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https://www.readbyqxmd.com/read/28230281/resveratrol-enhances-self-renewal-of-mouse-embryonic-stem-cells
#1
Na Li, Zhaoyu Du, Qiaoyan Shen, Qijing Lei, Ying Zhang, Mengfei Zhang, Jinlian Hua
Resveratrol (RSV) has been shown to affect the differentiation of several types of stem cells, while the detailed mechanism is elusive. Here, we aim to investigate the function of RSV in self-renewal of mouse embryonic stem cells (ESCs) and the related mechanisms. In contrast with its reported roles, we found unexpectedly that differentiated ESCs or iPSCs treated by RSV would not show further differentiation, but regained a naïve pluripotency state with higher expressions of core transcriptional factors and with the ability to differentiate into all three germ layers when transplanted in vivo...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28223934/plasma-cystatin-c-and-high-density-lipoprotein-are-important-biomarkers-of-alzheimer-s-disease-and-vascular-dementia-a-cross-sectional-study
#2
Rui Wang, Zhaoyu Chen, Yongmei Fu, Xiaobo Wei, Jinchi Liao, Xu Liu, Bingjun He, Yunqi Xu, Jing Zou, Xiaoyan Yang, Ruihui Weng, Sheng Tan, Christopher McElroy, Kunlin Jin, Qing Wang
: Objectives: Cystatin C (Cys C) and high-density lipoprotein (HDL) play critical roles in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and vascular dementia (VaD). However, whether they can be used as reliable biomarkers to distinguish patients with dementia from healthy subjects and to determine disease severity remain largely unknown. Methods: We conducted a cross-sectional study to determine plasma Cys C and HDL levels of 88 patients with dementia (43 AD patients, 45 VaD patients) and 45 healthy age-matched controls...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28204824/dna-methylation-mediated-caspase-8-downregulation-is-associated-with-anti-apoptotic-activity-and-human-malignant-glioma-grade
#3
Yueqiu Teng, Yu-Cui Dong, Zhaoyu Liu, Yan Zou, Hui Xie, Yu Zhao, Jun Su, Fenglin Cao, Hua Jin, Huan Ren
The methylation-mediated silencing of tumor suppressors, including key apoptosis-related genes plays an important role in the pathogenesis and therapeutic resistance in human cancer. In this study, we aimed to elucidate the role and mechanisms of resistance to apoptosis with caspase-8 gene downregulation in human malignant glioma. Reverse transcription-polymerase chain reaction (RT-PCR) and methylation-specific PCR (MSP) were used to examine caspase-8 expressoin at the mRNA level and gene methylation status in normal brain tissue, glioma tissue and cancer cell lines...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28193032/transcription-factor-response-elements-on-tip-a-sensitive-approach-for-large-scale-endogenous-transcription-factor-quantitative-identification
#4
Wenhao Shi, Kai Li, Lei Song, Mingwei Liu, Yunzhi Wang, Wanlin Liu, Xia Xia, Zhaoyu Qin, Bei Zhen, Yi Wang, Fuchu He, Jun Qin, Chen Ding
The ability to map endogenous transcription factors (TFs) DNA binding activity at the proteome scale will greatly enhance our understanding of various biological processes. Here we report a highly sensitive, rapid, and high-throughput approach, transcription factor response elements on tip-mass spectrometry (TOT-MS), that allows for quantitative measurement of endogenous TFs. A total of 150 TFs from 1 μg of nuclear extracts can be quantified with single shot mass spectrometry detection in 1 h of machine time...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28191279/ros-dependent-activation-of-autophagy-through-the-pi3k-akt-mtor-pathway-is-induced-by-hydroxysafflor-yellow-a-sonodynamic-therapy-in-thp-1-macrophages
#5
Yueqing Jiang, Jiayuan Kou, Xiaobo Han, Xuesong Li, Zhaoyu Zhong, Zhongni Liu, Yinghong Zheng, Ye Tian, Liming Yang
Monocyte-derived macrophages participate in infaust inflammatory responses by secreting various types of proinflammatory factors, resulting in further inflammatory reactions in atherosclerotic plaques. Autophagy plays an important role in inhibiting inflammation; thus, increasing autophagy may be a therapeutic strategy for atherosclerosis. In the present study, hydroxysafflor yellow A-mediated sonodynamic therapy was used to induce autophagy and inhibit inflammation in THP-1 macrophages. Following hydroxysafflor yellow A-mediated sonodynamic therapy, autophagy was induced as shown by the conversion of LC3-II/LC3-I, increased expression of beclin 1, degradation of p62, and the formation of autophagic vacuoles...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28187463/preoperative-albumin-to-globulin-ratio-predicts-survival-in-clear-cell-renal-cell-carcinoma-patients
