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JOURNAL ARTICLE
Julie M Fritz, Isaac Ford, Steven Z George, Laura Vinci de Vanegas, Tyler Cope, Colleen A Burke, Adam P Goode
In this perspective, we present our experience developing and conducting two pragmatic clinical trials investigating physical therapist-led telehealth strategies for persons with chronic low back pain. Both trials, the BeatPain Utah and AIM-Back trials, are part of pragmatic clinical trial collaboratories and are being conducted with persons from communities that experience pain management disparities. Practice guidelines recommend nonpharmacologic care, and advise against opioid therapy, for the primary care management of persons with chronic low back pain...
2024: Front Pain Res (Lausanne)
#22
JOURNAL ARTICLE
Tarek Mohamed Ashoor, Abd Elmoniem Hassan Abd Elazim, Zakaria Abd Elaziz Mustafa, Maha Ahmad Anwar, Ihab Ahmad Gad, Ibrahim Mamdouh Esmat
Background: Critically ill patients with sepsis have a high incidence of vitamin D deficiency. Vitamin D promotes the synthesis of human cathelicidin antimicrobial peptide, a precursor of LL-37, which is a part of the innate immune system. This study investigated the effectiveness and safety of the early administration of high-dose enteral vitamin D3 in comparison with low-dose vitamin D3 in patients with sepsis requiring mechanical ventilation (MV). Methods: Eighty adult patients with sepsis requiring MV with known vitamin D deficiency were randomly assigned to receive either an enteral 50 000 IU (Group I) or 5000 IU (Group II) vitamin D supplementation...
May 5, 2024: Journal of Intensive Care Medicine
#23
RANDOMIZED CONTROLLED TRIAL
Brittany Dennis, Adam Deane, François Lauzier, Nicole Zytaruk, Miranda Hardie, Naomi Hammond, Simon Finfer, Yaseen Arabi, John Marshall, Lois Saunders, Diane Heels-Ansdell, John Myburgh, Serena Knowles, John Muscedere, Marlies Ostermann, Dorrilyn Rajbhandari, Shane English, Karlo Matic, Bala Venkatesh, Abdulrahman Al Fares, Gordon Guyatt, Waleed Alhazzani, Hassan Mumtaz, Alexis Poole, Feng Xie, Lehana Thabane, Richard Hall, Deborah Cook
BACKGROUND: During the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus on COVID-19-specific studies. OBJECTIVE: To describe the conduct of an international randomized trial of stress ulcer prophylaxis (Re-Evaluating the Inhibition of Stress Erosions in the ICU [REVISE]) during the pandemic, addressing enrolment patterns, center engagement, informed consent processes, data collection, a COVID-specific substudy, patient transfers, and data monitoring...
May 4, 2024: BMC Medical Research Methodology
#24
JOURNAL ARTICLE
K D Crew, G L Anderson, K B Arnold, A P Stieb, J N Amenta, N Collins, C W Law, S Pruthi, A Sandoval-Leon, D Bertoni, M T Grosse Perdekamp, S Colonna, S Krisher, T King, L D Yee, T J Ballinger, C Braun-Inglis, D Mangino, K B Wisinski, C A DeYoung, M Ross, J Floyd, A Kaster, L Vander Walde, T Saphner, C Zarwan, S Lo, C Graham, A Conlin, K Yost, D Agnese, C Jernigan, D L Hershman, M L Neuhouser, B Arun, R Kukafka
INTRODUCTION: Women with atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS) have a significantly increased risk of breast cancer, which can be substantially reduced with antiestrogen therapy for chemoprevention. However, antiestrogen therapy for breast cancer risk reduction remains underutilized. Improving knowledge about breast cancer risk and chemoprevention among high-risk patients and their healthcare providers may enhance informed decision-making about this critical breast cancer risk reduction strategy...
