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https://www.readbyqxmd.com/read/28606220/current-and-future-strategies-for-the-nutritional-management-of-cardiometabolic-complications-of-androgen-deprivation-therapy-for-prostate-cancer
#1
Lauren Turner, Karen Poole, Sara Faithfull, Bruce A Griffin
Androgen deprivation therapy (ADT) is used widely as part of a combined modality for the treatment of prostate cancer. However, ADT has also been associated with the development of cardiometabolic complications that can increase mortality from cardiovascular events. There is emerging evidence to suggest that ADT-related cardiometabolic risk can be mitigated by diet and lifestyle modification. While the clinical focus for a nutritional approach for achieving this effect is unclear, it may depend upon the timely assessment and targeting of dietary changes to the specific risk phenotype of the patient...
June 13, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28596013/two-likely-targets-for-the-anti-cancer-effect-of-indole-derivatives-from-cruciferous-vegetables-pi3k-akt-mtor-signalling-pathway-and-the-aryl-hydrocarbon-receptor
#2
REVIEW
Ada Popolo, Aldo Pinto, Maria Daglia, Seyed Fazel Nabavi, Ammad Ahmad Farooqi, Luca Rastrelli
Diets containing high quantities of plant foods are linked with a decreased likelihood of incidence of cancer. Several common plant-based dietary components exert effects on DNA methylation levels, and can positively influence genome stability and the transcription of tumor suppressors and oncogenes. Indole-3-carbinol (I3C) is a substance present in vegetables of the Brassicaeae family, especially broccoli, white cabbage, Brussels sprouts and cauliflower. The in vivo biological effects of I3C are ascribed to a series of oligomeric products (including 3,3'-diindolylmethane), developed under acidic conditions...
June 5, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28584617/tumor-cells-growth-and-survival-time-with-the-ketogenic-diet-in-animal-models-a-systematic-review
#3
REVIEW
Soheila Khodadadi, Nafiseh Sobhani, Somaye Mirshekar, Reza Ghiasvand, Makan Pourmasoumi, Maryam Miraghajani, Somayeh Shahraki Dehsoukhteh
Recently, interest in targeted cancer therapies via metabolic pathways has been renewed with the discovery that many tumors become dependent on glucose uptake during anaerobic glycolysis. Also the inability of ketone bodies metabolization due to various deficiencies in mitochondrial enzymes is the major metabolic changes discovered in malignant cells. Therefore, administration of a ketogenic diet (KD) which is based on high in fat and low in carbohydrates might inhibit tumor growth and provide a rationale for therapeutic strategies...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28510291/associations-between-rna-splicing-regulatory-variants-of-stemness-related-genes-and-racial-disparities-in-susceptibility-to-prostate-cancer
#4
Yanru Wang, Jennifer A Freedman, Hongliang Liu, Patricia G Moorman, Terry Hyslop, Daniel J George, Norman H Lee, Steven R Patierno, Qingyi Wei
Evidence suggests that cells with a stemness phenotype play a pivotal role in oncogenesis, and prostate cells exhibiting this phenotype have been identified. We used two genome-wide association study (GWAS) datasets of African descendants, from the Multiethnic/Minority Cohort Study of Diet and Cancer (MEC) and the Ghana Prostate Study, and two GWAS datasets of non-Hispanic whites, from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Breast and Prostate Cancer Cohort Consortium (BPC3), to analyze the associations between genetic variants of stemness-related genes and racial disparities in susceptibility to prostate cancer...
May 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28507039/do-aspirin-and-other-nsaids-confer-a-survival-benefit-in-men-diagnosed-with-prostate-cancer-a-pooled-analysis-of-nih-aarp-and-plco-cohorts
#5
Cindy Ke Zhou, Sarah E Daugherty, Linda M Liao, Neal D Freedman, Christian C Abnet, Ruth Pfeiffer, Michael B Cook
Prostate cancer is one of the leading causes of cancer-related death in U.S. men. There is an unmet need to identify modifiable risk factors for prostate cancer survival. Experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may improve prostate cancer survival through antithrombotic and anti-inflammation mechanisms. Results from previous observational studies have been equivocal, and few have assessed whether an etiologically relevant time window of exposure exists. We sampled incident prostate cancer cases from two large U...
