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Brest Diagnostics

Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis, Solène Querellou
BACKGROUND: xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images with bone anatomy appearance. The objectives of this study were to assess xB/CT reconstruction diagnostic reliability and accuracy in comparison with Flash 3D® (F3D)/CT in clinical routine. Two hundred thirteen consecutive patients referred to the Brest Nuclear Medicine Department for non-oncological bone diseases were evaluated retrospectively...
February 12, 2018: EJNMMI Research
C Le Niger, C André, V Bourcier, L Augey, A Bazin, E Berger, V Betbeze, A Damais-Cepitelli, G Daurat, E De Meyer, S Ducroz, H Gouezec, C Huchet, B Lassale, S Leo-Kodeli, V Lovi, M Puntous, S Pujol, P Renom, C Rieux
The decision of November 6th, 2006 defining the principles of best practices recommends that posttransfusional red cell alloantibodies research is performed after one to three months after. In the University hospital of Brest, the haemovigilance unit takes charge of sending the medical prescription within the required time and centralizing the results. We wished to estimate if the realization of this research still remains relevant. METHODS: A prospective analysis was performed in 2015...
February 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
P Šašková, D Pavlišta
OBJECTIVE: The rising number of breast cancer is the worldwide problem. The screening mammography is considered as the most effective method to decrease the mortality of the disease. For many years, the breast self-examination has been promoted as the simplest method for breast cancer development in women. In this review article, we provide the results of studies on the effectiveness of breast self-examination. DESIGN: Review article. SETTING: Departmnet of Gynecologic and Obstetrition, General Faculty Hospital and 1st Faculty of Medicine, Charles University Prague...
December 0: Ceská Gynekologie
Adrien Basset, Emmanuel Nowak, Philippe Castellant, Christophe Gut-Gobert, Grégoire Le Gal, Erwan L'Her
OBJECTIVE: To derive and validate a clinical prediction rule of acute congestive heart failure obtainable in the emergency care setting. DESIGN: Derivation of the score was performed on a retrospective 927 patients cohort admitted to our Emergency Department for dyspnea. The prediction model was externally validated on an independent 206-patient prospective cohort. INTERVENTIONS AND MEASURES: During the derivation phase, variables associated with acute congestive heart failure were included in a multivariate regression model...
December 2016: American Journal of Emergency Medicine
M-C Boeuf, G Rohel, G Lamour, M Piquemal, N Paleiron, X Fouilland, C Le Nestour, U Vinsonneau, S Paez, P Paule
UNLABELLED: The finding of a systolic heart murmur is common in medical military practice. Albeit often benign among young healthy adults, it can reveal a valvular or a cardiac disease, which could worsen during workout or expose to risk of a sudden death. This study aims to evaluate the diagnostic efficiency of the military general practitioner when discovering a systolic murmur among young asymptomatic patients. MATERIALS AND METHODS: During one year, this study involved all the general practitioners of the medical military centres of Brittany and the cardiologists of the military hospital in Brest...
November 2015: Annales de Cardiologie et D'angéiologie
N Guibert, M Ilie, E Long, V Hofman, L Bouhlel, P Brest, B Mograbi, C H Marquette, A Didier, J Mazieres, P Hofman
KRAS mutations are detected in over one third of lung adenocarcinomas, most frequently in Caucasian and smoker patients. The impact of KRAS mutations on lung adenocarcinoma prognosis is currently subject to debate, as is their impact on the response to chemotherapy and EGFR tyrosine kinase inhibitors. The different methods for KRAS status assessment, based on histological and cytological samples or biological fluids, offer varying sensitivities. Since no treatments are available in clinical routine for KRAS-mutated lung cancer patients, one of the current major challenges in thoracic oncology is developing new dedicated strategic therapies...
2015: Current Molecular Medicine
Philippe Robin, Ronan Abgral, Gérald Valette, Pierre-Yves Le Roux, Nathalie Keromnes, Jean Rousset, Gaël Potard, Xavier Palard, Rémi Marianowski, Pierre-Yves Salaun
PURPOSE: Posttreatment follow-up for the recurrence of head and neck squamous cell carcinoma (HNSCC) is a diagnostic challenge. Tissue distortion from radiation and surgery can obscure early detection of recurrence by conventional follow-up approaches such as physical examination or conventional imaging. Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT is widely validated for the diagnosis of suspected recurrence. Moreover, we have shown in a previous prospective study the high effectiveness of FDG PET/CT in the assessment of subclinical recurrence 12 months after treatment...
