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https://www.readbyqxmd.com/read/29909165/-hepatic-and-extra-hepatic-manifestations-of-hepatitis-e-virus-infection
#1
Hélène Blasco-Perrin, Jean-Marie Péron
All patients with elevated transaminases in France should be tested for HEV infection. HEV can cause severe hepatitis, in particular in patients with chronic liver disease, pregnant women and the elderly. Extra-hepatic manifestations including a number of neurologic syndromes, thrombopenia and renal injury have been described. HEV can cause chronic infection in immunosuppressed patients, in particular in organ-transplant recipients, patients with hematological malignancies and individuals with HIV. In patients with hematological malignancies, viral clearance can occur at the time of remission, with a risk of acute cytolysis and acute liver failure...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29905409/l-fabp-and-il-6-as-markers-of-chronic-kidney-damage-in-children-after-hemolytic-uremic-syndrome
#2
Katarzyna Lipiec, Piotr Adamczyk, Elżbieta Świętochowska, Katarzyna Ziora, Maria Szczepańska
BACKGROUND: Hemolytic-uremic syndrome (HUS) is a form of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). From a clinical point of view, it is important to search for markers that allow for early identification of patients at risk of a poor prognosis. OBJECTIVES: The study evaluated the serum and urine levels of liver-type fatty acid binding protein (L-FABP) and interleukin 6 (IL-6). MATERIAL AND METHODS: The study was conducted in 29 children with a history of HUS...
June 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29902864/protective-effect-of-acidic-polysaccharide-from-schisandra-chinensis-on-acute-ethanol-induced-liver-injury-through-reducing-cyp2e1-dependent-oxidative-stress
#3
Rongshuang Yuan, Xue Tao, Shuang Liang, Yan Pan, Li He, Jinghui Sun, Ju Wenbo, Xiangyan Li, Jianguang Chen, Chunmei Wang
AIM: Schisandra chinensis is a well-known traditional Chinese medicine used mainly as a recipe for hepatoprotection. Modern researches have revealed that the hepatoprotection is related to its lignans and crude polysaccharide. In this study, we examined the effect and mechanism of Schisandra chinensis acidic polysaccharide (SCAP) on the liver injury induced by ethanol. MAIN METHODS: SCAP was extracted with water extraction and ethanol precipitation. Liver injury models of both mice and HepG2 cells were produced by ethanol...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29902710/protective-effects-of-ginsenoside-rg1-against-lipopolysaccharide-d-galactosamine-induced-acute-liver-injury-in-mice-through-inhibiting-toll-like-receptor-4-signaling-pathway
#4
Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Xiaokui Huo, Zhihao Liu, Huijun Sun, Xiaobo Yang, Pengyuan Sun, Xiaodong Ma, Qiang Meng, Kexin Liu
Acute liver injury (ALI) is a dramatic liver disease characterized by large areas of inflammation in the liver. This study aimed to investigate the protective effects of ginsenoside Rg1 (Rg1), a biologically active component in Panax ginseng, on lipopolysaccharide/d-galactosamine (LPS/D-GalN)-induced ALI in mice, and meanwhile explore the molecular mechanism in vivo and in vitro. Mice were pretreated with Rg1 for three days prior to LPS (40 μg/kg)/D-GalN (700 mg/kg) administration. The results showed that Rg1 improved the survival rate and reduced the liver to body weight ratios in mice...
June 11, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29898789/co-stimulation-of-lpar-1-and-s1pr-1-3-increases-the-transplantation-efficacy-of-human-mesenchymal-stem-cells-in-drug-induced-and-alcoholic-liver-diseases
#5
Mianhuan Li, Yi Lv, Feng Chen, Xiaoyan Wang, Jiang Zhu, Hao Li, Jia Xiao
BACKGROUND: One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue. The aim of this study was to delineate the mechanistic involvement of lysophosphatidic acid receptors (LPARs) and sphingosine-1-phosphate receptors (S1PRs) in the regulation of anti-stress and transplantation efficacy of stem cells. METHODS: Human adipose-derived mesenchymal stem cells (hADMSCs) were treated with chemical toxin or ethanol to induce cell stress...
