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https://www.readbyqxmd.com/read/29350603/decision-tree-analysis-in-subarachnoid-hemorrhage-prediction-of-outcome-parameters-during-the-course-of-aneurysmal-subarachnoid-hemorrhage-using-decision-tree-analysis
#1
Isabel Charlotte Hostettler, Carl Muroi, Johannes Konstantin Richter, Josef Schmid, Marian Christoph Neidert, Martin Seule, Oliver Boss, Athina Pangalu, Menno Robbert Germans, Emanuela Keller
OBJECTIVE The aim of this study was to create prediction models for outcome parameters by decision tree analysis based on clinical and laboratory data in patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS The database consisted of clinical and laboratory parameters of 548 patients with aSAH who were admitted to the Neurocritical Care Unit, University Hospital Zurich. To examine the model performance, the cohort was randomly divided into a derivation cohort (60% [n = 329]; training data set) and a validation cohort (40% [n = 219]; test data set)...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29344951/the-rise-of-a-novel-classification-system-for-endometrial-carcinoma-integration-of-molecular-subclasses
#2
REVIEW
Jessica McAlpine, Alicia Leon-Castillo, Tjalling Bosse
Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly clear that this heterogeneity may be a function of the diversity of the underlying molecular alterations. Recent large scale genomic studies have revealed that endometrial cancer can be divided into at least four distinct molecular subtypes, with well described underlying genomic aberrations. These subtypes can be reliably delineated and carry significant prognostic as well as predictive information; embracing and incorporating them into clinical practice is thus attractive...
January 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29340679/effect-of-laparoscopic-sleeve-gastrectomy-vs-laparoscopic-roux-en-y-gastric-bypass-on-weight-loss-in-patients-with-morbid-obesity-the-sm-boss-randomized-clinical-trial
#3
Ralph Peterli, Bettina Karin Wölnerhanssen, Thomas Peters, Diana Vetter, Dino Kröll, Yves Borbély, Bernd Schultes, Christoph Beglinger, Jürgen Drewe, Marc Schiesser, Philipp Nett, Marco Bueter
Importance: Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs the standard Roux-en-Y gastric bypass procedure is unknown. Objective: To determine whether there are differences between sleeve gastrectomy and Roux-en-Y gastric bypass in terms of weight loss, changes in comorbidities, increase in quality of life, and adverse events. Design, Setting, and Participants: The Swiss Multicenter Bypass or Sleeve Study (SM-BOSS), a 2-group randomized trial, was conducted from January 2007 until November 2011 (last follow-up in March 2017)...
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29337917/the-hydrocolor-app-above-water-measurements-of-remote-sensing-reflectance-and-turbidity-using-a-smartphone-camera
#4
Thomas Leeuw, Emmanuel Boss
HydroColor is a mobile application that utilizes a smartphone's camera and auxiliary sensors to measure the remote sensing reflectance of natural water bodies. HydroColor uses the smartphone's digital camera as a three-band radiometer. Users are directed by the application to collect a series of three images. These images are used to calculate the remote sensing reflectance in the red, green, and blue broad wavelength bands. As with satellite measurements, the reflectance can be inverted to estimate the concentration of absorbing and scattering substances in the water, which are predominately composed of suspended sediment, chlorophyll, and dissolved organic matter...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29336067/treatment-of-allergic-rhinitis-using-mobile-technology-with-real-world-data-the-mask-observational-pilot-study
#5
REVIEW
J Bousquet, S Arnavielhe, A Bedbrook, G Alexis-Alexandre, M van Eerd, R Murray, G W Canonica, M Illario, E Menditto, G Passalacqua, C Stellato, M Triggiani, P Carreiro-Martins, J Fonseca, M Morais Almeida, L Nogueira-Silva, A M Pereira, A Todo Bom, I Bosse, D Caimmi, P Demoly, P Devillier, J F Fontaine, J Just, G L Onorato, M L Kowalski, P Kuna, B Samolinski, J M Anto, J Mullol, A Valero, P V Tomazic, K C Bergmann, T Keil, L Klimek, R Mösgues, S Shamai, T Zuberbier, E Murphy, Peter McDowall, D Price, D Ryan, A Sheikh, N H Chavannes, W J Fokkens, V Kvedariene, A Valiulis, C Bachert, P W Hellings, I Kull, E Melén, M Wickman, C Bindslev-Jensen, E Eller, T Haahtela, E Valovirta, N G Papadopoulos, I Annesi-Maesano, M Bewick, S Bosnic-Anticevich, A A Cruz, G De Vries, B Gemicioglu, D Larenas-Linnemann, D Laune, E Mathieu-Dupas, R E O'Hehir, F Portejoie, V Siroux, O Spranger, O VandenPlas, A Yorgancioglu
BACKGROUND: Large observational implementation studies are needed to triangulate the findings from randomized control trials (RCTs) as they reflect "real world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real life treatment of allergic rhinitis using mobile technology. METHODS: A mobile phone app (Allergy Diary, freely available Google Play and Apple App stores) collects the data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for 15 countries...
