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Jamie A Davies

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https://www.readbyqxmd.com/read/28424332/improving-genetic-diagnosis-in-mendelian-disease-with-transcriptome-sequencing
#1
Beryl B Cummings, Jamie L Marshall, Taru Tukiainen, Monkol Lek, Sandra Donkervoort, A Reghan Foley, Veronique Bolduc, Leigh B Waddell, Sarah A Sandaradura, Gina L O'Grady, Elicia Estrella, Hemakumar M Reddy, Fengmei Zhao, Ben Weisburd, Konrad J Karczewski, Anne H O'Donnell-Luria, Daniel Birnbaum, Anna Sarkozy, Ying Hu, Hernan Gonorazky, Kristl Claeys, Himanshu Joshi, Adam Bournazos, Emily C Oates, Roula Ghaoui, Mark R Davis, Nigel G Laing, Ana Topf, Peter B Kang, Alan H Beggs, Kathryn N North, Volker Straub, James J Dowling, Francesco Muntoni, Nigel F Clarke, Sandra T Cooper, Carsten G Bönnemann, Daniel G MacArthur
Exome and whole-genome sequencing are becoming increasingly routine approaches in Mendelian disease diagnosis. Despite their success, the current diagnostic rate for genomic analyses across a variety of rare diseases is approximately 25 to 50%. We explore the utility of transcriptome sequencing [RNA sequencing (RNA-seq)] as a complementary diagnostic tool in a cohort of 50 patients with genetically undiagnosed rare muscle disorders. We describe an integrated approach to analyze patient muscle RNA-seq, leveraging an analysis framework focused on the detection of transcript-level changes that are unique to the patient compared to more than 180 control skeletal muscle samples...
April 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28407995/impact-of-a-university-based-outpatient-telemedicine-program-on-time-savings-travel-costs-and-environmental-pollutants
#2
Navjit W Dullet, Estella M Geraghty, Taylor Kaufman, Jamie L Kissee, Jesse King, Madan Dharmar, Anthony C Smith, James P Marcin
OBJECTIVE: The objective of this study was to estimate travel-related and environmental savings resulting from the use of telemedicine for outpatient specialty consultations with a university telemedicine program. METHODS: The study was designed to retrospectively analyze the telemedicine consultation database at the University of California Davis Health System (UCDHS) between July 1996 and December 2013. Travel distances and travel times were calculated between the patient home, the telemedicine clinic, and the UCDHS in-person clinic...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28407484/autoreactive-t-cells-and-chronic-fungal-infection-drive-esophageal-carcinogenesis
#3
Feng Zhu, Jami Willette-Brown, Na-Young Song, Dakshayani Lomada, Yongmei Song, Liyan Xue, Zane Gray, Zitong Zhao, Sean R Davis, Zhonghe Sun, Peilin Zhang, Xiaolin Wu, Qimin Zhan, Ellen R Richie, Yinling Hu
Humans with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a T cell-driven autoimmune disease caused by impaired central tolerance, are susceptible to chronic fungal infection and esophageal squamous cell carcinoma (ESCC). However, the relationship between autoreactive T cells and chronic fungal infection in ESCC development remains unclear. We find that kinase-dead Ikkα knockin mice develop APECED-like phenotypes, including impaired central tolerance, autoreactive T cells, chronic fungal infection, and ESCCs expressing specific human ESCC markers...
April 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28403664/milk-options-observation-moo-a-mixed-methods-study-of-chocolate-milk-removal-on-beverage-consumption-and-student-staff-behaviors-in-a-rural-elementary-school
#4
Melinda M Davis, Margaret Spurlock, Katrina Ramsey, Jamie Smith, Beth Ann Beamer, Susan Aromaa, Paul B McGinnis
Providing flavored milk in school lunches is controversial, with conflicting evidence on its impact on nutritional intake versus added sugar consumption and excess weight gain. Nonindustry-sponsored studies using individual-level analyses are needed. Therefore, we conducted this mixed-methods study of flavored milk removal at a rural primary school between May and June 2012. We measured beverage selection/consumption pre- and post-chocolate milk removal and collected observation field notes. We used linear and logistic mixed models to assess beverage waste and identified themes in staff and student reactions...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/28369863/symmetry-breaking-in-branching-epithelia-cells-on-micro-patterns-under-flow-challenge-the-hypothesis-of-positive-feedback-by-a-secreted-autocrine-inhibitor-of-motility
#5
Kimberly C Martin, Xiaofei Yuan, Gregory Stimac, Kieran Bannerman, Jamie Anderson, Chloe Roy, Fokion Glykofrydis, Huabing Yin, Jamie A Davies
Branching morphogenesis of epithelia involves division of cells into leader (tip) and follower (stalk) cells. Published work on cell lines in culture has suggested that symmetry-breaking takes place via a secreted autocrine inhibitor of motility, the inhibitor accumulating more in concave regions of the culture boundary, slowing advance of cells there, and less in convex areas, allowing advance and a further exaggeration of the concave/convex difference. Here we test this hypothesis using a two-dimensional culture system that includes strong flow conditions to remove accumulating diffusible secretions...
