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https://www.readbyqxmd.com/read/28515938/accounting-for-adjuvant-induced-artifacts-in-the-characterization-of-vaccine-formulations-by-polyacrylamide-gel-electrophoresis
#1
Virginie Jakob, Livia Brunner, Christophe Barnier-Quer, Molly Blust, Nicolas Collin, Lauren Carter, Darrick Carter, Kelly M Rausch, Christopher B Fox
OBJECTIVES: Several vaccine adjuvants comprise complex nano- or micro-particle formulations, such as oil-in-water emulsions. In order to characterize interactions and compatibility of oil-in-water emulsion adjuvants with protein antigens in vaccines, effective protein characterization methods that can accommodate potential interference from high concentrations of lipid-based particles are needed. METHODS: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is a standard protein characterization technique which is affected by the presence of adjuvants such as oil-in-water emulsions...
April 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28514895/outcomes-after-use-of-aortouniiliac-endoprosthesis-versus-modular-or-unibody-bifurcated-endoprostheses-for-endovascular-repair-of-ruptured-abdominal-aortic-aneurysms
#2
Prateek K Gupta, Kelly Kempe, Reshma Brahmbhatt, Himani Gupta, Jorge Montes, R Armour Forse, Shaun M Stickley, Michael J Rohrer
OBJECTIVES: Outcomes after endovascular repair (EVAR) of ruptured abdominal aortic aneurysms (rAAAs) have been widely published. There is, however, controversy on the role of the use of aortouniiliac endoprosthesis (AUI) versus modular or unibody bifurcated endoprosthesis (MUB) for repair of rAAAs. We study and compare 30-day outcomes after use of AUI and MUB for all rAAAs focusing specifically on patients with instability. MATERIALS AND METHODS: Patients who underwent EVAR for rAAA (n = 425) using AUI (n = 55; 12...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28514670/radiation-safety-in-children-with-congenital-and-acquired-heart-disease-a-scientific-position-statement-on-multimodality-dose-optimization-from-the-image-gently-alliance
#3
REVIEW
Kevin D Hill, Donald P Frush, B Kelly Han, Brian G Abbott, Aimee K Armstrong, Robert A DeKemp, Andrew C Glatz, S Bruce Greenberg, Alexander Sheldon Herbert, Henri Justino, Douglas Mah, Mahadevappa Mahesh, Cynthia K Rigsby, Timothy C Slesnick, Keith J Strauss, Sigal Trattner, Mohan N Viswanathan, Andrew J Einstein
There is a need for consensus recommendations for ionizing radiation dose optimization during multi-modality medical imaging in children with congenital and acquired heart disease (CAHD). These children often have complex diseases and may be exposed to a relatively high cumulative burden of ionizing radiation from medical imaging procedures including cardiac computed tomography, nuclear cardiology studies and fluoroscopically guided diagnostic and interventional catheterization and electrophysiology procedures...
May 17, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28496387/frontal-sinus-fractures
#4
REVIEW
Kelly Schultz, Tara L Braun, Tuan A Truong
The frontal bone serves a protective role, representing the transition between the facial skeleton and the cranium. Within its enclosure, the frontal sinus lies adjacent to many important intracranial structures, and injury to this region has severe complications if not properly managed. Historically, the goals of frontal sinus fracture management have been to best prevent intracranial complications with invasive procedures, but a recent shift favoring conservative management now aims to preserve the form and function of the frontal sinus and its outflow tract...
May 2017: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/28481385/an-assessment-of-the-safety-of-an-orthopedic-specialty-hospital-a-5-year-experience
#5
Eric M Padegimas, Matthew L Ramsey, Matthew Austin, Javad Parvizi, Gerald R Williams, Kelly Doyle, Michael E West, Richard H Rothman, Alexander R Vaccaro, Surena Namdari
One of the goals of orthopedic specialty hospitals is to provide safe and efficient care to medically optimized patients. The authors' orthopedic specialty hospital is a physician-owned, 24-bed facility that accommodates a multispecialty orthopedic practice in the areas of spine, hip and knee arthroplasty, shoulder and elbow, sports, foot and ankle, and hand surgery. The purpose of this study was to examine the first 5 years of an institutional experience with an orthopedic specialty hospital and to determine if any procedures were at increased risk of postoperative transfer...
