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https://www.readbyqxmd.com/read/29230462/synthesis-of-m-uio-66-m-zr-ce-or-hf-employing-2-5-pyridinedicarboxylic-acid-as-a-linker-defect-chemistry-framework-hydrophilisation-and-sorption-properties
#1
S Waitschat, D Fröhlich, H Reinsch, H Terraschke, K A Lomachenko, C Lamberti, H Kummer, T Helling, M Baumgartner, S Henninger, N Stock
Metal-organic frameworks of general composition [M6(OH)4(O)4(PDC)6-x(Cl)2x(H2O)2x] with M = Zr, Ce, Hf; PDC2- = 2,5-pyridinedicarboxylate and 0 ≤ x ≤ 2 were obtained under reflux using formic, nitric or acetic acid as an additive. Rietveld refinements carried out using a fixed occupancy of the linker molecules according to the results of thermogravimetric measurements confirmed that the MOFs crystallize in the UiO-66 type structure and demonstrate that the structural models describe the data well. Further characterization was carried out by NMR spectroscopy, thermogravimetric analysis, Zr K-edge EXAFS- and Ce L3-edge XANES measurements...
December 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29219176/tet2-expression-is-a-potential-prognostic-and-predictive-biomarker-in-cytogenetically-normal-acute-myeloid-leukemia
#2
Ting-Juan Zhang, Jing-Dong Zhou, Dong-Qin Yang, Yu-Xin Wang, Xiang-Mei Wen, Hong Guo, Lei Yang, Xin-Yue Lian, Jiang Lin, Jun Qian
TET2 (Ten-Eleven Translocation 2) gene is a member of TET family that can modify DNA through catalyzing the conversion of 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC). Although TET2 mutation has been disclosed in a variety of hematopoietic malignancies, the prognostic implication of TET2 expression in acute myeloid leukemia (AML) remains largely elusive. In this study, real-time quantitative PCR was carried out to detect the level of TET2 transcript in 134 de novo AML patients and 35 healthy donors...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29205437/mrna-traffic-control-reviewed-n6-methyladenosine-m6-a-takes-the-driver-s-seat
#3
REVIEW
Abhirami Visvanathan, Kumaravel Somasundaram
Messenger RNA is a flexible tool box that plays a key role in the dynamic regulation of gene expression. RNA modifications variegate the message conveyed by the mRNA. Similar to DNA and histone modifications, mRNA modifications are reversible and play a key role in the regulation of molecular events. Our understanding about the landscape of RNA modifications is still rudimentary in contrast to DNA and histone modifications. The major obstacle has been the lack of sensitive detection methods since they are non-editing events...
December 4, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29194431/characteristics-of-plantar-loads-during-walking-in-patients-with-knee-osteoarthritis
#4
Zhiwang Zhang, Lin Wang, Kaijun Hu, Yu Liu
BACKGROUND Knee osteoarthritis (KOA) is a common disease that can change the load on lower limbs during walking. Plantar loads in patients with KOA may provide a basis for clinical decisions regarding footwear and foot orthoses. This study aimed to compare plantar loads in females with and without KOA during gait. MATERIAL AND METHODS Plantar pressure during walking was recorded in 23 females with KOA and 23 females without KOA. Maximum force (MF), contact area (CA), and peak pressure (PP) were measured at 7 different regions underneath the foot, named heel (M1), midfoot (M2), first metatarsophalangeal joint (MPJ) (M3), second MPJ (M4), third to fifth MPJ (M5), hallux (M6), and lesser toes (M7)...
December 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29192384/spin-states-of-mn-iii-meso-tetraphenylporphyrin-chloride-assessed-by-density-functional-methods
#5
Higo de Lima Bezerra Cavalcanti, Gerd Bruno Rocha
The present work assessed several exchange-correlation functionals (including GGA, meta-GGA and hybrid functionals), in combination with a variety of basis sets and effective core potentials (ECP) for their ability to predict the ground spin state of Mn(III) meso-tetraphenylporphyrin chloride complex, labeled Mn(III)TPPCl, for which experimental data support the quintet high spin state. Geometry optimization of Mn(III)TPPCl was performed for three possible spin states (singlet state, LS; triplet state, IS; and quintet state, HS) at the TPSSh level using the LANL2DZ ECP for Mn and the 6-311G(d) basis set for C, N, Cl and H...
