keyword
https://read.qxmd.com/read/38537211/68ga-dota-iba-uptake-in-breast-cancer
#1
JOURNAL ARTICLE
Feifan Xiang, Huipan Liu, Xiaoqi Tan, Yue Chen
A 77-year-old woman with recently diagnosed breast cancer underwent 68Ga-labeled DOTA-ibandronic acid (68Ga-DOTA-IBA) PET/CT scan for the evaluation of bone metastases. The examination revealed increased tracer uptake, indicating that the cervical vertebrae presented osteoblastic metastasis. Interestingly, the breast cancer also showed enhanced activity of 68Ga-DOTA-IBA.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38536591/circ_0020460-drives-tumorigenesis-in-cervical-cancer-through-mir-485-3p-sponging
#2
JOURNAL ARTICLE
Kun Yan, Chunyan Hu, Yali Cheng, Lingzhi Zheng, Baojin Zeng, Sujun Zhao, Chen Liu
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay, wound healing assay, transwell assay, flow cytometry assay, and tube formation assay, respectively...
March 27, 2024: Discover. Oncology
https://read.qxmd.com/read/38536579/cell-cycle-related-protein-centromere-protein-f-deficiency-inhibits-cervical-cancer-cell-growth-by-inducing-ferroptosis-via-nrf2-inactivation
#3
JOURNAL ARTICLE
Xin Hui Tang, Tian Nan Zhao, Li Guo, Xin Yue Liu, Wei Na Zhang, Ping Zhang
Cervical cancer (CC) is one of the severe cancers that pose a threat to women's health and result in death. CENPF, the centromere protein F, plays a crucial role in mitosis by regulating numerous cellular processes, such as chromosome segregation during mitosis. According to bioinformatics research, CENPF serves as a master regulator that is upregulated and activated in cervical cancer. Nevertheless, the precise biological mechanism that CENPF operates in CC remains unclear. The aim of this study was to analyze the function of CENPF on cervical cancer and its mechanism...
March 27, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38536425/integrated-pretreatment-diffusion-kurtosis-imaging-and-serum-squamous-cell-carcinoma-antigen-levels-a-biomarker-strategy-for-early-assessment-of-radiotherapy-outcomes-in-cervical-cancer
#4
JOURNAL ARTICLE
Xiang Zheng, Fangmin Shen, Wenjuan Chen, Wang Ren, Shaoliang Tang
OBJECTIVE: This study aims to explore the utility of pretreatment DKI parameters and serum SCC-Ag in evaluating the early therapeutic response of cervical cancer to radiotherapy. MATERIALS AND METHODS: A total of 33 patients diagnosed with cervical cancer, including 31 cases of cervical squamous cell carcinoma and two cases of adenosquamous carcinoma, participated in the study. All patients underwent conventional MRI and DKI scans on a 3T magnetic resonance scanner before radiotherapy and after ten sessions of radiotherapy...
March 27, 2024: Abdominal Radiology
https://read.qxmd.com/read/38536211/individual-and-geospatial-determinants-of-health-associated-with-school-based-human-papillomavirus-immunization-in-alberta-population-based-cohort-study
#5
JOURNAL ARTICLE
Jennifer Malkin, Geneviève Jessiman-Perreault, Amanda Alberga Machado, Gary Teare, Joanne Snider, Syed Farhan Tirmizi, Erik Youngson, Ting Wang, Jessica Law, Thilina Bandara, Mika Rathwell, Cordell Neudorf, Lisa Allen Scott
BACKGROUND: Human papillomavirus (HPV) infection causes nearly all cervical cancer cases and is a cause of anogenital and oropharyngeal cancers. The incidence of HPV-associated cancers is inequitable, with an increased burden on marginalized groups in high-income countries. Understanding how immunization status varies by material and social deprivation, health system, and geospatial factors is valuable for prioritizing and planning HPV immunization interventions. OBJECTIVE: The objective of this study was to describe school-based HPV immunization rates by individual and geospatial determinants of health in Alberta, Canada...
March 27, 2024: JMIR Public Health and Surveillance
https://read.qxmd.com/read/38535586/unveiling-the-dual-threat-how-microbial-infections-and-healthcare-deficiencies-fuel-cervical-and-prostate-cancer-deaths-in-africa
#6
REVIEW
Sofian Abdul-Nasir, Hyungdon Lee, Md Habibur Rahman, Johny Bajgai, Kyu-Jae Lee, Cheol-Su Kim, Soo-Ki Kim
Cervical and prostate cancer account for 7.1 and 7.3 deaths per 100,000 people globally in 2022. These rates increased significantly to 17.6 and 17.3 in Africa, respectively, making them the second and third leading cause of cancer deaths in Africa, only surpassed by breast cancer. The human papillomavirus is the prime risk factor for cervical cancer infection. On the other hand, prostate cancer risks include ageing, genetics, race, geography, and family history. However, these factors alone cannot account for the high mortality rate in Africa, which is more than twice the global mortality rate for the two cancers...
