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https://www.readbyqxmd.com/read/28932365/causal-role-of-infectious-agents-in-cancer-an-overview
#1
REVIEW
Jila Masrour-Roudsari, Soheil Ebrahimpour
Cancer is a complex group of diseases with multiple eventual causes. The underlying causes are not fully known. Thus, learning more about the known causes of cancer is an important issue. Moreover, among these factors, infection and its association to cancers is controversial. Although, it seems that the genome instability of the cells can initiate cancer development. The purpose of this review was to present the role of infection in the development of cancer. Infectious agents, such as hepatitis B (HBV) and C viruses (HCV), Epstein-Barr virus (EBV), human papillomavirus (HPV), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori (H...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28931221/modeling-of-us-human-papillomavirus-hpv-seroprevalence-by-age-and-sexual-behavior-indicates-an-increasing-trend-of-hpv-infection-following-the-sexual-revolution
#2
Marc D Ryser, Anne Rositch, Patti E Gravitt
Background: The United States has experienced an increase in the incidence of human papillomavirus (HPV)-related cancers that are not screen-detectable. It has been hypothesized, but not directly demonstrated, that this is due to increasing HPV prevalence in the unvaccinated population. Methods: Female self-reported numbers of lifetime sex partners and HPV serology from the National Health and Nutrition Examination Survey (NHANES) were used to develop mathematical models of sexual partner acquisition and antibody dynamics...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28927463/towards-precision-medicine-discovering-novel-gynecological-cancer-biomarkers-and-pathways-using-linked-data
#3
Alokkumar Jha, Yasar Khan, Muntazir Mehdi, Md Rezaul Karim, Qaiser Mehmood, Achille Zappa, Dietrich Rebholz-Schuhmann, Ratnesh Sahay
BACKGROUND: Next Generation Sequencing (NGS) is playing a key role in therapeutic decision making for the cancer prognosis and treatment. The NGS technologies are producing a massive amount of sequencing datasets. Often, these datasets are published from the isolated and different sequencing facilities. Consequently, the process of sharing and aggregating multisite sequencing datasets are thwarted by issues such as the need to discover relevant data from different sources, built scalable repositories, the automation of data linkage, the volume of the data, efficient querying mechanism, and information rich intuitive visualisation...
September 19, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28921916/inversed-expression-patterns-of-s100a4-and-e-cadherin-in-cervical-cancers-implication-in-epithelial-mesenchymal-transition
#4
Ming Liu, Jia Liu, Bin Yang, Xue Gao, Ling-Lu Gao, Qing-You Kong, Peng Zhang, Hong Li
Cervical cancer/CC is the third commonest female malignancy worldwide. The aggressive growth and distal metastases are the leading causes of CC mortality, which is largely due to epithelial-mesenchymal transition/EMT. Fibroblast specific protein S100A4 promotes cancer metastasis and epithelial type cadherin/E-cadherin play pivotal roles in cell-cell and cell-extracellular matrix interaction. Therefore, the expression patterns of S100A4 and E-cadherin reflect statuses of EMT of carcinoma cells. However, S100A4 expression and its relevance with E-cadherin and HPV16 infection in cervical cancers remain unknown...
September 16, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28912897/genomic-analysis-of-tumor-microenvironment-immune-types-across-14-solid-cancer-types-immunotherapeutic-implications
#5
Yu-Pei Chen, Yu Zhang, Jia-Wei Lv, Ying-Qin Li, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Yan-Ping Mao, Jing-Ping Yun, Na Liu, Jun Ma
We performed a comprehensive immuno-genomic analysis of tumor microenvironment immune types (TMITs), which is classified into four groups based on PD-L1+CD8A or PD-L1+cytolytic activity (CYT) expression, across a broad spectrum of solid tumors in order to help identify patients who will benefit from anti- PD-1/PD-L1 therapy. The mRNA sequencing data from The Cancer Genome Atlas (TCGA) of 14 solid cancer types representing 6,685 tumor samples was analyzed. TMIT was classified only for those tumor types that both PD-L1 and CD8A/CYT could prefict mutation and/or neoantigen number...
