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https://www.readbyqxmd.com/read/27832807/sex-specific-variation-in-signaling-pathways-and-gene-expression-patterns-in-human-leukocytes-in-response-to-endotoxin-and-exercise
#1
Asghar Abbasi, Rodolfo de Paula Vieira, Felix Bischof, Michael Walter, Masoud Movassaghi, Nicole C Berchtold, Andreas M Niess, Carl W Cotman, Hinnak Northoff
BACKGROUND: While exercise effects on the immune system have received increasing attention in recent years, it remains unclear to what extent gender and fluctuations in sex hormones during menstrual cycle influence immunological responses to exercise. METHODS: We investigated mRNA changes induced through exhaustive exercise (half-marathon; pre-exercise and post-exercise [30 min, 3 h, 24 h] on whole blood cultures ± lipopolysaccharide [LPS] [1 h]) with a specific focus on sex differences (men vs women in luteal phase) as an extension of our previous study...
November 10, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27829437/in-vivo-inhibition-of-mir-155-significantly-alters-post-stroke-inflammatory-response
#2
Juan Carlos Pena-Philippides, Ernesto Caballero-Garrido, Tamar Lordkipanidze, Tamara Roitbak
BACKGROUND: MicroRNA miR-155 is implicated in modulation of the inflammatory processes in various pathological conditions. In our previous studies, we demonstrated that in vivo inhibition of miR-155 promotes functional recovery after mouse experimental stroke. In the present study, we explored if this beneficial effect is associated with miR-155 inhibition-induced alterations in post-stroke inflammatory response. METHODS: Intravenous injections of a specific miR-155 inhibitor were initiated at 48 h after mouse distal middle cerebral artery occlusion (dMCAO)...
November 9, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27698747/co-expressed-differentially-expressed-genes-and-long-non-coding-rnas-involved-in-the-celecoxib-treatment-of-gastric-cancer-an-rna-sequencing-analysis
#3
Bin Song, Juan Du, Ye Feng, Yong-Jian Gao, Ji-Sheng Zhao
The aim of the present study was to investigate the mechanisms of long non-coding RNAs (lncRNAs) in a gastric cancer cell line treated with celecoxib. The human gastric carcinoma cell line NCI-N87 was treated with 15 µM celecoxib for 72 h (celecoxib group) and an equal volume of dimethylsulfoxide (control group), respectively. Libraries were constructed by NEBNext Ultra RNA Library Prep kit for Illumina. Paired-end RNA sequencing reads were aligned to a human hg19 reference genome using TopHat2. Differentially expressed genes (DEGs) and lncRNAs were identified using Cuffdiff...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27682863/chemokine-cxcl1-may-serve-as-a-potential-molecular-target-for-hepatocellular-carcinoma
#4
Ke-Qi Han, Hui Han, Xue-Qun He, Lei Wang, Xiao-Dong Guo, Xue-Ming Zhang, Jie Chen, Quan-Gang Zhu, Hua Nian, Xiao-Feng Zhai, Ma-Wei Jiang
The purpose of this study was to screen for changes in chemokine and chemokine-related genes that are expressed in hepatocellular carcinoma (HCC) as potential markers of HCC progression. Total RNA was extracted from tumor and peritumor tissues from mice with HCC and analyzed using a PCR microarray comprising 98 genes. Changes in gene expression of threefold or more were screened and subsequently confirmed by immunohistochemical analyses and western blotting. Furthermore, whether chemokine knockdown by RNA interference (RNAi) could significantly suppress tumor growth in vivo was also evaluated...
September 28, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27512010/cxcl3-positively-regulates-adipogenic-differentiation
#5
Joji Kusuyama, Anna Komorizono, Kenjiro Bandow, Tomokazu Ohnishi, Tetsuya Matsuguchi
Chemokines are a family of cytokines inducing cell migration and inflammation. Recent reports have implicated the roles of chemokines in cell differentiation. However, little is known about the functional roles of chemokines in adipocytes. Here, we explored gene expression levels of chemokines and chemokine receptors during adipogenic differentiation. We have found that two chemokines, chemokine (C-X-C motif) ligand 3 (CXCL3) and CXCL13, as well as CXC chemokine receptor 2 (CXCR2), a CXCL3 receptor, are highly expressed in mature adipocytes...