May 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/28479461/superior-lower-extremity-vein-graft-bypass-patency-among-married-patients-with-peripheral-arterial-disease
#6
Emily Lagergren, Kelly Kempe, Timothy E Craven, Susan T Kornegay, Justin B Hurie, Nitin Garg, Gabriela Velazquez Ramirez, Matthew S Edwards, Matthew A Corriere
INTRODUCTION: Outcomes disparities associated with lower extremity bypass (LEB) for peripheral arterial disease (PAD) have been identified but are poorly understood. Marital status may affect outcomes through factors related to health risk behaviors, adherence, and access to care but has not been characterized as a predictor of surgical outcomes and is often omitted from administrative datasets. We evaluated associations between marital status and vein graft patency following LEB using multivariable models adjusting for established risk factors...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28473464/alterations-in-3-hydroxyisobutyrate-and-fgf21-metabolism-are-associated-with-protein-ingestion-induced-insulin-resistance
#7
Lydia-Ann L S Harris, Gordon I Smith, Bruce W Patterson, Raja S Ramaswamy, Adewole Okunade, Shannon C Kelly, Lane C Porter, Samuel Klein, Jun Yoshino, Bettina Mittendorfer
Systemic hyperaminoacidemia, induced by either intravenous amino acid infusion or protein ingestion, reduces insulin-stimulated glucose disposal. Studies in mice suggest that the valine metabolite 3-hydroxyisobutyrate (3-HIB), fibroblast growth factor 21 (FGF21), adiponectin, and non-esterified fatty acids (NEFA) may be involved in the amino acid-mediated insulin resistance. We therefore measured the rate of glucose disposal, and plasma 3-HIB, FGF21, adiponectin, and NEFA concentrations in 30 women during basal conditions and during a hyperinsulinemic-euglycemic clamp procedure (HECP) with and without concomitant ingestion of protein (n=15) or an amount of leucine that matched the amount in the protein (n=15)...
May 4, 2017: Diabetes
https://www.readbyqxmd.com/read/28471074/towards-a-contemporary-comprehensive-scoring-system-for-determining-technical-outcomes-of-hybrid-percutaneous-chronic-total-occlusion-treatment-the-recharge-score
#8
Joren Maeremans, James C Spratt, Paul Knaapen, Simon Walsh, Pierfrancesco Agostoni, William Wilson, Alexandre Avran, Benjamin Faurie, Erwan Bressollette, Peter Kayaert, Alan J Bagnall, Dave Smith, Margaret B McEntegart, William H T Smith, Paul Kelly, John Irving, Elliot J Smith, Julian W Strange, Jo Dens
OBJECTIVES: This study sought to create a contemporary scoring tool to predict technical outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) from patients treated by hybrid operators with differing experience levels. BACKGROUND: Current scoring systems need regular updating to cope with the positive evolutions regarding materials, techniques, and outcomes, while at the same time being applicable for a broad range of operators. METHODS: Clinical and angiographic characteristics from 880 CTO-PCIs included in the REgistry of CrossBoss and Hybrid procedures in FrAnce, the NetheRlands, BelGium and UnitEd Kingdom (RECHARGE) were analyzed by using a derivation and validation set (2:1 ratio)...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28463806/salicylate-induced-hyperacusis-in-rats-dose-and-frequency-dependent-effects
#9
Kelly Radziwon, David Holfoth, Julia Lindner, Zoe Kaier-Green, Rachael Bowler, Maxwell Urban, Richard Salvi
The use of auditory reaction time is a reliable measure of loudness perception in both animals and humans with reaction times (RT) decreasing with increasing stimulus intensity. Since abnormal loudness perception is a common feature of hyperacusis, a potentially debilitating auditory disorder in which moderate-intensity sounds are perceived as uncomfortable or painfully loud, we used RT measures to assess rats for salicylate-induced hyperacusis. A previous study using an operant conditioning RT procedure found that high-dose sodium salicylate (SS) induced hyperacusis-like behavior, i...
