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https://www.readbyqxmd.com/read/29441826/protective-effect-of-an-l-type-calcium-channel-blocker-amlodipine-on-paracetamol-induced-hepatotoxicity-in-rats
#1
H Kaya, B Polat, A Albayrak, T Mercantepe, B Buyuk
Paracetamol (P), one of the most popular and commonly used analgesic and antipyretic agents, causes hepatotoxicity in overdoses. Amlodipine (AML), an L-type calcium channel blocker, has been shown to have anti-inflammatory activity by reversing the effect of calcium in the inflammation pathogenesis. In this study, the hepatoprotective activity of AML on P-induced hepatotoxicity was evaluated. Thirty male albino Wistar rats were divided into five groups: (1) control, (2) 2 g/kg of P, (3) 2 g/kg of P + 5 mg/kg of AML, (4) 2 g/kg of P + 10 mg/kg of AML, and (5) 10 mg/kg of AML...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29435278/enhanced-analgesic-effects-of-nefopam-in-combination-with-acetaminophen-in-rodents
#2
Qian Li, Quankun Zhuang, Yaru Gu, Cailing Dai, Xiaoxiao Gao, Xiaomin Wang, Huimin Wen, Xin Li, Yuyang Zhang
Nefopam, an analgesic drug, effectively elicits antinociception in the majority of noxious and thermal models in rodents. Acetaminophen is among the most commonly used analgesic and antipyretic drugs worldwide, either on prescription or over the counter. The present study aimed to investigate the analgesic activity of nefopam combined with acetaminophen, which was expected to maximize the potency of analgesia and decrease the dose of nefopam required. Three series of experiments, namely acetic acid-induced writhing tests in mice, hot plate tests in mice and tail flick tests in rats, were used to evaluate the analgesic effect...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29432206/evaluation-of-hematological-alterations-after-therapeutic-use-of-dipyrone-in-healthy-adults-a-prospective-study
#3
Ernane C de Souza, Dalyara M Matos, Milainy R Viana, Marcela C O Alvim, Herval L Bonfante, Alexandre F Pinto, Jorge W L Nascimento
BACKGROUND: Dipyrone is a non-narcotic analgesic/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone. METHODS: The study enrolled 30 healthy volunteers of both genders, aged 19-37 years. They received tablets containing 500 mg of dipyrone sodium to be used four times daily for 7 consecutive days...
February 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29428241/ethnomedical-uses-and-pharmacological-activities-of-most-prevalent-species-of-genus-piper-in-panama-a-review
#4
REVIEW
Armando A Durant-Archibold, Ana I Santana, Mahabir P Gupta
ETHNOPHARMACOGICAL RELEVANCE: Piperaceae is the fifth largest family of plants in Panama. This review focuses on the ethnomedical uses of the most prevalent Panamanian species and biological activities of their extracts and/or constituents both in Panama and worldwide. Many species have a plethora of ethnomedical uses such as antibacterial, antifungal, anti-inflammatory, anticancer, antidiabetic, anti-Helicobacter pylori, antiulcer, antiprotozoal, estrogenic, insecticidal, local anesthetic, diuretic, and for women's health conditions...
February 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29422733/quad-fever-treatment-through-lowering-of-ambient-temperature
#5
Shyam Sundar Krishnan, Pulak Nigam, Omar Bachh, Madabushi Chakravarthy Vasudevan
Hyperpyrexia is a rare and at times fatal condition seen in an Intensive Care Unit setup. We encountered a case of a 65-year-old patient with road traffic accident presenting with dorsal spine fracture at D10 level. He underwent decompression and fusion for the same. He developed hyperpyrexia of sudden onset on the 10th day of admission with no source of infection and adequate broad-spectrum antibiotic coverage with adequate thrombo-embolic prevention in place. The patient showed no response to antipyretic agents and other cooling methods...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29406467/subtype-specific-clinical-presentation-medical-treatment-and-family-impact-of-influenza-in-children-one-to-five-years-of-age-treated-in-outpatient-practices-in-germany-during-three-post-pandemic-years-2013-2015
#6
Andrea Streng, Christiane Prifert, Benedikt Weissbrich, Andreas Sauerbrei, Ruprecht Schmidt-Ott, Johannes G Liese
BACKGROUND: Limited data on the influenza burden in pediatric outpatients are available, especially regarding direct comparison of the co-circulating (sub)types A(H1N1)pdm09, A(H3N2) and B. METHODS: Children 1-5 years of age, unvaccinated against influenza and presenting with febrile acute respiratory infections (ARI), were enrolled in 33 paediatric practices in Germany from 2013-2015 (January-May). Influenza was confirmed by multiplex PCR from pharyngeal swabs and (sub)typed...
