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https://www.readbyqxmd.com/read/28548224/resveratrol-beneficially-affects-meat-quality-of-heat-stressed-broilers-which-is-associated-with-changes-in-muscle-antioxidant-status
#1
Cheng Zhang, Xiaohui Zhao, Li Wang, Lei Yang, Xingyong Chen, Zhaoyu Geng
This study was conducted to evaluate the effect of dietary resveratrol (Res) supplementation on serum parameters, meat quality and muscle antioxidant status of broilers under heat stress (HS). A total of 270 21-day-old male Cobb broilers were randomly assigned to three treatment groups with six replicates of 15 birds each. The three treatment groups were as follows: the control group, in which birds were reared at 22 ± 1°C, and the HS and HS + Res (400 mg/kg) groups, in which birds were reared at 33 ± 1°C for 10 h (08...
May 26, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28535417/ezrin-nf-kb-activation-regulates-epithelial-mesenchymal-transition-induced-by-egf-and-promotes-metastasis-of-colorectal-cancer
#2
Yingru Li, Zhaoyu Lin, Bin Chen, Shuang Chen, Zhipeng Jiang, Taicheng Zhou, Zehui Hou, Youyuan Wang
There is growing evidence that epithelial mesenchymal-transition (EMT) plays significant roles in terms of tumor metastasis. There are a lot of cytokines inducing EMT of tumor cells, EGF is one of the important cytokines.Ezrin is a connexin between the cytoskeleton and the cell membrane, which is closely related to the morphological movement and metastasis of tumor cells.EGF can activate Ezrin and affects cell motility. In recent years, many studies have shown that NF-kB acts as an important transcription factor, involving in the process of EMT...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28527107/an-immune-related-six-lncrna-signature-to-improve-prognosis-prediction-of-glioblastoma-multiforme
#3
Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, Siqi Bao, Liang Cheng, Jie Sun
Recent studies have demonstrated the utility and superiority of long non-coding RNAs (lncRNAs) as novel biomarkers for cancer diagnosis, prognosis, and therapy. In the present study, the prognostic value of lncRNAs in glioblastoma multiforme was systematically investigated by performing a genome-wide analysis of lncRNA expression profiles in 419 glioblastoma patients from The Cancer Genome Atlas (TCGA) project. Using survival analysis and Cox regression model, we identified a set of six lncRNAs (AC005013.5, UBE2R2-AS1, ENTPD1-AS1, RP11-89C21...
May 19, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28504079/a-novel-nonsense-nbeal2-gene-mutation-causing-severe-bleeding-in-a-patient-with-gray-platelet-syndrome
#4
Lijuan Cao, Jian Su, Jiaming Li, Ziqiang Yu, Xia Bai, Zhaoyue Wang, Lijun Xia, Changgeng Ruan
Gray platelet syndrome (GPS) is a rare, inherited bleeding disorder characterized by the defect of platelet α-granule. Up to date, these are only four studies identifying NBEAL2 gene correlated with GPS. In the current report, we present a Chinese GPS patient who had severe bleeding tendency, abnormalities of platelet functions, and absence of platelet α-granules. Genomic DNA sequencing for the patient identified a nonsense mutation (g.27713C>A) of NBEAL2 gene (g.NG_031914.1) resulting in a premature protein (p...
May 15, 2017: Platelets
https://www.readbyqxmd.com/read/28487655/gastrodin-inhibits-store-operated-ca-2-entry-and-alleviates-cardiac-hypertrophy
#5
Changbo Zheng, Chun-Yin Lo, Zhaoyue Meng, Zhichao Li, Mingkui Zhong, Peng Zhang, Jun Lu, Zhaoxiang Yang, Fuman Yan, Yunting Zhang, Yu Huang, Xiaoqiang Yao
Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety issues. In the present study, we examined protective effect of gastrodin against cardiac hypertrophy and explored the underlying mechanism. Phenylephrine and angiotensin II were used to induce cardiac hypertrophy in a mouse model and a cultured cardiomyocyte model...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28470945/mri-evaluation-of-renal-ischemia-reperfusion-injury-in-rabbit-model
#6
Liang Pan, Jie Chen, Wei Xing, Zhaoyu Xing, Jinggang Zhang, Yan Peng, Zhuoli Zhang
To evaluate the feasibility of susceptibility weighted imaging (SWI) as a tool to identify the changes in the renal outer medulla (OM) in a rabbit model of renal ischemia reperfusion injury (IRI). New Zealand rabbits were used in this study (control = 10 and IRI groups = 40). The rabbits in the IRI group were subjected to left renal artery clamping for 60 minutes. T2-weighted (T2WI) and SWI examinations were performed at 1 h, 12 h, 24 h and 48 h after reperfusion (each n = 10). After the examinations, nephrectomy was performed for histologic evaluation...
