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Mood disorders inflammation

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https://www.readbyqxmd.com/read/28107669/medical-comorbidity-in-bipolar-disorder-the-link-with-metabolic-inflammatory-systems
#1
REVIEW
Ana SayuriYamagata, Elisa Brietzke, Joshua D Rosenblat, Ron Kakar, Roger S McIntyre
BACKGROUND: Bipolar disorder (BD) is associated with chronic low-grade inflammation, several medical comorbidities and a decreased life expectancy. Metabolic-inflammatory changes have been postulated as one of the main links between BD and medical comorbidity, although there are few studies exploring possible mechanisms underlying this relationship. Therefore, the aims of the current narrative review were 1) synthesize the evidence for metabolic-inflammatory changes that may facilitate the link between medical comorbidity and BD and 2) discuss therapeutic and preventive implications of these pathways...
January 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28105985/impact-of-traumatic-brain-injury-on-dopaminergic-transmission
#2
Yuan-Hao Chen, Eagle Yi-Kung, Tung-Tai Kuo, Jonathan Miller, Yung-Hsiao Chiang, Barry J
Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after TBI...
January 20, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28069365/polyunsaturated-fatty-acids-and-recurrent-mood-disorders-phenomenology-mechanisms-and-clinical-application
#3
REVIEW
Erik Messamore, Daniel M Almeida, Ronald J Jandacek, Robert K McNamara
A body of evidence has implicated dietary deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of recurrent mood disorders including major depressive disorder (MDD) and bipolar disorder. Cross-national and cross-sectional evidence suggests that greater habitual intake of n-3 PUFA is associated with reduced risk for developing mood symptoms. Meta-analyses provide strong evidence that patients with mood disorders exhibit low blood n-3 PUFA levels which are associated with increased risk for the initial development of mood symptoms in response to inflammation...
January 6, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28025071/th17-cells-correlate-positively-to-the-structural-and-functional-integrity-of-the-brain-in-bipolar-depression-and-healthy-controls
#4
Sara Poletti, Harm de Wit, Elena Mazza, Annemarie J M Wijkhuijs, Clara Locatelli, Veronica Aggio, Cristina Colombo, Francesco Benedetti, Hemmo A Drexhage
: Abnormalities of T cell-mediated immune activation, in the absence of active somatic immune diseases, have consistently been reported in mood disorders. Apart from being important players in the regulation of cells of the immune system, T cells are essential for normal brain development. We here report studies on the relationship between circulating levels of T helper cells and structural and functional brain imaging in depressed bipolar patients. Since the CCL20-CCR6 axis is an important entry to the brain we differentiated the various T helper cell subpopulations on the basis of their chemokine receptor expression...
December 23, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27988382/the-vagus-nerve-in-appetite-regulation-mood-and-intestinal-inflammation
#5
REVIEW
Kirsteen N Browning, Simon Verheijden, Guy E Boeckxstaens
Although the gastrointestinal (GI) tract contains intrinsic neural plexuses that allow a significant degree of independent control over GI functions, the central nervous system provides extrinsic neural inputs that modulate, regulate and integrate these functions. In particular, the vagus nerve (VN) provides the parasympathetic innervation to the GI tract, co-ordinates the complex interactions between central and peripheral neural control mechanisms. This review will discuss the physiological roles of the afferent (sensory) and motor (efferent) vagus in regulation of appetite, mood and the immune system, as well as the pathophysiological outcomes of VN dysfunction resulting in obesity, mood disorders and inflammation...
December 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27981186/integrating-interleukin-6-into-depression-diagnosis-and-treatment
#6
REVIEW
Georgia E Hodes, Caroline Ménard, Scott J Russo
There is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of IL-6 in mood disorders. We focus on the functional role of peripheral and central release of IL-6 on the development of stress susceptibility and depression-associated behavior. By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, we hope to broaden the way the field thinks about diagnosing and treating mood disorders...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27913990/sirukumab-a-potential-treatment-for-mood-disorders
#7
REVIEW
Aileen J Zhou, Yena Lee, Giacomo Salvadore, Benjamin Hsu, Trehani M Fonseka, Sidney H Kennedy, Roger S McIntyre
Convergent evidence indicates that abnormalities in the innate immune system may be pertinent to the pathogenesis, phenomenology, and possible treatment of several mental disorders. In keeping with this view, the targeting of interleukin-6 with the human monoclonal antibody sirukumab may represent a possible treatment and disease modification approach, for adults with brain-based disorders (e.g., major depressive disorder). A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation...
