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https://www.readbyqxmd.com/read/28944859/protective-and-therapeutic-effects-of-danhong-injection-on-acute-pancreatitis%C3%A2-associated-lung-injury
#1
Qin Liu, Fuzhou Hua, Changqing Deng, Jing Zhang, Guohai Xu, Yanhui Hu
Lung functional impairment caused by acute pancreatitis (AP) is the primary contributor to AP‑associated mortality. Previous studies have reported that AP‑associated lung injury is associated with systemic inflammatory response syndrome and oxidative stress. In the present study, the protective effects of Danhong injection (DHI), a widely used Chinese Traditional Medicine preparation, on AP‑associated lung injury in rats was examined. The myeloperoxidase activity, malondiadelhyde level and superoxide dismutase activity determination demonstrated the anti‑inflammatory and anti‑oxidative properties of DHI...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944743/alginate-combined-cholic-acid-increased-insulin-secretion-of-microencapsulated-mouse-cloned-pancreatic-%C3%AE-cells
#2
Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan, Hani Al-Salami
AIM: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due to its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed to examine antidiabetic effects of a PBA, in terms of cellular inflammation and survival and insulin release, in the context of supporting β-cell delivery and Type 1 diabetic treatment. MATERIALS & METHODS: 10 formulations were prepared, five without PBA (control) and five with PBA (test)...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944626/caveolin-1-secreted-from-adipose-tissues-and-adipocytes-functions-as-an-adipogenesis-enhancer
#3
Chia-Chu Chang, Chen-Yu Chen, Hui-Chin Wen, Chih-Yang Huang, Ming-Shiu Hung, Hsi-Chi Lu, Woan-Ling Chen, Chung-Ho Chang
OBJECTIVE: Caveolin-1 (Cav-1) is expressed abundantly in adipose tissue and involved in many physiological processes. While Cav-1 has been reported to be secreted in pancreatic acinar cells and LNCaP prostate cancer cells, its secretion from adipose tissue awaits investigation. METHODS: Cav-1 secretion from 3T3-L1 adipocytes and fat tissues from normal chow diet- and high-fat diet (HFD)-fed mice was measured. Functions and uptake of secreted Cav-1 proteins were assessed by adding Cav-1 back to preadipocytes and LNCaP cells...
September 25, 2017: Obesity
https://www.readbyqxmd.com/read/28944336/development-of-acute-cholecystitis-following-laparoscopic-partial-cholecystectomy
#4
Oktay Karaköse, Mehmet Zafer Sabuncuoğlu, Mehmet Fatih Benzin, Girayhan Çelik, Mahmut Bülbül, Hüseyin Pülat
In cases where the dissection of Calot's triangle is difficult during laparoscopic cholecystectomy, laparoscopic partial cholecystectomy is an alternative to total cholecystectomy to prevent bile duct damage. However, recurrent symptoms and bile duct problems associated with the remaining gallbladder tissue may develop in patients over time. The case of a 45-year-old male who underwent laparoscopic partial cholecystectomy one year previously is presented here. In the postoperative period, as a result of tests for the continuing symptoms of cholecystitis, stones and surrounding abscess were detected in the remaining gallbladder tissue, so open completion cholecystectomy was applied...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944326/the-anti-inflammatory-effect-of-hydrogen-sulphide-on-acute-necrotizing-pancreatitis-in-rats
#5
Kutay Sağlam, Etem Alhan, Serdar Türkyılmaz, Birgül Kural Vanizor, Cengiz Erçin
OBJECTIVE: The aim of this study was to investigate the dose-dependent anti-inflammatory effect of the Hydrogen sulfidedonor sodiumhydrosulphide on acute necrotizing pancreatitis in rats. MATERIAL AND METHODS: A total of 42 male Sprague-Dawley rats were divided into 4 groups: sham+saline (group 1), sham+NaHS (group 2), acute necrotizing pancreatitis+saline (group 3), and acute necrotizing pancreatitis+NaHS (group 4). Acute pancreatitis was induced in rats in groups 3 and 4 with the infusion of glycodeoxycholic acidinto the biliopancreatic canal and infusion of cerulein parenterally...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944325/comparison-of-contrast-enhanced-ct-with-diffusion-weighted-mri-in-the-evaluation-of-patients-with-acute-biliary-pancreatitis
#6
Mehmet İlhan, Muhammet Üçüncü, Ali Fuat Kaan Gök, Gizem Öner, Elidor Agolli, Bahar Canbay, Barış Bakır, Recep Güloğlu, Cemalettin Ertekin
