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https://www.readbyqxmd.com/read/29227278/an-automated-method-for-dynamic-red-blood-cell-aggregate-detection-in-microfluidic-flow
#1
Rym Mehri, Erfan Niazi, Catherine Mavriplis, Marianne Fenech
Red blood cell (RBC) aggregation is a unique phenomenon that occurs when red blood cells are subjected to low shear rates. Little is known about the sizes, shapes and behaviour of aggregates flowing in healthy humans. However, excessive aggregation has been shown to be an indication of pathological conditions. Therefore, characterizing RBC aggregates is important to medical research. The objective of this study was to develop a reliable technique based on image processing to assess and characterize human RBC aggregation subjected to controlled and measurable shear rates in a two-fluid flow microfluidic shearing system...
December 11, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29227109/fast-and-environmentally-friendly-microfluidic-technique-for-the-fabrication-of-polymer-microspheres
#2
Yanlin Zhang, Robert W Cattrall, Spas D Kolev
This paper reports on a novel microfluidic technique for the fabrication of microspheres of synthetic polymers including poly(vinyl chloride) (PVC), poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), poly(lactic acid) (PLA), and polystyrene (PS). The polymers are dissolved in tetrahydrofuran (THF) and the method is based on the diminished solubility of THF in a 20% (w/v) NaCl solution which allows the formation of droplets of the polymer solution. These polymer solution droplets are generated in a microfluidic system and their desolvation is accomplished within seconds by allowing the droplets to rise by buoyancy through a NaCl solution with a concentration lower than 15%...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29226920/coo-microspheres-and-metallic-co-evolved-from-hexagonal-%C3%AE-co-oh-2-plates-in-a-hydrothermal-process-for-lithium-storage-and-magnetic-applications
#3
KeYuan Ma, F Liu, Y F Yuan, X Q Liu, Jun Wang, J Xie, J P Cheng
CoO microspheres and metallic Co could be successfully synthesized by simply reacting cobalt acetate with a mixture solvent of ethylene glycol and deionized water in a hydrothermal process for different times. As the reaction proceeded, α-Co(OH)2, CoO and metallic Co were produced. To understand the phase evolution processes from α-Co(OH)2 to CoO and then metallic Co, a range of time-dependent experiments were carried out, and the intermediate products obtained at different reaction times were investigated in detail...
December 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29225235/solid-phase-extraction-of-trace-al-iii-fe-ii-co-ii-cu-ii-cd-ii-and-pb-ii-ions-in-beverages-on-functionalized-polymer-microspheres-prior-to-flame-atomic-absorption-spectrometric-determinations
#4
Hale Berber, Güzin Alpdogan
In this study, poly(glycidyl methacrylate-methyl methacrylate-divinylbenzene) was synthesized in the form of microspheres, and then functionalized by 2-aminobenzothiazole ligand. The sorption properties of these functionalized microspheres were investigated for separation, preconcentration and determination of Al(III), Fe(II), Co(II), Cu(II), Cd(II) and Pb(II) ions using flame atomic absorption spectrometry. The optimum pH values for quantitative sorption were 2 - 4, 5 - 8, 6 - 8, 4 - 6, 2 - 6 and 2 - 3 for Al(III), Fe(II), Co(II), Cu(II), Cd(II) and Pb(II), respectively, and also the highest sorption capacity of the functionalized microspheres was found to be for Cu(II) with the value of 1...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29225228/zinc-ion-immobilized-magnetic-microspheres-for-enrichment-and-identification-of-multi-phosphorylated-peptides-by-mass-spectrometry
#5
Se Won Bae, Jae Il Kim, Inseong Choi, Jiha Sung, Jong-In Hong, Woon-Seok Yeo
The selective isolation of phosphorylated peptides and subsequent analysis using mass spectrometry is important for understanding how protein kinase and phosphatase signals can precisely modulate the on/off states of signal transduction pathways. However, the isolation and detection of multi-phosphorylated peptides is still limited due to their distinct affinity to various materials and their poor ionization efficiency. Here, we report a highly efficient and selective enrichment of phosphorylated peptides using binuclear Zn2+-dipicolylamine complex-coated magnetic microspheres (ZnMMs)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29223387/tolerance-levels-of-plga-microspheres-in-the-eyes
#6
EDITORIAL
Kinam Park
No abstract text is available yet for this article.
November 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29222979/hierarchical-nico2o4-nanosheets-grown-on-hollow-carbon-microspheres-composites-for-advanced-lithium-ion-half-and-full-batteries
#7
Beibei Wang, Shaobo Cai, Gang Wang, Xiaojie Liu, Hui Wang, Jintao Bai
Hierarchical ultrathin NiCo2O4 nanosheeets grown on uniform hollow carbon microspheres (HC@NiCo2O4) are designed and fabricated by a solvothermal reaction followed with an annealing process. When evaluated as an anode for lithium ion batteries, the as-prepared HC@NiCo2O4 microspheres exhibit excellent electrochemical performance (a high reversible capacity of 1015 mA h g-1 after 100 cycles at a current density of 0.1 A g-1 and a high capacity of 805 mA h g-1 even at a high current density of 0...
