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Philip G Conaghan, David J Hunter, Stanley B Cohen, Virginia B Kraus, Francis Berenbaum, Jay R Lieberman, Deryk G Jones, Andrew I Spitzer, David S Jevsevar, Nathaniel P Katz, Diane J Burgess, Joelle Lufkin, James R Johnson, Neil Bodick
BACKGROUND: Intra-articular corticosteroids relieve osteoarthritis pain, but rapid systemic absorption limits efficacy. FX006, a novel, microsphere-based, extended-release triamcinolone acetonide (TA) formulation, prolongs TA joint residence and reduces systemic exposure compared with standard TA crystalline suspension (TAcs). We assessed symptomatic benefits and safety of FX006 compared with saline-solution placebo and TAcs. METHODS: In this Phase-3, multicenter, double-blinded, 24-week study, adults ≥40 years of age with knee osteoarthritis (Kellgren-Lawrence grade 2 or 3) and average-daily-pain (ADP)-intensity scores of ≥5 and ≤9 (0 to 10 numeric rating scale) were centrally randomized (1:1:1) to a single intra-articular injection of FX006 (32 mg), saline-solution placebo, or TAcs (40 mg)...
April 18, 2018: Journal of Bone and Joint Surgery. American Volume
Ya-Nan Fu, Yongsan Li, Guofeng Li, Lei Yang, Qipeng Yuan, Lei Tao, Xing Wang
No abstract text is available yet for this article.
April 17, 2018: Biomacromolecules
Ruiyang Wu, Hongbo Song, Nan Luo, Guijuan Ji
A novel 3D flower-like BiPO4 /Bi2 WO6 photocatalyst was prepared using hydrothermal method. The crystal structure, surface morphologies and optical properties of the samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) and Ultraviolet-visible diffuse reflectance spectrum (UV-vis DRS). The photocatalytic activity of the BiPO4 /Bi2 WO6 composites was evaluated by using rhodamine B (RhB) as a target organic pollutant under visible light irradiation...
March 12, 2018: Journal of Colloid and Interface Science
Xiaoqin Zhang, Yuting Zhang, Caiyun Fang, Lei Zhang, Pengyuan Yang, Changchun Wang, Haojie Lu
Palmitoylation, a type of fatty acylation, has vital roles in many biological processes. For ultra-deep identification of protein palmitoylation, an enrichment approach based on a novel magnetic microsphere modified with 2,2'-dithiodipyridine (Fe3O4/SiO2-SSPy microsphere) was presented in this study. The Fe3O4/SiO2-SSPy microspheres were synthesized by directly coating thiol-containing silane coupling agent onto the magnetic supraparticles in aqueous solution at room temperature. Due to the intrinsic magnetic properties, high surface-to-volume ratios and abundant reactive functional groups on surface, these microspheres enabled direct capture of palmitoylated targets and convenient isolation, contributing to remarkable enrichment selectivity (purifying palmitoylated peptides from mixtures with non-palmitoylated peptides even at a 1:500 molar ratio) and sensitivity (the detection limit was at fmol level), thus enables a global annotation of protein palmitoylation for complex biological samples...
April 16, 2018: Analytical Chemistry
Lifeng Chen, Xianyan Yang, Rui Ma, Linghua Zhu
<b>Objective:</b> To evaluate the application of mechanically reinforced 45S5 Bioglass<sup>®</sup>-derived glass ceramic porous scaffolds for repair of bone defect in rabbits. <b>Methods:</b> The BG-ZnB powders were added into the 45S5 Bioglass<sup>®</sup> powder/paraffin microsphere mixtures and were sintered at 900℃ to obtain porous scaffolds with highly bioactive BG-ZnB of 0%, 2% or 4% of mass fraction (denoted as 45S5/ZnB0, 45S5/ZnB2, 45S5/ZnB4). Phase composition, porosity and compression properties of three kinds of as-sintered scaffolds were characterized by X-ray analysis, mercury porosimetry, and mechanical test...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Juan Song, Ran Wang, Zao Liu, Huashan Zhang
The influence of lecithin from egg yolk (LE) on calcium carbonate (CaCO3) biomineralization was investigated. In the present study, spherical CaCO3 particles were synthesized via coprecipitation in the presence of LE. LE multilamellar liposomes were first tuned by sonication to provide better control over the nucleation of CaCO3. Subsequently, monodisperse microspheres ~2 µm in size were generated by controlling the aggregation and growth of CaCO3 under appropriate concentrations of LE. In contrast to unstable vaterite, the microspheres generated in aqueous solution remained stable for at least 10 days without transforming into calcite, due to the strong interaction between the LE and calcium ions...
