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https://www.readbyqxmd.com/read/27753183/tolerability-of-up-to-200%C3%A2-days-of-prophylaxis-with-valganciclovir-oral-solution-and-or-film-coated-tablets-in-pediatric-kidney-transplant-recipients-at-risk-of-cytomegalovirus-disease
#1
G Varela-Fascinetto, C Benchimol, R Reyes-Acevedo, M Genevray, D Bradley, J Ives, H T Silva
This multicenter, open-label study evaluated the tolerability of extended prophylaxis with valganciclovir in pediatric kidney transplant recipients at risk of CMV disease. Fifty-six patients aged 4 months to 16 years received once-daily valganciclovir oral solution and/or tablets, dosed by BSA and renal function, for up to 200 days. The most common AEs on treatment were upper respiratory tract infection (33.9%), urinary tract infection (33.9%), diarrhea (32.1%), leukopenia (25.0%), neutropenia (23.2%), and headache (21...
October 17, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27742343/bacterial-infections-after-kidney-transplantation-a-single-center-experience
#2
L Illesy, M Szabo-Pap, F Toth, G Zadori, L Zsom, L Asztalos, R P Szabo, R Fedor, B Nemes
BACKGROUND: Bacterial infections significantly affect graft loss and mortality after kidney transplantation (KT). We reviewed the frequencies, risk factors, and sources of bacterial infections after KT and their impact on graft and patient survivals. METHODS: The data of 154 kidney recipients who underwent transplantation from 2010 to 2015 were explored. Donor, recipient, and surgical parameters were collected, and source, type, and frequency of infectious complications, number of infective episodes, multidrug-resistant (MDR) bacteria, and the bacterial spectrum were established...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27725333/-the-use-of-ureteral-stents-and-catheters-in-renal-transplantation
#3
V Gómez-Dos Santos, V Díez-Nicolás, L Martínez-Arcos, J J Fabuel-Alcañiz, I Laso-García, S Álvarez-Rodríguez, F de Asís Donis-Canet, V Hevia-Palacios, M Ruiz-Hernández, F J Burgos-Revilla
: Mayor urological complications, fistulae and stenosis, mainly affect the vesicoureteral anastomosis and present in the early post-transplant period. The systematic use of ureteral catheters keeps selecbeing controversial with many groups using them only selectively depending on the existence of pretransplant or intraoperative risk factors. METHODS: We performed a bibliographic review through automatized search in the Medline bibliographic database, as the main bibliographic source, and also in Clinical Key...
October 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27704056/endoureteral-management-of-renal-graft-ureteral-stenosis-by-the-use-of-long-term-metal-stent-an-appealing-treatment-option
#4
Patrick-Julien Treacy, Art R Rastinehad, Laetitia Imbert de la Phalecque, Laetitia Albano, Matthieu Durand
Background: Ureteral stenosis is part of the common complications of renal graft reported in 3% to 7% of cases. Multiple treatments have been introduced regarding length and position of the stenosis. Metal stents for urologic purpose were created in 1998. Double percutaneous antegrade and transurethral retrograde access to a ureteral stenosis to a long-term metal stent procedure has been rarely described. Case Presentation: Here, we present a case of a ureteral stricture in a double ipsilateral kidney graft with a common ureter...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27693310/the-selective-biomarker-il-8-identifies-ifta-after-kidney-transplantation-in-blood-cells
#5
Mareen Matz, Christine Lorkowski, Katharina Fabritius, Kaiyin Wu, Birgit Rudolph, Stefan Frischbutter, Susanne Brakemeier, Jens Gaedeke, Hans-H Neumayer, Mir-Farzin Mashreghi, Klemens Budde
Cellular and antibody-mediated rejection processes and also interstitial fibrosis/tubular atrophy (IFTA) lead to allograft dysfunction and loss. The search for accurate, specific and non-invasive diagnostic tools is still ongoing and essential for successful treatment of renal transplanted patients. Molecular markers in blood cells and serum may serve as diagnostic tools but studies with high patient numbers and differential groups are rare. We validated the potential value of several markers on mRNA level in blood cells and serum protein level in 166 samples from kidney transplanted patients under standard immunosuppressive therapy (steroids±mycophenolic acid±calcineurin inhibitor) with stable graft function, urinary tract infection (UTI), IFTA, antibody-mediated rejection (ABMR), and T-cell-mediated rejection (TCMR) applying RT-PCR and ELISA...
