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https://www.readbyqxmd.com/read/28342625/development-of-a-theory-guided-storytelling-narrative-intervention-to-improve-hpv-vaccination-behavior-save-our-daughters-from-cervical-cancer
#1
Haeok Lee, Minjin Kim, Jeroan Allison, Peter Kiang
No abstract text is available yet for this article.
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28340235/polymerase-chain-reaction-human-papillomavirus-hpv-detection-and-hpv-genotyping-in-invasive-cervical-cancers-with-prior-negative-hc2-test-results
#2
Xiang Tao, Baowen Zheng, Fufen Yin, Zhengyu Zeng, Zaibo Li, Christopher C Griffith, Bing Luo, Xiangdong Ding, Xianrong Zhou, Chengquan Zhao
Objectives: Recently, three large Chinese cohort studies showed that 7.5% to 15.5% of patients with cervical carcinoma had negative high-risk human papillomavirus (hrHPV) test results on prior cytology specimens. These studies raise the question as to whether these negative hrHPV results represent truly hrHPV-negative carcinomas or false-negative hrHPV test results due to limitations in the testing of cytology specimens. This is increasingly an important question with increasing push to use hrHPV testing alone to screen for cervical cancer...
March 15, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28339040/detection-assay-for-hpv16-and-hpv18-by-loop%C3%A2-mediated-isothermal-amplification-with-lateral-flow-dipstick-tests
#3
Ratchanida Kumvongpin, Patcharee Jearanaikoon, Chotchana Wilailuckana, Nattaya Sae-Ung, Prinya Prasongdee, Sakda Daduang, Metee Wongsena, Patcharee Boonsiri, Wansika Kiatpathomchai, Sukumarn Sanersak Swangvaree, Alisa Sandee, Jureerut Daduang
Cervical cancer is the third highest cause of death in developing countries and most commonly results from high‑risk human papillomavirus (HR‑HPV) infection. Among HR‑HPV genotypes, HPV16 and HPV18 are the most prevalent in cervical cancers. Therefore, the present study aimed to develop a detection assay for HPV16 and HPV18 infection using loop‑mediated isothermal amplification (LAMP) with lateral flow dipstick (LFD) tests. This assay is a simplified, user‑friendly method for the visual detection of HPV genotypes...
March 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338494/combined-knockdown-of-d-dopachrome-tautomerase-and-migration-inhibitory-factor-inhibits-the-proliferation-migration-and-invasion-in-human-cervical-cancer
#4
Qingying Wang, Yingze Wei, Jiawen Zhang
OBJECTIVE: D-dopachrome tautomerase (D-DT) is a homologue of macrophage migration inhibitory factor (MIF) with similar functions. However, the possible biological roles of D-DT in cervical cancer remain unknown so far. METHODS: D-dopachrome tautomerase was assessed by immunohistochemistry in 83 cervical cancer and 31 normal cervix tissues. The stable knockdown of D-DT and MIF by lentivirus-delivered short hairpin RNA was established, and tumor growth was examined in vitro and in vivo...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28337643/recombinant-heat-shock-protein-27-hsp27-hspb1-protects-against-cadmium-induced-oxidative-stress-and-toxicity-in-human-cervical-cancer-cells
#5
Daiana G Alvarez-Olmedo, Veronica S Biaggio, Geremy A Koumbadinga, Nidia N Gómez, Chunhua Shi, Daniel R Ciocca, Zarah Batulan, Mariel A Fanelli, Edward R O'Brien
Cadmium (Cd) is a carcinogen with several well-described toxicological effects in humans, but its molecular mechanisms are still not fully understood. Overexpression of heat shock protein 27 (HSP27/HSPB1)-a multifunctional protein chaperone-has been shown to protect cells from oxidative damage and apoptosis triggered by Cd exposure. The aims of this work were to investigate the potential use of extracellular recombinant HSP27 to prevent/counteract Cd-induced cellular toxicity and to evaluate if peroxynitrite was involved in the development of Cd-induced toxicity...