January 2015: European Journal of Nuclear Medicine and Molecular Imaging
Pierre-Yves Le Roux, Xavier Palard, Philippe Robin, Aurélien Delluc, Ronan Abgral, Solène Querellou, Francis Couturaud, Grégoire Le Gal, Pierre-Yves Salaun
PURPOSE: The aim of this management outcome study was to assess the safety of ventilation/perfusion single photon emission computed tomography (V/Q SPECT) for the diagnosis of pulmonary embolism (PE) using for interpretation the criteria proposed in the European Association of Nuclear Medicine (EANM) guidelines for V/Q scintigraphy. METHODS: A total of 393 patients with clinically suspected PE referred to the Nuclear Medicine Department of Brest University Hospital from April 2011 to March 2013, with either a high clinical probability or a low or intermediate clinical probability but positive D-dimer, were retrospectively analysed...
October 2014: European Journal of Nuclear Medicine and Molecular Imaging
Philippe Saliou, Gérald Le Gac, Anne-Yvonne Mercier, Brigitte Chanu, Paul Guéguen, Marie-Christine Mérour, Isabelle Gourlaouen, Sandrine Autret, Cédric Le Maréchal, Karen Rouault, Jean-Baptiste Nousbaum, Claude Férec, Virginie Scotet
Despite type I haemochromatosis (HC) is mainly associated with the HFE C282Y/C282Y genotype, a second genotype -C282Y/H63D- has mostly been described in other patients. Its association with HC, apart from any associated co-morbid factors, remains unclear and complex to interpret for physicians. This study assesses the weight of this genotype and the role of co-morbid factors in the occurrence of iron overload. This prospective study included the C282Y/C282Y (n = 172) and C282Y/H63D (n = 58) patients enrolled in a phlebotomy program between 2004 and 2007 in a blood centre of western Brittany (Brest, France), where HC is frequent...
2013: PloS One
L Večeřová, M Bendová
DESIGN: This is a retrospective study evaluating the minimum detection cancers in the group of women mammographically examined in our department. The study covers the period from 1. 1. 2012 to 31. 12. 2012. Interestingly we introduced several interesting case studies. OBJECTIVE: 1. Confirmation upward trend in the number of minimal breast cancers, stage T1. 2. The need for multidisciplinary cooperation for quick minimal surgical intervention and effective cancer treatment...
August 2013: Ceská Gynekologie
E Masson-Le Guen, C Cochard-Marianowski, R Macarez, J-F Charlin, B Cochener
AIMS: To evaluate the neuro-ophthalmological assessments carried out in the ophthalmology department of the university medical center, Brest, identifying the population seen, the examinations performed, the pathologies treated and patient outcomes, so as to suggest solutions to improve quality of care. METHODOLOGY: Retrospective study over a period of more than five years, between January 1st, 2004 and October 31st, 2009. Data were collected from each patient's chart with the help of a standardized spreadsheet including epidemiological, clinical, paraclinical and treatment data...
December 2012: Journal Français D'ophtalmologie
M Carpentier, V Appere, P Saliou, A de Tinteniac, H Floch, F Le Gall, M Cosse, M El Bouyousfi, R Baron, J-M Boles, S Jourdain, B Lejeune, B Nancy, G Prat, D Tande, M Virmaux, J-P Wargnier, R Garlantézec
INTRODUCTION: We had for aim to describe control and investigation of an outbreak caused by a strain of Extended spectrum beta-lactamase producing Klebsiella pneumoniae in intensive care units of the Brest teaching hospital. PATIENTS AND METHOD: The case definition was a patient infected by or carrying the epidemic strain. Control measures and investigations are presented. A case-control study was conducted in the surgical intensive care unit. Each case was matched with two controls based on admission times in the unit...
October 2012: Médecine et Maladies Infectieuses
Maria-Antonietta D'Agostino, Alain Saraux, Isabelle Chary-Valckenaere, Christian Marcelli, Sandrine Guis, Philippe Gaudin, Philippe Aegerter, Sandrine Jousse-Joulin, Damien Loeuille, Olivia Judet, Bertrand Lecoq, Cécile Hacquard-Bouder, Laurent Grange, Marie Caroline Guzian, Alain Blum, Christophe Chagnaud, Ariane Leboime, Dominique Monnet, Anne-Christine Rat, Marie Agnès Timsit, Roula Said-Nahal, Maxime Breban
UNLABELLED: Power Doppler ultrasound (PDUS) has proved to be a highly sensitive tool for assessing enthesitis in spondyloarthritis (SpA). In patients with a suspected SpA, diagnosis could be improved by detecting enthesitis with PDUS. OBJECTIVE: To evaluate the performance of PDUS for the diagnosis of SpA alone or combined with other clinical, laboratory and imaging findings in patients consulting for a suspected SpA. METHODS: Prospective, multicenter French cohort study (Boulogne-Billancourt, Brest, Caen, Grenoble, Marseille and Nancy)...
