between the ethnicities, and intra-population analyses suggest that Chinese and Indians are the most biologically homogeneous and heterogeneous, respectively, of the three groups...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935446/mitochondrial-adaptation-in-steatotic-mice
#3
Claudia Einer, Simon Hohenester, Ralf Wimmer, Lena Wottke, Renate Artmann, Sabine Schulz, Christian Gosmann, Alisha Simmons, Christin Leitzinger, Carola Eberhagen, Sabine Borchard, Sabine Schmitt, Stefanie M Hauck, Christine von Toerne, Martin Jastroch, Ellen Walheim, Christian Rust, Alexander L Gerbes, Bastian Popper, Doris Mayr, Max Schnurr, Angelika M Vollmar, Gerald Denk, Hans Zischka
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium...
September 18, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28933423/omega-3-pufa-ameliorates-hyperhomocysteinemia-induced-hepatic-steatosis-in-mice-by-inhibiting-hepatic-ceramide-synthesis
#4
Yong-Qiang Dong, Xing-Zhong Zhang, Lu-Lu Sun, Song-Yang Zhang, Bo Liu, Hui-Ying Liu, Xian Wang, Chang-Tao Jiang
Hyperhomocysteinemia (HHcy) is a key risk factor in hepatic steatosis. In this study, we applied a metabolomic approach to investigate the changes in the metabolite profile due to HHcy-induced hepatic steatosis and the effects of omega-3 PUFA (polyunsaturated fatty acid) supplementation in mice. HHcy was induced in mice by giving DL-Hcy (1.8 g/L) in drinking water for 6 weeks, then the mice were sacrificed, and the metabolic profiles of the liver and plasma were analyzed through UPLC-ESI-QTOFMS-based lipidomics...
September 21, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28927226/female-clock%C3%AE-19-%C3%AE-19-mice-are-protected-from-the-development-of-age-dependent-cardiomyopathy
#5
Faisal J Alibhai, Cristine J Reitz, Willem T Peppler, Poulami Basu, Paul Sheppard, Elena Choleris, Marica Bakovic, Tami A Martino
Aims: Circadian rhythms are important for healthy cardiovascular physiology and they are regulated by the molecular circadian mechanism. Previously, we showed that disruption of the circadian mechanism factor CLOCK in male Clock Δ19/Δ19 mice led to development of age-dependent cardiomyopathy. Here, we investigate the role of biological sex in protecting against heart disease in aging female Clock Δ19/Δ19 mice. Methods and results: Female Clock Δ19/Δ19 mice are protected from the development of cardiomyopathy with age, as heart structure and function are similar to 18 months of age versus female WT mice...
September 12, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28918859/a-preliminary-study-of-bipolar-disorder-type-i-by-mass-spectrometry-based-serum-lipidomics
#6
Henrique C Ribeiro, Aline Klassen, Mariana Pedrini, Michelle S Carvalho, Lucas B Rizzo, Mariane N Noto, Maiara Zeni-Graiff, Sumit Sethi, Francisco A H Fonseca, Ljubica Tasic, Mirian A F Hayashi, Quirino Cordeiro, Elisa Brietzke, Alessandra Sussulini
The present study aimed at investigating possible alterations in the serum lipid profile of euthymic patients with bipolar disorder type I (BD) compared to healthy controls (HC). Thirty-five individuals from both genders were recruited, with 14 diagnosed and treated as BD patients (BD group) and 21 healthy subjects (HC group). Clinical assessment was based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Young Mania Rating Scale (YMRS), and 17-items of Hamilton Depression Rating Scale (HDRS-17) data, which were used to confirm diagnosis, to verify psychiatric comorbidities, and to estimate the severity of manic and depressive symptoms...
August 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28911967/applications-of-nuclear-magnetic-resonance-in-lipid-analyses-an-emerging-powerful-tool-for-lipidomics-studies
#7
REVIEW
Jingbo Li, Thomas Vosegaard, Zheng Guo
The role of lipids in cell, tissue, and organ physiology is crucial; as many diseases, including cancer, diabetes, neurodegenerative, and infectious diseases, are closely related to absorption and metabolism of lipids. Mass spectrometry (MS) based methods are the most developed powerful tools to study the synthetic pathways and metabolic networks of cellular lipids in biological systems; leading to the birth of an emerging subject lipidomics, which has been extensively reviewed. Nuclear magnetic resonance (NMR), another powerful analytical tool, which allows the visualization of single atoms and molecules, is receiving increasing attention in lipidomics analyses...
September 11, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28911799/effects-of-glucocorticoids-on-stratum-corneum-lipids-and-function-in-human-skin-a-detailed-lipidomic-analysis
#8
Mads A Røpke, Cristina Alonso, Sora Jung, Hanne Norsgaard, Claudia Richter, Maxim E Darvin, Thomas Litman, Annika Vogt, Jürgen Lademann, Ulrike Blume-Peytavi, Jan Kottner
BACKGROUND: Topical glucocorticoids (GCs) are known to induce atrophy of human skin including thinning of epidermal and dermal compartments by influencing keratinocyte proliferation and synthesis of extracellular matrix proteins. GCs are also known to reduce skin barrier integrity but little is known about the changes in lipid composition in human skin following topical administration of GCs. OBJECTIVE: This study investigated the effects of GCs on stratum corneum (SC) function and lipid profile of human skin in vivo...
