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https://www.readbyqxmd.com/read/29776955/high-fat-diet-induced-inflammation-accelerates-prostate-cancer-growth-via-il6-signaling
#1
Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Maria Del Carmen Rodriguez Pena, Jennifer B Gordetsky, Eiichi Morii, Kazutake Tsujikawa, George J Netto, Norio Nonomura
OBJECTIVE: High-fat diet (HFD) could induce prostate cancer progression. The aim of this study is to identify mechanisms of HFD-induced prostate cancer progression, focusing on inflammation. MATERIALS AND METHODS: We administered HFD and celecoxib to autochthonous immunocompetent Pb-Cre+; Pten(fl/fl) model mice for prostate cancer. Tumor growth was evaluated by tumor weight and Ki67 stain, and local immune cells were assessed by flow cytometry at 22 weeks of age...
May 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29765146/do-dietary-calcium-and-vitamin-d-matter-in-men-with-prostate-cancer
#2
REVIEW
Thierry Capiod, Nicolas Barry Delongchamps, Natascha Pigat, Jean-Claude Souberbielle, Vincent Goffin
Active surveillance (AS) is an attractive alternative to immediate treatment for men with low-risk prostate cancer. Thus, the identification of environmental factors that promote the progression of indolent disease towards aggressive stages is critical to optimize clinical management. Epidemiological studies suggest that calcium-rich diets contribute to an increased risk of developing prostate cancer and that vitamin D reduces this risk. However, the potential effect of these nutrients on the progression of early-stage prostate tumours is uncertain, as studies in this setting are scarce and have not provided unambiguous conclusions...
May 15, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29762647/maternal-low-protein-diet-impairs-prostate-growth-in-young-rat-offspring-and-induces-prostate-carcinogenesis-with-aging
#3
Sergio A A Santos, Ana C Camargo, Flávia B Constantino, Ketlin T Colombelli, Fernanda Mani, Jaqueline C Rinaldi, Suelen Franco, Luiz M F Portela, Bruno O S Duran, Wellerson R Scarano, Barry T Hinton, Sergio L Felisbino, Luis A Justulin
Carcinogenesis is frequently linked to genetic background, however, exposure to environmental risk factors has gained attention as the etiologic agent for several types of cancer, including prostate. The intrauterine microenvironment has been described as a preponderant factor for offspring health; and maternal exposure to insult has been linked to chronic disease in older offspring. Using a model of maternal exposure to low protein diet (LPD; 6% protein), we demonstrated that impairment of offspring rat prostatic growth on postnatal day (PND) 21 was associated with prostate carcinogenesis in older offspring (PND 540)...
May 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29752709/association-between-a-pro-plant-based-dietary-score-and-cancer-risk-in-the-prospective-nutrinet-sant%C3%A3-cohort
#4
Abou Kane-Diallo, Bernard Srour, Laury Sellem, Mélanie Deschasaux, Paule Latino-Martel, Serge Hercberg, Pilar Galan, Philippine Fassier, Françoise Guéraud, Fabrice H Pierre, Emmanuelle Kesse-Guyot, Benjamin Allès, Mathilde Touvier
Diverse plant products (e.g. fruits, vegetables, legumes) are associated with decreased cancer risk at several locations while red and processed meat were found to increase cancer risk. A pro plant-based dietary score reflecting the relative contribution of consumed plant vs animal products was developed, and was associated with lower overall mortality, type 2 diabetes and cardiovascular disease risk, among omnivorous adults. For the first time, we investigated the prospective associations between this pro plant-based dietary score and cancer risk...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29740894/epidemiology-of-prostate-cancer-in-asian-countries
#5
REVIEW
Takahiro Kimura, Shin Egawa
The incidence of prostate cancer has been increasing worldwide in recent years. The GLOBOCAN project showed that prostate cancer was the second most frequently diagnosed cancer and the fifth leading cause of cancer mortality among men worldwide in 2012. This trend has been growing even in Asian countries, where the incidence had previously been low. However, the accuracy of data about incidence and mortality as a result of prostate cancer in some Asian countries is limited. The cause of this increasing trend is multifactorial...