December 2012: Joint, Bone, Spine: Revue du Rhumatisme
Gwénolé Quellec, Mathieu Lamard, Guy Cazuguel, Lynda Bekri, Wissam Daccache, Christian Roux, Béatrice Cochener
PURPOSE: Recent studies on diabetic retinopathy (DR) screening in fundus photographs suggest that disagreements between algorithms and clinicians are now comparable to disagreements among clinicians. The purpose of this study is to (1) determine whether this observation also holds for automated DR severity assessment algorithms, and (2) show the interest of such algorithms in clinical practice. METHODS: A dataset of 85 consecutive DR examinations (168 eyes, 1176 multimodal eye fundus photographs) was collected at Brest University Hospital (Brest, France)...
2011: Investigative Ophthalmology & Visual Science
Iryna Shimanskaya, Larisa Zhurauskaya, Oleg Pankratov, Magnus Unemo, Ronald C Ballard, Marius Domeika
The performance of three serological tests manufactured in Belarus for the diagnosis of syphilis, i.e. a microprecipitation reaction (MPR) and two enzyme-linked immunosorbent assays (ELISAs) were compared with internationally recognized assays, namely the rapid plasma reagin test and the Treponema pallidum passive particle agglutination assay (TPPA). Sera from 392 consecutive patients attending Brest (Belarus) regional dermatovenereological dispensaries were tested. The sensitivity of the MPR test was low (77...
May 2011: Acta Dermato-venereologica
S Saint-André, W Neira Zalentein, D Robin, A Lazartigues
INTRODUCTION: The authors report on the set-up of a telehealth system developed to facilitate exchanges between the Autism Resource Centre of Brittany (centre de ressources pour l'autisme [CRA]) located in Brest and an adult psychiatry structure of Vannes' Hospital in the Morbihan region, these sites are about 200 kilometres distant. OBJECTIVES: This coordinated work using computer networks aims at sustaining the action of a unit specialised in autistic patients...
February 2011: L'Encéphale
Ivica Pejcić, Svetislav Vrbić, Sladjana Filipović, Mirjana Sćekić, Ivan Petković, Ljiljana Pejcić, Nebojsa Djenić
BACKGROUND/AIM: Unknown primary tumors represent a heterogeneous group of malignancies that are indicative of ominous prognosis. Cancer of unknown primary site (CUP) is defined as the lack of any detectable primary site after full evaluation, and accounts for approximately 3-5% of all newly diagnosed patients with malignancies. The aim of this report was to present the prognostic and predictive value of 8 serum tumor markers in this group of patients. METHODS: The study involved 63 patients...
September 2010: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Pierre-Yves Salaun, Francis Couturaud, Alexandra Le Duc-Pennec, Karine Lacut, Pierre-Yves Le Roux, Philippe Guillo, Pierre-Yves Pennec, Jean-Christophe Cornily, Christophe Leroyer, Grégoire Le Gal
BACKGROUND: We designed a simple and integrated diagnostic algorithm for acute pulmonary embolism (PE). Diagnosis was based on clinical probability assessment, plasma D-dimer testing, then sequential testing to include lower limb venous compression ultrasonography, ventilation perfusion lung scan, and chest multidetector CT (MDCT) imaging. METHODS: We included 321 consecutive patients presenting at Brest University Hospital in Brest, France, with clinically suspected PE and positive d-dimer or high clinical probability...
June 2011: Chest
Johanne Morvan, Françoise Charles-Petillon, Valérie Devauchelle-Pensec, Sandrine Jousse-Joulin, Alain Saraux
OBJECTIVE: This study aims to evaluate the interest to systematically combine cytology and histology for all bone specimens. METHODS: We reviewed all the bone biopsies performed in the University Hospital of Brest, France, between January 2000 and March 2008 and for which cytology and histology, obtained at the same time, were available. The interest of cytology and histology, alone and in combination was studied in comparison with the diagnostic made by the practitioner who treated the patient, which was considered the reference...
October 2010: Joint, Bone, Spine: Revue du Rhumatisme
Sandra Lassalle, Véronique Hofman, Ilie Marius, Virginie Gavric-Tanga, Patrick Brest, Katia Havet, Catherine Butori, Eric Selva, José Santini, Baharia Mograbi, Paul Hofman
BACKGROUND: With the advent of the formaldehyde standard law in France, and because of the impact of new methods for diagnosis and prognosis in pathology, formalin replacement in surgical pathology laboratories is currently being discussed in France. However, a set of criteria must be assessed before introducing a formalin substitute fixative. The objective of this study was to compare formalin substitute fixation with formalin fixation and cryoconservation of tissues from several benign and malignant thyroid pathologies with respect to morphology, antigenicity, and nucleic acid (RNA, DNA, microRNA) integrity...
November 2009: Thyroid: Official Journal of the American Thyroid Association
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