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https://www.readbyqxmd.com/read/28735484/microsphere-based-assessment-of-dna-methylation-for-aml-prognosis
#1
Gerald B W Wertheim, Marlise R Luskin, Martin Carroll, Stephen R Master
Epigenetic dysregulation, including aberrant methylation of cytosine residues in DNA, is a hallmark of cancer and clearly results in oncogenic cellular alterations such as transcriptional attenuation of tumor suppressors and genomic instability. A number of studies have examined DNA methylation alterations in patients with acute myeloid leukemia (AML) and have shown that analysis of multilocus methylation patterns can identify biologically distinct AML subclasses and can predict patient prognosis. In order to utilize the prognostic capability of methylation analysis in a clinical setting, we have developed a microsphere-based HpaII tiny fragment enrichment by ligation-mediated PCR (xMELP) assay to interrogate the methylation state of genomic multiple loci along with a random forest-based classification algorithm that correlates DNA methylation status with patient prognosis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28734907/predicting-relapse-in-schizophrenia-is-bdnf-a-plausible-biological-marker
#2
Anilkumar Pillai, Nina R Schooler, Diya Peter, Stephen W Looney, Donald C Goff, Alexander Kopelowicz, John Lauriello, Theo Manschreck, Alan Mendelowitz, Del D Miller, Joanne B Severe, Daniel R Wilson, Donna Ames, Juan Bustillo, John M Kane, Peter F Buckley
Understanding the biological processes that underlie why patients relapse is an issue of fundamental importance to the detection and prevention of relapse in schizophrenia. Brain Derived Neurotrophic Factor (BDNF), a facilitator of brain plasticity, is reduced in patients with schizophrenia. In the present study, we examined whether decreases in plasma BDNF levels could be used as a biological predictor of relapse in schizophrenia. A total of 221 patients were prospectively evaluated for relapse over 30months in the Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared to Injectables: eValuating Efficacy (PROACTIVE) study...
July 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28734367/a-solid-contact-potassium-selective-electrode-with-moo2-microspheres-as-ion-to-electron-transducer
#3
Xianzhong Zeng, Wei Qin
A solid-contact ion-selective electrode (SC-ISE) for potassium with MoO2 microspheres as ion-to-electron transducer is described. MoO2 microsphers can be synthesized via the reduction of MoO3 nanobelts in an isopropanol solvent with a mild process, and the obtained MoO2 microspheres have been characterized by X-ray diffraction and field-emission scanning electron microscopy. With the application of MoO2 microspheres, the newly fabricated SC-ISE for K(+) exhibits a stable and rapid potential response. A near Nernstian slope of 55 mV/decade to potassium activities in the range of 10(-5) ‒ 10(-3) M is found and the detection limit is 10(-5...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28731205/smart-construction-of-nitrogen-doped-carbon-coated-mose2-microspheres-with-enhanced-performance-for-lithium-storage
#4
Wangjia Tang, Dong Xie, Tong Shen, Xiuli Wang, Donghuang Wang, Xuqing Zhang, Xinhui Xia, Jianbo Wu, Jiangping Tu
Exploring advanced anode materials with highly reversible capacity have gained great interests for large-scale lithium storage. Herein, a facile two-step method is developed to synthesize nitrogen-doped carbon coated MoSe2 microspheres via hydrothermal plus thermal polymerization. The MoSe2 microspheres composed of interconnected nanoflakes are homogeneously coated by thin nitrogen-doped carbon (N-C) layer. As an anode for lithium ion batteries, the MoSe2/N-C composite shows better reversibility, smaller polarization and higher electrochemical reactivity as compared to the unmodified MoSe2 microspheres...
