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https://www.readbyqxmd.com/read/29137201/review-on-sers-of-bacteria
#1
REVIEW
Pamela A Mosier-Boss
Surface enhanced Raman spectroscopy (SERS) has been widely used for chemical detection. Moreover, the inherent richness of the spectral data has made SERS attractive for use in detecting biological materials, including bacteria. This review discusses methods that have been used to obtain SERS spectra of bacteria. The kinds of SERS substrates employed to obtain SERS spectra are discussed as well as how bacteria interact with silver and gold nanoparticles. The roll of capping agents on Ag/Au NPs in obtaining SERS spectra is examined as well as the interpretation of the spectral data...
November 13, 2017: Biosensors
https://www.readbyqxmd.com/read/29134189/toward-uniform-implementation-of-parametric-map-digital-imaging-and-communication-in-medicine-standard-in-multisite-quantitative-diffusion-imaging-studies
#2
Dariya Malyarenko, Andriy Fedorov, Laura Bell, Melissa Prah, Stefanie Hectors, Lori Arlinghaus, Mark Muzi, Meiyappan Solaiyappan, Michael Jacobs, Maggie Fung, Amita Shukla-Dave, Kevin McManus, Michael Boss, Bachir Taouli, Thomas E Yankeelov, Christopher Chad Quarles, Kathleen Schmainda, Thomas L Chenevert, David C Newitt
This paper reports on results of a multisite collaborative project launched by the MRI subgroup of Quantitative Imaging Network to assess current capability and provide future guidelines for generating a standard parametric diffusion map Digital Imaging and Communication in Medicine (DICOM) in clinical trials that utilize quantitative diffusion-weighted imaging (DWI). Participating sites used a multivendor DWI DICOM dataset of a single phantom to generate parametric maps (PMs) of the apparent diffusion coefficient (ADC) based on two models...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29122004/identification-and-characterization-of-serovar-independent-immunogens-in-actinobacillus-pleuropneumoniae
#3
Fabio Antenucci, Cyrielle Fougeroux, Janine T Bossé, Zofia Magnowska, Camille Roesch, Paul Langford, Peter Johannes Holst, Anders Miki Bojesen
Despite numerous actions to prevent disease, Actinobacillus pleuropneumoniae (A. pleuropneumoniae) remains a major cause of porcine pleuropneumonia, resulting in economic losses to the swine industry worldwide. In this paper, we describe the utilization of a reverse vaccinology approach for the selection and in vitro testing of serovar-independent A. pleuropneumoniae immunogens. Potential immunogens were identified in the complete genomes of three A. pleuropneumoniae strains belonging to different serovars using the following parameters: predicted outer-membrane subcellular localization; ≤ 1 trans-membrane helices; presence of a signal peptide in the protein sequence; presence in all known A...
November 9, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29121877/a-systematic-survey-to-identify-lethal-recessive-variation-in-highly-managed-pig-populations
#4
Martijn F L Derks, Hendrik-Jan Megens, Mirte Bosse, Marcos S Lopes, Barbara Harlizius, Martien A M Groenen
BACKGROUND: Lethal recessive variation can cause prenatal death of homozygous offspring. Although usually present at low-frequency in populations, the impact on individual fitness can be substantial. Until recently, the presence of recessive embryonic lethal variation could only be measured indirectly through reduced fertility. In this study, we estimate the presence of genetic loci associated with both early and late termination of development during gestation in pigs from the wealth of genome data routinely generated by a commercial breeding company...
November 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29116507/construction-and-selection-of-affilin-%C3%A2-phage-display-libraries
#5
Florian Settele, Madlen Zwarg, Sebastian Fiedler, Daniel Koscheinz, Eva Bosse-Doenecke
Affilin(®) molecules represent a new class of so-called scaffold proteins. The concept of scaffold proteins is to use stable and versatile protein structures which can be endowed with de novo binding properties and specificities by introducing mutations in surface exposed amino acid residues. Complex variations and combinations are generated by genetic methods of randomization resulting in large cDNA libraries. The selection for candidates binding to a desired target can be executed by display methods, especially the very robust and flexible phage display...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29112516/intravoxel-incoherent-motion-analysis-of-abdominal-organs-application-of-simultaneous-multislice-acquisition
#6
Valerie Doan Phi Van, Anton S Becker, Alexander Ciritsis, Caecilia S Reiner, Andreas Boss
PURPOSE: The aim of this study was to systematically evaluate the accuracy of quantitative intravoxel incoherent motion (IVIM) analysis of the upper abdomen applying simultaneous multislice (SMS) diffusion-weighted imaging (DWI) to reduce acquisition time. MATERIALS AND METHODS: Diffusion-weighted imaging of parenchymal abdominal organs was performed in 8 healthy volunteers at 3 T using a standard DWI sequence (acceleration factor 1 [AF1]) and an SMS-accelerated echo planar imaging sequence with acceleration factors 2 and 3 (AF2/AF3)...