November 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27663089/free-microrna-levels-in-plasma-distinguish-t-cell-mediated-rejection-from-stable-graft-function-after-kidney-transplantation
#6
Mareen Matz, Christine Lorkowski, Katharina Fabritius, Pawel Durek, Kaiyin Wu, Birgit Rudolph, Hans-H Neumayer, Mir-Farzin Mashreghi, Klemens Budde
The potential diagnostic value of circulating free miRNAs in plasma compared to miRNA expression in blood cells for rejection processes after kidney transplantation is largely unknown, but offers the potential for better and timely diagnosis of acute rejection. Free microRNA expression of specific blood cell markers was measured in 160 plasma samples from kidney transplant patients under standard immunosuppressive therapy (steroids±mycophenolic acid±calcineurin inhibitor) with stable graft function, urinary tract infection, interstitial fibrosis and tubular atrophy, antibody-mediated rejection (ABMR), Borderline (Banff3), tubulo-interstitial (Banff4-I) and vascular rejection (Banff4-II/III) applying RT-PCR...
November 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27569945/posttransplant-urinary-tract-infection-rates-and-graft-outcome-in-kidney-transplantation-for-end-stage-renal-disease-due-to-reflux-nephropathy-versus-chronic-glomerulonephritis
#7
E Kara, T Sakaci, E Ahbap, T Sahutoglu, Y Koc, T Basturk, M Sevinc, C Akgol, A O Kayalar, Z A Ucar, A Unsal, N Seyahi
BACKGROUND: The goal of this study was to evaluate posttransplant urinary tract infection (UTI) rates and graft outcome in kidney transplantation for end-stage renal disease (ESRD) due to vesicoureteral reflux (VUR)-related reflux nephropathy (RN) versus chronic glomerulonephritis (CGN). METHODS: A total of 62 patients with ESRD who underwent kidney transplantation for VUR-related RN (VUR-RN group, n = 31; mean ± standard deviation age, 34.1 ± 6.0 years; 58.1% female) or CGN (CGN group, n = 31; mean age, 34...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27569938/meta-analysis-on-the-safety-and-efficacy-of-the-reperfusion-use-of-a-single-high-dose-of-anti-t-lymphocyte-globulin-fresenius-in-kidney-transplantation
#8
X Du, W Wang, Z-J Sun, L L Su, X-D Zhang
BACKGROUND: The aim of this study was to evaluate the effects of a single high dose of the anti-T-lymphocyte globulin Fresenius (ATG-F), given before kidney transplantation, on the prevention of acute rejection response and infections and on the survival rate of the renal graft and patient. METHODS: Databases including PubMed, Embase, and the Cochrane Library were searched to identify randomized controlled trials relevant to studying the presurgical use of a single high dose of ATG-F...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27496451/urinary-tract-infections-in-kidney-transplant-recipients-hospitalized-at-a-transplantation-and-nephrology-ward-1-year-follow-up
#9
J Gozdowska, M Czerwińska, Ł Chabros, G Młynarczyk, A Kwiatkowski, A Chmura, M Durlik
INTRODUCTION: The aim of this study was to investigate risk factors for urinary tract infections (UTI), the causative organisms of UTI and also their management and treatment. In addition, we evaluated the effects of UTI on renal graft function. METHODS: This analysis included 107 kidney transplant recipients (64% women) with a diagnosis of UTIs confirmed by positive results on urine culture. Type of pathogens, sensitivity to drugs, risk factors for infection, incidence of urosepsis, hospitalization period, treatment methods, and recurrence rates were analyzed...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27495879/anuria-since-birth-does-it-impact-outcome-of-kidney-transplant-in-infants
#10
Shefali Vyas, Isabel Roberti
Kidney transplantation (txp) in infants has recently made much progress but provides a unique challenge in infants anuric since birth. Little data exists on outcome of renal txp recipients with anuria since birth. Retrospective chart review was done for outcome of 27 children with wt ≤15 kg and they were divided into two groups: Group A (N=21) with urine output and Group B (N=6) anuric since birth had their urological complications and long-term outcome compared. Median age at the time of txp 18 vs 23 months, mean wt 10...