June 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29897827/a-metabolomic-perspective-of-pazopanib-induced-acute-hepatotoxicity-in-mice
#6
Yi-Kun Wang, Xiao-Nan Yang, Wei-Qing Liang, Yao Xiao, Qi Zhao, Xue-Rong Xiao, Frank J Gonzalez, Fei Li
1. To elucidate the metabolism of pazopanib, a metabolomics approach was performed based on ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry. 2. A total of 22 pazopanib metabolites were identified in vitro and in vivo. Among these metabolites, 17 were novel, including several cysteine adducts and aldehyde derivatives. By screening using recombinant CYPs, CYP3A4 and CYP1A2 were found to be the main forms involved in the pazopanib hydroxylation. Formation of a cysteine conjugate (M3), an aldehyde derivative (M15) and two N-oxide metabolites (M18 and M20) from pazopanib could induce the oxidative stress that may be responsible in part for pazopanib-induced hepatotoxicity...
June 13, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29897530/metabolism-and-toxicity-of-trichloroethylene-and-tetrachloroethylene-in-cytochrome-p450-2e1-knockout-and-humanized-transgenic-mice
#7
Yu-Syuan Luo, Shinji Furuya, Valerie Y Soldatov, Oksana Kosyk, Hong Sik Yoo, Hisataka Fukushima, Lauren Lewis, Yasuhiro Iwata, Ivan Rusyn
Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with metabolism to oxidative and glutathione conjugation moieties. It is thought that CYP2E1 is crucial to the oxidative metabolism of TCE and PCE, and may also play a role in formation of nephrotoxic metabolites; however, inter-species and inter-individual differences in contribution of CYP2E1 to metabolism and toxicity are not well understood...
April 20, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29896798/renal-effects-of-norepinephrine-induced-variations-in-mean-arterial-pressure-after-liver-transplantation-a-randomized-cross-over-trial
#8
J Skytte Larsson, G Bragadottir, B Redfors, S-E Ricksten
BACKGROUND: Acute kidney injury is commonly seen after liver transplantation. The optimal perioperative target mean arterial pressure (MAP) for renal filtration, perfusion and oxygenation in liver recipients is not known. The effects of norepinephrine-induced changes in MAP on renal blood flow (RBF), oxygen delivery (RDO2 ), glomerular filtration rate (GFR) and renal oxygenation (=renal oxygen extraction, RO2 Ex) were therefore studied early after liver transplantation. METHODS: Ten patients with an intra- and post-operative vasopressor-dependent systemic vasodilation were studied early after liver transplantation during sedation and mechanical ventilation...
June 12, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29895518/disseminated-cryptococcosis-associated-with-administration-of-eculizumab
#9
Megan Clancy, Ryan McGhan, Jeremy Gitomer, Ana Marie Inocencio, Christina Aldrich, Roberto Iaderosa, Ryan Stevens
PURPOSE: A case report of fatal disseminated cryptococcosis in a patient treated with eculizumab is presented along with a review of literature suggesting a possible etiologic mechanism. SUMMARY: A 23-year-old man with a history of minimal change nephrotic syndrome was hospitalized for acute kidney injury and abdominal pain and swelling. He was found to have disseminated pneumococcal disease, including peritonitis, bacteremia, and pulmonic endocarditis. The patient developed evidence of microangiopathic hemolytic anemia, leading to a diagnosis of atypical hemolytic uremic syndrome, and was started on eculizumab...
June 12, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29895352/direct-comparison-of-the-thioacetamide-and-azoxymethane-models-of-type-a-hepatic-encephalopathy-in-mice
#10
Stephanie Grant, Matthew McMillin, Gabriel Frampton, Anca D Petrescu, Elaina Williams, Victoria Jaeger, Jessica Kain, Sharon DeMorrow
Acute liver failure is a devastating consequence of hepatotoxic liver injury that can lead to the development of hepatic encephalopathy. There is no consensus on the best model to represent these syndromes in mice and therefore the aim of this study was to classify hepatic and neurological consequences of azoxymethane- and thioacetamide-induced liver injury. Azoxymethane-treated mice were euthanized at time points representing absence of, minor and significant stages of neurological decline. Thioacetamidetreated mice had tissue collected at up to 3 days following daily injections...
