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https://www.readbyqxmd.com/read/28641680/ophthalmological-evaluation-of-integrated-resistance-and-aerobic-training-during-70-day-bed-rest
#1
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
INTRODUCTION: We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR). METHODS: Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28611153/effects-of-short-term-mild-hypercapnia-during-head-down-tilt-on-intracranial-pressure-and-ocular-structures-in-healthy-human-subjects
#2
Steven S Laurie, Gianmarco Vizzeri, Giovanni Taibbi, Connor R Ferguson, Xiao Hu, Stuart M C Lee, Robert Ploutz-Snyder, Scott M Smith, Sara R Zwart, Michael B Stenger
Many astronauts experience ocular structural and functional changes during long-duration spaceflight, including choroidal folds, optic disc edema, globe flattening, optic nerve sheath diameter (ONSD) distension, retinal nerve fiber layer thickening, and decreased visual acuity. The leading hypothesis suggests that weightlessness-induced cephalad fluid shifts increase intracranial pressure (ICP), which contributes to the ocular structural changes, but elevated ambient CO2 levels on the International Space Station may also be a factor...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28492874/peripapillary-retinal-pigment-epithelium-layer-shape-changes-from-acetazolamide-treatment-in-the-idiopathic-intracranial-hypertension-treatment-trial
#3
Jui-Kai Wang, Randy H Kardon, Johannes Ledolter, Patrick A Sibony, Mark J Kupersmith, Mona K Garvin
Purpose: Recent studies indicate that the amount of deformation of the peripapillary retinal pigment epithelium and Bruch's membrane (pRPE/BM) toward or away from the vitreous may reflect acute changes in cerebrospinal fluid pressure. The study purpose is to determine if changes in optic-nerve-head (ONH) shape reflect a treatment effect (acetazolamide/placebo + weight management) using the optical coherence tomography (OCT) substudy of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) at baseline, 3, and 6 months...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28405756/-maculopathy-with-optic-nerve-pits-morphological-criteria-in-sd%C3%AF-%C3%AF-oct
#4
K Wehrmann, S Stumpfe, M Pettenkofer, N Feucht, C Lohmann, M Maier
PURPOSE: Optic pit is a congenital anomaly with malformation similar to coloboma of the optic disc. The cause of optic pit maculopathy is controversial. We used high resolution OCT to investigate changes in the vitreoretinal and vitreopapillary transition within optic pit eyes. METHODS: The vitreoretinal and vitreo-papillary transition of 12 eyes was accurately analyzed using SD-OCT. We registered the following criteria: liquefaction of prepapillary vitreous, papillary vitreous traction, discontinuity within the hyaloid cortex and communication spaces between pit and retinal edema...
April 12, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28336281/-optic-disc-changes-by-optical-coherence-tomography-in-optic-disc-edema-in-lom%C3%A3
#5
M A K Santos, K Vonor, D K Ayena, K R Kuaovi, K P Balo
OBJECTIVE: To study the influence of optic disc edema (ODE) on the dimensions of the disc and the thickness of the retinal nerve fiber layer (RNFL) by optical coherence tomography (OCT) in Lomé. PATIENTS AND METHODS: This was a retrospective study which took place in a general ophthalmology office in the city. Twenty-six eyes were examined for ODE (cases) between January 2013 and May 2015, and 26 healthy eyes (control group) were considered in this study. The control group was recruited taking age into account with a variation not exceeding 5 years compared to the ODE cases...
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28196198/en-face-doppler-optical-coherence-tomography-measurement-of-total-retinal-blood-flow-in-diabetic-retinopathy-and-diabetic-macular-edema
#6
COMPARATIVE STUDY
ByungKun Lee, Eduardo A Novais, Nadia K Waheed, Mehreen Adhi, Talisa E de Carlo, Emily D Cole, Eric M Moult, WooJhon Choi, Mark Lane, Caroline R Baumal, Jay S Duker, James G Fujimoto
Importance: Alterations in ocular blood flow play an important role in the pathogenesis and progression of diabetic retinopathy (DR). However, the measurement of retinal blood flow in clinical studies has been challenging. En face Doppler optical coherence tomography (OCT) provides an effective method for measuring total retinal blood flow (TRBF) in the clinic. Objective: To investigate TRBF in eyes with DR of varying severity, with or without diabetic macular edema (DME), using en face Doppler OCT...