#6
Zhen Chen, Yingjie Shao, Hongwei Yao, Qianfeng Zhuang, Kun Wang, Zhaoyu Xing, Xianlin Xu, Xiaozhou He, Renfang Xu
In this retrospective analysis, we evaluated associations between albumin to globulin ratio (AGR), clinicopathological characteristics, and survival in 592 patients with localized or locally advanced clear cell renal cell carcinoma (CCRCC) prior to nephrectomy. We found that low AGR was associated with more aggressive tumor behavior; patients with low AGR had poorer overall survival (OS) and cancer-specific survival (CSS) in Kaplan-Meier survival analyses both before and after propensity score matching, which was used to compensate for differences in baseline clinicopathological characteristics...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28165487/insight-into-the-role-of-surface-wettability-in-electrocatalytic-hydrogen-evolution-reactions-using-light-sensitive-nanotubular-tio2-supported-pt-electrodes
#7
Chenhui Meng, Bing Wang, Ziyue Gao, Zhaoyue Liu, Qianqian Zhang, Jin Zhai
Surface wettability is of importance for electrochemical reactions. Herein, its role in electrochemical hydrogen evolution reactions is investigated using light-sensitive nanotubular TiO2 supported Pt as hydrogen evolution electrodes (HEEs). The HEEs are fabricated by photocatalytic deposition of Pt particles on TiO2 nanotubes followed by hydrophobization with vaporized octadecyltrimethoxysilane (OTS) molecules. The surface wettability of HEEs is subsequently regulated in situ from hydrophobicity to hydrophilicity by photocatalytic decomposition of OTS molecules using ultraviolet light...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28161319/biophysical-and-neural-basis-of-resting-state-functional-connectivity-evidence-from-non-human-primates
#8
REVIEW
Li Min Chen, Pai-Feng Yang, Feng Wang, Arabinda Mishra, Zhaoyue Shi, Ruiqi Wu, Tung-Lin Wu, George H Wilson, Zhaohua Ding, John C Gore
Functional MRI (fMRI) has evolved from simple observations of regional changes in MRI signals caused by cortical activity induced by a task or stimulus, to task-free acquisitions of images in a resting state. Such resting state signals contain low frequency fluctuations which may be correlated between voxels, and strongly correlated regions are deemed to reflect functional connectivity within synchronized circuits. Resting state functional connectivity (rsFC) measures have been widely adopted by the neuroscience community, and are being used and interpreted as indicators of intrinsic neural circuits and their functional states in a broad range of applications, both basic and clinical...
February 2, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28121417/adhesion-of-microdroplets-on-water-repellent-surfaces-toward-the-prevention-of-surface-fouling-and-pathogen-spreading-by-respiratory-droplets
#9
Jieke Jiang, Hengdi Zhang, Wenqing He, Tianzhong Li, Hualin Li, Peng Liu, Meijin Liu, Zhaoyue Wang, Zuankai Wang, Xi Yao
Biofouling caused by the adhesion of respiratory microdroplets generated in sneezing and coughing plays an important role in the spread of many infectious diseases. Although water-repellent surfaces are widely used for the long-term repellency of aqueous solutions, their repellency to pathogen-containing microdroplets is elusive. In this work, microdroplets from picoliter to nanoliter were successfully generated in a controlled manner to mimic the exhaled microdroplets in sneezing and coughing, which allowed us to evaluate the adhesion of microdroplets on both superhydrophobic and lubricant-infused "slippery" surfaces for the first time...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28110025/do-the-complications-increased-in-the-anterolateral-right-side-approach-to-treat-the-cervical-degenerative-disorders-a-retrospective-cohort-study
#10
Zhaoyu Ba, Fumin Pan, Xiaoming Liu, Jianguang Zhu, Desheng Wu
The dysphagia and recurrent laryngeal nerve (RLN) palsy are the most common complications of the patients who underwent anterior cervical surgery in the current literature. These morbidities have led to the study of the impact of sidedness in anterior cervical spine surgery. However, many reports documented the left-side was more effective and safe than right-side based on the anatomy. So the right-side approach is more challenging. We retrospectively study 503 patients with cervical degenerative diseases who underwent cervical spinal surgery using anterolateral right-side approach in our spine center from September 1999 to December 2012 and evaluate the efficient and safety of the anterolateral right-side approach to treat the cervical degenerative diseases...
