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https://www.readbyqxmd.com/read/28930829/the-curative-effects-of-radiotherapy-based-therapies-for-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-a-meta-analysis
#1
Minghai Shao, Chi Zhang, Qin Qin, Zhaoyue Zhang, Hongcheng Zhu, Xiaoke Di, Xinchen Sun
AIM: This meta-analysis was designed to fully assess the curative effects of radiotherapy-based therapies for human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC). METHODS: English articles were retrieved through searching Cochrane library, PubMed, and Embase databases updated to February 2017. Studies were selected based on the inclusion and exclusion criteria. The curative effects of radiotherapy-based therapies forHER2+ BC patients were assessed using hazard rates (HRs) or odds ratios (ORs), as well as their 95% confidence intervals (CIs)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28929150/developing-an-efficient-nico2s4-cocatalyst-for-improving-the-visible-light-h2-evolution-performance-of-cds-nanoparticles
#2
Junwen Peng, Junli Xu, Zhaoyu Wang, Zhengxin Ding, Sibo Wang
Developing efficient alternatives to the widely used Pt cocatalyst in photocatalytic H2O splitting is of great importance in view of large-scale production of clear H2 energy. Herein, we report the facile synthesis of NiCo2S4 and its first use as a highly active and cost-affordable cocatalyst to boost visible light H2 generation with the CdS semiconductor. The synthesized NiCo2S4/CdS composite materials are fully characterized by various techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV-Vis diffusion reflectance spectroscopy (DRS), and N2 adsorption measurements...
September 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28914224/rapid-risk-assessment-report-for-schistosomiasis-epidemic-in-jianli-county-caused-by-the-sunk-oriental-star-cruise-ship
#3
Ziling Ni, Xiaodong Tan, Bei Liu, Zhaoyu Ying, Xudong Gao, Fen Yang
BACKGROUND: At 9:28 pm on June 1, 2015, the cruise ship "Oriental Star" sank into Yangtze River in Jianli County, with 422 people killed. When the accident occurred, the Chinese government took immediate action and dispatched more than 9000 rescuers. The risk for outbreak of schistosomiasis was increased because of the shipwreck. Obviously it is critical to carry out risk assessment as soon as possible. METHODS: By means of the Delphi method, the situation was analyzed so that the government could fathom the severity of the accident...
September 15, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28911221/chemical-basis-for-deuterium-labeling-of-fat-and-nadph
#4
Zhaoyue Zhang, Li Chen, Ling Liu, Xiaoyang Su, Joshua D Rabinowitz
Much understanding of metabolism is based on monitoring chemical reactions in cells with isotope tracers. For this purpose, 13C is well suited due to its stable incorporation into biomolecules and minimal kinetic isotope effect. For redox reactions, however, deuterium tracing can provide valuable additional information. To date, studies examining NADPH production with deuterated carbon sources have failed to account for roughly half of NADPH's redox active hydrogen. Here we show that the missing hydrogen is the result of enzyme-catalyzed H-D exchange between water and NADPH...
September 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28900860/modified-immunosuppressive-therapy-with-porcine-antilymphocyte-globulin-plus-delayed-cyclosporine-a-in-children-with-severe-aplastic-anemia
#5
Qingya Cui, Pingping Sha, Haifei Chen, Hongshi Shen, Longmei Qin, Zhengyang Li, Tianqin Wu, Zhaoyue Wang
Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less expensive and more effective than rabbit ATG, is widely used. We sought to evaluate the efficacy and safety profile of modified IST with p-ALG plus delayed CsA at day 21 in 50 SAA children. Eighteen SAA patients who progressed from nonsevere aplastic anemia (NSAA) were classified as SAA-II; the other 32 patients were classified as SAA-I...