November 23, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29222698/efficacy-evaluation-of-iclaprim-in-a-neutropenic-rat-lung-infection-model-with-methicillin-resistant-staphylococcus-aureus-entrapped-in-alginate-microspheres
#8
David B Huang, Ian Morrissey, Timothy Murphy, Stephen Hawser, Mark H Wilcox
The objective of this study was to demonstrate the efficacy of iclaprim in a neutropenic rat lung infection model with methicillin-resistant Staphylococcus aureus (MRSA) entrapped in alginate beads. An inoculum of 5.25 × 105 colony-forming units (CFU)/mL of S. aureus strain AH1252 was administered intratracheally to rats with prepared alginate bacteria suspensions. Beginning 2 h post-infection, rats received: (1) iclaprim 80 mg/kg (n = 16); (2) iclaprim 60 mg/kg (n = 16), or (3) vancomycin 50 mg/kg (n = 24), for 3 days via subcutaneous (SC) injection every 12 h...
December 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29221103/compensation-of-aberration-in-quantitative-phase-imaging-using-lateral-shifting-and-spiral-phase-integration
#9
Inhyeok Choi, KyeoReh Lee, YongKeun Park
We present a simple and effective method to eliminate system aberrations in quantitative phase imaging. Using spiral phase integration, complete information about system aberration is calculated from three laterally shifted phase images. The present method is especially useful when measuring confluent samples in which acquisition of background area is challenging. To demonstrate validity and applicability, we present measurements of various types of samples including microspheres, HeLa cells, and mouse brain tissue...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220575/dual-gated-microparticles-for-switchable-antibody-release
#10
Benedikt Ketterer, Huey Wen Ooi, Dominik Brekel, Vanessa Trouillet, Leonie Barner, Matthias Franzreb, Christopher Barner-Kowollik
We pioneer the design of dual-gated microparticles - both responsive to changes in temperature and pH - for stimuli-responsive chromatography targeted at the efficient separation of antibodies. Dual-gated microspheres were synthesized by introducing RAFT-based thiol-terminal block copolymers of poly(N-isopropylacrylamide-b-4-vinylpyridine) (P(NIPAM-b-4VP, 4 800 ≤ Mn / Da ≤ 10 000, featuring block length ratios of 29:7, 29:15, 29:30, respectively) by thiol-epoxy driven ligation to the surface of poly(glycidyl methacrylate) (PGMA) microparticles (10-12 µm), whereby the 4-vinylpyridine units within the lateral chain enable protein binding...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29218337/synthesis-and-photoelectrocatalytic-activity-of-in2o3-hollow-microspheres-via-a-bio-template-route-using-yeast-templates
#11
Duo Pan, Shengsong Ge, Xiyu Zhang, Xianmin Mai, Shengyao Li, Zhanhu Guo
Indium oxide (In2O3) hollow microspheres were prepared using yeast as a bio-template with the aid of a precipitation method. The yeast provided a solid frame for the deposition of In(OH)3 to form the precursor. The resulting In2O3 hollow microspheres were obtained by calcining the precursor at 650 °C. The samples were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption isotherms and UV-Vis diffuse reflectance spectroscopy...
December 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29217474/effect-of-particle-size-polydispersity-and-polymer-degradation-on-progesterone-release-from-plga-microparticles-experimental-and-mathematical-modeling
#12
Carlos Busatto, Juan Pesoa, Ignacio Helbling, Julio Luna, Diana Estenoz
Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of particle size, polydispersity and polymer degradation on the in vitro release of the hormone was studied. A triphasic release profile was observed for larger microparticles, while smaller microspheres showed a biphasic release profile...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29216604/digital-holographic-microscopy-for-3d-surface-characterization-of-polymeric-nanocomposites
#13
Vahid Abbasian, Ehsan A Akhlaghi, Mohammad A Charsooghi, Maasoomeh Bazzar, Ali-Reza Moradi
The aim of this paper is to introduce digital holographic microscopy (DHM) as a non-contact, inexpensive, and non-abrasive method for 3D surface characterization of polymeric nanocomposites. A common-path and vibration-immune Mirau system with a microsphere-assisted arrangement is utilized to increase the lateral resolution of the images. The characterization is performed through the measurement of roughness parameters of the surfaces, which are derived from the recorded holograms. Pure poly(triazole-amide-imide) (PTAI) and PTAI nanocomposite reinforeced with surface modified TiO2 nanoparticles (MN-TiO2) are used and compared...
November 28, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29215674/bioinspired-dynamic-microcapsules
#14
N F D AlDala'een, W N K W Mohamad, N Alias, A M Ali, J Shaikh Mohammed
There is an increasing interest in bioinspired dynamic materials. Abundant illustrations of protein domains exist in nature, with remarkable ligand binding characteristics and structures that undergo conformational changes. For example, calmodulin (CaM) can have three conformational states, which are the unstructured Apo-state, Ca2+-bound ligand-exposed binding state, and compact ligand-bound state. CaM's mechanical response to biological cues is highly suitable for engineering dynamic materials. The distance between CaM globular terminals in the Ca2+-bound state is 5 nm and in the ligand-bound state is 1...