March 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28058166/imaging-methods-in-the-diagnosis-of-optic-disc-drusen
#7
REVIEW
Betül Tuğcu, Hakan Özdemir
Optic disc drusen (ODD) are benign congenital anomalies of the optic nerve characterized by calcified hyaline bodies. While superficial drusen can be diagnosed easily during fundus examination, detecting buried drusen requires the use of additional imaging methods such as B-scan ultrasonography (USG), fundus fluorescein angiography (FFA), computed tomography (CT) and fundus autofluorescence (FAF). ODD can be detected by USG with the presentation of highly reflective round structures. ODD appear as hyperautofluorescent areas on FAF and bright spots on CT scans...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27241814/vogt-koyanagi-harada-disease
#8
REVIEW
Ghazala A Datoo O'Keefe, Narsing A Rao
Vogt-Koyanagi-Harada disease, a severe bilateral granulomatous intraocular inflammation associated with serous retinal detachments, disk edema, and vitritis, with eventual development of a sunset glow fundus, is an autoimmune inflammatory condition mediated by T cells that target melanocytes in individuals susceptible to the disease. Vogt-Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, uveitic, convalescent, and recurrent, with extraocular manifestations including headache, meningismus, hearing loss, poliosis, and vitiligo, to varying degrees...
January 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27157148/retinal-astrocytic-hamartoma-arises-in-nerve-fiber-layer-and-shows-moth-eaten-optically-empty-spaces-on-optical-coherence-tomography
#9
Carol L Shields, Emil A T Say, Timothy Fuller, Saurabh Arora, Wasim A Samara, Jerry A Shields
PURPOSE: To evaluate the specific spectral-domain (SD) optical coherence tomography (OCT) features of retinal astrocytic hamartoma (RAH) and the relationship of these features with tumor size and location. DESIGN: Retrospective case series. PARTICIPANTS: Forty-seven eyes of 42 patients with RAH. METHODS: All patients with clinically confirmed RAH were imaged with fundus photography and SD OCT. MAIN OUTCOME MEASURES: Precise OCT location of RAH features and the relationship of patient age, visual acuity, tumor size, and tumor location to the presence and size of intralesional optically empty spaces (OESs), appearing as so-called moth-eaten spaces...
August 2016: Ophthalmology
https://www.readbyqxmd.com/read/27041286/-optic-disc-drusen-and-their-complications
#10
H Štrofová, A Jarošová
UNLABELLED: The aim of the study was to analyze the group of patients with optic disc drusen focusing on possible complications of this disease. MATERIAL AND METHODS: In our group of patients, we examined 46 eyes of 23 patients with the suspicion of optic disc drusen during the period from May 2013 until January 2014. In all adult patients, we examined the anterior and posterior segment of the eye biomicroscopically, established the visual acuity, measured the intraocular pressure, examined the visual field, performed the ultrasound examination of the eye (A and B-scan), analyzed the retinal nerve fiber layer (RNFL) by means of optic coherence tomography (OCT), and color and red-free photography...
February 2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/27023703/new-findings-in-diabetic-maculopathy-and-proliferative-disease-by-swept-source-optical-coherence-tomography-angiography
#11
REVIEW
Paulo E Stanga, Alessandro Papayannis, Emmanouil Tsamis, Francesco Stringa, Tim Cole, Yvonne D'Souza, Assad Jalil
PURPOSE: To describe the optical coherence tomography (OCT) angiography (OCTA) features of diabetic retinopathy. METHODS: Retrospective serial case reports were examined of patients who underwent routine clinical examination and OCTA with both DRI OCT Atlantis prototype and Triton Swept-Source OCT of the posterior pole and mid-periphery. When considered necessary, fluorescein fundus angiography (FFA) with OPTOS California wide-field imaging was performed. The findings were compared with the current literature...
2016: Developments in Ophthalmology
https://www.readbyqxmd.com/read/26953028/advances-in-retinal-imaging-for-diabetic-retinopathy-and-diabetic-macular-edema
#12
Colin Siang Hui Tan, Milton Cher Yong Chew, Louis Wei Yi Lim, Srinivas R Sadda
Diabetic retinopathy and diabetic macular edema (DME) are leading causes of blindness throughout the world, and cause significant visual morbidity. Ocular imaging has played a significant role in the management of diabetic eye disease, and the advent of advanced imaging modalities will be of great value as our understanding of diabetic eye diseases increase, and the management options become increasingly varied and complex. Color fundus photography has established roles in screening for diabetic eye disease, early detection of progression, and monitoring of treatment response...
January 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/26868753/ocular-outcomes-comparison-between-14-and-70-day-head-down-tilt-bed-rest
#13
COMPARATIVE STUDY
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
PURPOSE: To compare ocular outcomes in healthy subjects undergoing 14- and/or 70-day head-down-tilt (HDT) bed rest (BR). METHODS: Participants were selected by using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects maintained a 6° HDT position for 14 and/or 70 consecutive days. Weekly ophthalmologic examinations were performed in the sitting (pre/post-BR only) and HDT positions. Mixed-effects linear models compared pre- and post-HDT BR observations between 14- and 70-day HDT BR in best-corrected visual acuity, spherical equivalent, intraocular pressure (IOP), Spectralis OCT retinal nerve fiber layer thickness, peripapillary and macular retinal thicknesses...