April 12, 2018: Molecular Medicine Reports
Xin Zhang, Fei Liu, Karla-Anne Knapp, Michael L Nickels, H Charles Manning, Leon M Bellan
Herein, we report the development of a simple, high-throughput and efficient microfluidic system for synthesizing radioactive [18F]fallypride, a PET imaging radiotracer widely used in medical research. The microfluidic chip contains all essential modules required for the synthesis and purification of radioactive fallypride. The radiochemical yield of the tracer is sufficient for multiple animal injections for preclinical imaging studies. To produce the on-chip concentration and purification columns, we employ a simple "trapping" mechanism by inserting rows of square pillars with predefined gaps near the outlet of microchannel...
April 16, 2018: Lab on a Chip
Yang-Yang Ma, Wen-Xian Li, Yu-Shan Zheng, Jin-Rong Bao, Yi-Lian Li, Li-Na Feng, Kui-Suo Yang, Yan Qiao, An-Ping Wu
Two novel core-shell structure ternary terbium composites SiO2(600) @Tb(MABA-Si)·L(L:dipy/phen) nanometre luminescence materials were prepared by ternary terbium complexes Tb(MABA-Si)·L2 ·(ClO4 )3 ·2H2 O shell grafted onto the surface of SiO2 microspheres. And corresponding ternary terbium complexes were synthesized using (CONH(CH2 )3 Si(OCH2 CH3 )3 )2 (denoted as MABA-Si) as first ligand and L as second ligand coordinated with terbium perchlorate. The as-synthesized products were characterized by means of IR spectra, 1 HNMR, element analysis, molar conductivity, SEM and TEM...
March 2018: Royal Society Open Science
Yao Lu, Deliang He, Huibin Lei, Jun Hu, Houqiang Huang, Huiying Ren
Taro stalks (TS) were modified by diethylenetriamine (DETA) to obtain the modified taro stalks adsorbents (recorded as MTSA). This kind of raw material is unprecedented and the method of modification is relatively simple. The physicochemical properties of MTSA were characterized by scanning electron microscope (SEM), FTIR, and zeta potential analyzer. The capacity of MTSA for adsorbing heavy metals under different influencing factors was tested by UV-visible spectrophotometer. The results indicated that the gaps between the microspheres of MTSA are more, which are conducive to adsorption...
April 14, 2018: Environmental Science and Pollution Research International
Chu-Ya Wang, Xing Zhang, Qing Rong, Nan-Nan Hou, Han-Qing Yu
Ammonia (NH3 ), is a precursor for the formation of atmospheric fine particulate matter (PM2.5 ), and thus establishing efficient and cost-effective methods to detect ammonia emission is highly desired. Transition metal oxide semiconductors-based sensors for electrochemical gas sensing have been extensively explored. Among various types of semiconductors, tungsten oxide (WO3 ) possesses an anisotropic layered crystalline structure and is recognized as a promising material for gas sensing. However, the performance of commercial WO3 is unsatisfactory because of its high impedance and low charge transportation efficiency...
April 10, 2018: Chemosphere
Meng Gao, Jianwei Fu, Minghuan Wang, Kai Wang, Shaomin Wang, Zhiwei Wang, Zhimin Chen, Qun Xu
Development of facile and cost-effective routes to achieve hierarchical porous and heteroatoms-doped carbon architectures is urgently needed for high-performance supercapacitor application. In our study, ternary-doped (nitrogen, phosphorus and oxygen) hollow carbon microspheres (NPO-HCSs) are fabricated by one-step pyrolysis of single poly(cyclotriphosphazene-co-phloroglucinol) (PCPP) microsphere, which is generated through a facile polymerization between hexachlorocyclotriphosphazene and phloroglucinol at mild conditions...
April 6, 2018: Journal of Colloid and Interface Science
Azmat Ali Khan, Amer M Alanazi, Mumtaz Jabeen, Shahnavaj Khan, Abdul Mallik
Cryptococcus neoformans is one of the most lethal fungi causing mortality across the globe with the highest incidences in immuno-compromised person. Patients taking immuno-suppressive medications and immuno-competent hosts are extremely susceptible to its infection. Thus, new forms of therapy are urgently required for effective cure to the fungal burden. So, in the present study we have tried to explore the potential effects of amphotericin B (AMB) and fluconazole (FLC) in combination antifungal drug therapy...
