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https://www.readbyqxmd.com/read/28069281/-effect-of-donor-graft-characteristics-on-clinical-outcomes-in-descemet-stripping-automated-endothelial-keratoplasty-dsaek
#1
G Ho Wang Yin, M Sampo, S Soare, L Hoffart
INTRODUCTION: The purpose of our study was to evaluate the progression of lamellar corneal grafts after endothelial keratoplasty by Descemet stripping automated endothelial keratoplasty (DSAEK) and the effect of their characteristics on the clinical and functional results. MATERIALS AND METHODS: This was a prospective study in which 74 patients who had undergone endothelial keratoplasty by DSAEK were included. The corneal grafts were obtained from a French tissue bank and were delivered in a preservation medium containing a deturgescent agent (Corneajet(®) or Stemalpha 3(®))...
January 6, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28069114/soymilk-enriched-with-green-coffee-phenolics-antioxidant-and-nutritional-properties-in-the-light-of-phenolics-food-matrix-interactions
#2
Łukasz Sęczyk, Michał Świeca, Urszula Gawlik-Dziki
This study investigated the effect of soymilk fortification with green coffee extract (GCE) on phenolic contents, antioxidant capacity, relative in vitro digestibility of proteins and starch, and consumer acceptance. Special attention was paid to the effect of phenolics-food matrix interactions on fortification efficiency. Soymilk was enriched with GCE extracts containing 0.025-1mg of phenolics per 1mL-samples M1-M6. Compared to control, an increase in phenolic contents of up to 70% (M6) was observed for potentially bioaccessible fractions (AD)...
May 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28054362/the-6-minute-mastication-test-a-unique-test-to-assess-endurance-of-continuous-chewing-normal-values-reliability-reproducibility-and-usability-in-patients-with-mitochondrial-disease
#3
Lenie van den Engel-Hoek, Simone Knuijt, Marjo van Gerven, Marloes Lagarde, Jan T Groothuis, Imelda J M de Groot, Mirian C H Janssen
In patients with mitochondrial disease, fatigue and muscle problems are the most common complaints. They also experience these complaints during mastication. To measure endurance in continuous mastication in patients with mitochondrial diseases the 6-minute mastication test (6MMT) was developed. This study included the collection of normal data for the 6MMT in a healthy population (children and adults). During 6 minutes of continuous mastication on a chew tube chewing cycles per minute, total amount of chewing cycles and the difference between minute 1 (M1 ) and minute 6 (M2 ) were collected in 271 healthy participants (5 - 80 years old)...
January 5, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28052366/impact-of-fab-classification-on-predicting-outcome-in-acute-myeloid-leukemia-not-otherwise-specified-patients-undergoing-allogeneic-stem-cell-transplantation-in-cr1-an-analysis-of-1690-patients-from-the-acute-leukemia-working-party-of-ebmt
#4
Jonathan Canaani, Eric Beohou, Myriam Labopin, Gerard Socié, Anne Huynh, Liisa Volin, Jan Cornelissen, Noel Milpied, Tobias Gedde-Dahl, Eric Deconinck, Nathalie Fegueux, Didier Blaise, Mohamad Mohty, Arnon Nagler
The French, American, and British (FAB) classification system for acute myeloid leukemia (AML) is extensively used and is incorporated into the AML, not otherwise specified (NOS) category in the 2016 WHO edition of myeloid neoplasm classification. While recent data proposes that FAB classification does not provide additional prognostic information for patients for whom NPM1 status is available, it is unknown whether FAB still retains a current prognostic role in predicting outcome of AML patients undergoing allogeneic stem cell transplantation...
