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habitual abortion

Roy Kessous, Ilana Shoham-Vardi, Gali Parientel, Eyal Sheiner
In recent years there is a significant increase in the rate of the metabolic syndrome. Correspondingly, and possibly due to this increase, there is a significant increase in cardiovascular events in women. Contradictory to the concept that obstetric complication is limited to pregnancy, some obstetric complications may cause or seemingly provide a preliminary sign for future maternal morbidity. In recent years there have been an increasing number of studies that examined the theory that vascular-related complications of pregnancy may be associated with increased risk for future maternal cardiovascular morbidity...
May 2016: Harefuah
S G Cheshik, L B Kisteneva
The goal of this work was the evaluation of the frequency of human CMV infection among the women, whose pregnancy ended in miscarriage, detection of active forms of infection and treatment before pregnancy. Virological and sero-immunological techniques were used. A total of 116 women who had miscarriages before the 28 week of pregnancy were submitted to the CMV test. 109 women (94.0%) demonstrated positive results. 49 women (42.2%) had active form of the cytomegalovirus infection. 13 women (26.5%) had the recurrent form and 36 patients (73...
2016: Voprosy Virusologii
Philipp Scholz, Markus Auler, Bent Brachvogel, Thomas Benzing, Peter Mallman, Thomas Streichert, Andreas R Klatt
Anti-phospholipid syndrome (APS) is one of the main causes for recurrent miscarriages. The diagnosis of APS is based on the occurrence of clinical symptoms such as thrombotic events or obstetric complications as well as the detection of antiphospholipid antibodies directed against β2-glycoprotein I and cardiolipin, or a positive lupus anticoagulant assay. However, there is a subpopulation of patients with clinical symptoms of APS, but the lack of serological markers (seronegative APS). In addition, a large proportion of patients with unexplained recurrent miscarriages exist...
2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
X P Li, L N Song, L P Tian, Y S Zhang
Habitual abortion is associated with the altered expression of multiple genes. This study was carried out to investigate the relationship between expression of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein 2 (MCP2 or CCL8) and habitual abortion. This was done by detecting and comparing their relative expression in peripheral blood and placental villi of patients and healthy fertile women. Based on our previous research, 85 subjects with habitual abortion (study group) and 40 healthy fertile women (control group), who were admitted to our hospital between June 2013 and December 2014, were enrolled in this study...
2016: Genetics and Molecular Research: GMR
Ramandeep Kaur, Kapil Gupta
Miscarriage is the spontaneous loss of a fetus before it is viable, occurring at a rate of 15-20%. Recurrent spontaneous abortion (RSA) or habitual miscarriage is defined as repeated occurrence of 3 or more miscarriages before 20(th) week of gestation accounting for the most common complication of early pregnancy in humans. Various etiological factors responsible for recurrent miscarriage are anatomical, genetical, endocrinological, immunological, and infectious. The endocrinological abnormalities may be polycystic ovarian syndrome, hyperprolactinemia, luteal phase defect, thyroid dysfunction, diabetes, or hyperandrogenism contributing to recurrent pregnancy loss...
April 2016: International Journal of Applied and Basic Medical Research
P Ivanov, Tsv Lukanov, E Konova, Sv Blajeva, V Rilcheva, T Tsvyatkovska, K Kovacheva
The increased number of peripheral blood NK (pNK) cells has been discussed as a factor for embryo implantation failure and early pregnancy loss. However, the assessment of activated pNK cells with increased cytotoxic activity could be a distinct marker for immune dysregulation leading to pregnancy complications. CD69 membrane receptor expression has been measured by flow cytometry in different subtypes of pNK cells in 55 women with two or more pregnancy loss between six and twelve week of gestation with absence of any hormonal, anatomical or inherited cause for pregnancy loss and in 43 healthy women with at least one delivery at term and no history for reproductive failure...
2015: Akusherstvo i Ginekologii︠a︡
E N Tolmacheva, S A Vasilyev, E A Sazhenova, D I Zhigalina, E I Grigorovich, T V Nikitina, A A Melnikov, E S Zhabina, T V Ivanova, I D Evtushenko, I N Lebedev
Sex ratio in first trimester of pregnancy is skewed due to preferential elimination of female embryos. It could be resulted from aberrant X-chromosome inactivation. X-chromosome inactivation was analyzed in extraembryonic tissues of miscarriages and induced abortions with 46, XX karyotype. In chorion cytotrophoblast of both miscarriages and induced abortions observed either random or skewed X-chromosome inactivation. In extraembryonic mesoderm of the control group, random inactivation was observed, whereas 15% of miscarriages had skewed X-chromosome inactivation...