October 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27493972/actions-of-thyroid-hormone-analogues-on-chemokines
#6
REVIEW
Paul J Davis, Gennadi V Glinsky, Hung-Yun Lin, Shaker A Mousa
The extracellular domain of plasma membrane integrin αvβ3 contains a receptor for thyroid hormone (L-thyroxine, T4; 3,5,3'-triiodo-L-thyronine, T3); this receptor also binds tetraiodothyroacetic acid (tetrac), a derivative of T4. Tetrac inhibits the binding of T4 and T3 to the integrin. Fractalkine (CX3CL1) is a chemokine relevant to inflammatory processes in the CNS that are microglia-dependent but also important to normal brain development. Expression of the CX3CL1 gene is downregulated by tetrac, suggesting that T4 and T3 may stimulate fractalkine expression...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27330034/the-epithelial-cell-response-to-health-and-disease-associated-oral-biofilm-models
#7
G Ramage, D F Lappin, E Millhouse, J Malcolm, A Jose, J Yang, D J Bradshaw, J R Pratten, S Culshaw
BACKGROUND AND OBJECTIVE: Different bacteria differentially stimulate epithelial cells. Biofilm composition and viability are likely to influence the epithelial response. In vitro model systems are commonly used to investigate periodontitis-associated bacteria and their interactions with the host; therefore, understanding factors that influence biofilm-cell interactions is essential. The present study aimed to develop in vitro monospecies and multispecies biofilms and investigate the epithelial response to these biofilms...
June 22, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27255419/cxcl3-contributes-to-cd133-cscs-maintenance-and-forms-a-positive-feedback-regulation-loop-with-cd133-in-hcc-via-erk1-2-phosphorylation
#8
Lin Zhang, Lixing Zhang, Hong Li, Chao Ge, Fangyu Zhao, Hua Tian, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li
Although the chemotactic cytokine CXCL3 is thought to play an important role in tumor initiation and invasion, little is known about its function in hepatocellular carcinoma (HCC). In our previous study, we found that Ikaros inhibited CD133 expression via the MAPK pathway in HCC. Here, we showed that Ikaros may indirectly down-regulate CXCL3 expression in HCC cells, which leads to better outcomes in patients with CD133(+) cancer stem cell (CSC) populations. CD133 overexpression induced CXCL3 expression, and silencing of CD133 down-regulated CXCL3 in HCC cells...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27183578/hemocyanins-stimulate-innate-immunity-by-inducing-different-temporal-patterns-of-proinflammatory-cytokine-expression-in-macrophages
#9
Ta-Ying Zhong, Sergio Arancibia, Raimundo Born, Ricardo Tampe, Javiera Villar, Miguel Del Campo, Augusto Manubens, María Inés Becker
Hemocyanins induce a potent Th1-dominant immune response with beneficial clinical outcomes when used as a carrier/adjuvant in vaccines and nonspecific immunostimulant in cancer. However, the mechanisms by which hemocyanins trigger innate immune responses, leading to beneficial adaptive immune responses, are unknown. This response is triggered by a proinflammatory signal from various components, of which macrophages are an essential part. To understand how these proteins influence macrophage response, we investigated the effects of mollusks hemocyanins with varying structural and immunological properties, including hemocyanins from Concholepas concholepas, Fissurella latimarginata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal macrophages...
June 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27163710/hiv-infection-induced-transcriptional-program-in-renal-tubular-epithelial-cells-activates-a-cxcr2-driven-cd4-t-cell-chemotactic-response
#10
Ping Chen, Zhengzi Yi, Weijia Zhang, Mary E Klotman, Benjamin K Chen
OBJECTIVE: Viral replication and interstitial inflammation play important roles in the pathogenesis of HIV-associated nephropathy. Cell-cell interactions between renal tubule epithelial cells (RTECs) and HIV-infected T cells can trigger efficient virus internalization and viral gene expression by RTEC. To understand how HIV replication initiates HIV-associated nephropathy, we studied the cellular response of RTECs to HIV, examining the transcriptional profiles of primary RTECs exposed to cell-free HIV or HIV-infected T cells...
July 31, 2016: AIDS
https://www.readbyqxmd.com/read/27122058/oncostatin-m-overexpression-induces-skin-inflammation-but-is-not-required-in-the-mouse-model-of-imiquimod-induced-psoriasis-like-inflammation
#11
Mathilde Pohin, William Guesdon, Adela Andrine Tagne Mekouo, Hanitriniaina Rabeony, Isabelle Paris, Hristo Atanassov, Laure Favot, Jiad Mcheik, François-Xavier Bernard, Carl D Richards, Jérôme Amiaud, Frédéric Blanchard, Jean-Claude Lecron, Franck Morel, Jean-François Jégou
Oncostatin M (OSM) has been reported to be overexpressed in psoriasis skin lesions and to exert proinflammatory effects in vitro on human keratinocytes. Here, we report the proinflammatory role of OSM in vivo in a mouse model of skin inflammation induced by intradermal injection of murine OSM-encoding adenovirus (AdOSM) and compare with that induced by IL-6 injection. Here, we show that OSM potently regulates the expression of genes involved in skin inflammation and epidermal differentiation in murine primary keratinocytes...
