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Neutrophil stroke

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https://www.readbyqxmd.com/read/29929138/prothrombotic-mechanisms-in-patients-with-congenital-p-cys89tyr-mutation-in-cd59
#1
Adi Tabib, Issam Hindi, Netanel Karbian, Orly Zelig, Batla Falach, Dror Mevorach
BACKGROUND: Thrombosis is the prognostic factor with the greatest effect on survival in patients with paroxysmal nocturnal hemoglobinuria (PNH), who lack dozens of membrane surface proteins. We recently described a primary homozygous Cys89Tyr congenital nonfunctioning CD59 in humans with clinical manifestation in infancy, associated with chronic hemolysis, recurrent strokes, and relapsing peripheral demyelinating neuropathy. Here we investigated hypercoagulability mechanisms characterizing the syndrome...
June 11, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29916544/yc%C3%A2-1-reduces-inflammatory-responses-by-inhibiting-nuclear-factor%C3%A2-%C3%AE%C2%BAb-translocation-in-mice-subjected-to-transient-focal-cerebral-ischemia
#2
Wei-Ting Lee, Shih-Huang Tai, Yu-Wen Lin, Tian-Shung Wu, E-Jian Lee
3‑(5‑hydroxymethyl‑2‑furyl)‑1‑benzyl‑indazole (YC‑1) is understood to protect against ischemic stroke, but the molecular basis for its neuroprotection remains to be fully characterized. The present study investigated the influence of YC‑1 on inflammatory responses following experimental stroke. Previous studies indicated that nuclear factor (NF)‑κB‑driven signals serve a pivotal role in mediating inflammatory responses following stroke. Ischemic stroke results in activation of NF‑κB to induce gene expression of factors including inducible nitric oxide synthase, interleukin (IL)‑1β, IL‑6 and matrix metalloproteinases (MMPs)...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29895294/comparing-the-inflammatory-profiles-for-incidence-of-diabetes-mellitus-and-cardiovascular-diseases-a-prospective-study-exploring-the-common-soil-hypothesis
#3
Xue Bao, Yan Borné, Linda Johnson, Iram Faqir Muhammad, Margaretha Persson, Kaijun Niu, Gunnar Engström
BACKGROUND: Chronic low-grade inflammation and associated insulin resistance and metabolic abnormalities have been proposed as 'common soil' for diabetes mellitus (DM) and cardiovascular disease (CVD). This paper aimed to investigate the inflammatory profiles of DM and CVD and to distinguish their shared and specific markers. METHODS: Based on the Malmö Diet and Cancer cohort, total and differential leukocyte counts were measured in 25,969 participants without previous DM or CVD and were studied in relation to incident DM (mean follow-up 17...
June 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29892086/carotid-vulnerable-plaques-are-associated-with-circulating-leukocytes-in-acute-ischemic-stroke-patients-an-clinical-study-based-on-contrast-enhanced-ultrasound
#4
Zhaojun Li, Yun Bai, Wanbin Li, Feng Gao, Yi Kuang, Lianfang Du, Xianghong Luo
Inflammatory activity plays a central role in the development of carotid rupture-vulnerable atherosclerotic plaques, which is one of the major contributors to acute ischemic stroke. Our objective was to characterize carotid intraplaque neovascularizations (INP) using contrast-enhanced ultrasound (CEUS) and evaluate plaque burden through exploring the relationship between INP and cell count of peripheral leukocytes. Sixty-two patients with large artery atherosclerosis (LAA) were enrolled in this study. CEUS was performed to characterize the carotid artery plaques...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29885817/osteopontin-attenuates-inflammation-via-jak2-stat1-pathway-in-hyperglycemic-rats-after-intracerebral-hemorrhage
#5
Lei Gong, Anatol Manaenko, Ruiming Fan, Lei Huang, Budbazar Enkhjargal, DevinW McBride, Yan Ding, Jiping Tang, Xiaoqiu Xiao, John H Zhang
Acute intracerebral hemorrhage (ICH) complicated by hyperglycemia is associated with aggravation of post-stroke inflammation, leading to exacerbation of brain edema and predicting poor neurological outcomes and higher mortality of patients. Osteopontin (OPN) is a neuroprotective glycoprotein, which is able to attenuate brain injury induced by hemorrhagic stroke. In the current study we investigated whether OPN will decrease the inflammatory post-ICH response as well as attenuate brain edema and neurological deficits in hyperglycemic rats...