January 2017: Advances in Therapy
https://www.readbyqxmd.com/read/27865949/lost-in-translation-the-potential-psychobiotic-lactobacillus-rhamnosus-jb-1-fails-to-modulate-stress-or-cognitive-performance-in-healthy-male-subjects
#8
John R Kelly, Andrew P Allen, Andriy Temko, William Hutch, Paul J Kennedy, Niloufar Farid, Eileen Murphy, Geraldine Boylan, John Bienenstock, John F Cryan, Gerard Clarke, Timothy G Dinan
BACKGROUND: Preclinical studies have identified certain probiotics as psychobiotics - live microorganisms with a potential mental health benefit. Lactobacillus rhamnosus (JB-1) has been shown to reduce stress-related behaviour, corticosterone release and alter central expression of GABA receptors in an anxious mouse strain. However, it is unclear if this single putative psychobiotic strain has psychotropic activity in humans. Consequently, we aimed to examine if these promising preclinical findings could be translated to healthy human volunteers...
November 16, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27830574/inflammation-effects-on-brain-glutamate-in-depression-mechanistic-considerations-and-treatment-implications
#9
Ebrahim Haroon, Andrew H Miller
There has been increasing interest in the role of glutamate in mood disorders, especially given the profound effect of the glutamate receptor antagonist ketamine in improving depressive symptoms in patients with treatment-resistant depression. One pathway by which glutamate alterations may occur in mood disorders involves inflammation. Increased inflammation has been observed in a significant subgroup of patients with mood disorders, and inflammatory cytokines have been shown to influence glutamate metabolism through effects on astrocytes and microglia...
2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27824355/neuropathology-of-mood-disorders-do-we-see-the-stigmata-of-inflammation
#10
REVIEW
N Mechawar, J Savitz
A proportion of cases with mood disorders have elevated inflammatory markers in the blood that conceivably may result from stress, infection and/or autoimmunity. However, it is not yet clear whether depression is a neuroinflammatory disease. Multiple histopathological and molecular abnormalities have been found postmortem but the etiology of these abnormalities is unknown. Here, we take an immunological perspective of this literature. Increases in activated microglia or perivascular macrophages in suicide victims have been reported in the parenchyma...
November 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27821270/bipolar-disorder-moderates-associations-between-linoleic-acid-and-markers-of-inflammation
#11
Ya-Wen Chang, Shervin Assari, Alan R Prossin, Laura Stertz, Melvin G McInnis, Simon J Evans
Dietary polyunsaturated fatty acids (PUFA) and inflammatory proteins associate with immune activation and have been implicated in the pathophysiology of mood disorders. We have previously reported that individuals with bipolar disorder (BPD) have decreased PUFA intake, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA); and decreased PUFA concentration of plasma EPA and linoleic acid (LA). We have also reported an association between plasma LA and its metabolites and burden of disease measures in BPD...
February 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27781556/mood-therapeutics-novel-pharmacological-approaches-for-treating-depression
#12
Ioline D Henter, Rafael T de Sousa, Philip W Gold, Andre R Brunoni, Carlos A Zarate, Rodrigo Machado-Vieira
Real-world effectiveness trials suggest that antidepressant efficacy is limited in many patients with mood disorders, underscoring the urgent need for novel therapeutics to treat these disorders. Areas covered: Here, we review the clinical evidence supporting the use of novel modulators for the treatment of mood disorders, including specific glutamate modulators such as: 1) high-trapping glutamatergic modulators; 2) subunit (NR2B)-specific N-methyl-D-aspartate (NMDA) receptor antagonists; 3) NMDA receptor glycine-site partial agonists; and 4) metabotropic glutamate receptor (mGluR) modulators...
February 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27730510/unpredictable-chronic-mild-stress-paradigm-established-effects-of-pro-and-anti-inflammatory-cytokine-on-neurodegeneration-linked-depressive-states-in-hamsters-with-brain-endothelial-damages
#13
Ennio Avolio, Gilda Fazzari, Maria Mele, Raffaella Alò, Merylin Zizza, Wei Jiao, Anna Di Vito, Tullio Barni, Maurizio Mandalà, Marcello Canonaco
The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it was our intention to establish the role of pro- and anti-inflammatory cytokine expression variations towards depression-like behaviors and consequently the development of neurodegeneration events caused by endothelial damages in the hamster (Mesocricetus auratus)...
October 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27724045/p2x7-receptor-antagonists-a-patent-review-2010-2015
#14
Jin-Hee Park, Yong-Chul Kim
The P2X7 receptor (P2X7R) is a unique subtype among the family of seven purinergic P2X receptors, which are ATP-gated non-selective cation channels. P2X7R has been reported to have pathological roles in various diseases, including autoimmune diseases such as arthritis and inflammatory bowel disease, neurodegenerative diseases, chronic pain, mood disorders and cancers. Therefore, many pharmaceutical companies have endeavored to develop a clinical candidate targeting P2X7R. Areas covered: This review provides a summary of various patents on chemicals and biologics and their clinical use published between 2010 and 2015...
