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brain dysfunction sepsis

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https://www.readbyqxmd.com/read/27888550/mesenchymal-stem-stromal-cells-biology-and-preclinical-evidence-for-therapeutic-potential-for-organ-dysfunction-following-trauma-or-sepsis
#1
Michael A Matthay, Shibani Pati, Jae-Woo Lee
Several experimental studies have provided evidence that bone-marrow derived mesenchymal stem (stromal) cells (MSC) may be effective in treating critically ill surgical patients who develop traumatic brain injury, acute renal failure, or the acute respiratory distress syndrome. There is also preclinical evidence that MSC may be effective in treating sepsis-induced organ failure, including evidence that MSC have anti-microbial properties. This review considers preclinical studies with direct relevance to organ failure following trauma, sepsis or major infections that apply to critically ill patients...
November 26, 2016: Stem Cells
https://www.readbyqxmd.com/read/27885885/septic-encephalopathy-and-septic-encephalitis-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#2
Simone C Tauber, Helmut Eiffert, Wolfgang Brück, Roland Nau
During the last two decades, septic encephalopathy (SE) was recognized as a clinically relevant problem with a high prevalence in patients at admission and during their hospital stay. SE is a condition associated with increased mortality and morbidity such as long-term cognitive impairment. Areas covered: This review illustrates the pathophysiology of sepsis-associated encephalopathy and encephalitis involving blood-brain-barrier dysfunction and neuroinflammation caused by endothelial and microglial activation by endogenous or pathogen-derived compounds, hypoxia by impaired microvascular regulation and septic shock as well as imbalance of neurotransmitters...
November 25, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27833044/statins-prevent-cognitive-impairment-after-sepsis-by-reverting-neuroinflammation-and-microcirculatory-endothelial-dysfunction
#3
Patricia A Reis, Pedro C B Alexandre, Joana C D'Avila, Luciana D Siqueira, Barbara Antunes, Vanessa Estato, Eduardo V Tibiriça, Franck Verdonk, Tarek Sharshar, Fabrice Chrétien, Hugo C Castro-Faria-Neto, Fernando A Bozza
Acute brain dysfunction is a frequent condition in sepsis patients and is associated with increased mortality and long-term neurocognitive consequences. Impaired memory and executive function are common findings in sepsis survivors. Although neuroinflammation and blood-brain barrier dysfunction have been associated with acute brain dysfunction and its consequences, no specific treatments are available that prevent cognitive impairment after sepsis. Experimental sepsis was induced in Swiss Webster mice by intraperitoneal injection of cecal material (5 mg/kg, 500 μL)...
November 7, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27798314/cerebral-blood-flow-autoregulation-in-sepsis-for-the-intensivist-why-its-monitoring-may-be-the-future-of-individualized-care
#4
Carrie M Goodson, Kathryn Rosenblatt, Lucia Rivera-Lara, Paul Nyquist, Charles W Hogue
Cerebral blood flow (CBF) autoregulation maintains consistent blood flow across a range of blood pressures (BPs). Sepsis is a common cause of systemic hypotension and cerebral dysfunction. Guidelines for BP management in sepsis are based on historical concepts of CBF autoregulation that have now evolved with the availability of more precise technology for its measurement. In this article, we provide a narrative review of methods of monitoring CBF autoregulation, the cerebral effects of sepsis, and the current knowledge of CBF autoregulation in sepsis...
October 25, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27771396/electroacupuncture-pretreatment-with-different-waveforms-prevents-brain-injury-in-rats-subjected-to-cecal-ligation-and-puncture-via-inhibiting-microglial-activation-and-attenuating-inflammation-oxidative-stress-and-apoptosis
#5
Ye Chen, Yu Lei, Li-Qun Mo, Jun Li, Mao-Hua Wang, Ji-Cheng Wei, Jun Zhou
Sepsis is associated with high morbidity and mortality. This study was to investigate the protective effects of electroacupuncture (EA) pretreatment with different waveforms on septic brain injury in rats and its mechanism. Male Sprague-Dawley rats were pretreated by EA with different waveforms (continuous wave, dilatational wave, or intermittent wave) at Baihui (GV20) and Tsusanli (ST36) acupoints for 30min, and underwent cecal ligation and puncture (CLP) or sham operation. The results showed that EA pretreatment with different waveforms improved survival rate, attenuated encephaledema, brain injury, neuronal apoptosis and cognitive dysfunction, and preserved blood-brain barrier (BBB)...