April 10, 2018: European Journal of Pharmaceutical Sciences
Fengdong Qu, Wenan Shang, Dongting Wang, Shiyu Du, Tiju Thomas, Shengping Ruan, Minghui Yang
Multi-shell, stable, porous metal-oxide microspheres (Ni-Co oxides, Co3O4 and NiO) have been synthesized through amorphous-coordination-polymers based self-templated method. Both oxides of Ni and Co show poor selectivity to xylene, but the composite phase has substantial selectivity (eg. Sxylene/Sethanol = 2.69), and remarkable sensitivity (11.5 to 5 ppm xylene at 255 oC). The short response and recovery times (6 and 9 seconds), excellent humidity-resistance performance (with coefficient of variation = 11.4 %), good cyclability and long-term stability (sensitivity attenuation of ~9...
April 13, 2018: ACS Applied Materials & Interfaces
Aleksander Shakhov, Artyom Astafiev, Viktor Nadtochenko
We report the effect of laser cavitation in water initiated by femtosecond pulses confined into subwavelength volume of photonic nanojet of spherical microparticles. The effect of nanoscale optical breakdown was employed for controllable and nondestructive micromanipulation of silica microspheres. We combine this technique with optical trapping for cyclic particle movements and estimate a peak velocity and an acceleration acquired by microspheres propelled by nanojet cavitation. Our study provides a strategy for nondestructive optical micromanipulation, cavitation-assisted drug delivery, and laser energy transduction in microdevices...
April 15, 2018: Optics Letters
Keith T Chan, Adam M Alessio, Guy E Johnson, Sandeep Vaidya, Sharon W Kwan, Wayne Monsky, Ann E Wilson, David H Lewis, Siddharth A Padia
PURPOSE: To define a threshold radiation dose to non-tumoral liver from 90 Y radioembolization that results in hepatic toxicity using pair-production PET. MATERIALS AND METHODS: This prospective single-arm study enrolled 35 patients undergoing radioembolization. A total of 34 patients (27 with HCC and 7 with liver metastases) were included in the final analysis. Of 27 patients with underlying cirrhosis, 22 and 5 patients were Child-Pugh A and B, respectively. Glass and resin microspheres were used in 32 (94%) and 2 (6%) patients, respectively...
April 12, 2018: Cardiovascular and Interventional Radiology
Gayatri P Gautam, Tobias Burger, Andrew Wilcox, Michael J Cumbo, Steven W Graves, Menake E Piyasena
We introduce a new method to construct microfluidic devices especially useful for bulk acoustic wave (BAW)-based manipulation of cells and microparticles. To obtain efficient acoustic focusing, BAW devices require materials that have high acoustic impedance mismatch relative to the medium in which the cells/microparticles are suspended and materials with a high-quality factor. To date, silicon and glass have been the materials of choice for BAW-based acoustofluidic channel fabrication. Silicon- and glass-based fabrication is typically performed in clean room facilities, generates hazardous waste, and can take several hours to complete the microfabrication...
April 12, 2018: Analytical and Bioanalytical Chemistry
Shaoqi Qu, Cunchun Dai, Jiajia Zhu, Li Zhao, Yuwen Li, Zhihui Hao
The aim of this study was to prepare cefquinome-loaded polylactic acid microspheres and to evaluate their in vitro and in vivo characteristics and pharmacodynamics for the therapy of pneumonia in a rat model. Microspheres were prepared using a 0.7 mm two-fluid nozzle spray drier in one step resulting in spherical and smooth microspheres of uniform size (9.8 ± 3.6 μm). The encapsulation efficiency and drug loading of cefquinome were 91.6 ± 2.6% and 18.7 ± 1.2%, respectively. In vitro release of cefquinome from the microspheres was sustained for 36 h...
November 2018: Drug Delivery
Xinfeng Du, Liyuan Yang, Wenchang Hu, Renjie Wang, Jingying Zhai, Xiaojiang Xie
Nanoscale ionophore-based ion-selective optodes (nano-ISOs) are effective sensing tools for in situ and real time measurements of ion concentrations in biological and environmental samples. While searching for novel sensing materials, nano-ISOs free of plasticizers are particularly important for biological and environmental applications. This work described plasticizer-free nano-ISOs based on Si-containing particles including PEGylated organosilica nanoparticle, PDMS nanospheres and SiO2 microspheres, with diameters around 50 nm, 100 nm, and 5 μm, respectively...
April 13, 2018: Analytical Chemistry
Di Peng, Xiang Liu, Mengjun Huang, Dan Wang, Renlong Liu
Solid powder fluorescence shows great potential for application in medicine, biology, and engineering, especially in the identification of latent fingermarks in forensic science. However, conventional developing methods suffer from some drawbacks, such as low contrast, low sensitivity, low selectivity, and high toxicity. To conquer these challenges, novel SiO2@C-dot microspheres were prepared via a facile one-pot hydrothermal method by using citric acid as a carbon source and aminosilane as a nitrogen source...
April 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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