May 8, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29722851/calcium-magnesium-and-whole-milk-intakes-and-high-aggressive-prostate-cancer-in-the-north-carolina-louisiana-prostate-cancer-project-pcap
#6
Susan E Steck, Omonefe O Omofuma, L Joseph Su, Amanda A Maise, Anna Woloszynska-Read, Candace S Johnson, Hongmei Zhang, Jeannette T Bensen, Elizabeth T H Fontham, James L Mohler, Lenore Arab
Background: Calcium and dairy product intakes have been positively associated with prostate cancer risk. An imbalance in concentrations of calcium and magnesium has been associated with multiple chronic diseases, although few studies have examined the relation with prostate cancer aggressiveness. Objective: The goal of this study was to examine the association between dietary intakes of calcium and magnesium, the calcium-to-magnesium ratio (Ca:Mg), and dairy products and prostate cancer aggressiveness...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29719480/nuclear-medicine-in-prostate-cancer-a-new-era-for-radiotracers
#7
REVIEW
Vincenzo Cuccurullo, Giuseppe Danilo Di Stasio, Luigi Mansi
Natural history of prostate cancer (PCa) is extremely variable, as it ranges from indolent and slow growing tumors to highly aggressive histotypes. Genetic background and environmental factors co-operate to the genesis and clinical manifestation of the tumor and include among the others race, family, specific gene variants (i.e., BRCA1 and BRCA2 mutations), acute and chronic inflammation, infections, diet and drugs. In this scenario, remaining actual the clinical interest of bone scan (BS) in detecting skeletal metastases, an important role in diagnostic imaging may be also carried out by, positron emission tomography/computed tomography (PET/CT) and PET/magnetic resonance imaging (PET/MRI), which combine morphological information provided by CT and MRI with functional and metabolic data provided by PET acquisitions...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29708021/association-between-erectile-dysfunction-and-subsequent-prostate-cancer-development-a-population-based-cohort-study-with-double-concurrent-comparison-groups
#8
Victor C Kok, Yi-Hsuan Hsiao, Jorng-Tzong Horng, Kung-Liang Wang
Recent studies indicate that erectile dysfunction (ED) and prostate cancer share common potential risk factors such as chronic inflammation, prostatitis, cigarette smoking, obesity, a high animal fat diet, sedentarism, and depression. There is great interest in knowing if ED is associated with prostate cancer. This study aimed to investigate if men afflicted with ED harbor an increased risk of prostate cancer, utilizing two concurrent comparison groups, constructed from the Taiwan NHIRD, with up to 8 years' follow-up...
April 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29697282/the-role-of-genetic-variants-in-the-association-between-dietary-acrylamide-and-advanced-prostate-cancer-in-the-netherlands-cohort-study-on-diet-and-cancer
#9
Andy Perloy, Leo J Schouten, Piet A van den Brandt, Roger Godschalk, Frederik-Jan van Schooten, Janneke G F Hogervorst
To investigate the association between dietary acrylanide and advanced prostate cancer, we examined acrylamide-gene interactions for advanced prostate cancer risk by using data from the Netherlands Cohort Study. Participants (n = 58,279 men) completed a baseline food frequency questionnaire (FFQ), from which daily acrylamide intake was calculated. At baseline, 2,411 men were randomly selected from the full cohort for case-cohort analysis. Fifty eight selected single nucleotide polymorphisms (SNPs) and two gene deletions in genes in acrylamide metabolism, DNA repair, sex steroid systems, and oxidative stress were analyzed...