August 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28904377/kleptoplasty-does-not-promote-major-shifts-in-the-lipidome-of-macroalgal-chloroplasts-sequestered-by-the-sacoglossan-sea-slug-elysia-viridis
#9
Felisa Rey, Elisabete da Costa, Ana M Campos, Paulo Cartaxana, Elisabete Maciel, Pedro Domingues, M Rosário M Domingues, Ricardo Calado, Sónia Cruz
Sacoglossan sea slugs, also known as crawling leaves due to their photosynthetic activity, are highly selective feeders that incorporate chloroplasts from specific macroalgae. These "stolen" plastids - kleptoplasts - are kept functional inside animal cells and likely provide an alternative source of energy to their host. The mechanisms supporting the retention and functionality of kleptoplasts remain unknown. A lipidomic mass spectrometry-based analysis was performed to study kleptoplasty of the sacoglossan sea slug Elysia viridis fed with Codium tomentosum...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903958/can-changes-in-the-plasma-lipidome-help-explain-the-cardiovascular-benefits-of-the-mediterranean-diet
#10
Archna Bajaj, Daniel J Rader
No abstract text is available yet for this article.
September 13, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28903038/lipidomic-and-transcriptomic-basis-of-lysosomal-dysfunction-in-progranulin-deficiency
#11
Bret M Evers, Carlos Rodriguez-Navas, Rachel J Tesla, Janine Prange-Kiel, Catherine R Wasser, Kyoung Shin Yoo, Jeffrey McDonald, Basar Cenik, Thomas A Ravenscroft, Florian Plattner, Rosa Rademakers, Gang Yu, Charles L White, Joachim Herz
Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. Here, we show that PGRN is involved in lysosomal homeostasis and lipid metabolism. PGRN deficiency alters lysosome abundance and morphology in mouse neurons. Using an unbiased lipidomic approach, we found that brain lipid composition in humans and mice with PGRN deficiency shows disease-specific differences that distinguish them from normal and other pathologic groups...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28902579/effect-of-liver-histopathology-on-islet-cell-engraftment-in-the-model-mimicking-autologous-islet-cell-transplantation
#12
Chirag S Desai, Khalid M Khan, Xiaobo Ma, Henghong Li, Juan Wang, Lijuan Fan, Guoling Chen, Jill P Smith, Wanxing Cui
BACKGROUND: The inflammatory milieu in the liver as determined by histopathology is different in individual patients undergoing autologous islet cell transplantation. We hypothesized that inflammation related to fatty-liver adversely impacts islet survival. To test this hypothesis, we used a mouse model of fatty-liver to determine the outcome of syngeneic islet transplantation after chemical pancreatectomy. METHODS: Mice (C57BL/6) were fed a high-fat-diet from 6 weeks of age until attaining a weight of ≥28 grams (6-8 weeks) to produce a fatty liver (histologically > 30% fat);steatosis was confirmed with lipidomic profile of liver tissue...
September 13, 2017: Islets
https://www.readbyqxmd.com/read/28901891/dietary-intake-of-fat-and-fibre-according-to-reference-values-relates-to-higher-gut-microbiota-richness-in-overweight-pregnant-women
#13
Henna Röytiö, Kati Mokkala, Tero Vahlberg, Kirsi Laitinen
The diet-microbiota-metabolism relationships during pregnancy are mostly unknown. We explored the effect of the habitual diet and adherence to the dietary reference values on gut microbiota composition and diversity. Further, the association of gut microbiota with serum lipidomics and low-grade inflammation was evaluated. Overweight and obese women (BMI 30·7 (sd 4·4) kg/m2, n 100) were studied at early pregnancy (≤17 weeks). Intakes of nutrients were calculated from 3-d food diaries. Faecal microbiota composition was analysed using 16S rRNA gene sequencing...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28894173/lipidomes-of-lung-cancer-and-tumour-free-lung-tissues-reveal-distinct-molecular-signatures-for-cancer-differentiation-age-inflammation-and-pulmonary-emphysema
#14
Lars F Eggers, Julia Müller, Chakravarthy Marella, Verena Scholz, Henrik Watz, Christian Kugler, Klaus F Rabe, Torsten Goldmann, Dominik Schwudke
Little is known about the human lung lipidome, its variability in different physiological states, its alterations during carcinogenesis and the development of pulmonary emphysema. We investigated how health status might be mirrored in the lung lipidome. Tissues were sampled for both lipidomic and histological analysis. Using a screening approach, we characterised lipidomes of lung cancer tissues and corresponding tumour-free alveolar tissues. We quantified 311 lipids from 11 classes in 43 tissue samples from 26 patients...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890136/identification-of-lipidomic-markers-of-chronic-3-3-4-4-5-pentachlorobiphenyl-pcb-126-exposure-in-the-male-rat-liver
#15
Izabela Kania-Korwel, Xianai Wu, Kai Wang, Hans-Joachim Lehmler
Exposure to PCB 126, an environmentally relevant aryl hydrocarbon receptor agonist, is an environmental factor causing hepatic steatosis in rodent models; however, the lipidome of PCB 126-exposed rats has not been investigated in-depth. The objective of the present study was therefore to characterize dose-dependent changes in the lipid profile in the liver of male Sprague-Dawley rats exposed to PCB 126. Rats were exposed for three month to intraperitoneal injections of 0.01, 0.05 and 0.2μmol/kg bw PCB 126 in corn oil...
