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https://www.readbyqxmd.com/read/28922265/-stuck-in-the-icu-caring-for-children-with-chronic-critical-illness
#1
Carrie M Henderson, Erin P Williams, Miriam C Shapiro, Emily Hahn, Laura Wright-Sexton, Nancy Hutton, Renee D Boss
OBJECTIVE: Neonatal ICUs and PICUs increasingly admit patients with chronic critical illness: children whose medical complexity leads to recurrent and prolonged ICU hospitalizations. We interviewed participants who routinely care for children with chronic critical illness to describe their experiences with ICU care for pediatric chronic critical illness. DESIGN: Semi-structured interviews. Interviews were transcribed and analyzed for themes. SETTING: Stakeholders came from five regions (Seattle, WA; Houston, TX; Jackson, MS; Baltimore, MD; and Philadelphia, PA)...
September 15, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28917833/values-based-shared-decision-making-in-the-antenatal-period
#2
REVIEW
Stephanie K Kukora, Renee D Boss
Despite advances in life-saving technology for critically ill neonates, challenges continue to arise for infants delivered with extreme prematurity, congenital anomalies, and genetic conditions that exceed the limits of currently available interventions. In these situations, parents are forced to make cognitively and emotionally difficult decisions, in discussion with a neonatologist, regarding how aggressively to provide supportive measures at the time of delivery and at what point burdens of therapy outweigh benefits...
September 13, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28913930/accuracy-repeatability-and-interplatform-reproducibility-of-t1-quantification-methods-used-for-dce-mri-results-from-a-multicenter-phantom-study
#3
Octavia Bane, Stefanie J Hectors, Mathilde Wagner, Lori L Arlinghaus, Madhava P Aryal, Yue Cao, Thomas L Chenevert, Fiona Fennessy, Wei Huang, Nola M Hylton, Jayashree Kalpathy-Cramer, Kathryn E Keenan, Dariya I Malyarenko, Robert V Mulkern, David C Newitt, Stephen E Russek, Karl F Stupic, Alina Tudorica, Lisa J Wilmes, Thomas E Yankeelov, Yi-Fei Yen, Michael A Boss, Bachir Taouli
PURPOSE: To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. METHODS: A T1 phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery)...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28899974/genomic-characterisation-of-vulvar-pre-cancers-identifies-distinct-molecular-subtypes-with-prognostic-significance
#4
Linda Nooij, Natalja Ter Haar, Dina Ruano, Natalia Rakislova, Vincent T H B M Smit, J Baptist M Z Trimbos, Jaume Ordi, Mariette Ie van Poelgeest, Tjalling Bosse, Tom van Wezel
Background Vulvar cancer (VC) can be sub-classified by human papilloma virus (HPV) status. HPV negative VCs frequently harbour TP53 mutations, however in-depth analysis of other potential molecular genetic alterations is lacking. We comprehensively assessed somatic mutations in a large series of vulvar (pre)cancers. Methods We performed targeted next generation sequencing (17 genes), p53 immunohistochemistry and HPV-testing on 36 VC and 82 precursors (sequencing cohort). Subsequently, the prognostic significance of the three subtypes identified in the sequencing cohort was assessed in a series of 236 VC-patients (follow-up cohort)...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28898695/identification-of-gpc2-as-an-oncoprotein-and-candidate-immunotherapeutic-target-in-high-risk-neuroblastoma
#5
Kristopher R Bosse, Pichai Raman, Zhongyu Zhu, Maria Lane, Daniel Martinez, Sabine Heitzeneder, Komal S Rathi, Nathan M Kendsersky, Michael Randall, Laura Donovan, Sorana Morrissy, Robyn T Sussman, Doncho V Zhelev, Yang Feng, Yanping Wang, Jennifer Hwang, Gonzalo Lopez, Jo Lynne Harenza, Jun S Wei, Bruce Pawel, Tricia Bhatti, Mariarita Santi, Arupa Ganguly, Javed Khan, Marco A Marra, Michael D Taylor, Dimiter S Dimitrov, Crystal L Mackall, John M Maris
We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target safety and efficacy. Here, we show that GPC2 is a strong candidate immunotherapeutic target in this childhood cancer. We demonstrate high GPC2 expression in neuroblastoma due to MYCN transcriptional activation and/or somatic gain of the GPC2 locus. We confirm GPC2 to be highly expressed on most neuroblastomas, but not detectable at appreciable levels in normal childhood tissues...