November 30, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29181139/outcome-of-frontline-treatment-with-generic-imatinib-in-adult-patients-with-chronic-myeloid-leukemia-in-algerian-population-a-multicenter-study
#6
B Entasoltan, M A Bekadja, H Touhami, N Mehalhal, Z Zouaoui, N Mesli, M Talbi, A Bachiri, M Michallet
Introduction: In a developing country like Algeria, such expensive therapy is not available. Alternative approaches are needed to help these adult. In Algeria 'imatib' (CIPLA-India) was introduced in 2006; but no study has been published yet in the North Africa region regarding response and outcome of this copy in CML patients. The goal of this multicenter study is to characterize newly adult CML in the western region of Algeria and to assess the effectiveness and safety of imatib (IM, copy) as frontline therapy for patients with CML...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29180062/metabolic-detoxification-of-bakuchiol-is-mediated-by-oxidation-of-cyp-450s-in-liver-microsomes
#7
Xiao-Jing Hu, You-Bo Zhang, Zi-Jing Zhao, Lei Zhang, Qi Wang, Xiu-Wei Yang
Bakuchiol, one of bioactive compounds isolated from the dried ripe fruits of Psoralea corylifolia L., possesses a variety of pharmacological activities. In this study, the metabolites of bakuchiol in rat liver microsomes as well as their cytotoxicities were studied. A total of eight metabolites were isolated and identified as 14-carboxylbakuchiol (M1), 14,15-dihydroxybakuchiol (M2), 12,13-dihydroxybakuchiol (M3), 15-hydroxybakuchiol (M4), 14-hydroxybakuchiol (M5), bakuchiol hydrate (M6), 15-hydroxybakuchiol acetate (M7), and 14-hydroxybakuchiol acetate (M8)...
November 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29171020/clopidogrel-but-not-prasugrel-significantly-inhibits-the-cyp2c8-mediated-metabolism-of-montelukast-in-humans
#8
M K Itkonen, A Tornio, A M Filppula, M Neuvonen, P J Neuvonen, M Niemi, J T Backman
The oxidation of montelukast is mainly mediated by cytochrome P450 (CYP) 2C8, but other mechanisms may contribute to its disposition. In healthy volunteers, we investigated the effects of two widely used P2Y12 inhibitors on montelukast pharmacokinetics. Clopidogrel (300 mg on day 1 and 75 mg on day 2) increased the area under the plasma concentration-time curve (AUC) of montelukast 2.0-fold (90% CI 1.72-2.28, P < 0.001) and decreased the M6:montelukast AUC0-7h ratio to 45% of control (90% CI 40-50%, P < 0...
November 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29170397/methylomic-and-phenotypic-analysis-of-the-modh5-phasevarion-of-helicobacter-pylori
#9
Yogitha N Srikhanta, Rebecca J Gorrell, Peter M Power, Kirill Tsyganov, Matthew Boitano, Tyson A Clark, Jonas Korlach, Elizabeth L Hartland, Michael P Jennings, Terry Kwok
The Helicobacter pylori phase variable gene modH, typified by gene HP1522 in strain 26695, encodes a N(6)-adenosine type III DNA methyltransferase. Our previous studies identified multiple strain-specific modH variants (modH1 - modH19) and showed that phase variation of modH5 in H. pylori P12 influenced expression of motility-associated genes and outer membrane protein gene hopG. However, the ModH5 DNA recognition motif and the mechanism by which ModH5 controls gene expression were unknown. Here, using comparative single molecule real-time sequencing, we identify the DNA site methylated by ModH5 as 5'-G(m6)ACC-3'...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29157132/in-planta-functions-of-cytochrome-p450-monooxygenase-genes-in-the-phytocassane-biosynthetic-gene-cluster-on-rice-chromosome-2
#10
Zhongfeng Ye, Kohei Yamazaki, Hiromi Minoda, Koji Miyamoto, Sho Miyazaki, Hiroshi Kawaide, Arata Yajima, Hideaki Nojiri, Hisakazu Yamane, Kazunori Okada
In response to environmental stressors such as blast fungal infections, rice produces phytoalexins, an antimicrobial diterpenoid compound. Together with momilactones, phytocassanes are among the major diterpenoid phytoalexins. The biosynthetic genes of diterpenoid phytoalexin are organized on the chromosome in functional gene clusters, comprising diterpene cyclase, dehydrogenase, and cytochrome P450 monooxygenase genes. Their functions have been studied extensively using in vitro enzyme assay systems. Specifically, P450 genes (CYP71Z6, Z7; CYP76M5, M6, M7, M8) on rice chromosome 2 have multifunctional activities associated with ent-copalyl diphosphate-related diterpene hydrocarbons, but the in planta contribution of these genes to diterpenoid phytoalexin production remains unknown...
