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https://www.readbyqxmd.com/read/29356463/spatial-barriers-impact-upon-appropriate-delivery-of-radiotherapy-in-breast-cancer-patients
#1
Fabrizio Stracci, Fortunato Bianconi, Chiara Lupi, Manuela Margaritelli, Alessio Gili, Cynthia Aristei
Radiotherapy (RT) is the standard treatment for breast cancer patients after conserving surgery or mastectomy when patients are at high risk of relapse. Major obstacles to appropriate RT delivery are journey times. Since studies on access to RT were carried out mostly in large countries, this study investigated factors in an Italian region and the influence of RT delivery on survival. A total of 4735 female candidates for RT were included in the study. A geographic information system calculated journey times from patients' homes and surgery hospitals to RT centers...
January 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29356454/correlates-of-immune-defenses-in-golden-eagle-nestlings
#2
Elisabeth MacColl, Kris Vanesky, Jeremy A Buck, Benjamin M Dudek, Collin A Eagles-Smith, Julie A Heath, Garth Herring, Chris Vennum, Cynthia J Downs
An individual's investment in constitutive immune defenses depends on both intrinsic and extrinsic factors. We examined how Leucocytozoon parasite presence, body condition (scaled mass), heterophil-to-lymphocyte (H:L) ratio, sex, and age affected immune defenses in golden eagle (Aquila chrysaetos) nestlings from three regions: California, Oregon, and Idaho. We quantified hemolytic-complement activity and bacterial killing ability, two measures of constitutive immunity. Body condition and age did not affect immune defenses...
June 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356451/gene-encoding-the-ctp-synthetase-as-an-appropriate-molecular-tool-for-identification-and-phylogenetic-study-of-the-family-bifidobacteriaceae
#3
Jiří Killer, Chahrazed Mekadim, Radko Pechar, Věra Bunešová, Jakub Mrázek, Eva Vlková
An alternative molecular marker with respect to the 16S rRNA gene demonstrating better identification and phylogenetic parameters has not been designed for the whole Bifidobacteriaceae family, which includes the genus Bifidobacterium and scardovial genera. Therefore, the aim of the study was to find such a gene in available genomic sequences, suggest appropriate means and conditions for asmplification and sequencing of the desired region of the selected gene in various strains of the bacterial family and verify the importance in classification and phylogeny...
January 22, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29356406/origin-of-sex-chromosomes-in-six-groups-of-rana-rugosa-frogs-inferred-from-a-sex-linked-dna-marker
#4
Akira Oike, Koichiro Watanabe, Mi-Sook Min, Koji Tojo, Masahide Kumagai, Yuya Kimoto, Tadashi Yamashiro, Takanori Matsuo, Maho Kodama, Yoriko Nakamura, Masaru Notsu, Takeyoshi Tochimoto, Hiroyuki Fujita, Maki Ota, Etsuro Ito, Shigeki Yasumasu, Masahisa Nakamura
Each vertebrate species, as a general rule, has either the XX/XY or ZZ/ZW chromosomes by which sex is determined. However, the Japanese Rana (R.) rugosa frog is an exception, possessing both sex-determining combinations within one species, varying with region of origin. We collected R. rugosa frogs from 104 sites around Japan and South Korea and determined the nucleotide sequences of the mitochondrial 12S ribosomal RNA gene. Based on the sequences, R. rugosa frogs were divided into four groups from Japan and one from South Korea...