June 12, 2018: Gene Expression
https://www.readbyqxmd.com/read/29895168/functional-3d-human-liver-bud-assembled-from-msc-derived-multiple-liver-cell-lineages
#11
Jing Li, Feiyue Xing, Feng Chen, Liumin He, Kwok-Fai So, Yingxia Liu, Jia Xiao
The severe shortage of donor liver organs requires the development of alternative methods to provide transplantable liver tissues such as stem cell-derived organoids. Despite several studies describing the generation of vascularized and functional liver tissues, none have succeeded in assembling human liver buds containing hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs). Here, we report a reproducible, easy-to-follow, and comprehensive self-assembly protocol to generate three-dimensional (3D) human liver buds from naïve mesenchymal stem cells (MSCs), MSC-derived hepatocytes, and HSC- and LSEC-like cells...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29894864/dopamine-alleviated-acute-liver-injury-induced-by-lipopolysaccharide-d-galactosamine-in-mice
#12
Honghong Zhou, Li Tang, Yongqiang Yang, Ling Lin, Jie Dai, Pu Ge, Qing Ai, Rong Jiang, Li Zhang
Dopamine (DA), a crucial neurotransmitter, not only functions in the central nervous system but also plays important roles in the modulation of inflammation. Several studies suggest that DA might suppress the inflammatory response both in vitro and in vivo. In the present study, the potential effects of DA in a mouse model with lipopolysaccharide (LPS)/d-galactosamine (D-Gal)-induced acute liver injury were investigated. The results show that DA-treated LPS/D-Gal-exposed mice had reduced incidence of histologic lesions, lower plasma aminotransferases and improved the survival rates compared to LPS/D-Gal-exposed mice...
June 9, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29893707/undue-elevation-of-procalcitonin-in-pediatric-paracetamol-intoxication-is-not-explained-by-liver-cell-injury-alone
#13
Eva Tschiedel, Roland Assert, Ursula Felderhoff-Müser, Simone Kathemann, Oliver Witzke, Peter Hoyer, Christian Dohna-Schwake
INTRODUCTION AND AIM: Procalcitonin is widely used as a biomarker to distinguish bacterial infections from other etiologies of systemic inflammation. Little is known about its value in acute liver injury resulting from intoxication with paracetamol. MATERIAL AND METHODS: We performed a single-center retrospective analysis of the procalcitonin level, liver synthesis, liver cell damage and renal function of patients admitted with paracetamol-induced liver injury to a tertiary care children's hospital...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893703/urinary-neutrophil-gelatinase-associated-lipocalin-in-cirrhotic-patients-with-acute-kidney-injury
#14
Hassan S Hamdy, Ahmed El-Ray, Mohamed Salaheldin, Mohammad Lasheen, Mohamed Aboul-Ezz, Ahmed S Abdel-Moaty, Ali Abdel-Rahim
INTRODUCTION AND AIM: It is well known that development of acute kidney injury (AKI) increases mortality in hospitalized cirrhotic patients; therefore many novel markers have been studied for early detection, differential diagnosis and prognosis in cirrhotic patients with AKI. The aim of the current work is to evaluate urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a diagnostic biomarker for different causes of acute kidney injury in liver cirrhosis and to assess it as a prognostic marker...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29892177/acute-on-chronic-liver-failure-in-hospital-predictors-of-mortality-in-icu
#15
Sujay Kulkarni, Mithun Sharma, Padaki N Rao, Rajesh Gupta, Duvvuru N Reddy
Aims: We studied in-hospital predictors of mortality of acute on chronic liver failure (ACLF) in Indian patients. Methods: Patients admitted to the intensive care unit of our institute fulfilling the definition of ACLF based on the Asia-Pacific Association for Study of Liver Disease (APASL) consensus were included. Complete history and medical evaluation to assess the etiology of underlying liver cirrhosis and to identify the acute precipitating insult of worsening liver function was done...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29891465/-mixed-amanita-phalloides-poisoning-with-rhabdomyolysis-analysis-of-4-cases
