keyword
https://read.qxmd.com/read/38452715/how-well-does-peripheral-blood-neutrophil-to-lymphocyte-ratio-predict-the-severity-and-prognosis-of-hemorrhagic-stroke
#21
JOURNAL ARTICLE
Anadi Mishra, Ruchika Tandon, Vimal Paliwal, Sanjeev Jha
OBJECTIVE: We explored the blood neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker and its relation with mortality and Modified Rankin Scale (mRS) score at discharge and at 3 months following ICH and also compared NLR with intracerebral hemorrhage (ICH) score, Sequential Organ Failure Assessment (SOFA) score and National Institutes of Health Stroke Scale (NIHSS) score. METHODS: The investigators calculated the NIHSS score, SOFA score, ICH score and NLR of 90 adult patients within 3 days of onset of stroke with evidence of hemorrhagic stroke in brain imaging and correlated it with in-hospital mortality, 3-month mortality and mRS at 3 months following stroke using regression analysis...
February 28, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38444306/a-neutrophil-hijacking-nanoplatform-reprograming-netosis-for-targeted-microglia-polarizing-mediated-ischemic-stroke-treatment
#22
JOURNAL ARTICLE
Na Yin, Wenya Wang, Fei Pei, Yuzhen Zhao, Changhua Liu, Mingming Guo, Kaixiang Zhang, Zhenzhong Zhang, Jinjin Shi, Yun Zhang, Zhi-Hao Wang, Junjie Liu
Precise and efficient regulation of microglia is vital for ischemic stroke therapy and prognosis. The infiltration of neutrophils into the brain provides opportunities for regulatory drugs across the blood-brain barrier, while hindered by neutrophil extracellular traps (NETs) and targeted delivery of intracerebral drugs to microglia. This study reports an efficient neutrophil hijacking nanoplatform (referred to as APTS) for targeted A151 (a telomerase repeat sequence) delivery to microglia without the generation of NETs...
March 5, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38437534/endothelial-peroxiredoxin-4-is-indispensable-for-blood-brain-barrier-integrity-and-long-term-functional-recovery-after-ischemic-stroke
#23
JOURNAL ARTICLE
Na Xu, Xiaoyan Jiang, Wenting Zhang, Yejie Shi, Rehana K Leak, Richard F Keep, Qing Ye, Tuo Yang, Sicheng Li, Xiaoming Hu, R Anne Stetler, Michael V L Bennett, Jun Chen
The endothelial lining of cerebral microvessels is damaged relatively early after cerebral ischemia/reperfusion (I/R) injury and mediates blood-brain barrier (BBB) disruption, neurovascular injury, and long-term neurological deficits. I/R induces BBB leakage within 1 h due to subtle structural alterations in endothelial cells (ECs), including reorganization of the actin cytoskeleton and subcellular redistribution of junctional proteins. Herein, we show that the protein peroxiredoxin-4 (Prx4) is an endogenous protectant against endothelial dysfunction and BBB damage in a murine I/R model...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38420850/no-reflow-after-recanalization-in-ischemic-stroke-from-pathomechanisms-to-therapeutic-strategies
#24
REVIEW
Feiyue Sun, Jing Zhou, Xiangyu Chen, Tong Yang, Guozuo Wang, Jinwen Ge, Zhanwei Zhang, Zhigang Mei
Endovascular reperfusion therapy is the primary strategy for acute ischemic stroke. No-reflow is a common phenomenon, which is defined as the failure of microcirculatory reperfusion despite clot removal by thrombolysis or mechanical embolization. It has been reported that up to 25% of ischemic strokes suffer from no-reflow, which strongly contributes to an increased risk of poor clinical outcomes. No-reflow is associated with functional and structural alterations of cerebrovascular microcirculation, and the injury to the microcirculation seriously hinders the neural functional recovery following macrovascular reperfusion...
February 29, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38420847/potential-protein-signatures-for-recurrence-prediction-of-ischemic-stroke
#25
JOURNAL ARTICLE
Chengyi Zhang, Yang Liu, Huimin Zhu, Xinying Huang, Cang Guo, Si Cheng, Meng Yuan, Yong Jiang, Xia Meng, S Claiborne Johnston, Yongjun Wang, Wei-Na Jin, Fu-Dong Shi
BACKGROUND: Acute ischemic stroke is a major cause of mortality and disability worldwide, with approximately 7.4% to 7.7% recurrence within the first 3 months. This study aimed to identify potential biomarkers for predicting stroke recurrence. METHODS AND RESULTS: We conducted a nested case-control study using a hospital-based cohort from the Third China National Stroke Registry selecting 214 age- and sex-matched patients with ischemic stroke with hypertension and no history of diabetes or heart disease...