June 7, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29883691/anti-%C3%AE-2-gpi-%C3%AE-2-gpi-induces-neutrophil-extracellular-traps-formation-to-promote-thrombogenesis-via-the-tlr4-myd88-mapks-axis-activation
#6
Caijun Zha, Wenjing Zhang, Fei Gao, Jiali Xu, Ruichun Jia, Jinquan Cai, Yanhong Liu
Antiphospholipid antibodies (aPLs) are a large group of heterogeneous antibodies that bind to anionic phospholipids alone or in combination with phospholipid binding proteins. Increasing evidence has converged to indicate that aPLs especially anti-β2 glycoprotein I antibody (anti-β2 GPI) correlate with stroke severity and outcome. Though studies have shown that aPLs promote thrombus formation in a neutrophil-dependent way, the underlying mechanisms remain largely unknown. In the present study, we investigated the effect of anti-β2 GPI in complex with β2 GPI (anti-β2 GPI/β2 GPI) on neutrophil extracellular traps (NETs) formation and thrombus generation in vitro and in vivo...
June 5, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29882685/no-reflow-phenomenon-in-heart-and-brain
#7
Robert A Kloner, Kevin S King, Michael Harrington
The no-reflow phenomenon refers to the observation that when an organ is made ischemic by occlusion of a large artery supplying it, restoration of patency in that artery does not restore perfusion to the microvasculature supplying the parenchyma of that organ. This has been observed following prolonged arterial occlusions in the heart (30 to 90 minutes), brain, skin, and kidney. In experimental models, zones of no-reflow in the heart are characterized by ultrastructural microvascular damage, including focal endothelial swelling obstructing the lumen of small vessels...
June 8, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29803621/lipopolysaccharide-preconditioning-increased-the-level-of-regulatory-b-cells-in-the-spleen-after-acute-ischaemia-reperfusion-in-mice
#8
Zhe Wang, Yu Zhou, Yan Yu, Ke He, La-Mei Cheng
BACKGROUND: The inflammatory reaction of the spleen is an important component in the pathophysiology of cerebral ischaemia (CI). Regulatory B cells (Bregs) derived from the spleen can inhibit the expansion of inflammation and reduce the damage caused by CI. AIM: The aim of the present study was to explore changes in spleen function and Bregs production due to lipopolysaccharide preconditioning (LPS PC) in ischaemia/reperfusion (I/R) and to uncover potential protective effect of LPS PC on stroke...
May 24, 2018: Brain Research
https://www.readbyqxmd.com/read/29801037/association-of-neutrophil-to-lymphocyte-ratio-with-mortality-and-cardiovascular-disease-in-the-jackson-heart-study-and-modification-by-the-duffy-antigen-variant
#9
Stephanie Kim, Melissa Eliot, Devin C Koestler, Wen-Chih Wu, Karl T Kelsey
Importance: The neutrophil-to-lymphocyte ratio (NLR) is associated with mortality and cardiovascular disease at the time of incident disease, but it is not known whether this is true in prospective studies. Further, a common genetic variant of African origin associated with a relative neutropenia, the Duffy antigen variant, is a candidate to modify associations between NLR and outcomes. Objective: To investigate the association between NLR and mortality and cardiovascular-related outcomes in the Jackson Heart Study (JHS) and validated our findings in the Normative Aging Study (NAS)...
May 2, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29788103/post-ischaemic-administration-of-the-murine-canakinumab-surrogate-antibody-improves-outcome-in-experimental-stroke
#10
Luca Liberale, Candela Diaz-Cañestro, Nicole R Bonetti, Francesco Paneni, Alexander Akhmedov, Jürg H Beer, Fabrizio Montecucco, Thomas F Lüscher, Giovanni G Camici
Aims: The CANTOS trial underscored the efficacy of selective antibody-based interleukin (IL)-1β inhibition with Canakinumab in secondary prevention of cardiovascular events. Despite the success of the trial, incidence of stroke was not reduced likely due to the low number of events and the relatively young age of patients enrolled. Given the established role of IL-1β in stroke, we tested the efficacy of the murine Canakinumab-equivalent antibody in a mouse model of ischaemic stroke...
