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Neutrophil stroke

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https://www.readbyqxmd.com/read/29227024/blood-biomarkers-as-predictors-of-long-term-mortality-in-copd
#1
Angelico Mendy, Erick Forno, Theophile Niyonsenga, Janvier Gasana
BACKGROUND: Blood biomarkers are easily accessible and might reflect chronic obstructive pulmonary disease (COPD) activity. AIM: To determine whether a panel of blood biomarkers (C-reactive protein [CRP], neutrophils, eosinophils, albumin and vitamin D) could predict mortality in COPD. METHODS: we analyzed data from 431 COPD participants to the 2007-2010 National Health and Nutrition Examination Surveys who were followed for a median time of 36 months...
December 11, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29212740/il-23-interleukin-23-producing-conventional-dendritic-cells-control-the-detrimental-il-17-interleukin-17-response-in-stroke
#2
Mathias Gelderblom, Mattia Gallizioli, Peter Ludewig, Vivien Thom, Priyadharshini Arunachalam, Björn Rissiek, Christian Bernreuther, Markus Glatzel, Thomas Korn, Thiruma Valavan Arumugam, Jan Sedlacik, Christian Gerloff, Eva Tolosa, Anna M Planas, Tim Magnus
BACKGROUND AND PURPOSE: Inflammatory mechanisms can exacerbate ischemic tissue damage and worsen clinical outcome in patients with stroke. Both αβ and γδ T cells are established mediators of tissue damage in stroke, and the role of dendritic cells (DCs) in inducing the early events of T cell activation and differentiation in stroke is not well understood. METHODS: In a murine model of experimental stroke, we defined the immune phenotype of infiltrating DC subsets based on flow cytometry of surface markers, the expression of ontogenetic markers, and cytokine levels...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29212188/baseline-platelet-parameters-for-predicting-early-platelet-response-and-clinical-outcomes-in-patients-with-non-cardioembolic-ischemic-stroke-treated-with-clopidogrel
#3
Wenxian Li, Xiaomei Xie, Di Wei, Shijun Zhang, Yuanling Wu, Xuejun Fu, Zhen Jing, Weibiao Lu, Xinqiang Lai, Li'an Huang
Purpose: The present study investigated whether routine baseline platelet parameters(BPPs) detected before clopidogrel therapy in acute non-cardioembolic ischemic stroke(NCIS) could predict early platelet response and future clinical outcomes. Results: The CYP2C19 polymorphisms constituted independent risk factors for LCR. The number of female patients, the incidence of diabetes mellitus (DM), the level of low-density lipoprotein(LDL) cholesterol, and the neutrophil-to-lymphocyte ratio(NLR) were significantly high in the clinical clopidogrel resistance (CCR) group...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209887/the-relationship-between-hematological-parameters-and-prognosis-of-children-with-acute-ischemic-stroke
#4
Ebru Yilmaz, Ayse Bayram Kacar, Adil Bozpolat, Gokmen Zararsiz, Burcu S Gorkem, Musa Karakukcu, Turkan Patiroglu, Hakan Gumus, Mehmet Akif Ozdemir, Alper Ozcan, Huseyin Per, Ekrem Unal
BACKGROUND: Stroke is rarely seen in children, but it is a major cause of morbidity and mortality. Therefore, there is a need for inexpensive and noninvasive diagnostic methods for estimating the prognosis. Although the prognostic importance of hematological parameters in acute ischemic stroke were reported in adult studies, there is a lack in pediatric ages. The aim of the study is to investigate the relationship between hematological parameters and prognosis of acute ischemic stroke in children...
December 5, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29195908/analysis-of-long-non-coding-rna-expression-profiles-following-focal-cerebral-ischemia-in-mice
#5
Cuiying Liu, Jian Yang, Chencheng Zhang, Menglei Liu, Xiaokun Geng, Xunming Ji, Huishan Du, Heng Zhao
Long noncoding RNAs (lncRNAs) have a variety of biological functions and play key roles in many diseases. However, the knowledge of lncRNA function during a stroke is limited. We analyzed the expression profiles of lncRNAs in the brain ischemic region of mice after a 45min middle cerebral artery occlusion (MCAO) with a 48h reperfusion. Gene ontology and pathway analysis were used to elucidate the potential functions of the differentially expressed mRNAs. A total of 255 lncRNAs (217 up-regulated and 38 down-regulated) and 894 mRNAs (870 up-regulated and 24 down-regulated) showed significantly altered expression in the ischemic brain compared to the sham controls (fold change ≫>2, P≪0...