February 29, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38417245/systemic-immune-inflammation-index-as-a-predictor-of-early-stroke-progression-recurrence-in-acute-atherosclerotic-ischemic-stroke
#26
JOURNAL ARTICLE
Mina Lee, Eun Ji Lee, Rae On Kim, Jung-Min Pyun, Byung-Euk Joo, Kyum-Yil Kwon, Hakjae Roh, Moo-Young Ahn, Kyungbok Lee
OBJECTIVES: Although the systemic immune-inflammatory index (SII) has recently been correlated with stroke severity and functional outcome, the underlying pathogenesis remains largely unknown. The objective of this study was to explore whether SII could predict early neurologic deterioration (END) in different etiologies of acute ischemic stroke. MATERIALS AND METHODS: From January 2019 to December 2021, a total of 697 consecutive patients with acute ischemic stroke, admitted within 72 hours from stroke onset, were prospectively enrolled...
February 18, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38405916/unbiased-characterization-of-atrial-fibrillation-phenotypic-architecture-provides-insight-to-genetic-liability-and-clinically-relevant-outcomes
#27
Giovanni Davogustto, Shilin Zhao, Yajing Li, Eric Farber-Eger, Brandon D Lowery, Lauren Lee Shaffer, Jonathan D Mosley, M Benjamin Shoemaker, Yaomin Xu, Dan M Roden, Quinn S Wells
BACKGROUND: Atrial Fibrillation (AF) is a common and clinically heterogeneous arrythmia. Machine learning (ML) algorithms can define data-driven disease subtypes in an unbiased fashion, but whether the AF subgroups defined in this way align with underlying mechanisms, such as high polygenic liability to AF or inflammation, and associate with clinical outcomes is unclear. METHODS: We identified individuals with AF in a large biobank linked to electronic health records (EHR) and genome-wide genotyping...
February 14, 2024: medRxiv
https://read.qxmd.com/read/38405652/left-atrial-diverticula-supplied-by-the-anomalistic-branch-of-the-right-coronary-artery
#28
Hidekazu Takeuchi
We have reported several cases of pulmonary vein thrombosis in elderly individuals with or without chest pain; pulmonary vein thrombosis is common in aged individuals and should be evaluated further. However, the properties and roles of pulmonary vein thrombi (PVTs) have not been determined. During infection, neutrophil extracellular traps (NETs) are produced to kill pathogens, and arterial thrombi (ATs) are produced in pulmonary veins to prevent pathogens from spreading to all organs. We reported that fine PVTs became larger PVTs and extended to the LA wall...
February 2024: Curēus
https://read.qxmd.com/read/38403938/blood-biomarkers-for-the-differentiation-between-central-and-peripheral-vertigo-in-the-emergency-department-a-systematic-review-and-meta-analysis
#29
REVIEW
Vincent W Klokman, Fiona N Koningstein, Job W W Dors, Marieke S Sanders, Sam W Koning, Dominique P V de Kleijn, Kim E Jie
BACKGROUND/INTRODUCTION: In patients with acute vestibular syndrome (AVS), differentiating between stroke and nonstroke causes is challenging in the emergency department (ED). Correct diagnosis of vertigo etiology is essential for early optimum treatment and disposition. OBJECTIVES: The aim of this systematic review and meta-analysis was to summarize the published evidence on the potential of blood biomarkers in the diagnosis and differentiation of peripheral from central causes of AVS...
February 25, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38403041/blocking-cerebral-lymphatic-system-reduces-central-and-peripheral-inflammatory-response-in-ischemic-stroke
#30
JOURNAL ARTICLE
Lingfei Yang, Qingsheng Li, Kaixin Wang, Huimin Liu, Xuan Yang, Yudi Xu, Yufei Chen, Junfang Teng, Zhe Gong, Yanjie Jia
Reduced blood supply to the brain activates the intracranial inflammatory response, a key contributor to secondary brain damage in ischemic stroke. Post-stroke, activation of peripheral immune cells leads to systemic inflammatory responses. Usingin vivo approaches, we investigated meningeal lymphatics' role in central immune cell infiltration and peripheral immune cell activation. The bilateral deep cervical lymph nodes (dCLNs) were removed 7 days before right middle cerebral artery occlusion in Sprague Dawley (SD) rats...