December 7, 2017: Soft Matter
https://www.readbyqxmd.com/read/29215558/synthesis-of-benzyl-acetate-catalyzed-by-lipase-immobilized-in-nontoxic-chitosan-polyphosphate-beads
#15
Ana D Q Melo, Francisco F M Silva, José C S Dos Santos, Roberto Fernández-Lafuente, Telma L G Lemos, Francisco A Dias Filho
Enzymes serve as biocatalysts for innumerable important reactions, however, their application has limitations, which can in many cases be overcome by using appropriate immobilization strategies. Here, a new support for immobilizing enzymes is proposed. This hybrid organic-inorganic support is composed of chitosan-a natural, nontoxic, biodegradable, and edible biopolymer-and sodium polyphosphate as the inorganic component. Lipase B from Candida antarctica (CALB) was immobilized on microspheres by encapsulation using these polymers...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29211344/preparation-of-silica-microspheres-with-a-broad-pore-size-distribution-and-their-use-as-the-support-for-a-coated-cellulose-derivative-chiral-stationary-phase
#16
Mingxian Huang, Hongyan Ma, Mengna Niu, Fei Hu, Shige Wang, Lulu Li, Chunguang Lv
A templating strategy using crosslinked and functionalized polymeric beads to synthesize silica microspheres with a broad pore size distribution has been developed. The polymer/silica hybrid microspheres were prepared by utilizing the combination of a templating weak cation exchange resin, a structure-directing agent N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride, and a silica precursor tetraethyl orthosilicate. The silica microspheres were then obtained after calcining the hybrid microspheres. The as-prepared materials were characterized by scanning electron microscopy, mercury intrusion porosimeter, and thermal gravimetric analysis...
December 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29210975/multi-center-evaluation-of-a-new-electrochemiluminescence-immunoassay-eclia-for-everolimus-concentrations-in-whole-blood
#17
Alain G Verstraete, Raül Rigo-Bonnin, Pierre Wallemacq, Michael Vogeser, Andre Schuetzenmeister, Christian Schmiedel, Maria Shipkova
BACKGROUND: The precise monitoring of everolimus, an immunosuppressant drug, is vital for transplant recipients due to its narrow therapeutic range. This study evaluated the analytical performance of a new electrochemiluminescence immunoassay (ECLIA) for everolimus concentrations in whole blood. METHODS: Accuracy, imprecision, and sensitivity studies for the Roche Elecsys everolimus ECLIA were performed at five European laboratories. The ECLIA was compared with liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods, as well as the Quantitative Microsphere System (QMS) everolimus assay...
November 28, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29210565/a-microsphere-na0-65-ni0-17co0-11mn0-72-o2-cathode-material-for-high-performance-sodium-ion-batteries
#18
Tae-Yeon Yu, Jang-Yeon Hwang, Doron Aurbach, Yang-Kook Sun
P2-type layered oxides have been considered promising candidates as cathodes for sodium-ion batteries owing to their high capacity and high rate capability. However, due to the difficulty involved in forming hierarchical microstructures, it remains challenging to develop high energy density P2-type layered oxides with good electrochemical performance and high electrode density. In this study, we demonstrate the feasibility of P2-type Na0.65[Ni0.17Co0.11Mn0.72]O2 as a very efficient cathode material for high energy density sodium-ion batteries by synthesizing a micron-sized hierarchical structure via the co-precipitation route...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29209740/early-deficits-in-insulin-secretion-beta-cell-mass-and-islet-blood-perfusion-precede-onset-of-autoimmune-type-1-diabetes-in-biobreeding-rats
#19
Anya Medina, Saba Parween, Sara Ullsten, Neelanjan Vishnu, Yuk Ting Siu, My Quach, Hedvig Bennet, Alexander Balhuizen, Lina Åkesson, Nils Wierup, Per Ola Carlsson, Ulf Ahlgren, Åke Lernmark, Malin Fex
AIMS/HYPOTHESIS: Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS: We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneous autoimmune type 1 diabetes) and diabetes-resistant DRLyp/+ and DR+/+ littermates (controls) to investigate beta cell function in vivo, and insulin and glucagon secretion in vitro...
December 6, 2017: Diabetologia
https://www.readbyqxmd.com/read/29209627/thermosensitive-chitosan-hydrogels-containing-polymeric-microspheres-for-vaginal-drug-delivery
#20
Ting-Ting Yang, Yuan-Zheng Cheng, Meng Qin, Yong-Hong Wang, Hong-Li Yu, An-Lin Wang, Wei-Fen Zhang
Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug loading (DL). The physicochemical properties of the optimal MS (MS F) were characterized...
2017: BioMed Research International
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