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https://www.readbyqxmd.com/read/28107436/a-micro-ct-study-in-patients-with-breast-microcalcifications-using-a-mathematical-algorithm-to-assess-3d-structure
#1
David Kenkel, Zsuzsanna Varga, Heike Heuer, Konstantin J Dedes, Nicole Berger, Lukas Filli, Andreas Boss
PURPOSE: The aim of this study was to evaluate the relevance of the three-dimensional (3D) structure of breast microcalcifications (MC) as a predictor of malignancy using highly resolved micro-computed tomography (micro-CT) datasets of biopsy samples. MATERIAL AND METHODS: The study included 28 women with suspicious MC in their mammogram undergoing vacuum-assisted biopsy. Directly after the intervention, the specimens were scanned in a micro-CT with an isometric spatial resolution of 9 μm...
2017: PloS One
https://www.readbyqxmd.com/read/28089564/cardiorespiratory-fitness-after-transient-ischemic-attack-and-minor-ischemic-stroke-baseline-data-of-the-moveit-study
#2
H Myrthe Boss, IngerA Deijle, SanderM Van Schaik, EdwinC de Melker, BobT J van den Berg, HenryC Weinstein, MirjamI Geerlings, L Jaap Kappelle, RenskeM Van den Berg-Vos
BACKGROUND: Cardiorespiratory fitness (CRF) is reduced in patients with stroke. It is unclear whether it is also reduced in patients with a transient ischemic attack (TIA) or minor stroke. We investigated the CRF in patients with a recent TIA or minor stroke and explored which determinants are associated with a lower fitness. METHODS: In 113 patients with a recent TIA or minor ischemic stroke (64 (SD = 10) years of age; 49 (IQR 27-86) days post TIA or stroke), the peak oxygen consumption (VO2peak) was determined in a symptom-limited ramp exercise test...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28088921/red-flags-a-case-series-of-clinician-family-communication-challenges-in-the-context-of-chd
#3
Priya Sekar, Katie L Marcus, Erin P Williams, Renee D Boss
We describe three cases of newborns with complex CHD characterised by communication challenges. These communication challenges were categorised as patient, family, or system-related red flags. Strategies for addressing these red flags were proposed, for the goal of optimising care and improving quality of life in this vulnerable population.
January 16, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28077594/the-n-linking-glycosylation-system-from-actinobacillus-pleuropneumoniae-is-required-for-adhesion-and-has-potential-use-in-glycoengineering
#4
Jon Cuccui, Vanessa S Terra, Janine T Bossé, Andreas Naegeli, Sherif Abouelhadid, Yanwen Li, Chia-Wei Lin, Prerna Vohra, Alexander W Tucker, Andrew N Rycroft, Duncan J Maskell, Markus Aebi, Paul R Langford, Brendan W Wren
Actinobacillus pleuropneumoniae is a mucosal respiratory pathogen causing contagious porcine pleuropneumonia. Pathogenesis studies have demonstrated a major role for the capsule, exotoxins and outer membrane proteins. Actinobacillus pleuropneumoniae can also glycosylate proteins, using a cytoplasmic N-linked glycosylating enzyme designated NGT, but its transcriptional arrangement and role in virulence remains unknown. We investigated the NGT locus and demonstrated that the putative transcriptional unit consists of rimO, ngt and a glycosyltransferase termed agt...
January 2017: Open Biology
https://www.readbyqxmd.com/read/28067973/simultaneous-multislice-readout-segmented-echo-planar-imaging-for-accelerated-diffusion-tensor-imaging-of-the-mandibular-nerve-a-feasibility-study
#5
Andrei Manoliu, Michael Ho, Marco Piccirelli, Daniel Nanz, Lukas Filli, Evelyn Dappa, Wei Liu, Dominik A Ettlin, Andreas Boss, Gustav Andreisek, Felix P Kuhn
PURPOSE: To assess the feasibility of diffusion tensor imaging (DTI) using simultaneous multislice (SMS) acquisition with blipped controlled aliasing in parallel imaging (CAIPI) for accelerated readout-segmented echo planar imaging (rs-EPI) of the mandibular nerves. DTI of the mandibular nerves using EPI is challenging due to susceptibility artifacts. Rs-EPI is less prone to artifacts but associated with longer scan durations. MATERIALS AND METHODS: Eight asymptomatic volunteers were imaged at 3T using a 64-channel head/neck coil...