July 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28730477/utilizing-the-luminex-magnetic-bead-based-suspension-array-for-rapid-multiplexed-phosphoprotein-quantification
#5
Adam Stewart, Udai Banerji
The study of protein phosphorylation is critical for the advancement of our understanding of cellular responses to external and internal stimuli. Phosphorylation, the addition of phosphate groups, most often occurs on serine, threonine, or tyrosine residues due to the action of protein kinases. This structural change causes the protein to become activated (or deactivated) and enables it in turn to initiate the phosphorylation of other proteins in a cascade, eventually causing cell-wide changes such as apoptosis, cell differentiation, and growth (among others)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730360/characterization-of-extracellular-polymeric-substance-eps-fractions-produced-by-microcystis-aeruginosa-under-the-stress-of-linoleic-acid-sustained-release-microspheres
#6
Lixiao Ni, Danye Li, Shiyi Rong, Lili Su, Wei Zhou, Peifang Wang, Chao Wang, Shiyin Li, Kumud Acharya
This paper focuses on the characterization of extracellular polymeric substances (EPS), which are composed of soluble EPS (SL-EPS), loosely bound EPS (LB-EPS), and tightly bound EPS (TB-EPS) produced by Microcystis aeruginosa under the stress of linoleic acid (LA) and LA sustained-release microspheres. Three-dimensional excitation-emission matrix (3D-EEM) fluorescence spectroscopy and Fourier transform infrared (FTIR) spectrometry were used to characterize three forms of EPS while the content of polysaccharide and protein was tested, respectively...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28730104/down-regulation-of-protein-kinase-c-alpha-ezrin-signals-in-light-induced-phagocytic-crisis-of-retinal-pigment-epithelium-cells
#7
Ya-Qiong Zhang, Yong-Gang Fan, Ya-Long Dang, Yan-Li Liu, Hua Liu, Li-Hua Li
AIM: To investigate the roles of PKC-α/ezrin signals in phagocytosis crisis of retinal pigment epithelium (RPE) cells in light damage model. METHODS: Light induced mice RPE injury model was established by continuously irradiating cool white light at different exposure time (0, 4, 8h light intensity: 4.18×10(-6) J/cm(2)). In vitro, human ARPE-19 cells treated with the doses and intensity (1.57×10(-6) J/cm(2)) of laser irradiation. Histology analysis was evaluated by hematoxylin and eosin (HE) staining...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28728935/transcatheter-arterial-chemoembolization-with-spherical-embolic-agent-in-patients-with-pulmonary-or-mediastinal-metastases-from-breast-cancer
#8
Norifumi Kennoki, Shinichi Hori, Takeo Yuki, Atsushi Hori
PURPOSE: To evaluate safety and feasibility of transcatheter arterial chemoembolization with superabsorbent polymer microspheres (SAP-MS) for patients with pulmonary or mediastinal metastasis from breast cancer. METHODS: Between November 2002 and January 2015, 14 patients with 29 unresectable pulmonary or mediastinal breast cancer metastases underwent transcatheter arterial chemoembolization using SAP-MS (50-100 μm) after injection of a combination of 2-4 types of anticancer drugs (eg, cisplatin [30 mg] + fluorouracil [500 mg], or epirubicin [40 mg] + mitomycin C [4 mg] + fluorouracil [500 mg])...
July 18, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28726424/self-encapsulating-poly-lactic-co-glycolic-acid-plga-microspheres-for-intranasal-vaccine-delivery
#9
Brittany A Bailey, Kashappa-Goud H Desai, Lukasz J Ochyl, Susan M Ciotti, James J Moon, Steven P Schwendeman
Herein we describe a formulation of self-encapsulating poly(lactic-co-glycolic acid) (PLGA) microspheres for vaccine delivery. Self-healing encapsulation is a novel encapsulation method developed by our group that enables the aqueous loading of large molecules into pre-made PLGA microspheres. Calcium phosphate (CaHPO4) adjuvant gel was incorporated into the microspheres as a protein-trapping agent for improved encapsulation of antigen. Microspheres were found to have a median size of 7.05 ± 0.31 µm, with a w/w loading of 0...