January 15, 2018: Allergy
https://www.readbyqxmd.com/read/29329799/cardiac-surgery-combined-with-bypass-from-the-ascending-aorta-to-the-bilateral-femoral-arteries-for-severe-aorto-iliac-occlusion-a-case-series
#6
Côme Bosse, Ramzi Ramadan, Dominique Fabre, Julien Guihaire
No abstract text is available yet for this article.
December 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29329227/fermentation-guided-natural-products-isolation-of-a-grape-berry-triacylglyceride-that-enhances-ethyl-ester-production
#7
Christopher L Blackford, Eric G Dennis, Robert A Keyzers, Claudia Schueuermann, Robert D Trengove, Paul K Boss
A full understanding of the origin, formation and degradation of volatile compounds that contribute to wine aroma is required before wine style can be effectively managed. Fractionation of grapes represents a convenient and robust method to simplify the grape matrix to enhance our understanding of the grape contribution to volatile compound production during yeast fermentation. In this study, acetone extracts of both Riesling and Cabernet Sauvignon grape berries were fractionated and model wines produced by spiking aliquots of these grape fractions into model grape juice must and fermented...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29328731/high-resolution-quantum-sensing-with-shaped-control-pulses
#8
J Zopes, K Sasaki, K S Cujia, J M Boss, K Chang, T F Segawa, K M Itoh, C L Degen
We investigate the application of amplitude-shaped control pulses for enhancing the time and frequency resolution of multipulse quantum sensing sequences. Using the electronic spin of a single nitrogen-vacancy center in diamond and up to 10 000 coherent microwave pulses with a cosine square envelope, we demonstrate 0.6-ps timing resolution for the interpulse delay. This represents a refinement by over 3 orders of magnitude compared to the 2-ns hardware sampling. We apply the method for the detection of external ac magnetic fields and nuclear magnetic resonance signals of ^{13}C spins with high spectral resolution...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29326228/bringing-social-context-into-the-conversation-about-pediatric-long-term-ventilation
#9
Carrie M Henderson, Benjamin S Wilfond, Renee D Boss
No abstract text is available yet for this article.
January 11, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29315086/six2-gene-haploinsufficiency-leads-to-a-recognizable-phenotype-with-ptosis-frontonasal-dysplasia-and-conductive-hearing-loss
#10
Alina Henn, Harald Weng, Simon Novak, Günther Rettenberger, Andreas Gerhardinger, Eva Rossier, Birgit Zirn
Heterozygous microdeletions of chromosome 2p21 encompassing only the SIX2 gene have been described in two families to date. The clinical phenotype comprised autosomal-dominant inherited frontonasal dysplasia with ptosis in one family. In the second family, conductive hearing loss was the major clinical feature described; however, the affected persons also had ptosis. Here, we present a large family combining all three predescribed features of SIX2 gene deletion. The phenotype in four affected family members in three generations consisted of bilateral congenital ptosis, epicanthus inversus, frontonasal dysplasia with broad nasal bridge and hypertelorism, frontal bossing and large anterior fontanel in childhood, narrow ear canals, and mild conductive hearing loss with onset in childhood...