November 6, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29105178/is-there-evidence-for-more-than-two-diffusion-components-in-abdominal-organs-a-magnetic-resonance-imaging-study-in-healthy-volunteers
#7
Moritz C Wurnig, Manon Germann, Andreas Boss
The most commonly applied model for the description of diffusion-weighted imaging (DWI) data in perfused organs is bicompartmental intravoxel incoherent motion (IVIM) analysis. In this study, we assessed the ground truth of underlying diffusion components in healthy abdominal organs using an extensive DWI protocol and subsequent computation of apparent diffusion coefficient 'spectra', similar to the computation of previously described T2 relaxation spectra. Diffusion datasets of eight healthy subjects were acquired in a 3-T magnetic resonance scanner using 68 different b values during free breathing (equidistantly placed in the range 0-1005 s/mm(2) )...
November 3, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29092993/the-effect-of-a-single-early-high-dose-vitamin-d-supplement-on-fracture-union-in-patients-with-hypovitaminosis-d-a-prospective-randomised-trial
#8
N Haines, L B Kempton, R B Seymour, M J Bosse, C Churchill, K Hand, J R Hsu, D Keil, J Kellam, N Rozario, S Sims, M A Karunakar
AIMS: To evaluate the effect of a single early high-dose vitamin D supplement on fracture union in patients with hypovitaminosis D and a long bone fracture. PATIENTS AND METHODS: Between July 2011 and August 2013, 113 adults with a long bone fracture were enrolled in a prospective randomised double-blind placebo-controlled trial. Their serum vitamin D levels were measured and a total of 100 patients were found to be vitamin D deficient (< 20 ng/ml) or insufficient (< 30 ng/mL)...
November 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29092026/copd-gwas-variant-at-19q13-2-in-relation-with-dna-methylation-and-gene-expression
#9
Ivana Nedeljkovic, Lies Lahousse, Elena Carnero Montoro, Alen Faiz, Judith M Vonk, Kim de Jong, Diana A van der Plaat, Cleo C van Diemen, Maarten van den Berge, Ma'en Obeidat, Yohan Bossé, David C Nickle, Andre G Uitterlinden, Joyce B J van Meurs, Bruno H C Stricker, Guy G Brusselle, Dirkje S Postma, H Marike Boezen, Cornelia M van Duijn, Najaf Amin
Chronic obstructive pulmonary disease (COPD) is among the major health burdens in adults. While cigarette smoking is the leading risk factor, a growing number of genetic variations have been discovered to influence disease susceptibility. Epigenetic modifications may mediate the response of the genome to smoking and regulate gene expression. Chromosome 19q13.2 region is associated with both smoking and COPD, yet its functional role is unclear. Our study aimed to determine whether rs7937 (RAB4B, EGLN2), a top genetic variant in 19q13...
October 28, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29084332/assessment-of-neurotrophins-and-inflammatory-mediators-in-vitreous-of-patients-with-diabetic-retinopathy
#10
Joseph D Boss, Pawan Kumar Singh, Hemang K Pandya, Joaquin Tosi, Chaesik Kim, Asheesh Tewari, Mark S Juzych, Gary W Abrams, Ashok Kumar
Purpose: To assess vitreous levels of inflammatory cytokines and neurotrophins (NTs) in diabetic retinopathy (DR) and elucidate their potential roles. Methods: A prospective study was performed on 50 vitreous samples obtained from patients with DR (n = 22) and the nondiabetic controls (n = 28). All patients were candidates for vitrectomy. Inflammatory cytokine and NT levels were determined with ELISA. Potential source and role of NTs was determined by using human retinal Müller glia and mouse photoreceptor cells and challenging them with TNF-α or IL-1β, followed by detection of NTs and cell death...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29083117/update-on-actinobacillus-pleuropneumoniae-knowledge-gaps-and-challenges
#11
E L Sassu, J T Bossé, T J Tobias, M Gottschalk, P R Langford, I Hennig-Pauka
Porcine pleuropneumonia, caused by the bacterial porcine respiratory tract pathogen Actinobacillus pleuropneumoniae, leads to high economic losses in affected swine herds in most countries of the world. Pigs affected by peracute and acute disease suffer from severe respiratory distress with high lethality. The agent was first described in 1957 and, since then, knowledge about the pathogen itself, and its interactions with the host, has increased continuously. This is, in part, due to the fact that experimental infections can be studied in the natural host...