January 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28062427/novel-sleep-management-method-in-a-toddler-displaying-fear-and-trauma-the-boss-of-my-sleep-book
#6
Sarah Blunden
Sleep problems in toddlers occur in ∼40% of children and increase the likelihood of postnatal depression. Most sleep training in toddlers requires contact with a trained professional, and requires a parent to ignore their child's cries, causing distress to many children and parents, increasing attrition and leaving families untreated and at risk. This case study reports success in significantly ameliorating sleep reluctance and bedtime fears in a sleep disturbed toddler with a history of trauma. It uses a novel use of bedtime behaviour management with some positive reinforcement techniques, called the Boss of My Sleep book: a non-cry, online (thus readily and cheaply available without a trained professional) sleep intervention...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28060234/reorientational-proximal-femoral-osteotomies-for-arthrogrypotic-hip-contractures
#7
Harold Jacob Pieter van Bosse, Roger E Saldana
BACKGROUND: Severe hip contractures in arthrogrypsosis are multiplanar, which can preclude or can greatly complicate sitting and ambulation. The reorientational osteotomy at the intertrochanteric level preserves preoperative hip motion but moves it to a more functional domain. We retrospectively compared preoperative and postoperative hip motion and evaluated the ambulatory abilities of patients who underwent the procedure. METHODS: Since 2008, 65 patients with arthrogryposis had 119 reorientational proximal femoral osteotomies with a minimum follow-up of 2 years...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28053219/a-unique-capsule-locus-in-the-newly-designated-actinobacillus-pleuropneumoniae-serovar-16-and-development-of-a-diagnostic-pcr
#8
Janine T Bossé, Yanwen Li, Rita Sárközi, Marcelo Gottschalk, Øystein Angen, Katerina Nedbalcova, Andrew N Rycroft, László Fodor, Paul R Langford
Actinobacillus pleuropneumoniae causes pleuropneumonia, an economically significant, lung disease of pigs. Recently, isolates of A. pleuropneumoniae that were serologically distinct from the previously characterized 15 serovars were described, and a proposal put forward that they comprised a new serovar 16. Here we used whole genome sequencing of the proposed serovar 16 reference strain A-85/14 to confirm presence of a unique capsular polysaccharide biosynthetic locus. For molecular diagnostics, primers were designed from the capsule locus of A-85/14 and a PCR formulated that differentiated serovar 16 isolates from all 15 known serovars, and other common respiratory pathogenic/commensal bacteria of pigs...
January 4, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28052554/antiepileptic-drugs-and-risk-of-suicide-attempts-a-case-control-study-exploring-the-impact-of-underlying-medical-conditions
#9
Lamiae Grimaldi-Bensouda, Clementine Nordon, Michel Rossignol, Vincent Jardon, Virginie Boss, Frédérique Warembourg, Robert Reynolds, Xavier Kurz, Frédéric Rouillon, Lucien Abenhaim
PURPOSE: Randomized-controlled trials and claims databases suggest that antiepileptic drug (AED) use may increase the risk of suicide attempts (SA). The present case-control study explores the impact of underlying indications on this potential association. METHODS: Physicians collected the medical history; prior 12-month drug use was obtained from standardized telephone interviews with patients. The association between AED use and SA was explored using multivariate conditional logistic regression...