October 10, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27677784/role-of-neuro-immunological-factors-in-the-pathophysiology-of-mood-disorders-implications-for-novel-therapeutics-for-treatment-resistant-depression
#15
Anindya Bhattacharya, Wayne C Drevets
Mood disorders are associated with persistently high rates of morbidity and mortality, despite the widespread availability of antidepressant treatments. One limitation to extant therapeutic options has been that nearly all approved antidepressant pharmacotherapies exert a similar primary action of blocking monoamine transporters, and few options exist for transitioning treatment resistant patients to alternatives with distinct mechanisms. An emerging area of science that promises novel pathways to antidepressant and mood-stabilizing therapies has followed from evidence that immunological factors play major roles in the pathophysiology of at least some mood disorder subtypes...
2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27663044/-metabolic-syndrome-and-bipolar-disorder-is-sleep-the-missing-link
#16
H Brochard, C Boudebesse, C Henry, O Godin, M Leboyer, B Étain
OBJECTIVE: To examine the pathophysiologic mechanisms that may link circadian disorder and metabolic syndrome in bipolar disorder (BP). METHOD: A systematic review of the literature was conducted from January 2013 to January 2015, using the Medline and Cochrane databases, using the keywords "metabolic syndrome", "obesity", "leptin" and "circadian disorders", "sleeping disorders" and cross-referencing them with "bipolar disorder". The following types of publications were candidates for review: (i) clinical trials; (ii) studies involving patients diagnosed with bipolar disorder; (iii) studies involving patients with sleeping disorder; or (iv) data about metabolic syndrome...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/27639185/valproic-acid-and-lithium-meditate-anti-inflammatory-effects-by-differentially-modulating-dendritic-cell-differentiation-and-function
#17
Sy-Jye Leu, Yi-Yuan Yang, Hsing-Cheng Liu, Chieh-Yu Cheng, Yu-Chen Wu, Ming-Chyi Huang, Yuen-Lun Lee, Chi-Ching Chen, Winston W Shen, Ko-Jiunn Liu
Valproic acid (VPA), with inhibition activity mainly toward histone deacetylase (HDAC) and Glycogen Synthase Kinase (GSK)-3, and lithium, with inhibition activity mainly toward GSK-3, are both prescribed in clinical as mood-stabilizers and anticonvulsants for the control of bipolar disorder. This study aims to compare the immuno-modulation activities of VPA and lithium, especially on the differentiation and functions of dendritic cells (DC). Our data show that treatment with VPA or lithium effectively alleviated the severity of collagen-induced arthritis triggered by LPS in mice...
May 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27633106/omega-3-polyunsaturated-fatty-acids-and-oxylipins-in-neuroinflammation-and-management-of-alzheimer-disease
#18
REVIEW
Jessay Gopuran Devassy, Shan Leng, Melissa Gabbs, Md Monirujjaman, Harold M Aukema
Alzheimer disease (AD) is becoming one of the most prevalent neurodegenerative conditions worldwide. Although the disease progression is becoming better understood, current medical interventions can only ameliorate some of the symptoms but cannot slow disease progression. Neuroinflammation plays an important role in the advancement of this disorder, and n-3 (ω-3) polyunsaturated fatty acids (PUFAs) are involved in both the reduction in and resolution of inflammation. These effects may be mediated by the anti-inflammatory and proresolving effects of bioactive lipid mediators (oxylipins) derived from n-3 PUFAs [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] in fish oil...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27629368/inflammation-glutamate-and-glia-a-trio-of-trouble-in-mood-disorders
#19
Ebrahim Haroon, Andrew H Miller, Gerard Sanacora
Increasing data indicate that inflammation and alterations in glutamate neurotransmission are two novel pathways to pathophysiology in mood disorders. The primary goal of this review is to illustrate how these two pathways may converge at the level of the glia to contribute to neuropsychiatric disease. We propose that a combination of failed clearance and exaggerated release of glutamate by glial cells during immune activation leads to glutamate increases and promotes aberrant extrasynaptic signaling through ionotropic and metabotropic glutamate receptors, ultimately resulting in synaptic dysfunction and loss...
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27592562/chronic-psychological-stress-and-high-fat-high-fructose-diet-disrupt-metabolic-and-inflammatory-gene-networks-in-the-brain-liver-and-gut-and-promote-behavioral-deficits-in-mice
#20
Maria Elizabeth de Sousa Rodrigues, Mandakh Bekhbat, Madelyn C Houser, Jianjun Chang, Douglas I Walker, Dean P Jones, Claudia M P Oller do Nascimento, Christopher J Barnum, Malú G Tansey
The mechanisms underlying the association between chronic psychological stress, development of metabolic syndrome (MetS), and behavioral impairment in obesity are poorly understood. The aim of the present study was to assess the effects of mild chronic psychological stress on metabolic, inflammatory, and behavioral profiles in a mouse model of diet-induced obesity. We hypothesized that (1) high-fat high-fructose diet (HFHF) and psychological stress would synergize to mediate the impact of inflammation on the central nervous system in the presence of behavioral dysfunction, and that (2) HFHF and stress interactions would impact insulin and lipid metabolism...
January 2017: Brain, Behavior, and Immunity
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