March 29, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28351865/using-synthetic-biology-to-explore-principles-of-development
#6
REVIEW
Jamie Davies
Developmental biology is mainly analytical: researchers study embryos, suggest hypotheses and test them through experimental perturbation. From the results of many experiments, the community distils the principles thought to underlie embryogenesis. Verifying these principles, however, is a challenge. One promising approach is to use synthetic biology techniques to engineer simple genetic or cellular systems that follow these principles and to see whether they perform as expected. As I review here, this approach has already been used to test ideas of patterning, differentiation and morphogenesis...
April 1, 2017: Development
https://www.readbyqxmd.com/read/28330751/reduction-in-heart-failure-hospitalizations-with-ambulatory-hemodynamic-monitoring-seen-in-clinical-trials-is-maintained-in-the-real-world
#7
Akshay S Desai, Arvind Bhimaraj, Rupinder Bharmi, Rita Jermyn, Kunjan Bhatt, David Shavelle, Margaret M Redfield, Robert Hull, Jamie A Pelzel, Kevin Davis, Nirav Dalal, Philip B Adamson, J Thomas Heywood
BACKGROUND: In the CHAMPION trial, heart failure hospitalization (HFH) rates were lower in patients managed with guidance from an implantable pulmonary artery pressure (PAP) sensor compared to usual care. OBJECTIVES: To examine the effectiveness of ambulatory hemodynamic monitoring in reducing HFH outside the clinical trial setting. METHODS: We conducted a retrospective cohort study using US Medicare claims data from patients undergoing PAP sensor implantation between 6/1/2014 and 12/31/2015...
March 9, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28286747/rapid-fabrication-of-cell-laden-alginate-hydrogel-3d-structures-by-micro-dip-coating
#8
Atabak Ghanizadeh Tabriz, Christopher G Mills, John J Mullins, Jamie A Davies, Wenmiao Shu
Development of a simple, straightforward 3D fabrication method to culture cells in 3D, without relying on any complex fabrication methods, remains a challenge. In this paper, we describe a new technique that allows fabrication of scalable 3D cell-laden hydrogel structures easily, without complex machinery: the technique can be done using only apparatus already available in a typical cell biology laboratory. The fabrication method involves micro dip-coating of cell-laden hydrogels covering the surface of a metal bar, into the cross-linking reagents calcium chloride or barium chloride to form hollow tubular structures...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28264785/temperament-factors-and-dimensional-latent-bifactor-models-of-child-psychopathology-transdiagnostic-and-specific-associations-in-two-youth-samples
#9
Benjamin L Hankin, Elysia Poggi Davis, Hannah Snyder, Jami F Young, Laura M Glynn, Curt A Sandman
Common emotional and behavioral symptoms co-occur and are associated with core temperament factors. This study investigated links between temperament and dimensional, latent psychopathology factors, including a general common psychopathology factor (p factor) and specific latent internalizing and externalizing liabilities, as captured by a bifactor model, in two independent samples of youth. Specifically, we tested the hypothesis that temperament factors of negative affectivity (NA), positive affectivity (PA), and effortful control (EC) could serve as both transdiagnostic and specific risks in relation to recent bifactor models of child psychopathology...
March 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28251935/dietary-quality-changes-in-response-to-a-sugar-sweetened-beverage-reduction-intervention-results-from-the-talking-health-randomized-controlled-clinical-trial
#10
Valisa E Hedrick, Brenda M Davy, Wen You, Kathleen J Porter, Paul A Estabrooks, Jamie M Zoellner
Background: The reduction of sugar-sweetened beverage (SSB) intake may be beneficial for weight management and other related health conditions; however, to our knowledge, no data exist regarding the spontaneous changes in other dietary components or the overall dietary quality after an SSB-reduction intervention.Objectives: We explored longitudinal changes within and between an SSB-reduction intervention (SIPsmartER) and a physical activity intervention (MoveMore) with respect to spontaneous changes in 1) energy intake and macronutrients and micronutrients, 2) dietary quality [Healthy Eating Index-2010 (HEI)], and 3) beverage categories...
