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https://www.readbyqxmd.com/read/27241814/vogt-koyanagi-harada-disease
#1
Ghazala A Datoo O'Keefe, Narsing A Rao
Vogt-Koyanagi-Harada disease, a severe bilateral granulomatous intraocular inflammation associated with serous retinal detachments, disk edema, and vitritis, with eventual development of a sunset glow fundus, is an autoimmune inflammatory condition mediated by T cells that target melanocytes in individuals susceptible to the disease. Vogt-Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, uveitic, convalescent, and recurrent, with extraocular manifestations including headache, meningismus, hearing loss, poliosis, and vitiligo, to varying degrees...
May 27, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27157148/retinal-astrocytic-hamartoma-arises-in-nerve-fiber-layer-and-shows-moth-eaten-optically-empty-spaces-on-optical-coherence-tomography
#2
Carol L Shields, Emil A T Say, Timothy Fuller, Saurabh Arora, Wasim A Samara, Jerry A Shields
PURPOSE: To evaluate the specific spectral-domain (SD) optical coherence tomography (OCT) features of retinal astrocytic hamartoma (RAH) and the relationship of these features with tumor size and location. DESIGN: Retrospective case series. PARTICIPANTS: Forty-seven eyes of 42 patients with RAH. METHODS: All patients with clinically confirmed RAH were imaged with fundus photography and SD OCT. MAIN OUTCOME MEASURES: Precise OCT location of RAH features and the relationship of patient age, visual acuity, tumor size, and tumor location to the presence and size of intralesional optically empty spaces (OESs), appearing as so-called moth-eaten spaces...
August 2016: Ophthalmology
https://www.readbyqxmd.com/read/27041286/-optic-disc-drusen-and-their-complications
#3
H Štrofová, A Jarošová
UNLABELLED: The aim of the study was to analyze the group of patients with optic disc drusen focusing on possible complications of this disease. MATERIAL AND METHODS: In our group of patients, we examined 46 eyes of 23 patients with the suspicion of optic disc drusen during the period from May 2013 until January 2014. In all adult patients, we examined the anterior and posterior segment of the eye biomicroscopically, established the visual acuity, measured the intraocular pressure, examined the visual field, performed the ultrasound examination of the eye (A and B-scan), analyzed the retinal nerve fiber layer (RNFL) by means of optic coherence tomography (OCT), and color and red-free photography...
February 2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/27023703/new-findings-in-diabetic-maculopathy-and-proliferative-disease-by-swept-source-optical-coherence-tomography-angiography
#4
Paulo E Stanga, Alessandro Papayannis, Emmanouil Tsamis, Francesco Stringa, Tim Cole, Yvonne D'Souza, Assad Jalil
PURPOSE: To describe the optical coherence tomography (OCT) angiography (OCTA) features of diabetic retinopathy. METHODS: Retrospective serial case reports were examined of patients who underwent routine clinical examination and OCTA with both DRI OCT Atlantis prototype and Triton Swept-Source OCT of the posterior pole and mid-periphery. When considered necessary, fluorescein fundus angiography (FFA) with OPTOS California wide-field imaging was performed. The findings were compared with the current literature...
2016: Developments in Ophthalmology
https://www.readbyqxmd.com/read/26953028/advances-in-retinal-imaging-for-diabetic-retinopathy-and-diabetic-macular-edema
#5
Colin Siang Hui Tan, Milton Cher Yong Chew, Louis Wei Yi Lim, Srinivas R Sadda
Diabetic retinopathy and diabetic macular edema (DME) are leading causes of blindness throughout the world, and cause significant visual morbidity. Ocular imaging has played a significant role in the management of diabetic eye disease, and the advent of advanced imaging modalities will be of great value as our understanding of diabetic eye diseases increase, and the management options become increasingly varied and complex. Color fundus photography has established roles in screening for diabetic eye disease, early detection of progression, and monitoring of treatment response...
January 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/26868753/ocular-outcomes-comparison-between-14-and-70-day-head-down-tilt-bed-rest
#6
COMPARATIVE STUDY
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
PURPOSE: To compare ocular outcomes in healthy subjects undergoing 14- and/or 70-day head-down-tilt (HDT) bed rest (BR). METHODS: Participants were selected by using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects maintained a 6° HDT position for 14 and/or 70 consecutive days. Weekly ophthalmologic examinations were performed in the sitting (pre/post-BR only) and HDT positions. Mixed-effects linear models compared pre- and post-HDT BR observations between 14- and 70-day HDT BR in best-corrected visual acuity, spherical equivalent, intraocular pressure (IOP), Spectralis OCT retinal nerve fiber layer thickness, peripapillary and macular retinal thicknesses...
February 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26580572/change-of-retinal-nerve-layer-thickness-in-non-arteritic-anterior-ischemic-optic-neuropathy-revealed-by-fourier-domain-optical-coherence-tomography
#7
Mei Han, Chen Zhao, Quan-Hong Han, Shiyong Xie, Yan Li
PURPOSE: To examine the changes of non-arteritic anterior ischemic optic neuropathy (NAION) by serial morphometry using Fourier domain optical coherence tomography (FD-OCT). MATERIALS AND METHODS: Retrospective study in patients with newly diagnosed NAION (n=33, all unilateral) and controls (n=75 unilateral NAION patients with full contralateral eye vision) who underwent FD-OCT of the optic disk, optic nerve head (ONH), and macula within 1 week of onset and again 1, 3, 6, and 12 months later...