July 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/26934137/natural-killer-t-cells-contribute-to-neutrophil-recruitment-and-ocular-tissue-damage-in-a-model-of-intraocular-tumor-rejection
#12
Ann J Ligocki, Jerry Y Niederkorn
PURPOSE: Immune privilege of the eye protects the nonregenerative ocular tissues from innate and adaptive immune-mediated inflammation. In the case of intraocular tumors, immune privilege can be arrested to allow for immune-mediated rejection. Activation of innate immune cells can contribute to necrosis of the intraocular tumor and bystander ocular tissue. Identifying the cellular components of the innate immune system that contribute to ocular destruction, but are not needed for tumor rejection, provides insights into the immunopathological sequelae in intraocular tumor rejection...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26862745/transgenic-overexpression-of-aryl-hydrocarbon-receptor-repressor-ahrr-and-ahr-mediated-induction-of-cyp1a1-cytokines-and-acute-toxicity
#13
Christoph F A Vogel, W L William Chang, Sarah Kado, Kelly McCulloh, Helena Vogel, Dalei Wu, Thomas Haarmann-Stemmann, GuoXiang Yang, Patrick S C Leung, Fumio Matsumura, M Eric Gershwin
BACKGROUND: The aryl hydrocarbon receptor repressor (AhRR) is known to repress aryl hydrocarbon receptor (AhR) signaling, but very little is known regarding the role of the AhRR in vivo. OBJECTIVE: This study tested the role of AhRR in vivo in AhRR overexpressing mice on molecular and toxic end points mediated through a prototypical AhR ligand. METHODS: We generated AhRR-transgenic mice (AhRR Tg) based on the genetic background of C57BL/6J wild type (wt) mice...
July 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/26837773/overexpression-of-cxcl3-can-enhance-the-oncogenic-potential-of-prostate-cancer
#14
Shi-Liang Gui, Li-Chen Teng, Shu-Qiu Wang, Shuang Liu, Ying-Li Lin, Xiao-Lian Zhao, Lei Liu, Hong-Yu Sui, Yang Yang, Li-Chun Liang, Mo-Lin Wang, Xin-Yi Li, Yu Cao, Feng-Ying Li, Wei-Qun Wang
PURPOSE: CXCL3 and its receptor CXCR2 were considered to play particularly important roles in the progression of malignancies. However, the investigations about CXCL3/CXCR2 axis in prostate cancer have been poorly involved. Herein we firstly reported our studies on the expression and biological roles of CXCL3 and CXCR2 in prostate cancer. METHODS: Expression levels of CXCL3 and CXCR2 in prostate cancer cell lines (PC-3, DU145 and LNCaP), immortalized prostate stromal cell line (WPMY-1) and immortalized prostate epithelial cell line (RWPE-1) were investigated by RT-PCR, ELISA and western blot, whereas expression levels of CXCL3 in a prostate tissue microarray were detected by immunohistochemistry...
May 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/26752465/increased-expression-of-interleukin-36-a-member-of-the-interleukin-1-cytokine-family-in-inflammatory-bowel-disease
#15
Atsushi Nishida, Kentaro Hidaka, Toshihiro Kanda, Hirotsugu Imaeda, Makoto Shioya, Osamu Inatomi, Shigeki Bamba, Katsuyuki Kitoh, Mitsushige Sugimoto, Akira Andoh
BACKGROUND: Interleukin (IL)-36 (IL-36α, IL-36β, and IL-36γ) is a recently reported member of the IL-1 cytokine family. In this study, we investigated IL-36 expression in the inflamed mucosa of patients with inflammatory bowel disease and characterized the proinflammatory actions of IL-36 cytokines in human colonic epithelial cells. METHODS: IL-36 mRNA expression was evaluated using real-time PCR. IL-36 protein expression was analyzed using immunoblotting and immunohistochemical technique...