February 5, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29401360/using-web-based-questionnaires-to-assess-medication-use-during-pregnancy-a-validation-study-in-2-prospectively-enrolled-cohorts
#7
Marleen M H J van Gelder, Saskia Vorstenbosch, Bernke Te Winkel, Eugène P van Puijenbroek, Nel Roeleveld
Medication use is often underreported in paper-based questionnaires or interviews. Web-based questionnaires may improve recall of medication use, but data on their validity are currently lacking. Participants in the Pregnancy and Infant Development (PRIDE) Study (2014-2016; n = 557) and the Pregnancy Drug Registry (pREGnant) (2015-2016; n = 169) completed a 6-week paper-based medication diary during gestational weeks 19-24 or 26-31. In week 34, they completed a Web-based questionnaire with questions on medication names, time period and frequency of use, and quantity taken...
February 1, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29397094/cytotoxic-activity-of-the-chemical-constituents-of-clerodendrum-indicum-and-clerodendrum-villosum-roots
#8
Pathom Somwong, Rutt Suttisri
OBJECTIVE: The roots of two Thai medicinal plants, Clerodendrum indicum and Clerodendrum villosum are found in traditional medicine practices. The aim of this research was to preliminarily study the cytotoxicity of extracts of their roots, and the parts that possessed cytotoxic activity were separated on a chromatograph to identify their active compounds. METHODS: The extracts of both plants were screened for cytotoxicity on the SW620 cell line and the compounds isolated from the active extracts were further evaluated for their cytotoxic activity against five human cancer cell lines, including SW620, ChaGo-K-1, HepG2, KATO-III and BT-474 using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay...
January 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29393462/extracts-from-guava-fruit-protect-renal-tubular-endothelial-cells-against-acetaminophen%C3%A2-induced-cytotoxicity
#9
Tsai-Kun Wu, Hsiao-Chun Liu, Shu-Yu Lin, Yung-Luen Yu, Chyou-Wei Wei
Acetaminophen (APAP) is an analgesic and antipyretic agent primarily used in the clinical setting. However, high doses of APAP can cause oxidative stress. Guavas have been reported to provide anti‑inflammatory, anti‑microbial, anti‑oxidative and anti‑diarrheal functions. In addition, guavas have been reported to prevent renal damage due to progression of diabetes mellitus. Therefore, the aim of the present study was to investigate whether guavas can reduce APAP‑induced renal cell damage. In the present study, extracts from guavas were obtained and added to APAP‑treated renal tubular endothelial cells...
January 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29386439/-survey-of-description-on-package-inserts-of-otc-drugs
#10
Akari Shimauchi, Misa Naganuma, Sayaka Sasaoka, Haruna Hatahira, Yumi Motooka, Shiori Hasegawa, Akiho Fukuda, Satoshi Nakao, Chihiro Sakai, Satoshi Yokoyama, Yoko Ino, Mitsuhiro Nakamura, Kazuhiro Iguchi
 The "self-medication tax deduction" system began in Japan in January 2017, allowing people to encourage the use of OTC drugs. Package inserts contain important information for consumers regarding their use. In this study, we first checked whether the items, as required in the notifications of the Japanese Ministry of Health, Labour and Welfare, are described in the package inserts of cold remedies and analgesic antipyretics in OTC drugs. The descriptions of almost all packages checked in this study were based on the notifications, but those of a small number of them were not...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29385849/development-of-paracetamol-caffeine-co-crystals-to-improve-compressional-formulation-and-in-vivo-performance
#11
Sumera Latif, Nasir Abbas, Amjad Hussain, Muhammad Sohail Arshad, Nadeem Irfan Bukhari, Hafsa Afzal, Sualeha Riffat, Zeeshan Ahmad
Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared and delineated. Co-crystals exhibited improved compaction and mechanical behavior. A screening study was performed by utilizing a number of methods namely dry grinding, liquid assisted grinding (LAG), solvent evaporation (SE) and anti-solvent addition using various weight ratios of starting materials...