April 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/28460739/twenty-year-trends-in-the-utilization-of-heller-myotomy-for-achalasia-in-the-united-states
#10
Kelly R Haisley, Jennifer F Preston, James P Dolan, Brian S Diggs, John G Hunter
INTRODUCTION: Trends in the utilization of Heller myotomy for achalasia in the U.S. over time have not been previously described. MATERIALS AND METHODS: Using the Nationwide Inpatient Sample (NIS) database, we analyzed patients undergoing Heller myotomy for achalasia over a 20-year period (1992-2011) to estimate rates of Heller myotomy, locations where the procedures were performed (rural, urban or teaching) and changes in technique (laparoscopic vs open) as well as outcomes of length of stay and in-hospital mortality...
March 15, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28451351/a-new-class-of-cu-zno-catalysts-derived-from-zincian-georgeite-precursors-prepared-by-co-precipitation
#11
Paul J Smith, Simon A Kondrat, Philip A Chater, Benjamin R Yeo, Greg M Shaw, Li Lu, Jonathan K Bartley, Stuart H Taylor, Michael S Spencer, Christopher J Kiely, Gordon J Kelly, Colin W Park, Graham J Hutchings
Zincian georgeite, an amorphous copper-zinc hydroxycarbonate, has been prepared by co-precipitation using acetate salts and ammonium carbonate. Incorporation of zinc into the georgeite phase and mild ageing conditions inhibits crystallisation into zincian malachite or aurichalcite. This zincian georgeite precursor was used to prepare a Cu/ZnO catalyst, which exhibits a superior performance to a zincian malachite derived catalyst for methanol synthesis and the low temperature water-gas shift (LTS) reaction. Furthermore, the enhanced LTS activity and stability in comparison to that of a commercial Cu/ZnO/Al2O3 catalyst, indicates that the addition of alumina as a stabiliser may not be required for the zincian georgeite derived Cu/ZnO catalyst...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28444087/civil-liability-of-the-ophthalmologist-in-the-s%C3%A3-o-paulo-court-of-appeals
#12
Isabel de Fátima Alvim Braga, Kelly de Oliveira Vieira, Thiago Gonçalves Dos Santos Martins
Objective: To conduct a data survey on the subject of medical claims involving civil liability in ophthalmology at the São Paulo Court of Appeals. Methods: A case law research was carried out on the São Paulo Court of Appeals website searching for the keyword "ophthalmologist" for all years until 2016. Results: Of the 65 cases found, 29 were selected. There has been an increase in the number of claims in ophthalmology, especially in surgical procedures on the anterior chamber of the eye...
2017: Einstein
https://www.readbyqxmd.com/read/28438414/predictors-of-trachomatous-trichiasis-surgery-outcome
#13
Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Bizuayehu Gashaw, Guadie S Wondimagegn, Hiwot D Mengistie, Saul N Rajak, Kelly Callahan, Helen A Weiss, Matthew J Burton
PURPOSE: Unfavorable outcomes after trachomatous trichiasis (TT) surgery are undermining the global trachoma elimination effort. This analysis investigates predictors of postoperative TT (PTT), eyelid contour abnormalities (ECAs), and granuloma in the 2 most common TT surgery procedures: posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR). DESIGN: Secondary data analysis from a randomized, controlled, single-masked clinical trial. PARTICIPANTS: A total of 1000 patients with TT, with lashes touching the eye or evidence of epilation, in association with tarsal conjunctival scarring...
April 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28437535/clinical-aspects-of-glucose-transporter-type-1-deficiency-information-from-a-global-registry
#14
Jian Hao, Dorothy I Kelly, Jianzhong Su, Juan M Pascual
Importance: Case reports regularly document unique or unusual aspects of glucose transporter type 1 deficiency (G1D). In contrast, population studies from which to draw global inferences are lacking. Twenty-five years after the earliest case reports, this deficiency still particularly affects treatment and prognostic counseling. Objective: To examine the most common features of G1D. Design, Setting, and Participants: In this study, data were collected electronically from 181 patients with G1D through a web-based, worldwide patient registry from December 1, 2013, through December 1, 2016...