September 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28886531/long-non-coding-rna-hottip-promotes-hypoxia-induced-epithelial-mesenchymal-transition-of-malignant-glioma-by-regulating-the-mir-101-zeb1-axis
#6
Shanyi Zhang, Weiwei Wang, Guoxin Liu, Shule Xie, Qunxing Li, Yingru Li, Zhaoyu Lin
Hypoxia is a universal characteristic of solid tumor and involving cancer metastasis via epithelial-mesenchymal transition (EMT). Long non-coding RNAs (lncRNAs) are known to regulate carcinogenesis and metastasis of various cancers. The aim of this study was to identify the function role of lncRNAs in the hypoxia-induced EMT of malignant glioma. We used U87 and U251 cell lines were treated under hypoxia to induce EMT, then lncRNA microarray analyse was performed between U87-hypoxia and parental cell line. The relative expression of lncRNA and HIF-1α were detected by qRT-PCR between glioma tissues without metastasis and that with metastasis...
September 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28882771/eccentric-technique-for-foraminoplasty-in-percutaneous-endoscopic-transforaminal-procedure-a-technical-note
#7
Zhaoyu Ba, Zhiqiang Li, Zhonghan Liu, Haoxi Li, Desheng Wu, Jianguang Zhu
OBJECTIVE: To describe a modified technique usied for foraminoplasty in percutaneous endoscopic transforaminal procedure. METHODS: 58 patients (20 males and 38 females, average age 52.5 years) underwent percutaneous endoscopic transforaminal procedure by using our modified technique. Under the guidance of C-arm fluoroscopy, a kirschner wire was inserted into targeted superior articular process. After expanding the soft tissues, a trepan with the largest diameter was located through the kirschner wire and the angle of trepan was flexible enough to adjust to different operative conditions...
September 4, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28865329/a-retrospective-clinicopathological-study-of-lung-adenocarcinoma-total-tumor-size-can-predict-subtypes-and-lymph-node-involvement
#8
Cheng Chen, Zhijun Chen, Hanbo Cao, Jinggang Yan, Zhaoyu Wang, Hanbo Le, Jingjing Weng, Yongkui Zhang
PURPOSE: To analyze the predictive ability of total tumor size in lung adenocarcinoma subtype and lymph node involvement. MATERIALS AND METHODS: 1018 patients, ≤3cm tumor, were enrolled. The maximum diameter and other variables of each tumor were measured. RESULTS: The optimal cut-off value for total tumor size in differentiating AIS and MIA from IAC was <1.15cm, in distinguishing lymph node involvement, it was 1.65cm. CONCLUSIONS: Total tumor size could be a reliable predictor of lung adenocarcinoma subtype and lymph node involvement irrespective of ground glass, part solid and solid characteristics...
August 30, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28842574/using-the-new-cellcollector-to-capture-circulating-tumor-cells-from-blood-in-different-groups-of-pulmonary-disease-a-cohort-study
#9
Yutong He, Jin Shi, Gaofeng Shi, Xiaoli Xu, Qingyi Liu, Congmin Liu, Zhaoyu Gao, Jiaoteng Bai, Baoen Shan
Circulating tumor cells (CTCs) are promising biomarkers for clinical application. Cancer screening with Low-Dose Computed Tomography (LDCT) and CTC detections in pulmonary nodule patients has never been reported. The aim of this study was to explore the effectiveness of the combined methods to screen lung cancer. Out of 8313 volunteers screened by LDCT, 32 ground-glass nodules (GGNs) patients and 19 healthy volunteers were randomly selected. Meanwhile, 15 lung cancer patients also enrolled. CellCollector, a new CTC capturing device, was applied for CTCs detection...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833604/smart-bioinspired-nanochannels-and-their-applications-in-energy-conversion-systems
#10
REVIEW
Ruirui Li, Xia Fan, Zhaoyue Liu, Jin Zhai
Smart bioinspired nanochannels exhibiting ion-transport properties similar to biological ion channels have attracted extensive attention. Like ion channels in nature, smart bioinspired nanochannels can respond to various stimuli, which lays a solid foundation for mass transport and energy conversion. Fundamental research into smart bioinspired nanochannels not only furthers understanding of life processes in living bodies, but also inspires researchers to construct smart nanodevices to meet the increasing demand for the use of renewable resources...