October 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27730511/p2x7-receptor-signaling-contributes-to-sepsis-associated-brain-dysfunction
#6
Luiz Eduardo Baggio Savio, Mariana G Juste Andrade, Paola de Andrade Mello, Patrícia Teixeira Santana, Aline Cristina Abreu Moreira-Souza, Janaína Kolling, Aline Longoni, Linda Feldbrügge, Yan Wu, Angela T S Wyse, Simon C Robson, Robson Coutinho-Silva
Sepsis results in unfettered inflammation, tissue damage, and multiple organ failure. Diffuse brain dysfunction and neurological manifestations secondary to sepsis are termed sepsis-associated encephalopathy (SAE). Extracellular nucleotides, proinflammatory cytokines, and oxidative stress reactions are associated with delirium and brain injury, and might be linked to the pathophysiology of SAE. P2X7 receptor activation by extracellular ATP leads to maturation and release of IL-1β by immune cells, which stimulates the production of oxygen reactive species...
October 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27614253/bacterial-toxins-activation-of-abbreviated-urea-cycle-in-porcine-cerebral-vascular-smooth-muscle-cells
#7
Rajesh G Mishra, Tzu-Ling Tseng, Mei-Fang Chen, Po-Yi Chen, Tony J-F Lee
Nitric oxide (NO) overproduction via induction of inducible nitric oxide synthase (iNOS) is implicated in vasodilatory shock in sepsis, leading to septic encephalopathy and accelerating cerebral ischemic injury. An abbreviated urea-cycle (L-citrulline-L-arginine-NO cycle) has been demonstrated in cerebral perivascular nitrergic nerves and endothelial cells but not in normal cerebral vascular smooth muscle cell (CVSMC). This cycle indicates that argininosuccinate synthase (ASS) catalyzes L-citrulline (L-cit) conversion to form argininosuccinate (AS), and subsequent AS cleavage by argininosuccinate lyase (ASL) forms L-arginine (L-arg), the substrate for NO synthesis...
September 7, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27525353/interleukin-27-is-elevated-in-sepsis-induced-myocardial-dysfunction-and-mediates-inflammation
#8
Feng Gao, Yuan-Zheng Yang, Xuan-Yun Feng, Ting-Ting Fan, Long Jiang, Rui Guo, Qiong Liu
INTRODUCTION: Interleukin (IL)-27 is an important cytokine involved in many human inflammatory diseases. In this study, we investigated its role in the pathogenesis of sepsis-induced myocardial dysfunction (SIMD). METHODS: Twenty patients with SIMD and 24healthy donors were prospectively enrolled. Expression of IL-27 was detected in serum from SIMD patients by ELISA. Cardiac dysfunction was induced by administration of Escherichia coli lipopolysaccharide (LPS) to C57BL/6 (wild type) or IL-27R(-/-) mice...
December 2016: Cytokine
https://www.readbyqxmd.com/read/27411704/the-neurological-and-cognitive-consequences-of-hyperthermia
#9
REVIEW
Edward James Walter, Mike Carraretto
An elevated temperature has many aetiologies, both infective and non-infective, and while the fever of sepsis probably confers benefit, there is increasing evidence that the central nervous system is particularly vulnerable to damage from hyperthermia. A single episode of hyperthermia may cause short-term neurological and cognitive dysfunction, which may be prolonged or become permanent. The cerebellum is particularly intolerant to the effects of heat. Hyperthermia in the presence of acute brain injury worsens outcome...
