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https://www.readbyqxmd.com/read/28933603/autophagy-enables-retromer-dependent-plasma-membrane-translocation-of-slc2a1-glut-to-enhance-glucose-uptake
#1
Srirupa Roy, Jayanta Debnath
Macroautophagy/autophagy is traditionally viewed as an intracellular catabolic pathway that recycles core metabolites during starvation or stress. Recently, we found that autophagy also functions in the control of glucose uptake from the extracellular environment by facilitating cell surface expression of the glucose transporter SLC2A1/GLUT1. In response to increased glycolytic demand or acute glucose starvation, autophagosome induction titrates the RabGAP protein TBC1D5 away from its inhibitory interaction with the retromer complex and into MAP1LC3(+) compartments...
September 21, 2017: Autophagy
https://www.readbyqxmd.com/read/28931587/maternal-choline-supplementation-modulates-placental-nutrient-transport-and-metabolism-in-late-gestation-of-mouse-pregnancy
#2
Sze Ting Cecilia Kwan, Julia H King, Jian Yan, Zhen Wang, Xinyin Jiang, Jason S Hutzler, Hallie R Klein, J Thomas Brenna, Mark S Roberson, Marie A Caudill
Background: Fetal growth is dependent on placental nutrient supply, which is influenced by placental perfusion and transporter abundance. Previous research indicates that adequate choline nutrition during pregnancy improves placental vascular development, supporting the hypothesis that choline may affect placental nutrient transport.Objective: The present study sought to determine the impact of maternal choline supplementation (MCS) on placental nutrient transporter abundance and nutrient metabolism during late gestation...
September 20, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28926527/genistein-suppresses-aerobic-glycolysis-and-induces-hepatocellular-carcinoma-cell-death
#3
Sainan Li, Jingjing Li, Weiqi Dai, Qinghui Zhang, Jiao Feng, Liwei Wu, Tong Liu, Qiang Yu, Shizan Xu, Wenwen Wang, Xiya Lu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Xiaoming Fan, Wenhui Mo, Ling Xu, Chuanyong Guo
BACKGROUND: Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1α) levels and glycolysis in tumour cells are associated with an increased risk of mortality, cancer progression, and resistance to therapy. However, the effect of genistein on HIF-1α and glycolysis in hepatocellular carcinoma (HCC) is still unclear. METHODS: Cell viability, apoptosis rate, lactate production, and glucose uptake were measured in HCC cell lines with genistein incubation...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28915636/role-of-glucose-metabolism-related-gene-glut1-in-the-occurrence-and-prognosis-of-colorectal-cancer
#4
Wenming Feng, Ge Cui, Cheng-Wu Tang, Xiao-Lan Zhang, Chuang Dai, Yong-Qiang Xu, Hui Gong, Tao Xue, Hui-Hui Guo, Ying Bao
Colorectal cancer (CRC) ranks the third most commonly diagnosed cancer in males and the second in females worldwide. However, the functional and causal SNPs for CRC remain to be mined. Glucose transporter 1 (GLUT1), a pivotal rate-limiting element in the transport of glucose in malignancy cells, has been identified to be associated with many cancers. Here, we aim to explore the role of GLUT1 in the occurrence and prognosis of colorectal cancer in a Chinese population. We found that GLUT1 expression levels in CRC tumor tissues were significantly higher than those in the corresponding adjacent normal tissues, and Cox multivariate analysis demonstrated that the GLUT1 expression was an independent prognostic factor for CRC (HR = 2...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903497/downregulation-of-tmem70-in-rat-liver-cells-after-hepatocarcinogen-treatment-related-to-the-warburg-effect-in-hepatocarcinogenesis-producing-gst-p-expressing-proliferative-lesions
#5
Sayaka Mizukami, Yousuke Watanabe, Kota Nakajima, Yasuko Hasegawa-Baba, Meilan Jin, Toshinori Yoshida, Makoto Shibutani
We previously observed downregulation of mitochondrial oxidative phosphorylation-related protein, TMEM70, which is suggestive of disrupted cellular senescence, in GST-P-expressing (+) proliferative lesions from early hepatocarcinogenesis stages in rats. The present study investigated the immunohistochemical relationship between TMEM70 downregulation and cellular metabolic changes in carcinogenic processes, as well as the onset of the liver cell respiratory changes after repeated hepatocarcinogen treatment in rats...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28900510/egln1-c-myc-induced-lymphoid-specific-helicase-inhibits-ferroptosis-through-lipid-metabolic-gene-expression-changes
#6
Yiqun Jiang, Chao Mao, Rui Yang, Bin Yan, Ying Shi, Xiaoli Liu, Weiwei Lai, Yating Liu, Xiang Wang, Desheng Xiao, Hu Zhou, Yan Cheng, Fenglei Yu, Ya Cao, Shuang Liu, Qin Yan, Yongguang Tao
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis by activating lipid metabolism-associated genes, including GLUT1, and ferroptosis related genes SCD1 and FADS2, in turn, involved in the Warburg effect. WDR76 targeted these genes expression in dependent manner of LSH and chromatin modification in DNA methylation and histone modification...