#16
Zhan Lu, Yan-Bo Chen, Bo Huang, Sheng Peng, Qian-Wen Wang, Dan-Lei Liu, Hua Wang
We report the clinical characteristics, treatments and outcomes of 4 rare cases of mixed amanita fuliginea and amanita rimosa poisoning with rhabdomyolysis, and review the research progress in the intoxication mechanism and treatment. The latent time of amanita poisoning, defined as the period from the ingestion of poisonous mushroom to the onset of gastrointestinal symptoms, was about 8 days, and the severity of poisoning was associated with the amount of mushroom ingested. All the 4 patients developed multiple organ dysfunctions within 3 to 4 days after mushroom ingestion, predominantly in the liver, kidney and central nervous system accompanied with acute gastrointestinal injury and rhabdomyolysis...
May 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29891225/acute-kidney-injury-after-pediatric-cardiac-surgery
#17
REVIEW
Shi-Min Yuan
Acute kidney injury (AKI) is a common complication of pediatric cardiac surgery and is associated with increased morbidity and mortality. Literature of AKI after pediatric cardiac surgery is comprehensively reviewed in terms of incidence, risk factors, biomarkers, treatment and prognosis. The novel RIFLE (pediatric RIFLE for pediatrics), Acute Kidney Injury Network (AKIN) and Kidney Disease Improving Global Outcomes (KDIGO) criteria have brought about unified diagnostic standards and comparable results for AKI after cardiac surgery...
March 30, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29889816/murine-pancreatic-cancer-alters-t-cell-activation-and-apoptosis-and-worsens-survival-after-cecal-ligation-and-puncture
#18
John D Lyons, Ching-Wen Chen, Zhe Liang, Wenxiao Zhang, Deena B Chihade, Eileen M Burd, Alton B Farris, Mandy L Ford, Craig Coopersmith
Patients with cancer who develop sepsis have a markedly higher mortality than patients who were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference have previously been examined in two preclinical models of cancer followed by sepsis. Both pancreatic cancer/pneumonia and lung cancer/cecal ligation and puncture (CLP) increase murine mortality, associated with alterations in lymphocyte apoptosis and intestinal integrity. However, pancreatic cancer/pneumonia decreases lymphocyte apoptosis and increases gut apoptosis while lung cancer/CLP increases lymphocyte apoptosis and decreases intestinal proliferation...
June 8, 2018: Shock
https://www.readbyqxmd.com/read/29889676/single-dose-rivaroxaban-induced-acute-liver-injury
#19
Elijah Verheyen, John A Kileci, Joseph P Mathew
No abstract text is available yet for this article.
May 30, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29889497/acid-promoted-d-a-d-type-far-red-fluorescent-probe-with-high-photostability-for-lysosomal-nitric-oxide-imaging
#20
Fengyang Wang, Shujuan Yu, Zhiai Xu, Lingling Li, Yijing Dang, Xiaowei Xu, Yi Luo, Zhen Cheng, Haijun Yu, Wen Zhang, Ao Zhang, Chunyong Ding
To accurately monitor the variations of lysosomal nitric oxide (NO) under physiological condition remains a great challenge for understanding the biological function of NO. Herein, we developed a new chemotype probe, namely, MBTD, for acid-promoted and far-red fluorescence imaging of lysosomal NO in vitro and ex vivo. MBTD was rationally designed by incorporating o-phenylenediamino (OPD) moiety into the donor-acceptor-donor (D-A-D) type fluorophore based on a dual intramolecular charge transfer (ICT) mechanism...
June 11, 2018: Analytical Chemistry
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