February 23, 2024: Brain Research
https://read.qxmd.com/read/38398069/long-term-outcomes-of-covid-19-in-hospitalized-type-2-diabetes-mellitus-patients
#31
JOURNAL ARTICLE
Zemfira Khamidullina, Diana Avzaletdinova, Diana Gareeva, Tatyana Morugova, Irina Lakman, Kristen Kopp, Lukas Fiedler, Lukas J Motloch, Naufal Zagidullin
UNLABELLED: With the onset of the coronavirus pandemic, it has become clear that patients with diabetes are at risk for more severe and fatal COVID-19. Type 2 diabetes mellitus (T2D) is a major risk factor for adverse COVID-19 outcomes. The goal of study was to assess the characteristics and outcomes of hospitalized patients with COVID-19 with or without T2D in the hospital and at 10-month follow-up (FU). METHODS: A total of 2486 hospitalized patients in the first wave of COVID-19 were analyzed according to the absence/presence of T2D, with 2082 (84...
February 19, 2024: Biomedicines
https://read.qxmd.com/read/38395685/prognostic-performance-of-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-for-mortality-in-patients-with-acute-stroke
#32
JOURNAL ARTICLE
R F Cáceda-Samamé, M R Vela-Salazar, R Alejandro-Salinas, A P Llamo-Vilcherrez, C J Toro-Huamanchumo
OBJECTIVE: To evaluate the prognostic performance of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) for mortality in patients with acute stroke treated at a Peruvian hospital. DESIGN: Retrospective cohort study. SETTING: Tertiary care hospital. PATIENTS: Patients aged ≥18 years with a diagnosis of acute stroke and admitted to the hospital from May 2019 to June 2021. INTERVENTIONS: None...
February 22, 2024: Hipertensión y Riesgo Vascular
https://read.qxmd.com/read/38395360/involvement-of-peptidylarginine-deiminase-4-in-eosinophil-extracellular-trap-formation-and-contribution-to-citrullinated-histone-signal-in-thrombi
#33
JOURNAL ARTICLE
Kimberly Martinod, Frederik Denorme, Severien Meyers, Marilena Crescente, Stijn Van Bruggen, Mathias Stroobants, Patrick M Siegel, Ramesh Grandhi, Katharina Glatz, Thilo Witsch
BACKGROUND: Extracellular traps formed by neutrophils (NETs) and eosinophils (EETs) have been described in coronary thrombi, contributing to thrombus stability. A key mechanism during NET formation is histone modification by the enzyme PAD4. Citrullinated histones, the product of PAD4 activity, are often attributed to neutrophils. Eosinophils also express high levels of PAD4 but the contribution of PAD4 to EET formation is not known. METHODS: We performed immunohistological analyses on thrombi, including a large, intact and eosinophil-containing thrombus retrieved from the right coronary artery using an aspiration catheter and stroke thrombi from thrombectomy retrieval...
February 21, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38390814/decoding-the-cell-atlas-and-inflammatory-features-of-human-intracranial-aneurysm-wall-by-single-cell-rna-sequencing
#34
JOURNAL ARTICLE
Hang Ji, Yue Li, Haogeng Sun, Ruiqi Chen, Ran Zhou, Yongbo Yang, Rong Wang, Chao You, Anqi Xiao, Liu Yi
BACKGROUND: Intracranial aneurysm (IA) is common and occasionally results in life-threatening hemorrhagic strokes. However, the cell architecture and inflammation in the IA dome remain less understood. METHODS AND RESULTS: Single-cell RNA sequencing was performed on ruptured and unruptured human IA domes for delineating the cell atlas, gene expression perturbations, and inflammation features. Two external bulk mRNA sequencing-based data sets and serological results of 126 patients were collected for validation...
February 23, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38386979/exacerbation-of-thrombo-inflammation-by-jak2v617f-mutation-worsens-the-prognosis-of-cerebral-venous-sinus-thrombosis
#35
JOURNAL ARTICLE
Marie-Charlotte Bourrienne, Véronique Le Cam Duchez, Dorothée Faille, Carine Farkh, Mialitiana Solo Nomenjanahary, Juliette Gay, Stéphane Loyau, Clément Journé, Sébastien Dupont, Véronique Ollivier, Jean-Luc J-L Villeval, Isabelle Plo, Valérie Edmond, Martine Jandrot-Perrus, Sylvie Labrouche-Colomer, Bruno Cassinat, Emmanuelle Verger, Jean-Philippe Desilles, Benoît Ho Ho Tin Noé, Aude Triquenot Bagan, Mikaël Mazighi, Nadine Ajzenberg
Cerebral venous sinus thrombosis (CVST) is an uncommon venous thromboembolic event accounting for <1% of strokes resulting in brain parenchymal injuries. JAK2V617F mutation, the most frequent driving mutation of myeloproliferative neoplasms has been reported to be associated with worse clinical outcomes in patients with CVST. We investigated whether hematopoietic JAK2V617F expression predisposes to specific pathophysiological processes and/or worse prognosis after CVST. Using an in vivo mouse model of CVST, we analyzed clinical, biological and imaging outcomes in mice with hematopoietic-restricted Jak2V617F expression, compared to Jak2WT mice...
