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https://www.readbyqxmd.com/read/29446102/phylotype-and-sequevar-of-ralstonia-solanacearum-which-causes-bacterial-wilt-in-curcuma-alismatifolia-gagnep
#1
Pornnipa Thano, Angsana Akarapisan
Bacterial wilt of Curcuma alismatifolia (Patumma) caused by Ralstonia solanacearum is a major disease affecting the quality of rhizome exports. Traditionally, R. solanacearum is classified into five races based on differences in host range and six biovars based on biochemical properties. Recently a classification scheme based on phylotypes and sequevars was presented by the scientific community as a tool for determining phylogenetic relationships within R. solanacearum. This study used traditional and molecular methods to identify R...
February 15, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29430595/the-c19s-substitution-enhances-the-stability-of-hepcidin-while-conserving-its-biological-activity
#2
Edina Pandur, Zsuzsanna Fekete, Kitti Tamási, László Grama, Edit Varga, Katalin Sipos
Hepcidin, the key hormone of iron homeostasis is responsible for lowering the serum iron level through its interaction with iron exporter ferroportin. Thus, hepcidin agonists provide a promising opportunity in the treatment of iron disorders caused by lacking or decreased hepcidin expression. We investigated the importance of each of the eight highly conserved cysteines for the biological activity of hepcidin. Eight cysteine mutants were created with site directed mutagenesis. The binding ability of these hepcidin mutants to the hepcidin receptor ferroportin was determined using bacterial two-hybrid system and WRL68 human hepatic cells...
February 12, 2018: Protein Journal
https://www.readbyqxmd.com/read/29427390/prevention-of-acute-radiodermatitis-by-photobiomodulation-a-randomized-placebo-controlled-trial-in-breast-cancer-patients-transdermis-trial
#3
Jolien Robijns, Sandrine Censabella, Stefan Claes, Luc Pannekoeke, Lore Bussé, Dora Colson, Iris Kaminski, Paul Bulens, Annelies Maes, Leen Noé, Marc Brosens, An Timmermans, Ivo Lambrichts, Veerle Somers, Jeroen Mebis
OBJECTIVE: Acute radiodermatitis (RD) is a distressing and painful skin reaction that occurs in 95% of the patients undergoing radiotherapy (RT). The aim of this study was to evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention of acute RD in breast cancer (BC) patients undergoing RT. METHODS: This study was a randomized, placebo-controlled trial including 120 BC patients that underwent an identical RT regimen post-lumpectomy. Patients were randomly assigned to the laser therapy (LT) or placebo group, with 60 patients in each group...
February 10, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29405524/genome-sequence-of-m6-a-diploid-inbred-clone-of-the-high-glycoalkaloid-producing-tuber-bearing-potato-species-solanum-chacoense-reveals-residual-heterozygosity
#4
Courtney P Leisner, John P Hamilton, Emily Crisovan, Norma C Manrique-Carpintero, Alexandre P Marand, Linsey Newton, Gina M Pham, Jiming Jiang, David S Douches, Shelley H Jansky, C Robin Buell
Cultivated potato (Solanum tuberosum L.) is a highly heterozygous autotetraploid that presents challenges in genome analyses and breeding. Wild potato species serve as a resource for the introgression of important agronomic traits into cultivated potato. One key species is Solanum chacoense and the diploid, inbred clone M6, which is self-compatible and has desirable tuber market quality and disease resistance traits. Sequencing and assembly of the genome of the M6 clone of S. chacoense generated an assembly of 825,767,562 bp in 8,260 scaffolds with an N50 scaffold size of 713,602 bp...
