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Judith Roca, Silvia Gros, Olga Canet
INTRODUCTION: The bachelor thesis, a final year subject to obtain a nursing degree, presents an ideal opportunity for the development and assessment of professional competencies. Thus, it is necessary to specify that the structure of the bachelor thesis works as an element of review and reflection from both a pedagogical and professional perspective. OBJECTIVE: To analyse the main elements of the bachelor thesis in the nursing degree 2015-16 in Spain. METHODOLOGY: A transversal descriptive study was conducted using a quantitative documentary analysis via study guides or grade reports...
June 11, 2018: Nurse Education Today
Chiara Cavalli, Vincenzo Tarzia, Massimo Marini, Dario Gregori, Silvia Casella, Tomaso Bottio, Giuseppe Toscano, Angela Pompea Fraiese, Antonio Gambino, Biancarosa Volpe, Gino Gerosa
BACKGROUND: the aim of the current study was to evaluate and compare the quality of life (QOL) and psychological status of adult patients who underwent heart transplant (HTx) at pediatric or adult ages. METHODS: The population consisted of two groups: patients who received HTx after 18 years-old, pediatrics who received HTx between the age of 1 and 18 years. At the time of the study all patients were over 18 years old. QOL data were collected from patients using 36-item Short Form Health Survey (SF-36) and psychological-distress by the Symptom checklist 90-revised questionnaire (SCL-90-R)...
June 23, 2018: Clinical Transplantation
Sara L Buckingham, Anne E Brodsky, Alessia Rochira, Angela Fedi, Terri Mannarini, Lindsay Emery, Surbhi Godsay, Anna Miglietta, Silvia Gattino
Community psychology is central to understanding how immigrants and more established residents of their new settings join together to develop a shared sense of community and membership. In our present study, we explored how newer (i.e., first- and second-generation immigrants) and more established community members form multiple positive psychological sense of community (PSOC) with one another. We conducted a multinational, qualitative study of PSOC through interviews with 201 first- and second-generation immigrants and third generation or more "receiving community members" in three contexts (Baltimore-Washington corridor of the U...
June 22, 2018: American Journal of Community Psychology
Silvia Gramolelli, Jianpin Cheng, Ines Martinez-Corral, Markus Vähä-Koskela, Endrit Elbasani, Elisa Kaivanto, Ville Rantanen, Krista Tuohinto, Sampsa Hautaniemi, Mark Bower, Caj Haglund, Kari Alitalo, Taija Mäkinen, Tatiana V Petrova, Kaisa Lehti, Päivi M Ojala
The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles. Here, we show that PROX1 suppresses the transcription of MMP14, a metalloprotease involved in angiogenesis and cancer invasion, by binding and suppressing the activity of MMP14 promoter. Prox1 deletion in murine dermal lymphatic vessels in vivo and in human LECs increased MMP14 expression. In a hepatocellular carcinoma cell line expressing high endogenous levels of PROX1, its silencing increased both MMP14 expression and MMP14-dependent invasion in 3D...
June 22, 2018: Scientific Reports
Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci
In the version of this article originally published, the amino acid sequence for Tα1 described in the Online Methods is incorrect. The sequence is described as "Ac-SDAAVDTSSEITTJDLKEKKEVVEEAEN-OH". It should be "Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH". The error has been corrected in the HTML and PDF versions of this article.
June 22, 2018: Nature Medicine
Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci
In the version of this article originally published, some labels in Fig. 1f are incorrect. The "β-actin" labels on the second and fourth rows of blots should instead be "β-tubulin". The error has been corrected in the HTML and PDF versions of this article.
June 22, 2018: Nature Medicine
Špela Konjar, Ulrika C Frising, Cristina Ferreira, Reinhard Hinterleitner, Toufic Mayassi, Qifeng Zhang, Birte Blankenhaus, Nejc Haberman, Yunhua Loo, Joana Guedes, Marta Baptista, Silvia Innocentin, Joerg Stange, Douglas Strathdee, Bana Jabri, Marc Veldhoen
Epithelial-resident T lymphocytes, such as intraepithelial lymphocytes (IELs) located at the intestinal barrier, can offer swift protection against invading pathogens. Lymphocyte activation is strictly regulated because of its potential harmful nature and metabolic cost, and most lymphocytes are maintained in a quiescent state. However, IELs are kept in a heightened state of activation resembling effector T cells but without cytokine production or clonal proliferation. We show that this controlled activation state correlates with alterations in the IEL mitochondrial membrane, especially the cardiolipin composition...
