keyword
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#1
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38535571/porcine-monocyte-dna-traps-formed-during-infection-with-pathogenic-clostridioides-difficile-strains
#2
JOURNAL ARTICLE
Jade Lawrence, Paul Barrow, Neil Foster
Clostridioides ( Clostridium ) difficile is an enteric pathogen of several mammalian species including man, frequently involving nosocomial resurgence, following oral administration of broad-spectrum antibiotics, but also with human-to-human infection occurring, and neonatal pigs with zoonotic transmission. To date, the immune response to C . difficile has mostly focused on neutrophils and cytokine/chemokines, particularly in human infection. The neonatal pig is now recognized as a valuable model for human infection...
March 5, 2024: Pathogens
https://read.qxmd.com/read/38535096/neutrophil-extracellular-traps-nets-and-atherosclerosis-does-hypolipidemic-treatment-have-an-effect
#3
REVIEW
Petros Spyridonas Adamidis, Despoina Pantazi, Iraklis C Moschonas, Evangelos Liberopoulos, Alexandros D Tselepis
Neutrophil extracellular traps (NETs) have attracted much attention recently, beyond elemental host immunity, due to their fundamental implication in a variety of pathologic conditions and widespread impactful diseases. Atherosclerotic cardiovascular disease (ASCVD) is one of them, and a major cause of mortality and disability worldwide. Consequently, years of basic and clinical research were dedicated to shedding light on every possible pathophysiologic mechanism that could be used as an effective prevention and treatment tool to ameliorate its burden...
February 21, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38533319/corrigendum-what-is-the-role-of-the-neutrophil-extracellular-traps-in-the-cardiovascular-disease-burden-associated-with-hemodialysis-bioincompatibility
#4
Jean-Paul Cristol, Alain R Thierry, Anne-Sophie Bargnoux, Marion Morena-Carrere, Bernard Canaud
[This corrects the article DOI: 10.3389/fmed.2023.1268748.].
2024: Frontiers in Medicine
https://read.qxmd.com/read/38531056/neutrophil-functions-in-patients-with-neutropenia-due-to-glycogen-storage-disease-type-1b-treated-with-empagliflozin
#5
JOURNAL ARTICLE
Magdalena Kaczor, Stanislaw Malicki, Justyna Folkert, Ewelina Dobosz, Danuta Bryzek, Barbara Chruścicka-Smaga, Milena Greczan, Dorota Wesół-Kucharska, Barbara Piatosa, Emilia Samborowska, Joanna Madzio, Janusz Książyk, Ewa Ehmke Vel Emczyńska, Małgorzata Hajdacka, Jan Potempa, Wojciech Młynarski, Dariusz Rokicki, Florian Veillard
Neutropenia and neutrophil dysfunction in glycogen storage disease type 1b (GSD1b) are caused by the accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) in granulocytes. The antidiabetic drug empagliflozin reduces the concentration of 1,5-anhydroglucitol (1,5 AG), thus restoring neutrophil counts and functions, leading to promising results in previous case reports. Here, we present a comprehensive analysis of neutrophil function in seven GSD1b patients and 11 healthy donors, aiming to evaluate the immediate (after 3 months) and long-term (after 12 months) efficacy of empagliflozin compared to the reference treatment with granulocyte-colony stimulating factor (G-CSF)...