May 4, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28469975/screening-and-identification-of-the-tumor-associated-antigen-ck10-a-novel-potential-liver-cancer-marker
#7
Zhaoyu Zhu, Zheng Liu, Yuchun Liu, Chunyan Wang, Ruyu Li, Hui Liu, Baohua Gu, Guodong Li, Shoutao Zhang
Hepatocellular carcinoma (HCC) is a malignancy that is associated with high mortality rates in Asia. These tumors are highly invasive and their etiology is frequently unknown. Thus, most patients are diagnosed in the middle and late stages of the disease, and thus do not have sufficient time for therapy. Therefore, it is essential to study the early diagnosis and treatment of HCC; in this regard, the study of tumor-associated antigens has received much attention. Here, antigens from the human primary HCC cell line, QGY-7703, were used to immunize mice in order to prepare monoclonal antibodies...
May 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28461461/high-spatial-correspondence-at-a-columnar-level-between-activation-and-resting-state-fmri-signals-and-local-field-potentials
#8
Zhaoyue Shi, Ruiqi Wu, Pai-Feng Yang, Feng Wang, Tung-Lin Wu, Arabinda Mishra, Li Min Chen, John C Gore
Although blood oxygenation level-dependent (BOLD) fMRI has been widely used to map brain responses to external stimuli and to delineate functional circuits at rest, the extent to which BOLD signals correlate spatially with underlying neuronal activity, the spatial relationships between stimulus-evoked BOLD activations and local correlations of BOLD signals in a resting state, and whether these spatial relationships vary across functionally distinct cortical areas are not known. To address these critical questions, we directly compared the spatial extents of stimulated activations and the local profiles of intervoxel resting state correlations for both high-resolution BOLD at 9...
May 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28458345/hydrogen-rich-water-attenuates-renal-injury-and-fibrosis-by-regulation-transforming-growth-factor-%C3%AE-induced-sirt1
#9
Zhaoyu Xing, Wanma Pan, Jing Zhang, Xianlin Xu, Xuemei Zhang, Xiaozhou He, Min Fan
The current research was designed to study the role of hydrogen in renal fibrosis and the renal epithelial to mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1). Hydrogen rich water (HW) was used to treat animal and cell models. Unilateral ureteral obstruction (UUO) was performed on Balb/c mice to create a model of renal fibrosis. Human kidney proximal tubular epithelial cells (HK-2 cells) were treated with TGF-β1 for 36 h to induce EMT. Serum creatinine (Scr) and blood urea nitrogen (BUN) were measured to test renal function, in addition, kidney histology and immunohistochemical staining of alpha-smooth muscle actin (α-SMA) positive cells was performed to examine the morphological changes...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28431216/synthesis-and-loading-dependent-characteristics-of-nitrogen-doped-graphene-foam-carbon-nanotube-manganese-oxide-ternary-composite-electrodes-for-high-performance-supercapacitors
#10
Tao Cheng, Baozhi Yu, Linli Cao, Huiyun Tan, Xinghua Li, Xinliang Zheng, Weilong Li, Zhaoyu Ren, Jinbo Bai
The ternary composite electrodes, nitrogen-doped graphene foam/carbon nanotube/manganese dioxide (NGF/CNT/MnO2), have been successfully fabricated via chemical vapor deposition (CVD) and facile hydrothermal method. The morphologies of the MnO2 nanoflakes presented the loading-dependent characteristics and the nanoflake thickness could also be tuned by MnO2 mass loading in the fabrication process. The correlation between their morphology and electrochemical performance was systematically investigated by controlling MnO2 mass loading in the ternary composite electrodes...