June 22, 2018: Science Immunology
Jessica de Almeida Roger, Massimiliano Magro, Silvia Spagnolo, Emanuela Bonaiuto, Davide Baratella, Luca Fasolato, Fabio Vianello
An innovative core-shell nanocarrier, combining the magnetism of surface active maghemite nanoparticles (SAMNs, the core) and tannic acid (TA, the shell) was self-assembled by simple incubation in water. Due to the drastic reorganization of SAMN surface, the prepared magnetic nanocarrier (SAMN@TA) resulted as one of the most robust nanomaterial bearing TA to date. Nevertheless, the ferric tannates network, constituting the SAMN@TA shell, and the free tannic acid display comparable chemical behavior. The antimicrobial properties of SAMN@TA were tested on Listeria monocytogenes in comparison with free TA, showing similar bacteriostatic effects at relatively low concentrations...
November 30, 2018: Food Chemistry
Pedro Costa Del Amo, Julio Lahoz Beneytez, Lies Boelen, Raya Ahmed, Kelly L Miners, Yan Zhang, Laureline Roger, Rhiannon E Jones, Silvia A Fuertes Marraco, Daniel E Speiser, Duncan M Baird, David A Price, Kristin Ladell, Derek Macallan, Becca Asquith
Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised that a self-renewing population of T cells, named stem cell-like memory T (TSCM) cells, are responsible for maintaining memory. However, it is not clear if the dynamics of TSCM cells in vivo are compatible with this hypothesis. To address this issue, we investigated the dynamics of TSCM cells under physiological conditions in humans in vivo using a multidisciplinary approach that combines mathematical modelling, stable isotope labelling, telomere length analysis, and cross-sectional data from vaccine recipients...
June 22, 2018: PLoS Biology
Annette Pisanski, Silvia Pagliardini
Breathing at rest is typically characterized by three phases: active inspiration, post-inspiration (or stage 1 expiration), and passive expiration (or stage 2 expiration). Breathing during periods of increased respiratory demand, on the other hand, engages active expiration through recruitment of abdominal muscles in order to increase ventilation. It is currently hypothesized that different phases of the respiratory rhythm are driven by three coupled oscillators: the preBötzinger Complex, driving inspiration, the parafacial respiratory group (pFRG), driving active expiration and the post-inspiratory Complex, driving post-inspiration...
June 19, 2018: Respiratory Physiology & Neurobiology
Nelma Cristina Silva Pacheco, Ana Paula Carli de Almeida, Kariny Cássia de Siqueira, Faena Moura de Lima, Silvia Regina de Lima Reis, Marcia Queiroz Latorraca, Luiz Fabrizio Stoppiglia
Nutritional recovery of early malnutrition with soybean diet reduces liver glycogen stores in the fed state and produces liver insulin resistance. We investigated whether nutritional recovery on a soybean flour diet alters hepatic gluconeogenesis in the adult offspring of rats deprived of protein during pregnancy and lactation. Male rats from mothers that were fed either 17% (C) or 6% (L) protein during pregnancy and lactation were maintained on a 17% casein (CC, n=16 and LC, n=17), 17% soybean flour (CS, n=10 and LS, n=10) or 6% casein (LL, n=10) diet after weaning...
June 22, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Katarzyna Piwocka, Tomasz Skorski
No abstract text is available yet for this article.
June 22, 2018: Leukemia & Lymphoma
Vicente Marchan, Ana Zamora, Albert Gandioso, Anna Massaguer, Silvia Buenestado, Carme Calvis, Jose Luis Hernández, Francesc Mitjans, Venancio Rodríguez, Jose Ruiz
A novel conjugate between a cyclometalated platinum(II) complex with dual anti-angiogenic and antitumor activity and a cyclic peptide containing the RGD sequence (-Arg-Gly-Asp-) has been synthesized by combining solid- and solution-phase methodologies. Although peptide conjugation rendered a non-cytotoxic compound in all tested tumor cell lines (+/- αVβ3 and αVβ5 integrin receptors), the anti-angiogenic activity of the Pt-c(RGDfK) conjugate in HUVEC cells at sub-cytotoxic concentrations opens the way to the design of a novel class of angiogenesis inhibitors through conjugation of metallodrugs with high anti-angiogenic activity to cyclic RGD-containing peptides or peptidomimetic analogues...
June 22, 2018: ChemMedChem
Lucía Lindow-López, Guadalupe Galíndez, Silvia Sühring, Valeria Pastrana-Ignes, Pablo Gorostiague, Angela Gutiérrez, Pablo Ortega-Baes
There is controversy over whether cactus species form soil seed banks. Although it is commonly assumed that cacti do not form seed banks, very few studies have evaluated them. In this work, we analyzed whether cactus species form soil seed banks, studying seed distribution, seed density and seed longevity in the Southern Central Andes. Soil samples were collected in two microhabitats (under nurse plants and in bare areas) at 12 selected sites. We determined seed presence-absence, density and distribution for 32 native cactus species...