2015: Tsitologiia
Koji Habe, Hideo Wada, Takeshi Matsumoto, Kohshi Ohishi, Makoto Ikejiri, Kimiko Matsubara, Tatsuhiko Morioka, Yuki Kamimoto, Tomoaki Ikeda, Naoyuki Katayama, Hitoshi Mizutani
OBJECTIVE: Antiphospholipid syndrome (APS) is a well-known complication of habitual abortion and/or thrombosis and is frequently associated with autoimmune diseases. METHODS: We retrospectively investigated the relationships between the presence of antiphospholipid antibodies (aPLs) and the incidence of thrombotic events (THEs) in 147 patients with various connective tissue diseases (CTD) suspected of having APS and 86 patients with idiopathic thrombocytopenic purpura (ITP)...
2016: Internal Medicine
K Huml, L Kantor, M Procházka, M Studničková, R Pilka
OBJECTIVE: The use of laparoscopic abdominal cerclage in a patient with habitual miscarriage. DESIGN: Case report and literature review. SETTING: Department of Obstetrics and Gynecology, University Hospital Olomouc, Faculty of Medicine, Palacký University Olomouc, Department of Neonatology, University Hospital Olomouc, Faculty of Medicine, Palacký University Olomouc, Institute of Medical Genetics, University Hospital Olomouc, Faculty of Medicine, Palacký University Olomouc...
January 2016: Ceská Gynekologie
S van Heukelum, J Kelderhuis, P Janssen, G van Luijtelaar, A Lüttjohann
INTRODUCTION: Seizure control is one of the ultimate aims of epileptology: here acute and prolonged effects of closed loop high-frequency stimulation of the somatosensory cortex on the expression of spontaneously occurring spike-wave discharges (SWD) were investigated in a genetic absence model. Effects of closed loop stimulation in the experimental group were compared with a yoked control group allowing to investigate the effect of timing related to SWD occurrence, while controlling for amount and intensity of stimulation...
June 2, 2016: Neuroscience
Ayla Eser, Ilknur Inegol Gumus, Husamettin Erdamar, Ikbal Kaygusuz, Melahat Yildirim, Betul Usluogullari, Muzeyyen Duran Erdolu, Serap Aynur Simavli, Ramazan Yigitoglu, Nilgun Ozturk Turhan
OBJECTIVE: The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable fibrinolysis inhibitor (carboxypeptidase B2) between women with a history of recurrent miscarriage and those with no recurrent miscarriage history. MATERIALS AND METHODS: A case-controlled, prospective study design was adopted to compare women with a history of two or more first-trimester miscarriages (n = 42) with those with no history of recurrent miscarriage (n = 36)...
February 2016: Taiwanese Journal of Obstetrics & Gynecology
Khulood Murad
BACKGROUND: Uterine fibroids (UFs) may impair fertility and promote miscarriage. The optimal treatment for women with UFs who wish to conceive is uncertain. CASE: A 35-year-old woman of African ancestry with a history of recurrent miscarriage (gravida 5, para 0) had a solitary submucosal UF (volume: 102.4 cm(3)) extending into the uterine cavity. Following a three-month course of ulipristal acetate (UPA) 5 mg daily, UF volume decreased to 72.1 cm(3). The patient conceived approximately two months after discontinuing UPA...
January 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Lisha Tang, Chao Gao, Li Gao, Yugui Cui, Jiahao Sha, Jiayin Liu
OBJECTIVE: To investigate the expression of miRNA-4497 in human chorionic villi from early recurrent miscarriage and the influence on apoptosis. METHODS: The expression of miRNA-4497 in chorionic villi tissues collected from 20 early recurrent miscarriage cases and 20 controls were analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). Human BeWo trophoblastic strains transfected with miRNA-4497 mimic were collected before transfection and 24 h later to measure apoptosis by flow cytometry...
December 8, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
S Yu Yuriev, I S Popova, L R Mustafina, I A Zakonova, A E Sazonov, A B Poletaev
The study was carried out to evaluate clinical informativeness ofstudies of immunological parameters of structural and functional elements of endometrium in complex with profile of embritropic autoimmune antibodies under non-carrying of pregnancy The sampling consisted of 19 women of reproductive age with episodes of non-carrying in first semester. They were examined for inherited thrombophilia and profiles of immune reactivity of natural regulatory auto-antibodies (ELI-P-Complex). The biopsy material of endometrium was subjected to histological and immune histochemical (CD16, CD56, CD68, CB138, estrogen and progesterone receptors) analyses...