August 6, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27433463/ongoing-higher-infection-rate-in-abo-incompatible-kidney-transplant-recipient-is-it-a-serious-problem-a-single-center-experience
#11
Byung Hyun Choi, Duck Jong Han
PURPOSE: Additional clinical experience and knowledge regarding the barrier to transplantation of ABO blood type incompatibility could reduce the higher rate of infectious complications in ABO-incompatible kidney transplantation. METHODS: A total of 79 ABO-incompatible kidney transplantation (ABOiKT) patients were compared with 260 ABO-compatible kidney transplantation (ABOcKT) patients for basic clinical characteristics, infectious complications, rejection episodes, and graft survival...
July 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27136101/favorable-outcomes-of-renal-transplant-in-children-with-abnormal-lower-urinary-tract
#12
Engin Melek, Esra Baskin, Kaan Gulleroglu, Umut Selda Bayrakci, Gokhan Moray, Mehmet Haberal
OBJECTIVES: Chronic kidney disease caused by lower urinary tract abnormalities is a significant complication in pediatric care. Although there are conflicting reports about clinical outcomes in the past, favorable outcomes have been reported in recent years. Despite this, many centers still refrain from performing renal transplant in these patients. Here, we compared clinical outcomes of renal transplant recipients with and without lower urinary tract abnormalities. MATERIALS AND METHODS: Our study included 71 renal transplant recipients who were divided into 3 groups: 17 patients with abnormal lower urinary tracts having vesicoureteral reflux (group 1), 7 patients with abnormal lower urinary tracts having bladder dysfunction (group 2), and 47 patients with anatomically and functionally normal lower urinary tracts (group 3)...
May 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27112976/urinary-tract-infection-in-kidney-transplant-recipients
#13
Natalia Chacón-Mora, Jerónimo Pachón Díaz, Elisa Cordero Matía
Infectious complications remain a major cause of morbidity and mortality among transplant recipients. Urinary tract infection (UTI) is the most common infectious complication in kidney transplant recipients with a reported incidence from 25% to 75%, varies widely likely due to differences in definition, diagnostic criteria, study design, and length of observation. We sought reviews the incidence and importance of urinary tract infection on graft survival, the microbiology with special emphasis on multidrug resistant microorganisms, the therapeutic management of UTI and the prophylaxis of recurrent UTI among solid organ transplant recipients, highlighting the need for prospective clinical trials to unify the clinical management in this population...
April 21, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27110022/post-transplantation-infections-in-bolivia
#14
S Arze, L Arze, C Abecia
Over 26 years, we found 46 infectious episodes in 350 kidney transplant recipients. Fifteen were urinary tract infections, recurrent in 4 patients. There were 8 cytomegalovirus infections, three of them fatal when intravenous (IV) ganciclovir was not available. Seven patients had a reactivation of tuberculosis (TB) in the pleura, cervical spine, lumbar spine, knee, ankle, skin and peritoneum, respectively, and were all resolved satisfactorily with conventional anti-TB therapy. Three patients transplanted before routine prophylaxis with the use of acyclovir developed an extensive herpes zoster infection in the 1st 6 months after transplantation, which was resolved with the use of oral acyclovir, and 1 had a disseminated herpes simplex infection resolved with the use of IV acyclovir...
March 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27088545/should-asymptomatic-bacteriuria-be-systematically-treated-in-kidney-transplant-recipients-results-from-a-randomized-controlled-trial
#15
Julia Origüen, Francisco López-Medrano, Mario Fernández-Ruiz, Natalia Polanco, Esther Gutiérrez, Elena González, Eva Mérida, Tamara Ruiz-Merlo, Alejandra Morales-Cartagena, María Asunción Pérez-Jacoiste Asín, Ana García-Reyne, Rafael San Juan, María Ángeles Orellana, Amado Andrés, José María Aguado
The indication of antimicrobial treatment for asymptomatic bacteriuria (AB) after kidney transplantation (KT) remains controversial. Between January 2011 and December 2013 112 KT recipients that developed ≥1 episode of AB beyond the second month post-transplantation were included in this open-label trial. Participants were randomized (1:1 ratio) to the treatment group (systematic antimicrobial therapy for all episodes of AB occurring up to 24 months post-transplantation [53 patients]) or control group (no antimicrobial therapy [59 patients])...