November 20, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29136555/non-targeted-metabolomics-guided-sildenafil-metabolism-study-in-human-liver-microsomes
#11
Ju-Hyun Kim, Jun Hyun Jo, Kyung-Ah Seo, Hayoung Hwang, Hye Suk Lee, Sangkyu Lee
Metabolomics combined with high-resolution mass spectrometry (HR-MS) and multivariate data analysis has broad applications in the study of xenobiotic metabolism. Although information about xenobiotic metabolism is essential to understand toxic mechanisms, pharmacokinetic parameters and excretion pathways, it is limited to predict all generated metabolites in biological fluids. Here, we revisited sildenafil metabolism in human liver microsomes using a metabolomics approach to achieve a global picture of sildenafil phase 1 metabolism...
November 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29130636/efficacy-of-subcutaneous-injection-of-platelet-rich-plasma-in-alopecia-a-clinical-and-histological-pilot-study-on-a-rat-model-with-a-six-month-long-term-follow-up-experience
#12
Sophie Orliac, Jean-Michel Serfaty, Anne Perozziello, Olivier Zurlinden, Liliane Louedec, Benjamin Dallaudière
PURPOSE: To assess the potential of platelet-rich plasma (PRP) subcutaneous injection of to treat alopecia and to evaluate local toxicity. MATERIALS-METHODS: Twelve Hairless rats were used. At D0, we performed systematic clinical examination and divided the rat back into four quadrants (Q). We initiated subcutaneous injection using either PRP in PRPQ+, platelet-poor plasma (PPP) in PPPQ+, physiological serum (PS) in PSQ+, or no treatment (Q4). At D7, D14, D21, and D28 but also second month (M2), M3, M4, M5, rats had exactly the same injection procedure...
November 11, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29128830/metabolism-of-the-synthetic-cannabinoid-5f-py-pica-by-human-and-rat-hepatocytes-and-identification-of-biliary-analytical-targets-by-directional-efflux-in-sandwich-cultured-rat-hepatocytes-using-uhplc-hr-ms-ms
#13
Marie Mardal, Pieter Annaert, Carolina Noble, Marlies Oorts, Kristian Linnet
Analytical strategies for detecting drugs in biological samples rely on information on metabolism and elimination. 5F-PY-PICA belongs to the group of synthetic cannabinoids that are known to undergo excretion into the bile. The aims of this study were the in vitro identification of metabolites of 5F-PY-PICA and to determine which analytical targets are excreted into the bile and urine. Metabolites identified after incubation of 5F-PY-PICA with pooled human liver microsomes (pHLM), pooled human hepatocytes (pHH), or suspended and sandwich-cultured rat hepatocytes (SCRH)...
November 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29125234/evaluation-of-clinically-applied-treatment-beams-with-respect-to-bunker-shielding-parameters-for-a-cyberknife-m6
#14
Dominik Henzen, Daniel Schmidhalter, Claudia Christina Zanella, Werner Volken, Paul-Henry Mackeprang, Marco Malthaner, Michael Karl Fix, Peter Manser
Compared to a conventional linear accelerator, the Cyberknife (CK) is a unique system with respect to radiation protection shielding and the variety and number of non-coplanar beams are two key components regarding this aspect. In this work, a framework to assess the direction distribution and modulation factor (MF) of clinically applied treatment beams of a CyberKnife M6 is developed. Database filtering options allow studying the influence of different parameters such as collimator types, treatment sites or different bunker sizes...
November 10, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29116043/two-receptor-tyrosine-phosphatases-dictate-the-depth-of-axonal-stabilizing-layer-in-the-visual-system
#15
Satoko Hakeda-Suzuki, Hiroki Takechi, Hinata Kawamura, Takashi Suzuki
Formation of a functional neuronal network requires not only precise target recognition, but also stabilization of axonal contacts within their appropriate synaptic layers. Little is known about the molecular mechanisms underlying the stabilization of axonal connections after reaching their specifically targeted layers. Here, we show that two receptor protein tyrosine phosphatases (RPTPs), LAR and Ptp69D, act redundantly in photoreceptor afferents to stabilize axonal connections to the specific layers of the Drosophila visual system...
