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https://www.readbyqxmd.com/read/27913887/transcriptomics-analysis-of-hulless-barley-during-grain-development-with-a-focus-on-starch-biosynthesis
#1
Yawei Tang, Xingquan Zeng, Yulin Wang, Lijun Bai, Qijun Xu, Zexiu Wei, Hongjun Yuan, Tashi Nyima
Hulless barley, with its unique nutritional value and potential health benefits, has increasingly attracted attentions in recent years. However, the transcription dynamics during hulless barley grain development is not well understood. In the present study, we investigated the transcriptome changes during barley grain development using Illumina paired-end RNA-sequencing. Two datasets of the developing grain transcriptomes from two barley landraces with the differential seed starch synthesis traits were generated, and comparative transcriptome approach in both genotypes was performed...
December 2, 2016: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/27882114/apc2-and-cyp1b1-methylation-changes-in-the-bone-marrow-of-acute-myeloid-leukemia-patients-during-chemotherapy
#2
Yongming Xia, Qingxiao Hong, Xiaoying Chen, Huadan Ye, Lili Fang, Annan Zhou, Yuting Gao, Danjie Jiang, Shiwei Duan
Aberrant promoter DNA methylation is a major mechanism of leukemogenesis in hematologic malignancies, including acute myeloid leukemia (AML). However, the association between promoter methylation with chemotherapeutic outcomes remains unknown. In the present study, bone marrow samples were collected prior to and following chemotherapy in 30 AML patients. Methylation-specific polymerase chain reaction technology was used to examine the promoter methylation status of adenomatous polyposis col 2 (APC2) and cytochrome P450 family 1 subfamily B polypeptide 1 (CYP1B1)...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27873048/the-usefulness-of-radiological-grading-scales-to-predict-pain-intensity-functional-impairment-and-health-related-quality-of-life-after-surgery-for-lumbar-degenerative-disc-disease
#3
Oliver P Gautschi, Martin N Stienen, Holger Joswig, Nicolas R Smoll, Karl Schaller, Marco V Corniola
PURPOSE: The goal of this study is to determine the relationship of radiological grading scales of lumbar degenerative disc disease (DDD) with postoperative pain intensity, functional impairment, and health-related quality of life (HRQoL). METHODS: Response to surgical treatment at 6 weeks (W6) on the visual analogue scale (VAS) for back and leg pain, Oswestry-Disability (ODI) and Roland-Morris Disability Index (RMDI), Timed Up and Go (TUG) test, EuroQol (EQ) 5D, and Short-Form Health-Survey (SF-12) physical component summary (PCS) was compared between patients with different Modic (MOD) and Pfirrmann (PFI) grades...
November 21, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27852053/therapy-related-acute-myeloid-leukemia-following-treatment-of-lymphoid-malignancies
#4
Sarah Bertoli, Arthur Sterin, Suzanne Tavitian, Lucie Oberic, Loïc Ysebaert, Reda Bouabdallah, François Vergez, Audrey Sarry, Emilie Bérard, Françoise Huguet, Guy Laurent, Thomas Prébet, Norbert Vey, Christian Récher
Therapy-related acute myeloid leukemia (t-AML) is a heterogeneous entity most frequently related to breast cancer or lymphoproliferative diseases (LD). Population-based studies have reported an increased risk of t-AML after treatment of lymphomas. The aim of this study was to describe the characteristics and outcome of 80 consecutive cases of t-AML following treatment of LD. t-AML accounted for 2.3% of all AML cases, occurred 60 months after LD diagnosis, and were characterized by a high frequency of FAB M6 AML and poor-risk cytogenetic abnormalities...
November 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27846631/prognostic-factors-and-pattern-of-long-term-recovery-with-mlc601-neuroaid%C3%A2-in-the-chinese-medicine-neuroaid-efficacy-on-stroke-recovery-extension-study
#5
Narayanaswamy Venketasubramanian, Chun Fan Lee, Sherry H Young, San San Tay, Thirugnanam Umapathi, Annabelle Y Lao, Herminigildo H Gan, Alejandro C Baroque Ii, Jose C Navarro, Hui Meng Chang, Joel M Advincula, Sombat Muengtaweepongsa, Bernard P L Chan, Carlos L Chua, Nirmala Wijekoon, H Asita de Silva, John Harold B Hiyadan, Nijasri C Suwanwela, K S Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Christopher L H Chen
BACKGROUND: The Chinese Medicine NeuroAiD Efficacy on Stroke recovery - Extension (CHIMES-E) study is among the few acute stroke trials with long-term outcome data. We aimed to evaluate the recovery pattern and the influence of prognostic factors on treatment effect of MLC601 over 2 years. METHODS: The CHIMES-E study evaluated the 2 years outcome of subjects aged ≥18 years with acute ischemic stroke, National Institutes of Health Stroke Scale (NIHSS) score 6-14, pre-stroke modified Rankin Scale (mRS) score ≤1 included in a multicenter, randomized, double-blind, placebo-controlled trial of MLC601 for 3 months...
