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https://www.readbyqxmd.com/read/29458213/selective-targeting-and-degradation-of-doxorubicin-loaded-folate-functionalized-dna-nanocages
#1
Sofia Raniolo, Giulia Vindigni, Alessio Ottaviani, Valeria Unida, Federico Iacovelli, Antonio Manetto, Mariangela Figini, Lorenzo Stella, Alessandro Desideri, Silvia Biocca
Selective targeting is a crucial property of nanocarriers used for drug delivery in cancer therapy. We generated biotinylated octahedral DNA nanocages functionalized with folic acid through bio-orthogonal conjugation chemistry. Molecular modelling indicated that a distance of about 2.5 nm between folic acid and DNA nanocage avoids steric hindrance with the folate receptor. HeLa cells, a folate receptor positive tumour cell line, internalize folate-DNA nanocages with efficiency greater than 40 times compared to cells not expressing the folate receptors...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29457996/the-tyg-index-cutoff-point-and-its-association-with-body-adiposity-and-lifestyle-in-children
#2
Sarah A Vieira Ribeiro, Poliana C A Fonseca, Cristiana S Andreoli, Andréia Q Ribeiro, Helen H M Hermsdorff, Patrícia F Pereira, Silvia E Priore, Sylvia C C Franceschini
OBJECTIVE: To investigate the factors associated with insulin resistance in children aged 4-7 years, and to identify the cutoff point of the triglyceride-glucose index for the prediction of IR in this population. METHODS: A cross-sectional study was conducted with 403 children from a retrospective cohort. Insulin resistance was also evaluated in a sub-sample using the HOMA index. Four indicators of body adiposity were assessed: body mass index, waist-to-height ratio, and the percentages of total and central body fat...
February 16, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29457796/h3b-8800-an-orally-available-small-molecule-splicing-modulator-induces-lethality-in-spliceosome-mutant-cancers
#3
Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg Keaney, Michael Thomas, Anant A Agrawal, Benjamin Caleb, Alfredo Csibi, Eckley Sean, Peter Fekkes, Craig Karr, Virginia Klimek, George Lai, Linda Lee, Pavan Kumar, Stanley Chun-Wei Lee, Xiang Liu, Crystal Mackenzie, Carol Meeske, Yoshiharu Mizui, Eric Padron, Eunice Park, Ermira Pazolli, Shouyong Peng, Sudeep Prajapati, Justin Taylor, Teng Teng, John Wang, Markus Warmuth, Huilan Yao, Lihua Yu, Ping Zhu, Omar Abdel-Wahab, Peter G Smith, Silvia Buonamici
Genomic analyses of cancer have identified recurrent point mutations in the RNA splicing factor-encoding genes SF3B1, U2AF1, and SRSF2 that confer an alteration of function. Cancer cells bearing these mutations are preferentially dependent on wild-type (WT) spliceosome function, but clinically relevant means to therapeutically target the spliceosome do not currently exist. Here we describe an orally available modulator of the SF3b complex, H3B-8800, which potently and preferentially kills spliceosome-mutant epithelial and hematologic tumor cells...
February 19, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29457659/improved-production-purification-and-characterization-of-biosurfactants-produced-by-serratia-marcescens-sm3-and-its-isogenic-smrg-5-strain
#4
Nashbly Sarela Rosas-Galván, Fernando Martínez-Morales, Silvia Marquina-Bahena, Raunel Tinoco-Valencia, Leobardo Serrano-Carreón, Brandt Bertrand, Renato León-Rodríguez, Josefina Guzmán-Aparicio, Laura Alvaréz-Berber, María Del Refugio Trejo-Hernández
In this study the biosurfactant (Bs) production of two Serratia marcescens strains (SM3 and its isogenic SMRG-5 strain) was improved and the tenso-active agents were purified and characterized. A 23 factorial design was used to evaluate the effect of nitrogen and carbon sources on the surface tension (ST) reduction and emulsion index (EI24 ) of the produced Bs. Optimum Bs production by SM3 was achieved at high concentrations of carbon and nitrogen, reducing ST to 26.5 ± 0.28 dynes/cm, with an EI24 of 79.9 ± 0...