OBJECTIVE: The aim of this study was to compare contrast-enhanced computed tomography with diffusion-weighted magnetic resonance imaging in the evaluation of patients with acute biliary pancreatitis. MATERIAL AND METHODS: Fifty-three patients diagnosed with acute biliary pancreatitis, between February 2012 and July 2015, were evaluated using diffusion-weighted magnetic resonance imaging and magnetic resonance cholangiopancreatography to explain the elevation of cholestasis enzymes and bilirubin levels at "stanbul University...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944138/surgical-treatments-for-patients-with-recurrent-bile-duct-stones-and-oddis-sphincter-laxity
#7
REVIEW
Boxuan Zhou, Jinxiong Hu, Yuesi Zhong
Recurrent bile duct stones is the most common complication after gallstone surgery and the incidence is about 4-24%. Sphincter of Oddi laxity will lead to duodenal content flow into the bile or pancreatic duct. Patients with recurrent bile duct stones and Oddis sphincter laxity were intractable. Here we sought to present the possible and helpful surgical treatments for such patients. Prospective randomized clinical trial are needed for evaluating the outcome of surgical treatments.
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28944047/novel-biomarkers-and-endoscopic-techniques-for-diagnosing-pancreaticobiliary-malignancy
#8
REVIEW
Margaret G Keane, Amar Shah, Stephen P Pereira, Deepak Joshi
The UK incidence of pancreatic ductal adenocarcinoma is 9 per 100,000 population, and biliary tract cancer occurs at a rate of 1-2 per 100,000. The incidence of both cancers is increasing annually and these tumours continue to be diagnosed late and at an advanced stage, limiting options for curative treatment. Population-based screening programmes do not exist for these cancers, and diagnosis currently is dependent on symptom recognition, but often symptoms are not present until the disease is advanced. Recently, a number of promising blood and urine biomarkers have been described for pancreaticobiliary malignancy and are summarised in this review...
2017: F1000Research
https://www.readbyqxmd.com/read/28943967/kr%C3%A3-ppel-like-factor-8-induces-epithelial-to-mesenchymal-transition-and-promotes-invasion-of-pancreatic-cancer-cells-through-transcriptional-activation-of-four-and-a-half-lim-only-protein-2
#9
Xiaoping Yi, Hongyan Zai, Xueying Long, Xiaoyi Wang, Wenzheng Li, Yixiong Li
Pancreatic cancer (PC) is one of the most aggressive types of cancer with an extremely poor prognosis. Invasive growth and early metastasis is one of the greatest challenges to overcome for the treatment of PC. Numerous previous studies have indicated that the transcription factor Krüppel-like factor 8 (KLF8) and nuclear cofactor four and a half LIM-only protein 2 (FHL2) serve important roles in tumorigenesis and tumor progression; however, their roles in PC remain elusive. The present study revealed that KLF8 and FHL2 expression is aberrantly co-overexpressed in PC tissue samples and associated with tumor metastasis...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943931/a-missing-link-between-ron-expression-and-oncological-outcomes-in-resected-left-sided-pancreatic-cancer
#10
Dai Hoon Han, Chang Moo Kang, Sung Whan Lee, Ho Kyoung Hwang, Woo Jung Lee
Alteration and activation of recepteur d'origine nantais (RON) expression is known to be associated with cancer progression and decreased survival in various types of human cancer, including pancreatic cancer. Therefore, in the present study, RON expression levels were determined in resected left-sided pancreatic cancer to evaluate the potential oncological role of RON in the clinical setting of distal pancreatic cancer. From January 2005 to December 2011, a total of 57 patients underwent radical distal pancreatectomy for left-sided pancreatic cancer...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943810/type-1-diabetes-a-clinical-perspective
#11
Lindy Kahanovitz, Patrick M Sluss, Steven J Russell
Type 1 diabetes is a disease in which autoimmune destruction of pancreatic β-cells leads to insulin deficiency. Controlling blood glucose with an acceptable range is a major goal of therapy. Measurements of hemoglobin A1c and blood glucose levels are used for both the diagnosis and the long-term management of the disease. This chapter briefly describes the pathophysiology, diagnosis, and management of type 1 diabetes.