April 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28428063/percutaneous-endoscopical-transforaminal-approach-versus-plf-to-treat-the-single-level-adjacent-segment-disease-after-plf-plif-1-2-years-follow-up
#11
Zhaoyu Ba, Fumin Pan, Zhonghan Liu, Bin Yu, Laurel Fuentes, Desheng Wu, Jianguang Zhu
BACKGROUND: Adjacent segment disease (ASD) is a common complication after lumbar decompression and fusion surgery. Traditional revision-surgery, including posterior lumbar decompression and posterolateral fusion (PLF) or interbody fusion (PLIF) is traumatic. The percutaneous endoscopic transforaminal procedure (PE-TF) has been widely used in patients with lumbar disc disease. However, there are no reports about using PE-TF procedure to treat ASD in the current literature. OBJECTIVE: To compare the clinical outcomes between PE-TF and PLF for single-level ASD after PLF or PLIF...
April 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28377587/overexpression-of-gsn-could-decrease-inflammation-and-apoptosis-in-eae-and-may-enhance-vitamin-d-therapy-on-eae-ms
#12
Jifang Gao, Zhaoyu Qin, Xinyuan Guan, Juanjuan Guo, Huaqing Wang, Shilian Liu
The decrease of gelsolin (GSN) in the blood has been reported in multiple sclerosis (MS) patients and experimental allergic encephalomyelitis (EAE) animals, but the protective effect of GSN on EAE/MS lacks of evidence. In our study, we increased the GSN level in EAE by injecting GSN-overexpress lentivirus (LV-GSN) into the lateral ventricle and caudal vein and found that GSN administration can delay the onset and decrease the severity of EAE. Vitamin D is proven to have a therapeutic effect on MS/EAE; however, we previously found that vitamin D caused a downregulation of GSN, which might limit vitamin D efficacy...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28375226/temporal-pulse-precisely-sculpted-millijoule-level-fiber-laser-injection-system-for-high-power-laser-driver
#13
Dangpeng Xu, Xiaocheng Tian, Dandan Zhou, Zhaoyu Zong, Mengqiu Fan, Rui Zhang, Na Zhu, Lianghua Xie, Hongxun Li, Jianjun Wang, Mingzhong Li, Xiaomin Zhang
A fiber laser injection system used as a seeder for a high-power laser facility of inertial confinement fusion was designed to meet stringent requirements. Herein, we demonstrate the fiber laser injection system, whose output single-pulse energy reaches the millijoule class. With two-stage amplitude modulators, the system produces a pulse with a higher pulse shaping capability. In addition, amplifying the pulse with large-mode-area fiber and single polarization, large-mode-area photonic crystal fiber (PCF) ensures a good beam quality output...
April 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28372743/online-single-particle-measurement-of-fireworks-pollution-during-chinese-new-year-in-nanning
#14
Jingyan Li, Tingting Xu, Xiaohui Lu, Hong Chen, Sergey A Nizkorodov, Jianmin Chen, Xin Yang, Zhaoyu Mo, Zhiming Chen, Huilin Liu, Jingying Mao, Guiyun Liang
Time-resolved single-particle measurements were conducted during Chinese New Year in Nanning, China. Firework displays resulted in a burst of SO2, coarse mode, and accumulation mode (100-500nm) particles. Through single particle mass spectrometry analysis, five different types of particles (fireworks-metal, ash, dust, organic carbon-sulfate (OC-sulfate), biomass burning) with different size distributions were identified as primary emissions from firework displays. The fireworks-related particles accounted for more than 70% of the total analyzed particles during severe firework detonations...
March 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28366776/involvement-of-akt-gsk3%C3%AE-creb-signaling-pathway-on-chronic-omethoate-induced-depressive-like-behavior-and-improvement-effects-of-combined-lithium-chloride-and-astaxanthin-treatment
#15
Jingwen Qiao, Lixia Rong, Zhaoyue Wang, Meizeng Zhang
Chronic organophosphorus pesticides (OP) exposure is associated with an increased risk of depression, and there is an urgent need to find an effective treatment for the depressive-like symptoms caused by OP. The main purpose of this study was to investigate whether combined lithium chloride (LiCl) and astaxanthin (AST) treatment would manifest synergetic antidepressant effects on mice with chronic OP exposure, and to determine the role of the Akt/GSK3β/CREB signaling pathway. Our results showed that chronic omethoate exposure significantly increased immobility time in behavioral tests and induced neuron damage in HE staining...