February 5, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29400370/high-resolution-ultrasonography-in-assessing-temporomandibular-joint-disc-position
#5
Daniel Talmaceanu, Lavinia Manuela Lenghel, Nicolae Bolog, Roxana Popa Stanila, Smaranda Buduru, Daniel Corneliu Leucuta, Horatiu Rotar, Mihaela Baciut, Grigore Baciut
AIMS: The purpose of this study was to determine the diagnostic value of high-resolution ultrasonography (US) in temporomandibular joint (TMJ) disc displacements. MATERIALS AND METHODS: A number of 74 patients (148 TMJs) with signs and symptoms of TMJ disorders, according to the Research Diagnostic Criteria for Temporomandibular Disorders, were included in this study. All patients received US and magnetic resonance imaging (MRI) of both TMJs 1 to 5 days after the clinical examination...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29397851/-prognostic-analysis-of-minimal-residual-disease-from-acute-myeloid-leukemia-after-allogeneic-hematopoietic-stem-cell-transplant-by-flow-cytometry
#6
Qi Hao, Shu-Qin Zhang, Dong-Mei Zhang, Jing-Bo Wang, Jie Zhao, Hao-Yu Cheng
OBJECTIVE: To investigate the value of flow cytometry (FCM) detection in prognostic evaluation of minimal residual disease (MRD) of acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Eighty-two cases of AML (except M3) after allo-HSCT who accord to enrolled condition (no MRD positive after allo-HSCT confirmed by regular flow cytometry detection and followed-up for 2 years) from April 2012 to September 2016 in our department were selected...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29397844/-clinical-study-of-patients-with-myelodysplastic-syndrome-transformed-into-acute-myeloid-leukemia
#7
Fang Ye, Dong-Sheng Ma, Jie Wang, Zhen-Hua Qiao
OBJECTIVE: To study the biological characteristics and treatment response of patients with myelodysplastic syndrome (MDS) transformed into acute leukemia(AL). METHODS: Using WHO standard method, the clinical characteristics of patients with MDS into AML were retrospectively analyzed, the related factors influencing the MDS into AML and the treatment response of patients were analyzed. RESULTS: Twenty-six cases (17%) of MDS were transformed into AL among 153 cases of middle and high risk MDS, all of which were AML...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29394049/unusual-and-tunable-negative-linear-compressibility-in-the-metal-organic-framework-mfm-133-m-m-zr-hf
#8
Yong Yan, Alice E O'Connor, Gopikkaa Kanthasamy, George Atkinson, David R Allan, Alexander J Blake, Martin Schröder
High pressure single-crystal X-ray structural analyses of isostructural MFM-133(M) (M = Zr, Hf) of flu topology and incorporating the tetracarboxylate ligand TCHB4- [H4TCHB = 3,3',5,5'-tetrakis(4-carboxyphenyl)-2,2',4,4',6,6'-hexamethyl-1,1'-biphenyl] and {M6(µ-OH)8(OH)8(COO)8} clusters, confirm negative linear compressibility (NLC) behavior along the c axis. This occurs via a three-dimensional wine-rack NLC mechanism leading to distortion of the octahedral cage towards a more elongated polyhedron under static compression...
February 2, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29384213/fto-reduces-mitochondria-and-promotes-hepatic-fat-accumulation-through-rna-demethylation
#9
Huifang Kang, Zhiwang Zhang, Lin Yu, Yixing Li, Mingzhen Liang, Lei Zhou
Fat mass and obesity-associated protein (FTO) is a RNA demethylase, whether FTO regulates fat metabolism through its demethylation is unclear. The results of this study confirmed that N6-methyladenosine (m6 A) is associated with fat accumulation both in vivo and in vitro. The data showed that FTO down-regulated m6 A levels, decreased mitochondrial content, and increased triglyceride (TG) deposition. However, an FTO (R316A) mutant lacking demethylation activity could not regulate mitochondria and TG content, indicating that FTO affects mitochondrial content and fat metabolism by modulating m6 A levels in hepatocytes...
January 31, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29363499/metabolic-profiling-of-the-novel-hif2%C3%AE-inhibitor-pt2385-in-vivo-and-in-vitro
#10
Cen Xie, Xiaoxia Gao, Dongxu Sun, Youbo Zhang, Kristopher W Krausz, Xuemei Qin, Frank Gonzalez
PT2385 is a first-in-class, selective small molecule inhibitor of hypoxia inducible factor-2α (HIF-2α) developed for the treatment of advanced clear cell renal cell carcinoma. Preclinical results demonstrated that PT2385 has potent anti-tumor efficacy in mouse xenograft models of kidney cancer. It also has activity toward metabolic disease in a mouse model. However, no metabolism data is currently publicly available. It is of great importance to characterize the metabolism of PT2385 and identify its effect on systemic homeostasis in mice...
