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Ibd and probiotics

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https://www.readbyqxmd.com/read/28733028/bifidobacterium-longum-affects-the-methylation-level-of-forkhead-box-p3-promoter-in-2-4-6-trinitrobenzenesulphonic-acid-induced-colitis-in-rats
#1
Ming Zhang, Lixing Zhou, Shu Zhang, Yang Yang, Lei Xu, Zichun Hua, Xiaoping Zou
Bifidobacterium longum (B. Longum) is a common probiotic colonized in the human gut and against the development of chronic inflammation including inflammatory bowel disease (IBD). But the underlying mechanism remains unknown. The aim of this study was to evaluate the affection of B. longum on the methylation levels of forkhead box P3 (Foxp3) promoter. 2, 4, 6-trinitrobenzenesulphonic acid (TNBS)-induced colitis rat models were treated with B. longum or medium, respectively. The genomic DNA of spleen peripheral blood mononuclear cells (PBMC) cells was extracted...
July 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28692320/the-probiotic-vsl-3-modulates-colonic-macrophages-inflammation-and-microflora-in-acute-trinitrobenzene-sulfonic-acid-colitis
#2
Raymond A Isidro, Abdon Lopez, Myrella L Cruz, Mayra I Gonzalez Torres, Gladys Chompre, Angel A Isidro, Caroline B Appleyard
The probiotic mixture VSL#3 attenuates colitis in patients with Inflammatory Bowel Disease (IBD) and in animal models of this condition, but the mechanisms involved are incompletely understood. VSL#3 alters macrophage morphology and secretory profile in vitro in a polarization-dependent manner. We examined the effect of VSL#3 on macrophages in acute trinitrobenzene sulfonic acid-induced colitis. Rats were randomized to normal, colitis, or colitis+VSL#3 groups. After sacrifice, the colons were evaluated for macroscopic and microscopic damage...
August 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28679372/fermented-herbal-formula-kiom-ma-128-protects-against-acute-colitis-induced-by-dextran-sodium-sulfate-in-mice
#3
Dong-Gun Kim, Mi-Ra Lee, Jae-Myung Yoo, Kwang-Il Park, Jin-Yeul Ma
BACKGROUND: Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from KIOM-MA using probiotics to improve the therapeutic efficacy. We investigated whether KIOM-MA-128 has protective activity in a mouse model of acute colitis induced by dextran sodium sulfate (DSS). METHODS: Colitis was induced by DSS administered to ICR mice in drinking water...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28678609/randomized-controlled-trial-evaluating-the-effect-of-multi-strain-probiotic-on-the-mucosal-microbiota-in-canine-idiopathic-inflammatory-bowel-disease
#4
Robin White, Todd Atherly, Blake Guard, Giacomo Rossi, Chong Wang, Curtis Mosher, Craig Webb, Steve Hill, Mark Ackermann, Peter Sciabarra, Karin Allenspach, Jan Suchodolski, Albert E Jergens
The intestinal microbiota is increasingly linked to the pathogenesis of idiopathic inflammatory bowel disease (IBD) in dogs. While studies have reported alterations in fecal (luminal) microbial populations, only limited information is available about the mucosal microbiota of IBD dogs at diagnosis and following medical therapy. Our aim was to characterize the mucosal microbiota and determine the clinical, microbiological, and mucosal homeostatic effects of probiotic treatment in dogs with IBD. Thirty four IBD dogs were randomized to receive standard therapy (ST = diet + prednisone) with or without probiotic...
July 5, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28653751/systematic-review-with-meta-analysis-the-efficacy-of-probiotics-in-inflammatory-bowel-disease
#5
REVIEW
Y Derwa, D J Gracie, P J Hamlin, A C Ford
BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are inflammatory bowel diseases (IBD). Evidence implicates disturbances of the gastrointestinal microbiota in their pathogenesis. AIM: To perform a systematic review and meta-analysis to examine the efficacy of probiotics in IBD. METHODS: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched (until November 2016). Eligible randomised controlled trials (RCTs) recruited adults with UC or CD, and compared probiotics with 5-aminosalicylates (5-ASAs) or placebo...