March 24, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28337594/diagnostic-accuracy-of-high-risk-hpv-dna-genotyping-for-primary-cervical-cancer-screening-and-triage-of-hpv-positive-women-compared-to-cytology-preliminary-results-of-the-pipavir-study
#6
Kimon Chatzistamatiou, Theodoros Moysiadis, Eleftherios Angelis, Andreas Kaufmann, Alkmini Skenderi, Pidder Jansen-Duerr, Irini Lekka, Vasilis Kilintzis, Stamatia Angelidou, Evangelia Katsiki, Ingke Hagemann, Athena Tsertanidou, Isabel Koch, Oliver Boecher, Erwin Soutschek, Nikolaos Maglaveras, Theodoros Agorastos
PURPOSE: The purpose of the presented PIPAVIR (persistent infections with human papillomaviruses; http://www.pipavir.com ) subanalysis is to assess the performance of high-risk (hr) HPV-DNA genotyping as a method of primary cervical cancer screening and triage of HPV positive women to colposcopy compared to liquid-based cytology (LBC) in an urban female population. METHODS: Women, aged 30-60, provided cervicovaginal samples at the Family-Planning Centre, Hippokratio Hospital of Thessaloniki, Greece, and the Department of Gynecology and Obstetrics in Mare Klinikum, Kiel, Germany...
March 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28337474/cervical-cancer-prevention-in-el-salvador-cape-an-hpv-testing-based-demonstration-project-changing-the-secondary-prevention-paradigm-in-a-lower-middle-income-country
#7
Mauricio Maza, Karla Alfaro, Jillian Garai, Mario Morales Velado, Julia C Gage, Philip E Castle, Juan Felix, Silvana Luciani, Nicole Campos, Jane Kim, Rachel Masch, Miriam Cremer
•CareHPV tests were used to compare screen-and-treat and colposcopy management.•Screen-and-treat strategy with HPV testing was found to be very cost-effective.•CAPE has screened > 25,000 women in the Paracentral region.•Over 70% of screen-positive women received recommended treatment within six months.•CAPE is an example of public-private partnership resulting in paradigm change.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28337373/heparanase-promotes-radiation-resistance-of-cervical-cancer-by-upregulating-hypoxia-inducible-factor-1
#8
Jianping Li, Xin Meng, Jing Hu, Ying Zhang, Yunzhi Dang, Lichun Wei, Mei Shi
Heparanase (HPSE1) is elevated in various types of cancers including cervical cancer, and correlated with poor prognosis. Current study is to investigate the effects of HPSE1 on radiation response in cervical cancer. Colony formation assays after radiation were performed to compare the radiation response among control, HPSE1 knockdown and HPSE1 overexpression HeLa cells. The mRNA and protein levels of HIF1, bFGF and VEGF were measured as indicators for the activity of HIF1 pathway. Xenograft mouse model were used to study the HPSE1 radiation regulator effects in vivo...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28337289/overexpression-of-trim24-is-correlated-with-the-progression-of-human-cervical-cancer
#9
Li Lin, Weihua Zhao, Bo Sun, Xinyu Wang, Qiao Liu
TRIM24, originally known as intermediary factor 1-alpha, is involved in the development of several cancers. This study aimed to evaluate the expression level and prognostic value of TRIM24 in cervical cancer. In the present study, we showed that the expression of TRIM24 was markedly upregulated in cervical cancer cell lines and cancerous specimens at both transcriptional and translational levels. TRIM24 expression was analyzed in 147 archived cervical cancer specimens using immunohistochemistry, and the correlation between TRIM24 expression and clinicopathological parameters was evaluated...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28337270/n-wasp-promotes-invasion-and-migration-of-cervical-cancer-cells-through-regulating-p38-mapks-signaling-pathway
#10
Jinxuan Hou, Hui Yang, Xin Huang, Xiaohua Leng, Fuxiang Zhou, Conghua Xie, Yunfeng Zhou, Yu Xu
Neural Wiskott-Aldrich syndrome protein (N-WASP) is an important member of the WASP family involved in the actin cytoskeleton reorganization. Recent evidence suggests that N-WASP may play important roles in tumor progression and metastasis. However, the contribution of N-WASP to cervical cancer is still unknown. The present study focused on elucidating the role of N-WASP in the malignant behavior of cervical cancer cells. We found that N-WASP overexpressed in cervical cancer tissues compared with paired paracancerous tissues and normal tissues, and similar results were observed in several cervical cancer cell lines...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28336252/trends-in-cervical-cancer-brachytherapy-volume-suggest-case-volume-is-not-the-primary-driver-of-poor-compliance-rates-with-brachytherapy-delivery-for-locally-advanced-cervical-cancer
#11
Daniel M Trifiletti, Surbhi Grover, Bruce Libby, Timothy N Showalter
PURPOSE: The aim of this study was to evaluate temporal trends in the volume of cervical cancer brachytherapy cases available to trainees as a potential contributing factor to national trends toward decreased utilization of brachytherapy for locally advanced cervical cancer. METHODS AND MATERIALS: The National Cancer Database was queried to identify a cohort of women diagnosed with locally advanced cervical cancer during 2004-2013 who received primary radiation therapy...