February 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26580572/change-of-retinal-nerve-layer-thickness-in-non-arteritic-anterior-ischemic-optic-neuropathy-revealed-by-fourier-domain-optical-coherence-tomography
#14
Mei Han, Chen Zhao, Quan-Hong Han, Shiyong Xie, Yan Li
PURPOSE: To examine the changes of non-arteritic anterior ischemic optic neuropathy (NAION) by serial morphometry using Fourier domain optical coherence tomography (FD-OCT). MATERIALS AND METHODS: Retrospective study in patients with newly diagnosed NAION (n=33, all unilateral) and controls (n=75 unilateral NAION patients with full contralateral eye vision) who underwent FD-OCT of the optic disk, optic nerve head (ONH), and macula within 1 week of onset and again 1, 3, 6, and 12 months later...
August 2016: Current Eye Research
https://www.readbyqxmd.com/read/26535468/optic-nerve-sheath-melanoma-presenting-as-a-central-retinal-vein-occlusion
#15
Alexander Barash, Patrick A Sibony, Nigel A Stippa, Nariman S Boyle, James E Davis
A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma...
March 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/26526593/linezolid-induced-retinopathy
#16
Dae Hyun Park, Tae Kwann Park, Young-Hoon Ohn, Jong Sook Park, Jee Ho Chang
PURPOSE: While optic neuropathy is a well-known cause of visual disturbances in linezolid-treated patients, the possibility of linezolid-related retinopathy has not been investigated. Here, we report a case of retinopathy demonstrated by multifocal electroretinogram (mfERG) in a linezolid-treated patient. METHOD AND RESULTS: A 61-year-old man with extensively drug-resistant pulmonary tuberculosis treated with linezolid for 5 months presented with painless loss of vision in both eyes...
December 2015: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/26444402/optical-coherence-tomography-for-the-neurologist
#17
REVIEW
Rachel C Nolan, Kannan Narayana, Steven L Galetta, Laura J Balcer
Optical coherence tomography (OCT) is a relatively new technology that is now routinely and very widely used by ophthalmologists for structural documentation of the optic nerve and retina. In neuro-ophthalmology and neurology, the value of OCT is ever expanding; its role in an increasing number of conditions is being reported in parallel with the advances of the technology. Currently, as a clinical tool, OCT is particularly useful for the structural measurement of peripapillary retinal nerve fiber layer thickness, optic nerve head volumetric analysis, and macular anatomy...
October 2015: Seminars in Neurology
https://www.readbyqxmd.com/read/26148443/sd-oct-to-distinguish-papilledema-from-pseudopapilledema
#18
V M Asensio-Sánchez, L Trujillo-Guzmán
CASES REPORT: Two patients presented with headache and bilateral papillary edema. Patient 1 was found to have a papilledema (P) with intracranial pressure of 32cmH2O. Patient 2 was found to have a migraine with a pseudopapilledema (PP) (optic nerve head drusen). SD-OCT was used to image the optic disc, subretinal hyporeflective space (SHS), and alpha-angle (Aα). DISCUSSION: Optic disc SD-OCT may be useful for differentiating disc morphology in P and PP. The area of the SHS and the Aα were higher in the P patient than in the patient with PP...
October 2015: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/25939987/clinical-and-multimodal-imaging-characteristics-of-acute-vogt-koyanagi-harada-disease-unassociated-with-clinically-evident-exudative-retinal-detachment
#19
Sonia Attia, Sana Khochtali, Rim Kahloun, Dhiaeddine Ammous, Bechir Jelliti, Salim Ben Yahia, Sonia Zaouali, Moncef Khairallah
The purpose of this study was to describe the clinical and multimodal imaging findings in acute Vogt-Koyanagi-Harada (VKH) disease without clinically evident exudative retinal detachment (ERD). We retrospectively reviewed the charts of 18 patients (36 eyes), diagnosed with acute VKH disease without clinically evident ERD. All patients underwent complete ophthalmic examination, fundus photography, optical coherence tomography (OCT), B-scan ultrasonography, fluorescein angiography (FA), and indocyanine green angiography (ICGA)...
February 2016: International Ophthalmology
https://www.readbyqxmd.com/read/25884956/binarization-of-enhanced-depth-imaging-optical-coherence-tomographic-images-of-an-eye-with-wyburn-mason-syndrome-a-case-report
#20
Akiko Iwata, Yoshinori Mitamura, Masanori Niki, Kentaro Semba, Mariko Egawa, Takashi Katome, Shozo Sonoda, Taiji Sakamoto
BACKGROUND: To report a thicker choroid and larger choroidal luminal area in an eye with Wyburn-Mason syndrome. To the best of our knowledge, this is the first report demonstrating an increase in the choroidal thickness and the luminal area in a case of Wyburn-Mason syndrome. In addition, we report the changing appearance of retinal arteriovenous malformations over a 16-year period. CASE PRESENTATION: A 27-year-old woman, who was diagnosed with Wyburn-Mason syndrome at age 11 years, visited our clinic...
2015: BMC Ophthalmology
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