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https://www.readbyqxmd.com/read/28092595/command-filter-based-adaptive-neural-tracking-controller-design-for-uncertain-switched-nonlinear-output-constrained-systems
#1
Ben Niu, Yanjun Liu, Guangdeng Zong, Zhaoyu Han, Jun Fu
In this paper, a new adaptive approximation-based tracking controller design approach is developed for a class of uncertain nonlinear switched lower-triangular systems with an output constraint using neural networks (NNs). By introducing a novel barrier Lyapunov function (BLF), the constrained switched system is first transformed into a new system without any constraint, which means the control objectives of the both systems are equivalent. Then command filter technique is applied to solve the so-called "explosion of complexity" problem in traditional backstepping procedure, and radial basis function NNs are directly employed to model the unknown nonlinear functions...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28076855/microrna-126-reduces-blood-retina-barrier-breakdown-via-the-regulation-of-vcam-1-and-bcl2l11-in-ischemic-retinopathy
#2
Xia Bai, Junpeng Luo, Xiaofeng Zhang, Jingjing Han, Zhaoyue Wang, Jingcheng Miao, Yanyan Bai
To evaluate the role of microRNA-126 (miR-126) in maintaining the integrity of the blood-retina barrier (BRB), we established a mouse model of oxygen-induced retinopathy (OIR) and measured the retinal levels of miR-126 using recombinant plasmid pCMV-MIR or pCMV-MIR-126 intravitreal injections. We also detected VCAM-1 and BCL2L11 levels. Retinal vaso-obliteration, VCAM-1 localization on retinal endothelial cells, the blood-retina vascular permeability or albumin leakage in retinas, TUNEL histology, Evans blue assays, or Western blotting for detecting albumin or tight junction levels in the retina was performed...
January 12, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28018899/theoretical-investigation-of-mono-and-di-chloro-substitient-effects-on-the-insulation-and-greenhouse-properties-of-octafluorocyclobutane
#3
Lin Cheng, Zhaoyu Qin, Chaohai Zhang, Huixuan Shi, Kun Zhao, Xiaoyu Xie, Haibo Ma
Octafluorocyclobutane, c-C4F8, and its derivatives are regarded as promising replacements of insulation gaseous SF6, which are currently widely used in electric equipment but suffer greatly from its greenhouse effect. Based on the recent finding that the dielectric and thermodynamics properties of insulating gases are greatly dependent on the molecule's microscopic electronic and vibrational parameters, in this work, we use density functional theory (DFT) to study the molecular structures, electron affinities, and IR-active vibrational frequencies as well as thermodynamic properties for c-C4F8 and a series of mono-, di-substituted c-C4F8 compounds...
2016: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28005078/hypericin-mediated-sonodynamic-therapy-induces-autophagy-and-decreases-lipids-in-thp-1-macrophage-by-promoting-ros-dependent-nuclear-translocation-of-tfeb
#4
Xuesong Li, Xin Zhang, Longbin Zheng, Jiayuan Kou, Zhaoyu Zhong, Yueqing Jiang, Wei Wang, Zengxiang Dong, Zhongni Liu, Xiaobo Han, Jing Li, Ye Tian, Yajun Zhao, Liming Yang
Lipid catabolism disorder is the primary cause of atherosclerosis. Transcription factor EB (TFEB) prevents atherosclerosis by activating macrophage autophagy to promote lipid degradation. Hypericin-mediated sonodynamic therapy (HY-SDT) has been proved non-invasively inducing THP-1-derived macrophage apoptosis; however, it is unknown whether macrophage autophagy could be triggered by HY-SDT to influence cellular lipid catabolism via regulating TFEB. Here, we report that HY-SDT resulted in the time-dependent THP-1-derived macrophage autophagy activation through AMPK/AKT/mTOR pathway...