January 4, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28048550/su-f-t-481-physics-evaluation-of-a-newly-released-incise%C3%A2-multileaf-collimator-for-cyberknife-m6%C3%A2-system
#5
L Wang, E Chin, A Lo
PURPOSE: This work reports the results of the physics evaluation of a newly released InCise™2 Multileaf Collimator (MLC) installed in our institution. METHODS: Beam property data was measured with unshielded diode and EBT2 films. The measurements included MLC leaf transmission, beam profiles, output factors and tissue-phantom ratios. MLC performance was evaluated for one month after commissioning. Weekly Garden Fence tests were performed for leaf / bank positioning in standard (A/P) and clinically relevant non-standard positions, before and after MLC driving exercises of 10+ minutes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048418/su-f-sps-10-the-dosimetric-comparison-of-gammaknife-and-cyberknife-treatment-plans-for-brain-srs-treatment
#6
E Sanli, H Mabhouti, M Cebe, G Codel, P Pacaci, E Serin, N Kucuk, E Kucukmorkoc, M Doyuran, D Canoglu, A Altinok, H Acar, H Caglar Ozkok
PURPOSE: Brain stereotactic radiosurgery (SRS) involves the use of precisely directed, single session radiation to create a desired radiobiologic response within the brain target with acceptable minimal effects on surrounding structures or tissues. In this study, the dosimetric comparison of GammaKnife perfection and Cyberknife M6 treatment plans were made. METHODS: Treatment plannings were done for GammaKnife perfection unit using Gammaplan treatment planning system (TPS) on the CT scan of head and neck randophantom simulating the treatment of sterotactic treatments for one brain metastasis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048315/su-f-t-650-the-comparison-of-robotic-partial-breast-stereotactic-irradiation-using-mlc-vs-iris-cone
#7
C Ding, R Timmerman, S Jiang, A Rahimi
PURPOSE: To evaluate the dosimetric impact on treatment planning for partial breast stereotactic irradiation using Cyberknife with MLC versus Iris Cone. METHODS: Ten patients whom underwent lumpectomy for DCIS or stage I invasive non-lobular epithelial breast cancer were included in this study. All patients were previously treated on the Cyberknife using Iris cone with the prescription dose of 37.5Gy in 5 fractions covering at least 95% of PTV on our phase I SBRT 5 fraction partial breast irradiation trial...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047770/su-f-sps-11-the-dosimetric-comparison-of-truebeam-2-0-and-cyberknife-m6-treatment-plans-for-brain-srs-treatment
#8
H Mabhouti, E Sanli, M Cebe, G Codel, P Pacaci, E Serin, N Kucuk, E Kucukmorkoc, M Doyuran, D Canoglu, A Altinok, H Acar, H Caglar Ozkok
PURPOSE: Brain stereotactic radiosurgery involves the use of precisely directed, single session radiation to create a desired radiobiologic response within the brain target with acceptable minimal effects on surrounding structures or tissues. In this study, the dosimetric comparison of Truebeam 2.0 and Cyberknife M6 treatment plans were made. METHODS: For Truebeam 2.0 machine, treatment planning were done using 2 full arc VMAT technique with 6 FFF beam on the CT scan of Randophantom simulating the treatment of sterotactic treatments for one brain metastasis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046425/su-f-sps-02-accuracy-of-the-small-field-dosimetry-using-the-monte-carlo-and-sequential-dose-calculation-algorithms-of-multiplan-treatment-planning-system-within-and-beyond-heterogeneous-media-for-cyberknife-m6-unit
#9
E Serin, G Codel, H Mabhouti, M Cebe, E Sanli, P Pacaci, N Kucuk, E Kucukmorkoc, M Doyuran, D Canoglu, A Altinok, H Acar, H Caglar Ozkok
PURPOSE: In small field geometries, the electronic equilibrium can be lost, making it challenging for the dose-calculation algorithm to accurately predict the dose, especially in the presence of tissue heterogeneities. In this study, dosimetric accuracy of Monte Carlo (MC) advanced dose calculation and sequential algorithms of Multiplan treatment planning system were investigated for small radiation fields incident on homogeneous and heterogeneous geometries. METHODS: Small open fields of fixed cones of Cyberknife M6 unit 100 to 500 mm2 were used for this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046415/th-ab-201-05-determining-the-direction-distribution-of-the-primary-radiation-for-a-cyberknife-m6
#10