2017: Theranostics
https://www.readbyqxmd.com/read/28911147/kif5b-ret-rearrangement-in-a-carcinoma-of-the-thyroid-gland-a-case-report-of-a-fatal-disease
#6
David Viola, Carlotta Giani, Salvatore Mazzeo, Clara Ugolini, Raffaele Ciampi, Eleonora Molinaro, Laura Agate, Nicla Borrelli, Antonio Chella, Gabriella Fontanini, Fulvio Basolo, Rossella Elisei
Background: The diffuse sclerosing variant of papillary thyroid cancer (DSV-PTC) is a rare variant of papillary thyroid cancer (PTC) with different clinicopathological features compared with conventional PTC. Case: An advanced DSV-PTC was diagnosed in a 39-year-old man. The radioiodine posttherapeutic whole-body-scan showed only an uptake in the central neck, whereas the computerized tomography showed multiple latero-cervical and mediastinum lymph node metastases, a single and spiculated lung lesion and multiple bilateral cerebellum metastases...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28905618/functionalization-of-reduced-graphene-oxide-via-thiol-maleimide-click-chemistry-facile-fabrication-of-targeted-drug-delivery-vehicles
#7
Yavuz Oz, Alexandre Barras, Rana Sanyal, Rabah Boukherroub, Sabine Szunerits, Amitav Sanyal
Materials based on reduced graphene oxide (rGO) have shown to be amenable to noncovalent functionalization through hydrophobic interactions. The scaffold, however, does not provide sufficient covalent linkage given the low number of reactive carboxyl and alcohol groups typically available on the rGO. The integration of clickable groups, particularly the ones that can undergo efficient conjugation without any metal catalyst, would allow facile functionalization of these materials. This study reports on the noncovalent association of a maleimide-containing catechol (dopa-MAL) surface anchor onto the rGO...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28893569/fatty-acid-binding-protein-4-promotes-epithelial-mesenchymal-transition-in-cervical-squamous-cell-carcinoma-through-akt-gsk3%C3%AE-snail-signaling-pathway
#8
Jiangbo Jin, Ziyu Zhang, Song Zhang, Xinyu Chen, Zhen Chen, Ping Hu, Jianbin Wang, Caifeng Xie
Fatty acid binding protein 4 (FABP4) is a member of the fatty acid binding protein family which involved in a variety of biological cellular processes, including tumorigenesis. However, the role of this key adipokine in cervical cancer is still unclear. In this study, we explored the function of FABP4 in cervical cancer and the underlying molecular mechanisms. FABP4 was specifically elevated in tissue samples from patients with cervical squamous cell carcinoma (CSCC) but not with cervical adenocarcinoma, and the level of FABP4 was correlated with E-cadherin and Vimentin expression...
September 8, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28886907/final-efficacy-immunogenicity-and-safety-analyses-of-a-nine-valent-human-papillomavirus-vaccine-in-women-aged-16-26-years-a-randomised-double-blind-trial
#9
Warner K Huh, Elmar A Joura, Anna R Giuliano, Ole-Erik Iversen, Rosires Pereira de Andrade, Kevin A Ault, Deborah Bartholomew, Ramon M Cestero, Edison N Fedrizzi, Angelica L Hirschberg, Marie-Hélène Mayrand, Angela Maria Ruiz-Sternberg, Jack T Stapleton, Dorothy J Wiley, Alex Ferenczy, Robert Kurman, Brigitte M Ronnett, Mark H Stoler, Jack Cuzick, Suzanne M Garland, Susanne K Kjaer, Oliver M Bautista, Richard Haupt, Erin Moeller, Michael Ritter, Christine C Roberts, Christine Shields, Alain Luxembourg
BACKGROUND: Primary analyses of a study in young women aged 16-26 years showed efficacy of the nine-valent human papillomavirus (9vHPV; HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-inferior HPV 6, 11, 16, and 18 antibody responses when compared with quadrivalent HPV (qHPV; HPV 6, 11, 16, and 18) vaccine. We aimed to report efficacy of the 9vHPV vaccine for up to 6 years following first administration and antibody responses over 5 years...
September 5, 2017: Lancet
https://www.readbyqxmd.com/read/28877521/case-report-pulmonary-tumor-thrombotic-microangiopathy-in-a-cervical-cancer-patient
#10
Naoya Tsujimoto, Ai Miyoshi, Mayuko Mimura, Toshio Naka, Masaru Yamasaki, Takeshi Yokoi
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive and often fatal pulmonary disease induced by tumor emboli within the small pulmonary arteries. PTTM presents clinically as progressive hypoxia and pulmonary hypertension. Most cases of PTTM are caused by an adenocarcinoma of the stomach. We present the first case report of PTTM caused by cervical squamous cell carcinoma. An 82-year-old woman presented with vaginal bleeding and exertional dyspnea. A cervical mass biopsy showed squamous cell carcinoma...