August 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28827412/macrophage-liver-kinase-b1-inhibits-foam-cell-formation-and-atherosclerosis
#11
Zhaoyu Liu, Huaiping Zhu, Xaoyan Dai, Cheng Wang, Ye Ding, Ping Song, Ming-Hui Zou
Rationale: Liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppressor, which regulates the homeostasis of hematopoietic cells and immune responses. Macrophages transform into foam cells upon taking-in lipids. No role for LKB1 in foam cell formation has previously reported. Objective: We sought to establish the role of LKB1 in atherosclerotic foam cell formation. Methods and Results: LKB1 expression was examined in human carotid atherosclerotic plaques and in western diet fed atherosclerosis-prone Ldlr(-/-) and ApoE(-/-) mice...
August 21, 2017: Circulation Research
https://www.readbyqxmd.com/read/28791888/removal-of-organics-by-combined-process-of-coagulation-chlorination-ultrafiltration-optimization-of-overall-operation-parameters
#12
Gongduan Fan, Zhaoyue Su, Rujing Lin, Zhuwu Jiang, Renxing Xu, Shumin Wang
In order to gain the run parameters of the combined process of coagulation/in situ chlorination/ultrafiltration (UF) so that the system can remove as much organic contaminants as possible without serious membrane fouling, the impacts of operation conditions in coagulation and pre-chlorination unit on organics removal and membrane fouling rate were investigated in a pilot-scale test. The characteristics of organics in UF influent were examined by using the method of excitation emission matrix spectroscopy (EEMs) to find out fouling behavior of different natural organic matter (NOM) compositions to UF membrane...
August 9, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28780265/selective-enhancement-and-verification-of-woody-biomass-digestibility-as-a-denitrification-carbon-source
#13
Rongting Hu, Xilai Zheng, Jia Xin, Zhaoyue Sun, Tianyuan Zheng
The denitrification efficiency of woody biomass as carbon source is low because of its poor carbon availability. In this study, representative poplar sawdust was pretreated with lime and peracetic acid to enhance the biomass digestibility to different degrees; sawdust was then mixed with soil to investigate its denitrification efficiency. Under controllable conditions (25-95°C, 12-24h, varying dosages), sawdust digestibility (characterized by reducing sugar yield) was selectively enhanced 1.0-21.8 times over that of the raw sawdust (28...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28760324/the-role-of-plant-growth-promoting-bacteria-in-metal-phytoremediation
#14
Zhaoyu Kong, Bernard R Glick
Phytoremediation is a promising technology that uses plants and their associated microbes to clean up contaminants from the environment. In recent years, phytoremediation assisted by plant growth-promoting bacteria (PGPB) has been highly touted for cleaning up toxic metals from soil. PGPB include rhizospheric bacteria, endophytic bacteria and the bacteria that facilitate phytoremediation by other means. This review provides information about the traits and mechanisms possessed by PGPB that improve plant metal tolerance and growth, and illustrate mechanisms responsible for plant metal accumulation/translocation in plants...
2017: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/28741661/effect-of-dietary-resveratrol-supplementation-on-meat-quality-muscle-antioxidative-capacity-and-mitochondrial-biogenesis-of-broilers
#15
Cheng Zhang, Lei Yang, Xiaohui Zhao, Xingyong Chen, Li Wang, Zhaoyu Geng
BACKGROUND: The naturally occurring polyphenol resveratrol has been acknowledged with many beneficial biological effects. The aim of this study was to evaluate the influence of dietary resveratrol supplementation on meat quality, muscle antioxidative capacity and mitochondrial biogenesis of broilers. One hundred and eighty 21-d-old male Cobb broilers were randomly assigned to two groups and fed on a 0 mg kg(-1) or 400 mg kg(-1) resveratrol-supplemented diet for 21 d. Then, chickens were slaughtered and pectoralis major muscle (PM) samples were collected for analysis...