August 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356390/adherence-to-antiretroviral-therapy-for-hiv-aids-in-latin-america-and-the-caribbean-systematic-review-and-meta-analysis
#5
REVIEW
Jessica de Mattos Costa, Thiago Silva Torres, Lara Esteves Coelho, Paula Mendes Luz
INTRODUCTION: Optimal adherence to antiretroviral therapy is closely related with suppression of the HIV viral load in plasma, slowing disease progression and decreasing HIV transmission rates. Despite its importance, the estimated proportion of people living with HIV in Latin America and the Caribbean with optimal adherence has not yet been reported in a meta-analysis. Moreover, little is known of the factors leading to poor adherence which may be setting-specific. We present a pooled estimate of adherence to antiretroviral therapy (ART) of people living with HIV in Latin America and Caribbean, report the methods used to measure adherence and describe the factors associated with poor adherence among the selected studies...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29356375/molecular-characterization-and-tissue-expression-profiles-of-prepro-vasoactive-intestinal-peptide-in-the-chinese-alligator-alligator-sinensis-during-the-active-and-hibernating-periods
#6
Sheng-Zhou Zhang, Ting Meng, Xue Zhu, Huan Wang, Yong-Kang Zhou, Xiao-Bing Wu
The Chinese alligator (Alligator sinensis), a freshwater crocodilian endemic to China, is one of the most endangered crocodilian species; up to this date, very little is known about the endocrine regulation of its metabolic activities during different physiological states. In this study, we characterized the structure of the prepro-vasoactive intestinal peptide in Chinese alligator (prepro-caVIP) for the first time and examined its expression profiles in various tissues during the active and hibernating periods...
February 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356343/metataxonomic-approach-to-decipher-the-polymicrobial-burden-in-diabetic-foot-ulcer-and-its-biofilm-mode-of-infection
#7
Karthika Suryaletha, Joby John, Megha Periyappilly Radhakrishnan, Sanil George, Sabu Thomas
Chronic diabetic foot is a global burden affecting millions of people, and the chronicity of an ulcer is directly linked to the diverse bacterial burden and its biofilm mode of infection. The bacterial diversity of 100 chronic diabetic ulcer samples was profiled via traditional culturing method as well as metagenomic approach by sequencing the 16S rRNA V3 hyper-variable region on Illumina Miseq Platform (Illumina, Inc., San Diego, CA). All the relevant clinical metadata, including duration of diabetes, grade of ulcer, presence of neuropathy, and glycaemic level, were noted and correlated with the microbiota...
January 22, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29356279/on-the-synthesis-of-chocolate-flavonoids-propanols-butanals-in-the-interstellar-medium
#8
Matthew James Abplanalp, Sándor Góbi, Alexandre Bergantini, Andrew M Turner, Ralf I Kaiser
Complex organic molecules are ubiquitous in star- and planet-forming regions as well as on comets such as on 67P/Churyumov-Gerasimenko, but their origins have remained largely unexplained until now. Here, we report the first laboratory detection of distinct C3H8O (propanol, methyl ethyl ether) and C4H8O (n-butanal, i-butanal) isomers formed within interstellar analog ices through interaction with ionizing radiation. This study reveals that complex organics with propyl (C3H7) and butyl (C4H9) groups can be synthesized easily in deep space and may act as key evolutionary tracers of a cosmic ray driven non-equilibrium chemistry in low temperature interstellar ices at 10 K...
January 22, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29356243/major-limitations-to-achieving-4-per-1000%C3%A2-increases-in-soil-organic-carbon-stock-in-temperate-regions-evidence-from-long-term-experiments-at-rothamsted-research-uk
#9
Paul Poulton, Johnny Johnston, Andy MacDonald, Rodger White, David Powlson
We evaluated the "4 per 1000″ initiative for increasing soil organic carbon (SOC) by analysing rates of SOC increase in treatments in 16 long-term experiments in south-east UK. The initiative sets a goal for SOC stock to increase by 4‰ yr-1 in the 0-40 cm soil depth, continued over 20 years. Our experiments, on 3 soil types, provided 114 treatment comparisons over 7-157 years. Treatments included organic additions (incorporated by inversion ploughing), N fertilizers, introducing pasture leys into continuous arable systems, and converting arable land to woodland...
January 21, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29356242/preferable-in-vitro-condition-for-maintaining-faithful-dna-methylation-imprinting-in-mouse-embryonic-stem-cells
#10
Jiyoung Lee, Ayumi Matsuzawa, Hirosuke Shiura, Akito Sutani, Fumitoshi Ishino
Epigenetic properties of cultured embryonic stem cells (ESCs), including DNA methylation imprinting, are important because they affect the developmental potential. Here, we tested a variety of culture media, including knockout serum replacement (KSR) and fetal bovine serum (FBS) with or without inhibitors of Gsk3β and Mek1/2 (2i) at various time points. In addition to the previously known passage-dependent global changes, unexpected dynamic DNA methylation changes occurred in both maternal and paternal differentially methylated regions: under the widely used condition of KSR with 2i, a highly hypomethylated state occurred at early passages (P1-7) as well as P10, but DNA methylation increased over further passages in most conditions, except under KSR with 2i at P25...