March 20, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28336133/comparison-of-cobas%C3%A2-hpv-and-anyplex%C3%A2-ii-hpv28-assays-for-detecting-and-genotyping-human-papillomavirus
#12
Christophe Pasquier, Karine Sauné, Stéphanie Raymond, Jérôme Boisneau, Monique Courtade, Jacques Izopet
Persistent infection with high-risk human papillomavirus (HPV-HR) is a recognized cause of cervical cancer. The aim of this study was to compare analytical and clinical performances of the Cobas® HPV and Anyplex™ II HPV28 assays for HPV detection and genotyping. A total of 94 cervical samples were tested. For HPV-HR, the results agreed very well (94.68%), with 100% agreement when detecting CIN2+. The Anyplex™ II HPV28 assay detected more genotypes than the Cobas® HPV Test, but their clinical performances were similar...
January 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28336131/modulating-the-dna-damage-response-to-improve-treatment-response-in-cervical-cancer
#13
L H Cossar, A G Schache, J M Risk, J J Sacco, N J Jones, R Lord
Cervical cancer is the fourth most common cause of cancer-related death in women worldwide and new therapeutic approaches are needed to improve clinical outcomes for this group of patients. Current treatment protocols for locally advanced and metastatic disease consist of ionising radiation and chemotherapy. Chemoradiation induces cytotoxic levels of DNA double-strand breaks, which activates programmed cell death via the DNA damage response (DDR). Cervical cancers are unique given an almost exclusive association with human papillomavirus (HPV) infection; a potent manipulator of the DDR, with the potential to alter tumour sensitivity to DNA-damaging agents and influence treatment response...
March 20, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28335890/cervical-cancer-incidence-in-elderly-women-biology-or-screening-history
#14
Elsebeth Lynge, Stefan Lönnberg, Sven Törnberg
AIM: In many countries, the age-specific pattern of cervical cancer incidence is currently bipolar with peaks at for instance 45 and 65 years of age. Consequently, a large proportion of cervical cancer cases are presently diagnosed in women above the screening age. The purpose of the study was to determine whether this bipolar pattern in age-specific incidence of cervical cancer reflects underlying biology or can be explained by the fact that the data come from birth cohorts with different screening histories...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28335363/antimicrobial-antioxidant-and-anticancer-activities-of-biosynthesized-silver-nanoparticles-using-marine-algae-ecklonia-cava
#15
Jayachandran Venkatesan, Se-Kwon Kim, Min Suk Shim
Green synthesis of silver nanoparticles (AgNPs) has gained great interest as a simple and eco-friendly alternative to conventional chemical methods. In this study, AgNPs were synthesized by using extracts of marine algae Ecklonia cava as reducing and capping agents. The formation of AgNPs using aqueous extract of Ecklonia cava was confirmed visually by color change and their surface plasmon resonance peak at 418 nm, measured by UV-visible spectroscopy. The size, shape, and morphology of the biosynthesized AgNPs were observed by transmission electron microscopy and dynamic light scattering analysis...