November 8, 2017: ELife
https://www.readbyqxmd.com/read/29094793/encapsulation-of-a-quinhydrone-cofactor-in-the-inner-pocket-of-cobalt-triangular-prisms-combined-light-driven-reduction-of-protons-and-hydrogenation-of-nitrobenzene
#16
Liang Zhao, Jianwei Wei, Jing Zhang, Cheng He, Chunying Duan
The design of artificial systems that mimic highly evolved and finely tuned natural photosynthetic systems has attracted intensive research interest. A new system was formulated that encapsulates a quinhydrone (QHQ) cofactor in metal-organic hosts based on inspiration from the redox relays of photosystem II. The M6 L3 triangular prism hosts provided a special redox-modulated environment for the cofactor localized within the pocket, and the proximity effects of the host-guest interactions facilitated the formation of charge-transfer complexes that are typically very difficult to form in normal homogeneous systems...
November 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29076467/-analysis-of-the-results-of-total-cervical-disc-arthroplasty-using-a-m6-c-prosthesis-a-multicenter-study
#17
V A Byval'tsev, A A Kalinin, I A Stepanov, Yu Ya Pestryakov, V V Shepelev
Cervical spondylosis and intervertebral disc (IVD) degeneration are the most common cause for compression of the spinal cord and/or its roots. Total IVD arthroplasty, as a modern alternative to surgical treatment of IVD degeneration, is gaining popularity in many neurosurgical clinics around the world. Aim - the study aim was to conduct a multicenter analysis of cervical spine arthroplasty with an IVD prosthesis M6-C ('Spinal Kinetics', USA). MATERIAL AND METHODS: The study included 112 patients (77 males and 35 females)...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29067789/the-new-acetylcholinesterase-inhibitors-pc-37-and-pc-48-7-meota-donepezil-like-compounds-characterization-of-their-metabolites-in-human-liver-microsomes-pharmacokinetics-and-in-vivo-formation-of-the-major-metabolites-in-rats
#18
Jana Zdarova Karasova, Martin Mzik, Milos Hroch, Jan Korabecny, Eugenie Nepovimova, Viktor Vorisek, Vladimir Palicka, Kamil Kuca
The objective of this study was to elucidate the pharmacokinetics and metabolite formation of newly developed non-selective AChE/BChE 7-MEOTA-donepezil-like inhibitors for potential therapeutic use in Alzheimer disease patients. The chemical structures of metabolites were defined during incubation with human liver microsomes, and subsequently the metabolization was verified in in vivo study. In vitro metabolic profiling revealed the formation of nine major metabolites in the case of PC-37 and eight metabolites of PC-48...
October 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29029143/genome-wide-analysis-of-genetic-risk-factors-for-rheumatic-heart-disease-in-aboriginal-australians-provides-support-for-pathogenic-molecular-mimicry
#19
Lesley-Ann Gray, Heather A D'Antoine, Steven Y C Tong, Melita McKinnon, Dawn Bessarab, Ngaire Brown, Bo Reményi, Andrew Steer, Genevieve Syn, Jenefer M Blackwell, Michael Inouye, Jonathan R Carapetis
Background: Rheumatic heart disease (RHD) following Group A Streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers pro-inflammatory cardiac valve-reactive T-cells. Methods: Genome-wide genetic analysis was undertaken in 1263 Aboriginal Australians (398 RHD cases; 865 controls). Single nucleotide polymorphisms (SNPs) were genotyped using Illumina HumanCoreExome BeadChips. Direct typing and imputation was used to fine-map the human leukocyte antigen (HLA) region...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028843/efficiency-of-different-air-filter-types-for-pig-facilities-at-laboratory-scale
#20
Cindy Wenke, Janina Pospiech, Tobias Reutter, Uwe Truyen, Stephanie Speck
Air filtration has been shown to be efficient in reducing pathogen burden in circulating air. We determined at laboratory scale the retention efficiency of different air filter types either composed of a prefilter (EU class G4) and a secondary fiberglass filter (EU class F9) or consisting of a filter mat (EU class M6 and F8-9). Four filter prototypes were tested for their capability to remove aerosol containing equine arteritis virus (EAV), porcine reproductive and respiratory syndrome virus (PRRSV), bovine enterovirus 1 (BEV), Actinobacillus pleuropneumoniae (APP), and Staphylococcus (S...
2017: PloS One
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