D Henzen, C C Zanella, D Schmidhalter, W Volken, P-H Mackeprang, M Malthaner, M K Fix, P Manser
PURPOSE: Radiation protection regulatory differentiates between primary and scatter radiation. Whereas for conventional clinical linear accelerators the solid angle for primary radiation is planar, the Cyberknife (Accuray Inc., Sunnyvale, CA) may point its beam in all spatial directions. In order to be able to judge on radiation protection calculations for a Cyberknife-M6 vault, the direction distribution for delivered plans was evaluated based on clinical experiences. METHODS: The log-files of 121 delivered patient treatment plans were exported, divided into cranial and extra-cranial treatments and the delivered monitor units (MU) together with the corresponding beam directions were analyzed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046273/su-f-t-586-pre-treatment-qa-of-incise2-mlc-plans-on-a-cyberknife-m6-using-the-delta4-system-in-sbrt
#11
D Schmidhalter, D Henzen, M Malthaner, D Frauchiger, M K Fix, P Manser
PURPOSE: Performing pre-treatment quality assurance (QA) with the Delta4 system (ScandiDos Inc., Madison, WI) is well established for linac-based radiotherapy. This is not true when using a Cyberknife (Accuray Inc., Sunnyvale, CA) where, typically film-based QA is applied. The goal of this work was to test the feasibility to use the Delta4 system for pre-treatment QA for stereotactic body radiation therapy (SBRT) using a Cyberknife-M6 equipped with the InCise2 multileaf collimator (MLC)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046263/su-f-t-620-development-of-a-convolution-superposition-dose-engine-for-cyberknife-system
#12
Y Li, B Liu, T Song, S Xu, J Piao, B Liang, X Xu, B Guo, R Wei, F Zhou
PURPOSE: Current CyberKnife treatment planning system (TPS) provided two dose calculation algorithms: Ray-tracing and Monte Carlo. Ray-tracing algorithm is fast, but less accurate, and also can't handle irregular fields since a multi-leaf collimator system was recently introduced to CyberKnife M6 system. Monte Carlo method has well-known accuracy, but the current version still takes a long time to finish dose calculations. The purpose of this paper is to develop a GPU-based fast C/S dose engine for CyberKnife system to achieve both accuracy and efficiency...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046262/we-de-bra-11-a-study-of-motion-tracking-accuracy-of-robotic-radiosurgery-using-a-novel-ccd-camera-based-end-to-end-test-system
#13
L Wang, B Nelson, Y M Yang
PURPOSE: A novel end-to-end test system using a CCD camera and a scintillator based phantom (XRV-124, Logos Systems Int'l) capable of measuring the beam-by-beam delivery accuracy of Robotic Radiosurgery (CyberKnife) was developed and reported in our previous work. This work investigates its application in assessing the motion tracking (Synchrony) accuracy for CyberKnife. METHODS: A QA plan with Anterior and Lateral beams (with 4 different collimator sizes) was created (Multiplan v5...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042722/m6-c-artificial-disc-placement
#14
Domagoj Coric, John Parish, Margaret O Boltes
There has been a steady evolution of cervical total disc replacement (TDR) devices over the last decade resulting in surgical technique that closely mimics anterior cervical discectomy and fusion as well as disc design that emphasizes quality of motion. The M6-C TDR device is a modern-generation artificial disc composed of titanium endplates with tri-keel fixation as well as a polyethylene weave with a polyurethane core. Although not yet approved by the FDA, M6-C has finished a pilot and pivotal US Investigational Device Exemption (IDE) study...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28042052/cognitive-changes-under-memantine-according-to-vitamin-d-status-in-alzheimer-patients-an-exposed-unexposed-cohort-pilot-study
#15
REVIEW
Pauline Lemire, Antoine Brangier, Melinda Beaudenon, Guillaume T Duval, Cedric Annweiler
Memantine is a symptomatic treatment that partially prevents cognitive decline in Alzheimer disease (AD). The neuroprotective effects of memantine and vitamin D may potentiate each other, with benefits for cognition. The objective of this exposed/unexposed pilot study was to determine the cognitive changes among AD patients using memantine according to the presence or absence of vitamin D deficiency (VDD). Fifty-eight AD patients followed in a memory clinic during 6 months between 2009 and 2014 (mean±standard deviation, 82...