April 26, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29696211/characteristics-of-cancer-patients-participating-in-presurgical-lifestyle-intervention-trials-exploring-effects-on-tumor-biology
#10
John A Dasher, Andrew D Frugé, Denise C Snyder, Wendy Demark-Wahnefried
Background: Poor diet and insufficient physical activity are strongly associated with an increased risk of several cancers. Preclinical studies suggest that lifestyle modifications may exert favorable effects on tumor biology. Randomized controlled trials in the presurgical setting serve as an ideal means to translate this research to humans; however, little is known about the characteristics of patients who enroll in these presurgical trials versus those who do not. Methods: Screening databases from three presurgical lifestyle intervention trials for breast and prostate cancer patients conducted at Duke University Medical Center (NCT00049309) and the University of Alabama at Birmingham (NCT02224807 and NCT01886677) were combined for analysis...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29695238/mass-media-and-risk-factors-for-cancer-the-under-representation-of-age
#11
Sara Macdonald, Yvonne Cunningham, Chris Patterson, Katie Robb, Una Macleod, Thomas Anker, Shona Hilton
BACKGROUND: Increasing age is a risk factor for developing cancer. Yet, older people commonly underestimate this risk, are less likely to be aware of the early symptoms, and are more likely to be diagnosed with advanced stage cancer. Mass media are a key influence on the public's understanding health issues, including cancer risk. This study investigates how news media have represented age and other risk factors in the most common cancers over time. METHODS: Eight hundred articles about the four most common cancers (breast, prostate, lung and colorectal) published within eight UK national newspapers in 2003, 2004, 2013 and 2014 were identified using the Nexis database...
April 26, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29684136/effects-of-a-group-mediated-exercise-and-dietary-intervention-in-the-treatment-of-prostate-cancer-patients-undergoing-androgen-deprivation-therapy-results-from-the-idea-p-trial
#12
Brian C Focht, Alexander R Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M Fairman, Jennifer M Thomas-Ahner, Jackie Buell, J Paul Monk, Amir Mortazavi, Steven K Clinton
Background: Although androgen-deprivation therapy (ADT) is the foundation of treatment for prostate cancer, the physiological impacts of ADT result in functional decline and enhanced risk of chronic disease and metabolic syndrome. Purpose: The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) is a single-blind, randomized, pilot trial comparing the effects of a group-mediated, cognitive-behavioral (GMCB) exercise and dietary intervention (EX+D) with those of a standard-of-care (SC) control during the treatment of prostate cancer patients undergoing ADT...
April 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29674390/consumption-of-sugars-sugary-foods-and-sugary-beverages-in-relation-to-adiposity-related-cancer-risk-in-the-framingham-offspring-cohort-1991-2013
#13
Nour Makarem, Elisa V Bandera, Yong Lin, Paul Jacques, Richard B Hayes, Niyati Parekh
BACKGROUND: Higher sugar consumption may increase cancer risk by promoting insulin-glucose dysregulation, oxidative stress, hormonal imbalances, and excess adiposity. This prospective study investigates the association between dietary sugars(fructose and sucrose) and sugary foods and beverages in relation to combined and site-specific (breast, prostate, colorectal) adiposity-associated cancers. METHODS: The analytic sample consisted of 3,184 adults, aged 26-84y, from the Framingham Offspring cohort...
April 19, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29671180/dietary-patterns-and-prostate-cancer-risk-in-japanese-the-japan-public-health-center-based-prospective-study-jphc-study
#14
Sangah Shin, Eiko Saito, Norie Sawada, Junko Ishihara, Ribeka Takachi, Akiko Nanri, Taichi Shimazu, Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
PURPOSE: The development of prostate cancer may be impacted by environmental factors, including diet. The aim of this study was to evaluate the association between dietary patterns and risk of prostate cancer in a large prospective cohort study among Japanese men. METHODS: A total of 43,469 men who participated in the Japan Public Health Center-based Prospective Study were followed from 1995 to 1998 to the end of 2012, during which 1,156 cases of prostate cancer were newly identified...
April 18, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29651647/an-estrogen-related-lifestyle-score-is-associated-with-risk-of-postmenopausal-breast-cancer-in-the-plco-cohort
#15
Mark A Guinter, Alexander C McLain, Anwar T Merchant, Dale P Sandler, Susan E Steck
PURPOSE: Healthy or unhealthy lifestyle behaviors are often adopted together. We aimed to investigate the combined effect of estrogen-related lifestyle factors on postmenopausal breast cancer risk. METHODS: Data from 27,153 women enrolled in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were used. We created an estrogen-related lifestyle score (ERLS) by incorporating a previously developed measure of estrogenic diet, alcohol intake, body mass index (BMI), and physical activity...