May 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29776451/myeloid-specific-tak1-deletion-results-in-reduced-brain-monocyte-infiltration-and-improved-outcomes-after-stroke
#11
Anjali Chauhan, Jacob Hudobenko, Abdullah Al Mamun, Edward C Koellhoffer, Anthony Patrizz, Rodney M Ritzel, Bhanu P Ganesh, Louise D McCullough
BACKGROUND: Activation of transforming growth factor-β-activated kinase 1 (TAK1) occurs after stroke and leads to an exacerbation of brain injury. TAK1 is involved in innate and adaptive immune responses, but it has divergent inflammatory effects that are dependent on the cell type in which it is activated. There is a robust infiltration of myeloid cells after stroke; however, the contribution of myeloid TAK1 to cerebral ischemia is currently unknown. We hypothesized that myeloid-specific deletion of TAK1 would protect against ischemic brain injury...
May 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29763889/neutrophil-lymphocyte-ratio-predicts-functional-and-safety-outcomes-after-endovascular-treatment-for-acute-ischemic-stroke
#12
Zhenhui Duan, Huaiming Wang, Zhen Wang, Yonggang Hao, Wenjie Zi, Dong Yang, Zhiming Zhou, Wenhua Liu, Min Lin, Zhonghua Shi, Penghua Lv, Yue Wan, Gelin Xu, Yunyun Xiong, Wusheng Zhu, Xinfeng Liu
BACKGROUND AND OBJECTIVE: Endovascular treatment (EVT) is proven to be safe and effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic stroke. This study aims to explore the relationship between NLR and the clinical outcomes of LVOS patients undergoing EVT. METHODS: Patients were selected from the EVT for acUte Anterior circuLation (ACTUAL) ischemic stroke registry...
May 15, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29752550/aging-alters-the-immunological-response-to-ischemic-stroke
#13
Rodney M Ritzel, Yun-Ju Lai, Joshua D Crapser, Anita R Patel, Anna Schrecengost, Jeremy M Grenier, Nickolas S Mancini, Anthony Patrizz, Evan R Jellison, Diego Morales-Scheihing, Venugopal R Venna, Julia K Kofler, Fudong Liu, Rajkumar Verma, Louise D McCullough
The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke; however, our understanding of these age-related changes is poor. In this work, we demonstrate marked differences in the composition of circulating and infiltrating leukocytes recruited to the ischemic brain of old male mice after stroke compared to young male mice. Blood neutrophilia and neutrophil invasion into the brain were increased in aged animals...
May 11, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29750575/unified-nexus-of-macrophages-and-maresins-in-cardiac-reparative-mechanisms
#14
Jeevan Kumar Jadapalli, Ganesh V Halade
Macrophages are immune-sensing "big eater" phagocytic cells responsible for an innate, adaptive, and regenerative response. After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the activation of the lipoxygenase-mediated maresin (MaR) metabolome at the site of ischemic injury. The specialized proresolving molecule and macrophage mediator in resolving inflammation, MaR-1, produced by human macrophages, has potent defining effects that limit polymorphonuclear neutrophil infiltration, enhance uptake of apoptotic PMNs, regulate inflammation resolution and tissue regeneration, and reduce pain...