April 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28247538/management-of-pinna-haematoma-study-maphaes-a-multicentre-retrospective-observational-study
#11
A Vijendren, M Coates, M E Smith, O V Ajayi, W Al-Dhahir, J Bewick, P F Bowles, P Coyle, C R Davies-Husband, S E Erskine, E Halliday, A I Kaleva, A Lau, L Langstaff, E Mathew, S Meghji, A I Testera, J R V Thomas, M Eisenhut
OBJECTIVES: To assess current variation in the management of pinna haematoma (PH) and its effect on outcomes. DESIGN: Multicentre retrospective observational record-based study. SETTING: Eleven hospitals around the UK. PARTICIPANTS: Eighty-three patients above the age of 16 with PH. OUTCOME MEASURES: The primary outcome measure was recurrence rate of PH over a 6-month period post-treatment, assessed by treatment type (scalpel incision vs needle aspiration)...
March 1, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28167525/the-history-of-bordetella-pertussis-genome-evolution-includes-structural-rearrangement
#12
Michael R Weigand, Yanhui Peng, Vladimir Loparev, Dhwani Batra, Katherine E Bowden, Mark Burroughs, Pamela K Cassiday, Jamie K Davis, Taccara Johnson, Phalasy Juieng, Kristen Knipe, Marsenia H Mathis, Andrea M Pruitt, Lori Rowe, Mili Sheth, M Lucia Tondella, Margaret M Williams
Despite high pertussis vaccine coverage, reported cases of whooping cough (pertussis) have increased over the last decade in the United States and other developed countries. Although Bordetella pertussis is well known for its limited gene sequence variation, recent advances in long-read sequencing technology have begun to reveal genomic structural heterogeneity among otherwise indistinguishable isolates, even within geographically or temporally defined epidemics. We have compared rearrangements among complete genome assemblies from 257 B...
April 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28166712/experimental-acute-infection-of-alpacas-with-bovine-viral-diarrhea-virus-1-subgenotype-b-alters-peripheral-blood-and-galt-leukocyte-subsets
#13
Christina L Topliff, Abdulrahman A Alkheraif, Charles A Kuszynski, William C Davis, David J Steffen, Jack A Schmitz, Kent M Eskridge, Bryan Charleston, Jamie N Henningson, Clayton L Kelling
Bovine viral diarrhea virus (BVDV) is a pathogen in cattle and alpacas ( Vicugna pacos), causing acute and persistent BVDV infections. We characterized the effect of acute BVDV infection on the immune system of alpacas by determining lymphocyte subpopulations in peripheral blood and gut-associated lymphoid tissues (GALT) as well as serum interferon levels. Alpacas were experimentally infected with BVDV-1b (strain CO-06). Peripheral blood leukocytes were isolated at 0, 3, 6, and 9 d postinfection (dpi), and leukocytes of GALT at 9 dpi, and evaluated using flow cytometry...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28152804/engagement-in-a-statewide-oral-oncolytic-collaborative-and-practice-impact
#14
Emily R Mackler, Grayce Galiyas, Laura Petersen, Jamie Lindsay, Teresa M Salgado, Emily Davis, Karen B Farris
89 Background: The rapid shift to oral oncolytic therapy presents challenges to oncology practitioners. The purpose of this study is to describe how participation in a statewide oral oncolytic improvement collaborative where best practices and resources were shared can readily impact quality of care as measured by national standards. METHODS: The Michigan Oncology Quality Consortium (MOQC) hosted a series of learning collaborative sessions focused on topics and deployment of resources specific to oral oncolytic management and quality improvement...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152281/glutathione-s-transferase-p1-may-predispose-children-to-a-decline-in-pulmonary-function-after-stem-cell-transplant
#15
Julie Stark, Jamie Renbarger, James Slaven, Zhangsheng Yu, Jenny Then, Jodi Skiles, Stephanie Davis
RATIONALE: Pulmonary complications after hematopoietic stem cell transplant (SCT) are associated with increased mortality. Genetic markers for those at risk for pulmonary impairment post-SCT have not been widely investigated. METHODS: Forty-nine patients were retrospectively selected from a single institution's biorepository with linked clinical data. All subjects performed pre-SCT PFTs. Genotyping was conducted using the Infinium Exome-24 BeadChip. Four single nucleotide polymorphisms (SNPs) were selected (rs1800871, rs1695, rs1800629, rs12477314) and evaluated for association with PFT parameters as change over time from baseline...