2017: Theranostics
https://www.readbyqxmd.com/read/28899927/mir-138-protects-cardiac-cells-against-hypoxia-through-modulation-of-glucose-metabolism-by-targeting-pyruvate-dehydrogenase-kinase-1-pdk1
#7
Hang Zhu, Hao Xue, Qin-Hua Jin, Jun Guo, Yun-Dai Chen
Dysfunction of cardiac cells under hypoxia has been identified as an essential event leading to myocytes functional failure. MicroRNAs (miRNAs) are importantly regulatory small-noncoding RNAs that negatively regulate gene expression through the direct binding of 3'UTR region of their target mRNAs (12). Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovascular system under pathological conditions (13-17). Pyruvate Dehydrogenase Kinase 1 (PDK1) is a kinase which phosphorylates Pyruvate Dehydrogenase to inactivate it, leading to elevated anaerobic glycolysis and decreased cellular respiration...
September 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28892790/yap1-tead1-glut1-axis-dictates-the-oncogenic-phenotypes-of-breast-cancer-cells-by-modulating-glycolysis
#8
Chunli Lin, Xiaofeng Xu
Altered energy metabolism is a universal property of most cancer cells. The Hippo signaling pathway and its principal downstream effector YAP1 are responsible for tissue homeostasis including organ size, cell proliferation, apoptosis, and differentiation. Dysregulation of the Hippo pathway leads to the activation of YAP1 and further culminates in the development of multiple human cancers. In this study, by loss-of-function assay, we demonstrated that YAP1 contributed to the glycolytic phenotype of breast cancer cells...
September 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28887543/the-oxidative-state-of-cysteine-thiol-144-regulates-the-sirt6-glucose-homeostat
#9
David Long, Hanzhi Wu, Allen W Tsang, Leslie B Poole, Barbara K Yoza, Xianfeng Wang, Vidula Vachharajani, Cristina M Furdui, Charles E McCall
Control of glucose homeostasis plays a critical role in health and lifespan and its dysregulation contributes to inflammation, cancer and aging. NAD + dependent Sirtuin 6 (SIRT6) is a glucose homeostasis regulator in animals and humans and its regulation at the molecular level is unknown. Here, we report that a cysteine thiol redox sensor contributes to the role of SIRT6 in controlling glucose homeostasis. Sulfenylation of SIRT6 occurs in THP1 cells and primary human promonocytes during inflammation and in splenocytes from mice with sepsis...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886081/orexin-a-affects-hepg2-human-hepatocellular-carcinoma-cells-glucose-metabolism-via-hif-1%C3%AE-dependent-and-independent-mechanism
#10
Xing Wan, Yuanyuan Liu, Yuyan Zhao, Xiaoqi Sun, Dongxiao Fan, Lei Guo
Orexins are hypothalamic neuropeptides that regulate feeding, reward, wakefulness and energy homeostasis. The present study sought to characterize the involvement of orexin A in glucose metabolism in HepG2 human hepatocellular carcinoma cells, and investigated the role of hypoxia-inducible factor-1α (HIF-1α) in the response. HepG2 cells were exposed to different concentrations of orexin A (10-9 to 10-7 M) in vitro, without or with the orexin receptor 1 (OX1R) inhibitor (SB334867), HIF-1α inhibitor (YC-1) or a combination of both inhibitors...
