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Jin-Yi Wan, Yu-Zhen Zhang, Jin-Bin Yuan, Feng-Qing Yang, Yan Chen, Lian-Di Zhou, Qi-Hui Zhang
Pulsatilla chinensis (Bunge) Regel has been commonly used in Asia, and Anemoside B4 conducted as its major saponin with diverse pharmaceutical effects. Previous studies showed that intestinal flora plays an important role in the metabolism of herbs administered orally. In this study, the metabolic profile of AB4 with microflora in rat small and large intestine in vitro was investigated. Gut microflora was collected from different intestinal segments and anaerobically incubated with AB4 at 37 °C for 24, 48, 72 and 96 h, respectively...
October 19, 2016: Biomedical Chromatography: BMC
Laura Q Rogers, Kerry S Courneya, Phillip M Anton, Patricia Hopkins-Price, Steven Verhulst, Randall S Robbs, Sandra K Vicari, Edward McAuley
BACKGROUND: Most breast cancer survivors do not meet physical activity recommendations. Understanding mediators of physical activity behavior change can improve interventions designed to increase physical activity in this at-risk population. PURPOSE: Study aims were to determine the 3-month Better Exercise Adherence after Treatment for Cancer (BEAT Cancer) behavior change intervention effects on social cognitive theory constructs and the mediating role of any changes on the increase in accelerometer-measured physical activity previously reported...
October 17, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Perrine Rasschaert, Thomas Figueroa, Ginette Dambrine, Denis Rasschaert, Sylvie Laurent
Interplay between alternative splicing and the Microprocessor may have differential effects on the expression of intronic miRNAs organised into clusters. We used a viral model - the LAT long non-coding RNA (LAT lncRNA) of Marek's disease oncogenic herpesvirus (MDV-1), which has the mdv1-miR-M8-M6-M7-M10 cluster embedded in its first intron - to assess the impact of splicing modifications on the biogenesis of each of the miRNAs from the cluster. Drosha silencing and alternative splicing of an extended exon 2 of the LAT lncRNA from a newly identified 3' splice site (SS) at the end of the second miRNA of the cluster showed that mdv1-miR-M6 was a 5'-tailed mirtron...
October 7, 2016: RNA Biology
Martin N Stienen, Holger Joswig, Nicolas R Smoll, Marco V Corniola, Karl Schaller, Gerhard Hildebrandt, Oliver P Gautschi
OBJECTIVE: To analyse the influence of body mass index (BMI) on subjective and objective measures of pain, functional impairment and health-related quality of life (hrQoL) in patients with lumbar degenerative disc disease (DDD) undergoing surgery. METHODS: Prospective IRB-approved two-center study, measuring visual analogue scale (VAS) back and leg pain, Roland-Morris Disability Index (RMDI) and Oswestry Disability Index (ODI), Euro-Qol (EQ-5D) and Short Form-12 (SF-12 PCS) at baseline, six weeks (W6), six months (M6) and one year (Y1) postoperatively...
September 26, 2016: World Neurosurgery
Si Young Jang, Ron Lalonde, Cihat Ozhasoglu, Steven Burton, Dwight Heron, M Saiful Huq
We performed an evaluation of the CyberKnife InCise MLC by comparing plan qualities for single and multiple brain lesions generated using the first version of InCise MLC, fixed cone, and Iris collimators. We also investigated differences in delivery efficiency among the three collimators. Twenty-four patients with single or multiple brain mets treated previously in our clinic on a CyberKnife M6 using cone/Iris collimators were selected for this study. Treatment plans were generated for all lesions using the InCise MLC...
2016: Journal of Applied Clinical Medical Physics
Catherine Montaut, Xavier Gamé, Xavier de Boissezon, Philippe Marque, Evelyne Castel-Lacanal
OBJECTIVE: Lower urinary tract dysfunctions (LUTD) are very common in neurological diseases. TENS is a therapeutic alternative in the treatment of urinary and pelvic perineal symptoms, whose effectiveness has been proven in multiple sclerosis. Evaluate the benefits of treatment with TENS (U3 program) in clinical practice for neurological lower urinary tract dysfunctions (LUTD), incompletely controlled by the usual pharmacological treatment, on urinary symptoms and quality of life. MATERIALS/PATIENTS AND METHODS: We performed a cohort, and prospective study, between June 2014 and September 2015 in the Physical Medicine and Rehabilitation Service in CHU Toulouse, Rangueil...
September 2016: Annals of Physical and Rehabilitation Medicine
Walaa K Mousa, Charles Shearer, Victor Limay-Rios, Cassie L Ettinger, Jonathan A Eisen, Manish N Raizada
The ancient African crop, finger millet, has broad resistance to pathogens including the toxigenic fungus Fusarium graminearum. Here, we report the discovery of a novel plant defence mechanism resulting from an unusual symbiosis between finger millet and a root-inhabiting bacterial endophyte, M6 (Enterobacter sp.). Seed-coated M6 swarms towards root-invading Fusarium and is associated with the growth of root hairs, which then bend parallel to the root axis, subsequently forming biofilm-mediated microcolonies, resulting in a remarkable, multilayer root-hair endophyte stack (RHESt)...