April 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28420300/epinephrine-induced-pulmonary-edema-during-hip-arthroscopy-a-report-of-two-cases-and-a-review-of-the-literature
#15
Nicole S Belkin, Ryan M Degen, Gregory A Liguori, Bryan T Kelly
OBJECTIVES: Hip arthroscopy utilization has significantly increased in recent years. While it is a relatively safe procedure, it is not without risk. Life-threatening complications, albeit rare, can potentially occur and must be appropriately recognized and treated. We describe 2 cases in which patients' undergoing hip arthroscopy developed pulmonary edema and their respective courses of treatment. METHODS: Both patients were being treated for symptomatic femoroacetabular impingement (FAI), with labral tears, requiring operative management after a failed trial of conservative management...
April 26, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28413304/simultaneous-single-staged-repair-of-anorectal-malformation-with-tracheoesophageal-fistula-lessons-learned
#16
Ajay Narayan Gangopadhyay, Vaibhav Pandey
INTRODUCTION: Anorectal malformation (ARM) associated esophageal atresia (EA) with tracheoesophageal fistula (TEF) spawns special therapeutic propositions. The outcome of these patients banks on numerous factors. We performed this study with an aim to compare the outcome of single-staged simultaneous primary repair of both anomalies versus staged repair of these disorders. MATERIALS AND METHODS: Retrospective review of cases with ARM and associated EA with TEF managed over a period of 5 years from July 2010 to June 2015 after ethical approval was undertaken...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28413301/anorectal-malformations-in-males-pros-and-cons-of-neonatal-versus-staged-reconstruction-for-high-and-intermediate-varieties
#17
Prema Menon, Katragadda Lakshmi Narasimha Rao, Amit Kumar Sinha, K Lokesha, Ram Samujh, Jai Kumar Mahajan, Ravi Prakash Kanojia, Monika Bawa
BACKGROUND: High and intermediate types of anorectal malformations (ARMs) in male neonates may be managed either by primary neonatal reconstruction without colostomy cover or by traditional policy of staged reconstruction after neonatal colostomy. Posterior sagittal anorectoplasty (PSARP) is the current widely practiced reconstructive technique with varied results. AIM: To assess our functional results of PSARP without colostomy in male neonates with high and intermediate ARMs compared to 3-stage (neonatal colostomy - PSARP - colostomy closure) methodology in a high volume tertiary care institution of a developing country...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28412539/laparoscopic-reoperative-antireflux-surgery-is-more-cost-effective-than-open-approach
#18
Farzaneh Banki, Matthew Weaver, David Roife, Chandni Kaushik, Anshu Khanna, Kelly Ochoa, Charles C Miller
BACKGROUND: We previously reported on the outcomes of laparoscopic and open reoperative antireflux surgery. The aim of this study was to compare the costs of these procedures. STUDY DESIGN: We performed a retrospective review. Financial and procedure coding data were obtained using a cost accounting system. There were 49 procedures in 46 patients (36 female and 10 male). There were 38 laparoscopic (including 4 conversions) and 11 open procedures (7 transabdominal repairs and 4 gastric-preserving Roux-en-Y esophagojejunostomy)...
April 12, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28407560/genital-and-anal-injuries-a-cross-sectional-australian-study-of-1266-women-alleging-recent-sexual-assault
#19
Renate R Zilkens, Debbie A Smith, Maureen A Phillips, S Aqif Mukhtar, James B Semmens, Maire C Kelly
OBJECTIVES: To describe the frequency of genital and anal injury and associated demographic and assault characteristics in women alleging sexual assault. DESIGN: Cross-sectional study. SETTING: Sexual Assault Resource Centre (SARC), Western Australia. PARTICIPANTS: Total of 1266 women attending SARC from Jan-2009 to Mar-2015. METHODS: Women underwent a standardised data collection procedure by forensically trained doctors...
March 29, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28400697/the-impact-of-individual-surgeon-volume-on-hysterectomy-costs
#20
Jonathan P Shepherd, Charelle M Carter-Brooks, Kelly L Kantartzis, Ted Lee, Michael J Bonidie
BACKGROUND AND OBJECTIVE: Hysterectomy is one of the most common surgical procedures women will undergo in their lifetime. Several factors affect surgical outcomes. It has been suggested that high-volume surgeons favorably affect outcomes and hospital cost. The objective is to determine the impact of individual surgeon volume on total hospital costs for hysterectomy. METHODS: This is a retrospective cohort of women undergoing hysterectomy for benign indications from 2011 to 2013 at 10 hospitals within the University of Pittsburgh Medical Center System...
January 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
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