December 22, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/28003765/%C3%AE-elemene-treatment-of-glioblastoma-a-single-center-retrospective-study
#5
Chunxiao Ma, Wei Zhou, Zhaoyue Yan, Mingqi Qu, Xingyao Bu
Glioblastoma (GBM) is the most common primary malignancy in the central nervous system. In this study, we investigated the therapeutic effects of β-elemene (ELE) treatment in patients with newly diagnosed GBM who received concomitant chemoradiotherapy and adjuvant chemotherapy with temozolomide. Our results indicated that compared with control, patients who received ELE showed significantly longer median progression-free survival (PFS) (8 months vs 11 months; P<0.001) and overall survival (OS) (18 months vs 21 months; P<0...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27966549/angular-dependent-anisotropic-terahertz-response-of-vertically-aligned-multi-walled-carbon-nanotube-arrays-with-spatial-dispersion
#6
Yixuan Zhou, Yiwen E, Xinlong Xu, Weilong Li, Huan Wang, Lipeng Zhu, Jintao Bai, Zhaoyu Ren, Li Wang
Spatial dispersion effect of aligned carbon nanotubes (CNTs) in the terahertz (THz) region has significance for both theoretical and applied consideration due to the unique intrinsically anisotropic physical properties of CNTs. Herein, we report the angular dependent reflection of p-polarized THz wave from vertically aligned multi-walled CNT arrays in both experiment and theory. The spectra indicate that the reflection depends on the film thickness of vertically aligned CNTs, the incident angle, and the frequency...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27951708/dynamics-of-pickering-emulsions-in-the-presence-of-an-interfacial-reaction-a-simulation-study
#7
Shuangliang Zhao, Bicai Zhan, Yaofeng Hu, Zhaoyu Fan, Marc Pera-Titus, Honglai Liu
Pickering emulsions combining surface-active and catalytic properties offer a promising platform for conducting interfacial reactions between immiscible reagents. Despite the significant progress in the design of Pickering interfacial catalysts for a broad panel of reactions, the dynamics of Pickering emulsions under reaction conditions is still poorly understood. Herein, using benzene hydroxylation with aqueous H2O2 as a model system, we explored the dynamics of benzene/water Pickering emulsions during reaction by dissipative particle dynamics...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27930906/an-elegant-circuit-for-balancing-risk-and-reward
#8
Zhaoyu Li, Adam J Iliff, X Z Shawn Xu
Animals constantly encounter conflicting cues in natural environments. To survive and thrive, they must make appropriate behavioral decisions. In this issue, Ghosh et al. (2016) identified a neural circuit underlying multisensory threat-reward decision making using an elegant C. elegans model.
December 7, 2016: Neuron
https://www.readbyqxmd.com/read/27908775/regulation-of-general-amino-acid-permeases-gap1p-gata-transcription-factors-gln3p-and-gat1p-on-2-phenylethanol-biosynthesis-via-ehrlich-pathway
#9
Xianrui Chen, Zhaoyue Wang, Xuena Guo, Sha Liu, Xiuping He
In Saccharomyces cerevisiae, when l-phenylalanine (l-Phe) is used as the sole nitrogen source, 2-phenylethanol (PE) is mainly synthesized via the Ehrlich pathway. General amino acid permease Gap1p is response of aromatic amino acids transportation, and GATA transcription factors Gln3p and Gat1p regulate the transcription of permease gene and catabolic enzyme genes for nitrogen sources and aromatic amino acids utilization. In this study, it was demonstrated that over-expressing GLN3 gene from industrial yeast strain MT2 or S...
January 20, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/27878254/restoration-of-the-tumor-suppressor-function-to-mutant-p53-by-ganoderma-lucidum-polysaccharides-in-colorectal-cancer-cells
#10
Dan Jiang, Lingyao Wang, Tong Zhao, Zhaoyu Zhang, Renxia Zhang, Jingji Jin, Yong Cai, Fei Wang
Ganoderma lucidum polysaccharides (GLPs), isolated from spores, mycelia and fruiting bodies of Ganoderma lucidum, have been suggested to possess anticancer activities in a large number of basic studies. A recent survey revealed that GLP-induced inhibition of cancer cell growth was dependent on the existence of functional p53. However, the actual role of p53-mediated tumor-suppressing pathways in facilitating the anticancer effect of GLPs is still unclear. In the present study, we investigated the interaction between GLPs and mutant p53 that exists in more than half of the known types of cancers...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27863111/an-electrocatalytic-hydrogen-evolving-hybrid-electrolyte-battery-with-electrochemical-and-photoelectrochemical-charging-from-water-oxidation
#11
Zhaoyu Jin, Panpan Li, Dan Xiao
Decoupled hydrogen and oxygen production have been successfully embedded into an aqueous dual-electrolyte (acid-base) battery for simultaneous energy storage and conversion. We adopt a three-electrode configuration involving an electrocatalytic hydrogen-evolving electrode as cathode, an alkaline battery-type or capacitor-type anode as shuttle, as well as a charging assisting electrode for electro-/photoelectrochemically catalyzing water oxidation. The conceptual battery not only synergistically outputs electricity and chemical fuels with tremendous specific energy and power densities, but also supports various approaches to be charged by pure or solar-assisted electricity...