2017: PloS One
https://www.readbyqxmd.com/read/28884839/effects-of-glut1-gene-silencing-on-proliferation-differentiation-and-apoptosis-of-colorectal-cancer-cells-by-targeting-the-tgf-%C3%AE-pi3k-akt-mtor-signaling-pathway
#11
Xue-Liang Wu, Li-Kun Wang, Dong-Dong Yang, Ming Qu, Yong-Jiang Yang, Fei Guo, Lei Han, Jun Xue
This study aims to investigate the effects of glucose transport l (Glut1) gene on proliferation, differentiation and apoptosis of colorectal cancer (CRC) cells by regulating the TGF-β/PI3K-AKT-mTOR signaling pathway. Immunohistochemistry was conducted to detect the positive Glut1 expression. Normal human CRC epithelial cells (CCD-18Co) and CRC cell line HCT116 were grouped into the control, blank, negative control (NC), and shGlut1-1 groups. RT-qPCR and Western blotting were performed to detect the expressions of Glut1, TGF-β1, PI3K, AKT, PTEN, mTOR, Bcl-2 and Bax...
September 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28874504/proteome-analysis-of-hypoxic-glioblastoma-cells-reveals-sequential-metabolic-adaptation-nbsp-of-one-carbon-metabolic-pathways
#12
Kangling Zhang, Pei Xu, James L Sowers, Daniel F Machuca, Barsam Mirfattah, Jason Herring, Hui Tang, Yan Chen, Bing Tian, Allan R Brasier, Lawrence C Sowers
Rapidly proliferating tumors are exposed to a hypoxic microenvironment due to their density, high metabolic consumption, and interruptions in blood flow due to immature angiogenesis. Cellular responses to hypoxia promote highly malignant and metastatic behavior, as well as a chemotherapy-resistant state. In order to better understand the complex relationships between hypoxic adaptations and cancer progression, we studied the dynamic proteome responses of glioblastoma cells exposed to hypoxia via an innovative approach: quantification of newly synthesized proteins using heavy stable-isotope arginine labeling combined with accurate assessment of cell replication by quantification of the light/heavy arginine ratio of peptides in histone H4...
September 5, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28864019/glyburide-treatment-in-gestational-diabetes-is-associated-with-increased-placental-glucose-transporter-1-expression-and-higher-birth-weight
#13
Paula Díaz, Kris Genelyn Dimasuay, Lindsey Koele-Schmidt, Brian Jang, Linda A Barbour, Thomas Jansson, Theresa L Powell
Use of glyburide in gestational diabetes (GDM) has raised concerns about fetal and neonatal side effects, including increased birth weight. Placental nutrient transport is a key determinant of fetal growth, however the effect of glyburide on placental nutrient transporters is largely unknown. We hypothesized that glyburide treatment in GDM pregnancies is associated with increased expression of nutrient transporters in the syncytiotrophoblast plasma membranes. We collected placentas from GDM pregnancies who delivered at term and were treated with either diet modification (n = 15) or glyburide (n = 8)...
September 2017: Placenta
https://www.readbyqxmd.com/read/28859884/a-network-of-insulin-peptides-regulate-glucose-uptake-by-astrocytes-potential-new-druggable-targets-for-brain-hypometabolism
#14
REVIEW
A M Fernandez, E Hernandez, D Guerrero-Gomez, A Miranda-Vizuete, I Torres Aleman
Astrocytes are major players in brain glucose metabolism, supporting neuronal needs on demand through mechanisms that are not yet entirely clear. Understanding glucose metabolism in astrocytes is therefore of great consequence to unveil novel targets and develop new drugs to restore brain energy balance in pathology. Contrary to what has been held for many years, we now present evidence that insulin, in association with the related insulin-like growth factor I (IGF-I) modulates brain glucose metabolism through a concerted action on astrocytes...
August 30, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28854375/deletion-of-glut1-and-glut3-reveals-multiple-roles-for-glucose-metabolism-in-platelet-and-megakaryocyte-function
#15
Trevor P Fidler, Robert A Campbell, Trevor Funari, Nicholas Dunne, Enrique Balderas Angeles, Elizabeth A Middleton, Dipayan Chaudhuri, Andrew S Weyrch, E Dale Abel
No abstract text is available yet for this article.