July 14, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27401964/sulforaphane-induces-neurovascular-protection-against-a-systemic-inflammatory-challenge-via-both-nrf2-dependent-and-independent-pathways
#10
Paul M Holloway, Scarlett Gillespie, Felix Becker, Shantel A Vital, Victoria Nguyen, J Steven Alexander, Paul C Evans, Felicity N E Gavins
Sepsis is often characterized by an acute brain inflammation and dysfunction, which is associated with increased morbidity and mortality worldwide. Preventing cerebral leukocyte recruitment may provide the key to halt progression of systemic inflammation to the brain. Here we investigated the influence of the anti-inflammatory and anti-oxidant compound, sulforaphane (SFN) on lipopolysaccharide (LPS)-induced cellular interactions in the brain. The inflammatory response elicited by LPS was blunted by SFN administration (5 and 50mg/kg i...
October 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27398623/focal-epileptic-seizures-electroencephalography-and-outcome-of-sepsis-associated-encephalopathy-a-pilot-study
#11
I I Berisavac, V V Padjen, M D Ercegovac, Lj G Beslać-Bumbaširević, P Dj Stanarčević, M S Stefanović-Budimkić, M M Radović, D R Jovanović
OBJECTIVES: Sepsis associated encephalopathy (SAE) represents a diffuse and/or multifactorial cerebral dysfunction during response to systemic infection. Study aim was to compare clinical and electroencephalogram (EEG) characteristics and intrahospital survival rate among SAE patients. PATIENTS AND METHODS: A prospective study, during 42 months' period, included 39 SAE patients assigned in two groups according the outcome (survival: 19, and death: 20 patients). All the patients' features were registered: demography, neurological status, infection type, seizure appearance, brain computerized tomography (CT), EEG, EEG reactivity, Glasgow Coma Score (GCS) and Acute Physiology and Chronic Health Evaluation II (APACHE II) Score...
September 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27272329/-posterior-reversible-encephalopathy-syndrome
#12
M Fischer, E Schmutzhard
Posterior reversible encephalopathy syndrome refers to a neurological disorder characterized by headache, disorders of consciousness, visual disturbances, epileptic seizures, and subcortical vasogenic edema. About two thirds of patients develop neurological symptoms, which are associated with blood pressure fluctuations. One hypothesis is that hypertensive episodes cause autoregulatory failure, and values above the upper limit of cerebral autoregulation result in a breakthrough followed by hyperperfusion and blood-brain barrier dysfunction...
June 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/27270556/nk-cells-promote-neutrophil-recruitment-in-the-brain-during-sepsis-induced-neuroinflammation
#13
Hao He, Tingting Geng, Piyun Chen, Meixiang Wang, Jingxia Hu, Li Kang, Wengang Song, Hua Tang
Sepsis could affect the central nervous system and thus induces neuroinflammation, which subsequently leads to brain damage or dysfunction. However, the mechanisms of generation of neuroinflammation during sepsis remain poorly understood. By administration of lipopolysaccharides (LPS) in mice to mimic sepsis, we found that shortly after opening the blood-brain barrier, conventional CD11b(+)CD27(+) NK subset migrated into the brain followed by subsequent neutrophil infiltration. Interestingly, depletion of NK cells prior to LPS treatment severely impaired neutrophil recruitment in the inflamed brain...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27239312/neurocritical-care-update
#14
REVIEW
Yasuhiro Kuroda
This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temperature modulation, is required. Analgosedation for target temperature management is an essential strategy to prevent shivering and minimizes endogenous stress induced by catecholamine surges. For severe traumatic brain injury, the diverse effects of therapeutic hypothermia depend on the complicated pathophysiology of the condition...
2016: Journal of Intensive Care
https://www.readbyqxmd.com/read/27229649/neuroanatomy-and-physiology-of-brain-dysfunction-in-sepsis
#15
REVIEW
Aurelien Mazeraud, Quentin Pascal, Franck Verdonk, Nicholas Heming, Fabrice Chrétien, Tarek Sharshar
Sepsis-associated encephalopathy (SAE), a complication of sepsis, is often complicated by acute and long-term brain dysfunction. SAE is associated with electroencephalogram pattern changes and abnormal neuroimaging findings. The major processes involved are neuroinflammation, circulatory dysfunction, and excitotoxicity. Neuroinflammation and microcirculatory alterations are diffuse, whereas excitotoxicity might occur in more specific structures involved in the response to stress and the control of vital functions...