November 8, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27858952/subintimal-angioplasty-for-lower-limb-arterial-chronic-total-occlusions
#12
REVIEW
ZhiHui Chang, JiaHe Zheng, ZhaoYu Liu
BACKGROUND: In recent years subintimal angioplasty (SIA) has become an established percutaneous procedure for the treatment of symptomatic lower limb arterial chronic total occlusions. However, the clinical benefits of this practice remain unclear. The aim of the review was to determine the effectiveness of SIA on clinical outcomes. This is an update of a review first published in 2013. OBJECTIVES: To assess the effectiveness of SIA versus other treatment for people with lower limb arterial chronic total occlusions, determined by the effects on clinical improvement, technical success rate, patency rate, limb salvage rate, and morbidity rates...
18, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27833950/hyperspectral-imaging-analysis-of-a-photonic-crystal-bead-array-for-multiplex-bioassays
#13
Xiangwei Zhao, Tengfei Ma, Zhaoyu Zeng, Shiya Zheng, Zhongze Gu
For multiplex bioassays, one effective strategy is to employ microfluidic chips based on an array of photonic crystal beads (PCBs) that are encoded by their characteristic reflection spectrum (CRS). In this paper, we report a hyperspectral imaging system and algorithms for the high throughput decoding of a PCB array and subsequent detection. The results showed that the decoding accuracy of up to ∼500 PCBs is 98.56% with an excellent ability to extract low-intensity fluorescence intensities. The results also demonstrated hyperspectral imaging techniques which can simultaneously obtain both spatial and spectral information as powerful tools in the analysis of multiplex bioassays or microfluidic chips...
November 11, 2016: Analyst
https://www.readbyqxmd.com/read/27822021/time-to-lack-of-persistence-with-pharmacological-treatment-among-patients-with-current-depressive-episodes-a-natural-study-with-1-year-follow-up
#14
Kanglai Li, Qinling Wei, Guanying Li, Xiangjun He, Yingtao Liao, Zhaoyu Gan
INTRODUCTION: Medication nonadherence remains a big challenge for depressive patients. This study aims to assess and compare the medication persistence between unipolar depression (UD) and bipolar depression (BD). METHODS: A total of 146 UD and 187 BD patients were recruited at their first index prescription. Time to lack of persistence with pharmacological treatment (defined as a gap of at least 60 days without taking any medication) was calculated, and clinical characteristics were collected...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27815445/neutrophil-necroptosis-is-triggered-by-ligation-of-adhesion-molecules-following-gm-csf-priming
#15
Xiaoliang Wang, Zhaoyue He, He Liu, Shida Yousefi, Hans-Uwe Simon
Apoptosis is the most common form of neutrophil death under both physiological and inflammatory conditions. However, forms of nonapoptotic neutrophil death have also been observed. In the current study, we report that human neutrophils undergo necroptosis after exposure to GM-CSF followed by the ligation of adhesion receptors such as CD44, CD11b, CD18, or CD15. Using a pharmacological approach, we demonstrate the presence of a receptor-interacting protein kinase-3 (RIPK3)-a mixed lineage kinase-like (MLKL) signaling pathway in neutrophils which, following these treatments, first activates p38 MAPK and PI3K, that finally leads to the production of high levels of reactive oxygen species (ROS)...
November 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27797486/palladium-triggered-chemical-rescue-of-intracellular-proteins-via-genetically-encoded-allene-caged-tyrosine
#16
Jie Wang, Siqi Zheng, Yanjun Liu, Zhaoyue Zhang, Zhi Lin, Jiaofeng Li, Gong Zhang, Xin Wang, Jie Li, Peng R Chen
Chemical de-caging has emerged as an attractive strategy for gain-of-function study of proteins via small-molecule reagents. The previously reported chemical de-caging reactions have been largely centered on liberating the side chain of lysine on a given protein. Herein, we developed an allene-based caging moiety and the corresponding palladium de-caging reagents for chemical rescue of tyrosine (Tyr) activity on intracellular proteins. This bioorthogonal de-caging pair has been successfully applied to unmask enzymatic Tyr sites (e...