January 22, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29356240/seroprevalence-of-leptospira-antibodies-among-market-workers-and-food-handlers-in-the-central-state-of-malaysia
#11
S Suhailah, S N S Sakinah, O Malina, B A Norliza, N M Asyraf, A Fairuz, T Z M T Jamaluddin, A H Rukman, W M Zahiruddin, M N Shafei, S Surianti, B D Aziah, I Zawaha, A W Zainudin, N A Munirah, M N Desa, V Neela, S M Norbaya
OBJECTIVE: The high prevalence of leptospirosis in humans is of great public health concern, particularly in tropical and subtropical regions. This study aimed to determine the seroprevalence of Leptospira antibodies and distribution of serovars, and to assess the usefulness of enzyme-linked immunosorbent assay (ELISA) as a screening method for leptospiral antibodies in a high-risk healthy community. METHODS: Cross-sectional study of 231 market workers and food handlers in wet markets and food premises from two localities in central Malaysia...
January 22, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29356230/maternal-and-child-health-nurses-work-with-refugee-families-perspectives-from-regional-victoria-australia
#12
Suzanne M Willey, Robyn P Cant, Allison Williams, Meredith McIntyre
AIMS AND OBJECTIVES: This study aimed to explore service provision for Victorian regional refugee families from the perspective of Maternal and Child Health nurses. BACKGROUND: Increasingly, more families from a refugee background are resettling in regional Victoria. The refugee journey has significant effect on families. Refugee families with infants and young children can be provided with support by Maternal and Child Health services; however, many families experience barriers to ongoing engagement with this service...
January 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29356213/a-multi-parent-advanced-generation-inter-cross-magic-population-for-genetic-analysis-and-improvement-of-cowpea-vigna-unguiculata-l-walp
#13
Bao-Lam Huynh, Jeffrey D Ehlers, Bevan Emma Huang, Maria Munoz-Amatriain, Stefano Lonardi, Jansen R P Santos, Arsenio Ndeve, Benoit J Batieno, Ousmane Boukar, Ndiaga Cisse, Issa Drabo, Christian Fatokun, Francis Kusi, Richard Y Agyare, Yi-Ning Guo, Ira Herniter, Sassoum Lo, Steve I Wanamaker, Shizhong Xu, Timothy J Close, Philip A Roberts
Multi-parent Advanced Generation Inter-Cross (MAGIC) populations are an emerging type of resource to dissect the genetic structure of traits and improve breeding populations. We developed a MAGIC population for cowpea (Vigna unguiculata L. Walp.) from eight founder parents which are genetically diverse and carry many abiotic and biotic stress resistance, seed quality and agronomic traits relevant to cowpea improvement in the USA and sub-Saharan Africa, where cowpea is vitally important in the human diet and local economies...
January 21, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29356210/clinical-course-and-prognostic-factors-across-different-musculoskeletal-pain-sites-a-secondary-analysis-of-individual-patient-data-from-randomised-clinical-trials
#14
D J Green, M Lewis, G Mansell, M Artus, K S Dziedzic, E M Hay, N E Foster, D A van der Windt
BACKGROUND: Previous research has identified similar prognostic factors in patients with musculoskeletal (MSK) conditions regardless of pain presentation, generating opportunities for management based on prognosis rather than specific pain presentation. METHODS: Data from seven RCTs (2,483 participants) evaluating a range of primary care interventions for different MSK pain conditions were used to investigate the course of symptoms and explore similarities and differences in predictors of outcome...
January 22, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29356205/antiviral-potential-of-medicinal-plants-against-hiv-hsv-influenza-hepatitis-and-coxsackievirus-a-systematic-review
#15
REVIEW
Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections...