June 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28640662/using-probiotics-in-clinical-practice-where-are-we-now-a-review-of-existing-meta-analyses
#6
Mariangela Rondanelli, Milena Anna Faliva, Simone Perna, Attilio Giacosa, Gabriella Peroni, Anna Maria Castellazzi
The scientific literature has demonstrated that probiotics have a broad spectrum of activity, although often the results are contradictory. This study provides a critical overview of the current meta-analyses that have evaluated the efficacy of probiotics in physiologic and pathological conditions, such as metabolic disease, antibiotic-associated and Clostridium difficile-associated diarrhea, IBS, constipation, IBD, chemotherapy-associated diarrhea, respiratory tract infection, ventilator-associated pneumonia, NAFLD, liver encephalopathy, periodontitis, depression, vaginosis, urinary tract infections, pancreatitis, incidence of ventilator-associated pneumonia, hospital infection and stay in ICU, mortality of post-trauma patients, necrotising enterocolitis in premature infants...
June 22, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28631049/novel-probiotics-isolated-from-a-japanese-traditional-fermented-food-funazushi-attenuates-dss-induced-colitis-by-increasing-the-induction-of-high-integrin-%C3%AE-v-%C3%AE-8-expressing-dendritic-cells
#7
Yoshikiyo Okada, Yoshikazu Tsuzuki, Takajo Takeshi, Hirotaka Furuhashi, Masaaki Higashiyama, Chikako Watanabe, Kazuhiko Shirakabe, Chie Kurihara, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Ryota Hokari
BACKGROUND: We isolated two novel probiotics strains (s193 and s292) from Funazushi, which is a traditional Japanese fermented food, and evaluated its effects on DSS-induced colitis to determine the possible underlying mechanisms. METHODS: A single colony from homogenized Funazushi was isolated by its ability to suppress TNF-α in RAW 264.7. Effect of probiotics on colonic inflammation induced by DSS was evaluated. Effect of probiotics on Treg induction by CD11c(+) dendritic cells (DCs) of MLNs were analyzed...
June 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28618865/streptococcus-thermophilus-ncimb-41856-ameliorates-signs-of-colitis-in-an-animal-model-of-inflammatory-bowel-disease
#8
J R Bailey, V Vince, N A Williams, T A Cogan
Treatment of inflammatory bowel disease (IBD) is mainly based on suppression of symptoms, often with numerous side effects. Trials of probiotics in IBD have frequently produced disappointing results. The majority of probiotics are unusual, since they do not require iron for growth, unlike many bacteria resident in the intestine. The IBD intestine is iron-rich due to bleeding and use of oral iron supplements; conventional probiotics would be rapidly outcompeted. We have evaluated an iron-responsive Streptococcus thermophilus strain for its potential to reduce signs of colitis...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28555037/evidence-of-the-anti-inflammatory-effects-of-probiotics-and-synbiotics-in-intestinal-chronic-diseases
#9
REVIEW
Julio Plaza-Díaz, Francisco Javier Ruiz-Ojeda, Laura Maria Vilchez-Padial, Angel Gil
Probiotics and synbiotics are used to treat chronic diseases, principally due to their role in immune system modulation and the anti-inflammatory response. The present study reviewed the effects of probiotics and synbiotics on intestinal chronic diseases in in vitro, animal, and human studies, particularly in randomized clinical trials. The selected probiotics exhibit in vitro anti-inflammatory properties. Probiotic strains and cell-free supernatants reduced the expression of pro-inflammatory cytokines via action that is principally mediated by toll-like receptors...