April 18, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/26901081/urinary-calprotectin-differentiates-between-prerenal-and-intrinsic-acute-renal-allograft-failure
#16
Felix S Seibert, Christian Rosenberger, Susanne Mathia, Robert Arndt, Wolfgang Arns, Huppertz Andrea, Nikolaos Pagonas, Frederic Bauer, Walter Zidek, Timm H Westhoff
BACKGROUND: Urinary calprotectin has recently been identified as a promising biomarker for the differentiation between prerenal and intrinsic acute kidney injury (AKI) in the nontransplant population. The present study investigates whether calprotectin is able to differentiate between these 2 entities in transplant recipients as well. METHODS: Urinary calprotectin was assessed by enzyme-linked immunosorbent assay in 328 subjects including 125 cases of intrinsic acute allograft failure, 27 prerenal graft failures, 118 patients with stable graft function, and 58 healthy controls...
February 19, 2016: Transplantation
https://www.readbyqxmd.com/read/26754038/febrile-urinary-tract-infection-after-pediatric-kidney-transplantation-a-multicenter-prospective-observational-study
#17
Friederike Weigel, Anja Lemke, Burkhard Tönshoff, Lars Pape, Henry Fehrenbach, Michael Henn, Bernd Hoppe, Therese Jungraithmayr, Martin Konrad, Guido Laube, Martin Pohl, Tomáš Seeman, Hagen Staude, Markus J Kemper, Ulrike John
BACKGROUND: Febrile urinary tract infections (fUTIs) are common after kidney transplantation (KTx); however, prospective data in a multicenter pediatric cohort are lacking. We designed a prospective registry to record data on fUTI before and after pediatric KTx. METHODS: Ninety-eight children (58 boys and 40 girls) ≤ 18 years from 14 mid-European centers received a kidney transplant and completed a 2-year follow-up. RESULTS: Posttransplant, 38...
June 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26713403/effect-of-twice-yearly-denosumab-on-prevention-of-bone-mineral-density-loss-in-de-novo-kidney-transplant-recipients-a-randomized-controlled-trial
#18
M Bonani, D Frey, J Brockmann, T Fehr, T F Mueller, L Saleh, A von Eckardstein, N Graf, R P Wüthrich
We conducted an open-label, prospective, randomized trial to assess the efficacy and safety of RANKL inhibition with denosumab to prevent the loss of bone mineral density (BMD) in the first year after kidney transplantation. Ninety kidney transplant recipients were randomized 1:1 2 weeks after surgery to receive denosumab (60 mg at baseline and 6 months) or no treatment. After 12 months, total lumbar spine areal BMD (aBMD) increased by 4.6% (95% confidence interval [CI] 3.3-5.9%) in 46 patients in the denosumab group and decreased by -0...
June 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/26657128/urinary-tract-infection-among-renal-transplant-recipients-in-yemen
#19
Adnan S Gondos, Khaled A Al-Moyed, Abdul Baki A Al-Robasi, Hassan A Al-Shamahy, Naelah A Alyousefi
Urinary tract infection (UTI) is the most common complication following kidney transplantation (KT), which could result in losing the graft. This study aims to identify the prevalence of bacterial UTI among KT recipients in Yemen and to determine the predisposing factors associated with post renal transplantation UTI. A cross sectional study included of 150 patients, who underwent KT was conducted between June 2010 and January 2011. A Morning mid-stream urine specimen was collected for culture and antibiotic susceptibility test from each recipient...
2015: PloS One
https://www.readbyqxmd.com/read/26629154/comparison-of-anti-reflux-mechanism-between-double-j-stent-and-standart-double-j-stent-use-for-risk-of-bk-nephropathy-and-urinary-tract-infection-in-kidney-transplantation
#20
Nurettin Ay, Mehmet Veysi Bahadır, Melih Anıl, Vahhac Alp, Şafak Kaya, Utkan Sevük, Mesut Gül, Ramazan Danış
OBJECTIVES: There are studies that show that double J stenting (DJS) increase BK nephropathy (BKN) 4 fold. DJS may cause vesicoureteral reflux (VUR) with normal bladder contraction. The aim of this study is to comparison risk of BKN, urinary tract infections (UTI) and postoperative urologic complications with the use DJS with anti-reflux device (ARD-DJS) and standart double J stent (St-DJS). Matherial and methods: Ninety patients (male/female: 50/40) that had undergone kidney transplantations in Diyarbakır Training and Research Hospital and Dicle University, Faculty of Medicine Hospital between January 2012 and April 2015 were enrolled in the study...
2015: International Journal of Clinical and Experimental Medicine
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