January 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28102849/berberine-sonodynamic-therapy-induces-autophagy-and-lipid-unloading-in-macrophage
#11
Jiayuan Y Kou, Ying Li, Zhaoyu Y Zhong, Yueqing Q Jiang, Xuesong S Li, Xiaobo B Han, Zhongni N Liu, Ye Tian, Liming M Yang
Impaired autophagy in macrophages accompanies the progression of atherosclerosis and contributes to lipid loading in plaques and ineffective lipid degradation. Therefore, evoking autophagy and its associated cholesterol efflux may provide a therapeutic treatment for atherosclerosis. In the present study, berberine-mediated sonodynamic therapy (BBR-SDT) was used to induce autophagy and cholesterol efflux in THP-1 macrophages and derived foam cells. Following BBR-SDT, autophagy was increased in the macrophages, autophagy resistance in the foam cells was prevented, and cholesterol efflux was induced...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28098966/surface-optical-rectification-from-layered-mos2-crystal-by-thz-time-domain-surface-emission-spectroscopy
#12
Yuanyuan Huang, Lipeng Zhu, Qiyi Zhao, Yaohui Guo, Zhaoyu Ren, Jintao Bai, Xinlong Xu
Surface optical rectification was observed from the layered semiconductor molybdenum disulfide (MoS2) crystal via terahertz (THz) time-domain surface emission spectroscopy under linearly polarized femtosecond laser excitation. The radiated THz amplitude of MoS2 has a linear dependence on ever-increasing pump fluence and thus quadratic with the pump electric field, which discriminates from the surface Dember field induced THz radiation in InAs and the transient photocurrent-induced THz generation in graphite...
January 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28092595/command-filter-based-adaptive-neural-tracking-controller-design-for-uncertain-switched-nonlinear-output-constrained-systems
#13
Ben Niu, Yanjun Liu, Guangdeng Zong, Zhaoyu Han, Jun Fu
In this paper, a new adaptive approximation-based tracking controller design approach is developed for a class of uncertain nonlinear switched lower-triangular systems with an output constraint using neural networks (NNs). By introducing a novel barrier Lyapunov function (BLF), the constrained switched system is first transformed into a new system without any constraint, which means the control objectives of the both systems are equivalent. Then command filter technique is applied to solve the so-called "explosion of complexity" problem in traditional backstepping procedure, and radial basis function NNs are directly employed to model the unknown nonlinear functions...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28076855/microrna-126-reduces-blood-retina-barrier-breakdown-via-the-regulation-of-vcam-1-and-bcl2l11-in-ischemic-retinopathy
#14
Xia Bai, Junpeng Luo, Xiaofeng Zhang, Jingjing Han, Zhaoyue Wang, Jingcheng Miao, Yanyan Bai
To evaluate the role of microRNA-126 (miR-126) in maintaining the integrity of the blood-retina barrier (BRB), we established a mouse model of oxygen-induced retinopathy (OIR) and measured the retinal levels of miR-126 using recombinant plasmid pCMV-MIR or pCMV-MIR-126 intravitreal injections. We also detected VCAM-1 and BCL2L11 levels. Retinal vaso-obliteration, VCAM-1 localization on retinal endothelial cells, the blood-retina vascular permeability or albumin leakage in retinas, TUNEL histology, Evans blue assays, or Western blotting for detecting albumin or tight junction levels in the retina was performed...