May 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28552770/synbiotic-loaded-chitosan-ca-alginate-microparticles-reduces-inflammation-in-the-tnbs-model-of-rat-colitis
#10
Tanja Petreska Ivanovska, Kristina Mladenovska, Zoran Zhivikj, Maja Jurhar Pavlova, Ivica Gjurovski, Trpe Ristoski, Lidija Petrushevska-Tozi
New therapeutic strategies against inflammatory bowel disease (IBD) consider the usage of probiotics, prebiotics and synbiotics as beneficial for the intestinal microbial balance. Limitations of such an approach are addressed into difference in survival, persistence, colonization and variable effects among different probiotic strains, lack in understanding of probiotic mechanisms of action, as well the complex etiology of IBD. The anti-inflammatory activity of Lactobacillus casei 01 (L. casei 01) was assessed in trinitrobenzenesulphonic (TNBS) acid model of rat colitis when the probiotic was used alone and/or in combination with oligofructose-enriched inulin (Synergy 1), and as synbiotic (L...
May 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28502591/cd8-cd28-cd8-cd28-t-cell-equilibrium-can-predict-the-active-stage-for-patients-with-inflammatory-bowel-disease
#11
Shi-Xue Dai, Hong-Xiang Gu, Qian-Yi Lin, Shao-Zhuo Huang, Tiao-Si Xing, Qing-Fang Zhang, Gang Wu, Min-Hua Chen, Wan-Er Tan, Hong-Jian Jian, Zhong-Wen Zheng, Tao Zhong, Min-Hai Zhang, Xing-Fang Cheng, Peng Huang, Guang-Jie Liao, Wei-Hong Sha
BACKGROUND/AIM: The balance of blood CD8(+)CD28(+)/CD8(+)CD28(-) T cells has been verified to be vital for patients with ulcerative colitis (UC), but their role in inflammatory bowel disease (IBD) remains unknown. This investigation aimed to evaluate the efficiency of the balance in predicting the active stage in IBD patients. METHODS: Fifty-three IBD subjects, including 31 UC and 22 Crohn's disease (CD) patients, were enrolled, and their peripheral blood CD8(+)CD28(+) and CD8(+)CD28(-) T cell levels were tested using flow cytometry...
May 10, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28450817/the-emerging-therapeutic-role-of-medical-foods-for-gastrointestinal-disorders
#12
Brian P Ciampa, Emmanuel Reyes Ramos, Marie Borum, David B Doman
In addition to drugs approved by the US Food and Drug Administration (FDA) that treat, cure, or mitigate disease, medical foods are a tool to help manage chronic conditions and diseases. A medical food, according to the FDA, is a food that is developed to be eaten or administered enterally under the guidance of a physician and that is meant for the specific dietary management of a condition or disease for which distinctive nutritional requirements, based upon known scientific principles, are established by medical evaluation...
February 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28368910/iron-supplements-modulate-colon-microbiota-composition-and-potentiate-the-protective-effects-of-probiotics-in-dextran-sodium-sulfate-induced-colitis
#13
Marco Constante, Gabriela Fragoso, Joseph Lupien-Meilleur, Annie Calvé, Manuela M Santos
BACKGROUND: Iron is an important nutrient for both the host and colonizing bacteria. Oral iron supplementation may impact the composition of the microbiota and can be particularly damaging to patients suffering from inflammatory bowel disease (IBD). However, patients with IBD may require iron supplementation to treat their anemia. METHODS: We fed mice with diets supplemented with ferrous sulfate at different doses (5, 50, and 500 mg of iron/kg chow) and with different iron formulations (ferrous sulfate, ferrous bisglycinate and ferric ethylenediaminetetraacetic acid [FEDTA]), and analyzed the effects on the composition of the gut microbiota by 16S ribosomal RNA gene sequencing...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28339520/efficacy-of-bacillus-subtilis-and-bacitracin-methylene-disalicylate-on-growth-performance-digestibility-blood-metabolites-immunity-and-intestinal-microbiota-after-intramuscular-inoculation-with-escherichia-coli-in-broilers
#14
M Manafi, S Khalaji, M Hedayati, N Pirany
This experiment was conducted to evaluate the effect of Bacillus subtilis (BS) on broiler performance and health after intramuscular inoculation with E. coli and compare its effect with a growth promoter antibiotic. In a completely randomized design manner, 360 male Ross 308 chicks were divided into 6 treatments and 5 replicates of 12 chicks in each replicate. Experimental treatments included control diet, control + E. coli (0.5 mL of culture containing 108 CFU of E. coli/ml), control + 0.1% BS, control + 0...