June 22, 2018: Plant Biology
Rafael E Sanchez-Pupo, Danielle Johnston, Silvia Penuela
Pannexins (Panx1, 2, 3) are channel-forming glycoproteins expressed in mammalian tissues. We previously reported that N-glycosylation acts as a regulator of the localization and intermixing of Panx1 and Panx3, but its effects on Panx2 are currently unknown. Panx1 and Panx2 intermixing can regulate channel properties, and both pannexins have been implicated in neuronal cell death after ischemia. Our objectives were to validate the predicted N-glycosylation site of Panx2 and to study the effects of Panx2 glycosylation on localization and its capacity to interact with Panx1...
June 22, 2018: International Journal of Molecular Sciences
Silvia Scabini, Mattia Trunfio, Veronica Pirriatore, Daniele Imperiale, Sabrina Audagnotto, Roberto Bertucci, Valeria Ghisetti, Giacoma Cinnirella, Angelina Cistaro, Mariaelena Perna, Andrea Calcagno, Giovanni Di Perri
A case of progressive multifocal leukoencephalopathy (PML) is described in an HIV-negative patient with mixed connective-tissue disease (MCTD) on a minimally immunosuppressive treatment with hydroxychloroquine. The patient presented with right-sided weakness, episodes of disorientation and loss of short-term memory and of vision in her right eye. PML was diagnosed by JCV DNA on cerebrospinal fluid and radiological criteria. She was treated with off-label maraviroc and mirtazapine but died two months after hospital admission, despite a surprising decrease in the viral load of cerebrospinal fluid three weeks after starting therapy...
June 1, 2018: Le Infezioni in Medicina
Silvia Lai, Alessio Molfino, Oriano Mecarelli, Patrizia Pulitano, Santo Morabito, Valentina Pistolesi, Roberto Romanello, Alessia Zarabla, Alessandro Galani, Nicla Frassetti, Paola Aceto, Carlo Lai
Neurological, psychological, and cognitive disorders in chronic kidney disease may contribute to poor quality of life in these patients. The aim of this study was to assess the electroencephalographic, psychological, and cognitive changes before and after hemodialysis (HD) compared with healthy controls (HC). Sixteen HD patients and 15 HC were enrolled. Electroencephalogram (EEG), Minnesota multiphasic personality inventory (MMPI-2) Satisfaction profile (SAT-P), and Neuropsychological test Global z-scores (NPZ5) were performed before (T0) and after (T1) HD treatment and in HC...
June 22, 2018: Therapeutic Apheresis and Dialysis
Iveta Oravcova, Eva Mikuskova, Michaela Leitnerova, Jan Gyarfas, Andrea Mlcakova, Peter Szepe, Lukas Plank, Ludmila Demitrovicova, Vanda Mikudova, Silvia Cingelova, Michal Mego, Lubos Drgona
Myeloid sarcoma is a rare presentation of acute leukemia as a solid tumor at various extramedullary sites. It may present concurrently, before or after the onset of systemic bone marrow leukemia. Unusual clinical localization may lead to misdiagnosis, or delayed diagnosis and treatment. We describe the first case, to our knowledge, of de novo myeloid sarcoma of the breast confirmed as acute promyelocytic leukemia. Immunohistochemical analysis, flow cytometry, fluorescent in situ hybridization analysis and molecular analysis using RQ-PCR of tissue samples should be routine in determining the correct diagnosis in this setting...
June 21, 2018: International Journal of Hematology
Thomas Vogel, Rebekka Maria Wrobel, Oliver Graupner, Silvia Lobmaier, Hubertus Feussner, Bettina Kuschel
INTRODUCTION: Little is known concerning the interaction of achalasia and pregnancy and about an optimal time and type for treatment. Achalatic women of our collective of patients with at least one pregnancy in their history resulting in confinement or miscarriage were invited for a structured interview. MATERIALS AND METHODS: 43 of 109 female patients were included. Questionnaire contained questions on symptoms, type of symptoms, whether patients could link a specific event with outbreak of disease...
June 21, 2018: Archives of Gynecology and Obstetrics
Melisa C Monteleone, María Eugenia Pallarés, Silvia C Billi, Marta C Antonelli, Marcela A Brocco
Prenatal stress (PS) induces molecular changes that alter neural connectivity, increasing the risk for neuropsychiatric disorders. Here we analyzed -in the hippocampus of adult rats exposed to PS- the epigenetic signature mediating the PS-induced neuroplasticity changes. Furthermore, using cultured hippocampal neurons, we investigated the effects on neuroplasticity of an epigenetic modulator. PS induced significant modifications in the mRNA levels of stress-related transcription factor MEF2A, SUV39H1 histone methyltransferase, and TET1 hydroxylase, indicating that PS modifies gene expression through chromatin remodeling...
June 22, 2018: Journal of Molecular Neuroscience: MN
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