July 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28728543/integrative-analysis-of-the-pekin-duck-anas-anas-micrornaome-during-feather-follicle-development
#16
Xingyong Chen, Kai Ge, Min Wang, Cheng Zhang, Zhaoyu Geng
BACKGROUND: The quality and yield of duck feathers are very important economic traits that might be controlled by miRNA regulation. The aim of the present study was to investigate the mechanism underlying the crosstalk between individual miRNAs and the activity of signaling pathways that control the growth of duck feathers during different periods. We therefore conducted a comprehensive investigation using Solexa sequencing technology on the Pekin duck microRNAome over six stages of feather development at days 11, 15, and 20 of embryonic development (during the hatching period), and at 1 day and 4 and 10 weeks posthatch...
July 20, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28711804/effect-of-iron-iii-ion-on-moso-bamboo-pyrolysis-under-microwave-irradiation
#17
Qing Dong, Xiangqian Li, Zhaoyu Wang, Yanhong Bi, Rongling Yang, Jinfeng Zhang, Hongzhen Luo, Miaomiao Niu, Bo Qi, Chen Lu
The effect of iron(III) ion on microwave pyrolysis of moso bamboo was investigated. Hydrofluoric acid washing was used as a pilot process to demineralize moso bamboo in order to eliminate the influences of the other inorganics contained in moso bamboo itself. The results indicated that the addition of iron(III) ion increased the maximal reaction temperatures under microwave condition dependent on the amount of the added iron(III) ion. The production of the non-condensable gases was promoted by the addition of iron(III) ion mainly at the expense of liquid products...
July 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28659345/ablation-of-neuropilin-1-in-myeloid-cells-exacerbates-high-fat-diet-induced-insulin-resistance-through-nlrp3-inflammasome-in-vivo
#18
Xiaoyan Dai, Imoh Okon, Zhaoyu Liu, Tatiana Bedarida, Qilong Wang, Tharmarajan Ramprasath, Miao Zhang, Ping Song, Ming-Hui Zou
Neuropilin 1 (Nrp1), a coreceptor for class 3 semaphorins and growth factors, is highly expressed in vascular cells and myeloid cells, including macrophages. Unlike well-characterized proangiogenic functions of endothelial cell Nrp1, the contributions of macrophage Nrp1 within the context of metabolic dysfunction remain to be established. The aim of this study was to determine the contributions of macrophage Nrp1 in high-fat diet (HFD)-instigated insulin resistance in vivo. Insulin sensitivity and Nlrp3 inflammasome activation were monitored in wild-type (WT) and myeloid cell-specific Nrp1 knockout (Nrp1(myel-KO)) mice fed an HFD (60% kcal) for 16 weeks...
September 2017: Diabetes
https://www.readbyqxmd.com/read/28654297/eriodictyol-not-its-glucuronide-metabolites-attenuates-acetaminophen-induced-hepatotoxicity
#19
Zhaoyu Wang, Yao Lan, MingHao Chen, Cailing Wen, Yanxian Hu, Zhongqiu Liu, Ling Ye
Acetaminophen (APAP) is one of the most commonly used oral analgesics and antipyretics, but hepatotoxicity including liver failure may occur after overdose. The therapeutic options for treating APAP hepatotoxicity are limited. Eriodictyol, a dietary flavonoid with anti-inflammatory and antioxidant properties, was used here to determine its protective effects against APAP-induced hepatotoxicity in mice. Various administration routes and pharmacokinetics-pharmacodynamics (PK-PD) analyses were used to determine these effects...
July 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28646221/aberrant-activation-of-the-human-sex-determining-gene-in-early-embryonic-development-results-in-postnatal-growth-retardation-and-lethality-in-mice
#20
Tatsuo Kido, Zhaoyu Sun, Yun-Fai Chris Lau
Sexual dimorphisms are prevalent in development, physiology and diseases in humans. Currently, the contributions of the genes on the male-specific region of the Y chromosome (MSY) in these processes are uncertain. Using a transgene activation system, the human sex-determining gene hSRY is activated in the single-cell embryos of the mouse. Pups with hSRY activated (hSRY(ON)) are born of similar sizes as those of non-activated controls. However, they retard significantly in postnatal growth and development and all die of multi-organ failure before two weeks of age...
June 23, 2017: Scientific Reports
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