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Kanglai Li, Jiong Tao, Yuemei Li, Minhua Chen, Xiuhua Wu, Yingtao Liao, Xiaolan Lin, Zhaoyu Gan
Background: The aim of the study was to describe and compare the patterns of medication persistence among patients with unipolar depression (UD) or bipolar depression in a 5-year follow-up, and explore their impact on long-term outcome. Patients and methods: A total of 333 eligible patients with current major depressive episode were observed and followed up from the first index prescription for 5 years. Lack of persistence or treatment interruption was defined as a gap of at least 2 consecutive months without taking any medication...
2018: Patient Preference and Adherence
Zhichao Li, Zhaoyue Meng, Jun Lu, Francis M Chen, Wing-Tak Wong, Gary Tse, Changbo Zheng, Wendy Keung, Kennis Tse, Ronald A Li, Liwen Jiang, Xiaoqiang Yao
Human pluripotent stem cell-derived cardiomyocytes have potential applications in disease modeling and drug screening. Therefore, it is important to understand the mechanisms and signaling pathways underlying the survival and death of these cells. Endoplasmic reticulum (ER) stress is triggered by various cellular stresses that disturb protein folding in the ER. Cells cope with ER stress by activating the unfolded protein response (UPR), a homeostatic signaling network that orchestrates the recovery of ER function...
May 11, 2018: Journal of Molecular and Cellular Cardiology
Yutong He, Zhaoyu Gao, Tiantian Guo, Feng Qu, Di Liang, Daojuan Li, Jin Shi, Baoen Shan
BACKGROUND: The association between fine particulate matter (PM2.5 ) and lung cancer (LC) mortality in China is limited. The Beijing-Tianjin-Hebei region is infamous for serious air pollution. Seven of the top 10 cities with the worst air quality are located in Hebei Province. Thus, we explored the effect of 10 years of PM2.5 on the LC mortality rate in Hebei Province. METHODS: We quantified associations between LC mortality and PM2.5 and estimated the LC mortality burden attributed to PM2...
May 14, 2018: Thoracic Cancer
Mengjiao Chen, Yumeng Xi, Lin Zhang, Hanfang Zeng, Yeqing Li, Zhaoyu Han
Objective: The aim of the study was to investigate the effect of zinc-bearing palygorskite (Zn-Pal) on rumen fermentation by in vitro gas-production system. Methods: In trial, 90 incubators were evenly divided into five groups: control (0 % Zn-Pal), treatment Ⅰ (0.2 % Zn-Pal), treatment Ⅱ (0.4 % Zn-Pal), treatment Ⅲ (0.6 % Zn-Pal) and treatment Ⅳ (0.8 % Zn-Pal). The contents of zinc fortreatments were 0, 49, 98, 147, 196 mg/kg, respectively. The main chemical composition and microstructure of Zn-Pal was investigated by X-ray diffraction...
April 19, 2018: Asian-Australasian Journal of Animal Sciences
Weihong Guo, Lizhi Deng, Jiang Yu, Zhaoyu Chen, Yanghee Woo, Hao Liu, Tuanjie Li, Tian Lin, Hao Chen, Mingli Zhao, Liming Zhang, Guoxin Li, Yanfeng Hu
Drug resistance is the major challenge facing cancer chemotherapy and nanoscale delivery systems based on natural materials, such as sericin, are a promising means of overcoming drug resistance. Yet, no attempt of introducing synthetic poly(γ-benzyl-L-glutamate) (PBLG) onto sericin polypeptide to fabricate a facile biocompatible and biodegradable micelle has been tried. Here, we prepared a polypeptide-based amphiphilic polymer containing hydrophilic sericin polypeptide backbone and PBLG side chains via ring-opening polymerization (ROP) strategy...
November 2018: Drug Delivery
Zhaoyu Lin, Lijuan Sun, Shule Xie, Shanyi Zhang, Song Fan, Qunxing Li, Weixiong Chen, Guokai Pan, Weiwei Wang, Bin Weng, Zhang Zhang, Bodu Liu, Jinsong Li
Increasing evidence has shown that chemo-resistance is related to the process of epithelial-mesenchymal transition (EMT) and increased invasiveness by tongue squamous cell carcinoma (TSCC) cells. Long non-coding RNAs (lncRNAs) play pivotal roles in tumor metastasis and progression. However, the roles and mechanisms of lncRNAs in cisplatin-resistance-induced EMT and metastasis are not well understood. In this study, a chemotherapy-induced lncRNA 1 (CILA1) was discovered by using microarrays and was functionally identified as a regulator of chemo-sensitivity in TSCC cells...