November 15, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27830193/human-norovirus-aptamer-exhibits-high-degree-of-target-conformation-dependent-binding-similar-to-that-of-receptors-and-discriminates-particle-functionality
#6
Matthew D Moore, Benjamin G Bobay, Brittany Mertens, Lee-Ann Jaykus
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR. Histo-blood group antigen (HBGA) binding assays serve as a proxy for estimation of infectious particles; however, they are costly and difficult to purify/modify. Some evidence suggests that certain nucleic acid aptamers only bind intact target proteins, thus displaying a high degree of conformation-dependent binding...
November 2016: MSphere
https://www.readbyqxmd.com/read/27827510/synthesis-of-natural-urolithin-m6-a-galloflavin-mimetic-as-a-potential-inhibitor-of-lactate-dehydrogenase-a
#7
Sebastiano Rupiani, Laura Guidotti, Marcella Manerba, Lorenza Di Ianni, Elisa Giacomini, Federico Falchi, Giuseppina Di Stefano, Marinella Roberti, Maurizio Recanatini
Glycolysis is the main route for energy production in tumors. LDH-A is a key enzyme of this process and its inhibition represents an attractive strategy to hamper cancer cell metabolism. Galloflavin is a reliable LDH-A inhibitor as previously identified by us; however, its poor physicochemical properties and chemical tractability render it unsuitable for further development. Therefore, a rational design was undertaken with the aim to reproduce the pharmacophore of galloflavin on simpler, potentially more soluble and synthetic accessible scaffolds...
November 9, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27815383/persistence-of-wild-type-japanese-encephalitis-virus-strains-cross-neutralization-five-years-following-je-cv-immunization
#8
Emmanuel Feroldi, Mark Boaz, Sutee Yoksan, Kulkanya Chokephaibulkit, Usa Thisyakorn, Chitsanu Pancharoen, Céline Monfredo, Alain Bouckenooghe
BACKGROUND:  The live-attenuated Japanese encephalitis (JE) vaccine (JE-CV; IMOJEV(®)) induces a protective response in children. A shift in circulating JE virus strains suggests that a genotype shift phenomenon may occur throughout South-East Asia. We assessed the neutralization of wild-type (WT) JE virus isolates at distal time points post-vaccination. METHODS:  We analysed serum samples from a subset of 47 children who had received a JE-CV booster after an inactivated JE vaccine primary immunization...
November 3, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27792891/development-of-hplc-and-lc-ms-ms-methods-for-the-analysis-of-ivacaftor-its-major-metabolites-and-lumacaftor-in-plasma-and-sputum-of-cystic-fibrosis-patients-treated-with-orkambi-or-kalydeco
#9
Elena K Schneider, Felisa Reyes-Ortega, John W Wilson, Tom Kotsimbos, Dominic Keating, Jian Li, Tony Velkov
ORKAMBI (ivacaftor-lumacaftor [LUMA]) and KALYDECO (ivacaftor; IVA) are two new breakthrough cystic fibrosis (CF) drugs that directly modulate the activity and trafficking of the defective CFTR underlying the CF disease state. Currently, no therapeutic drug monitoring assays exist for these very expensive, albeit, important drugs. In this study, for the first time HPLC and LC-MS methods were developed and validated for rapid detection and quantification of IVA and its major metabolites hydroxymethyl-IVA M1 (active) and IVA-carboxylate M6 (inactive); and LUMA in the plasma and sputum of CF patients...
October 24, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27784824/durability-of-the-beneficial-effect-of-mlc601-neuroaid%C3%A2-on-functional-recovery-among-stroke-patients-from-the-philippines-in-the-chimes-and-chimes-e-studies
#10
Jose C Navarro, Christopher Lh Chen, Chun F Lee, Herminigildo H Gan, Annabelle Y Lao, Alejandro C Baroque, John Harold B Hiyadan, Carlos L Chua, Ma Cristina San Jose, Joel M Advincula, Narayanaswamy Venketasubramanian
BACKGROUND AND AIM: A pre-specified country analysis of subjects from the Philippines in the CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) Study showed significantly improved functional and neurological outcomes on MLC601 at month (M) 3. We aimed to assess these effects on long-term functional recovery in the Filipino cohort. METHODS: The CHIMES-E (extension) Study evaluated subjects who completed three months of randomized placebo-controlled treatment in CHIMES up to two years...
