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https://www.readbyqxmd.com/read/29329775/recent-advances-and-strategies-in-process-and-strain-engineering-for-the-production-of-butyric-acid-by-microbial-fermentation
#1
REVIEW
Hongzhen Luo, Rongling Yang, Yuping Zhao, Zhaoyu Wang, Zheng Liu, Mengyu Huang, Qingwei Zeng
Butyric acid is an important platform chemical, which is widely used in the fields of food, pharmaceutical, energy, etc. Microbial fermentation as an alternative approach for butyric acid production is attracting great attention as it is an environmentally friendly bioprocessing. However, traditional fermentative butyric acid production is still not economically competitive compared to chemical synthesis route, due to the low titer, low productivity, and high production cost. Therefore, reduction of butyric acid production cost by utilization of alternative inexpensive feedstock, and improvement of butyric acid production and productivity has become an important target...
January 3, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29318707/effects-of-different-rearing-systems-on-growth-performance-carcass-traits-meat-quality-and-serum-biochemical-parameters-of-chaohu-ducks
#2
Cheng Zhang, Richard-Hermann Ah Kan Razafindrabe, Kaikai Chen, Xiaohui Zhao, Lei Yang, Li Wang, Xingyong Chen, Sihua Jin, Zhaoyu Geng
This study was conducted using a total of 360 22-day-old Chaohu ducks to evaluate the effect of rearing system on growth performance, carcass traits, meat quality and serum parameters of male and female Chaohu ducks. The birds were divided and raised in separate pens according to sex and rearing system, with three replicate pens of 30 male or 30 female ducks per pen for each rearing system. The rearing systems consisted of a floor rearing system (FRS) and a net rearing system (NRS). Results showed that ducks raised in NRS had better growth performance, whereas, ducks raised in FRS exhibited better carcass traits and meat color, and lower intramuscular fat...
January 9, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29316252/manganese-12-acetate-suppresses-the-migration-invasion-and-epithelial-mesenchymal-transition-by-inhibiting-wnt-%C3%AE-catenin-and-pi3k-akt-signaling-pathways-in-breast-cancer-cells
#3
Hongping Ju, Yongxia Li, Xiqian Xing, Xisong Miao, Yunping Feng, Yunhui Ren, Jing Qin, Dian Liu, Zihao Chen, Zhaoyu Yang
BACKGROUND: Breast cancer is the leading cause of cancer-related death in the world, and it is of great value to reveal the molecular mechanisms of breast cancer progression and develop new therapeutic targets. METHODS: Transwell assay is used to analyze the migration and invasion of breast cancer cells. Real-time PCR and western blotting assay are applied to detect the expression levels of epithelial-mesenchymal transition markers and the key members of Wnt/β-catenin and PI3K/AKT signaling pathways...
January 8, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29304762/a-novel-lncrna-focus-expression-signature-for-survival-prediction-in-endometrial-carcinoma
#4
Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, Siqi Bao, Jie Sun
BACKGROUND: Endometrial cancer (UCEC) is a complex malignant tumor characterized by both genetic level and clinical trial. Patients with UCEC exhibit the similar clinical features, however, they have distinct outcomes due to molecular heterogeneity. The aim of this study was to access the prognostic value of long non-coding RNAs (lncRNAs) in UCEC patients and to identify potential lncRNA signature for predicting patients' survival and improving patient-tailored treatment. METHODS: We performed a comprehensive genome-wide analysis of lncRNA expression profiles and clinical data in a large cohort of 301 UCEC patients...
January 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29277184/-study-on-effects-and-mechanisms-of-phytochemicals-in-vegetables-and-fruits-%C3%A2-in-preventing-and-treating-lung-cancer
#5
Tiantian Guo, Congmin Liu, Zhaoyu Gao, Yutong He
Whether in the world or China, lung cancer is a malignant tumor which is harmful to human health. There were studies showed that lung cancer is tightly related to the environment factors and life style. The epidemiology study found that eating more fruits and vegetables can prevent lung cancer. Vegetables and fruits are rich in phytochemicals such as isothiocyanates, indoles, flavonoids and so on. These phytochemicals reduce the risk of lung cancer by modulating antitumor-related pathways such as inhibition of cell proliferation, induction of apoptosis, and the like...