March 2017: Point of Care
https://www.readbyqxmd.com/read/28943578/suppression-of-extrapancreatic-glucagon-by-octreotide-may-reduce-the-fasting-and-postprandial-glucose-levels-in-a-diabetic-patient-after-total-pancreatectomy-a-case-report
#12
Hideyuki Okuma, Ryotaro Bouchi, Seizaburo Masuda, Takato Takeuchi, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
A 52-year-old woman was treated with sensor augmented pump therapy after undergoing total pancreatectomy for a nonfunctional pancreatic neuroendocrine tumor (NET). The secretion of both endogenous insulin and pancreatic glucagon were completely depleted. Octreotide long acting repeatable (Oct-LAR) was administered for the treatment of liver metastasis of NET. Both the fasting and postprandial glucagon levels decreased immediately after the administration of Oct-LAR. In a continuous glucose monitoring analysis, episodes of nocturnal hypoglycemia was found to increase and an improvement of postprandial hyperglycemia was observed...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943576/sarcoidosis-with-pancreatic-mass-endobronchial-nodules-and-miliary-opacities-in-the-lung
#13
Shun Matsuura, Yasutaka Mochizuka, Kyohei Oishi, Koichi Miyashita, Hyogo Naoi, Eisuke Mochizuki, Shinichiro Mikura, Masaru Tsukui, Naoki Koshimizu, Akihiko Ohata, Takahumi Suda
Sarcoidosis affects multiple organs and rarely has unusual manifestations. A 78-year-old woman was referred to our hospital for coughing symptoms. A chest computed tomography (CT) scan revealed bilateral diffuse miliary patterns and right pleural effusion. Bronchoscopy showed multiple nodules in the carina and the bronchus intermedius. A CT scan of her abdomen revealed hypovascular lesions involving the pancreatic head and body. A transbronchial lung biopsy, bronchial mucosal biopsy, and endoscopic ultrasound-guided fine-needle aspiration of the pancreatic mass demonstrated non-caseating granulomas...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943513/neonatal-diabetes-two-cases-with-isolated-pancreas-agenensis-due-to-homozygous-ptf1a-enhancer-mutations-and-one-with-dend-syndrome-due-to-kcnj11-mutation
#14
Olcay Evliyaoğlu, Oya Ercan, Emel Ataloğlu, Ümit Zübarioğlu, Bahar Özcabı, Aydilek Dağdeviren, Hande Erdoğan, Elisa De Franco, Sian Ellard
Neonatal diabetes mellitus is a rare form of monogenic diabetes which is diagnosed in the first 6 months of life. Here we report three patients with neonatal diabetes; two with isolated pancreas agenesis due to mutations in the PTF1A enhancer and one with DEND syndrome (developmental delay, epilepsy, and neonatal diabetes) due to a KCNJ11 mutation. The two cases with mutations in the distal enhacer of PTF1A had a homozygous g.23508363A>G and a homozygous g.23508437A>G mutation respectively. Previous functional analysis showed that these mutations can decrease expression of PTF1A which is involved in pancreas development...
September 25, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28943487/risk-prediction-for-portal-vein-thrombosis-in-acute-pancreatitis-using-radial-basis-function
#15
Yang Fei, Jian Hu, Kun Gao, Jianfeng Tu, Wei Wang, Wei-Qin Li
OBJECTIVE: The aim of this study is to predict the risk of acute pancreatitis (AP)-induced portal vein thrombosis(PVT) by radical basis function (RBF) artificial neural networks (ANNs) model. METHODS: A retrospective or consecutive study of 426 individuals with AP at our unit between January 1(st) 2011 to July 31(st) 2016 was conducted. All individuals were subjected to RBF ANNs. Variables included age, gender, red blood cell specific volume (Hct), prothrombin time (PT), fasting blood glucose (FBG), D-Dimer, concentration of serum calcium ([Ca(2+)]), triglyceride (TG), serum amylase (AMY), acute physiology and chronic health evaluation II (APACHEII) score, and Ranson score...