2016: Nature Microbiology
Jianli Zhang, Jianghai Lu, Yun Wu, Xiaobing Wang, Youxuan Xu, Yinong Zhang, Yan Wang
In this study, methasterone urinary metabolic profiles were investigated by liquid chromatography quadrupole time of flight mass spectrometry (LC-QTOF-MS) in full scan and targeted MS/MS modes with accurate mass measurement. A healthy male volunteer was asked to take the drug and liquid-liquid extraction was employed to process urine samples. Chromatographic peaks for potential metabolites were hunted out with the theoretical [M - H](-) as a target ion in a full scan experiment and actual deprotonated ions were studied in targeted MS/MS experiment...
2016: International Journal of Molecular Sciences
B Coffin, V Maunoury, F Pattou, X Hébuterne, S Schneider, M Coupaye, S Ledoux, F Iglicki, F Mion, M Robert, E Disse, J Escourrou, G Tuyeras, Y Le Roux, C Arvieux, P Pouderoux, N Huten, T Alfaiate, D Hajage, S Msika
BACKGROUND: Super obese patients are recommended to lose weight before bariatric surgery. The effect of intragastric balloon (IGB)-induced weight loss before laparoscopic gastric bypass (LGBP) has not been reported. The aim of this prospective randomized multicenter study was to compare the impact of preoperative 6-month IGB with standard medical care (SMC) in LGBP patients. METHODS: Patients with BMI >45 kg/m(2) selected for LGBP were included and randomized to receive either SMC or IGB...
September 23, 2016: Obesity Surgery
Dezhi Liu, Fabien Scalzo, Neal M Rao, Jason D Hinman, Doojin Kim, Latisha K Ali, Jeffrey L Saver, Wen Sun, Qiliang Dai, Xinfeng Liu, David S Liebeskind
BACKGROUND AND PURPOSE: In acute arterial occlusion, fluid-attenuated inversion recovery vascular hyperintensity (FVH) has been linked to slow flow in leptomeningeal collaterals and cerebral hypoperfusion, but the impact on clinical outcome is still controversial. In this study, we aimed to investigate the association between FVH topography or FVH-Alberta Stroke Program Early CT Score (ASPECTS) pattern and outcome in acute M1-middle cerebral artery occlusion patients with endovascular treatment...
September 22, 2016: Stroke; a Journal of Cerebral Circulation
Quan Dong Nguyen, Mohammad Ali Sadiq, Mohamed Kamel Soliman, Aniruddha Agarwal, Diana V Do, Yasir J Sepah
PURPOSE: To determine if two different doses of intravitreal sirolimus, an mTOR inhibitor, can decrease inflammation and is safe in eyes with non-infectious posterior, intermediate, or panuveitis in the Sirolimus as a Therapeutic Approach UVEitis: Protocol-2 (SAVE-2) Study. METHODS: SAVE-2 is a prospective randomized, phase II, open-label interventional clinical trial conducted at 4 clinical centers in the United States. Eligible subjects were randomized into one of two treatments...
August 2016: Transactions of the American Ophthalmological Society
Stefan H A M Leenders, René Becker, Tatu Kumpulainen, Bas de Bruin, Tomohisa Sawada, Taito Kato, Makoto Fujita, Joost N H Reek
There is broad interest in molecular encapsulation as such systems can be utilized to stabilize guests, facilitate reactions inside a cavity, or give rise to energy-transfer processes in a confined space. Detailed understanding of encapsulation events is required to facilitate functional molecular encapsulation. In this contribution, it is demonstrated that Ir and Rh-Cp-type metal complexes can be encapsulated inside a self-assembled M6 L4 metallocage only in the presence of an aromatic compound as a second guest...
October 17, 2016: Chemistry: a European Journal
Marija Zivanovic, Ron Ricardo Walcott
Bacterial fruit blotch of cucurbits (BFB) is caused by the Gram negative bacterium Acidovorax citrulli whose populations can be distinguished into two genetically distinct groups, I and II. Based on visual assessment of BFB severity on cucurbit seedlings and fruits after inoculation under greenhouse conditions, group I A. citrulli strains have been reported to be moderately to highly virulent on several cucurbit hosts, while group II strains have exhibited high virulence on watermelon, but low virulence on other cucurbits...
September 12, 2016: Phytopathology
X An, B-M Feng, G Chen, S-F Chen, J Bai, H-M Hua, H-F Wang, Y-H Pei
1. Butyrolactone I (BL-I), one of the major secondary metabolites of fungus Aspergillus terreus, is a selective cdc2 kinase inhibitor. In the present study, the metabolism of BL-I in male Wistar rats was investigated by characterizing metabolites excreted into feces. 2. Following an oral dose of 40 mg/kg BL-I, 10 phase I metabolites were isolated from the feces of rats, and their structures were identified on the basis of a range of spectroscopic data and ICD analysis. These metabolites were fully characterized as butyrolactone VI (M1), aspernolide E (M2), 7''S-hydroxy-9''-ene-butyrolactone I (M3), 7''R-hydroxy-9''-ene-butyrolactone I (M4), 7″S, 8″R-dihydroxy-aspernolide E (M5), 7″R, 8″S-dihydroxy-aspernolide E (M6), 7″R-acetyl-8″S-hydroxy-aspernolide E (M7), 7″S-acetyl-8″R-hydroxy-aspernolide E (M8), 7″R-methoxy-8″S-hydroxy-aspernolide E (M9), butyrolactone V (M10), respectively...