December 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29275263/no-inhibitory-constituents-as-potential-anti-neuroinflammatory-agents-for-ad-from-blumea-balsamifera
#6
Jun Ma, Quanhui Ren, Bangjian Dong, Zhaoyu Shi, Jie Zhang, Da-Qing Jin, Jing Xu, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo
Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29229991/bok-promotes-chemical-induced-hepatocarcinogenesis-in-mice
#7
Tatiana Rabachini, Yuniel Fernandez-Marrero, Matteo Montani, Giulio Loforese, Valentina Sladky, Zhaoyue He, Daniel Bachmann, Simone Wicki, Andreas Villunger, Deborah Stroka, Thomas Kaufmann
BCL-2-related ovarian killer (BOK) is a conserved and widely expressed BCL-2 family member with sequence homology to pro-apoptotic BAX and BAK, but with poorly understood pathophysiological function. Since several members of the BCL-2 family are critically involved in the regulation of hepatocellular apoptosis and carcinogenesis we aimed to establish whether loss of BOK affects diethylnitrosamine (DEN)-induced hepatocarcinogenesis in mice. Short-term exposure to DEN lead to upregulation of BOK mRNA and protein in the liver...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29223541/functional-role-of-lncrna-loc101927497-in-n-methyl-n-nitro-n-nitrosoguanidine-induced-malignantly-transformed-human-gastric-epithelial-cells
#8
Yuanwei Luo, Min Liang, Wenxiao Yao, Jifang Liu, Qiuling Niu, Jitao Chen, Zhaoyu Liu, Ming Li, Boyun Shi, Jinhui Pan, Lin Zhou, Xinke Zhou
AIMS: Evidence shows that aberrant expression of long non-coding RNA (lncRNA) is closely associated with tumor development and progression. However, the role of lncRNA in environmental carcinogen induced gastric tumorigenesis remains largely unknown. This study aimed at investigating the function role of lncRNA in N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induce malignantly transformed human gastric epithelial cells. MAIN METHODS: In this study, high-throughput sequencing and qRT-PCR assay revealed marked downregulation of lncRNA LOC101927497 in the malignant transformed gastric epithelial cells induced by MNNG (GES-1-T cells), gain-of-function and loss-of-function assays showed that LOC101927497 can suppress the proliferation and migration of GES-1-T cells in vitro...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29220985/tungsten-based-highly-selective-solar-absorber-using-simple-nanodisk-array
#9
Xu Han, Kebo He, Zhubing He, Zhaoyu Zhang
In this paper, we report the design, fabrication, and characterization of a tungsten-based metamaterial selective solar absorber (SSA) combining a metal-insulator-metal (MIM) structure and simple nanodisk array. The as-fabricated absorber absorbs strongly and selectively in the wavelength range of 0.5-1.75 μm with a characterized absorptance of more than 90%, which drops abruptly to less than 12.6% beyond 2.5 μm. In addition, this broadband and highly selective absorber is polarization-insensitive under incidence of normal plane waves...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29215718/involvement-of-smad3-pathway-in-atrial-fibrosis-induced-by-elevated-hydrostatic-pressure
#10
Wei Wei, Fang Rao, Fangzhou Liu, Yumei Xue, Chunyu Deng, Zhaoyu Wang, Jiening Zhu, Hui Yang, Xin Li, Mengzhen Zhang, Yongheng Fu, Wensi Zhu, Zhixin Shan, Shulin Wu
Hypertension is a main risk factor for atrial fibrillation, but the direct effects of hydrostatic pressure on the atrial fibrosis are still unknown. The present study investigated whether hydrostatic pressure is responsible for atrial fibrosis, and addressed a potential role of the Smad pathway in this pathology. Biochemical assays were used to study regulation and expression of fibrotic factors in spontaneously hypertensive rats (SHRs) and Wistar rats, and in cardiac fibroblasts (CFs) cultured under standard (0 mmHg) and elevated (20, 40 mmHg) hydrostatic pressure...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215141/highly-efficient-gating-of-electrically-actuated-nanochannels-for-pulsatile-drug-delivery-stemming-from-a-reversible-wettability-switch
#11
Qianqian Zhang, Jianxin Kang, Zhiqiang Xie, Xungang Diao, Zhaoyue Liu, Jin Zhai
Many ion channels in the cell membrane are believed to function as gates that control the water and ion flow through the transitions between an inherent hydrophobic state and a stimuli-induced hydration state. The construction of nanofluidic gating systems with high gating efficiency and reversibility is inspired by this hydrophobic gating behavior. A kind of electrically actuated nanochannel is developed by integrating a polypyrrole (PPy) micro/nanoporous film doped with perfluorooctanesulfonate ions onto an anodic aluminum oxide nanoporous membrane...