August 29, 2017: Cell Reports
https://www.readbyqxmd.com/read/28854263/assessment-of-metabolic-and-mitochondrial-dynamics-in-cd4-and-cd8-t-cells-in-virologically-suppressed-hiv-positive-individuals-on-combination-antiretroviral-therapy
#16
Jesse J R Masson, Andrew J Murphy, Man K S Lee, Matias Ostrowski, Suzanne M Crowe, Clovis S Palmer
Metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated the impact of HIV infection on key processes that regulate glucose uptake and mitochondrial biogenesis in subpopulations of CD4+ and CD8+ T cells from 18 virologically-suppressed HIV-positive individuals on combination antiretroviral therapy (cART; median CD4+ cell count: 728 cells/μl) and 13 HIV seronegative controls. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) production were also analysed in total CD4+ and CD8+ T cells...
2017: PloS One
https://www.readbyqxmd.com/read/28852964/ppar-%C3%AE-and-akt-regulate-glut1-and-glut3-surface-localization-during-mycobacterium-tuberculosis-infection
#17
Shyamashree Dasgupta, Ramesh Chandra Rai
The success of Mycobacterium tuberculosis (Mtb) as a pathogen stems from its ability to manipulate the host macrophage towards increased lipid biogenesis and lipolysis inhibition. Inhibition of lipolysis requires augmented uptake of glucose into the host cell causing an upregulation of the glucose transporters GLUT1 and GLUT3 on the cell surface. Mechanism behind this upregulation of the GLUT proteins during Mtb infection is hitherto unknown and demands intensive investigation in order to understand the pathways linked with governing them...
August 29, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28846077/metabolic-cooperation-between-co-cultured-lung-cancer-cells-and-lung-fibroblasts
#18
Michael I Koukourakis, Dimitra Kalamida, Achilleas G Mitrakas, Maria Liousia, Stamatia Pouliliou, Efthimios Sivridis, Alexandra Giatromanolaki
Cooperation of cancer cells with stromal cells, such as cancer-associated fibroblasts (CAFs), has been revealed as a mechanism sustaining cancer cell survival and growth. In the current study, we focus on the metabolic interactions of MRC5 lung fibroblasts with lung cancer cells (A549 and H1299) using co-culture experiments and studying changes of the metabolic protein expression profile and of their growth and migration abilities. Using western blotting, confocal microscopy and RT-PCR, we observed that in co-cultures MRC5 respond by upregulating pyruvate dehydrogenase (PDH) and the monocarboxylate transporter MCT1...
August 28, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28837922/development-of-glut4-selective-antagonists-for-multiple-myeloma-therapy
#19
Changyong Wei, Richa Bajpai, Horrick Sharma, Monique Heitmeier, Atul D Jain, Shannon M Matulis, Ajay K Nooka, Rama K Mishra, Paul W Hruz, Gary E Schiltz, Mala Shanmugam
Cancer cells consume more glucose to fuel metabolic programs fundamental to sustaining their survival, growth and proliferation. Among the fourteen SLC2A family members, GLUTs 1 and 4 are high-affinity glucose transporters. GLUT4 (SLC2A4) is highly expressed in muscle and adipose tissue. Basally retained within the cell, GLUT4 traffics to the plasma membrane (PM) in response to insulin and exercise-stimulation. The plasma cell malignancy multiple myeloma (MM) exhibits increased constitutive expression of GLUT4 on the PM, co-opting use of GLUT4 for survival and proliferation...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28822459/oral-propylene-glycol-modifies-follicular-fluid-and-gene-expression-profiles-in-cumulus-oocyte-complexes-and-embryos-in-feed-restricted-heifers
#20
G Gamarra, C Ponsart, S Lacaze, F Nuttinck, A Cordova, P Mermillod, B Marquant-Le Guienne, D Monniaux, P Humblot, A A Ponter
Dietary supplementation with propylene glycol (PG) increases in vitro production of high-quality embryos in feed-restricted heifers. The aim of the present study was to evaluate the effects of PG in feed-restricted heifers on follicular fluid insulin and insulin-like growth factor (IGF) 1 concentrations, expression of IGF system genes in oocytes and cumulus cells and the expression of selected genes in blastocysts. Feed-restricted (R) heifers were drenched with water or PG during induced oestrous cycles (400mL of PG or water/drench, daily drenching at 1600 hours for the first 9 days of the oestrous cycle)...
August 21, 2017: Reproduction, Fertility, and Development
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