September 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28898689/scratching-the-surface-of-immunotherapeutic-targets-in-neuroblastoma
#6
Clare F Malone, Kimberly Stegmaier
In this issue of Cancer Cell, Bosse et al. report GPC2 as a therapeutic target in neuroblastoma. They show that GPC2 is selectively expressed on the cell surface of neuroblastoma and is a dependency in this disease. Moreover, they demonstrate the therapeutic potential of an antibody-drug conjugate targeting GPC2.
September 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28889112/interplay-between-cigarette-smoking-and%C3%A2-pulmonary-reverse-lipid-transport
#7
Éric Jubinville, Maude Talbot, Jean-Christophe Bérubé, Mélanie Hamel-Auger, Michaël Maranda-Robitaille, Marie-Josée Beaulieu, Sophie Aubin, Marie-Ève Paré, David G Kallend, Benoit Arsenault, Yohan Bossé, Mathieu C Morissette
Reverse lipid transport is critical to maintain homeostasis. Smoking causes lipid accumulation in macrophages, therefore suggesting suboptimal reverse lipid transport mechanisms. In this study, we investigated the interplay between smoking and reverse lipid transport and the consequences on smoking-induced lung and peripheral alterations.To investigate the relationship between smoking and reverse lipid transport, we used a clinical lung gene expression dataset and a mouse model of cigarette smoke exposure. We also used ApoA-1(-/-) mice, with reduced reverse lipid transport capacity, and a recombinant ApoA-1 Milano/phospholipid complex (MDCO-216) to boost reverse lipid transport...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28888516/effects-of-animal-assisted-activities-on-biobehavioral-stress-responses-in-hospitalized-children-a-randomized-controlled-study
#8
Sandra M Branson, Lisa Boss, Nikhil S Padhye, Thea Trötscher, Alexandra Ward
PURPOSE: This study assessed the effectiveness of animal-assisted activities (AAA) on biobehavioral stress responses (anxiety, positive and negative affect, and salivary cortisol and C-reactive protein [CRP] levels) in hospitalized children. DESIGN AND METHODS: This was a randomized, controlled study. METHOD: Forty-eight participants were randomly assigned to receive a 10-minute AAA (n=24) or a control condition (n=24). Anxiety, positive and negative affect, and levels of salivary biomarkers were assessed before and after the intervention...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28878914/a-novel-keratin-13-variant-in-a-four-generation-family-with-white-sponge-nevus
#9
Stephanie B de Haseth, Egbert Bakker, Maarten H Vermeer, Hakima El Idrissi, Tjalling Bosse, Vincent T H B M Smit, Anna Terron-Kwiatkowski, W H Irwin McLean, Alexander A W Peters, Frederik J Hes
We report a novel KRT13 germ line variant that causes white sponge nevus (WSN) with mucosal dysplasia. Genital, vaginal, and cervical WSN were observed in four female patients, of whom two had premalignant cervical lesions at young age. Two of the 12 patients with oral WSN developed oral squamous cell carcinoma.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28877988/il-17a-produced-by-innate-lymphoid-cells-is-essential-for-intestinal-ischemia-reperfusion-injury
#10
Mayya Geha, Maria G Tsokos, Robin E Bosse, Tatyana Sannikova, Yoichiro Iwakura, Jurandir J Dalle Lucca, Rene De Waal Malefyt, George C Tsokos
Ischemia-reperfusion (IR) injury to the small intestine following clamping of the superior mesenteric artery results in an intense local inflammatory response that is characterized by villous damage and neutrophil infiltration. IL-17A, a cytokine produced by a variety of cells in response to inflammatory cytokines released following tissue injury, has been implicated in IR injury. Using Il17a(-/-) , Il23r(-/-) , and Rorc(-/-) mice and administration of anti-IL-17A and anti-IL-23 neutralizing Abs to wild-type mice, we demonstrate that intestinal IR injury depends on IL-17A and that IL-17A is downstream of the binding of autoantibody to ischemia-conditioned tissues and subsequent complement activation...