February 22, 2024: Blood Advances
https://read.qxmd.com/read/38385697/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-with-headache-and-stroke-as-the-main-symptoms-a-case-report
#36
Xiaoyu Wu, Xiao Liu, Le Liu, Xiangqi Cao, Mengyuan Zhang, Sifan Wang, Meiying Deng, Guogang Luo, Qiumin Qu, Yitong Bian, Fude Liu, Jing Luo, Suhang Shang
No abstract text is available yet for this article.
February 22, 2024: Headache
https://read.qxmd.com/read/38384585/identification-of-hypoxia-and-immune-related-biomarkers-in-patients-with-ischemic-stroke
#37
JOURNAL ARTICLE
Haofuzi Zhang, Jidong Sun, Peng Zou, Yutao Huang, Qiuzi Yang, Zhuoyuan Zhang, Peng Luo, Xiaofan Jiang
BACKGROUND: The immune microenvironment and hypoxia play crucial roles in the pathophysiology of ischemic stroke (IS). Hence, in this study, we aimed to identify hypoxia- and immune-related biomarkers in IS. METHODS: The IS microarray dataset GSE16561 was examined to determine differentially expressed genes (DEGs) utilizing bioinformatics-based analysis. The intersection of hypoxia-related genes and DEGs was conducted to identify differentially expressed hypoxia-related genes (DEHRGs)...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38379112/advancing-stroke-therapy-a-deep-dive-into-early-phase-of-ischemic-stroke-and-recanalization
#38
REVIEW
Qianyan He, Yueqing Wang, Cheng Fang, Ziying Feng, Meifang Yin, Juyang Huang, Yinzhong Ma, Zhizhun Mo
Ischemic stroke, accounting for the majority of stroke events, significantly contributes to global morbidity and mortality. Vascular recanalization therapies, namely intravenous thrombolysis and mechanical thrombectomy, have emerged as critical interventions, yet their success hinges on timely application and patient-specific factors. This review focuses on the early phase pathophysiological mechanisms of ischemic stroke and the nuances of recanalization. It highlights the dual role of neutrophils in tissue damage and repair, and the critical involvement of the blood-brain barrier (BBB) in stroke outcomes...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38377019/neuron-derived-cold-inducible-rna-binding-protein-promotes-nets-formation-to-exacerbate-brain-endothelial-barrier-disruption-after-ischemic-stroke
#39
JOURNAL ARTICLE
Zhifang Li, Shuai Sun, Qinghui Xiao, Senwei Tan, Huijuan Jin, Bo Hu
In ischemic stroke, neutrophils are the first-line peripheral immune cells infiltrating the brain tissue to form neutrophil extracellular traps (NETs). The present study aimed to investigate the role of neuronal cold-inducible RNA-binding protein (CIRP) in promoting NETs-induced brain endothelial barrier destruction and cerebral edema after ischemic stroke. We found that the expression of NETs and neuronal CIRP in the penumbra increased at 6 hours after transient middle cerebral artery occlusion (tMCAO) and increased significantly at 24 hours, reaching a peak at 3 days...
February 9, 2024: Aging and Disease
https://read.qxmd.com/read/38376047/the-value-of-lp-a-and-tg-hdlc-in-peripheral-blood-to-assess-the-stability-of-carotid-plaque-in-patients-with-ischemic-stroke
#40
JOURNAL ARTICLE
Yanan Tian, Lei Lu, Yazhao Zhang, Jianhui Wei
OBJECTIVE: The objective of this study was to investigate the relationship between lipoprotein (a) (Lp(a)), triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), and the stability of carotid atherosclerotic plaque in patients with acute ischemic stroke. METHODS: A total of 142 patients with acute ischemic stroke were selected and divided into group A (59 cases of stable plaque formation) and group B (83 cases of unstable plaque formation) according to the characteristics of carotid artery plaque formation detected by carotid color Doppler ultrasound...
January 2024: Brain and Behavior
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