Xifeng Liu, Maria D Astudillo Potes, Vitalii Serdiuk, Babak Dashtdar, Areonna C Schreiber, Asghar Rezaei, A Lee Miller, Abdelrahman M Hamouda, Mahnoor Shafi, Benjamin D Elder, Lichun Lu
Spinal injuries or diseases necessitate effective fusion solutions, and common clinical approaches involve autografts, allografts, and various bone matrix products, each with limitations. To address these challenges, we developed an innovative moldable click chemistry polymer cement that can be shaped by hand and self-cross-linked in situ for spinal fusion. This self-cross-linking cement, enabled by the bioorthogonal click reaction, excludes the need for toxic initiators or external energy sources. The bioactivity of the cement was promoted by incorporating nanohydroxyapatite and microspheres loaded with recombinant human bone morphogenetic protein-2 and vascular endothelial growth factor, fostering vascular induction and osteointegration...
March 18, 2024: ACS Applied Bio Materials