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https://www.readbyqxmd.com/read/28822143/-research-progress-of-rapid-detection-of-ochratoxin-a-and-its-application-prospect-in-traditional-chinese-medicine
#1
REVIEW
Shu-Rong Hu, Guang-Yao Ying, Yu-Li Hu, Shi-Hai Yang, Mei-Hua Yang
Ochratoxin A (OTA) is a toxic secondary metabolite mainly produced by Aspergillus and Penicillium species, with strong renal toxicity, teratogenic, carcinogenic, mutagenic effect. Studies have shown that OTA is not only widely contaminated in food and feed crops, but also has been widely contaminated in Chinese herbal medicines such as spices, licorice and so on. In view of OTA's universality and harmfulness, this paper summarizes the flow visualization test strip, microsphere, electrochemical sensor, surface enhanced Raman spectroscopy technology in OTA rapid detection, which provides reference for the research and application of high throughout detection instrument miniaturization in order to achieve OTA quick detection and simple operation...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821135/exploring-pullulan-poly-vinyl-alcohol-interpenetrating-network-microspheres-as-controlled-release-drug-delivery-device
#2
Saundray Raj Soni, Animesh Ghosh
In the present study, interpenetrating polymeric network (IPN) microsphere was prepared using glutaraldehyde assisted water-in-oil emulsion crosslinking method for controlled delivery of pirfenidone, the only chemical entity approved by US FDA for the treatment of Idiopathic Pulmonary Fibrosis (IPF). In our study, the natural biopolymer pullulan was harnessed in combination with synthetic polymer PVA for drug delivery applications. The prepared microspheres were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, solid state (13)C nuclear magnetic resonance and field emission scanning electron microscopy...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821089/preparation-and-evaluation-of-chitosan-alginate-porous-microspheres-bletilla-striata-polysaccharide-composite-hemostatic-sponges
#3
Chao Wang, Wenfeng Luo, Puwang Li, Sidong Li, Ziming Yang, Zhang Hu, Yangyang Liu, Ningjian Ao
We prepared a novel hemostatic material using chitosan (CS), alginate, and Bletilla striata, which showed good biocompatibility and hemostatic properties. Alginate-calcium porous microspheres (Alg) were prepared by emulsification/cross-linking methods, and Bletilla striata polysaccharide (Bsp) was extracted from the tubers by water extraction and alcohol precipitation. To improve the water absorption and accelerate the blood coagulation, Alg and Bsp were mixed with chitosan solution to form CS/Alg and CS/Alg/Bsp composite sponges by lyophilization...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821068/radiation-synthesis-and-performance-of-novel-cellulose-based-microsphere-adsorbents-for-efficient-removal-of-boron-iii
#4
Siqi Liu, Min Xu, Tianlin Yu, Dong Han, Jing Peng, Jiuqiang Li, Maolin Zhai
A novel cellulose-based microsphere containing glucamine groups, referred as CVN, was successfully synthesized by radiation-induced graft polymerization of 4-vinylbenzyl chloride onto cellulose microspheres and subsequent functionalization with N-methyl-d-glucamine. The adsorption by CVN for boron (III) from aqueous solutions was evaluated systematically by batch adsorption technique. Langmuir models could fit well with the adsorption behavior of CVN. The CVN adsorbents exhibited a high adsorption capacity up to 12...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28819566/development-of-poly-lactic-glycolic-acid-plga-microspheres-for-controlled-release-of-rho-associated-kinase-inhibitor
#5
Sho Koda, Naoki Okumura, Junji Kitano, Noriko Koizumi, Yasuhiko Tabata
PURPOSE: The purpose of this study was to investigate the feasibility of poly lactic/glycolic acid (PLGA) as a drug delivery carrier of Rho kinase (ROCK) inhibitor for the treatment of corneal endothelial disease. METHOD: ROCK inhibitor Y-27632 and PLGA were dissolved in water with or without gelatin (W1), and a double emulsion [(W1/O)/W2] was formed with dichloromethane (O) and polyvinyl alcohol (W2). Drug release curve was obtained by evaluating the released Y-27632 by using high performance liquid chromatography...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28819134/long-term-glaucoma-drug-delivery-using-a-topically-retained-gel-microsphere-eye-drop