November 28, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29195783/platelet-glycoprotein-receptor-ib-blockade-ameliorates-experimental-cerebral-ischemia-reperfusion-injury-by-strengthening-the-blood-brain-barrier-function-and-anti-thrombo-inflammatory-property
#6
Chunyan Chen, Tingting Li, Yuchen Zhao, Yinfeng Qian, Xiaoyi Li, Xiangrong Dai, Dake Huang, Tanzhong Pan, Lanlan Zhou
Blood-brain barrier (BBB) disruption, thrombus formation and immune-mediated inflammation are important steps in the pathophysiology of cerebral ischemia-reperfusion injury but are still inaccessible to therapeutic interventions. Recent studies have provided increasing evidence that blocking of platelet glycoprotein (GP) receptor Ib might represent a novel target in treating acute ischemic stroke. This research was conducted to explore the therapeutic efficacy and potential mechanisms of GPIba inhibitor (anfibatide) in a model of brain ischemia-reperfusion injury in mice...
November 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29177697/neuroprotective-and-anti-inflammatory-effects-of-a-dodecamer-peptide-harboring-ninjurin-1-cell-adhesion-motif-in-the-postischemic-brain
#7
Hye-Kyung Lee, Il-Doo Kim, Hahnbie Lee, Lidan Luo, Seung-Woo Kim, Ja-Kyeong Lee
It has been reported that the innate immune response plays important roles in brain ischemia and that the infiltration of blood-derived immune cells is a key initiator of this response. Nerve injury-induced protein 1 (Ninjurin 1, Ninj1) is a cell adhesion molecule responsible for cell-to-cell interactions between immune cells and endothelial cells. In the present study, we investigated the proinflammatory and neuroprotective effects of Ninj1 and a dodecamer peptide harboring Ninj1 N-terminal adhesion motif (N-NAM, Pro26~Asn37) in a rat middle cerebral artery occlusion (MCAO) model of stroke...
November 14, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29163837/the-use-of-neutrophil-to-lymphocyte-ratio-as-a-predictor-for-clinical-outcomes-in-spontaneous-intracerebral-hemorrhage
#8
Zengpanpan Ye, Xiaolin Ai, Fang Fang, Xin Hu, Andrew Faramand, Chao You
Objective: Neutrophil to lymphocyte ratio (NLR) is used as an independent predictor for clinical outcomes in cancers, cardiovascular disorders and ischemic stroke. The prognostic role of NLR in spontaneous intracerebral hemorrhage (sICH) is still controversial. The aim of this report is to conduct a meta-analysis to evaluate the prognostic significance NLR in patients with sICH. Materials and Methods: All related articles were searched on PubMed, EMBASE, Cochrane Central Register of Controlled Trials followed the PRISMA flow diagram...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137097/prognostic-role-of-neutrophil-lymphocyte-ratio-in-patients-with-acute-ischemic-stroke
#9
Jing Zhang, Qingqing Ren, Yanlin Song, Min He, Yunhui Zeng, Zhiyong Liu, Jianguo Xu
BACKGROUND: The aim of this study was to evaluate the prognostic role of neutrophil-lymphocyte ratio (NLR) in patients with acute ischemic stroke (AIS). METHODS: PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure were searched for potential eligible literature. The study characteristics and relevant data were extracted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of NLR in patients with AIS...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29111093/biomarkers-of-cerebral-microembolic-signals
#10
REVIEW
Ruihua Yin, Aijun Ma, Xudong Pan, Shaonan Yang
Stroke is a major cause of mortality and morbidity around the world. Microembolic signals (MES), as the markers of unstable atherosclerotic plaque, can predict the occurrence and prognosis of ischemic stroke (IS). MES can also assess the efficacy of antithrombotic agents and predict the recurrence probability of IS. Unstable plaques are the main source of MES; thus, numerous biomarkers of atherosclerotic plaque instability are highly likely to predict the presence of MES. This study aims to review recent biomarker candidates for MES or microembolism...