February 1, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29371328/role-of-combined-prenatal-and-postnatal-paracetamol-exposure-on-asthma-development-the-czech-elspac-study
#12
Pavel Piler, Jan Švancara, Lubomír Kukla, Hynek Pikhart
BACKGROUND: Prenatal and postnatal paracetamol exposure has been previously associated with asthma development in childhood in Western populations. We explore the association between prenatal and postnatal paracetamol exposure and asthma development in a Central European sample of Czech children, suggesting possible additive effect of the both exposures. Furthermore, since aspirin had been used more widely during study data collection in Central Europe, we also compared asthma development for those exposed to paracetamol and aspirin...
January 25, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29352476/pharmacokinetic-profiles-of-the-active-metamizole-metabolites-after-four-different-routes-of-administration-in-healthy-dogs
#13
M Giorgi, B Łebkowska-Wieruszewska, A Lisowski, H Owen, A Poapolathep, T W Kim, V De Vito
Metamizole (MT), an analgesic and antipyretic drug, is rapidly hydrolyzed to the active primary metabolite 4-methylaminoantipyrine (MAA) and relatively active secondary metabolite 4-aminoantipyrine (AA). The aim of this study was to assess the pharmacokinetic profiles of MAA and AA after dose of 25 mg/kg MT by intravenous (i.v.), intramuscular (i.m.), oral (p.o.), and rectal (RC) routes in dogs. Six dogs were randomly allocated to an open, single-dose, four-treatment, four-phase, unpaired, crossover study design...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29349608/comparative-transcriptomics-uncovers-differences-in-photoautotrophic-versus-photoheterotrophic-modes-of-nutrition-in-relation-to-secondary-metabolites-biosynthesis-in-swertia-chirayita
#14
Tarun Pal, Jibesh Kumar Padhan, Pawan Kumar, Hemant Sood, Rajinder S Chauhan
Swertia chirayita is a high-value medicinal herb exhibiting antidiabetic, hepatoprotective, anticancer, antiediematogenic and antipyretic properties. Scarcity of its plant material has necessitated in vitro production of therapeutic metabolites; however, their yields were low compared to field grown plants. Possible reasons for this could be differences in physiological and biochemical processes between plants grown in photoautotrophic versus photoheterotrophic modes of nutrition. Comparative transcriptomes of S...