July 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28724984/ph-and-urea-estimation-in-urine-samples-using-single-fluorophore-and-ratiometric-fluorescent-biosensors
#10
Rashmi Chaudhari, Abhijeet Joshi, Rohit Srivastava
Kidney diseases remain often undiagnosed due to inefficient screening methods available at patient's disposal. Early diagnosis and effective management of kidney problems can best be addressed by the development of biosensors for commonly occurring clinical biomarkers. Here we report the development of single fluorophore and dual fluorophore ratiometric biosensors based on alginate microspheres for pH and urea analysis in urine samples. A facile method of air driven atomization was used for developing these polymeric fluorophore and enzyme based biosensors...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722425/self-focused-alscn-film-ultrasound-transducer-for-individual-cell-manipulation
#11
Benpeng Zhu, Chunlong Fei, Chen Wang, Yuhang Zhu, Xiaofei Yang, Hairong Zheng, Qifa Zhou, K Kirk Shung
Precise cell positioning is indispensable in the fields of biophysics and cellular biology. Acoustic microbeam produced by a highly focused ultrasound transducer has recently been investigated for a particle or cell manipulation. By virtue of the relatively good piezoelectric property, Sc doped AlN film was introduced for a highly focused ultrasound transducer application. Using a sputtering approach, a self-focused AlScN film based device has been designed, fabricated, and characterized at a frequency of ∼230 MHz...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722037/magnetite-hollow-microspheres-with-a-broad-absorption-bandwidth-of-11-9-ghz-toward-promising-lightweight-electromagnetic-microwave-absorption
#12
Ivan Shanenkov, Alexander Sivkov, Alexander Ivashutenko, Viktor Zhuravlev, Qing Guo, Liping Li, Guangshe Li, GuoDong Wei, Wei Han
High-performance magnetite-based hollow spheres with the advantages of low density and low loading content are promising as an ideal lightweight electromagnetic (EM) wave absorption candidate. However, the effective preparation methods for these hollow spheres are still limited, and as a result, materials design and practical applications based on their size-dependent EM microwave attenuation properties are poorly accessible. In this study, high quality magnetite hollow spheres were successfully prepared by a simple, fast, one-step, and scalable plasma dynamic method with sole use of inexpensive precursors (oxygen and mild steel)...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28720780/parameter-determination-and-transformation-for-the-focusing-of-dielectric-microspheres-illuminated-by-optical-needle
#13
Tongnan Xia, Hanming Guo, Jinbing Hu, Songlin Zhuang
By eliminating the spherical aberrations of microsphere we derived a simple but useful formula on the focusing of dielectric microsphere. On basis of this formula, not only can researchers determine the parameters of an optical microsphere system with super-resolution, but they can also perform parameter transformation. In order to facilitate the application, the principle of parameter transformation was summarized into three kinds of case listed in Table 1, which were all demonstrated numerically with concrete examples by finite-difference time-domain method...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28718920/microcapsules-biologically-prepared-using-perilla-frutescens-l-britt-essential-oil-and-their-use-for-extension-of-fruit-shelf-life
#14
Na Li, Zhi-Jun Zhang, Xiao-Jun Li, Hui-Zhen Li, Li-Xia Cui, Dong-Liang He
BACKGROUND: Perilla EO possess high antioxidant, antimicrobial and insecticidal activities, and have proven to be more reliable than chemically synthesized food preservatives. Nevertheless, EOs have disadvantages of facile photo-degradation and oxidation which limits their use in agriculture and food industries. Microencapsulation technology that generates a polymeric coating surrounding EOs could overcome these disadvantages. RESUILS: The EO concentration had a significant effect on encapsulation efficiency (EE) and loading capacity (LC)...
July 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28718226/in-situ-preparation-of-novel-layered-spinel-microsphere-reduced-graphene-oxide-heterostructured-cathode-for-ultrafast-charge-discharge-li-ion-batteries
#15
Dong Luo, Shaohua Fang, Li Yang, Shin-Ichi Hirano
Although Li-rich layered oxides (LLOs) have the highest capacity of any cathodes used at present, their current rate capability is far from meeting the requirements of electric vehicles and smart grids. Here, a novel layered-spinel-microsphere/rGO (LS@rGO) heterostructured cathode is prepared by in-situ technique. This cathode is composed of a spinel phase, two layered structures and a few of reduced graphene oxide (rGO, 1.08 wt% of carbon). It delivers a considerably competitive capacity (145 mA h g-1) at an ultrahigh charge-discharge rate of 60 C (12 A g-1)...