#6
Morgan V Fedorchak, Ian P Conner, Joel S Schuman, Anthony Cugini, Steven R Little
The purpose of this study was to characterize and determine the efficacy of a long-term, non-invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is comprised of a thermoresponsive hydrogel carrier and drug-loaded polymer microspheres. In vitro release of brimonidine from the GMS drops and gel properties were quantified. A single brimonidine-loaded GMS drop was administered to 5 normotensive rabbits and intraocular pressure (IOP) was monitored for 28 days. Here we report that IOP reduction in rabbits receiving a single brimonidine GMS drop was comparable to that of rabbits receiving twice daily, standard brimonidine drops...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818598/serotype-determination-of-salmonella-by-xtag-assay
#7
Zhibei Zheng, Wei Zheng, Haoqiu Wang, Jincao Pan, Xiaoying Pu
Currently, no protocols or commercial kits are available to determine the serotypes of Salmonella by using Luminex MAGPIX®. In this study, an xTAG assay for serotype determination of Salmonella suitable for Luminex MAGPIX® is described and 228 Salmonella isolates were serotype determined by this xTAG assay. The xTAG assay consists of two steps: 1) Multiplex PCR to amplify simultaneously O, H and Vi antigen genes of Salmonella, and 2) Magplex-TAG™ microsphere hybridization to identify accurately the specific PCR products of different antigens...
August 14, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28816311/hierarchical-core-shell-sio2-pda-biobr-microspheres-with-enhanced-visible-light-driven-photocatalytic-performance
#8
Shuai-Ru Zhu, Qi Qi, Wen-Na Zhao, Meng-Ke Wu, Yuan Fang, Kai Tao, Fei-Yan Yi, Lei Han
To explore catalysts combining highly accessible specific surface areas with low recombination of the photo-induced electron-hole pairs, a novel SiO2@PDA@BiOBr composite photocatalyst with a hierarchical core-shell structure was prepared by a facile solvothermal method. The catalyst shows a superior performance on photodegradation of Rhodamine B under visible light irradiation, especially for SiO2@PDA-2@BiOBr with the reactant kinetics constant (k = 0.0487 min(-1)). The enhanced photocatalytic performance of SiO2@PDA-2@BiOBr was ascribed to the decreased band-gap, higher surface area, and effectively photo-generated electron-hole pairs by the introduction of polydopamine (PDA)...
August 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28814735/self-assembly-of-ternary-hollow-microspheres-with-strong-wideband-microwave-absorption-and-controllable-microwave-absorption-properties
#9
Qiang Zeng, Ping Chen, Qi Yu, Hai-Rong Chu, Xu-Hai Xiong, Dong-Wei Xu, Qi Wang
In this study, we report a simple and efficient two-step method consisting of water-in-oil (W/O) emulsion technique and subsequent annealing process for synthesizing the hollow reduced graphene oxide microspheres embedded with Co nanoparticles (Air@rGO€Co). The microspheres showed good electromagnetic properties because of the coexistence of magnetic loss and dielectric loss to microwaves. The minimum reflection loss (RLmin) value of S1.5 reaches -68.1 dB at 13.8 GHz with a thickness of 2.2 mm, and the absorption bandwidth (lower than -10 dB) is 7...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814229/cell-mediated-and-humoral-immune-responses-to-bordetella-pertussis-inactivated-whole-cells-encapsulated-alginate-microspheres-as-a-new-vaccine-candidate
#10
Naser Mohammadpour Dounighi, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli, Hossein Zolfagharian
BACKGROUND: Effectiveness of the whole-cell pertussis vaccine is apparent, but improvement in the quality of the vaccine is necessary to achieve strong immunogenicity with a low bacterial number content. METHODS: The inactivated Bordetella pertussis (B. pertussis) cells entrapped microspheres were prepared via an emulsification method and analyzed for morphology, size, size distribution, loading efficiency, loading capacity, release kinetic, in vivo cytokines and antigen specific antibody subclasses...