October 30, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29083101/quantitative-magnetic-resonance-imaging-phantoms-a-review-and-the-need-for-a-system-phantom
#12
REVIEW
Kathryn E Keenan, Maureen Ainslie, Alex J Barker, Michael A Boss, Kim M Cecil, Cecil Charles, Thomas L Chenevert, Larry Clarke, Jeffrey L Evelhoch, Paul Finn, Daniel Gembris, Jeffrey L Gunter, Derek L G Hill, Clifford R Jack, Edward F Jackson, Guoying Liu, Stephen E Russek, Samir D Sharma, Michael Steckner, Karl F Stupic, Joshua D Trzasko, Chun Yuan, Jie Zheng
The MRI community is using quantitative mapping techniques to complement qualitative imaging. For quantitative imaging to reach its full potential, it is necessary to analyze measurements across systems and longitudinally. Clinical use of quantitative imaging can be facilitated through adoption and use of a standard system phantom, a calibration/standard reference object, to assess the performance of an MRI machine. The International Society of Magnetic Resonance in Medicine AdHoc Committee on Standards for Quantitative Magnetic Resonance was established in February 2007 to facilitate the expansion of MRI as a mainstream modality for multi-institutional measurements, including, among other things, multicenter trials...
October 30, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29081261/stem-cell-mobilization-in-poor-mobilizers-with-multiple-myeloma-or-lymphoma-before-and-after-introduction-of-plerixafor-a-single-center-comparative-analysis-using-a-cost-efficient-single-fixed-dose-schedule
#13
Christine Greil, Gabriele Ihorst, Chrissoula Kiote-Schmidt, Steffi Hildenbeutel, Katja Kühbach, Roland Bosse, Justus Duyster, Monika Engelhardt, Ralph Wäsch
No abstract text is available yet for this article.
October 30, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29076625/the-radical-sam-enzyme-nirj-catalyzes-the-removal-of-two-propionate-side-chains-during-heme-d1-biosynthesis
#14
Linda Boss, Ramona Oehme, Susan Billig, Claudia Birkemeyer, Gunhild Layer
Heme d1 is a modified tetrapyrrole playing an important role for denitrification by acting as the catalytically essential cofactor in the cytochrome cd1 nitrite reductase of many denitrifying bacteria. In the course of heme d1 biosynthesis, the two propionate side chains on pyrrole rings A and B of the intermediate 12,18-didecarboxysiroheme are removed from the tetrapyrrole macrocycle. In the final heme d1 molecule, the propionate groups are replaced by two keto functions. Although it was speculated that the Radical SAM enzyme NirJ might be responsible for the removal of the propionate groups and introduction of the keto functions, this has not been shown experimentally, so far...
October 27, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29070878/the-j-curve-association-between-systolic-blood-pressure-and-clinical-outcomes-in-ischemic-stroke-or-tia-the-boss-study
#15
Xuewei Xie, Jie Xu, Hongqiu Gu, Yongli Tao, Pan Chen, Yilong Wang, Yongjun Wang
We aimed to assess the association between systolic blood pressure (SBP) and clinical outcome in 2,397 ischemic stroke (IS) or transient ischemic attack (TIA) patients from the Blood Pressure and Clinical Outcome in TIA or Ischemic Stroke (BOSS) study. BOSS study was a hospital-based, prospective cohort study. The SBP was defined as mean value of 90 days self-measured SBP after onset. Cox proportional hazards models were conducted to test the risk of combined vascular events (CVE) and stroke recurrence among different SBP categories...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29070412/the-screening-compound-collection-a-key-asset-for-drug-discovery
#16
Christoph Boss, Julien Hazemann, Thierry Kimmerlin, Modest von Korff, Urs Lüthi, Oliver Peter, Thomas Sander, Romain Siegrist
In this case study on an essential instrument of modern drug discovery, we summarize our successful efforts in the last four years toward enhancing the Actelion screening compound collection. A key organizational step was the establishment of the Compound Library Committee (CLC) in September 2013. This cross-functional team consisting of computational scientists, medicinal chemists and a biologist was endowed with a significant annual budget for regular new compound purchases. Based on an initial library analysis performed in 2013, the CLC developed a New Library Strategy...