May 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28294322/probiotics-are-a-good-choice-in-remission-of-inflammatory-bowel-diseases-a-meta-analysis-and-systematic-review
#15
Mahboube Ganji-Arjenaki, Mahmoud Rafieian-Kopaei
Altered gut bacteria and bacterial metabolic pathways are two important factors in initiation and progression of inflammatory bowel disease (IBD). However, efficacy of probiotics in remission of patients with IBD has not been characterized. This study was performed on the studies that specifically assessed the efficacy of probiotics in attaining clinical response on patients with various types of IBD. The efficacy of variant species of probiotics in different conditions and the influence of study quality in outcomes of randomized controlled trials (RCTs) were also assessed...
March 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28293937/gut-microbiota-and-inflammatory-bowel-disease-an-update
#16
Grainne Holleran, Loris R Lopetuso, Gianluca Ianiro, Silvia Pecere, Marco Pizzoferrato, Valentina Petito, Cristina Graziani, Deirdre Mc Namara, Antonio Gasbarrini, Franco Scaldaferri
Major advances have occurred in the knowledge of the pathogenesis of Inflammatory Bowel Disease (IBD) over the last decade, and perhaps the most major, and clinically advantageous of these advances has been the discovery of the microbiome as a key multifaceted component of inflammation. The Gut microbiome is the largest known group of cells in the body, and is now recognised as an organ in its own right. Initial studies looking at a possible role of bacterial manipulation of the immune system in IBD, looked at identifying a specific bacterial species, and were not representative of a feasible model of inflammation in IBD overall...
March 14, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28293233/the-soil-bacterium-methylococcus-capsulatus-bath-interacts-with-human-dendritic-cells-to-modulate-immune-function
#17
Stine Indrelid, Charlotte Kleiveland, René Holst, Morten Jacobsen, Tor Lea
The prevalence of inflammatory bowel disease (IBD) has increased in Western countries during the course of the twentieth century, and is evolving to be a global disease. Recently we showed that a bacterial meal of a non-commensal, non-pathogenic methanotrophic soil bacterium, Methylococcus capsulatus Bath prevents experimentally induced colitis in a murine model of IBD. The mechanism behind the effect has this far not been identified. Here, for the first time we show that M. capsulatus, a soil bacterium adheres specifically to human dendritic cells, influencing DC maturation, cytokine production, and subsequent T cell activation, proliferation and differentiation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28270247/gut-brain-actions-underlying-comorbid-anxiety-and-depression-associated-with-inflammatory-bowel-disease
#18
Áine Abautret-Daly, Elaine Dempsey, Adolfo Parra-Blanco, Carlos Medina, Andrew Harkin
Introduction Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD...
March 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28239318/maternal-and-fetal-outcomes-in-pregnant-japanese-women-with-inflammatory-bowel-disease-our-experience-with-a-series-of-23-cases
#19
Naoki Minami, Minoru Matsuura, Yorimitsu Koshikawa, Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Hiroshi Nakase
BACKGROUND/AIMS: Our physicians work to expand the possibilities to treat female patients with inflammatory bowel disease (IBD) who wish to become pregnant. Although many drugs, including 5-aminosalicylate (5-ASA), corticosteroids, immunomodulators, and biologics, are used safely during pregnancy, few reports have described the therapeutic regimen throughout pregnancy and the management of patients who relapse during pregnancy precisely. The aim of this study was to assess the management of patients with IBD during pregnancy...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28179904/applications-of-genetically-modified-immunobiotics-with-high-immunoregulatory-capacity-for-treatment-of-inflammatory-bowel-diseases
#20
REVIEW
Suguru Shigemori, Takeshi Shimosato
Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, are chronic inflammatory diseases characterized by dysregulated immune responses of the gastrointestinal tract. In recent years, the incidence of IBDs has increased in developed nations, but their prophylaxis/treatment is not yet established. Site-directed delivery of molecules showing anti-inflammatory properties using genetically modified (gm)-probiotics shows promise as a new strategy for the prevention and treatment of IBD...
2017: Frontiers in Immunology
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