January 8, 2018: Clinical Dysmorphology
https://www.readbyqxmd.com/read/29311368/education-research-difficult-conversations-in-neurology-lessons-learned-from-medical-students
#11
Monica E Lemmon, Charlene Gamaldo, Rachel Marie E Salas, Ankita Saxena, Tiana E Cruz, Renee D Boss, Roy E Strowd
OBJECTIVE: To characterize features of medical student exposure to difficult conversations during a neurology core clerkship. METHODS: This was a cross-sectional concurrent nested mixed methods study, and all students rotating through a required neurology clerkship between 2014 and 2015 were enrolled. Data collection included an electronic communication tracker, baseline and end-of-clerkship surveys, and 4 facilitated focus groups. Students were asked to log exposure to patient-clinician conversations about (1) new disability, (2) poor prognosis, (3) prognostic uncertainty (4), terminal diagnosis, and (5) end-of-life care...
January 9, 2018: Neurology
https://www.readbyqxmd.com/read/29301960/genomic-correlates-of-response-to-immune-checkpoint-therapies-in-clear-cell-renal-cell-carcinoma
#12
Diana Miao, Claire A Margolis, Wenhua Gao, Martin H Voss, Wei Li, Dylan J Martini, Craig Norton, Dominick Bossé, Stephanie M Wankowicz, Dana Cullen, Christine Horak, Megan Wind-Rotolo, Adam Tracy, Marios Giannakis, Frank Stephen Hodi, Charles G Drake, Mark W Ball, Mohamad E Allaf, Alexandra Snyder, Matthew D Hellmann, Thai Ho, Robert J Motzer, Sabina Signoretti, William G Kaelin, Toni K Choueiri, Eliezer M Van Allen
Immune checkpoint inhibitors targeting the programmed cell death-1 receptor (PD-1) improve survival in a subset of patients with clear cell renal cell carcinoma (ccRCC). To identify genomic alterations in ccRCC that correlate with response to anti-PD-1 monotherapy, we performed whole exome sequencing of metastatic ccRCC from 35 patients. We found that clinical benefit was associated with loss-of-function mutations in the PBRM1 gene (p=0.012), which encodes a subunit of a SWI/SNF chromatin remodeling complex (the PBAF subtype)...
January 4, 2018: Science
https://www.readbyqxmd.com/read/29295679/medicina-ex-machina-machine-learning-in-der-medizin
#13
Anton S Becker, Christian Blüthgen, Urs Mühlematter, Andreas Boss
No abstract text is available yet for this article.
January 2018: Praxis
https://www.readbyqxmd.com/read/29288200/ezh2-represses-the-b-cell-transcriptional-program-and-regulates-antibody-secreting-cell-metabolism-and-antibody-production
#14
Muyao Guo, Madeline J Price, Dillon G Patterson, Benjamin G Barwick, Robert R Haines, Anna K Kania, John E Bradley, Troy D Randall, Jeremy M Boss, Christopher D Scharer
Epigenetic remodeling is required during B cell differentiation. However, little is known about the direct functions of epigenetic enzymes in Ab-secreting cells (ASC) in vivo. In this study, we examined ASC differentiation independent of T cell help and germinal center reactions using mice with inducible or B cell-specific deletions of Ezh2 Following stimulation with influenza virus or LPS, Ezh2-deficient ASC poorly proliferated and inappropriately maintained expression of inflammatory pathways, B cell-lineage transcription factors, and Blimp-1-repressed genes, leading to fewer and less functional ASC...
December 29, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29287922/gynaecological-neoplasms-in-common-familial-syndromes-lynch-and-hboc
#15
REVIEW
Carla Bartosch, Blaise Clarke, Tjalling Bosse
Recognising hereditary predisposition in a cancer patient has implications both for the patient and the patient's kindred. For the latter, cascade germline testing can reassure those not-at-risk family members while carriers can be enrolled in cancer screening and prevention programs that are medically effective and economically sustainable for health care systems. Furthermore, in many of these syndromes, ramifications of molecular phenotypes are increasing, and it is now emerging that, in addition, they convey prognostic and predictive information...