January 3, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28052263/amplification-of-adipogenic-commitment-by-vstm2a
#10
Blandine Secco, Étienne Camiré, Marc-Antoine Brière, Alexandre Caron, Armande Billong, Yves Gélinas, Anne-Marie Lemay, Kevin M Tharp, Peter L Lee, Stéphane Gobeil, Jean V Guimond, Natacha Patey, David A Guertin, Andreas Stahl, Élie Haddad, David Marsolais, Yohan Bossé, Kivanc Birsoy, Mathieu Laplante
Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28050151/eastern-canadian-gastrointestinal-cancer-consensus-conference-2016
#11
D Bossé, T Ng, C Ahmad, A Alfakeeh, I Alruzug, J Biagi, J Brierley, P Chaudhury, S Cleary, B Colwell, C Cripps, L A Dawson, M Dorreen, E Ferland, P Galiatsatos, S Girard, S Gray, F Halwani, N Kopek, A Mahmud, G Martel, L Robillard, B Samson, M Seal, J Siddiqui, L Sideris, S Snow, M Thirwell, M Vickers, R Goodwin, R Goel, T Hsu, E Tsvetkova, B Ward, T Asmis
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016 was held in Montreal, Quebec, 5-7 February. Experts in radiation oncology, medical oncology, surgical oncology, and infectious diseases involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics: ■ Follow-up and survivorship of patients with resected colorectal cancer■ Indications for liver metastasectomy■ Treatment of oligometastases by stereotactic body radiation therapy■ Treatment of borderline resectable and unresectable pancreatic cancer■ Transarterial chemoembolization in hepatocellular carcinoma■ Infectious complications of antineoplastic agents...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28049106/linking-uterine-serous-carcinoma-to-brca1-2-associated-cancer-syndrome-a-meta-analysis-and-case-report
#12
REVIEW
M M de Jonge, A L Mooyaart, M P G Vreeswijk, C D de Kroon, T van Wezel, C J van Asperen, V T H B M Smit, O M Dekkers, T Bosse
BACKGROUND: Uterine serous carcinoma (USC) shows greater morphological, clinical and molecular similarities to high-grade ovarian tubal serous carcinoma than to other types of endometrial cancer. As high-grade ovarian tubal serous carcinoma is known to be associated with BRCA1/2 pathogenic germline mutations (PMs), we aimed to explore whether USC is also a constituent of hereditary breast and ovarian cancer syndrome. METHODS: Pubmed, EMBASE and Web of Science were searched in July 2016 for articles assessing the association between USC and germline BRCA1/2-PMs...
December 31, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28047031/th-ef-207a-06-high-resolution-optical-ct-ect-imaging-of-unstained-mice-femur-brain-spleen-and-tumor
#13
S Yoon, M Boss, S Birer, M Dewhirst, M Oldham
PURPOSE: Optical transmission and emission computed tomography (optical-CT/ECT) provides high-resolution 3D attenuation and emission maps in unsectioned large (∼1cm(3) ) ex vivo tissue samples at a resolution of 12.9µm(3) per voxel. Here we apply optical-CT/ECT to investigate high-resolution structure and auto-fluorescence in a range of optically cleared mice organs, including, for the first time, mouse bone (femur), opening the potential for study of bone metastasis and bone-mediated immune response...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046845/su-g-iep4-08-initial-investigations-of-up-converting-nanoparticles-ucnp-for-3d-tissue-imaging-in-optical-ect
#14
S Yoon, B Langloss, M Boss, S Birer, M Dewhirst, M Oldham
PURPOSE: Near-IR absorptive up-converting nanoparticles (UCNPs) is a novel contrast for optical-ECT that allows auto-fluorescence-free 3D imaging of labeled cells in a matrix of large (∼1cm(3) ) unsectioned normal tissue. This has the potential to image small metastases or dormant cells that is difficult with down-converting fluorescing dyes due to auto-fluorescence. The feasibility of imaging UCNP in agarose phantoms and a mouse lung is demonstrated, aided by a 3D-printed optical-ECT stage designed to excite UCNP in a mouse lung...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046212/su-f-t-677-synergistic-effect-s-of-clotrimazole-on-radiation-cell-survival-of-a549-lung-cancer-cells-in-glucose-vs-galactose-media
#15
G Boss, M Tambasco, M Garakani
PURPOSE: In order to determine the synergistic effect of clotrimazole on radiosensitivity of A549 lung cancer cells, and the effect of oxidative pathways on modulating radiosensitivity, we studied how these cells survived under varying amounts of radiation and clotrimazole as well ass when glucose was switched for galactose media. METHODS: The glucose media was used to determine the presence of any synergistic effect of clotrimazole on radiation using values of radiation and clotrimazole concentrations, varying from 0 - 8 Gy and 0 - 20 µM, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045997/loss-of-boss-causes-shortened-lifespan-with-mitochondrial-dysfunction-in-drosophila
#16
Ayako Kohyama-Koganeya, Mizuki Kurosawa, Yoshio Hirabayashi
Aging is a universal process that causes deterioration in biological functions of an organism over its lifetime. There are many risk factors that are thought to contribute to aging rate, with disruption of metabolic homeostasis being one of the main factors that accelerates aging. Previously, we identified a new function for the putative G-protein-coupled receptor, Bride of sevenless (BOSS), in energy metabolism. Since maintaining metabolic homeostasis is a critical factor in aging, we investigated whether BOSS plays a role in the aging process...