May 2, 2024: Contemporary Clinical Trials
#25
JOURNAL ARTICLE
Alessandro De Cassai, Tommaso Pettenuzzo, Veronica Busetto, Christian Legnaro, Chiara Pretto, Alessio Rotondi, Annalisa Boscolo, Nicolò Sella, Marina Munari, Paolo Navalesi
INTRODUCTION: Oral chlorhexidine has been widely used for ventilator-associated pneumonia prevention in the critical care setting; however, previous studies and evidence synthesis have generated inconsistent findings. Our study aims to investigate if different concentrations of oral chlorhexidine may be effective in preventing such complication in intensive care unit patients. METHODS: After pre-registration (Open Science Framework: 8CUKF), we conducted a network meta-analysis with the following PICOS: adult patients (age > 18 years old) undergoing invasive mechanical ventilation admitted in ICU (P); any concentration of chlorhexidine used for oral hygiene (I); placebo, sham intervention, usual care, or no intervention (C); rate of VAP (primary outcome), mechanical ventilation length, ICU length of stay (LOS), hospital LOS, mortality (secondary outcomes) (O); randomized controlled trials (S)...
May 3, 2024: J Anesth Analg Crit Care
#26
JOURNAL ARTICLE
Bin Lu, Yang Xu, Na Li, Yueyang Zhou, Xudong Ma, Yan Chen, Run Dong, Xiang Zhou, Min Dai, Hongda Chen, Li Weng, Bin Du
No abstract text is available yet for this article.
March 25, 2024: Science Bulletin
#27
JOURNAL ARTICLE
Matthew F Mart, Leanne M Boehm, Amy L Kiehl, Michelle N Gong, Atul Malhotra, Robert L Owens, Babar A Khan, Margaret A Pisani, Gregory A Schmidt, R Duncan Hite, Matthew C Exline, Shannon S Carson, Catherine L Hough, Peter Rock, Ivor S Douglas, Daniel J Feinstein, Robert C Hyzy, William D Schweickert, David L Bowton, Andrew Masica, Onur M Orun, Rameela Raman, Brenda T Pun, Cayce Strength, Mark L Rolfsen, Pratik P Pandharipande, Nathan E Brummel, Christopher G Hughes, Mayur B Patel, Joanna L Stollings, E Wesley Ely, James C Jackson, Timothy D Girard
BACKGROUND: Delirium is common during critical illness and is associated with long-term cognitive impairment and disability. Antipsychotics are frequently used to treat delirium, but their effects on long-term outcomes are unknown. We aimed to investigate the effects of antipsychotic treatment of delirious, critically ill patients on long-term cognitive, functional, psychological, and quality-of-life outcomes. METHODS: This prespecified, long-term follow-up to the randomised, double-blind, placebo-controlled phase 3 MIND-USA Study was conducted in 16 hospitals throughout the USA...
April 30, 2024: Lancet Respiratory Medicine
#28
JOURNAL ARTICLE
Marie-Louise Zeissler, Nikul Bakshi, Michèle Bartlett, Amit Batla, David Byrom, Rebecca Chapman, Sally Collins, Elaine Cowd, Eric Deeson, Romy Ellis-Doyle, Jodie Forbes, Cristina Gonzalez-Robles, Anna Jewell, Emma L Lane, Nancy R LaPelle, Keith Martin, Helen Matthews, Laurel Miller, Georgia Mills, Antony Morgan, Miriam Parry, Kuhan Pushparatnam, Natasha Ratcliffe, Dorothy Salathiel, Paula Scurfield, Carroll Siu, Sue Whipps, Sheila Wonnacott, Thomas Foltynie, Camille B Carroll, Kevin McFarthing
BACKGROUND: Patient and public involvement and engagement (PPIE) in the design of trials is important, as participant experience critically impacts delivery. The Edmond J Safra Accelerating Clinical Trials in PD (EJS ACT-PD) initiative is a UK consortium designing a platform trial for disease modifying therapies in PD. OBJECTIVE: The integration of PPIE in all aspects of trial design and its evaluation throughout the project. METHODS: PwP and care partners were recruited to a PPIE working group (WG) via UK Parkinson's charities, investigator patient groups and participants of a Delphi study on trial design...