June 2016: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/27229490/characterization-of-brain-heart-interactions-in-a-rodent-model-of-sepsis
#16
Bernardo Bollen Pinto, Cristiane Ritter, Monique Michels, Nicolò Gambarotta, Manuela Ferrario, Felipe Dal-Pizzol, Mervyn Singer
Loss of heart rate variability (HRV) and autonomic dysfunction are associated with poor outcomes in critically ill patients. Neuronal networks comprising brainstem and hypothalamus are involved in the "flight-or-fight" response via control over the autonomic nervous system and circulation. We hypothesized that sepsis-induced inflammation in brain regions responsible for autonomic control is associated with sympathovagal imbalance and depressed contractility. Sepsis was induced by fecal slurry injection in fluid-resuscitated rats...
May 26, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27223862/preventive-strategies-and-potential-therapeutic-interventions-for-delirium-in-sepsis
#17
Vicente Cés Souza-Dantas, Pedro Póvoa, Fernando Bozza, Marcio Soares, Jorge Salluh
Delirium is the most frequent and severe clinical presentation of brain dysfunction in critically ill septic patients with an incidence ranging from 9% to 71%. Delirium represents a significant burden for patients and relatives, as well as to the health care system, resulting in higher costs, long-term cognitive impairment and significant risk of death after 6 months. Current interventions for the prevention of delirium typically involve early recognition and amelioration of modifiable risk factors and treatment of underlying conditions that predisposes the individual to delirium...
June 3, 2016: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/27172161/%C3%AE-blockade-use-for-traumatic-injuries-and-immunomodulation-a-review-of-proposed-mechanisms-and-clinical-evidence
#18
Tyler J Loftus, Philip A Efron, Lyle L Moldawer, Alicia M Mohr
Sympathetic nervous system activation and catecholamine release are important events following injury and infection. The nature and timing of different pathophysiologic insults have significant effects on adrenergic pathways, inflammatory mediators, and the host response. Beta adrenergic receptor blockers (β-blockers) are commonly used for treatment of cardiovascular disease, and recent data suggests that the metabolic and immunomodulatory effects of β-blockers can expand their use. β-blocker therapy can reduce sympathetic activation and hypermetabolism as well as modify glucose homeostasis and cytokine expression...
October 2016: Shock
https://www.readbyqxmd.com/read/27156563/brain-ultrasonographic-findings-of-late-onset-circulatory-dysfunction-due-to-adrenal-insufficiency-in-preterm-infants
#19
Su-Mi Shin, Jee Won Chai
PURPOSE: The aim of this study was to characterize the brain ultrasonographic findings of late-onset circulatory dysfunction (LCD) due to adrenal insufficiency (AI) in preterm infants. METHODS: Among the 257 preterm infants born at <33 weeks of gestation between December 2009 and February 2014 at our institution, 35 preterm infants were diagnosed with AI. Brain ultrasonographic findings were retrospectively analyzed before and after LCD in 14 preterm infants, after exclusion of the other 21 infants with AI due to the following causes: death (n=2), early AI (n=5), sepsis (n=1), and patent ductus arteriosus (n=13)...
July 2016: Ultrasonography
https://www.readbyqxmd.com/read/27145751/regulation-of-the-cerebral-circulation-bedside-assessment-and-clinical-implications
#20
REVIEW
Joseph Donnelly, Karol P Budohoski, Peter Smielewski, Marek Czosnyka
Regulation of the cerebral circulation relies on the complex interplay between cardiovascular, respiratory, and neural physiology. In health, these physiologic systems act to maintain an adequate cerebral blood flow (CBF) through modulation of hydrodynamic parameters; the resistance of cerebral vessels, and the arterial, intracranial, and venous pressures. In critical illness, however, one or more of these parameters can be compromised, raising the possibility of disturbed CBF regulation and its pathophysiologic sequelae...
May 5, 2016: Critical Care: the Official Journal of the Critical Care Forum
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