October 26, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27761923/biotransformation-and-metabolic-profile-of-anemoside-b4-with-rat-small-and-large-intestine-microflora-by-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry
#11
Jin-Yi Wan, Yu-Zhen Zhang, Jin-Bin Yuan, Feng-Qing Yang, Yan Chen, Lian-Di Zhou, Qi-Hui Zhang
Pulsatilla chinensis (Bunge) Regel has been commonly used in Asia, and Anemoside B4 conducted as its major saponin with diverse pharmaceutical effects. Previous studies showed that intestinal flora plays an important role in the metabolism of herbs administered orally. In this study, the metabolic profile of AB4 with microflora in rat small and large intestine in vitro was investigated. Gut microflora was collected from different intestinal segments and anaerobically incubated with AB4 at 37 °C for 24, 48, 72 and 96 h, respectively...
October 19, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27752993/social-cognitive-constructs-did-not-mediate-the-beat-cancer-intervention-effects-on-objective-physical-activity-behavior-based-on-multivariable-path-analysis
#12
Laura Q Rogers, Kerry S Courneya, Phillip M Anton, Patricia Hopkins-Price, Steven Verhulst, Randall S Robbs, Sandra K Vicari, Edward McAuley
BACKGROUND: Most breast cancer survivors do not meet physical activity recommendations. Understanding mediators of physical activity behavior change can improve interventions designed to increase physical activity in this at-risk population. PURPOSE: Study aims were to determine the 3-month Better Exercise Adherence after Treatment for Cancer (BEAT Cancer) behavior change intervention effects on social cognitive theory constructs and the mediating role of any changes on the increase in accelerometer-measured physical activity previously reported...
October 17, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27715458/alternative-splicing-of-a-viral-mirtron-differentially-affects-the-expression-of-other-micrornas-from-its-cluster-and-of-the-host-transcript
#13
Perrine Rasschaert, Thomas Figueroa, Ginette Dambrine, Denis Rasschaert, Sylvie Laurent
Interplay between alternative splicing and the Microprocessor may have differential effects on the expression of intronic miRNAs organized into clusters. We used a viral model - the LAT long non-coding RNA (LAT lncRNA) of Marek's disease oncogenic herpesvirus (MDV-1), which has the mdv1-miR-M8-M6-M7-M10 cluster embedded in its first intron - to assess the impact of splicing modifications on the biogenesis of each of the miRNAs from the cluster. Drosha silencing and alternative splicing of an extended exon 2 of the LAT lncRNA from a newly identified 3' splice site (SS) at the end of the second miRNA of the cluster showed that mdv1-miR-M6 was a 5'-tailed mirtron...
October 7, 2016: RNA Biology
https://www.readbyqxmd.com/read/27686509/influence-of-body-mass-index-on-subjective-and-objective-measures-of-pain-functional-impairment-and-health-related-quality-of-life-in-lumbar-degenerative-disc-disease
#14
Martin N Stienen, Holger Joswig, Nicolas R Smoll, Marco V Corniola, Karl Schaller, Gerhard Hildebrandt, Oliver P Gautschi
OBJECTIVE: To analyze the influence of body mass index (BMI) on subjective and objective measures of pain, functional impairment, and health-related quality of life in patients with lumbar degenerative disc disease undergoing surgery. METHODS: Prospective institutional review board-approved 2-center study, measuring visual analog scale (VAS) back and leg pain, Roland-Morris Disability Index (RMDI), Oswestry Disability Index (ODI), EuroQol 5D questionnaire, and Short Form-12 at baseline, 6 weeks, 6 months, and 1 year postoperatively...