February 19, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29457449/catalytically-active-single-chain-polymeric-nanoparticles-exploring-their-functions-in-complex-biological-media
#5
Yiliu Liu, Silvia Pujals, Patrick J M Stals, Thomas Pauloehrl, Stanislav I Presolski, E W Meijer, Lorenzo Albertazzi, Anja R A Palmans
Dynamic single-chain polymeric nanoparticles (SCPNs) are intriguing, bioinspired architectures that result from the collapse or folding of an individual polymer chain into a nanometer-sized particle. Here we present a detailed biophysical study on the behavior of dynamic SCPNs in living cells and an evaluation of their catalytic functionality in such a complex medium. We first developed a number of delivery strategies that allowed the selective localization of SCPNs in different cellular compartments. Live/dead tests showed that the SCPNs were not toxic to cells while spectral imaging revealed that SCPNs provide a structural shielding and reduced the influence from the outer biological media...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29456932/neither-hereditary-periodic-fever-nor-periodic-fever-aphthae-pharingitis-adenitis-undifferentiated-periodic-fever-in-a-tertiary-pediatric-center
#6
Silvia De Pauli, Sara Lega, Serena Pastore, Domenico Leonardo Grasso, Anna Monica Rosaria Bianco, Giovanni Maria Severini, Alberto Tommasini, Andrea Taddio
AIM: To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever (UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up. METHODS: Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected...
February 8, 2018: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/29456551/genetic-diversity-of-the-endangered-neotropical-cichlid-fish-gymnogeophagus-setequedas-in-brazil
#7
Lenice Souza-Shibatta, Thais Kotelok-Diniz, Dhiego G Ferreira, Oscar A Shibatta, Silvia H Sofia, Lucileine de Assumpção, Suelen F R Pini, Sergio Makrakis, Maristela C Makrakis
Gymnogeophagus setequedas is a rare and rheophilic species of tribe Geophagini, considered endangered in Brazilian red lists. Its previously known geographical distribution range was the Paraná River basin, in Paraguay, and a tributary of the Itaipu Reservoir in Brazil. Since its description no specimens have been collected in the original known distribution area. However, recent records of G. setequedas in the lower Iguaçu River, in a region considered highly endemic for the ichthyofauna, extended the known geographical distribution and may represent one of the last remnants of the species...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29456184/quantified-f-actin-morphology-is-predictive-of-phagocytic-capacity-of-stem-cell-derived-retinal-pigment-epithelium
#8
Claudia Müller, Carol Charniga, Sally Temple, Silvia C Finnemann
With stem cell-derived retinal pigment epithelial (RPE) replacement therapies in clinical testing, establishing potency of RPE prior to transplantation is imperative. Phagocytosis of photoreceptor outer segment fragments (POS) is a key indicator of RPE functionality. Comparing RPE derived from different donor human adult RPE stem cell lines, we found that cells were either high-phagocytic or low-phagocytic despite sharing phagocytic receptors and ligands, junctional ZO-1, and lack of epithelial-mesenchymal transition...
February 9, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29456145/the-interrelationships-of-land-plants-and-the-nature-of-the-ancestral-embryophyte
#9
Mark N Puttick, Jennifer L Morris, Tom A Williams, Cymon J Cox, Dianne Edwards, Paul Kenrick, Silvia Pressel, Charles H Wellman, Harald Schneider, Davide Pisani, Philip C J Donoghue
The evolutionary emergence of land plant body plans transformed the planet. However, our understanding of this formative episode is mired in the uncertainty associated with the phylogenetic relationships among bryophytes (hornworts, liverworts, and mosses) and tracheophytes (vascular plants). Here we attempt to clarify this problem by analyzing a large transcriptomic dataset with models that allow for compositional heterogeneity between sites. Zygnematophyceae is resolved as sister to land plants, but we obtain several distinct relationships between bryophytes and tracheophytes...
February 12, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29456139/selective-attention-gates-the-interactive-crossmodal-coupling-between-perceptual-systems
#10
Silvia Convento, Md Shoaibur Rahman, Jeffrey M Yau
Sensory cortical systems often activate in parallel, even when stimulation is experienced through a single sensory modality [1-3]. Co-activations may reflect the interactive coupling between information-linked cortical systems or merely parallel but independent sensory processing. We report causal evidence consistent with the hypothesis that human somatosensory cortex (S1), which co-activates with auditory cortex during the processing of vibrations and textures [4-9], interactively couples to cortical systems that support auditory perception...