January 23, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29350197/a-three-dimensional-correction-method-for-predicting-the-readings-of-a-pinpoint-chamber-on-the-cyberknife-sup-%C3%A2-sup-m6%C3%A2-machine
#11
Yongqian Zhang, Edward Brandner, Cihat Ozhasoglu, Ron Lalonde, Dwight E Heron, M Saiful Huq
The use of small fields in radiation therapy techniques has increased substantially in particular in stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT). However, as field size reduces further still, the response of the detector changes more rapidly with field size, and the effects of measurement uncertainties become increasingly significant. This work presents a novel 3D dose volume-to-point correction method to predict the readings of a 0.015cc PinPoint chamber (PTW 31014) for both small static-fields and composite-field dosimetry formed by fixed cones on the CyberKnife® M6™ machine...
January 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29343992/validation-of-bp-devices-qardioarm%C3%A2-in-the-general-population-and-omron-m6-comfort%C3%A2-in-type-ii-diabetic-patients-according-to-the-european-society-of-hypertension-international-protocol-esh-ip
#12
Mirna N Chahine, Jirar Topouchian, Parounak Zelveian, Zoya Hakobyan, Arevik Melkonyan, Alaa Azaki, Reem Diab, Aya Harb, Roland Asmar
Background: Following the European Society of Hypertension International Protocol (ESH-IP) Revision 2010, QardioArm® and Omron M6 Comfort IT® oscillometric devices were evaluated in the general population and in patients with type II diabetes, respectively, for self-blood pressure (BP) measurement. Methods: Both devices, QardioArm® and Omron M6 Comfort®, measure BP at the brachial level. The ESH-IP Revision 2010 includes a total number of 33 subjects. For each measure, the difference between observer and device BP values was calculated...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29342175/immunocontraceptive-target-repertoire-defined-by-systematic-identification-of-sperm-membrane-alloantigens-in-a-single-species
#13
Nathaly Cormier, John J McGlone, John Leszyk, Daniel M Hardy
Sperm competence in animal fertilization requires the collective activities of numerous sperm-specific proteins that are typically alloimmunogenic in females. Consequently, sperm membrane alloantigens are potential targets for contraceptives that act by blocking the proteins' functions in gamete interactions. Here we used a targeted proteomics approach to identify the major alloantigens in swine sperm membranes and lipid rafts, and thereby systematically defined the repertoire of these sperm-specific proteins in a single species...
2018: PloS One
https://www.readbyqxmd.com/read/29322941/persistent-activity-in-a-recurrent-circuit-underlies-courtship-memory-in-drosophila
#14
Xiaoliang Zhao, Daniela Lenek, Ugur Dag, Barry Dickson, Krystyna Keleman
Recurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in Drosophila relies on the recurrent circuit between mushroom body gamma (MBg), M6 output, and aSP13 dopaminergic neurons. We demonstrate persistent neuronal activity of aSP13 neurons and show that it transiently potentiates synaptic transmission from MBγ>M6 neurons. M6 neurons in turn provide input to aSP13 neurons, prolonging potentiation of MBγ>M6 synapses over time periods that match short-term memory...
January 11, 2018: ELife
https://www.readbyqxmd.com/read/29315835/fto-regulates-the-chemo-radiotherapy-resistance-of-cervical-squamous-cell-carcinoma-cscc-by-targeting-%C3%AE-catenin-through-mrna-demethylation
#15
Shun Zhou, Zhou-Lan Bai, Di Xia, Zhi-Jun Zhao, Ren Zhao, Yan-Yang Wang, Hong Zhe
The role of N6 -methyladenosine (m6 A) demethylase Fat Mass and Obesity-associated protein (FTO) in the regulation of chemo-radiotherapy resistance remains largely unknown. Here, we show that the mRNA level of FTO is elevated in cervical squamous cell carcinoma (CSCC) tissues when compared with respective adjacent normal tissues. FTO enhances the chemo-radiotherapy resistance both in vitro and in vivo through regulating expression of β-catenin by reducing m6 A levels in its mRNA transcripts and in turn increases excision repair cross-complementation group 1 (ERCC1) activity...