October 27, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29061727/aldosterone-target-ngal-neutrophil-gelatinase-associated-lipocalin-is-involved-in-cardiac-remodeling-after-myocardial-infarction-through-nf%C3%AE%C2%BAb-pathway
#11
Ernesto Martínez-Martínez, Mathieu Buonafine, Ines Boukhalfa, Jaime Ibarrola, Amaya Fernández-Celis, Peter Kolkhof, Patrick Rossignol, Nicolas Girerd, Paul Mulder, Natalia López-Andrés, Antoine Ouvrard-Pascaud, Frédéric Jaisser
Myocardial infarction (MI) is accompanied by cardiac fibrosis, which contributes to cardiac dysfunction. Mineralocorticoid receptor (MR) antagonists have beneficial effects in patients with left ventricular (LV) dysfunction after MI. We herein investigated the role of the MR target NGAL (neutrophil gelatinase-associated lipocalin) in post-MI cardiac damages. Both higher baseline NGAL and a greater increase in serum NGAL levels during follow-up were significantly associated with lower 6-month LV ejection fraction recovery in a cohort of 119 post-MI patients, as assessed by cardiac magnetic resonance imaging...
October 23, 2017: Hypertension
https://www.readbyqxmd.com/read/29056947/characteristics-of-elevated-cardiac-troponin-i-in-patients-with-acute-ischemic-stroke
#12
Yu-Xia Cui, Hui Ren, Chong-You Lee, Su-Fang Li, Jun-Xian Song, Xu-Guang Gao, Hong Chen
OBJECTIVE: To study prognostic characteristics of cardiac troponin I (cTnI) elevation in acute ischemic stroke. METHODS: We retrospectively studied patients (n = 248) with acute ischemic stroke, acute ST-segment elevation myocardial infarction, and acute non-ST-elevation myocardial infarction who were treated between January 2013 and October 2015. Baseline demographic data and changes in cTnI levels among these three groups were compared. Patients with acute ischemic stroke were assigned to either the cTnI elevation group (cTnI > 0...
June 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29039441/rivaroxaban-attenuates-thrombosis-by-targeting-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-a-rat-model-of-deep-venous-thrombus
#13
Junhao Ma, Xinxi Li, Yang Wang, Zhenwei Yang, Jun Luo
Anticoagulant therapy is commonly used for the prevention and treatment of patients with deep venous thrombus. Evidence has shown that rivaroxaban is a potential oral anticoagulant drug for the acute treatment of venous thromboembolism. However, the rivaroxaban-mediated molecular mechanism involved in the progression of deep venous thrombosis has not been investigated. In the present study, we investigated the efficacy of rivaroxaban and the underlying signaling pathways in the prevention and treatment of rats with deep venous thrombosis...
September 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28970514/effect-of-low-dose-alcohol-consumption-on-inflammation-following-transient-focal-cerebral-ischemia-in-rats
#14
Kimberly D McCarter, Chun Li, Zheng Jiang, Wei Lu, Hillary C Smith, Guodong Xu, William G Mayhan, Hong Sun
Increasing evidence suggest that low-dose alcohol consumption (LAC) reduces the incidence and improves the functional outcome of ischemic stroke. We determined the influence of LAC on post-ischemic inflammation. Male Sprague-Dawley rats were divided into 3 groups, an ethanol (13.5% alcohol) group, a red wine (Castle Rock Pinot Noir, 13.5% alcohol) group, and a control group. The amount of alcohol given to red wine and ethanol groups was 1.4 g/kg/day. After 8 weeks, the animals were subjected to a 2-hour middle cerebral artery occlusion (MCAO) and sacrificed at 24 hours of reperfusion...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927686/temporal-trends-in-the-levels-of-peripherally-circulating-leukocyte-subtypes-in-the-hours-after-ischemic-stroke
#15
Dipender Gill, Prasanthi Sivakumaran, Adarsh Aravind, Atisha Tank, Roshni Dosh, Roland Veltkamp
BACKGROUND: Leukocyte-mediated neuroinflammation may affect outcomes after ischemic stroke. AIMS: To explore temporal changes in levels of peripherally circulating leukocyte subtypes in the early hours after ischemic stroke in humans. METHODS: Retrospective analysis of a single-center database of consecutive thrombolysis cases for acute ischemic stroke (AIS). Multivariable regression analysis was used to explore temporal changes in the levels of peripherally circulating leukocyte subtypes in the hours immediately after ischemic stroke...