March 10, 2024: Pathogens
https://read.qxmd.com/read/38535552/human-papillomavirus-hpv-infection-and-risk-behavior-in-vaccinated-and-non-vaccinated-paraguayan-young-women
#7
JOURNAL ARTICLE
María Liz Bobadilla, Verónica Villagra, Héctor Castro, Marta von Horoch, Soraya Araya, Gerardo Deluca, Vanessa Salete de Paula
Cervical cancer is a global health concern and ranks fourth among the most prevalent cancers in women worldwide. Human papillomavirus (HPV) infection is a known precursor of cervical cancer and preventive measures include prophylactic vaccines. This study focused on sexually active Paraguayan women aged 18-25 years, exploring the intersection of HPV vaccination and sexual behavior. Among 254 participants, 40.9% received the Gardasil-4 vaccine, with no significant differences in sexual behavior between the vaccinated and unvaccinated sexually active groups...
February 27, 2024: Pathogens
https://read.qxmd.com/read/38535267/a-comprehensive-study-on-folate-targeted-mesoporous-silica-nanoparticles-loaded-with-5-fluorouracil-for-the-enhanced-treatment-of-gynecological-cancers
#8
JOURNAL ARTICLE
Aliyah Almomen, Adel Alhowyan
BACKGROUND: Gynecological cancers are a significant public health concern, accounting for 40% of all cancer incidence and 30% of deaths in women. 5-Fluorouracil (5-FU) can be used with chemotherapy to improve treatment in advanced-stage gynecological cancer. Mesoporous silica nanoparticles (MSNs) can improve drug effectiveness and reduce toxicity. Folic acid can target folate receptors in epithelial malignancies like ovarian and cervical cancer. METHODS: The mixture of MSN-NH2 was synthesized by dissolving N-lauroylsarcosine sodium in a water-ethanol mixture, adding APTES and TEOS, and heating at 80 °C for 18 h, before being fully characterized...
March 20, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535031/assessment-of-cervicovaginal-smear-and-hpv-dna-co-test-for-cervical-cancer-screening-implications-for-diagnosis-and-follow-up-strategies
#9
JOURNAL ARTICLE
Neslihan Kaya Terzi, Ozden Yulek
OBJECTIVE: Cervical cancer is a major cause of cancer-related mortality, necessitating effective screening and diagnostic methods. This study aimed to assess the performance of cervicovaginal smear (CVS) and human papillomavirus (HPV)-DNA co-test. STUDY DESIGN: The pathology results of 225 female patients who underwent HPV-DNA testing with CVS between 2014 and 2022 and were subsequently diagnosed by colposcopic cervical biopsy or second CVS were retrospectively analyzed...
March 13, 2024: Diagnostics
https://read.qxmd.com/read/38534790/the-role-of-urothelial-cancer-associated-1-in-gynecological-cancers
#10
REVIEW
Eleni Nousiopoulou, Kleio Vrettou, Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Panagiotis Tsikouras, Nikolaos Nikolettos, Konstantinos Nikolettos, Iason Psilopatis
Gynecological cancers (GC) represent some of the most frequently diagnosed malignancies in women worldwide. Long-non-coding RNAs (lncRNAs) are regulatory RNAs increasingly being recognized for their role in tumor progression and metastasis in various cancers. Urothelial cancer-associated 1 (UCA1) is a lncRNA, first found deregulated in bladder cancer, and many studies have exposed its oncogenic effects in more tumors since. However, the role of UCA1 in gynecological malignancies is still unclear. This review aims to analyze and define the role of UCA1 in GC, in order to identify its potential use as a diagnostic, prognostic, or therapeutic biomarker of GC...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534098/a-novel-mitochondria-related-core-gene-signature-to-predict-the-prognosis-and-evaluate-tumour-microenvironment-in-cesc-single-cell-validation
#11
JOURNAL ARTICLE
Lingxiao Ying, Lin Kong, Xiaoxiao Qiu, Aihua Cheng, Qijun Wang, Limeng Xiu, Jinmei Shi, Yanfei Tao, Zhihong Chai