August 15, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28812894/enhanced-production-of-%C3%AE%C2%BA-carrageenase-and-%C3%AE%C2%BA-carrageenan-oligosaccharides-through-immobilization-of-thalassospira-sp-fjfst-332-with-magnetic-fe3o4-chitosan-microspheres
#11
Juanjuan Guo, Zhichang Zheng, Chi Chen, Xu Lu, Yi Zhang, Baodong Zheng
In this study, immobilized bacteria (IMB) microsphere was prepared by embedding κ-carrageenase-producing Thalassospira sp.Fjfst-332 (TF332) onto a magnetic Fe3O4-chitosan carrier. The performance of Fe3O4-chitosan carrier was optimized by comparing their bacteria immobilization capacity at different Fe3O4:chitosan ratios and temperatures, while the functions of IMB microspheres were characterized by examining their κ-carrageenase production at different temperatures, pH, and reuse cycles. At the 1:1 (w:w) Fe3O4:chitosan ratio, the Fe3O4-chitosan carriers possessed sufficient anchoring capacity for bacterial immobilization without significant compromise of their magnetism for magnetic separation of IMB from culture media...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28810633/clinical-significance-of-5-and-6-carboxyfluorescein-diacetate-succinimidyl-ester-labeled-microspheres-for-detecting-endothelial-progenitor-cells-in-human-peripheral-blood
#12
Chaolin Qiu, Denghai Zhang, Yongbin Chi, Qing Chen, Limin Xu, Qiuhua Xie
The aims of the present study were to establish a single-platform flow cytometry method using 5-(and 6)-carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeled microspheres as the reference for determining endothelial progenitor cell (EPC) number and to evaluate the efficacy of this detection method. Single-platform flow cytometry was used to count cell numbers using CFSE-stained fluorescent microspheres as the internal reference and the EPC numbers in specimens using this novel method were compared with an in vitro clonogenic counting assay...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809501/microencapsulated-solid-lipid-nanoparticles-as-a-hybrid-platform-for-pulmonary-antibiotic-delivery
#13
Diana P Gaspar, Maria Manuela Gaspar, Carla V Eleutério, Ana Grenha, Mateo Blanco, Lídia M D Gonçalves, Pablo Taboada, António J Almeida, Carmen Remuñán-López
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in microspheres of appropriate size using suitable excipients (mannitol and trehalose) through a spray-drying technique. Confocal analysis microscopy showed that microspheres are spherical and that SLN are efficiently microencapsulated and homogeneously distributed throughout the microsphere matrices...
August 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28809160/w-n-tio2-with-positive-enough-level-of-valence-band-maximum-and-narrowing-bandgap-for-selective-aerobic-oxidation-in-visible-light-irradiation
#14
Mingming Zou, Lu Feng, Zhang Bingxue, Xinxin Zhou, Minghui Yang
A kind of surface complex (Triethylamine and mesoporous W-N-TiO2 microspheres with large surface area: 117.5 m2g-1) catalysis were achieved via visible-light photoredox catalysis. Triethylamine behaves as a true redox mediator due to donating ability seems to be highly favorable. With lower bandgap (2.43 eV) and more positive level of VBM (2.905 V), W-N-TiO2 sample has ability to play active catalytic role yielding excellent conversion of the selective oxidation of thioanisole (75.16 %) within 12 h visible light irradiation...