April 27, 2024: Journal of Parkinson's Disease
#29
JOURNAL ARTICLE
Sukeshana Srivastav, Rubens Spin-Neto, Akila Aiyar, Peter Bangsgaard Stoustrup
BACKGROUND: Magnetic resonance imaging (MRI) is a non-ionizing imaging technique. Using MRI in dentistry may potentially lower the general radiation dose of the examined population, provided MRI can replace various radiation-based images. Furthermore, novel MRI imaging modalities for three-dimensional and two-dimensional cephalometrics have recently been developed for orthodontic diagnosis. OBJECTIVES: This systematic review aimed to determine the diagnostic accuracy and reliability of MRI in orthodontic diagnosis and treatment planning...
June 1, 2024: European Journal of Orthodontics
#30
JOURNAL ARTICLE
Yaseen M Arabi, Hasan M Al-Dorzi, Omar Aldibaasi, Musharaf Sadat, Jesna Jose, Dina Muharib, Haifa Algethamy, Abdulrahman A Al-Fares, Fahad Al-Hameed, Ahmed Mady, Ayman Kharaba, Ali Al Bshabshe, Khalid Maghrabi, Khalid AlGhamdi, Ghulam Rasool, Adnan AlGhamdi, Ghaleb A Almekhlafi, Jamal Chalabi, Haifaa Ibrahim AlHumedi, Maram Hasan Sakkijha, Norah Khalid Alamrey, Amjad Sami Alaskar, Rabeah Hamad Alhutail, Kaouthar Sifaoui, Rakan Alqahtani, Ahmad S Qureshi, Mohammed Moneer Hejazi, Hatim Arishi, Samah AlQahtani, Amro Mohamed Ghazi, Saleh T Baaziz, Abeer Othman Azhar, Sara Fahad Alabbas, Mohammed AlAqeely, Ohoud AlOrabi, Aliaa Al-Mutawa, Maha AlOtaibi, Madiha Fawazy Elghannam, Mohammed Almaani, Sarah Fadel Buabbas, Wadiah Alawi M Alfilfil, Mohammed S Alshahrani, Joel Starkopf, Jean-Charles Preiser, Anders Perner, Jumana Hani AlMubarak, Wafa Mansoor Hazem, Talal Albrahim, Abdulaziz Al-Dawood
BACKGROUND: The optimal amount and timing of protein intake in critically ill patients are unknown. REPLENISH (Replacing Protein via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients) trial evaluates whether supplemental enteral protein added to standard enteral nutrition to achieve a high amount of enteral protein given from ICU day five until ICU discharge or ICU day 90 as compared to no supplemental enteral protein to achieve a moderate amount of enteral protein would reduce all-cause 90-day mortality in adult critically ill mechanically ventilated patients...
May 2, 2024: Trials
#31
REVIEW
Cornelius H L Kürten, Robert L Ferris
The neoadjuvant immunotherapy approach marks a significant shift in the treatment paradigm of potentially curable HNSCC. Here, current therapies, despite being highly individualized and advanced, often fall short in achieving satisfactory long-term survival rates and are frequently associated with substantial morbidity.The primary advantage of this approach lies in its potential to intensify and enhance treatment regimens, offering a distinct modality that complements the existing triad of surgery, radiotherapy, and chemotherapy...
May 2024: Laryngo- Rhino- Otologie
#32
JOURNAL ARTICLE
Takahiro Hakozaki, Takayuki Hasegawa, Satoki Inoue
BACKGROUND: Advancing a tracheal tube over a tracheal tube exchanger into the trachea frequently causes difficulties because of the tube impingement on laryngeal structures. In the present study, we measured the resistance of tube advancement both objectively and subjectively with a variety of combinations of tube exchanger sizes and tracheal tubes using a manikin simulator. METHODS: Lubricated 7.5 mm ID standard and Parker Flex-Tip (PFT) tracheal tubes were railroaded over the tube exchangers (OD 1-6 mm) into the trachea through the oral route in a manikin...
December 1, 2023: Asian Journal of Anesthesiology
#33
REVIEW
Iva Kosuta, Madhumita Premkumar, K Rajender Reddy
BACKGROUND: The increase in prevalence of liver disease globally will lead to a substantial incremental burden on intensive care requirements. While liver transplantation offers a potential life-saving intervention, not all patients are eligible due to limitations such as organ availability, resource constraints, ongoing sepsis or multiple organ failures. Consequently, the focus of critical care of patients with advanced and decompensated cirrhosis turns to liver-centric intensive care protocols, to mitigate the high mortality in such patients...