April 5, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Kai Han, Zhaoyu Ma, Xinxin Dai, Jin Zhang, Heyou Han
Tumor targeted drug delivery in vivo remains a significant challenge in tumor therapy. In this article, we fabricated a steric shielding protected/tumor acidity-activated chimeric peptide for tumor targeted photodynamic therapy. This amphiphilic chimeric peptide could form spherical nanoparticles at neutrally physiological environment with the shielding of biotin molecule (tumor target ligand). When in tumor acidic microenvironment, acidity-sensitive dimethylmaleic amide was rapidly hydrolyzed, resulting in subsequent liberation of (Lys)8 and the recovery of intramolecular electrostatic interaction between (Lys)8 and (Glu)8 ...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Cheng Zhang, Kaikai Chen, Xiaohui Zhao, Zhaoyu Geng
BACKGROUND: Resveratrol has been shown to prevent high ambient temperature (HT)-induced spleen dysplasia, but the mechanisms of action are not clear. This study aims to examine the hypothesis that HT-induced spleen dysplasia may be associated with HT-induced oxidative stress and apoptosis, while resveratrol may activate Nrf2 signaling pathway and thus reduces oxidative stress and apoptosis. RESULTS: Results showed that HT caused spleen dysplasia in broilers, reflecting by the lower relative weight of spleen (P<0...
April 20, 2018: Journal of the Science of Food and Agriculture
Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li, Xiang Gao
The original article [1] mistakenly omitted a source of funding, and the authors would like to rectify this by acknowledging the additional support of the Natural Science Foundation in Jiangsu Province (BK20150687).
April 19, 2018: Stem Cell Research & Therapy
Qing Yang, Dong Meng, Zhaoyu Gu, Wei Li, Qiuju Chen, Yang Li, Hui Yuan, Jie Yu, Chunsheng Liu, Tianzhong Li
In S-RNase-mediated self-incompatibility (SI), S-RNase secreted from the style destroys the actin cytoskeleton of the self-pollen tubes, eventually halting its growth, but the mechanism remains unclear. In vitro biochemical assays revealed that S-RNase does not bind or sever filamentous actin (F-actin). In apple (Malus×domestica), we identified an actin-binding protein containing myosin, villin and GRAM, MdMVG, that physically interacts with S-RNase and directly binds and severs F-actin. Immunofluorescence assays and total internal reflection fluorescence microscopy (TIRFM) indicated that S-RNase inhibits the F-actin-severing activity of MdMVG in vitro...
April 18, 2018: Plant Journal: for Cell and Molecular Biology
Zhaoyue Wang, Mingyue Jiang, Xuena Guo, Zhaozheng Liu, Xiuping He
BACKGROUND: 2-phenylethanol (2-PE) is an important aromatic compound with a lovely rose-like scent. Saccharomyces cerevisiae is a desirable microbe for 2-PE production but its natural yield is not high, and one or two crucial genes' over-expression in S. cerevisiae did not improve 2-PE greatly. RESULTS: A new metabolic module was established here, in which, permease Gap1p for L-phenylalanine transportation, catalytic enzymes Aro8p, Aro10p and Adh2p in Ehrlich pathway respectively responsible for transamination, decarboxylation and reduction were assembled, besides, glutamate dehydrogenase Gdh2p was harbored for re-supplying another substrate 2-oxoglutarate, relieving product glutamate repression and regenerating cofactor NADH...
April 11, 2018: Microbial Cell Factories
Gao Yi, Min Liang, Ming Li, Xiangming Fang, Jifang Liu, Yuxiong Lai, Jitao Chen, Wenxia Yao, Xiao Feng, La Hu, Chunyi Lin, Xinke Zhou, Zhaoyu Liu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive lung disease characterized by a mixture of small airway disease and lung tissue parenchymal destruction. Abnormal inflammatory responses to cigarette smoking and other noxious particles are generally thought to be responsible for causing of COPD. Since airway inflammation is a key factor in COPD progress, it is crucial to unravel its underlying molecular mechanisms. Unbiased analysis of genome-wide gene expression profiles in lung small airway epithelial cells provides a powerful tool to investigate this...
April 3, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Panpan Li, Zhaoyu Jin, Lele Peng, Fei Zhao, Dan Xiao, Yong Jin, Guihua Yu
Nanostructured conductive polymer hydrogels (CPHs) have been extensively applied in energy storage owing to their advantageous features, such as excellent electrochemical activity and relatively high electrical conductivity, yet the fabrication of self-standing and flexible electrode-based CPHs is still hampered by their limited mechanical properties. Herein, macromolecularly interconnected 3D graphene/nanostructured CPH is synthesized via self-assembly of CPHs and graphene oxide macrostructures. The 3D hybrid hydrogel shows uniform interconnectivity and enhanced mechanical properties due to the strong macromolecular interaction between the CPHs and graphene, thus greatly reducing aggregation in the fiber-shaping process...