December 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29180379/selection-of-internal-references-for-qrt-pcr-assays-of-human-hepatocellular-carcinoma-cell-lines
#12
Yang Liu, Zhaoyu Qin, Lili Cai, Lili Zou, Jing Zhao, Fan Zhong
Selecting internal references is important for normalising the loading quantity of samples in quantitative reverse transcription polymerase chain reaction (qRT-PCR). In this study, a systematic evaluation of reference genes among nine hepatocellular carcinoma cell lines was conducted. After screening the microarray assay data of 10 HCC cell lines, 19 candidate reference genes were preselected and then evaluated by qRT-PCR, together with ACTB , GAPDH , HPRT1 and TUBB The expression evenness of these candidate genes was evaluated using RefFinder...
November 27, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29177359/copper-inter-nanoclusters-distance-modulated-chromism-of-self-assembly-induced-emission
#13
Lin Ai, Zhaoyu Liu, Ding Zhou, Jiale Liu, Haoyang Zou, Zhennan Wu, Yi Liu, Hao Zhang, Bai Yang
Metal nanoclusters (NCs) have attracted broad attention for their molecular-like electronic structures and unique emission properties, but the difficulty in controlling emission color greatly limits their application in illumination and display. In this work, we demonstrate the capability to control the self-assembly induced emission (SAIE) of Cu NCs by modulating the inter-NC distance in the self-assembly materials, which is capable of tuning the emission color from green to red. The inter-NC distance is mainly modulated by controlling the experimental variables during the NC self-assembly, such as the species of the solvents and ligands, duration of assembly, temperature, and so forth...
November 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/29164787/factors-related-to-duration-of-untreated-psychosis-of-first-episode-schizophrenia-spectrum-disorder
#14
Yong Qiu, Leijun Li, Zhaoyu Gan, Jihui Wang, Liangrong Zheng, Jiaoshi Zhao, Nianhong Guan, Qinling Wei
AIM: Duration of untreated psychosis (DUP) is associated with outcome and functioning. It is expected that scientists will find factors that modulate DUP, but thus far, research on this topic has shown inconsistent results. Furthermore, similar studies in China are insufficient. This study aims to explore social and clinical factors for DUP in South China and to learn the influence that family plays on DUP through their awareness of psychosis. METHODS: Participants included 216 patients with first episode schizophrenia spectrum disorder...
November 22, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29163681/the-prognostic-value-of-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-for-patients-with-lung-cancer
#15
Liqun Wang, Di Liang, Xiaoli Xu, Jing Jin, Shumei Li, Guo Tian, Zhaoyu Gao, Congmin Liu, Yutong He
As the leading cause of cancer-associated mortality globally among males in 2012, lung cancer is a disease of particular concern. Previously, the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) were revealed to be prognostic factors for various types of cancer, including lung cancer. In the present study, a retrospective review was conducted with patients who were diagnosed with lung cancer between January 1, 2000 and December 31, 2005 in the Fourth Hospital of Hebei Medical University...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29149671/silver-nanoparticles-stimulate-the-proliferation-of-sulfate-reducing-bacterium-desulfovibrio-vulgaris
#16
Zhaoyu Chen, Ji Lu, Shu-Hong Gao, Min Jin, Philip L Bond, Ping Yang, Zhiguo Yuan, Jianhua Guo
The intensive use of silver nanoparticles (AgNPs) in cosmetics and textiles causes their release into sewer networks of urban water systems. Although a few studies have investigated antimicrobial activities of nanoparticles against environmental bacteria, little is known about potential impacts of the released AgNPs on sulfate reducing bacteria in sewers. Here, we investigated the effect of AgNPs on Desulfovibrio vulgaris Hidenborough (D. vulgaris), a typical sulfate-reducing bacterium (SRB) in sewer systems...