February 1, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29456044/mesoporous-silica-nanoparticles-functionalized-with-hyaluronic-acid-effect-of-the-biopolymer-chain-length-on-cell-internalization
#11
Valentina Nairi, Silvia Magnolia, Marco Piludu, Mariella Nieddu, Cristian Antonio Caria, Valeria Sogos, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2 ) and then with hyaluronic acid, a biocompatible biopolymer which can be recognized by CD44 receptors in tumor cells, to obtain a targeting drug delivery system. To this purpose, three hyaluronic acid samples differing for the molecular weight, namely HAS (8-15 kDa), HAM (30-50 kDa) and HAL (90-130 kDa), were used. The MSN-HAS , MSN-HAM , and MSN-HAL materials were characterized through zeta potential and dynamic light scattering measurements at pH = 7...
February 12, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29455924/gec-estro-acrop-recommendations-in-skin-brachytherapy
#12
Jose L Guinot, Agata Rembielak, Jose Perez-Calatayud, Silvia Rodríguez-Villalba, Janusz Skowronek, Luca Tagliaferri, Benjamin Guix, Victor Gonzalez-Perez, Vincenzo Valentini, György Kovacs
PURPOSE: The aim of this publication is to compile available literature data and expert experience regarding skin brachytherapy (BT) in order to produce general recommendations on behalf of the GEC-ESTRO Group. METHODS: We have done an exhaustive review of published articles to look for general recommendations. RESULTS: Randomized controlled trials, systemic reviews and meta-analysis are lacking in literature and there is wide variety of prescription techniques successfully used across the radiotherapy centers...
February 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29455684/optimizing-usability-of-an-economic-decision-support-tool-prototype-of-the-equipt-tool
#13
Kei Long Cheung, Mickaël Hiligsmann, Maximilian Präger, Teresa Jones, Judit Józwiak-Hagymásy, Celia Muñoz, Adam Lester-George, Subhash Pokhrel, Ángel López-Nicolás, Marta Trapero-Bertran, Silvia M A A Evers, Hein de Vries
OBJECTIVES: Economic decision-support tools can provide valuable information for tobacco control stakeholders, but their usability may impact the adoption of such tools. This study aims to illustrate a mixed-method usability evaluation of an economic decision-support tool for tobacco control, using the EQUIPT ROI tool prototype as a case study. METHODS: A cross-sectional mixed methods design was used, including a heuristic evaluation, a thinking aloud approach, and a questionnaire testing and exploring the usability of the Return of Investment tool...
February 19, 2018: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29455430/existential-meaning-of-patients-with-chronic-facial-pain
#14
Silvia Regina Dowgan Tesseroli de Siqueira
Coping strategies are necessary to deal with pain, one of the most disabling conditions. Treatments are often refractory, and the elaboration of existential meaning is necessary to live with residual pain. The objective of this study was to discuss the relevance of the meaning of life in coping with refractory chronic neuropathic facial pain according to singular cases. Each patient is unique and needs a singular approach to understand and treat the pain phenomenon. Self-transcendence, existential issues and philosophical values are central concepts to assess chronic conditions and should be highlighted in medical practice these days...
February 17, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29455416/pharmacological-inhibition-of-the-skeletal-ikk%C3%AE-reduces-breast-cancer-induced-osteolysis
#15
Silvia Marino, Ryan T Bishop, Patrick Mollat, Aymen I Idris
IKKβ has previously been implicated in breast cancer bone metastasis and bone remodelling. However, the contribution of IKKβ expressed by bone cells of the tumour microenvironment to breast cancer-induced osteolysis has yet to be investigated. Here, we studied the effects of the verified selective IKKβ inhibitors IKKβIII or IKKβV on osteoclast formation and osteoblast differentiation in vitro and in vivo, human and mouse breast cancer cells' support for osteoclast formation and signalling in vitro and osteolysis ex vivo and in immunocompetent mice after supracalvarial injection of human MDA-MB-231 conditioned medium or intra-cardiac injection of syngeneic 4T1 breast cancer cells...