January 9, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29298127/association-between-loss-of-type-iv-pilus-synthesis-ability-and-phenotypic-variation-in-the-cucurbit-pathogenic-bacterium-acidovorax-citrulli
#16
Tally Rosenberg, Bolaji Babajide Salam, Saul Burdman
Acidovorax citrulli is the causal agent of bacterial fruit blotch of cucurbits. We have shown that functional type IV pili (T4P) are required for full virulence of this bacterium. To identify A. citrulli genes required for T4P activity, we screened a library of about 10,000 transposon mutants of A. citrulli strain M6 for altered T4P-mediated twitching motility. This screen led to the identification of 50 mutants impaired in twitching ability due to transposon insertions into 20 different genes. Representative mutants with disruptions in these genes were further characterized...
January 3, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29285653/continuous-subcutaneous-apomorphine-infusion-does-not-impair-the-dynamics-of-cognitive-action-control-in-mild-to-moderate-parkinson-s-disease
#17
Joan Duprez, Jean-François Houvenaghel, Sophie Drapier, Manon Auffret, Dominique Drapier, Gabriel Robert, Marc Vérin, Paul Sauleau
INTRODUCTION: Continuous subcutaneous apomorphine infusion (CSAI) is increasingly used in Parkinson's disease (PD), notably in patients contraindicated for subthalamic deep brain stimulation. Although it has been suggested that CSAI is safe regarding cognition, few studies have actually investigated its effect, especially on cognitive control which is a crucial process for goal-directed behavior. More specifically, its impact on the dynamics of cognitive action control, as reflected by the activation and suppression of impulsive responses, has yet to be investigated, which is the objective of the present study...
December 28, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29276981/comparative-metabolism-of-two-major-compounds-in-fructus-corni-extracts-by-gut-microflora-from-normal-and-chronic-nephropathy-rats-in-vitro-by-uplc-q-tof-ms
#18
Jin-Hua Tao, Min Zhao, Shu Jiang, Xue-Lian Pu, Xiao-Yan Wei
Herbal medicines are widely used as therapeutic products in many countries. Fructus Corni, a traditional herb medicine, has been clinically used to cure chronic nephropathy for thousands of years. It could be converted by gut microflora in vivo to shape its pharmacological profiles. Thus, metabolic profiles of major active constituents in Fructus Corni extracts by gut microflora from rats in healthy and nephropathy state were firstly investigated in vitro by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) in this study...
December 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29273084/identification-of-cryptolepine-metabolites-in-rat-and-human-hepatocytes-and-metabolism-and-pharmacokinetics-of-cryptolepine-in-sprague-dawley-rats
#19
Arnold Donkor Forkuo, Charles Ansah, David Pearson, Werner Gertsch, Amanda Cirello, Adam Amaral, Jaimie Spear, Colin W Wright, Caroline Rynn
BACKGROUND: This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male Sprague Dawley (SD) rats. METHODS: The in vitro metabolic profiles of cryptolepine were determined by LC-MS/MS following incubation with rat and human hepatocytes. The in vivo metabolic profile of cryptolepine was determined in plasma and urine samples from Sprague Dawley rats following single-dose oral administration of cryptolepine...
December 22, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29230462/synthesis-of-m-uio-66-m-zr-ce-or-hf-employing-2-5-pyridinedicarboxylic-acid-as-a-linker-defect-chemistry-framework-hydrophilisation-and-sorption-properties
#20
S Waitschat, D Fröhlich, H Reinsch, H Terraschke, K A Lomachenko, C Lamberti, H Kummer, T Helling, M Baumgartner, S Henninger, N Stock
Metal-organic frameworks of general composition [M6(OH)4(O)4(PDC)6-x(Cl)2x(H2O)2x] with M = Zr, Ce, Hf; PDC2- = 2,5-pyridinedicarboxylate and 0 ≤ x ≤ 2 were obtained under reflux using formic, nitric or acetic acid as an additive. Rietveld refinements carried out using a fixed occupancy of the linker molecules according to the results of thermogravimetric measurements confirmed that the MOFs crystallize in the UiO-66 type structure and demonstrate that the structural models describe the data well. Further characterization was carried out by NMR spectroscopy, thermogravimetric analysis, Zr K-edge EXAFS- and Ce L3-edge XANES measurements...
December 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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