January 12, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28018899/theoretical-investigation-of-mono-and-di-chloro-substitient-effects-on-the-insulation-and-greenhouse-properties-of-octafluorocyclobutane
#15
Lin Cheng, Zhaoyu Qin, Chaohai Zhang, Huixuan Shi, Kun Zhao, Xiaoyu Xie, Haibo Ma
Octafluorocyclobutane, c-C4F8, and its derivatives are regarded as promising replacements of insulation gaseous SF6, which are currently widely used in electric equipment but suffer greatly from its greenhouse effect. Based on the recent finding that the dielectric and thermodynamics properties of insulating gases are greatly dependent on the molecule's microscopic electronic and vibrational parameters, in this work, we use density functional theory (DFT) to study the molecular structures, electron affinities, and IR-active vibrational frequencies as well as thermodynamic properties for c-C4F8 and a series of mono-, di-substituted c-C4F8 compounds...
2016: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28005078/hypericin-mediated-sonodynamic-therapy-induces-autophagy-and-decreases-lipids-in-thp-1-macrophage-by-promoting-ros-dependent-nuclear-translocation-of-tfeb
#16
Xuesong Li, Xin Zhang, Longbin Zheng, Jiayuan Kou, Zhaoyu Zhong, Yueqing Jiang, Wei Wang, Zengxiang Dong, Zhongni Liu, Xiaobo Han, Jing Li, Ye Tian, Yajun Zhao, Liming Yang
Lipid catabolism disorder is the primary cause of atherosclerosis. Transcription factor EB (TFEB) prevents atherosclerosis by activating macrophage autophagy to promote lipid degradation. Hypericin-mediated sonodynamic therapy (HY-SDT) has been proved non-invasively inducing THP-1-derived macrophage apoptosis; however, it is unknown whether macrophage autophagy could be triggered by HY-SDT to influence cellular lipid catabolism via regulating TFEB. Here, we report that HY-SDT resulted in the time-dependent THP-1-derived macrophage autophagy activation through AMPK/AKT/mTOR pathway...
December 22, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/28003765/%C3%AE-elemene-treatment-of-glioblastoma-a-single-center-retrospective-study
#17
Chunxiao Ma, Wei Zhou, Zhaoyue Yan, Mingqi Qu, Xingyao Bu
Glioblastoma (GBM) is the most common primary malignancy in the central nervous system. In this study, we investigated the therapeutic effects of β-elemene (ELE) treatment in patients with newly diagnosed GBM who received concomitant chemoradiotherapy and adjuvant chemotherapy with temozolomide. Our results indicated that compared with control, patients who received ELE showed significantly longer median progression-free survival (PFS) (8 months vs 11 months; P<0.001) and overall survival (OS) (18 months vs 21 months; P<0...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27966549/angular-dependent-anisotropic-terahertz-response-of-vertically-aligned-multi-walled-carbon-nanotube-arrays-with-spatial-dispersion
#18
Yixuan Zhou, Yiwen E, Xinlong Xu, Weilong Li, Huan Wang, Lipeng Zhu, Jintao Bai, Zhaoyu Ren, Li Wang
Spatial dispersion effect of aligned carbon nanotubes (CNTs) in the terahertz (THz) region has significance for both theoretical and applied consideration due to the unique intrinsically anisotropic physical properties of CNTs. Herein, we report the angular dependent reflection of p-polarized THz wave from vertically aligned multi-walled CNT arrays in both experiment and theory. The spectra indicate that the reflection depends on the film thickness of vertically aligned CNTs, the incident angle, and the frequency...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27951708/dynamics-of-pickering-emulsions-in-the-presence-of-an-interfacial-reaction-a-simulation-study
#19
Shuangliang Zhao, Bicai Zhan, Yaofeng Hu, Zhaoyu Fan, Marc Pera-Titus, Honglai Liu
Pickering emulsions combining surface-active and catalytic properties offer a promising platform for conducting interfacial reactions between immiscible reagents. Despite the significant progress in the design of Pickering interfacial catalysts for a broad panel of reactions, the dynamics of Pickering emulsions under reaction conditions is still poorly understood. Herein, using benzene hydroxylation with aqueous H2O2 as a model system, we explored the dynamics of benzene/water Pickering emulsions during reaction by dissipative particle dynamics...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27930906/an-elegant-circuit-for-balancing-risk-and-reward
#20
Zhaoyu Li, Adam J Iliff, X Z Shawn Xu
Animals constantly encounter conflicting cues in natural environments. To survive and thrive, they must make appropriate behavioral decisions. In this issue, Ghosh et al. (2016) identified a neural circuit underlying multisensory threat-reward decision making using an elegant C. elegans model.
December 7, 2016: Neuron
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