Michel Azizi, Manish Saxena, Yale Wang, J Stephen Jenkins, Chandan Devireddy, Florian Rader, Naomi D L Fisher, Roland E Schmieder, Felix Mahfoud, Jason Lindsey, Kintur Sanghvi, Thomas M Todoran, John Pacella, John Flack, Joost Daemen, Andrew S P Sharp, Philipp Lurz, Michael J Bloch, Michael A Weber, Melvin D Lobo, Jan Basile, Lisa Claude, Helen Reeve-Stoffer, Candace K McClure, Ajay J Kirtane
IMPORTANCE: Two initial sham-controlled trials demonstrated that ultrasound renal denervation decreases blood pressure (BP) in patients with mild to moderate hypertension and hypertension that is resistant to treatment. OBJECTIVE: To study the efficacy and safety of ultrasound renal denervation without the confounding influence of antihypertensive medications in patients with hypertension. DESIGN, SETTING, AND PARTICIPANTS: Sham-controlled, randomized clinical trial with patients and outcome assessors blinded to treatment assignment that was conducted between January 14, 2019, and March 25, 2022, at 37 centers in the US and 24 centers in Europe, with randomization stratified by center...
February 28, 2023: JAMA