September 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28943397/can-standardized-pathology-examination-increase-the-lymph-node-yield-following-laparoscopic-distal-pancreatectomy-for-ductal-adenocarcinoma
#16
Mushegh A Sahakyan, Sven P Haugvik, Bård I Røsok, Airazat M Kazaryan, Dejan Ignjatovic, Trond Buanes, Knut J Labori, Caroline S Verbeke, Bjørn Edwin
BACKGROUND: Lymph node yield (LNY) is an indicator of oncological adequacy of surgery in patients with pancreatic ductal adenocarcinoma (PDAC). Our hypothesis is that standardized pathology examination (SPE) aimed at accurate staging can increase the LNY without changing surgical technique. METHODS: After the introduction of SPE for distal pancreatosplenectomy specimens at Oslo University Hospital, prospective data were collected on patients with PDAC undergoing laparoscopic distal pancreatosplenectomy (LDP)...
September 21, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28943396/pancreatectomy-combined-with-multivisceral-resection-for-pancreatic-malignancies-is-it-justified-results-of-a-systematic-review
#17
REVIEW
Niccolò Petrucciani, Tarek Debs, Giuseppe Nigri, Giulia Giannini, Elena Sborlini, Radwan Kassir, Imed Ben Amor, Antonio Iannelli, Stefano Valabrega, Francesco D'Angelo, Jean Gugenheim, Giovanni Ramacciato
BACKGROUND: Multivisceral resections combined with pancreatectomy have been proposed in selected patients with tumor invasion into adjacent organs, in order to allow complete tumor resection. Some authors have also reported multivisceral resection combined with metastasectomy in very selected cases. The utility of this practice is debated. The aim of the review is to compare the postoperative results and survival of pancreatectomies combined with multivisceral resections with those of standard pancreatectomies...
September 21, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28943195/diels-alder-mediated-release-of-gemcitabine-from-hybrid-nanoparticles-for-enhanced-pancreatic-cancer-therapy
#18
Adeolu Oluwasanmi, Wejdan Al-Shakarchi, Ayesha Manzur, Mohammed H Aldebasi, Rayan S Elsini, Malek K Albusair, Katherine J Haxton, Anthony D M Curtis, Clare Hoskins
Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was developed by introducing a linker between HNPs and gemcitabine. Whereby, heat generation resulting from laser irradiation of the HNPs promoted linker breakdown resulting in prodrug liberation. In vitro evaluation in pancreatic adenocarcinoma cells, showed the prodrug was 4...
September 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28943075/a-novel-absorbable-radiopaque-hydrogel-spacer-to-separate-the-head-of-the-pancreas-and-duodenum-in-radiation-therapy-for-pancreatic-cancer
#19
Avani D Rao, Ziwei Feng, Eun Ji Shin, Jin He, Kevin M Waters, Stephanie Coquia, Robert DeJong, Lauren M Rosati, Lin Su, Dengwang Li, Juan Jackson, Stephen Clark, Jeffrey Schultz, Danielle Hutchings, Seong-Hun Kim, Ralph H Hruban, Theodore L DeWeese, John Wong, Amol Narang, Joseph M Herman, Kai Ding
PURPOSE: We assessed the feasibility and theoretical dosimetric advantages of an injectable hydrogel to increase the space between the head of the pancreas (HOP) and duodenum in a human cadaveric model. METHODS AND MATERIALS: Using 3 human cadaveric specimens, an absorbable radiopaque hydrogel was injected between the HOP and duodenum by way of open laparotomy in 1 case and endoscopic ultrasound (EUS) guidance in 2 cases. The cadavers were subsequently imaged using computed tomography and dissected for histologic confirmation of hydrogel placement...
August 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28942790/glucagon-like-peptide-1-receptor-agonists-a-class-update-for-treating-type-2-diabetes
#20
REVIEW
Julie A Lovshin
Current management options for treating type 2 diabetes are diverse. Many different classes of antidiabetes therapies are used in clinic, and several new candidates are in late-phase clinical trial. This therapeutic abundance is a windfall for patients because it facilitates individualized patient care. Evidence-based positioning of these agents is challenging, however, requiring comprehensive and balanced familiarity with each drug class. In this review, I provide a clinical update of glucagon-like peptide-1 receptor agonists (GLP-1RAs), a class of incretin-based, injectable antidiabetes therapies which improve fasting and postprandial blood glucose control through glucose-dependent pancreatic islet cell hormone secretion without significant risks for hypoglycemia...
October 2017: Canadian Journal of Diabetes
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