March 26, 2024: Blood Advances
https://read.qxmd.com/read/38529365/neutrophil-extracellular-traps-in-tumors-and-potential-use-of-traditional-herbal-medicine-formulations-for-its-regulation
#6
REVIEW
Xiang Li, Lei Hu, Abid Naeem, Shanghua Xiao, Ming Yang, Hongming Shang, Jing Zhang
Neutrophil extracellular traps (NETs) are extracellular fibers composed of deoxyribonucleic acid (DNA) and decorated proteins produced by neutrophils. Recently, NETs have been associated with the development of many diseases, including tumors. Herein, we reviewed the correlation between NETs and tumors. In addition, we detailed active compounds from traditional herbal medicine formulations that inhibit NETs, related nanodrug delivery systems, and antibodies that serve as "guiding moieties" to ensure targeted delivery to NETs...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38524128/neutrophils-isolated-from-systemic-lupus-erythematosus-patients-exhibit-a-distinct-functional-phenotype
#7
JOURNAL ARTICLE
Neelakshi R Jog, Catriona A Wagner, Teresa Aberle, Eliza F Chakravarty, Cristina Arriens, Joel M Guthridge, Judith A James
Neutrophil dysregulation, particularly of a low-density subset, is associated with systemic lupus erythematosus (SLE); however, the exact role of normal-density neutrophils in SLE remains unknown. This study compares activation and functional phenotypes of neutrophils from SLE patients and healthy controls to determine potential contributions to SLE pathogenesis. Surface activation markers and release of neutrophil extracellular traps (NETs), granule proteins, and cytokines/chemokines were measured in resting and stimulated neutrophils from SLE patients (n=19) and healthy controls (n=10)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38524125/distinct-functional-neutrophil-phenotypes-in-sepsis-patients-correlate-with-disease-severity
#8
JOURNAL ARTICLE
Qingliang Yang, Jordan C Langston, Roman Prosniak, Samantha Pettigrew, Huaqing Zhao, Edwin Perez, Hannah Edelmann, Nadia Mansoor, Carmen Merali, Salim Merali, Nathaniel Marchetti, Balabhaskar Prabhakarpandian, Mohammad F Kiani, Laurie E Kilpatrick
PURPOSE: Sepsis is a clinical syndrome defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a highly heterogeneous syndrome with distinct phenotypes that impact immune function and response to infection. To develop targeted therapeutics, immunophenotyping is needed to identify distinct functional phenotypes of immune cells. In this study, we utilized our Organ-on-Chip assay to categorize sepsis patients into distinct phenotypes using patient data, neutrophil functional analysis, and proteomics...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523684/targeting-neutrophil-extracellular-traps-in-gouty-arthritis-insights-into-pathogenesis-and-therapeutic-potential
#9
REVIEW
Cantao Li, Chenxi Wu, Fenfen Li, Wenjing Xu, Xiaoxi Zhang, Yan Huang, Daozong Xia
Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation due to the deposition of monosodium urate (MSU) crystals in the joints. The pathophysiological mechanisms of GA are not yet fully understood, and therefore, the identification of effective therapeutic targets is of paramount importance. Neutrophil extracellular traps (NETs), an intricate structure of DNA scaffold, encompassing myeloperoxidase, histones, and elastases - have gained significant attention as a prospective therapeutic target for gouty arthritis, due to their innate antimicrobial and immunomodulatory properties...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38523002/low-level-ambient-ozone-exposure-associated-with-neutrophil-extracellular-traps-and-pro-atherothrombotic-biomarkers-in-healthy-adults
#10
JOURNAL ARTICLE
Hongbing Xu, Xinghou He, Bin Zhang, Mengyao Li, Yutong Zhu, Tong Wang, Shengcong Liu, Mushui Shu, Ding Ding, Yu Wang, Qian Zhao, Jianping Li, Xiaoming Song, Wei Huang
BACKGROUND AND AIMS: Uncertainty of the causality determinations for ambient ozone (O3 ) on cardiovascular events is heightened by the limited understanding of the mechanisms involved in humans. We aimed to examine the pro-atherothrombotic impacts of O3 exposure and to explore the potential mediating roles of dysfunctional neutrophils, focusing on neutrophil extracellular traps (NETs). METHODS: A longitudinal panel study of 152 healthy adults was conducted in the cool to cold months with relatively low levels of O3 between September 2019 and January 2020 in Beijing, China...
March 7, 2024: Atherosclerosis
https://read.qxmd.com/read/38522826/nanoparticle-targeting-of-neutrophil-glycolysis-prevents-lung-ischemia-reperfusion-injury
#11
JOURNAL ARTICLE
Fuyi Liao, Davide Scozzi, Dequan Zhou, Mina Maksimos, Camila Diedrich, Marlene Cano, Laneshia K Tague, Zhyi Liu, Jeffrey A Haspel, Jennifer M Leonard, Wenjun Li, Alexander S Krupnick, Brian W Wong, Daniel Kreisel, Abdel Kareem Azab, Andrew E Gelman
Neutrophils exacerbate pulmonary ischemia-reperfusion injury (IRI) resulting in poor short and long-term outcomes for lung transplant recipients. Glycolysis powers neutrophil activation, but it remains unclear if neutrophil-specific targeting of this pathway will inhibit IRI. Lipid nanoparticles containing the glycolysis flux inhibitor 2-deoxyglucose (2-DG) were conjugated to neutrophil-specific Ly6G antibodies (NP-Ly6G(2-DG)). Intravenously administered NP-Ly6G(2-DG) to mice exhibited high specificity for circulating neutrophils...