May 11, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29743976/cell-type-specific-mechanisms-in-the-pathogenesis-of-ischemic-stroke-the-role-of-apoptosis-signal-regulating-kinase-1
#15
REVIEW
So Yeong Cheon, Eun Jung Kim, Jeong Min Kim, Bon-Nyeo Koo
Stroke has become a more common disease worldwide. Despite great efforts to develop treatment, little is known about ischemic stroke. Cerebral ischemia activates multiple cascades of cell type-specific pathomechanisms. Ischemic brain injury consists of a complex series of cellular reactions in various cell types within the central nervous system (CNS) including platelets, endothelial cells, astrocytes, neutrophils, microglia/macrophages, and neurons. Diverse cellular changes after ischemic injury are likely to induce cell death and tissue damage in the brain...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29729895/implications-of-polymorphonuclear-neutrophils-for-ischemic-stroke-and-intracerebral-hemorrhage-predictive-value-pathophysiological-consequences-and-utility-as-therapeutic-target
#16
REVIEW
Dirk M Hermann, Christoph Kleinschnitz, Matthias Gunzer
Polymorphonuclear neutrophil granulocytes (PMN) orchestrate the removal of cell debris in ischemic stroke and intracerebral hemorrhage. In both pathologies, high neutrophil to lymphocyte ratios in peripheral blood are predictive of poor outcome in human stroke patients. Following earlier studies indicating that the cerebral microvasculature forms an efficient barrier that impedes neutrophil brain entry, intravital microscopy and immunohistochemistry in the meantime unequivocally revealed the accumulation of PMN in the ischemic and hemorrhagic brain parenchyma...
April 24, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29724240/mesenchymal-stem-cells-attenuate-blood-brain-barrier-leakage-after-cerebral-ischemia-in-mice
#17
Zhuo Cheng, Liping Wang, Meijie Qu, Huaibin Liang, Wanlu Li, Yongfang Li, Lidong Deng, Zhijun Zhang, Guo-Yuan Yang
BACKGROUND: Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unknown. We therefore hypothesized that mesenchymal stem cells reduced blood-brain barrier destruction by inhibiting matrixmetallo-proteinase-9 and it was related to intercellular adhesion molecule-1 (ICAM-1)...
May 3, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29720539/it-s-reticulated-the-liver-at-the-heart-of-atherosclerosis
#18
REVIEW
Prabhakara R Nagareddy, Sunil K Noothi, Michelle C Flynn, Andrew J Murphy
Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications. Low-dose aspirin remains the mainstay of antiplatelet therapy in high-risk patients by reducing the risk of myocardial ischemia, stroke or death due to cardiovascular disease. However, antiplatelet therapies lose their efficacy in people with diabetes mellitus, increasing the risk of future atherothrombotic events. The molecular mechanisms that promote platelet hyperactivity remain unclear but could be due to glycation-induced conformational changes of platelet membranes resulting in impaired aspirin entry or less-efficient acetylation/compensatory increase in COX-2 expression in newborn platelets...
July 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29703010/biomarkers-of-gastric-cancer-related-ischemic-stroke-and-its-underlying-pathogenesis
#19
Haiyin Long, Kemin Qin, Jiyun Chen, Yicong Chen, Li Chen, Jinsheng Zeng, Zhijian Liang
This study aimed to investigate the biomarkers and underlying pathogenesis of ischemic stroke in patients with gastric cancer (GC).Patients with active gastric cancer who had experienced acute ischemic stroke without conventional vascular risk factors (gastric cancer-related stroke [GCS] group) and visited The First Affiliated Hospital of Guangxi Medical University and First Affiliated Hospital of Sun Yat-sen University from January 2003 to December 2016 were retrospectively enrolled. The patients' clinical features and laboratory findings were compared with those of age-, sex-, and disease progression-matched patients with GC without ischemic stroke (GC group) who had been admitted to the same hospital during the same period (GCS:GC ratio = 1:2)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29678934/neutrophil-counts-neutrophil-ratio-and-new-stroke-in-minor-ischemic-stroke-or-tia
#20
Bihong Zhu, Yuesong Pan, Jing Jing, Xia Meng, Xingquan Zhao, Liping Liu, David Wang, S Claiborne Johnston, Hao Li, Yilong Wang, Zhimin Wang, Yongjun Wang
OBJECTIVE: Evidence about whether neutrophil counts or neutrophil ratio is associated with new stroke is scant. The aim of this study is to assess the association of neutrophil counts or neutrophil ratio with a new stroke in patients with minor stroke or TIA. METHODS: We derived data from the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorized into 4 groups according to the quartile of neutrophil counts or neutrophil ratio...
May 22, 2018: Neurology
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