September 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28911981/peripheral-immune-cells-infiltrate-into-sites-of-secondary-neurodegeneration-after-ischemic-stroke
#16
K A Jones, S Maltby, M W Plank, M Kluge, M Nilsson, P S Foster, F R Walker
Experimental stroke leads to microglia activation and progressive neuronal loss at sites of secondary neurodegeneration (SND). These lesions are remote from, but synaptically connected to, primary infarction sites. Previous studies have demonstrated that immune cells are present in sites of infarction in the first hours and days after stroke, and are associated with increased neurodegeneration in peri-infarct regions. However, it is not known whether immune cells are also present in more distal sites where SND occurs...
January 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28865993/genetic-neutrophil-deficiency-ameliorates-cerebral-ischemia-reperfusion-injury
#17
Ryan A Frieler, Yutein Chung, Carolyn G Ahlers, George Gheordunescu, Jianrui Song, Thomas M Vigil, Yatrik M Shah, Richard M Mortensen
Neutrophils respond rapidly to cerebral ischemia and are thought to contribute to inflammation-mediated injury during stroke. Using myeloid Mcl1 knockout mice as a model of genetic neutrophil deficiency, we investigated the contribution of neutrophils to stroke pathophysiology. Myeloid Mcl1 knockout mice were subjected to transient middle cerebral artery occlusion and infarct size was assessed by MRI after 24h reperfusion. Immune cell mobilization and infiltration was assessed by flow cytometry. We found that myeloid Mcl1 knockout mice had significantly reduced infarct size when compared to heterozygous and wild type control mice (MyMcl1(+/+): 78...
December 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28837206/neutrophil-extracellular-traps-are-increased-in-patients-with-acute-ischemic-stroke-prognostic-significance
#18
Juana Vallés, Aída Lago, María Teresa Santos, Ana María Latorre, José I Tembl, Juan B Salom, Candela Nieves, Antonio Moscardó
Neutrophil extracellular traps (NETs) are networks of DNA, histones, and proteolytic enzymes produced by activated neutrophils through different mechanisms. NET formation is promoted by activated platelets and can in turn activate platelets, thus favoring thrombotic processes. NETs have been detected in venous and arterial thrombosis, but data in stroke are scarce. The aim of this study was to evaluate NETs in the plasma of patients with acute ischemic stroke and their potential association with baseline clinical characteristics, stroke severity, and one-year clinical outcomes...
October 5, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28834908/association-of-lymphocyte-to-monocyte-ratio-with-in-hospital-and-long-term-major-adverse-cardiac-and-cerebrovascular-events-in-patients-with-st-elevated-myocardial-infarction
#19
Qian Wang, Junfen Ma, Zhiyun Jiang, Fan Wu, Jiedan Ping, Liang Ming
In recent years, lymphocyte-to-monocyte ratio (LMR) has become a novel indirect marker of inflammation, which has been demonstrated to be associated with poor prognosis of oncology and cardiovascular disease. The aim of the study was to assess the relationship between LMR on admission and in-hospital and long-term major adverse cardiac and cerebrovascular events (MACCE) in patients with ST-elevated myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI).A total of 306 STEMI patients were enrolled and grouped according to tertiles of LMR from the blood samples obtained in the emergency room on admission...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28829826/elevated-neutrophil-to-lymphocyte-ratio-and-ischemic-stroke-risk-in-generally-healthy-adults
#20
Beomseok Suh, Dong Wook Shin, Hyung-Min Kwon, Jae Moon Yun, Hyung-Kook Yang, Eunmi Ahn, Hyejin Lee, Jin Ho Park, BeLong Cho
Elevated neutrophil to lymphocyte ratio (NLR) has been reported as a marker for chronic inflammation, associated with poor prognosis in ischemic stroke patients, but there has been no study that investigated its association with ischemic stroke risk. This study was conducted to investigate elevated NLR as an independent risk factor for ischemic stroke incidence. Our retrospective cohort study included 24,708 generally healthy subjects aged 30-75 who received self-referred health screening at Seoul National University Hospital...
2017: PloS One
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