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https://www.readbyqxmd.com/read/28724279/alterations-in-striatal-circuits-underlying-addiction-like-behaviors
#1
REVIEW
Hyun Jin Kim, Joo Han Lee, Kyunghwa Yun, Joung-Hun Kim
Drug addiction is a severe psychiatric disorder characterized by the compulsive pursuit of drugs of abuse despite potential adverse consequences. Although several decades of studies have revealed that psychostimulant use can result in extensive alterations of neural circuits and physiology, no effective therapeutic strategies or medicines for drug addiction currently exist. Changes in neuronal connectivity and regulation occurring after repeated drug exposure contribute to addiction-like behaviors in animal models...
June 30, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28724272/patients-characteristics-histopathological-findings-and-tumor-stage-in-different-types-of-malignant-melanoma-a-retrospective-multicenter-study
#2
Ali-Mohammad Farahmand, Amir-Hoshang Ehsani, Mojtaba Mirzaei, Maryam Mohsenian, Alireza Ghanadan
Cutaneous malignant melanoma (CMM) is currently the most fatal of skin cancers accounting for 50000 deaths annually. Five distinct melanomas are described histopathologically: superficial spreading, lentigo maligna, nodular, acral lentiginous and mucosal melanoma. The aim of this study was to investigate the characteristics of patients with various types of malignant melanoma and evaluate histopathological findings. In this retrospective study, we obtained our data from the records of 111 patients with melanoma...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28724249/occurrence-and-source-apportionment-of-atmospheric-halogenated-flame-retardants-in-lhasa-city-in-the-tibetan-plateau-china
#3
Wan-Li Ma, Wen-Long Li, Zi-Feng Zhang, Li-Yan Liu, Wei-Wei Song, Chun-Yan Huo, Yi-Xing Yuan, Yi-Fan Li
Active air samples were collected in Lhasa, one of the highest cities in the world (3650m above sea level) located in the Tibetan Plateau, and were analyzed for 38 halogenated flame retardants (HFRs), including polybrominated diphenyl ethers (PBDEs), non-PBDE brominated flame retardants (NBFRs) and dechlorane plus (DPs). The median concentrations of PBDEs, NBFRs and DPs were 40, 23 and 0.21pg/m(3), respectively. Correlation analysis indicated the common source and/or similar environmental behavior for several HFRs...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724228/a-new-method-for-correlation-analysis-of-compositional-environmental-data-a-worked-example
#4
C Reimann, P Filzmoser, K Hron, P Kynčlová, R G Garrett
Most data in environmental sciences and geochemistry are compositional. Already the unit used to report the data (e.g., μg/l, mg/kg, wt%) implies that the analytical results for each element are not free to vary independently of the other measured variables. This is often neglected in statistical analysis, where a simple log-transformation of the single variables is insufficient to put the data into an acceptable geometry. This is also important for bivariate data analysis and for correlation analysis, for which the data need to be appropriately log-ratio transformed...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724224/assessing-natural-and-anthropogenic-influences-on-water-discharge-and-sediment-load-in-the-yangtze-river-china
#5
Yifei Zhao, Xinqing Zou, Qing Liu, Yulong Yao, Yali Li, Xiaowei Wu, Chenglong Wang, Wenwen Yu, Teng Wang
