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Antipyretics

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https://www.readbyqxmd.com/read/28448685/adult-neurobehavioral-alterations-in-male-and-female-mice-following-developmental-exposure-to-paracetamol-acetaminophen-characterization-of-a-critical-period
#1
Gaëtan Philippot, Torsten Gordh, Anders Fredriksson, Henrik Viberg
Paracetamol (acetaminophen) is a widely used non-prescription drug with analgesic and antipyretic properties. Among pregnant women and young children, paracetamol is one of the most frequently used drugs and is considered the first-choice treatment for pain and/or fever. Recent findings in both human and animal studies have shown associations between paracetamol intake during brain development and adverse behavioral outcomes later in life. The present study was undertaken to investigate if the induction of these effects depend on when the exposure occurs during a critical period of brain development and if male and female mice are equally affected...
April 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28437805/anti-inflammatory-antipyretic-and-antinociceptive-effects-of-a-cressa-cretica-aqueous-extract
#2
Heba Mohammed Ibrahim Abdallah, Abdelsamed Ibrahim Elshamy, Abd El-Nasser Gaber El Gendy, Ahmed Mohamed Abd El-Gawad, Elsayed Abouelfotowh Omer, Marinella De Leo, Luisa Pistelli
Cressa cretica is a widely grown halophytic plant traditionally used for the treatment of different ailments. Previous investigations reported its biological activity on a wide spectrum of diseases. In this study, in vivo antinociceptive, anti-inflammatory, and antipyretic activities of C. cretica aqueous extract whole plant were evaluated. In addition, the total polyphenol content, the total flavonoid content, and the chemical characterization of the extract were performed. C. cretica showed writhing inhibition in acetic acid-induced peripheral nociception of 43 and 48 % at doses of 50 and 100 mg/kg, respectively...
April 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28437025/effectiveness-of-paracetamol-versus-ibuprofen-administration-in-febrile-children-a-systematic-literature-review
#3
Kaajal Narayan, Simon Cooper, Julia Morphet, Kelli Innes
AIM: The use of antipyretics to manage the febrile child is becoming increasingly popular. Paracetamol and ibuprofen are the most commonly used interventions to manage fever in children; however, there have been no comparative analyses. The aim of the study is to evaluate the evidence comparing paracetamol to ibuprofen in the treatment of fever in children. METHODS: A systematic review of randomised controlled trials investigating the administration of oral paracetamol and ibuprofen to reduce fever in children...
April 24, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28425044/systematic-review-for-geo-authentic-lonicerae-japonicae-flos
#4
REVIEW
Xingyue Yang, Yali Liu, Aijuan Hou, Yang Yang, Xin Tian, Liyun He
In traditional Chinese medicine, Lonicerae Japonicae Flos is commonly used as anti-inflammatory, antiviral, and antipyretic herbal medicine, and geo-authentic herbs are believed to present the highest quality among all samples from different regions. To discuss the current situation and trend of geo-authentic Lonicerae Japonicae Flos, we searched Chinese Biomedicine Literature Database, Chinese Journal Full-text Database, Chinese Scientific Journal Full-text Database, Cochrane Central Register of Controlled Trials, Wanfang, and PubMed...
April 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28424024/molecular-profiling-and-bioactive-potential-of-an-endophytic-fungus-aspergillus-sulphureus-isolated-from-sida-acuta-a-medicinal-plant
#5
M Murali, C Mahendra, P Hema, N Rajashekar, A Nataraju, M S Sudarshana, K N Amruthesh
CONTEXT: Sida acuta Burm.f. (Malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. No fungal endophytes of S. acuta are reported. OBJECTIVE: Isolation, identification and evaluation of antibacterial, antioxidant, anticancer and haemolytic potential of fungal endophytes from the ethnomedcinal plant S. acuta. MATERIALS AND METHODS: Sida acuta stem segments were placed on PDA medium to isolate endophytic fungi...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28418802/transfer-of-low-dose-aspirin-into-human-milk
#6
Palika Datta, Kathleen Rewers-Felkins, Raja Reddy Kallem, Teresa Baker, Thomas W Hale
BACKGROUND: Aspirin has antipyretic and anti-inflammatory properties and is frequently used by pregnant and lactating women. However, its transfer in human milk when administered at low dose has not been reported. Research aim: This study aimed to evaluate the transfer of acetylsalicylic acid and its metabolite, salicylic acid, into human milk following the use of low dose aspirin. METHODS: In this study, milk samples were collected at 0, 1, 2, 4, 8, 12, and 24 hours from seven breastfeeding women after a steady-state daily dose of 81 mg of aspirin...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28394301/structural-analysis-and-immuno-stimulating-activity-of-an-acidic-polysaccharide-from-the-stems-of-dendrobium-nobile-lindl
#7
Jun-Hui Wang, Shu-Rong Zuo, Jian-Ping Luo
Dendrobium nobile Lindl., an epiphytic herb distributed in the Southeast Asia, is used as a tonic and antipyretic herbal medicine in China. In this study, a water-soluble acidic heteropolysaccharide, DNP-W4, containing mannose, glucose, galactose, xylose, rhamnose, and galacturonic acid, in the molar ratios of 1.0:4.9:2.5:0.5:1.0:0.9, was obtained from the stems of Dendrobium nobile Lindl. Using methylation analysis, partial acid hydrolysis, pectolyase treatment, NMR, and ESI-MS, the structure of DNP-W4 was elucidated...