August 2016: Current Eye Research
https://www.readbyqxmd.com/read/26535468/optic-nerve-sheath-melanoma-presenting-as-a-central-retinal-vein-occlusion
#8
Alexander Barash, Patrick A Sibony, Nigel A Stippa, Nariman S Boyle, James E Davis
A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma...
March 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/26526593/linezolid-induced-retinopathy
#9
Dae Hyun Park, Tae Kwann Park, Young-Hoon Ohn, Jong Sook Park, Jee Ho Chang
PURPOSE: While optic neuropathy is a well-known cause of visual disturbances in linezolid-treated patients, the possibility of linezolid-related retinopathy has not been investigated. Here, we report a case of retinopathy demonstrated by multifocal electroretinogram (mfERG) in a linezolid-treated patient. METHOD AND RESULTS: A 61-year-old man with extensively drug-resistant pulmonary tuberculosis treated with linezolid for 5 months presented with painless loss of vision in both eyes...
December 2015: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/26444402/optical-coherence-tomography-for-the-neurologist
#10
REVIEW
Rachel C Nolan, Kannan Narayana, Steven L Galetta, Laura J Balcer
Optical coherence tomography (OCT) is a relatively new technology that is now routinely and very widely used by ophthalmologists for structural documentation of the optic nerve and retina. In neuro-ophthalmology and neurology, the value of OCT is ever expanding; its role in an increasing number of conditions is being reported in parallel with the advances of the technology. Currently, as a clinical tool, OCT is particularly useful for the structural measurement of peripapillary retinal nerve fiber layer thickness, optic nerve head volumetric analysis, and macular anatomy...
October 2015: Seminars in Neurology
https://www.readbyqxmd.com/read/26148443/sd-oct-to-distinguish-papilledema-from-pseudopapilledema
#11
V M Asensio-Sánchez, L Trujillo-Guzmán
CASES REPORT: Two patients presented with headache and bilateral papillary edema. Patient 1 was found to have a papilledema (P) with intracranial pressure of 32cmH2O. Patient 2 was found to have a migraine with a pseudopapilledema (PP) (optic nerve head drusen). SD-OCT was used to image the optic disc, subretinal hyporeflective space (SHS), and alpha-angle (Aα). DISCUSSION: Optic disc SD-OCT may be useful for differentiating disc morphology in P and PP. The area of the SHS and the Aα were higher in the P patient than in the patient with PP...
October 2015: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/25939987/clinical-and-multimodal-imaging-characteristics-of-acute-vogt-koyanagi-harada-disease-unassociated-with-clinically-evident-exudative-retinal-detachment
#12
Sonia Attia, Sana Khochtali, Rim Kahloun, Dhiaeddine Ammous, Bechir Jelliti, Salim Ben Yahia, Sonia Zaouali, Moncef Khairallah
The purpose of this study was to describe the clinical and multimodal imaging findings in acute Vogt-Koyanagi-Harada (VKH) disease without clinically evident exudative retinal detachment (ERD). We retrospectively reviewed the charts of 18 patients (36 eyes), diagnosed with acute VKH disease without clinically evident ERD. All patients underwent complete ophthalmic examination, fundus photography, optical coherence tomography (OCT), B-scan ultrasonography, fluorescein angiography (FA), and indocyanine green angiography (ICGA)...
February 2016: International Ophthalmology
https://www.readbyqxmd.com/read/25884956/binarization-of-enhanced-depth-imaging-optical-coherence-tomographic-images-of-an-eye-with-wyburn-mason-syndrome-a-case-report
#13
Akiko Iwata, Yoshinori Mitamura, Masanori Niki, Kentaro Semba, Mariko Egawa, Takashi Katome, Shozo Sonoda, Taiji Sakamoto
BACKGROUND: To report a thicker choroid and larger choroidal luminal area in an eye with Wyburn-Mason syndrome. To the best of our knowledge, this is the first report demonstrating an increase in the choroidal thickness and the luminal area in a case of Wyburn-Mason syndrome. In addition, we report the changing appearance of retinal arteriovenous malformations over a 16-year period. CASE PRESENTATION: A 27-year-old woman, who was diagnosed with Wyburn-Mason syndrome at age 11 years, visited our clinic...
2015: BMC Ophthalmology
https://www.readbyqxmd.com/read/25784265/binarization-of-enhanced-depth-imaging-optical-coherence-tomographic-images-of-an-eye-with-wyburn-mason-syndrome-a-case-report
#14
Akiko Iwata, Yoshinori Mitamura, Masanori Niki, Kentaro Semba, Mariko Egawa, Takashi Katome, Shozo Sonoda, Taiji Sakamoto
BACKGROUND: To report a thicker choroid and larger choroidal luminal area in an eye with Wyburn-Mason syndrome. To the best of our knowledge, this is the first report demonstrating an increase in the choroidal thickness and the luminal area in a case of Wyburn-Mason syndrome. In addition, we report the changing appearance of retinal arteriovenous malformations over a 16-year period. CASE PRESENTATION: A 27-year-old woman, who was diagnosed with Wyburn-Mason syndrome at age 11 years, visited our clinic...