December 29, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28033110/monte-carlo-simulated-corrections-for-beam-commissioning-measurements-with-circular-and-mlc-shaped-fields-on-the-cyberknife-m6-system-a-study-including-diode-microchamber-point-scintillator-and-synthetic-microdiamond-detectors
#16
Paolo Francescon, Warren Kilby, John Noll, Laura Masi, Ninfa Satariano, Serenella Russo
Monte Carlo simulation was used to calculate correction factors for output factor (OF), percentage depth-dose (PDD), and off-axis ratio (OAR) measurements with the CyberKnife M6 system. These include the first such data for the InCise MLC. Simulated detectors include diodes, air-filled microchambers, a synthetic microdiamond detector, and point scintillator. Individual perturbation factors were also evaluated. OF corrections show similar trends to previous studies. With a 5mm fixed collimator the diode correction to convert a measured OF to the corresponding point dose ratio varies between -6...
December 29, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27998465/-clinical-utility-of-real-time-fluorescent-pcr-for-combined-detection-of-anaplastic-lymphoma-kinase-and-c-ros-oncogene-1-receptor-tyrosine-kinase-in-non-small-cell-lung-cancer
#17
D Y Bai, H P Zhang, S Zhong, W H Suo, D H Gao, Y Ding, J H Tu
Objective: To investigate the clinical application value of combined detection of ALK fusion gene and c-ros oncogene 1 receptor tyrosine kinase (ROS1) fusion gene in non-small cell lung cancer (NSCLC) using real-time fluorescent PCR. Methods: A kit for combined detection of ALK fusion gene and ROS1 fusion gene based on fluorescent PCR was used to simultaneously detect the two fusion genes in 302 cases of NSCLC specimens. The results were validated through Sanger sequencing. The consistency of the two detection methods was analyzed...
December 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27995876/-evi1-expression-clinical-and-cytogenetical-characteristics-in-447-patients-with-acute-myeloid-leukemia
#18
X F He, Q R Wang, J N Cen, H Y Qiu, A N Sun, S N Chen, D P Wu
Objective: To investigate EVI1 expression and its associated clinical and cytogenetic characteristics in 447 acute myeloid leukemia (AML) patients. Methods: EVI1 expressions were measured in 447 AML cases from Jan. 2007 to Apr. 2015 to couple with clinical, cytogenetic and mutations' characteristics to summarize the features of AMLs with high EVI1 expression. Results: 17.9% of AML were high EVI1 expression (EVI1 (+)), and the remainder low EVI1 expression (EVI1(-)). No significant differences between the two groups in terms of age, sex, hemoglobin level, white blood cell count and platelet count were observed...
November 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27989712/assessment-of-zygomatic-bone-using-cone-beam-computed-tomography-in-a-turkish-population
#19
Kıvanç Kamburoğlu, Burcu Kirşan Büyükkoçak, Buket Acar, Candan Semra Paksoy
OBJECTIVE: To provide linear and volumetric measurements of zygomatic bone using cone beam computed tomography (CBCT) images. STUDY DESIGN: CBCT images were assessed for 198 patients. Posterior and anterior zygomatic bone widths (M1 and M2), zygomatic bone projection (M3), zygomatic bone height (M4), combined zygomatic arch diameter (M5), maximum cortical thickness (M6), gray value obtained from maximum cortical thickness region (M7), minimum cortical thickness (M8), and gray value obtained from minimum cortical thickness region (M9) were measured...
November 2, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27989148/chemical-reactivity-of-emodin-and-its-oxidative-metabolites-to-thiols
#20
Boyang Qin, Yang Xu, Jiaming Chen, Wenlin Huang, Ying Peng, Jiang Zheng
Polygonum multiflorum is an herbal medicine widely employed in China. Hepatotoxicity of the herbal medicine has been well documented, but the mechanisms of the toxicity remain unknown. Emodin (EM) is a major constituent of the herb and has been reported to be hepatotoxic. The main purpose of this study was to define the metabolic pathways of EM in order to characterize the potential reactive intermediates. EM was incubated with rat liver microsomes or human liver microsomes, followed by LC-MS/MS analysis to investigate the in vitro and in vivo metabolism of EM...
December 19, 2016: Chemical Research in Toxicology
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