April 12, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29650325/improving-the-genetic-signature-of-prostate-cancer-the-somatic-mutations
#16
Luis Javier Martinez-Gonzalez, Manrique Pascual Geler, Inmaculada Robles Fernandez, Jose Manuel Cozar, Jose Antonio Lorente, Maria Jesus Alvarez Cubero
BACKGROUND: Somatic mutations have been related to the highest incidence of metastatic disease and different treatment responses. The molecular cause of prostate cancer (PC) is still unclear; however, its progression involves alterations in oncogenes and tumor suppressor genes as well as somatic mutations such as the ones in PIK3CA gene. A high percentage of PC is considered sporadic, which means that the damage to the genes occurs by chance after birth (mainly somatic mutations will drive the cancer event)...
April 9, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29645327/exploring-cancer-survivors-views-of-health-behavior-change-where-do-you-start-where-do-you-stop-with-everything
#17
Teresa Corbett, Tara Cheetham, Andre Matthias Müller, Joanna Slodkowska-Barabasz, Laura Wilde, Adele Krusche, Alison Richardson, Claire Foster, Eila Watson, Paul Little, Lucy Yardley, Katherine Bradbury
OBJECTIVE: Physical activity (PA) and a healthy diet can improve the well-being of cancer survivors. However, cancer survivors often do not engage in these behaviours. This study aimed to explore barriers and facilitators to engaging in these behaviours following cancer treatment. METHODS: During the development of a web-based intervention to enhance health-related quality of life in cancer survivors, 32 people who had completed treatment for breast, colon or prostate cancer were presented with an intervention for PA and healthy eating...
April 12, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29574860/a-dietary-pattern-based-on-estrogen-metabolism-is-associated-with-breast-cancer-risk-in-a-prospective-cohort-of-postmenopausal-women
#18
Mark A Guinter, Alexander C McLain, Anwar T Merchant, Dale P Sandler, Susan E Steck
Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxylated estrogen metabolites in a subsample of Prostate, Lung, Colorectal and Ovarian Screening Trial (PLCO) participants (n = 653) using reduced rank regression, and examined its association with postmenopausal breast cancer prospectively in the larger PLCO cohort (n = 27,488)...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29549214/does-a-prostate-cancer-diagnosis-affect-management-of-pre-existing-diabetes-results-from-pcbase-sweden-a-nationwide-cohort-study
#19
Danielle Crawley, Hans Garmo, Sarah Rudman, Pär Stattin, Björn Zethelius, Jo Armes, Lars Holmberg, Jan Adolfsson, Mieke Van Hemelrijck
OBJECTIVES: Both prostate cancer (PCa) and type 2 diabetes mellitus (T2DM) are increasingly prevalent conditions, which frequently coexist in men. Here, we set out to specifically examine the impact of a PCa diagnosis and its treatment on T2DM treatment. SETTING: This study uses observational data from Prostate Cancer database Sweden Traject. PARTICIPANTS: The study was undertaken in a cohort of 16 778 men with T2DM, of whom 962 were diagnosed with PCa during mean follow-up of 2...
March 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29542389/adherence-to-mediterranean-diet-and-risk-of-prostate-cancer
#20
Noelia Urquiza-Salvat, Manrique Pascual-Geler, Olga Lopez-Guarnido, Lourdes Rodrigo, Alba Martinez-Burgos, Jose Manuel Cozar, Francisco Manuel Ocaña-Peinado, Maria Jesus Álvarez-Cubero, Ana Rivas
In Europe, countries following the traditional Mediterranean Diet (MeDi), particularly Southern European countries, have lower prostate cancer (PCa) incidence and mortality compared to other European regions. In the present study, we investigated the association between the MeDi and the relative risk of PCa and tumor aggressiveness in a Spanish population. Among individual score components, it has been found that subjects with PCa were less likely to consume olive oil as the main culinary fat, vegetables, fruits and fish than those without...
March 15, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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