May 1, 2024: Alimentary Pharmacology & Therapeutics
#34
JOURNAL ARTICLE
Alexandra-Maria Stommel, Harald Herkner, Calvin Lukas Kienbacher, Brigitte Wildner, Alexander Hermann, Thomas Staudinger
PURPOSE: A systematic review and meta-analysis to evaluate the impact of extracorporeal carbon dioxide removal (ECCO2 R) on gas exchange and respiratory settings in critically ill adults with respiratory failure. METHODS: We conducted a comprehensive database search, including observational studies and randomized controlled trials (RCTs) from January 2000 to March 2022, targeting adult ICU patients undergoing ECCO2 R. Primary outcomes were changes in gas exchange and ventilator settings 24 h after ECCO2 R initiation, estimated as mean of differences, or proportions for adverse events (AEs); with subgroup analyses for disease indication and technology...
April 30, 2024: Critical Care: the Official Journal of the Critical Care Forum
#35
RANDOMIZED CONTROLLED TRIAL
Serap Gungor, Betul Tosun, Gozde Candir, Nurten Ozen
This study aims to investigate the effects of intraoral cold water spray on thirst, frequency of oral care and postoperative period pain at surgical incision site in patients having abdominal surgery. The study was carried out as a randomized controlled trial, registered under Clinical Trial Number: NCT05940818. The study involved 110 participants, divided equally into two groups (n = 55): the experimental group and the control group. Data were collected using patient information form, NRS, Intensive Care Oral Care Frequency Assessment Scale (ICOCFAS) and Visual Analog Scale (VAS)...
May 1, 2024: Scientific Reports
#36
RANDOMIZED CONTROLLED TRIAL
Mangyeong Lee, Danbee Kang, Yesol Um, Bokyung Jo, Jeong Rhue, Sehhoon Park, Yoo-Young Lee, Joseph J Noh, Yun-Gyoo Lee, Dong-Hoe Koo, Kyong-Hwa Park, Soohyeon Lee, Jin Seok Ahn, Dongryul Oh, Juhee Cho
INTRODUCTION: Symptoms due to chemotherapy are common in patients with cancer. Cancer-related symptoms are closely associated with the deterioration of physical function which can be associated with decreased quality of life and increased mortality. Thus, timely symptom identification is critical for improving cancer prognosis and survival. Recently, remote symptom monitoring system using digital technology has demonstrated its effects on symptom control or survival. However, few studies examined whether remote monitoring would contribute to retaining physical function among patients with cancer...
May 1, 2024: BMJ Open
#37
JOURNAL ARTICLE
Vassilis G Giannakoulis, Edward J Schenck, Eleni Papoutsi, David R Price, Jesús Villar, Hina Sarwath, Frank Schmidt, B Taylor Thompson, Augustine M K Choi, Ilias I Siempos
No abstract text is available yet for this article.
May 1, 2024: American Journal of Respiratory and Critical Care Medicine
#38
EDITORIAL
Marilyn K Glassberg, Alissa Ali, Gina Gregorini
No abstract text is available yet for this article.
May 1, 2024: American Journal of Respiratory and Critical Care Medicine
#39
EDITORIAL
Elizabeth R Volkmann, Donald P Tashkin
No abstract text is available yet for this article.
May 1, 2024: American Journal of Respiratory and Critical Care Medicine
#40
REVIEW
Georgia A Wilke, Rajendra S Apte
Careful regulation of the complement system is critical for enabling complement proteins to titrate immune defense while also preventing collateral tissue damage from poorly controlled inflammation. In the eye, this balance between complement activity and inhibition is crucial, as a low level of basal complement activity is necessary to support ocular immune privilege, a prerequisite for maintaining vision. Dysregulated complement activation contributes to parainflammation, a low level of inflammation triggered by cellular damage that functions to reestablish homeostasis, or outright inflammation that disrupts the visual axis...
May 1, 2024: Journal of Clinical Investigation
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