July 17, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28717974/improvement-of-oral-bioavailability-of-lopinavir-without-co-administration-of-ritonavir-using-microspheres-of-thiolated-xyloglucan
#16
Ashwini R Madgulkar, Mangesh R Bhalekar, Ashwini A Kadam
Lopinavir is a BCS Class IV drug exhibiting poor bioavailability due to P-gp efflux and limited permeation. The aim of this research was to formulate and characterize microspheres of lopinavir using thiolated xyloglucan (TH-MPs) as carrier to improve its oral bioavailability without co-administration of ritonavir. Thiomeric microspheres were prepared by ionotropic gelation between alginic acid and calcium ions. Interaction studies were performed using Fourier transform infrared spectroscopy (FT-IR). The thiomeric microspheres were characterized for its entrapment efficiency, T80, surface morphology, and mucoadhesion employing in vitro wash off test...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28717651/comparison-of-nonspherical-polyvinyl-alcohol-particles-and-microspheres-for-prostatic-arterial-embolization-in-patients-with-benign-prostatic-hyperplasia
#17
Jin Ho Hwang, Sang Woo Park, Il Soo Chang, Sung Il Jung, Hae Jeong Jeon, Yong Soo Lho, Hyeong Gon Kim, Sung Hyun Paick, Hyoung Keun Park
PURPOSE: To report early results following prostatic artery embolization (PAE) and compare outcomes between nonspherical polyvinyl alcohol (PVA) particles and microspheres to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). METHODS: PAE was performed in nine patients (mean age: 78.1 years) with symptomatic BPH. Embolization was performed using nonspherical PVA particles (250-355 μm) in four patients and microspheres (300-500 μm) in five patients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28714695/double-protected-all-inorganic-perovskite-nanocrystals-by-crystalline-matrix-and-silica-for-triple-modal-anti-counterfeiting-codes
#18
Leimeng Xu, Jiawei Chen, Jizhong Song, Jianhai Li, Jie Xue, Yuhui Dong, Bo Cai, Qingsong Shan, Boning Han, Haibo Zeng
Novel fluorescence with highly covert and reliable features is quite desirable to combat the sophisticated counterfeiters. Herein, we report a simultaneously triple-modal fluorescent characteristic of CsPbBr3@Cs4PbBr6/SiO2 by the excitation of thermal, ultraviolet (UV) and infrared (IR) light for the first time, which can be applied for the multiple modal anti-counterfeiting codes. The diphasic structure CsPbBr3@Cs4PbBr6 nanocrystals (NCs) were synthesized via the typical re-precipitation method followed by uniformly encapsulation into silica microspheres...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28714662/enhancing-the-osteogenic-capability-of-core-shell-bilayered-bioceramic-microspheres-with-adjustable-biodegradation
#19
Xiurong Ke, Chen Zhuang, Xianyan Yang, Jia Fu, Sanzhong Xu, Lijun Xie, Zhongru Gou, Juncheng Wang, Lei Zhang, Guojing Yang
This study describes the fabrication and biological evaluation of core-shell bilayered bioceramic microspheres with adjustable compositional distribution via a coaxial bilayer capillary system. Beyond the homogeneous hybrid composites, varying the diameter of capillary nozzles and the composition of the bioceramic slurries makes it easy to create bilayered β-tricalcium phosphate (CaP)/β-calcium silicate (CaSi) microspheres with controllable compositional distribution in the core or shell layer. Primary investigations in vitro revealed that biodegradation could be adjusted by compositional distribution or shell thickness and that poorly soluble CaP located on the shell layer of CaP or CaSi@CaP microspheres was particularly beneficial for mesenchymal stem cell adhesion and growth in the early stage, but the ion release from the CaP@CaSi exhibited a potent stimulating effect on alkaline phosphatase expression of the cells at longer times...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28712405/-changes-of-monocyte-and-monocyte-platelet-aggregates-in-different-subgroups-of-thrombotic-events-in-patients-with-acute-myocardial-infarction-during-pci
#20
Sheng Wang, Cuifang Sun, Wang Liao, Zhongwei Wu, Yudai Wang, Xiuxian Huang, Sijia Lu, Xiaoli Dong, Fujie Shuai, Bin Li
Objective To investigate the impact of thrombotic events on the alterations of monocyte and monocyte-platelet aggregates (MPAs) in patients with acute myocardial infarction (AMI) during percutaneous coronary intervention (PCI). Methods Blood was collected before PCI for flow cytometry. Monocyte subsets and MPAs were detected by four-color platform (CDl4-APC, CDl6-PE-Cy7, CD86-PE and CD41-Alexa Fluor(R)488). According to the expression of the platelet surface marker CD41, the number of monocyte subsets and MPAs was analyzed using the fluorescent microspheres of absolute counting tube...
July 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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