2017: PloS One
https://www.readbyqxmd.com/read/28041825/sodium-nitrite-and-sodium-thiosulfate-are-effective-against-acute-cyanide-poisoning-when-administered-by-intramuscular-injection
#17
Vikhyat S Bebarta, Matthew Brittain, Adriano Chan, Norma Garrett, David Yoon, Tanya Burney, David Mukai, Michael Babin, Renate B Pilz, Sari B Mahon, Matthew Brenner, Gerry R Boss
STUDY OBJECTIVE: The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection would be preferred. The purpose of this study is to determine whether sodium nitrite and sodium thiosulfate are effective cyanide antidotes when administered by intramuscular injection. METHODS: We used a randomized, nonblinded, parallel-group study design in 3 mammalian models: cyanide gas inhalation in mice, with treatment postexposure; intravenous sodium cyanide infusion in rabbits, with severe hypotension as the trigger for treatment; and intravenous potassium cyanide infusion in pigs, with apnea as the trigger for treatment...
December 29, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28039405/role-of-baff-in-pulmonary-autoantibody-responses-induced-by-chronic-cigarette-smoke-exposure-in-mice
#18
Mathieu C Morissette, Yang Gao, Pamela Shen, Danya Thayaparan, Jean-Christophe Bérubé, Peter D Paré, Corry-Anke Brandsma, Ke Hao, Yohan Bossé, Rachel Ettinger, Ronald Herbst, Alison A Humbles, Roland Kolbeck, Nanshan Zhong, Rongchang Chen, Martin R Stämpfli
Emerging evidence suggests that autoimmune processes are implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). In this study, we assessed the expression of B-cell activating factor (BAFF) in smokers, and investigated the functional importance of BAFF in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies (ANA) and tertiary lymphoid tissues (TLTs) using a preclinical mouse model. We observed that BAFF levels were elevated in smokers and mice exposed to cigarette smoke...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/28029317/laparoscopy-to-predict-the-result-of-primary-cytoreductive-surgery-in-patients-with-advanced-ovarian-cancer-a-randomized-controlled-trial
#19
Marianne J Rutten, Hannah S van Meurs, Roelien van de Vrie, Katja N Gaarenstroom, Christiana A Naaktgeboren, Toon van Gorp, Henk G Ter Brugge, Ward Hofhuis, Henk W R Schreuder, Henriette J G Arts, Petra L M Zusterzeel, Johanna M A Pijnenborg, Maarten van Haaften, Guus Fons, Mirjam J A Engelen, Erik A Boss, M Caroline Vos, Kees G Gerestein, Eltjo M J Schutter, Brent C Opmeer, Anje M Spijkerboer, Patrick M M Bossuyt, Ben Willem Mol, Gemma G Kenter, Marrije R Buist
Purpose To investigate whether initial diagnostic laparoscopy can prevent futile primary cytoreductive surgery (PCS) by identifying patients with advanced-stage ovarian cancer in whom > 1 cm of residual disease will be left after PCS. Patients and Methods This multicenter, randomized controlled trial was undertaken within eight gynecologic cancer centers in the Netherlands. Patients with suspected advanced-stage ovarian cancer who qualified for PCS were eligible. Participating patients were randomly assigned to either laparoscopy or PCS...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28017974/expectations-for-endoscopic-training-during-gynaecological-specialty-training-results-of-a-germany-wide-survey
#20
L Gabriel, E Solomayer, S Schott, A von Heesen, J Radosa, D Wallwiener, S Rimbach, I Juhasz-Böss
Question: Endoscopy is an integral part of surgical gynaecology and is playing an increasingly important role in ensuring adequate gynaecological training in the context of specialty training in general. At present, little is known about the expectations and notions of young junior doctors with respect to endoscopic training. For this reason, junior doctors throughout Germany were surveyed on this topic and asked to share their opinions. Methods: Using an anonymized standardized survey, the following information was elicited: importance of endoscopic training, willingness to take courses, expectations for instructors and the hospital, ideas about the number of required operations, both as a surgical assistant and as a surgeon, as well as satisfaction with the current status of training...
December 2016: Geburtshilfe und Frauenheilkunde
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