January 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29356186/the-blomia-tropicalis-allergen-blo-t-7-stimulates-innate-immune-signaling-pathways-through-tlr2
#16
Tewarit Soongrung, Karntichar Mongkorntanyatipa, Termsri Peepim, Arun Buaklin, Maxime Le Mignon, Nat Malainual, Emmanuel Nony, Alain Jacquet
BACKGROUND: Although the house dust mite species Blomia tropicalis is a leading cause of allergic diseases in tropical and subtropical regions, the identification and characterization of the allergenic proteins remains incomplete. OBJECTIVE: We aimed to characterize a recombinant form of Blo t 7 (rBlo t 7) in terms of IgE reactivity, lipid binding activity and ability to stimulate innate immunity. METHODS: The mature Blo t 7 cDNA was cloned by PCR methods for the expression of a secreted form of the allergen in P...
January 22, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29356182/retinoic-acid-signalling-is-a-candidate-regulator-of-the-expression-of-pituitary-specific-transcription-factor-prop1-in-the-developing-rodent-pituitary
#17
Saishu Yoshida, Ken Fujiwara, Hiroto Nishihara, Takako Kato, Takashi Yashiro, Yukio Kato
Development of the anterior pituitary proceeds via spatiotemporal patterning of transcription factors and signalling molecules. Among them, retinoic acid (RA) functions as an important signalling molecule for vertebrate organogenesis in many tissues. However, little is known regarding target genes in the developing pituitary. The present study aimed to clarify the relationship between endogenous RA signalling and mRNA expression of the pituitary-specific transcription factor Prop1 in the pituitary primordium of Rathke's pouch...
January 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29356170/t-cell-papulosis-associated-with-b-cell-malignancy-a-distinctive-clinicopathologic-entity
#18
L V Visseaux, A D Durlach, S B Barete, M B B Beylot-Barry, N B Bonnet, A F C Chassine, N F Franck, G H Herve, C L Leclec'h, L M Machet, S I O Ingen-Housz-Oro, T P Petrella, B V Vergier, N O Ortonne, F G Grange
BACKGROUND: A distinctive eruption referred to as "insect bite-like reaction", or "eosinophilic dermatosis of hematologic malignancy" has been described during the course of hematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear. OBJECTIVES: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. METHODS: In this multicenter retrospective study of the French Study Group on Cutaneous Lymphomas, 37 patients with a BCM and a cutaneous eruption consisting in chronic and/or recurrent papules, papulo-vesicles and/or nodules were included...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29356167/targeting-of-mir-31-96-182-to-the-numb-gene-during-head-and-neck-oncogenesis
#19
Chung-Hsien Chou, Hsi-Feng Tu, Shou-Yen Kao, Chun-Yu Fan Chiang, Chung-Ji Liu, Kuo-Wei Chang, Shu-Chun Lin
BACKGROUND: MicroRNAs (miRNAs) play crucial roles in head and neck squamous cell carcinoma (HNSCC). This study investigates whether miR-31, miR-96, and miR-182 are involved in targeting Numb during HNSCC. METHODS: The expression of miR-31/96/182 in tumor tissues was analyzed. Reporter assay, knockdown, expression, and oncogenic analysis were carried out in cell lines. RESULTS: Upregulation of miR-31/96/182 was detected in tumor tissues. In addition, advanced tumors showed higher expression levels of these miRNAs...
January 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29356162/comparison-of-three-gamma-oscillations-in-the-mouse-entorhinal-hippocampal-system
#20
James L Butler, Y Audrey Hay, Ole Paulsen
The entorhinal-hippocampal system is an important circuit in the brain, essential for certain cognitive tasks such as memory and navigation. Different gamma oscillations occur in this circuit, with the medial entorhinal cortex (mEC), CA3, and CA1 all generating gamma oscillations with different properties. These three gamma oscillations converge within CA1, where much work has gone into trying to isolate them from each other. Here we compared the gamma generators in the mEC, CA3, and CA1 using optogenetically-induced theta-gamma oscillations...
January 22, 2018: European Journal of Neuroscience
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