September 8, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Pengfei Ji, Kuntal Manna, Zekai Lin, Ania Urban, Francis X Greene, Guangxu Lan, Wenbin Lin
We report here the synthesis of robust and porous metal-organic frameworks (MOFs), M-MTBC (M = Zr or Hf), constructed from the tetrahedral linker methane-tetrakis(p-biphenylcarboxylate) (MTBC) and two types of secondary building units (SBUs): cubic M8(μ2-O)8(μ2-OH)4 and octahedral M6(μ3-O)4(μ3-OH)4. While the M6-SBU is isostructural with the 12-connected octahedral SBUs of UiO-type MOFs, the M8-SBU is composed of eight M(IV) ions in a cubic fashion linked by eight μ2-oxo and four μ2-OH groups. The metalation of Zr-MTBC SBUs with CoCl2, followed by treatment with NaBEt3H, afforded highly active and reusable solid Zr-MTBC-CoH catalysts for the hydrogenation of alkenes, imines, carbonyls, and heterocycles...
September 21, 2016: Journal of the American Chemical Society
In Sook Kim, Shaheed Ur Rehman, Min Sun Choi, Moonhee Jang, Wonkyung Yang, Eunmi Kim, Hye Hyun Yoo
Methylenedioxypyrovalerone (MDPV) has emerged in recent years as a recreational substance with psychostimulant properties. In this study, in vitro metabolites of MDPV were characterized based on liquid chromatography/quadrupole-time-of-flight mass spectrometry (LC/QTOF MS). MDPV was incubated with human liver microsomes, human recombinant cDNA-expressed cytochrome P450 enzymes and flavin monooxygenase (FMO). MDPV was metabolized to yield eight metabolites (M1-M8) with major metabolic reactions such as demethylenation and oxidation...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
Philippe Nubukpo, Murielle Girard, Jean-Marie Sengelen, Sophie Bonnefond, Aurélien Varnoux, Benoît Marin, Dominique Malauzat
BACKGROUND: The objective of this study was to describe the profile and alcoholic status of a population with alcohol use disorders (AUD) requesting help from a psychiatric hospital to stop drinking, as well as their clinical outcome and care consumption over the 2 years following the request. METHODS: The visits were conducted at baseline (M0) and at 6, 12, 18 and 24 months (M6, M12, M18, M24). Demographic, clinical and psychometric data [Beck Depression Inventory (BDI), AUDIT questionnaire, Global Assessment of Functioning (GAF) scale], and information regarding the use of psychiatric care and therapeutics were collected...
2016: Annals of General Psychiatry
Yue Liu, Clinton E Canal, Tania C Cordova-Sintjago, Wanying Zhu, Raymond G Booth
While exploring the structure-activity relationship of 4-phenyl-2-dimethylaminotetralins (PATs) at serotonin 5-HT2C receptors, we discovered that relatively minor modification of PAT chemistry impacts function at 5-HT2C receptors. In HEK293 cells expressing human 5-HT2C-INI receptors, for example, (-)-trans-3'-Br-PAT and (-)-trans-3'-Cl-PAT are agonists regarding Gαq-inositol phosphate signaling, whereas (-)-trans-3'-CF3-PAT is an inverse agonist. To investigate the ligand-receptor interactions that govern this change in function, we performed site-directed mutagenesis of 14 amino acids of the 5-HT2C receptor based on molecular modeling and reported G protein-coupled receptor crystal structures, followed by molecular pharmacology studies...
October 10, 2016: ACS Chemical Neuroscience
Lei Wang, Benjamin Fahimian, Scott G Soltys, Paul Zei, Anthony Lo, Edward A Gardner, Patrick J Maguire, Billy W Loo
PURPOSE: The first stereotactic arrhythmia radioablation (STAR) of ventricular tachycardia (VT) was delivered at Stanford on a robotic radiosurgery system (CyberKnife® G4) in 2012. The results warranted further investigation of this treatment. Here we compare dosimetrically three possible treatment delivery platforms for STAR. METHODS: The anatomy and target volume of the first treated patient were used for this study. A dose of 25 Gy in one fraction was prescribed to the planning target volume (PTV)...
2016: Curēus
K Morisseau, A Joubert, L Le Coq, Y Andres
This study aimed to demonstrate that particles, especially those associated with fungi, could be released from fibrous filters used in the air-handling unit (AHU) of heating, ventilation and air-conditioning (HVAC) systems during ventilation restarts. Quantification of the water retention capacity and SEM pictures of the filters was used to show the potential for fungal proliferation in unused or preloaded filters. Five fibrous filters with various particle collection efficiencies were studied: classes G4, M5, M6, F7, and combined F7 according to European standard EN779:2012...
August 26, 2016: Indoor Air
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