December 2015: BMC Ophthalmology
https://www.readbyqxmd.com/read/25709280/tremendous-result-of-bevacizumab-in-malignant-hypertensive-retinopathy
#15
Ali M Al-Halafi
Signs of hypertensive retinopathy are common and are correlated with elevated blood pressure. Patients who have swelling of both optic discs and very high blood pressure (i.e., malignant retinopathy) need urgent antihypertensive treatment. A patient was reported with malignant hypertensive retinopathy who recovered promptly following single intravitreal bevacizumab injection. Intravitreal bevacizumab (1.25 mg/0.05 mL) was injected in two eyes of a patient having malignant hypertensive retinopathy with optic disc edema, macular edema, and retinal exudates...
January 2015: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/25690978/spectral-domain-optical-coherence-tomography-imaging-of-mucopolysaccharidoses-i-ii-and-vi-a
#16
Susie Seok, In Jeong Lyu, Kyung Ah Park, Sei Yeul Oh
PURPOSE: The purpose of this study was to describe the spectral domain optical coherence tomography (SD-OCT) characteristics of patients with retinal manifestations of mucopolysaccharidoses (MPSs) I, II, and IV A. DESIGN: The research was a prospective, observational study. METHODS: Fourteen consecutive patients with variants of MPS and 15 healthy subjects underwent ophthalmic assessments including fundus examinations and SD-OCT. RESULTS: The fundus examinations revealed that four patients (two MPS I and two MPS II) had pigmented retinopathy in both eyes...
December 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/25632360/purtscher-like-retinopathy
#17
Rita Massa, Carolina Vale, Mafalda Macedo, Maria João Furtado, Miguel Gomes, Miguel Lume, Angelina Meireles
Purtscher-like retinopathy is associated with retinal hemorrhages and ischaemia probably due to the complement-mediated leukoembolization. It is a rare and severe angiopathy found in conditions such as acute pancreatitis. Case. We present a case of a 53-year-old man who presented with a Purtscher-like retinopathy associated with the development of acute pancreatitis in the context of a Klatskin tumour (a hilar cholangiocarcinoma). The ophthalmologic evaluation revealed the best corrected visual acuity (BCVA) of 20/32 in the right eye (RE) and of 20/40 in the left eye (LE); biomicroscopy of anterior segment showed scleral icterus and fundoscopy revealed peripapillary cotton-wool spots, optic disc edema, and RPE hypo- and hyperpigmentation in the middle peripheral retina in both eyes with an intraretinal hemorrhage in the LE...
2015: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/25443199/-debut-of-leber-s-hereditary-optic-neuropathy-macular-segmentation-analysis-using-optical-coherence-tomography
#18
E Santos-Bueso, A Asorey-García, J Porta-Etessam, J M Vinuesa-Silva, J García-Sánchez
CASE REPORT: Two clinical cases are presented of two family relatives newly diagnosed with Leber hereditary optic neuropathy (LHON) and G11778A mutation analysis by optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, California, USA) layer peripapillary fibers retina (RNFL) and ganglion cell and internal plexiform layers (GCL/IPL) using macular segmentation. DISCUSSION: The analysis of the macula by OCT segmentation (version 6.0 Cirrus OCT) allows the GCL/IPL to be evaluated without the interindividual variability of peripapillary RNFL distribution or the presence of edema of the optic disc...
May 2015: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/25257770/subretinal-fluid-is-common-in-experimental-non-arteritic-anterior-ischemic-optic-neuropathy
#19
C Yu, J K Ho, Y J Liao
PURPOSE: Anterior ischemic optic neuropathy (AION) is an important cause of acute vision loss for which several animal models exist. It has been associated with subretinal fluid in a previous study on patients but not yet so in animal models. PATIENTS AND METHODS: A patient presented with acute non-arteritic AION (NAION) and underwent ophthalmic evaluation and testing including fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT). On the basis of the patient's findings, we used SD-OCT circular and volume scans to analyze retinal changes in a murine model of NAION...
December 2014: Eye
https://www.readbyqxmd.com/read/25245897/ocular-outcomes-evaluation-in-a-14-day-head-down-bed-rest-study
#20
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
INTRODUCTION: We evaluated ocular outcomes in a 14-d head-down tilt (HDT) bed rest (BR) study designed to simulate the effects of microgravity on the human body. METHODS: Healthy subjects were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented (e.g., strict sleep-wake cycle, standardized diet, 24-hour-a-day BR, continuous video monitoring). Subjects maintained a 6° HDT position for 14 consecutive days. Weekly ophthalmological examinations were performed in the sitting (pre/post-BR) and HDT (in-bed phase) positions...
October 2014: Aviation, Space, and Environmental Medicine
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