September 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28877863/the-paget-trial-a-multicenter-observational-cohort-intervention-study-for-the-clinical-efficacy-safety-and-immunological-response-of-topical-5-imiquimod-cream-for-vulvar-paget-disease
#11
Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu
BACKGROUND: Vulvar Paget disease is a rare skin disorder, which is most common in postmenopausal Caucasian women. They usually present with an erythematous plaque that may show fine or typical "cake icing" scaling or ulceration that may cause itching, pain, irritation, or a burning sensation. Although most cases are noninvasive, vulvar Paget disease may be invasive or associated with an underlying vulvar or distant adenocarcinoma. The histological evidence of so-called "Paget cells" with abundant pale cytoplasm in the epithelium confirms the diagnosis...
September 6, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28870703/a-novel-mutation-at-antxr1-in-an-indian-patient-with-growth-retardation-alopecia-pseudoanodontia-optic-atrophy-syndrome
#12
Esita Chattopadhyay, Sandip Ghose, Anindita Ray, Nishat Anjum, Anjana Mazumdar, Bidyut Roy
OBJECTIVE: Growth retardation-alopecia-pseudoanodontia-optic atrophy (GAPO) syndrome (Online Mendelian Inheritance in Man [OMIM] ID 230740) is one of the rarest autosomal recessive syndromes. It is characterized by many phenotypes, including wide anterior fontanel, frontal bossing of the face, depressed nasal bridge, along with the 4 classic phenotypes contained in the name of the syndrome. Recent reports identified nonsense, missense, and splicing mutations at different exons of ANTXR1 responsible for GAPO syndrome in patients from different ethnic populations...
August 4, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28868209/oral-glycine-and-sodium-thiosulfate-for-lethal-cyanide-ingestion
#13
Matthew Brenner, Sarah M Azer, Kyung-Jin Oh, Chang Hoon Han, Jangwoen Lee, Sari B Mahon, Xiaohua Du, David Mukai, Tanya Burney, Mayer Saidian, Adriano Chan, Derek I Straker, Vikhyat S Bebarta, Gerry R Boss
OBJECTIVE: Accidental or intentional cyanide ingestion is an-ever present danger. Rapidly acting, safe, inexpensive oral cyanide antidotes are needed that can neutralize large gastrointestinal cyanide reservoirs. Since humans cannot be exposed to cyanide experimentally, we studied oral cyanide poisoning in rabbits, testing oral sodium thiosulfate with and without gastric alkalization. SETTING: University research laboratory. SUBJECTS: New Zealand white rabbits...
June 2017: Journal of Clinical Toxicology
https://www.readbyqxmd.com/read/28864553/language-matters-identifying-medically-complex-children-in-foster-care
#14
Erin P Williams, Rebecca R Seltzer, Renee D Boss
No abstract text is available yet for this article.
September 1, 2017: Pediatrics
https://www.readbyqxmd.com/read/28864222/upper-tract-urothelial-carcinomas-prognostic-factors-and-outcomes-in-patients-with-non-lymph-node-distant-metastasis
#15
Elena Sevillano, Lillian Werner, Dominick Bossé, Aly-Khan A Lalani, Stephanie A M Wankowicz, Guillermo de Velasco, Matthew Farina, Kevin Lundgren, Toni K Choueiri, Aranzazu González Del Alba, Joaquim Bellmunt
BACKGROUND: Upper tract urothelial carcinomas (UTUCs) are increasingly recognized as separate malignancies. Additional insight into clinical outcomes and key prognostic factors are needed. OBJECTIVES: To detail outcomes of patients with UTUCs recurring after radical nephroureterectomy (RNU) and to determine a risk score that predicts outcomes of patients with non-lymph node distant metastasis. DESIGN, SETTING, AND PARTICIPANTS: Chart review of all patients who had an extraurothelial recurrence after RNU for UTUC at Dana-Farber Cancer Institute between 2009 and 2014...