March 27, 2018: Advanced Materials
Zhaoyu Yang, Rong Fan, Peng Sun, Hanjin Cui, Weijun Peng, Jiekun Luo, Chunhu Zhang, Xingui Xiong, Wei Huang, Wei Liu
Background: Rhubarb is a traditional Chinese medicine for treating traumatic brain injury (TBI). Purpose: The purpose of this study is to elucidate the potential mechanism of rhubarb by suppressing extracellular signal-regulated kinase (ERK) to ameliorate brain edema. Materials and Methods: Sprague-Dawley rats were separated into four groups at random. One group received 3 g/kg rhubarb, and another group received 12 g/kg rhubarb, and the vehicle group and sham group were administered the same dose of saline solution...
January 2018: Pharmacognosy Magazine
Xiaoming Liu, Fumin Pan, Zhaoyu Ba, Shanjin Wang, Desheng Wu
BACKGROUND: Diabetes mellitus (DM) and low back pain which is mainly caused by degeneration of the intervertebral discs (IVDs) both are major public health problem worldwide. The present study was designed to investigate the association between type 2 diabetes mellitus (T2D) and severity of lumbar disc degeneration (LDD). METHODS: We retrospectively reviewed patients with low back pain visiting our spine clinic in 2014. Low back pain patients all have the lumbar MRI imaging and no previous treatment...
March 14, 2018: Journal of Orthopaedic Surgery and Research
Zhaoyue Sun, Tianyuan Zheng, Jia Xin, Xilai Zheng, Rongting Hu, Fazle Subhan, Haibing Shao
Lignocellulosic agricultural residues were utilized as denitrification carbon substrates to improve the purification capacity of unsaturated soil and alleviate nitrate pollution of groundwater. In this study, corncob and wheat straw were treated by calcium hydroxide to improve biodegradability and enhance denitrification potential. Calcium hydroxide treatment decreased the contents of lignin (i.e., from 16.7 wt% to 15.2 wt% in corncob and from 21.9 wt% to 20.6 wt% in wheat straw), increased potential biodegradable carbon by 4...
March 10, 2018: Journal of Environmental Management
Dongfang Li, Daojuan Li, Guohui Song, Di Liang, Chao Chen, Yachen Zhang, Zhaoyu Gao, Yutong He
Cixian is one of the high-risk areas for upper gastrointestinal cancer in China and the world. From 2005, comprehensive population-based screening for upper gastrointestinal cancers has been conducted in Cixian. The aim of this study was to investigate population-based cancer survival from 2003 to 2013 and to explore the effect of screening on upper gastrointestinal cancer survival in Cixian. Observed survival was estimated using the life table method. The expected survival from the general population was calculated using all-cause mortality data from the population of Cixian with the EdererII method...
March 13, 2018: Cancer Medicine
Kai Xu, Huan Liu, Zhaoyu Zhang, Xiangyang Zhu
Among the advances in upper extremity prostheses in the past decades, only a small portion of the results were obtained for partial hand prostheses, possibly due to the highly diverse partial hand presentations and limited space for component integration. In an attempt to address these challenges, this paper presents the design, construction, installation, and experimental characterization of a wrist-powered partial hand prosthesis developed in Shanghai Jiao Tong University (hereafter referred to as the JTP hand), customized for a specific amputee...
March 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Qiuju Chen, Dong Meng, Zhaoyu Gu, Wei Li, Hui Yuan, Xuwei Duan, Qing Yang, Yang Li, Tianzhong Li
It has been proved that the gametophytic self-incompatibility (GSI), mainly exists in Rosaceae and Solanaceae, is controlled by S genes, which are two tightly linked genes located at highly polymorphic S -locus: the S-RNase for pistil specificity and the F-box gene ( SFB/SLF ) for pollen specificity, respectively. However, the roles of those genes in SI of peach are still a subject of extensive debate. In our study, we selected 37 representative varieties according to the evolution route of peach and identified their S genotypes...
2018: Frontiers in Plant Science
Yuchi Wu, Lihong Yang, Lingli Li, Xiuqing Wu, Zhicong Zhong, Zhiren He, Hongyan Ma, Lixin Wang, Zhaoyu Lu, Cun Cai, Daixin Zhao, Xiangxin Meng, Airong Qi, Aicheng Yang, Guobin Su, Xinfeng Guo, Xusheng Liu, Chuan Zou, Qizhan Lin
BACKGROUND: Patients on maintenance hemodialysis (MHD) frequently complain of insomnia. Poor sleep quality impairs their quality of life and adversely affects long-term outcome. Previously we applied auricular acupressure therapy (AAT) for MHD patients with insomnia and yielded favorable results. AAT probably improves sleep quality by stimulating the vagus nerve and inhibiting sympathetic overactivity. However, the efficacy of AAT for insomnia in this population is still lacking. The proposed randomized controlled trial (RCT) will evaluate the efficacy and safety of AAT for improvement of sleep quality in MHD patients with insomnia...
March 7, 2018: Trials
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