October 25, 2017: Chimia
https://www.readbyqxmd.com/read/29066090/genetic-variants-associated-with-susceptibility-to-idiopathic-pulmonary-fibrosis-in-people-of-european-ancestry-a-genome-wide-association-study
#17
Richard J Allen, Joanne Porte, Rebecca Braybrooke, Carlos Flores, Tasha E Fingerlin, Justin M Oldham, Beatriz Guillen-Guio, Shwu-Fan Ma, Tsukasa Okamoto, Alison E John, Ma'en Obeidat, Ivana V Yang, Amanda Henry, Richard B Hubbard, Vidya Navaratnam, Gauri Saini, Norma Thompson, Helen L Booth, Simon P Hart, Mike R Hill, Nik Hirani, Toby M Maher, Robin J McAnulty, Ann B Millar, Philip L Molyneaux, Helen Parfrey, Doris M Rassl, Moira K B Whyte, William A Fahy, Richard P Marshall, Eunice Oballa, Yohan Bossé, David C Nickle, Don D Sin, Wim Timens, Nick Shrine, Ian Sayers, Ian P Hall, Imre Noth, David A Schwartz, Martin D Tobin, Louise V Wain, R Gisli Jenkins
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified a significant genetic risk associated with the development of IPF; however, mechanisms by which genetic risk factors promote IPF remain unclear. We aimed to identify genetic variants associated with IPF susceptibility and provide mechanistic insight using gene and protein expression analyses. METHODS: We used a two-stage approach: a genome-wide association study in patients with IPF of European ancestry recruited from nine different centres in the UK and controls selected from UK Biobank (stage 1) matched for age, sex, and smoking status; and a follow-up of associated genetic variants in independent datasets of patients with IPF and controls from two independent US samples from the Chicago consortium and the Colorado consortium (stage 2)...
November 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29062253/gorlin-goltz-syndrome
#18
Betül Şereflican, Bengü Tuman, Murat Şereflican, Sıddıka Halıcıoğlu, Gülzade Özyalvaçlı, Seval Bayrak
Gorlin-Goltz syndrome is a rare multisystemic disease inherited in an autosomal dominant pattern. It is characterized by numerous basal cell carcinoma of the skin, jaw cysts, and skeletal anomalies such as frontal bossing, vertebral anomalies, palmoplantar pits, and falx cerebri calcification. There is a tendency to tumors including medullablastoma, fibroma, rabdomyoma, leiomyosarcoma etc.. The diagnosis is based on major and minor clinical and radiologic criteria. Early diagnosis and treatment are of utmost importance in reducing the severity of long-term sequelae of this syndrome...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29060870/quality-assessment-of-3d-visualizations-with-vertical-disparity-an-erp-approach
#19
Forooz Shahbazi, Sebastian Bosse, Guido Nolte, Thomas Wiegand, Wojciech Samek
In an objective approach for the assessment of quality of experience the neural correlates of EEG data are studied when stereoscopic images are presented in three different conditions containing vertical disparity. These conditions are compared to a similar image in 2D both on the channel level by studying the ERP components and on the source level by the localization of the corresponding ERP component. Our findings posit that P1 component in the occipital cortex has significantly increased in amplitude for 3D condition without vertical disparity compared to the 2D condition...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054068/quantitative-determination-of-additive-chlorantraniliprole-in-abamectin-preparation-investigation-of-bootstrapping-soft-shrinkage-approach-by-mid-infrared-spectroscopy
#20
Hong Yan, Xiangzhong Song, Kuangda Tian, Yilin Chen, Yanmei Xiong, Shungeng Min
A novel method, mid-infrared (MIR) spectroscopy, which enables the determination of Chlorantraniliprole in Abamectin within minutes, is proposed. We further evaluate the prediction ability of four wavelength selection methods, including bootstrapping soft shrinkage approach (BOSS), Monte Carlo uninformative variable elimination (MCUVE), genetic algorithm partial least squares (GA-PLS) and competitive adaptive reweighted sampling (CARS) respectively. The results showed that BOSS method obtained the lowest root mean squared error of cross validation (RMSECV) (0...
September 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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