Mitochondria and their related genes (MTRGs) are pivotal in the tumour microenvironment (TME) of cervical cancer, influencing prognosis and treatment response. This study developed a prognostic model using MTRGs to predict overall survival (OS) in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), aiming for personalized therapy. Analysing 14 MTRGs like ISCU and NDUFA11 through techniques such as univariate Cox regression, we found that a low mitochondrial (MT) score is associated with better survival, while a high MT score predicts poorer outcomes...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38533898/effective-vaccination-strategies-for-human-papillomavirus-hpv-infection-and-cervical-cancer-based-on-the-mathematical-model-with-a-stochastic-process
#12
JOURNAL ARTICLE
Minsoo Kim, Eunjung Kim
Human papillomavirus (HPV) infection poses a significant risk to women's health by causing cervical cancer. In addition to HPV, cervical cancer incidence rates can be influenced by various factors, including human immunodeficiency virus and herpes, as well as screening policy. In this study, a mathematical model with stochastic processes was developed to analyze HPV transmission between genders and its subsequent impact on cervical cancer incidence. The model simulations suggest that both-gender vaccination is far more effective than female-only vaccination in preventing an increase in cervical cancer incidence...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38533459/lives-saved-through-increasing-adherence-to-follow-up-after-abnormal-cervical-cancer-screening-results
#13
JOURNAL ARTICLE
Diane M Harper, Tiffany M Yu, A Mark Fendrick
OBJECTIVE: To model the potential number of cancers prevented and life-years saved over a range of adherence rates to cervical cancer screening, surveillance follow-up, and follow-up colposcopy that may result from removing financial barriers to these essential clinical services. METHODS: A previously validated decision-analytic Markov microsimulation model was used to evaluate the increase in adherence to screening, surveillance, and colposcopy after an abnormal cervical cancer screening result...
March 2024: O G Open
https://read.qxmd.com/read/38533391/personality-and-the-use-of-cancer-screenings-results-of-the-german-national-cohort
#14
JOURNAL ARTICLE
André Hajek, Heiko Becher, Hermann Brenner, Bernd Holleczek, Verena Katzke, Rudolf Kaaks, Heike Minnerup, André Karch, Hansjörg Baurecht, Michael Leitzmann, Annette Peters, Sylvia Gastell, Wolfgang Ahrens, Ulrike Haug, Katharina Nimptsch, Tobias Pischon, Karin B Michels, Anja Dorrn, Carolina J Klett-Tammen, Stefanie Castell, Stefan N Willich, Thomas Keil, Sabine Schipf, Claudia Meinke-Franze, Volker Harth, Nadia Obi, Hans-Helmut König
OBJECTIVE: To determine the association between personality characteristics and use of different cancer screenings. METHODS: We used data from the German National Cohort (NAKO; mean age was 53.0 years (SD: 9.2 years)) - a population-based cohort study. A total of 132,298 individuals were included in the analyses. As outcome measures, we used (self-reported): stool examination for blood (haemoccult test, early detection of bowel cancer), colonoscopy (screening for colorectal cancer), skin examination for moles (early detection of skin cancer), breast palpation by a doctor (early detection of breast cancer), x-ray examination of the breast ("mammography", early detection of breast cancer), cervical smear test, finger examination of the rectum (early detection of prostate cancer), and blood test for prostate cancer (determination of Prostate-Specific Antigen level)...
May 2024: Preventive Medicine Reports
https://read.qxmd.com/read/38533371/cutaneous-metastases-of-cervical-cancer-a-rare-entity-and-possible-mechanisms-of-dissemination
#15
JOURNAL ARTICLE
Ana Popovic, Milica Djurovic Bojic, Milos Bojic, Filip Vukmirovic, Aleksandar Juskovic
No abstract text is available yet for this article.