The water discharge and sediment load of rivers are changing substantially under the impacts of climate change and human activities, becoming a hot issue in hydro-environmental research. In this study, the water discharge and sediment load in the mainstream and seven tributaries of the Yangtze River were investigated by using long-term hydro-meteorological data from 1953 to 2013. The non-parametric Mann-Kendall test and double mass curve (DMC) were used to detect trends and abrupt change-points in water discharge and sediment load and to quantify the effects of climate change and human activities on water discharge and sediment load...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724219/forecasting-pm2-5-induced-male-lung-cancer-morbidity-in-china-using-satellite-retrieved-pm2-5-and-spatial-analysis
#6
Xiao Han, Yuqin Liu, Hong Gao, Jianmin Ma, Xiaoxuan Mao, Yuting Wang, Xudong Ma
The present study predicts a spatial distribution of lung cancer morbidity in Chinese males due to exposure to PM2.5 concentration from 2010 to 2015. A spatial autocorrelation method was used to evaluate the spatial relationship between the lung cancer morbidities from 2006 to 2009 and satellite-derived PM2.5 atmospheric levels. A comprehensive grey correlation degree analysis was carried out to assess the simultaneous and lag associations between the lung cancer morbidity and PM2.5 concentration. These relationships were subsequently applied to predict male lung cancer morbidity in a specific year...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724151/assessment-of-addiction-medicine-training-in-family-medicine-residency-programs-a-cera-study
#7
Sebastian Tong, Roy Sabo, Rebecca Aycock, Ramakrishna Prasad, Rebecca Etz, Anton Kuzel, Alex Krist
BACKGROUND AND OBJECTIVES: Substance use disorder (SUD) is a widespread problem but physicians may feel inadequately prepared to provide addiction care. We sought to assess current addiction medicine curricula in US family medicine residencies (FMRs) and evaluate barriers to improving or implementing addiction medicine curricula. METHODS: Questions regarding addiction medicine training were added to the December 2015 Council of Academic Family Medicine Educational Research Alliance (CERA) survey to US FMR program directors to evaluate each FMR's curriculum, potential workforce production, perceived barriers to improving or implementing curricula and faculty training in addiction medicine...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724133/a-nationwide-analysis-of-cost-variation-for-autologous-free-flap-breast-reconstruction
#8
Jessica I Billig, Yiwen Lu, Adeyiza O Momoh, Kevin C Chung
Importance: Cost variation among hospitals has been demonstrated for surgical procedures. Uncovering these differences has helped guide measures taken to reduce health care spending. To date, the fiscal consequence of hospital variation for autologous free flap breast reconstruction is unknown. Objective: To investigate factors that influence cost variation for autologous free flap breast reconstruction. Design, Setting, and Participants: A secondary cross-sectional analysis was performed using the Healthcare Cost and Utilization Project National Inpatient Sample database from 2008 to 2010...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28724122/association-between-patient-age-and-lymph-node-positivity-in-thin-melanoma
#9
Andrew J Sinnamon, Madalyn G Neuwirth, Pratyusha Yalamanchi, Phyllis Gimotty, David E Elder, Xiaowei Xu, Rachel R Kelz, Robert E Roses, Emily Y Chu, Michael E Ming, Douglas L Fraker, Giorgos C Karakousis
Importance: More than half of all new melanoma diagnoses present as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in this population given the overall low yield. Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, are not routinely considered. Objectives: To identify indicators of lymph node (LN) metastasis in thin melanoma in a large, generalizable data set and to evaluate the association between patient age and LN positivity...