May 15, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28489892/exposure-to-maternal-obesogenic-diet-worsens-some-but-not-all-pre-cancer-phenotypes-in-a-murine-genetic-model-of-prostate-cancer
#6
Theresa Okeyo-Owuor, Emily Benesh, Scott Bibbey, Michaela Reid, Jacques Halabi, Siobhan Sutcliffe, Kelle Moley
Prostate cancer research has been predominantly focused on adult exposures and risk factors. However, because the prostate develops during gestation and early life, exposure to external factors, such as obesity, during development could affect the prostate cancer progression in adults. Our previous work demonstrated that exposure to a high fat/high sugar (HF/HS) diet during gestation and until weaning stimulated prostate hyperplasia and altered the Pten/Akt pathway in adult mice fed a normal diet after weaning...
2017: PloS One
https://www.readbyqxmd.com/read/28456709/a-laparoscopic-approach-is-associated-with-a-decreased-incidence-of-ssi-in-patients-undergoing-palliative-surgery-for-malignant-bowel-obstruction
#7
Yoshiaki Maeda, Toshiki Shinohara, Tomonari Katayama, Nozomi Minagawa, Masao Sunahara, Akihisa Nagatsu, Noriaki Futakawa, Tomonori Hamada
BACKGROUND: Several authors have reported on the utility of a laparoscopic approach for the palliation of malignant bowel obstruction (MBO); however, the advantages of laparoscopic surgery for MBO have not yet been confirmed. METHODS: We retrospectively reviewed the medical records of patients who underwent palliative surgery for MBO between 2007 and 2015. Laparoscopic procedures have been performed when technically possible since 2014. Successful palliation was defined as the ability to tolerate solid food (TSF) for at least 2 weeks...
June 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28446545/a-pooled-analysis-of-15-prospective-cohort-studies-on-the-association-between-fruit-vegetable-and-mature-bean-consumption-and-risk-of-prostate-cancer
#8
Joshua Petimar, Kathryn M Wilson, Kana Wu, Molin Wang, Demetrius Albanes, Piet A van den Brandt, Michael B Cook, Graham G Giles, Edward L Giovannucci, Gary G Goodman, Phyllis J Goodman, Niclas Håkansson, Kathy Helzlsouer, Timothy J Key, Laurence N Kolonel, Linda M Liao, Satu Männistö, Marjorie L McCullough, Roger L Milne, Marian L Neuhouser, Yikyung Park, Elizabeth A Platz, Elio Riboli, Norie Sawada, Jeannette M Schenk, Shoichiro Tsugane, Bas Verhage, Ying Wang, Lynne R Wilkens, Alicja Wolk, Regina G Ziegler, Stephanie A Smith-Warner
BACKGROUND: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear. METHODS: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52,680 total cases and 3,205 prostate cancer deaths among 842,149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28437029/men-s-eating-and-living-meal-study-calgb-70807-alliance-recruitment-feasibility-and-baseline-demographics-of-a-randomized-trial-of-diet-in-men-on-active-surveillance-for-prostate-cancer
#9
J Kellogg Parsons, John P Pierce, James Mohler, Electra Paskett, Sin-Ho Jung, Michael J Morris, Eric Small, Olwen Hahn, Peter Humphrey, John Taylor, James Marshall
OBJECTIVE: To assess the feasibility of performing national, randomized trials of dietary interventions for localized prostate cancer. METHODS: The Men's Eating and Living (MEAL) study (CALGB 70807 [Alliance]) is a phase III clinical trial testing the efficacy of a high-vegetable diet to prevent progression in patients with prostate cancer on active surveillance (AS). Participants were randomized to a validated diet counselling intervention or to a control condition...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28423628/benzyl-isothiocyanate-induces-reactive-oxygen-species-initiated-autophagy-and-apoptosis-in-human-prostate-cancer-cells
#10
Ji-Fan Lin, Te-Fu Tsai, Shan-Che Yang, Yi-Chia Lin, Hung-En Chen, Kuang-Yu Chou, Thomas I-Sheng Hwang