April 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28392690/hyaluronic-acid-nimesulide-conjugates-as-anticancer-drugs-against-cd44-overexpressing-ht-29-colorectal-cancer-in-vitro-and-in-vivo
#8
You-Sin Jian, Ching-Wen Chen, Chih-An Lin, Hsiu-Ping Yu, Hua-Yang Lin, Ming-Yuan Liao, Shu-Huan Wu, Yan-Fu Lin, Ping-Shan Lai
Carrier-mediated drug delivery systems are promising therapeutics for targeted delivery and improved efficacy and safety of potent cytotoxic drugs. Nimesulide is a multifactorial cyclooxygenase 2 nonsteroidal anti-inflammatory drug with analgesic, antipyretic and potent anticancer properties; however, the low solubility of nimesulide limits its applications. Drugs conjugated with hyaluronic acid (HA) are innovative carrier-mediated drug delivery systems characterized by CD44-mediated endocytosis of HA and intracellular drug release...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28390086/virtual-screening-and-biological-evaluation-of-novel-antipyretics-compounds
#9
Thamires Quadros Froes, Miriam C C Melo, Gloria E P Souza, Marcelo Santos Castilho, Denis M Soares
Due to the absence ofsafety of the antipyretics to patients withcardiovascular dysfunction,new targets to treatinflammation have been pursued. mPGES-1 is a promising target because its inhibition would not cause the side effectsrelated to COX inhibition. In order to identify novel inhibitorsof mPGES-1, we developed a ligand-basedpharmacophoremodel that differentiates true inhibitors from decoys andenlightens the structure-activity relationships for known mPGES-1 inhibitors.The model (4 hydrophobic centers, 2 hydrogen-bond acceptor and 2 hydrogen-bond donor points) was employed to select lead-like compoundsfrom ZINC database forin vivo evaluation...
April 8, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28386165/effect-of-antipyretic-therapy-on-mortality-in-critically-ill-patients-with-sepsis-receiving-mechanical-ventilation-treatment
#10
Sheng Ye, Dan Xu, Chenmei Zhang, Mengyao Li, Yanyi Zhang
Purpose. The study aimed to investigate the effectiveness of antipyretic therapy on mortality in critically ill patients with sepsis requiring mechanical ventilation. Methods. In this study, we employed the multiparameter intelligent monitoring in intensive care II (MIMIC-II) database (version 2.6). All patients meeting the criteria for sepsis and also receiving mechanical ventilation treatment were included for analysis, all of whom suffer from fever or hyperthermia. Logistic regression model and R language (R version 3...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28385078/paris-polyphylla-suppresses-proliferation-and-vasculogenic-mimicry-of-human-osteosarcoma-cells-and-inhibits-tumor-growth-in-vivo
#11
Nan Yao, Ke Ren, Yimin Wang, Qiaomei Jin, Xiao Lu, Yan Lu, Cuihua Jiang, Dongjian Zhang, Jun Lu, Chen Wang, Jiege Huo, Yong Chen, Jian Zhang
Paris polyphylla, a traditional antipyretic-detoxicate chinese medicinal herb, has been applied extensively in cancer treatments for nearly 2000 years. The purpose of the present study is to evaluate the potential anti-osteosarcoma effects of Paris polyphylla ethanol extract (PPEE) and to investigate its underlying mechanisms. The antiproliferation activity of PPEE was tested on 143B, MG-63, U-2 OS and hFOB1.19 cells using MTT assay. The pro-apoptotic and cell cycle arrest effects of PPEE were confirmed by Hoechst 33342 staining and flow cytometry...
April 6, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28383097/prevalence-of-self-medication-among-university-students-in-baghdad-a-cross-sectional-study-from-iraq
#12
Rawa J K Al-Ameri, Husham J Abd Al-Badri, Riyadh K Lafta
The objective of this study is to find out the prevalence and determinants of self-medication among college students in Baghdad, Iraq. A cross-sectional survey was conducted in Al-Mustansiriyah and Al-Nahrain universities, Baghdad, from January to April 2015. A multistage random sampling technique was adopted to collect data from 1435 college students using a questionnaire form. The mean age of the joining students was 19.8 years. Females form 53% of the sample. Self-medications use was prevalent among 92.4% of students...