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28724108/yellow-perch-perca-flavescens-mercury-unaffected-by-wildland-fires-in-northern-minnesota
#10
Charlotte E Riggs, Randall K Kolka, Edward A Nater, Emma L Witt, Trent R Wickman, Laurel G Woodruff, Jason T Butcher
Wildland fire can alter mercury (Hg) cycling on land and in adjacent aquatic environments. In addition to enhancing local atmospheric Hg redeposition, fire can influence terrestrial movement of Hg and other elements into lakes via runoff from burned upland soil. However, the impact of fire on water quality and the accumulation of Hg in fish remain equivocal. We investigated the effects of fire-specifically, a low-severity prescribed fire and moderate-severity wildfire-on young-of-the-year yellow perch () and lake chemistry in a small remote watershed in the Boundary Waters Canoe Area Wilderness in northeastern Minnesota...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724101/assessment-of-the-effects-of-total-emission-control-policies-on-surface-water-quality-in-china-2004-to-2014
#11
Xia Liu, Jianfeng Feng, Yinhuan Qiao, Yuqiu Wang, Lin Zhu
Water quality deterioration is a problem throughout the globe, especially in China. The Chinese government established national total emission control (TEC) policies related to the nation's surface water quality over the past 10 yr to restore, protect, and promote healthy water quality. The objective of this study is to evaluate the effects of China's TEC policies by analyzing three water quality constituents (ammonium nitrogen [NH-N], dissolved oxygen [DO], and the permanganate index [COD]) at 73 monitoring stations, which account for most of the surface waters of eastern China...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724093/persistence-of-ascaris-spp-ova-in-tropical-soil-cultivated-with-eucalyptus-and-fertilized-with-municipal-biosolids
#12
Marianne F de Faria, Iraê A Guerrini, Fernando C Oliveira, Maria Inês Z Sato, Elayse M Hachich, José Raimundo S Passos, Lívia M L Goulart, Thiago T de S Silva, José L Gava, Joel C Furches, Jason James, Robert B Harrison
In many countries, the main reason for severely restricting or outright banning the land application of class B biosolids is the lack of risk assessment for adverse human health impacts. Among pathogens that are not often studied are helminth ova, including that of the spp. Almost all of the knowledge about the persistence of spp. ova in soils fertilized with biosolids is based on studies developed in North America, Europe, and Asia. These studies have almost always been conducted under temperate climate conditions, which may cause erroneous interpretations when the conclusions are extrapolated to tropical regions such as those found in Brazil...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724089/grower-analysis-of-organic-matter-amendments-in-california-orchards
#13
Sat Darshan S Khalsa, Patrick H Brown
Organic matter amendments supply crop nutrients and enhance soil health, yet information specific to orchards is lacking. A survey was conducted to analyze use of these materials by California almond [ (Mill.) D.A. Webb] growers. Significant differences were observed for benefits, concerns, and accessibility to manure and green waste sources and between users and nonusers. Use patterns were significantly influenced by heavy and light users, farm size, and geographic region. Enhanced soil biology was the main benefit attributed to organic matter amendments by both users and nonusers...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724083/identification-of-candidate-genes-responsible-for-stem-pith-production-using-expression-analysis-in-solid-stemmed-wheat
#14
A J Oiestad, J M Martin, J Cook, A C Varella, M J Giroux
The wheat stem sawfly (WSS) is an economically important pest of wheat in the Northern Great Plains. The primary means of WSS control is resistance associated with the single quantitative trait locus (QTL) , which controls most stem solidness variation. The goal of this study was to identify stem solidness candidate genes via RNA-seq. This study made use of 28 single nucleotide polymorphism (SNP) makers derived from expressed sequence tags (ESTs) linked to contained within a 5.13 cM region. Allele specific expression of EST markers was examined in stem tissue for solid and hollow-stemmed pairs of two spring wheat near isogenic lines (NILs) differing for the QTL...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724080/qtls-associated-with-crown-root-angle-stomatal-conductance-and-maturity-in-sorghum
#15
Jose R Lopez, John E Erickson, Patricio Munoz, Ana Saballos, Terry J Felderhoff, Wilfred Vermerris