Benzyl isothiocyanate (BITC) in cruciferous plants, which are part of the human diet, has been shown to induce apoptosis in various types of cancer. In this study, we show that BITC effectively suppresses the growth of cultured human prostate cancer cells (CRW-22Rv1 and PC3) by causing mitochondrial membrane potential loss, caspase 3/7 activation and DNA fragmentation. Furthermore, BITC induces ROS generation in these cells. The induction of apoptosis by BITC was significantly attenuated in the presence of N-acetylcysteine (NAC) and catalase (CAT), well-studied ROS scavengers...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422034/endocrine-disruptors-and-prostate-cancer
#11
Eduardo Sánchez de Badajoz, José Maria Lage-Sánchez, Pilar Sánchez-Gallegos
OBJECTIVES: Although prostate cancer is probably the most frequent cancer in men, little is known about its etiology. Clear evidence exists about variations in the incidence of prostate cancer between populations living in different countries. These variations could be explained by differences in lifestyle and a possible association with a set of substances that are able to intervene in the origin of the disease. METHODS: The reason that lifestyle may be the cause of prostate cancer is related to endocrine disruptors...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28410994/the-role-of-oxysterols-in-human-cancer
#12
REVIEW
Alzbeta Kloudova, F Peter Guengerich, Pavel Soucek
Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the role of oxysterols is also important in pathological conditions (e...
July 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28410117/racial-disparities-disruptive-genes-in-prostate-carcinogenesis
#13
REVIEW
Savita Singh, Alexis Plaga, Girish C Shukla
Population specific studies in prostate cancer (PCa) reveal a unique heterogeneous etiology. Various factors, such as genetics, environment and dietary regimen seems to determine disease progression, therapeutic resistance and rate of mortality. Enormous disparity documented in disease incidences, aggressiveness and mortality in PCa among AAs (African Americans) and CAs (Caucasian Americans) is attributed to the variations in genetics, epigenetics and their association with metabolism. Scientific and clinical evidences have revealed the influence of variations in Androgen Receptor (AR), RNAse L, macrophage scavenger receptor 1 (MRS1), androgen metabolism by cytochrome P450 3A4, differential regulation of microRNAs, epigenetic alterations and diet in racial disparity in PCa incidences and mortality...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28408935/socioeconomic-and-racial-ethnic-disparities-in-cancer-mortality-incidence-and-survival-in-the-united-states-1950-2014-over-six-decades-of-changing-patterns-and-widening-inequalities
#14
Gopal K Singh, Ahmedin Jemal
We analyzed socioeconomic and racial/ethnic disparities in US mortality, incidence, and survival rates from all-cancers combined and major cancers from 1950 to 2014. Census-based deprivation indices were linked to national mortality and cancer data for area-based socioeconomic patterns in mortality, incidence, and survival. The National Longitudinal Mortality Study was used to analyze individual-level socioeconomic and racial/ethnic patterns in mortality. Rates, risk-ratios, least squares, log-linear, and Cox regression were used to examine trends and differentials...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28385910/metformin-reduces-prostate-tumor-growth-in-a-diet-dependent-manner-by-modulating-multiple-signaling-pathways
#15
Andre Sarmento-Cabral, Fernando L-Lopez, Manuel D Gahete, Justo P Castano, Raul M Luque
Prostate-cancer is strongly influenced by obesity, wherein metformin could represent a promising treatment; however, the endocrine-metabolic/cellular/molecular-mechanisms underlying these associations and effects are still unclear. To determine the beneficial anti-tumoral effects of metformin on prostate-cancer progression/aggressiveness and the relative contribution of high-fat diet (HFD; independently of obesity), we used HFD-fed immuno-suppressed mice inoculated with PC3 cells (which exhibited partial resistance to diet-induced obesity) compared with low-fat diet (LFD)-fed control-mice...