March 22, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38522750/cholesterol-trafficking-to-the-er-leads-to-activation-of-camkii-jnk-nlrp3-and-promotes-atherosclerosis
#12
JOURNAL ARTICLE
Mustafa Yalcinkaya, Wenli Liu, Tong Xiao, Sandra Abramowicz, Ranran Wang, Nan Wang, Marit Westerterp, Alan R Tall
The deposition of cholesterol-rich lipoproteins in the arterial wall triggers macrophage inflammatory responses, which promote atherosclerosis. The NLRP3 inflammasome aggravates atherosclerosis; however, cellular mechanisms connecting macrophage cholesterol accumulation to inflammasome activation are poorly understood. We investigated the mechanisms of NLRP3 inflammasome activation in cholesterol loaded macrophages and in atherosclerosis-prone Ldlr-/- mice with defects in macrophage cholesterol efflux. We found that accumulation of cholesterol in macrophages treated with modified LDL or cholesterol crystals, or in macrophages defective in the cholesterol efflux promoting transporters ABCA1 and ABCG1, leads to activation of NLRP3 inflammasomes as a result of increased cholesterol trafficking from the plasma membrane to the ER, via Aster-B...
March 22, 2024: Journal of Lipid Research
https://read.qxmd.com/read/38520727/neutrophil-targeting-platform-reduces-neutrophil-extracellular-traps-for-improved-traumatic-brain-injury-and-stroke-theranostics
#13
JOURNAL ARTICLE
Qingchun Mu, Kai Yao, Madiha Zahra Syeda, Jinlong Wan, Qian Cheng, Zhen You, Rui Sun, Yufei Zhang, Huamiao Zhang, Yuting Lu, Zhicheng Luo, Yang Li, Fuyao Liu, Huiping Liu, Xinyu Zou, Yanfen Zhu, Kesong Peng, Chunming Huang, Xiaoyuan Chen, Longguang Tang
Traumatic brain injuries (TBI) and stroke are major causes of morbidity and mortality in both developing and developed countries. The complex and heterogeneous pathophysiology of TBI and cerebral ischemia-reperfusion injury (CIRI), in addition to the blood-brain barrier (BBB) resistance, is a major barrier to the advancement of diagnostics and therapeutics. Clinical data showed that the severity of TBI and stroke is positively correlated with the number of neutrophils in peripheral blood and brain injury sites...
March 23, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38519881/vascular-smooth-muscle-cells-in-response-to-cholesterol-crystals-modulates-inflammatory-cytokines-release-and-promotes-neutrophil-extracellular-trap-formation
#14
JOURNAL ARTICLE
Jishamol Thazhathveettil, Ashok Kumar Kumawat, Isak Demirel, Allan Sirsjö, Geena Varghese Paramel
BACKGROUND: The formation and accumulation of cholesterol crystals (CC) at the lesion site is a hallmark of atherosclerosis. Although studies have shown the importance of vascular smooth muscle cells (VSMCs) in the disease atherosclerosis, little is known about the molecular mechanism behind the uptake of CC in VSMCs and their role in modulating immune response. METHODS: Human aortic smooth muscle cells were cultured and treated with CC. CC uptake and CC mediated signaling pathway and protein induction were studied using flow cytometry, confocal microscopy, western blot and Olink proteomics...