November 23, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27770224/regulation-of-crucial-enzymes-and-transcription-factors-on-2-phenylethanol-biosynthesis-via-ehrlich-pathway-in-saccharomyces-cerevisiae
#17
Zhaoyue Wang, Xuejing Bai, Xuena Guo, Xiuping He
2-Phenylethanol (2-PE) is widely used in food, perfume and pharmaceutical industry, but lower production in microbes and less known regulatory mechanisms of 2-PE make further study necessary. In this study, crucial genes like ARO8 and ARO10 of Ehrlich pathway for 2-PE synthesis and key transcription factor ARO80 in Saccharomyces cerevisiae were re-regulated using constitutive promoter; in the meantime, the effect of nitrogen source in synthetic complete (SC) medium with L-phenylalanine (L-Phe) on Aro8/Aro9 and Aro10 was investigated...
October 21, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27768348/nematic-quantum-critical-fluctuations-in-bafe_-2-x-ni_-x-as_-2
#18
Zhaoyu Liu, Yanhong Gu, Wei Zhang, Dongliang Gong, Wenliang Zhang, Tao Xie, Xingye Lu, Xiaoyan Ma, Xiaotian Zhang, Rui Zhang, Jun Zhu, Cong Ren, Lei Shan, Xianggang Qiu, Pengcheng Dai, Yi-Feng Yang, Huiqian Luo, Shiliang Li
We have systematically studied the nematic fluctuations in the electron-doped iron-based superconductor BaFe_{2-x}Ni_{x}As_{2} by measuring the in-plane resistance change under uniaxial pressure. While the nematic quantum critical point can be identified through the measurements along the (110) direction, as studied previously, quantum and thermal critical fluctuations cannot be distinguished due to similar Curie-Weiss-like behaviors. Here we find that a sizable pressure-dependent resistivity along the (100) direction is present in all doping levels, which is against the simple picture of an Ising-type nematic model...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27760603/-establishment-of-a-clinical-prediction-model-of-solid-solitary-pulmonary-nodules
#19
Wei Yu, Bo Ye, Liyun Xu, Zhaoyu Wang, Hanbo Le, Shanjun Wang, Hanbo Cao, Zhenda Chai, Zhijun Chen, Qingquan Luo, Yongkui Zhang
BACKGROUND: The solitary pulmonary nodule (SPN) is a common and challenging clinical problem, especially solid SPN. The object of this study was to explore the predictive factors of SPN appearing as pure solid with malignance and to establish a clinical prediction model of solid SPNs. METHODS: We had a retrospective review of 317 solid SPNs (group A) having a final diagnosis in the department of thoracic surgery, Shanghai Chest Hospital from January 2015 to December 2015, and analyzed their clinical data and computed tomography (CT) images, including age, gender, smoking history, family history of cancer, previous cancer history, diameter of nodule, nodule location (upper lobe or non-upper lobe, left or right), clear border, smooth margin, lobulation, spiculation, vascular convergence, pleural retraction sign, air bronchogram sign, vocule sign, cavity and calcification...
October 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27744450/combination-of-hydroxyl-acetylated-curcumin-and-ultrasound-induces-macrophage-autophagy-with-anti-apoptotic-and-anti-lipid-aggregation-effects
#20
Longbin Zheng, Ying Li, Xuesong Li, Jiayuan Kou, Zhaoyu Zhong, Yueqing Jiang, Zhongni Liu, Ye Tian, Liming Yang
BACKGROUND/AIMS: Sonodynamic therapy (SDT) is considered a new approach for the treatment of atherosclerosis. We previously confirmed that hydroxyl acetylated curcumin (HAC) was a sonosensitizer. In this study, we investigated the mechanism of THP-1 macrophage apoptosis and autophagy induced by HAC mediated SDT (HAC-SDT). METHODS: Cell viability was measured using a CCK-8 assay. Laser scanning confocal microscopy was used to measure the levels of intracellular reactive oxygen species (ROS), sub-cellular HAC localization, BAX and cytochrome C translocation, LC3 expression, monodansylcadaverine staining and Dil-labeled oxidized low density lipoprotein (Dil-ox-LDL) uptake...
2016: Cellular Physiology and Biochemistry
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