December 26, 2017: Pathology
https://www.readbyqxmd.com/read/29287743/a-novel-ex-vivo-method-for-measuring-whole-brain-metabolism-in-model-systems
#16
Kathryn E Neville, Timothy L Bosse, Mia Klekos, John F Mills, Steven E Weicksel, James S Waters, Marla Tipping
BACKGROUND: Many neuronal and glial diseases have been associated with changes in metabolism. Therefore, metabolic reprogramming has become an important area of research to better understand disease at the cellular level, as well as to identify targets for treatment. Model systems are ideal for interrogating metabolic questions in a tissue dependent context. However, while new tools have been developed to study metabolism in cultured cells there has been less progress towards studies in vivo and ex vivo...
December 26, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29284065/inner-tegument-proteins-of-herpes-simplex-virus-are-sufficient-for-intracellular-capsid-motility-in-neurons-but-not-for-axonal-targeting
#17
Anna Buch, Oliver Müller, Lyudmila Ivanova, Katinka Döhner, Dagmara Bialy, Jens B Bosse, Anja Pohlmann, Anne Binz, Maike Hegemann, Claus-Henning Nagel, Martin Koltzenburg, Abel Viejo-Borbolla, Bodo Rosenhahn, Rudolf Bauerfeind, Beate Sodeik
Upon reactivation from latency and during lytic infections in neurons, alphaherpesviruses assemble cytosolic capsids, capsids associated with enveloping membranes, and transport vesicles harboring fully enveloped capsids. It is debated whether capsid envelopment of herpes simplex virus (HSV) is completed in the soma prior to axonal targeting or later, and whether the mechanisms are the same in neurons derived from embryos or from adult hosts. We used HSV mutants impaired in capsid envelopment to test whether the inner tegument proteins pUL36 or pUL37 necessary for microtubule-mediated capsid transport were sufficient for axonal capsid targeting in neurons derived from the dorsal root ganglia of adult mice...
December 28, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29283209/encapsulated-optically-responsive-cell-systems-toward-smart-implants-in-biomedicine
#18
REVIEW
Christophe Boss, Nicolas Bouche, Umberto De Marchi
Managing increasingly prevalent chronic diseases will require close continuous monitoring of patients. Cell-based biosensors may be used for implantable diagnostic systems to monitor health status. Cells are indeed natural sensors in the body. Functional cellular systems can be maintained in the body for long-term implantation using cell encapsulation technology. By taking advantage of recent progress in miniaturized optoelectronic systems, the genetic engineering of optically responsive cells may be combined with cell encapsulation to generate smart implantable cell-based sensing systems...
December 28, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29261537/work-family-culture-within-hospitals-an-interdepartmental-analysis-of-employee-engagement-and-retention
#19
Matthew B Perrigino, Benjamin B Dunford, Matt Troup, R Wayne Boss, David S Boss
BACKGROUND: Helping employees balance their work and family needs is increasingly pivotal for attracting, engaging, and retaining key talent in health care. Yet, emerging theory and anecdotal evidence suggest that, within organizations, there is considerable variation between departments or units regarding how employees' lives outside work are supported. Despite top management's efforts to develop a unified organizational work-family culture, departments have a tendency to take on their own culture, norms, and traditions such that some are more supportive than others...
December 19, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/29260070/ocular-dirofilariasis-ophthalmic-implication-of-climate-change-on-vector-borne-parasites
#20
Joseph D Boss, Gabriel Sosne, Asheesh Tewari
Purpose: To describe a geographically rare case of ophthalmic dirofilariasis. Observations: An 81-year-old male of good socioeconomic status living in the state of Michigan in the United States, presented to the eye clinic with a painful red left eye. He had not traveled outside of the state of Michigan in over three years. He was found to have a 7 cm long subconjunctival roundworm, which was ultimately extracted. Conclusions and importance: With increasing global temperatures, ocular dirofilariasis is being introduced in more northern climates and should be included in the differential diagnosis in areas previously isolated from these vector-borne parasites...
September 2017: American Journal of Ophthalmology Case Reports
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