February 17, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29455020/bayesian-networks-of-age-estimation-and-classification-based-on-dental-evidence-a-study-on-the-third-molar-mineralization
#16
Emanuele Sironi, Vilma Pinchi, Francesco Pradella, Martina Focardi, Silvia Bozza, Franco Taroni
Not only does the Bayesian approach offer a rational and logical environment for evidence evaluation in a forensic framework, but it also allows scientists to coherently deal with uncertainty related to a collection of multiple items of evidence, due to its flexible nature. Such flexibility might come at the expense of elevated computational complexity, which can be handled by using specific probabilistic graphical tools, namely Bayesian networks. In the current work, such probabilistic tools are used for evaluating dental evidence related to the development of third molars...
February 9, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29454927/syndemics-among-individuals-enrolled-in-the-prep-brasil-study
#17
Raquel B De Boni, Iona K Machado, Mauricio T L De Vasconcellos, Brenda Hoagland, Esper G Kallas, José Valdez Madruga, Nilo M Fernandes, Natalia B Cerqueira, Ronaldo I Moreira, Silvia P Goulart, Valdilea G Veloso, Beatriz Grinsztejn, Paula M Luz
BACKGROUND: Concurrent psychosocial problems may synergistically increase the risk of HIV infection (syndemics), representing a challenge for prevention. We aimed to evaluate the prevalence and associated factors of syndemics among men who have sex with men (MSM) and transgender women (TGW) enrolled in the Brazilian pre-exposure prophylaxis demonstration study (PrEP Brasil Study). METHODS: Secondary cross-sectional analysis of the PrEP Brasil Study was performed...
February 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29454817/investigating-the-feasibility-of-a-reuse-scenario-for-textile-fibres-recovered-from-end-of-life-tyres
#18
Daniele Landi, Silvia Gigli, Michele Germani, Marco Marconi
The management of end-of-life tyres (ELTs) is regulated by several national and international legislations aiming to promote the recovery of materials and energy from this waste. The three main materials used in tyres are considered: rubber (main product), which is currently reused in other closed-loop applications; steel, which is used for the production of virgin materials; and textile fibres (approximately 10% by weight of ELTs), which are mainly incinerated for energy recovery (open-loop scenario). This study aims to propose and validate a new closed-loop scenario for textile fibres based on material reuse for bituminous conglomerates...
February 14, 2018: Waste Management
https://www.readbyqxmd.com/read/29454346/agrobacterium-mediated-and-electroporation-mediated-transformation-of-chlamydomonas-reinhardtii-a-comparative-study
#19
Paola Mini, Olivia Costantina Demurtas, Silvia Valentini, Patrizia Pallara, Giuseppe Aprea, Paola Ferrante, Giovanni Giuliano
BACKGROUND: Chlamydomonas reinhardtii is an unicellular green alga used for functional genomics studies and heterologous protein expression. A major hindrance in these studies is the low level and instability of expression of nuclear transgenes, due to their rearrangement and/or silencing over time. RESULTS: We constructed dedicated vectors for Agrobacterium-mediated transformation carrying, within the T-DNA borders, the Paromomycin (Paro) selectable marker and an expression cassette containing the Luciferase (Luc) reporter gene...
February 17, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29454149/study-of-manganese-binding-to-the-ferroxidase-centre-of-human-h-type-ferritin
#20
Matteo Ardini, Barry D Howes, Annarita Fiorillo, Elisabetta Falvo, Silvia Sottini, Donella Rovai, Marco Lantieri, Andrea Ilari, Dante Gatteschi, Gabriele Spina, Emilia Chiancone, Simonetta Stefanini, Maria Fittipaldi
Ferritins are ubiquitous and conserved proteins endowed with enzymatic ferroxidase activity, that oxidize Fe(II) ions at the dimetal ferroxidase centre to form a mineralized Fe(III) oxide core deposited within the apo-protein shell. Herein, the in vitro formation of a heterodimetal cofactor constituted by Fe and Mn ions has been investigated in human H ferritin (hHFt). Namely, Mn and Fe binding at the hHFt ferroxidase centre and its effects on Fe(II) oxidation have been investigated by UV-Vis ferroxidation kinetics, fluorimetric titrations, multifrequency EPR, and preliminary Mössbauer spectroscopy...
February 9, 2018: Journal of Inorganic Biochemistry
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