March 30, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28379590/hepatotoxicity-of-paracetamol-and-related-fatalities
#13
R Tittarelli, M Pellegrini, M G Scarpellini, E Marinelli, V Bruti, N M di Luca, F P Busardò, S Zaami
Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available over-the-counter as a single formulation or in combination with other substances and, as indicated by the World Health Organization, it can be used in all the three steps of pain intensity. Paracetamol toxicity is one of the most common causes of poisoning worldwide. While paracetamol is described as relatively nontoxic when administered in therapeutic doses, it is known to cause toxicity when taken in a single or repeated high dose, or after chronic ingestion...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28379215/effects-of-cornus-mas-l-and-morus-rubra-l-extracts-on-penicillin-induced-epileptiform-activity-an-electrophysiological-and-biochemical-study
#14
RANDOMIZED CONTROLLED TRIAL
Filiz Tubaş, Sedat Per, Abdulkadir Taşdemir, Ayşe Kaçar Bayram, Mehmet Yıldırım, Aydın Uzun, Recep Saraymen, Hakan Gümüş, Ferhan Elmalı, Hüseyin Per
Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin-induced epileptiform activity...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28378280/efficacy-of-phenyl-quinoline-phenol-derivatives-as-cox-2-inhibitors-an-approach-to-emergent-the-small-molecules-as-the-anti-inflammatory-and-analgesic-therapeutics
#15
A Manikandan, S Ravichandran, K I Sathiyanarayanan, A Sivakumar
2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequently, to get more insight into the binding mode with COX-2, compounds 4a-l were docked into the COX-2 (PDB ID: 1CX2) active site. In the Human Red Blood Cells (HRBC) membrane stabilization assay (in vitro anti-inflammatory), compounds 4f (IC50 0...
April 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28374069/mu-and-kappa-opioid-receptors-of-the-periaqueductal-gray-stimulate-and-inhibit-thermogenesis-respectively-during-psychological-stress-in-rats
#16
Caroline Cristina-Silva, Victor Martins, Luciane H Gargaglioni, Kênia C Bícego
The periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in body temperature (Tb) regulation during psychological stress such as restraint. Because activation of mu and kappa receptors increases and reduces Tb, respectively, we tested the hypothesis that they exert excitatory and inhibitory modulation, respectively, of the restraint-induced fever in rats...
April 4, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28370746/low-dose-naltrexone-and-opioid-consumption-a-drug-utilization-cohort-study-based-on-data-from-the-norwegian-prescription-database
#17
Guttorm Raknes, Lars Småbrekke
PURPOSE: Low-dose naltrexone (LDN) is used in a wide range of conditions, including chronic pain and fibromyalgia. Because of the opioid antagonism of naltrexone, LDN users are probably often warned against concomitant use with opioids. In this study, based on data from the Norwegian prescription database, we examine changes in opioid consumption after starting LDN therapy. METHODS: We included all Norwegian patients (N = 3775) with at least one recorded LDN prescription in 2013 and at least one dispensed opioid prescription during the 365 days preceding the first LDN prescription...
March 29, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28366286/effect-of-paracetamol-acetaminophen-on-body-temperature-in-acute-stroke-a-meta-analysis
#18
Junjie Fang, Chensong Chen, Hongsen Cheng, Ren Wang, Linhao Ma
PURPOSE: The objective of this study was to assess the efficacy of paracetamol (acetaminophen) on body temperature in acute stroke. METHODS: Medline, Cochrane Central Register of Controlled Trials, EMBASE, Chinese BioMedical Literature Database, China National Knowledge Infrastructure, and the World Health Organization (WHO) International Clinical Trials Registry Platform were searched electronically. Relevant journals and references of studies included were hand-searched for randomized controlled trials (RCT) and controlled clinical trials (CCT) regarding the efficacy of paracetamol (acetaminophen) on body temperature in acute stroke...
March 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28364306/-antipyretics-in-intensive-care-patients
#19
A Simon, A Leffler
BACKGROUND: Antipyretics are among the most widely prescribed drugs in German hospitals. Despite this widespread use, their role for treatment of critically ill patients still remains unclear. In particular, the questionable positive effects of reducing fever are discussed. OBJECTIVES: In this review we aimed to summarize and discuss current study results covering the use of antipyretics in critically ill patients. Suspected effects with regard to fever reduction and lethality should be considered...
March 31, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28360907/aspirin-the-mechanism-of-action-revisited-in-the-context-of-pregnancy-complications
#20
REVIEW
Angela P Cadavid
Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the non-steroidal anti-inflammatory drugs with a wide range of pharmacological activities, including analgesic, antipyretic, and antiplatelet properties. Currently, it is accepted to prescribe a low dose of aspirin to pregnant women who are at high risk of preeclampsia (PE) because it reduces the onset of this complication. Another pregnancy alteration in which a low dose of aspirin is recommended is the obstetric antiphospholipid syndrome (APS)...
2017: Frontiers in Immunology
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