September 7, 2017: Toxicology
https://www.readbyqxmd.com/read/28888701/direct-mass-spectrometry-differentiation-of-ectopic-and-eutopic-endometrium-in-patients-with-endometriosis
#16
Leila Adamyan, Natalia Starodubtseva, Anna Borisova, Assia Stepanian, Vitaliy Chagovets, Dinara Salimova, Zhihao Wang, Alexey Kononikhin, Igor Popov, Anna Bugrova, Konstantin Chingin, Andrey Kozachenko, Huanwen Chen, Vladimir Frankevich
STUDY OBJECTIVE: To introduce a method for rapid assessment of endometriotic tissues using direct mass spectrometry (MS)-based lipidomics. DESIGN: Prospective observational cohort study. DESIGN CLASSIFICATION: II 2. SETTING: Department of Operative Gynecology of the Research Centre for Obstetrics, Gynecology and Perinatology. PATIENTS: Fifty patients with ovarian cysts and peritoneal endometriosis who underwent laparoscopic surgery between 2014 and 2016...
September 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28887514/dormant-5-lipoxygenase-in-inflammatory-macrophages-is-triggered-by-exogenous-arachidonic-acid
#17
Carlos A Sorgi, Simona Zarini, Sarah A Martin, Raphael L Sanchez, Rodrigo F Scandiuzzi, Miguel A Gijón, Carlos Guijas, Nicolas Flamand, Robert C Murphy, Lucia H Faccioli
The differentiation of resident tissue macrophages from embryonic precursors and that of inflammatory macrophages from bone marrow cells leads to macrophage heterogeneity. Further plasticity is displayed through their ability to be polarized as subtypes M1 and M2 in a cell culture microenvironment. However, the detailed regulation of eicosanoid production and its involvement in macrophage biology remains unclear. Using a lipidomics approach, we demonstrated that eicosanoid production profiles between bone marrow-derived (BMDM) and peritoneal macrophages differed drastically...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883994/lipidomics-of-human-umbilical-cord-serum-identification-of-unique-sterol-sulfates
#18
Paul L Wood, Heli Siljander, Mikael Knip
AIM: There are currently limited lipidomics data for human umbilical cord blood. Therefore, the lipidomes of cord sera from six newborns and sera from six nonpregnant females were compared. MATERIALS & METHODS: Sera lipidomics analyses were conducted using a high-resolution mass spectrometry analytical platform. RESULTS: Cord serum contained a diverse array of glycerophospholipids, albeit generally at lower concentrations than monitored in adult serum...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28883484/astrocytes-and-oligodendrocytes-in-grey-and-white-matter-regions-of-the-brain-metabolize-fatty-acids
#19
Kristina Hofmann, Rosalia Rodriguez-Rodriguez, Anne Gaebler, Núria Casals, Anja Scheller, Lars Kuerschner
The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell types. While the major function of oligodendrocytes is the formation of the lipid-rich myelin structure, the heterogeneous group of astrocytes fulfils a multitude of important roles in cerebral development and homeostasis. Brain lipid homeostasis involves the synthesis of a specific cerebral lipidome by local lipid metabolism...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882640/toxicity-of-the-main-electronic-cigarette-components-propylene-glycol-glycerin-and-nicotine-in-sprague-dawley-rats-in-a-90-day-oecd-inhalation-study-complemented-by-molecular-endpoints
#20
Blaine Phillips, Bjoern Titz, Ulrike Kogel, Danilal Sharma, Patrice Leroy, Yang Xiang, Grégory Vuillaume, Stefan Lebrun, Davide Sciuscio, Jenny Ho, Catherine Nury, Emmanuel Guedj, Ashraf Elamin, Marco Esposito, Subash Krishnan, Walter K Schlage, Emilija Veljkovic, Nikolai V Ivanov, Florian Martin, Manuel C Peitsch, Julia Hoeng, Patrick Vanscheeuwijck
While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in separate studies, limited data on the inhalation toxicity of them is available when in mixtures. In this 90-day subchronic inhalation study, Sprague-Dawley rats were nose-only exposed to filtered air, nebulized vehicle (saline), or three concentrations of PG/VG mixtures, with and without nicotine. Standard toxicological endpoints were complemented by molecular analyses using transcriptomics, proteomics, and lipidomics...
September 5, 2017: Food and Chemical Toxicology
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