March 22, 2024: Molecular Medicine
https://read.qxmd.com/read/38519636/machine-learning-framework-develops-neutrophil-extracellular-traps-model-for-clinical-outcome-and-immunotherapy-response-in-lung-adenocarcinoma
#15
JOURNAL ARTICLE
A Xuan Han, B Yaping Long, C Yao Li, D Di Huang, E Qi Xiong, F Jinfeng Li, G Liangliang Wu, Qiaowei Liu, G Bo Yang, H Yi Hu
Neutrophil extracellular traps (NETs) are novel inflammatory cell death in neutrophils. Emerging studies demonstrated NETs contributed to cancer progression and metastases in multiple ways. This study intends to provide a prognostic NETs signature and therapeutic target for lung adenocarcinoma (LUAD) patients. Consensus cluster analysis performed by 38 reported NET-related genes in TCGA-LUAD cohorts. Then, WGCNA network was conducted to investigate characteristics genes in clusters. Seven machine learning algorithms were assessed for training of the model, the optimal model was picked by C-index and 1-, 3-, 5-year ROC value...
March 22, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38518099/correction-to-neutrophil-extracellular-traps-nets-and-th-2-dominant-immune-responses-in-chronic-granulomatous-chromoblastomycosis
#16
(no author information available yet)
No abstract text is available yet for this article.
March 7, 2024: Medical Mycology
https://read.qxmd.com/read/38518057/a-machine-learning-based-diagnostic-model-for-myocardial-infarction-patients-analysis-of-neutrophil-extracellular-traps-related-genes-and-eqtl-mendelian-randomization
#17
JOURNAL ARTICLE
Meng Sheng, Xueying Cui
To identify neutrophil extracellular trap (NET)-associated gene features in the blood of patients with myocardial infarction (MI) using bioinformatics and machine learning, with the aim of exploring potential diagnostic utility in atherosclerosis. The datasets GSE66360 and GSE48060 were downloaded from the Gene Expression Omnibus (GEO) public database. GSE66360 was used as the training set, and GSE48060 was used as an independent validation set. Differential genes related to NETs were screened using R software...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517050/neutrophil-extracellular-traps-induce-pyroptosis-of-pulmonary-microvascular-endothelial-cells-by-activating-the-nlrp3-inflammasome
#18
JOURNAL ARTICLE
Peipei Zhao, Jiarui Zhu, Ling Bai, Wenlan Ma, Feifei Li, Cen Zhang, Liangtao Zhao, Liuyang Wang, Sigong Zhang
Excessive formation of neutrophil extracellular traps (NETs) may lead to myositis-related interstitial lung disease (ILD). There is evidence that NETs can directly injure vascular endothelial cells and play a pathogenic role in the inflammatory exudation of ILD. However, the specific mechanism is unclear. This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro...
March 22, 2024: Clinical and Experimental Immunology
https://read.qxmd.com/read/38515758/group-a-streptococcal-collagen-like-protein-1-restricts-tumor-growth-in-murine-pancreatic-adenocarcinoma-and-inhibits-cancer-promoting-neutrophil-extracellular-traps
#19
JOURNAL ARTICLE
Emily A Henderson, Abby Ivey, Soo Jeon Choi, Stell Santiago, Dudley McNitt, Tracy W Liu, Slawomir Lukomski, Brian A Boone
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer associated with an immunosuppressive environment. Neutrophil extracellular traps (NETs) were initially described in the context of infection but have more recently been implicated in contributing to the tolerogenic immune response in PDAC. Thus, NETs are an attractive target for new therapeutic strategies. Group A Streptococcus (GAS) has developed defensive strategies to inhibit NETs. METHODS: In the present work, we propose utilizing intra-tumoral GAS injection to stimulate anti-tumor activity by inhibiting cancer-promoting NETs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38515356/immune-cell-mediated-autoimmune-responses-in-severe-asthma
#20
REVIEW
Thi Bich Tra Cao, Quang Luu Quoc, Jae-Hyuk Jang, Hae-Sim Park
Severe asthma (SA) has heterogeneous inflammatory phenotypes characterized by persistent airway inflammation (eosinophilic and/or neutrophilic inflammation) and remodeling. Various immune cells (eosinophils, neutrophils, and macrophages) become more activated and release inflammatory mediators and extracellular traps, damaging the protective barrier of airway epithelial cells and further activating other immune and structural cells. These cells play a role in autoimmune responses in asthmatic airways, where the adaptive immune system generates autoantibodies, inducing immunoglobulin G-dependent airway inflammation...
April 2024: Yonsei Medical Journal
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