January 18, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29348090/pharmacological-validation-of-the-folkloric-uses-of-cyperus-rotundus-l-in-different-ailments-an-in-vivo-and-in-vitro-research
#15
Musaddique Hussain, Hafiz Muhammad Waqas, Ikhlaq Hussain, Abdul Majeed, Shahid Masood Raza, Khalid Hussain Janbaz
In vivo and in vitro research study was conducted on Cyperus rotundus to evaluate the sound mechanistic background in the treatment of gastrointestinal, bronchial and vascular disorders as well as in pain, emesis, pyrexia and bacterial infections. Results showed that crude extract of Cyperus rotundus (Cr.Cr) exhibited the dose-dependent spasmolytic effect in rabbit jejunum by inhibiting the spontaneous and K+ (80 mM)-induced contractions. Pretreatment of tissue with Cr. Cr caused the rightward shift of calcium concentration response curves, similar to verapamil...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29344419/dendrobium-sources-of-active-ingredients-to-treat-age-related-pathologies
#16
REVIEW
Veronika Cakova, Frederic Bonte, Annelise Lobstein
Dendrobium represents one of the most important orchid genera, ornamentally and medicinally. Dendrobiums are sympodial epiphytic plants, which is a name they are worthy of, the name coming from Greek origin: "dendros", tree, and "bios", life. Dendrobium species have been used for a thousand years as first-rate herbs in traditional Chinese medicine (TCM). They are source of tonic, astringent, analgesic, antipyretic, and anti-inflammatory substances, and have been traditionally used as medicinal herbs in the treatment of a variety of disorders, such as, nourishing the stomach, enhancing production of body fluids or nourishing Yin...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29343586/a-case-of-cardiomyopathy-due-to-premature-ductus-arteriosus-closure-the-flip-side-of-paracetamol
#17
Ingrid Anne Mandy Schierz, Mario Giuffrè, Ettore Piro, Simona La Placa, Giovanni Corsello
Paracetamol (acetaminophen or N-acetyl-p-aminophenol) is considered a safe analgesic and antipyretic nonsteroidal antiinflammatory drug commonly used during pediatric ages and during pregnancy. We report on a term neonate with closed ductus arteriosus, severe cardiomyopathy, right ventricular dysfunction, and functional stenosis of pulmonary arteries at birth after maternal self-medication with paracetamol and consumption of polyphenol-rich foods in late pregnancy. This drug, especially when associated with other vasoconstrictors (such as polyphenols), interferes with prostaglandin metabolism, which seriously accentuates the intrauterine ductus arteriosus constriction and leads to pharmacologic adverse events...
January 17, 2018: Pediatrics
https://www.readbyqxmd.com/read/29342983/assessing-the-perceptions-and-practice-of-self-medication-among-bangladeshi-undergraduate-pharmacy-students
#18
Md Omar Reza Seam, Rita Bhatta, Bijoy Laxmi Saha, Abhijit Das, Md Monir Hossain, S M Naim Uddin, Palash Karmakar, M Shahabuddin Kabir Choudhuri, Mohammad Mafruhi Sattar
Objectives: To evaluate the perceptions and extent of practicing self-medication among undergraduate pharmacy students. Methods: This cross-sectional, questionnaire-based study was conducted over a six month period (January to June 2016) among undergraduate pharmacy students in five reputable public universities of Bangladesh. It involved face-to-face interviews regarding self-medication of 250 respondents selected by simple random sampling. Results: Self-medication was reported by 88.0% of students. Antipyretics (58...
January 15, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29334933/temporary-exclusion-of-ill-children-from-childcare-centres-in-switzerland-practice-problems-and-potential-solutions
#19
Benjamin Sticher, Julia Bielicki, Christoph Berger
BACKGROUND: In childcare centres, temporary exclusion of ill children, if their illness poses a risk of spread of harmful diseases to others, is a central approach to fight disease transmission. However, not all ill children need to be excluded. Previous studies suggested that childcare centre staff have difficulties in deciding whether or not to exclude an ill child, even when official ill-child guidelines are used. We aimed to describe, quantify and analyse these ambiguities and discuss potential solutions...
January 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29327156/effectiveness-of-celecoxib-for-pain-relief-and-antipyresis-in-second-trimester-medical-abortions-with-misoprostol-a-randomized-controlled-trial
#20
Hatern Tintara, Peangpailin Voradithi, Thanapan Choobun
PURPOSE: To evaluate the effectiveness of celecoxib for pain relief and antipyresis during second trimester abortion using sublingual misoprostol. METHODS: Fifty-six pregnant women of gestational age 14-24 weeks were randomly assigned in a double-blind randomized controlled trial to receive 400 mg of celecoxib or placebo just before sublingual administration of misoprostol 400 µg every 6 h. Pain and body temperature (BT) were assessed every 1 h until the abortion or 24 h after the first dose of misoprostol...
January 11, 2018: Archives of Gynecology and Obstetrics
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