October 2015: Klinicheskaia Laboratornaia Diagnostika
S Saboori, Z Noormohammadi, S Zare-Karizi
BACKGROUND: Vascular endothelial growth factor (VEGF) plays a main role in fetal and placental angiogenesis and is secreted by different cells of endometrium and placenta. OBJECTIVE: In the present study we investigated the association of VEGF gene polymorphisms with recurrent spontaneous abortion (RSA). METHODS: A case-control study of 100 women with at least two consecutive pregnancy losses before 20 weeks of gestational age and 100 fertile controls was performed to evaluate four VEGF gene polymorphisms including +936C/T (rs3025039), -154G>A (rs1570360), rs3025010 and +5092A/C (rs2146323)...
2016: Bratislavské Lekárske Listy
Natalia V Kovaleva, Philip D Cotter
BACKGROUND: Mosaicism for chromosomal structural rearrangements (Rea) is rare and the timing and mechanisms of mosaic Rea formation, maintenance, and clinical manifestation are poorly understood. To date, there are no published data on the cytogenetic profile of mosaic Reas. The question as to whether the proportion of abnormal cells in the carrier's cultured blood is clinically significant remains unanswered. A previous study showed a strong female preponderance among carriers of mosaicism for Rea with pericentromeric breaks, indicating female-specific instability in early embryos...
2016: Molecular Cytogenetics
Lu Li, Lixia Dou, Ping Chung Leung, Tony Kwok Hung Chung, Chi Chiu Wang
BACKGROUND: Recurrent miscarriage affects 1% to 3% of women of reproductive age and mostly occurs before the 10th week of gestation (and around the same gestational week in subsequent miscarriages). Although most pregnant women may not recognise a miscarriage until uterine bleeding and cramping occur, a repeat miscarriage after one or more pregnancy loss and the chance of having a successful pregnancy varies. To date, there is no universally accepted treatment for unexplained recurrent miscarriage...
2016: Cochrane Database of Systematic Reviews
J H Fu
PURPOSE: This study aims to determine the curative effect of cyclosporin A (CsA) in treating refractory immune recurrent spontaneous abortion (RSA). Patients with recurrent abortion caused by dysimmunity were enrolled. MATERIALS AND METHODS: The patients were given aspirin, prednisone, heparin, immunotherapy with their husband's leukomonocyte, and intravenous immunoglobulin (IVIG) treatment, but treatment outcomes were unsuccessful. Therefore, CsA was added to treat the women before and after pregnancy...
2015: Clinical and Experimental Obstetrics & Gynecology
Ying Wang, Xianghua Lin, Qiuju Wu, Mingpeng Zhao, Shiyao Xian, Dijin Lin, Longqiaozi Sun, Jian He, Yunwen Bao, Chaohui Duan
BACKGROUND: This study was to investigate the association between thrombophilia and REM by the change of thrombophilia markers and to evaluate their contribution in diagnosis and treatment of REM. METHODS: 199 women with REM history were divided into two groups within the study group: 151 pregnant (REM-P) and 48 nonpregnant (REM-NP). In addition, 121 healthy age-matched women without REM history were divided into two groups of the control group: 75 pregnant (Control-P) and 46 nonpregnant (Control-NP)...
2015: Clinical Laboratory
Yu Zhang, Jianmei Wang, Yan Gu, Yi Li
OBJECTIVE: To explore the relationship between the expression of chemokines and their receptors in the maternal-fetal interface and the pathogenesis of unexplained recurrent spontaneous abortion (URSA). METHODS: 8-10 weeks CBA/J female mice were mated with DBA/2 and BALB/c male mice at the ratio of 2:1 to establish the model of normal pregnant mice (CBA/J × BALB/c) and URSA mice (CBA/J × DBA/2). Sixty mice were divided into 6 groups, with ten in each group. The mice in the normal unpregnancy group were executed for endometrial tissues; the mice in the embryonic implantation normal pregnancy group were executed for endometrial tissues at the sixth day of gestation; the mice in the embryonic development normal pregnancy group were executed for decidua and chorionic tissues at the fourteenth day of gestation...
August 2015: Zhonghua Fu Chan Ke za Zhi
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