March 30, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28352261/analysis-of-evolutionary-processes-of-species-jump-in-waterfowl-parvovirus
#16
Wentao Fan, Zhaoyu Sun, Tongtong Shen, Danning Xu, Kehe Huang, Jiyong Zhou, Suquan Song, Liping Yan
Waterfowl parvoviruses are classified into goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) according to their antigenic features and host preferences. A novel duck parvovirus (NDPV), identified as a new variant of GPV, is currently infecting ducks, thus causing considerable economic loss. This study analyzed the molecular evolution and population dynamics of the emerging parvovirus capsid gene to investigate the evolutionary processes concerning the host shift of NDPV. Two important amino acids changes (Asn-489 and Asn-650) were identified in NDPV, which may be responsible for host shift of NDPV...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28350073/dna-methylation-mediated-caspase-8-downregulation-is-associated-with-anti-apoptotic-activity-and-human-malignant-glioma-grade
#17
Yueqiu Teng, Yu-Cui Dong, Zhaoyu Liu, Yan Zou, Hui Xie, Yu Zhao, Jun Su, Fenglin Cao, Hua Jin, Huan Ren
The methylation-mediated silencing of tumor suppressors, including key apoptosis-related genes plays an important role in the pathogenesis and therapeutic resistance in human cancer. In this study, we aimed to elucidate the role and mechanisms of resistance to apoptosis with caspase-8 gene downregulation in human malignant glioma. Reverse transcription-polymerase chain reaction (RT-PCR) and methylation-specific PCR (MSP) were used to examine caspase-8 expressoin at the mRNA level and gene methylation status in normal brain tissue, glioma tissue and cancer cell lines...
February 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28337710/high-efficient-n-butanol-production-by-co-culturing-clostridium-acetobutylicum-and-saccharomyces-cerevisiae-integrated-with-butyrate-fermentative-supernatant-addition
#18
Hongzhen Luo, Qingwei Zeng, Shuo Han, Zhaoyu Wang, Qing Dong, Yanhong Bi, Yuping Zhao
Butanol is not only an important chemical intermediate and solvent in pharmaceutical and cosmetics industries, but also considered as an advanced biofuel. Although species of the natural host Clostridium have been engineered, butanol titers in the anaerobe seem to be limited by its intolerance to butanol less than 13 g/L. Here we aimed to develop a technology for enhancing butanol production by a co-culture system with butyrate fermentative supernatant addition. First, when adding 4.0 g/L butyrate into the acetone-butanol-ethanol (ABE) fermentation broth with single-shot at 24 h, the "acid crash" phenomenon occurred and the ABE fermentation performance deteriorated...
April 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28330873/amp-activated-protein-kinase-%C3%AE-1-promotes-atherogenesis-by-increasing-monocyte-to-macrophage-differentiation
#19
Miao Zhang, Huaiping Zhu, Ye Ding, Zhaoyu Liu, Zhejun Cai, Ming-Hui Zou
Monocyte-to-macrophage differentiation, which can be initiated by physiological or atherogenic factors, is a pivotal process in atherogenesis, a disorder in which monocytes adhere to endothelial cells and subsequently migrate into the subendothelial spaces, where they differentiate into macrophages and macrophage-derived foam cells and cause atherosclerotic lesions. However, the monocyte-differentiation signaling pathways that are activated by atherogenic factors are poorly defined. Here we report that the AMP-activated protein kinase α1 (AMPKα1) in monocytes promotes atherosclerosis by increasing monocyte differentiation and survival...
May 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28325756/a-novel-role-for-myeloid-cell-specific-neuropilin-1-in-mitigating-sepsis
#20
Xiaoyan Dai, Imoh Okon, Zhaoyu Liu, Yue Wu, Huaiping Zhu, Ping Song, Ming-Hui Zou
Sepsis-typically caused by an uncontrolled and amplified host systemic inflammatory response to microbial infection-is a life-threatening complex clinical disorder and remains a major cause of infection-related deaths in the intensive care unit. Emerging evidence suggests that neuropilin 1 (Nrp1), an originally defined coreceptor for class 3 semaphorins and VEGF, plays important roles in the immune system; however, the function and regulation of macrophage Nrp1 in host immune defense against bacterial infection remain unknown...
March 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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