November 8, 2017: Water Research
https://www.readbyqxmd.com/read/29128567/haploinsufficiency-of-hnrnp-u-changes-activity-pattern-and-metabolic-rhythms
#17
Beibei Lai, Jianghuan Zou, Zhaoyu Lin, Zhipeng Qu, Anying Song, Ying Xu, Xiang Gao
The neuropeptides arginine vasopressin (Avp) and vasoactive intestinal polypeptide (Vip) are critical for the communication and coupling of suprachiasmatic nucleus neurons, which organize daily rhythms of physiology and behavior in mammals. However, how these peptides are regulated remains uncharacterized. We found that heterogeneous nuclear ribonucleoprotein U (hnRNP U) is essential for the expression of Avp and Vip. Loss of one copy of the Hnrnpu gene resulted in fragmented locomotor activities and disrupted metabolic rhythms...
November 9, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29125601/tm9sf4-is-a-novel-factor-promoting-autophagic-flux-under-amino-acid-starvation
#18
Lei Sun, Zhaoyue Meng, Yifei Zhu, Jun Lu, Zhichao Li, Qiannan Zhao, Yu Huang, Liwen Jiang, Xiaoqiang Yao
Autophagy is a highly complicated process with participation of large numbers of autophagy-related proteins. Under nutrient starvation, autophagy promotes cell survival by breaking down nonessential cellular components for recycling use. However, due to its high complexity, molecular mechanism of autophagy is still not fully understood. In the present study, we report a novel autophagy-related protein TM9SF4, which plays a functional role in the induction phase of autophagic process. TM9SF4 proteins were abundantly expressed in the kidney, especially in renal proximal tubular epithelial cells...
November 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29120944/targeted-genotyping-identifies-susceptibility-locus-in-brain-derived-neurotrophic-factor-gene-for-chronic-postsurgical-pain
#19
Yuanyuan Tian, Xiaodong Liu, Mingzhong Jia, Hui Yu, Peter Lichtner, Yujian Shi, Zhaoyu Meng, Shanglong Kou, Idy H T Ho, Bo Jia, Benny C P Cheng, Carmen K M Lam, Sharon Tsang, Sunny H Wong, Jun Yu, Christopher H K Cheng, Tony Gin, William K K Wu, Zheyu Chen, Matthew T V Chan
BACKGROUND: The purpose of this study was to evaluate the association between single-nucleotide polymorphisms and chronic postsurgical pain. METHODS: Using GoldenGate genotyping assays, we genotyped 638 polymorphisms within 54 pain-related genes in 1,152 surgical patients who were enrolled in our Persistent Pain after Surgery Study. Patients were contacted by phone to determine whether they had chronic postsurgical pain at 12 months. Polymorphisms identified were validated in a matched cohort of 103 patients with chronic postsurgical pain and 103 patients who were pain free...
November 9, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29117550/microrna-regulation-of-nachr-expression-and-nicotine-dependent-behavior-in-c-%C3%A2-elegans
#20
Manish Rauthan, Jianke Gong, Jinzhi Liu, Zhaoyu Li, Seth A Wescott, Jianfeng Liu, X Z Shawn Xu
Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. However, how nicotine upregulates nAChRs is not well understood. Here, we identify a key role for microRNA in regulating nicotine-dependent behavior by modulating nAChR expression in C. elegans. We show that the nAChR gene acr-19 and alg-1, a key Argonaute-family member in the microRNA machinery, are specifically required for nicotine withdrawal response following chronic nicotine treatment...
November 7, 2017: Cell Reports
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