February 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26705326/scleroderma-dermal-microvascular-endothelial-cells-exhibit-defective-response-to-pro-angiogenic-chemokines
#16
Pei-Suen Tsou, Bradley J Rabquer, Ray A Ohara, William A Stinson, Phillip L Campbell, M Asif Amin, Beatrix Balogh, George Zakhem, Paul A Renauer, Ann Lozier, Eshwar Arasu, G Kenneth Haines, Bashar Kahaleh, Elena Schiopu, Dinesh Khanna, Alisa E Koch
OBJECTIVES: Angiogenesis plays a critical role in SSc (scleroderma). The aim of this study was to examine the expression of growth-regulated protein-γ (Gro-γ/CXCL3), granulocyte chemotactic protein 2 (GCP-2/CXCL6) and their receptor CXCR2 in endothelial cells (ECs) isolated from SSc skin and determine whether these cells mount an angiogenic response towards pro-angiogenic chemokines. The downstream signalling pathways as well as the pro-angiogenic transcription factor inhibitor of DNA-binding protein 1 (Id-1) were also examined...
April 2016: Rheumatology
https://www.readbyqxmd.com/read/26657563/clinical-effect-of-cardiac-shock-wave-therapy-on-myocardial-ischemia-in-patients-with-ischemic-heart-failure
#17
Wenxia Wang, Hua Liu, Mengxian Song, Weiyi Fang, Fang Yuan
BACKGROUND: Cardiac shock wave therapy (CSWT) can improve myocardial ischemia and cardiac function in patients with coronary artery disease and refractory angina. The aim of the study was to test its potential role to relieve symptoms in patients with ischemic heart failure (HF) and to identify CSWT-affected genes. METHODS: Cardiac shock wave therapy was performed on 23 patients (mean age: 67 ± 6 years) with ischemic HF 3 times per week for 3 weeks. Clinical assessment parameters were measured for all patients, and peripheral blood mononuclear cells (PBMCs) were isolated from whole blood of all patients 3 days before CSWT and 1 week after the 3-week CSWT schedule...
July 2016: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26472015/epigenetic-characteristics-in-inflammatory-candidate-genes-in-aggressive-periodontitis
#18
Susanne Schulz, Uta Dorothee Immel, Louise Just, Hans-Günter Schaller, Christiane Gläser, Stefan Reichert
BACKGROUND: Periodontitis is a chronic inflammatory disease triggered by the host immune response. Epigenetic modifications also affect the immune response. We assessed CpG methylation in 22 inflammatory candidate genes (ATF2, CCL25, CXCL14, CXCL3, CXCL5, CXCL6, FADD, GATA3, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL15, IL17C, IL17RA, IL4R, IL6R, IL6ST, IL7, INHA, and TYK2) with respect to the occurrence of aggressive periodontitis (AgP). PATIENTS AND METHODS: In this study 15 AgP patients (53...
January 2016: Human Immunology
https://www.readbyqxmd.com/read/26458945/ham-tsp-derived-htlv-1-infected-t-cell-lines-promote-morphological-and-functional-changes-in-human-astrocytes-cell-lines-possible-role-in-the-enhanced-t-cells-recruitment-into-central-nervous-system
#19
Eduardo Samo Gudo, Suse Dayse Silva-Barbosa, Leandra Linhares-Lacerda, Marcelo Ribeiro-Alves, Suzana Corte Real, Dumith Chequer Bou-Habib, Wilson Savino
BACKGROUND: The mechanisms through which HTLV-1 leads to and maintains damage in the central nervous system of patients undergoing HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) are still poorly understood. In recent years, increasing evidence indicates that, not only lymphocytes but also glial cells, in particular astrocytes, play a role in the pathophysiology of HAM/TSP. In this study we used a model of co-culture between human HTLV-1-infected (CIB and C91PL) and non-infected (CEM) T lymphocyte cell lines and astrocyte (U251 and U87) cell lines to mimic the in vivo T cell-astrocyte interactions...
2015: Virology Journal
https://www.readbyqxmd.com/read/26388668/repressed-tgf-%C3%AE-signaling-through-caga-smad3-interaction-as-pathogenic-mechanisms-of-helicobacter-pylori-associated-gastritis
#20
Thuy Trang Nguyen, Seong-Jin Kim, Jong Min Park, Ki Baik Hahm, Ho-Jae Lee
Helicobacter pylori (H. pylori) infection causes chronic gastric inflammation, peptic ulceration, and gastric carcinogenesis, in which H. pylori cytotoxin-associated gene A (CagA) plays major pathogenic action. Since transforming growth factor-β (TGF-β) and its signaling also are principally implicated in either modulating gastric mucosal inflammatory responses or causing carcinogenesis and are attenuated after H. pylori infection, we hypothesized that dysregulated Smad signaling and repressed TGF-β might be core pathogenic mechanism for H...
September 2015: Journal of Clinical Biochemistry and Nutrition
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