December 6, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335260/a-label-free-microelectrode-array-based-on-one-step-synthesis-of-chitosan-multi-walled-carbon-nanotube-thionine-for-ultrasensitive-detection-of-carcinoembryonic-antigen
#16
Huiren Xu, Yang Wang, Li Wang, Yilin Song, Jinping Luo, Xinxia Cai
Carcinoembryonic antigen (CEA) has been an extensively used tumor marker responsible for clinical early diagnosis of cervical carcinomas, and pancreatic, colorectal, gastric and lung cancer. Combined with micro-electro mechanical system (MEMS) technology, it is important to develop a novel immune microelectrode array (MEA) not only for rapid analysis of serum samples, but also for cell detection in vitro and in vivo. In this work, we depict a simple approach to modify chitosan-multi-walled carbon nanotubes-thionine (CS-MWCNTs-THI) hybrid film through one-step electrochemical deposition and the CS-MWCNTs-THI hybrid films are successfully employed to immobilize anti-CEA for fabricating simple, label-free, and highly sensitive electro-chemical immune MEAs...
July 11, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334854/the-burden-of-hpv-related-diseases-in-italy-2001-12
#17
P Kuhdari, S Previato, M Giordani, P Biavati, S Ferretti, G Gabutti
Background: Human papillomavirus (HPV) infection is the main cause of cervical cancer and plays a relevant role in the development of genital warts and of the cancer of penis and anus, head/neck, oropharynx and genitourinary system. The aim of this study is the evaluation of hospitalizations due to HPV-related pathologies in 2001-12 in Italy. Methods: The national hospital discharge forms were provided by the Ministry of Health. The HPV-related hospitalizations were identified using specific diagnostic codes, accordingly to the ICD-9-CM coding system...
March 14, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28334837/clinical-outcome-of-definitive-radiation-therapy-for-superficial-esophageal-cancer
#18
Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh, Shinji Naganawa
Objective: To analyze the clinical outcome of concurrent chemoradiotherapy in superficial esophageal cancer patients. Methods: We retrospectively analyzed data for 123 patients with superficial esophageal cancer who received external beam radiotherapy without intracavitary brachytherapy plus systemic chemotherapy during 1998-2015. Elective nodal irradiation was not performed. The dosage to planning treatment volume was 60 Gy in 30 fractions. The main outcome measure was overall survival...
February 23, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28334835/screening-utilization-among-cancer-survivors-a-meta-analysis
#19
Annemarie Uhlig, Janet Mei, Inhye Baik, Christian Meyer, Johannes Uhlig
Background: Studies have been published showing both increased and decreased utilization of cancer screening services in cancer survivors compared with cancer-free counterparts. This study synthesizes existing evidence in a meta-analysis. Methods: A systematic literature review was conducted in August 2016. Studies were included if they compared the utilization of screening services for cervical, breast and colorectal cancer among adulthood cancer survivors to cancer-free controls...
March 14, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28333846/prognostic-value-of-fluorine-18-fluorodeoxyglucose-uptake-of-bone-marrow-on-positron-emission-tomography-computed-tomography-for-prediction-of-disease-progression-in-cervical-cancer
#20
Jeong Won Lee, Seob Jeon, Seong Taek Mun, Sang Mi Lee
OBJECTIVE: This study aimed to evaluate the prognostic value of fluorine-18 fluorodeoxyglucose (FDG) uptake of bone marrow (BM) on positron emission tomography (PET)/computed tomography in patients with uterine cervical cancer. METHODS: One hundred forty-five patients with cervical cancer who underwent staging FDG PET/computed tomography and subsequent surgical resection or chemoradiotherapy were retrospectively enrolled in the study. Mean BM FDG uptake (BM standardized uptake value [SUV]) and BM-to-liver uptake ratio of FDG uptake (BLR) were measured...
March 23, 2017: International Journal of Gynecological Cancer
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