September 28, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27685124/dosimetric-comparison-between-cone-iris-based-and-incise-mlc-based-cyberknife-plans-for-single-and-multiple-brain-metastases
#15
Si Young Jang, Ron Lalonde, Cihat Ozhasoglu, Steven Burton, Dwight Heron, M Saiful Huq
We performed an evaluation of the CyberKnife InCise MLC by comparing plan qualities for single and multiple brain lesions generated using the first version of InCise MLC, fixed cone, and Iris collimators. We also investigated differences in delivery efficiency among the three collimators. Twenty-four patients with single or multiple brain mets treated previously in our clinic on a CyberKnife M6 using cone/Iris collimators were selected for this study. Treatment plans were generated for all lesions using the InCise MLC...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27676713/evaluation-of-the-benefits-of-treatment-with-tens-for-neurological-lower-urinary-tract-dysfunctions
#16
Catherine Montaut, Xavier Gamé, Xavier de Boissezon, Philippe Marque, Evelyne Castel-Lacanal
OBJECTIVE: Lower urinary tract dysfunctions (LUTD) are very common in neurological diseases. TENS is a therapeutic alternative in the treatment of urinary and pelvic perineal symptoms, whose effectiveness has been proven in multiple sclerosis. Evaluate the benefits of treatment with TENS (U3 program) in clinical practice for neurological lower urinary tract dysfunctions (LUTD), incompletely controlled by the usual pharmacological treatment, on urinary symptoms and quality of life. MATERIALS/PATIENTS AND METHODS: We performed a cohort, and prospective study, between June 2014 and September 2015 in the Physical Medicine and Rehabilitation Service in CHU Toulouse, Rangueil...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27669453/root-hair-endophyte-stacking-in-finger-millet-creates-a-physicochemical-barrier-to-trap-the-fungal-pathogen-fusarium-graminearum
#17
Walaa K Mousa, Charles Shearer, Victor Limay-Rios, Cassie L Ettinger, Jonathan A Eisen, Manish N Raizada
The ancient African crop, finger millet, has broad resistance to pathogens including the toxigenic fungus Fusarium graminearum. Here, we report the discovery of a novel plant defence mechanism resulting from an unusual symbiosis between finger millet and a root-inhabiting bacterial endophyte, M6 (Enterobacter sp.). Seed-coated M6 swarms towards root-invading Fusarium and is associated with the growth of root hairs, which then bend parallel to the root axis, subsequently forming biofilm-mediated microcolonies, resulting in a remarkable, multilayer root-hair endophyte stack (RHESt)...
2016: Nature Microbiology
https://www.readbyqxmd.com/read/27669235/new-potential-biomarker-for-methasterone-misuse-in-human-urine-by-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#18
Jianli Zhang, Jianghai Lu, Yun Wu, Xiaobing Wang, Youxuan Xu, Yinong Zhang, Yan Wang
In this study, methasterone urinary metabolic profiles were investigated by liquid chromatography quadrupole time of flight mass spectrometry (LC-QTOF-MS) in full scan and targeted MS/MS modes with accurate mass measurement. A healthy male volunteer was asked to take the drug and liquid-liquid extraction was employed to process urine samples. Chromatographic peaks for potential metabolites were hunted out with the theoretical [M - H](-) as a target ion in a full scan experiment and actual deprotonated ions were studied in targeted MS/MS experiment...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27664095/impact-of-intragastric-balloon-before-laparoscopic-gastric-bypass-on-patients-with-super-obesity-a-randomized-multicenter-study
#19
B Coffin, V Maunoury, F Pattou, X Hébuterne, S Schneider, M Coupaye, S Ledoux, F Iglicki, F Mion, M Robert, E Disse, J Escourrou, G Tuyeras, Y Le Roux, C Arvieux, P Pouderoux, N Huten, T Alfaiate, D Hajage, S Msika
BACKGROUND: Super obese patients are recommended to lose weight before bariatric surgery. The effect of intragastric balloon (IGB)-induced weight loss before laparoscopic gastric bypass (LGBP) has not been reported. The aim of this prospective randomized multicenter study was to compare the impact of preoperative 6-month IGB with standard medical care (SMC) in LGBP patients. METHODS: Patients with BMI >45 kg/m(2) selected for LGBP were included and randomized to receive either SMC or IGB...
September 23, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27659851/fluid-attenuated-inversion-recovery-vascular-hyperintensity-topography-novel-imaging-marker-for-revascularization-in-middle-cerebral-artery-occlusion
#20
Dezhi Liu, Fabien Scalzo, Neal M Rao, Jason D Hinman, Doojin Kim, Latisha K Ali, Jeffrey L Saver, Wen Sun, Qiliang Dai, Xinfeng Liu, David S Liebeskind
BACKGROUND AND PURPOSE: In acute arterial occlusion, fluid-attenuated inversion recovery vascular hyperintensity (FVH) has been linked to slow flow in leptomeningeal collaterals and cerebral hypoperfusion, but the impact on clinical outcome is still controversial. In this study, we aimed to investigate the association between FVH topography or FVH-Alberta Stroke Program Early CT Score (ASPECTS) pattern and outcome in acute M1-middle cerebral artery occlusion patients with endovascular treatment...
November 2016: Stroke; a Journal of Cerebral Circulation
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