August 15, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28809101/a-microsphere-supported-lipid-bilayer-platform-for-dna-reactions-on-a-fluid-surface
#15
Aurora Fabry-Wood, Madalyn Elise Fetrow, Carl W Brown Iii, Nicholas A Baker, Nadiezda Fernandez Oropeza, Andrew P Shreve, Gabriel A Montano, Darko Stefanovic, Matthew R Lakin, Steven W Graves
We report a versatile microsphere-supported lipid bilayer system that can serve as a general-purpose platform for implementing DNA nanotechnologies on a fluid surface. To demonstrate our platform, we implemented both toehold-mediated strand displacement (TMSD) and DNAzyme reactions, which are typically performed in solution and which are the cornerstone of DNA-based molecular logic and dynamic DNA nanotechnology, on the surface. We functionalized microspheres bearing supported lipid bilayers (µSLBs) with membrane-bound nucleic acid components...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28808332/magnetic-microsphere-based-portable-solid-phase-extraction-device-for-on-site-pre-concentration-of-organics-from-large-volume-water-samples
#16
Zhijian Yao, Qingqing Zhao, Yan Ma, Wei Wang, Qing Zhou, Aimin Li
In this research a new magnetic material called M88 was fully synthetized and characterized for the extraction of pharmaceutical and personal care products in water samples. In addition, a portable prototype of magnetic solidphase extraction (MSPE) device was developed for the onsite preconcentration. The MSPE coupling with high performance liquid chromatography-Diode array detector (HPLC-DAD) method was developed and validated for simultaneous analysis of 11 PPCPs (mefenamic acid, chloroamphenicol, ketoprofen, clofibric acid, indometacin, acetylsalicylic acid, bisphenol A, phenylphenol, gemfibrozil, triclosan, and ibuprofen) in environmental water samples...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806665/a-sequential-delivery-system-employing-the-synergism-of-epo-and-ngf-promotes-sciatic-nerve-repair
#17
Wei Zhang, Gongshe Zhou, Yuan Gao, Yan Zhou, Jianheng Liu, Licheng Zhang, Anhua Long, Lihai Zhang, Peifu Tang
The different mechanisms of nerve growth factor (NGF) and erythropoietin (EPO) in promoting repair of peripheral nerve injuries suggest a potential therapeutic application through the synergism of the two. Yet NGF has also been reported to induce early nerve apoptosis after injury. To utilize the potential synergism of NGF and EPO while minimize the possible defect, in this study, we first confirmed the time dependency of NGF caused nerve apoptosis, and then established a sequential and sustained delivery system for NGF and EPO with poly(lactide-co-glycolide) (PLGA), which has been approved by the US FDA for human use because of its injectable, biocompatible, and biodegradable properties...
August 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28806060/a-smart-dna-machine-for-carcinoembryonic-antigen-detection-by-exonuclease-iii-assisted-target-recycling-and-dna-walker-cascade-amplification
#18
Mengqi He, Kun Wang, Wen-Jing Wang, Yong-Liang Yu, Jian-Hua Wang
Synthetic DNA machine performs quasi-mechanical movements in response to external intervention, suggesting the promise of constructing sensitive and specific biosensors. Herein, a smart DNA walker biosensor for label-free detection of carcinoembryonic antigen (CEA) is developed for the first time by a novel cascade amplification strategy of exonuclease (Exo) III-assisted target recycling (ERA) and DNA walker. ERA as the first stage of amplification generates the walker-DNA, while the autonomous traveling of the walker-DNA on the substrate-modified silica microspheres as the second stage of amplification produces an ultrasensitive fluorescent signal with the help of N-methylmesoporphyrin IX (NMM)...
August 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28804597/size-and-concentration-analyses-of-extracellular-vesicles-by-nanoparticle-tracking-analysis-a-variation-study
#19
Beate Vestad, Alicia Llorente, Axl Neurauter, Santosh Phuyal, Bente Kierulf, Peter Kierulf, Tore Skotland, Kirsten Sandvig, Kari Bente F Haug, Reidun Øvstebø
Current methods for characterisation of extracellular vesicles (EVs) need further standardisation in order to obtain an acceptable level of data comparability. Size and concentration of EVs can be determined by nanoparticle tracking analysis (NTA). However, both the heterogeneity of EVs and the choice of instrument settings may cause an appreciable analytical variation. Intra-assay (within-day, n = 6) and inter-assay (day-to-day, n = 6) variations (coefficient of variation, % CV) of different preparations of EVs and artificial vesicles or beads were determined using two NanoSight NS500 instruments, located at different laboratories...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28803481/autonomous-collision-free-navigation-of-microvehicles-in-complex-and-dynamically-changing-environments
#20
Tianlong Li, Xiaocong Chang, Zhiguang Wu, Jinxing Li, Guangbin Shao, Xinghong Deng, Jianbin Qiu, Bin Guo, Guangyu Zhang, Qiang He, Longqiu Li, Joseph Wang
Self-propelled micro- and nanoscale robots represent a rapidly emerging and fascinating robotics research area. However, designing autonomous and adaptive control systems for operating micro-/nanorobotics in complex and dynamically-changing environments, which is a highly demanding feature, is still an unmet challenge. Here we describe a smart microvehicle for precise autonomous navigation in complicated environments and traffic scenarios. The fully autonomous navigation system of the smart microvehicle is composed of a microscope-coupled CCD camera, an artificial intelligence planner, and a magnetic field generator...
August 12, 2017: ACS Nano
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