September 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28863067/cervical-carcinoma-with-divergent-neuroendocrine-and-gastrointestinal-differentiation
#11
Kavita R Varma, David J Dabbs
Neuroendocrine carcinomas of the uterine cervix are rare tumors with aggressive behavior. They comprise <4% of cervical carcinomas. They may coexist with both adenocarcinoma and squamous cell carcinoma of cervix. Signet ring carcinoma of cervix is a rarer entity and less than 20 cases have been described in the literature. We present a case of a 34-year-old female who presented with systemic thrombosis, splenic mass and a cervical mass which on biopsy showed divergent differentiation of primitive large cell neuroendocrine carcinoma with signet ring cells...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28859123/prognostic-significance-of-the-co-expression-of-egfr-and-her2-in-adenocarcinoma-of-the-uterine-cervix
#12
Asako Ueda, Akira Takasawa, Taishi Akimoto, Kumi Takasawa, Tomoyuki Aoyama, Yoshihiko Ino, Masanori Nojima, Yusuke Ono, Masaki Murata, Makoto Osanai, Tadashi Hasegawa, Tsuyoshi Saito, Norimasa Sawada
Prognostic factors and therapeutic targets are needed for the patients with cervical adenocarcinoma because they have a poor prognosis. Recently, co-expression of multiple receptor tyrosine kinases (RTKs) has been found to be associated with aggressive biological behavior and poor prognosis of several types of malignancy. To evaluate the significance of the expression of multiple RTKs in uterine cervical cancers, we examined the expression profile of RTKs (EGFR, HER2 and c-Met) and the correlation of their expression with clinicopathological features and prognosis of patients with cervical adenocarcinomas...
2017: PloS One
https://www.readbyqxmd.com/read/28851799/excisional-treatment-in-women-with-cervical-adenocarcinoma-in-situ-ais-a-prospective-randomised-controlled-non-inferiority-trial-to-compare-ais-persistence-recurrence-after-loop-electrosurgical-excision-procedure-with-cold-knife-cone-biopsy-protocol-for-a-pilot
#13
Paul A Cohen, Alison Brand, Peter Sykes, David C H Wrede, Orla McNally, Lois Eva, Archana Rao, Michael Campion, Martin Stockler, Aime Powell, Jim Codde, Max K Bulsara, Lyndal Anderson, Yee Leung, Louise Farrell, Pennie Stoyles
INTRODUCTION: Adenocarcinoma in situ (AIS) of the uterine cervix is the precursor to invasive endocervical adenocarcinoma. An excisional biopsy such as a cold knife cone biopsy (CKC) should be performed to exclude invasive adenocarcinoma. Loop electrosurgical excision procedure (LEEP) is an alternative modality to CKC but is controversial in AIS. There is a perception that there is a greater likelihood of incomplete excision of AIS with LEEP because the depth of excised tissue tends to be smaller and the tissue margins may show thermal artefact which can interfere with pathology assessment...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28846628/cytotoxicity-of-the-essential-oil-of-fennel-foeniculum-vulgare-from-tajikistan
#14
Farukh Sharopov, Abdujabbor Valiev, Prabodh Satyal, Isomiddin Gulmurodov, Salomudin Yusufi, William N Setzer, Michael Wink
The essential oil of fennel (Foeniculum vulgare) is rich in lipophilic secondary metabolites, which can easily cross cell membranes by free diffusion. Several constituents of the oil carry reactive carbonyl groups in their ring structures. Carbonyl groups can react with amino groups of amino acid residues in proteins or in nucleotides of DNA to form Schiff's bases. Fennel essential oil is rich in anise aldehyde, which should interfere with molecular targets in cells. The aim of the present study was to investigate the chemical composition of the essential oil of fennel growing in Tajikistan...
August 28, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28843763/metastatic-basal-cell-adenocarcinoma-of-submandibular-gland-to-the-spine-an-extremely-rare-condition-a-case-report
#15
Tinnakorn Pluemvitayaporn, Sombat Kunakornsawat, Chaiwat Piyaskulkaew, Pritsanai Pruttikul, Warongporn Pongpinyopap
Basal cell adenocarcinomas (BCACs) are rare malignant neoplasms of salivary glands, accounting for less than 1% of salivary gland tumors. Few cases of distant metastases have been reported. To our knowledge, metastases to the spine have not been previously reported in the literature. We presented an unusual case of a 50-year-old Thai male, who was diagnosed as basal cell adenocarcinoma of submandibular gland with pulmonary and cervical spine metastases with progressive myelopathy, treated with wide surgical resection of the soft tissue tumor and modified radical neck dissection, anterior cervical total corpectomy with fusion combined with posterior decompression and fusion of the cervical spine and surgical wound coverage by anterolateral thigh free tissue transfer, followed by adjuvant radiotherapy...