February 2, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28025538/the-impact-of-health-literacy-status-on-the-comparative-validity-and-sensitivity-of-an-interactive-multimedia-beverage-intake-questionnaire
#16
Lucy P Hooper, Emily A Myers, Jamie M Zoellner, Brenda M Davy, Valisa E Hedrick
Self-reported dietary assessment methods can be challenging to validate, and reporting errors for those with lower health literacy (HL) may be augmented. Interactive multimedia (IMM) based questionnaires could help overcome these limitations. The objectives of this investigation are to assess the comparative validity and sensitivity to change of an IMM beverage intake questionnaire (IMM-BEVQ) as compared to dietary recalls and determine the impact of HL. Adults completed three 24-h dietary recalls and the IMM-BEVQ at baseline and after a six-month intervention targeting either sugar-sweetened beverages (SSB) or physical activity...
December 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27999580/methodology-for-high-throughput-field-phenotyping-of-canopy-temperature-using-airborne-thermography
#17
David M Deery, Greg J Rebetzke, Jose A Jimenez-Berni, Richard A James, Anthony G Condon, William D Bovill, Paul Hutchinson, Jamie Scarrow, Robert Davy, Robert T Furbank
Lower canopy temperature (CT), resulting from increased stomatal conductance, has been associated with increased yield in wheat. Historically, CT has been measured with hand-held infrared thermometers. Using the hand-held CT method on large field trials is problematic, mostly because measurements are confounded by temporal weather changes during the time required to measure all plots. The hand-held CT method is laborious and yet the resulting heritability low, thereby reducing confidence in selection in large scale breeding endeavors...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27977223/randomized-controlled-trial-to-dismantle-exposure-relaxation-and-rescripting-therapy-errt-for-trauma-related-nightmares
#18
Kristi E Pruiksma, Christopher C Cranston, Jamie L Rhudy, Rachel L Micol, Joanne L Davis
OBJECTIVE: The aim of this study was to conduct a preliminary dismantling study of exposure, relaxation, and rescripting therapy (ERRT) for nightmares. METHOD: Participants (N = 70) were randomized to 1 of 2 conditions: ERRT with nightmare exposure and rescripting (full protocol; EX) or ERRT without nightmare exposure and rescripting (NEX). Participants completed follow-ups at 1 week, 3 months, and 6 months posttreatment. RESULTS: Both conditions yielded statistically significant improvements with medium to large effect sizes on primary outcomes related to nightmares (i...
December 15, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27959936/a-low-dose-of-dietary-quercetin-fails-to-protect-against-the-development-of-an-obese-phenotype-in-mice
#19
Reilly T Enos, Kandy T Velázquez, Meredith S Carson, Jamie L McClellan, Prakash Nagarkatti, Mitzi Nagarkatti, J Mark Davis, E Angela Murphy
The purpose of this study was to examine the effect of a 40% high-fat diet (HFD) supplemented with a dietary attainable level of quercetin (0.02%) on body composition, adipose tissue (AT) inflammation, Non-Alcoholic Fatty-Liver Disease (NAFLD), and metabolic outcomes. Diets were administered for 16 weeks to C57BL/6J mice (n = 10/group) beginning at 4 weeks of age. Body composition and fasting blood glucose, insulin, and total cholesterol concentrations were examined intermittently. AT and liver mRNA expression (RT-PCR) of inflammatory mediators (F4/80, CD206 (AT only), CD11c (AT only) TLR-2 (AT only), TLR-4 (AT only), MCP-1, TNF-α, IL-6 (AT only), and IL-10 (AT only)) were measured along with activation of NFκB-p65, and JNK (western blot)...
2016: PloS One
https://www.readbyqxmd.com/read/27898211/response-to-lu-et-al-re-identifying-underlying-emotional-instability-and-utilizing-a-combined-intervention-in-the-treatment-of-childhood-constipation-and-encopresis-a-case-report
#20
COMMENT
Jamie L Davis
No abstract text is available yet for this article.
December 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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