Three factors that directly affect the water inputs in cropping systems are root architecture, length of the growing season, and stomatal conductance to water vapor (). Deeper-rooted cultivars will perform better under water-limited conditions because they can access water stored deeper in the soil profile. Reduced limits transpiration rate () and thus throughout the vegetative phase conserves water that may be used during grain filling in water-limited environments. Additionally, growing early-maturing varieties in regions that rely on soil-stored water is a key water management strategy...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724076/gbs-based-genomic-selection-for-pea-grain-yield-under-severe-terminal-drought
#16
Paolo Annicchiarico, Nelson Nazzicari, Luciano Pecetti, Massimo Romani, Barbara Ferrari, Yanling Wei, E Charles Brummer
Terminal drought is the main stress that limits pea ( L.) grain yield in Mediterranean-climate regions. This study provides an unprecedented assessment of the predictive ability of genomic selection (GS) for grain yield under severe terminal drought using genotyping-by-sequencing (GBS) data. Additional aims were to assess the GS predictive ability for different GBS data quality filters and GS models, comparing intrapopulation with interpopulation GS predictive ability and to perform genome-wide association (GWAS) studies...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724074/high-resolution-genetic-and-physical-mapping-of-the-eastern-filbert-blight-resistance-region-in-jefferson-hazelnut-corylus-avellana-l
#17
Vidyasagar Sathuvalli, Shawn A Mehlenbacher, David C Smith
Eastern filbert blight (EFB), caused by the pyrenomycete (Peck) E. Müller, is a devastating disease of European hazelnut ( L) in the US Pacific Northwest. A dominant allele at a single locus from the obsolete pollenizer 'Gasaway' confers a high level of resistance to EFB. To identify the gene responsible for resistance, we initiated map-based cloning efforts in a population of 1488 seedlings that segregated for resistance. Chromosome walking was initiated using primers designed from eight previously identified random amplified polymorphic DNA markers linked to resistance...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724069/a-distinct-genetic-cluster-in-cultivated-chickpea-as-revealed-by-genome-wide-marker-discovery-and-genotyping
#18
Stefano Pavan, Concetta Lotti, Angelo R Marcotrigiano, Rosa Mazzeo, Nicoletta Bardaro, Valentina Bracuto, Francesca Ricciardi, Francesca Taranto, Nunzio D'Agostino, Adalgisa Schiavulli, Claudio De Giovanni, Cinzia Montemurro, Gabriella Sonnante, Luigi Ricciardi
The accurate description of plant biodiversity is of utmost importance to efficiently address efforts in conservation genetics and breeding. Herein, we report the successful application of a genotyping-by-sequencing (GBS) approach in chickpea ( L.), resulting in the characterization of a cultivated germplasm collection with 3187 high-quality single nucleotide polymorphism (SNP) markers. Genetic structure inference, principal component analysis, and hierarchical clustering all indicated the identification of a genetic cluster corresponding to black-seeded genotypes traditionally cultivated in Southern Italy...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724068/genome-wide-association-mapping-of-qualitatively-inherited-traits-in-a-germplasm-collection
#19
Nonoy B Bandillo, Aaron J Lorenz, George L Graef, Diego Jarquin, David L Hyten, Randall L Nelson, James E Specht
Genome-wide association (GWA) has been used as a tool for dissecting the genetic architecture of quantitatively inherited traits. We demonstrate here that GWA can also be highly useful for detecting many major genes governing categorically defined phenotype variants that exist for qualitatively inherited traits in a germplasm collection. Genome-wide association mapping was applied to categorical phenotypic data available for 10 descriptive traits in a collection of ∼13,000 soybean [ (L.) Merr.] accessions that had been genotyped with a 50,000 single nucleotide polymorphism (SNP) chip...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724064/genetic-characterization-of-the-soybean-nested-association-mapping-population
#20
Qijian Song, Long Yan, Charles Quigley, Brandon D Jordan, Edward Fickus, Steve Schroeder, Bao-Hua Song, Yong-Qiang Charles An, David Hyten, Randall Nelson, Katy Rainey, William D Beavis, Jim Specht, Brian Diers, Perry Cregan
A set of nested association mapping (NAM) families was developed by crossing 40 diverse soybean [ (L.) Merr.] genotypes to the common cultivar. The 41 parents were deeply sequenced for SNP discovery. Based on the polymorphism of the single-nucleotide polymorphisms (SNPs) and other selection criteria, a set of SNPs was selected to be included in the SoyNAM6K BeadChip for genotyping the parents and 5600 RILs from the 40 families. Analysis of the SNP profiles of the RILs showed a low average recombination rate...
July 2017: Plant Genome
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