August 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28840394/lipophilic-gold-i-complexes-with-1-3-4-oxadiazol-2-thione-or-1-3-thiazolidine-2-thione-moieties-synthesis-and-their-cytotoxic-and-antimicrobial-activities
#16
Angelina Maria de Almeida, Bruno Assis de Oliveira, Pedro Pôssa de Castro, Camille Carvalho de Mendonça, Ricardo Andrade Furtado, Heloiza Nicolella Diniz, Vânia Lúcia da Silva, Cláudio Galuppo Diniz, Denise Crispim Tavares, Heveline Silva, Mauro Vieira de Almeida
Novel lipophilic gold(I) complexes containing 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione derivatives were synthesized and characterized by IR, high resolution mass spectrometry, and (1)H, (13)C (31)P NMR. The cytotoxicity of the compounds was evaluated considering cisplatin and/or auranofin as reference in different tumor cell lines: colon cancer (CT26WT), metastatic skin melanoma (B16F10), breast adenocarcinoma (MCF-7), cervical carcinoma (HeLa), glioblastoma (M059 J). Normal human lung fibroblasts (GM07492-A) and kidney normal cell (BHK-21) were also evaluated...
August 24, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28839333/endometriosis-with-an-aberrant-immunophenotype-challenging-differential-diagnosis-of-glandular-lesions-in-the-pelvic-lymph-nodes
#17
Dita Vlckova, Jiri Lenz, Radek Chvatal, Jan Tihon, Miroslav Kavka, Lucie Uncapher
CASE REPORT: We describe an unusual case of pelvic lymph node endometriosis with an aberrant immunophenotype mimicking metastasis of adenocarcinoma. A 37-year-old patient with a history of invasive cervical adenocarcinoma stage pT1a2 is presented. Due to insufficient loop electrosurgical excision procedure (LEEP) conization, total laparoscopic hysterectomy with pelvic lymphadenectomy was indicated. Intraoperatively, the diagnosis of deep infiltrating endometriosis of parametrial ligament and vesicouterine pouch, endometrioma of the left ovary and Allen Master's syndrome was suspected; the patient had no history or clinical symptoms of endometriosis...
August 24, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28832082/synchronous-cervical-minimal-deviation-adenocarcinoma-gastric-type-adenocarcinoma-and-lobular-endocervical-glandular-hyperplasia-along-with-stil-in-peutz-jeghers-syndrome-eliciting-oncogenesis-pathways
#18
Azfar Neyaz, Nuzhat Husain, Manish Deodhar, Rohini Khurana, Saumya Shukla, Aditi Arora
We describe an unusual case of a Peutz-Jeghers syndrome associated with a composite synchronous cervical neoplasia comprising precursor "lobular endocervical glandular hyperplasia (LEGH)", "minimal deviation adenocarcinoma (MDA)" and "gastric-type adenocarcinoma (GTA)" along with a serous tubal intraepithelial lesion (STIL) in the right fallopian tube. A 24-year-old woman presented with a white mucoid discharge and bleeding per vaginum for one year. Histopathological evaluation showed MDA & GTA in FIGO grade III with pelvic lymph node metastasis despite a deceptively bland tumour morphology and low Ki-67 index, indicating an aggressive tumour course and poor prognosis...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28832070/panel-of-villin-pro-ex-c-estrogen-receptor-and-progesterone-receptor-expressions-could-help-in-differentiation-between-endocervical-and-endometrioid-adenocarcinoma
#19
Mariem Elfeky, Ola Harb, Loay Gertallah
OBJECTIVE: Endocervical and endometrioid adenocarcinoma have marked overlapping features and the differentiation between them is important for their accurate management. Villin is an actin-binding protein which has an important role in the maintenance of microvilli in epithelial cells and epithelial cell-specific anti-apoptotic protein processes. Pro-Ex-C is a marker for higher-risk human papilloma virus (HPV) which targets the cell cycle proteins causing their overexpression. The aim of the study was to clarify the diagnostic and predictive role of villin, Pro-Ex-C, estrogen receptor (ER) and progesterone receptor (PR) expression in endocervical and endometrioid adenocarcinoma...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28821199/keratin-17-is-a-prognostic-biomarker-in-endocervical-glandular-neoplasia
#20
Daniel Mockler, Luisa F Escobar-Hoyos, Ali Akalin, Jamie Romeiser, A Laurie Shroyer, Kenneth R Shroyer
Objectives: Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). K17, however, has not been previously evaluated in endocervical glandular neoplasia. Based on the similar pathogenesis of squamous and glandular lesions of the cervix, we hypothesized that K17 overexpression could also be a diagnostic and/or prognostic biomarker for endocervical neoplasia...
September 1, 2017: American Journal of Clinical Pathology
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