August 2, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28842989/consulting-dr-google-quality-of-online-resources-about-tympanostomy-tube-placement
#16
Vandra C Harris, Anne R Links, Paul Hong, Jonathan Walsh, Desi P Schoo, David E Tunkel, Charles M Stewart, Emily F Boss
OBJECTIVE: Tympanostomy tube (TT) placement is common in children; however, family-centeredness and utility of online information used for decision making and understanding is unknown. We evaluate the quality of leading Internet resources describing TT placement. STUDY DESIGN: Cross-sectional descriptive design. METHODS: We performed a Google (Menlo Park, CA) search for terms related to TTs. We defined quality using scaled readability measures (Flesch Reading Ease and Flesch-Kincaid Grade-Level), understandability and actionability (Patient Education Materials Assessment Tool), shared decision-making centrality (Center for Medicare and Medicaid Services informed consent guidelines), and clinical practice guideline (CPG) compatibility...
August 26, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28838956/adenylyl-cyclase-1-is-required-for-ethanol-induced-locomotor-sensitization-and-associated-increases-in-nmda-receptor-phosphorylation-and-function-in-the-dorsal-medial-striatum
#17
Kelly E Bosse, Max F Oginsky, Laura L Susick, Sailesh Ramalingam, Carrie R Ferrario, Alana C Conti
Neuroadaptive responses to chronic ethanol, such as behavioral sensitization, are associated with NMDA receptor (NMDAR) recruitment. Ethanol enhances GluN2B-containing NMDAR function and phosphorylation (Tyr-1472) of the GluN2B-NMDAR subunit in the dorsal medial striatum (DMS) through a protein kinase A (PKA)-dependent pathway. Ethanol-induced phosphorylation of PKA substrates is partially mediated by calcium-stimulated adenylyl cyclase 1 (AC1), which is enriched in the dorsal striatum. As such, AC1 is poised as an upstream modulator of ethanol-induced DMS neuroadaptations that promote drug responding and, thus, represents a therapeutic target...
August 24, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28833850/influence-of-breast-cancer-opportunistic-screening-on-aesthetic-surgical-outcome-a-single-center-retrospective-study-in-switzerland
#18
Magda Marcon, Konstantin Dedes, Zsuzsanna Varga, Thomas Frauenfelder, Andreas Boss
The aim of this retrospective study is to compare the surgical aesthetic outcome and breast cancer (BC) characteristics in patients with BC detected either by opportunistic screening or clinical diagnosis. 262 women undergoing surgery for BC between 2009 and 2012 were included. The following features were compared in the two groups of patients: (1) age at diagnosis; (2) family history of BC; (3) histology type; (4) tumor diameter; (5) local staging, and (6) type of surgical treatment. In 92/262 (35.1%) cases BC was detected by screening and 170/262 (64...
August 18, 2017: Breast Journal
https://www.readbyqxmd.com/read/28833441/-i-don-t-know-what-i-was-expecting-home-visits-by-neonatology-fellows-for-infants-discharged-from-the-nicu
#19
Janice E Hobbs, Megan M Tschudy, Brenda Hussey-Gardner, Jacky M Jennings, Renee D Boss
BACKGROUND: When families transition from the neonatal intensive care unit (NICU) to the home, they become responsible for their infant's daily medical needs. Though neonatology physicians prepare families for hospital discharge, it is unclear how much clinicians understand about how their teaching and instructions translate into home care. The goal of this study was to evaluate the influence of a home visiting program on neonatology fellows' understanding of family needs soon after hospital discharge...
August 22, 2017: Birth
https://www.readbyqxmd.com/read/28832203/the-fourth-extensor-compartment-artery-vascularized-bone-graft-of-the-distal-radius-for-cmc-fusion-in-the-treatment-of-carpal-boss-a-case-report
#20
Jorge G Boretto, David Fernandez-Fernandez, Gerardo Gallucci, Pablo De Carli
BACKGROUND: Carpometacarpal joints can be affected by traumatic or degenerative pathology. Although different techniques have been described to treat these conditions, most authors agree that arthrodesis is an effective treatment modality. Vascularized bone grafts of the distal radius have been used to treat carpal conditions, such as scaphoid nonunion or Kiënbock disease, and they have been shown to have several advantages over nonvascularized bone grafts. METHODS: We report a case of a carpal boss in a female patient treated with an arthrodesis of the second and third carpometacarpal joints by using the fourth extensor compartment artery vascularized bone graft...
September 2017: Hand: Official Journal of the American Association for Hand Surgery
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