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38532933/novel-biomarkers-of-inflammation-associated-immunity-in-cervical-cancer
#16
JOURNAL ARTICLE
Weihong Zhao, Qi Li, Songquan Wen, Yaqin Li, Ying Bai, Zhiyu Tian
BACKGROUND: Cervical cancer (CC) is a highly malignant gynecological cancer with a direct causal link to inflammation, primarily resulting from persistent high-risk human papillomavirus (HPV) infection. Given the challenges in early detection and mid to late-stage treatment, our research aims to identify inflammation-associated immune biomarkers in CC. METHODS: Using a bioinformatics approach combined with experimental validation, we integrated two CC datasets (GSE39001 and GSE63514) in the Gene Expression Omnibus (GEO) to eliminate batch effects...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38532929/-there-is-nothing-that-can-prevent-me-from-supporting-her-men-s-perspectives-on-their-involvement-and-support-of-women-s-use-of-topical-therapy-for-cervical-precancer-treatment-in-kenya
#17
JOURNAL ARTICLE
Chemtai Mungo, Konyin Adewumi, Everlyn Adoyo, Graham Zulu, Supreet Kaur Goraya, Cirillus Ogollah, Jackton Omoto, Renée M Ferrari, Lisa Rahangdale
PURPOSE: Cervical cancer disproportionately impacts women in low- and middle-income countries (LMICs). The World Health Organization's (WHO) 90/70/90 strategy aims to eliminate cervical cancer by 2030 by increasing HPV vaccination coverage to 90%, screening 70% of eligible women, and effectively treating 90% of those with abnormal results by 2030, potentially preventing 62 million deaths in LMICs. LMICs, however, struggle with limited access to cervical precancer treatment, in part due to a lack of trained professionals and weak health systems...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38531541/sustainability-of-an-enhanced-recovery-pathway-after-minimally-invasive-gynecologic-oncology-surgery
#18
JOURNAL ARTICLE
Anna McCracken, Rachel Soyoun Kim, Stephane Laframboise, Manjula Maganti, Marcus Q Bernardini, Sarah Ferguson, Liat Hogen, Taymaa May, Stuart A McCluskey, Geneviève Bouchard-Fortier
OBJECTIVE: Same day discharge is safe after minimally invasive gynecology oncology surgery. Our quality improvement peri-operative program based on enhanced recovery after surgery principles led to an increase in same day discharge from 30% to 75% over a 12 month period. Twelve months after program implementation, we assessed the sustainability of same day discharge rates, determined post-operative complication rates, and evaluated factors affecting same day discharge rates. METHODS: A retrospective chart review was conducted of 100 consecutive patients who underwent minimally invasive surgery at an academic cancer center from January to 2021 to December 2021...
March 26, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38530846/a-phase-i-trial-of-nab-paclitaxel-bevacizumab-ab160-nano-immunoconjugate-therapy-for-gynecologic-malignancies
#19
JOURNAL ARTICLE
Eleftheria Kalogera, Wendy K Nevala, Heidi D Finnes, Vera J Suman, Jill M Schimke, Carrie A Strand, Lisa A Kottschade, Rachel A Kudgus, Sarah A Buhrow, Laura R Becher, Liyi Geng, Gretchen E Glaser, Megan E Grudem, Aminah Jatoi, Carolyn M Klampe, Amanika Kumar, Carrie L Langstraat, Robert R McWilliams, Andrea E Wahner Hendrickson, S John Weroha, Yiyi Yan, Joel M Reid, Svetomir N Markovic, Matthew S Block
PURPOSE: AB160 is a 160 nm nano-immunoconjugate consisting of nab-paclitaxel (ABX) nanoparticles non-covalently coated with bevacizumab (BEV) for targeted delivery into tissues expressing high levels of VEGF. Preclinical data showed that AB160 resulted in greater tumor targeting and tumor inhibition compared to sequential treatment with ABX then BEV. Given individual drug activity, we investigated the safety and toxicity of AB160 in patients with gynecologic cancers. PATIENTS AND METHODS: A 3+3 phase I trial was conducted with 3 potential dose levels in patients with previously treated endometrial (EC), cervical (CC), and platinum-resistant ovarian cancer (OC) patients to ascertain the recommended Phase II dose (RP2D)...
March 26, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38530569/mri-based-volumetric-tumor-parameters-before-and-during-chemoradiation-predict-tumor-recurrence-and-patient-survival-in-locally-advanced-cervical-cancer-a-subgroup-analysis-of-a-phase-ii-prospective-trial
#20
JOURNAL ARTICLE
Han Byul Kang, Sung Hwan Kim, Joo Hwan Lee, Hyo Chun Lee, Nam Kyu Kang, Jong Hoon Lee
BACKGROUND: This subgroup analysis of a prospective phase II trial aimed to identify valuable and accessible prognostic factors for overall survival (OS) and progression-free survival (PFS) of patients with locally advanced cervical cancer (LACC). METHODS: Patients with FIGO II to IVA cervical cancer were assessed in this study. All patients underwent concurrent chemoradiotherapy (CCRT) followed by brachytherapy. Tumor parameters based on MRI scans before and during CCRT were evaluated for Overall survival (OS) and Progression-free survival (PFS)...
March 26, 2024: International Journal of Clinical Oncology
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