April 6, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28378849/prediagnostic-enterolactone-concentrations-and-mortality-among-danish-men-diagnosed-with-prostate-cancer
#16
A K Eriksen, C Kyrø, N Nørskov, A K Bolvig, J Christensen, A Tjønneland, K Overvad, R Landberg, A Olsen
BACKGROUND/OBJECTIVES: Evidence on the role of diet in relation to prostate cancer progression is sparse. Foods rich in lignans have shown beneficial effects on prostate cancer progression in both animal studies and small human intervention studies, including beneficial effects on prostate-specific antigen levels and tumour growth. The lignan metabolite, enterolactone, has further shown to slow prostate cancer cell growth in vitro. The aim was to investigate the association between prediagnostic enterolactone concentrations and mortality among men with prostate cancer...
April 5, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28362175/synergistic-impact-of-d-%C3%AE-tocotrienol-and-geranylgeraniol-on-the-growth-and-hmg-coa-reductase-of-human-du145-prostate-carcinoma-cells
#17
Hoda Yeganehjoo, Russell DeBose-Boyd, Brian K McFarlin, Huanbiao Mo
The growth-suppressive effect of d-δ-tocotrienol and geranylgeraniol is at least partially attributed to their impact on 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth-related proteins including RAS. We hypothesize that these agents synergistically impact cell growth based on their complementary mechanisms of action with HMG CoA reductase. d-δ-tocotrienol (0-40 µmol/L; half maximal inhibitory concentration [IC50] = 15 µmol/L) and geranylgeraniol (0-100 µmol/L; IC50 = 60 µmol/L) each induced concentration-dependent suppression of the growth of human DU145 prostate carcinoma cells...
May 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28359098/attenuation-of-resting-but-not-load-mediated-protein-synthesis-in-prostate-cancer-patients-on-androgen-deprivation
#18
Erik D Hanson, André R Nelson, Daniel W D West, John A Violet, Lannie O'Keefe, Stuart M Phillips, Alan Hayes
Context: Androgen deprivation therapy (ADT) is a common prostate cancer (PCa) treatment but results in muscular atrophy. Periodic increases in muscle protein synthesis (MPS) that occur after resistance exercise or protein intake may ameliorate this muscle loss, but the impact of these anabolic stimuli during ADT is unclear. Objective: To determine the acute MPS response to whey protein supplementation with and without resistance exercise during ADT. Design: Acute response in PCa patients vs age-matched controls (CON)...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28352127/insights-from-engraftable-immunodeficient-mouse-models-of-hyperinsulinaemia
#19
Michelle L Maugham, Patrick B Thomas, Gabrielle J Crisp, Lisa K Philp, Esha T Shah, Adrian C Herington, Chen Chen, Laura S Gregory, Colleen C Nelson, Inge Seim, Penny L Jeffery, Lisa K Chopin
Hyperinsulinaemia, obesity and dyslipidaemia are independent and collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 (-/-)) suitable for engraftment with human-derived tissue xenografts, and the effect of diet-induced hyperinsulinaemia on human prostate cancer cell line xenograft growth, were investigated. Rag1 (-/-)and NOD/SCID HFD-fed mice demonstrated diet-induced impairments in glucose tolerance at 16 and 23 weeks post weaning...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28351315/obesity-associated-digestive-cancers-a-review-of-mechanisms-and-interventions
#20
REVIEW
Jiachen Zheng, Ming Zhao, Jiahui Li, Guoying Lou, Yanyan Yuan, Shizhong Bu, Yang Xi
The prevalence of obesity has steadily increased over the past few decades. Previous studies suggest that obesity is an oncogenic factor and that over 20% of all cancers are obesity-related. Among such cancers, digestive system malignancies (including esophageal adenocarcinomas, colorectal cancers, and cancers of the gastric cardia, liver, and pancreas) are reported most frequently. While the 5-year survival rates of cancers of the breast and prostate are 90%, that rate is only 45% for digestive cancers. In this review, the mechanisms of obesity-associated digestive cancers are discussed, with an emphasis on obesity-related gene mutations, insulin and insulin-like growth factor signaling pathways, chronic inflammation, and altered adipokine levels...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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