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Antipyretics

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https://www.readbyqxmd.com/read/28063412/spectral-characterisation-antiviral-activities-in-silico-admet-and-molecular-docking-of-the-compounds-isolated-from-tectona-grandis-to-chikungunya-virus
#1
Sangeetha K, Indu Purushothaman, Rajarajan S
Chikungunya infection is treated symptomatically with antipyretics and anti-inflammatory drugs without any specific antiviral drug till date. The lack of an approved antiviral drug and the emergence of virulent strains after 2006 epidemics emphasize the need for the development of potential antiviral drugs to Chikungunya virus. Hence, we studied the antiviral activity of the extracts and compounds isolated from Tectona grandis leaves to both the Asian and East central South African strains of Chikungunya virus...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28063133/a-clinical-and-safety-review-of-paracetamol-and-ibuprofen-in-children
#2
REVIEW
Dipak J Kanabar
The antipyretic analgesics, paracetamol, and non-steroidal anti-inflammatory agents NSAIDs are one of the most widely used classes of medications in children. The aim of this review is to determine if there are any clinically relevant differences in safety between ibuprofen and paracetamol that may recommend one agent over the other in the management of fever and discomfort in children older than 3 months of age.
January 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28058428/incorporation-of-aspirin-modulates-the-dynamical-and-phase-behavior-of-the-phospholipid-membrane
#3
V K Sharma, E Mamontov, M Ohl, M Tyagi
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used medications in the world for their analgesic, antipyretic, and anti-inflammatory actions, despite a well-known incidence of a wide spectrum of their adverse effects. To a great extent, beneficial action and side effects of NSAIDs are associated with the interaction of these drugs at the cell membrane level. Here, we use neutron scattering to combine elastic intensity scans, quasielastic and neutron spin echo (NSE) measurements to understand the effect of aspirin, a commonly used NSAID, on the dynamical and phase behavior of the membrane of dimyristoylphosphatidylcholine (DMPC), a prominent representative of phospholipids residing in the outer leaflet of the human erythrocyte membrane...
January 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28056333/-recommendation-for-the-prevention-and-treatment-of-non-steroidal-anti-inflammatory-drug-induced-gastrointestinal-ulcers-and-its-complications
#4
(no author information available yet)
Non-steroidal anti-inflammatory drugs (NSAIDs) are a broad class of non glucocorticoid drugs which are extensively used in anti-inflammatory, analgesic, and antipyretic therapies. However, NSAIDs may cause many side effects, most commonly in gastrointestinal(GI) tract. Cardiovascular system, kidney, liver, central nervous system and hematopoietic system are also involved. NSAID-induced GI side effects not only endanger the patients' health, increase mortality, but also greatly increase the cost of medical care...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28053893/bryophytes-hoard-of-remedies-an-ethno-medicinal-review
#5
REVIEW
Satish Chandra, Dinesh Chandra, Anupam Barh, Pankaj, Raj Kumar Pandey, Ishwar Prakash Sharma
Bryophytes are the second largest group of land plants after angiosperms. There is very less knowledge available about medicinal properties of these plants. Bryophytes are popular remedy among the tribal people of different parts of the world. Tribal people use these plants to cure various ailments in their daily lives. Bryophytes are used to cure hepatic disorders, skin diseases, cardiovascular diseases, used as antipyretic, antimicrobial, wound healing and many more other ailments by different tribal communities of Africa, America, Europe, Poland, Argentina, Australia, New Zealand, Turkey, Japan, Taiwan, Pakistan, China, Nepal and different parts of South, North and Eastern India...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28052238/anti-psoriatic-potential-of-solanum-xanthocarpum-stem-in-imiquimod-induced-psoriatic-mice-model
#6
Komal M Parmar, Prakash R Itankar, Apurva Joshi, Satyendra K Prasad
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) is one of the members of the dashamula (ten roots) in Ayurvedic system of medicine. The stem and fruits are used as an antipyretic, antiasthmatic and is prescribed in skin infections and for relief in burning sensation in the feet accompanied by vesicular eruptions. OBJECTIVE: To scientifically validate the anti-psoriatic potential of Solanum xanthocarpum stem in Imiquimod-induced psoriatic mice model MATERIALS AND METHODS: Ethanolic stems extract of Solanum xanthocarpum (ESX) was first subjected to phytochemical screening and quantification of identified phytoconstituents, which was further standardized with the help of HPTLC using chlorogenic acid as a marker...
January 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28042351/evaluating-community-pharmacy-practice-in-qatar-using-simulated-patient-method-acute-gastroenteritis-management
#7
Mohamed I Ibrahim, Subish Palaian, Fatima Al-Sulaiti, Somia El-Shami
OBJECTIVE: To evaluate Qatari pharmacists' prescribing, labeling, dispensing and counseling practices in response to acute community-acquired gastroenteritis. METHODS: The simulated patient method was used in this study. Thirty pharmacies in Doha were randomly selected and further randomized into two groups: Face-to-Face (n=15) vs. Telephone-call (n=15) per simulated patient; 2 simulated patients were involved. Prescribing, labeling, dispensing and counseling practices were assessed...
October 2016: Pharmacy Practice
https://www.readbyqxmd.com/read/28039625/the-influence-of-maternal-exposure-history-to-virus-and-medicine-during-pregnancy-on-congenital-heart-defects-of-fetus
#8
Qianhong Liang, Wei Gong, Dongming Zheng, Risheng Zhong, Yunjie Wen, Xiaodan Wang
Congenital heart disease (CHD) is the most common birth defect. It is due to dysfunction of the heart and great vessels during embryo development stage, or the channel was not closed after birth. This study focuses on investigating the influence of virus infection and medicine history during pregnancy on the incidence rate of CHD of fetus. We conducted a retrospective birth cohort study of infant born in the maternal and child health hospital of Fanyu district in Guangzhou. Five thousand three hundred eighty one cases with complete medical records, including mothers, fathers, and infants, were enrolled...
December 30, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28031961/fetal-origins-of-autism-spectrum-disorders-the-non-associated-maternal-factors
#9
REVIEW
Hind N Moussa, Anand Srikrishnan, Sean C Blackwell, Pramod Dash, Baha M Sibai
AIM: Several population-based studies have been conducted to determine whether maternal exposures are involved in the pathophysiology of autism spectrum disorder (ASD). We review these studies and describe the factors not associated with increased risk for ASD development. METHODS: We identified studies describing associations between maternal exposures and ASD development. These studies include the Childhood Autism Risks from Genetics and the Environment, Nurses' Health Study II, and the Swedish population registry...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28031152/lycopene-pretreatment-improves-hepatotoxicity-induced-by-acetaminophen-in-c57bl-6-mice
#10
Ana Carla Balthar Bandeira, Rafaella Cecília da Silva, Joamyr Victor Rossoni, Vivian Paulino Figueiredo, André Talvani, Silvia Dantas Cangussú, Frank Silva Bezerra, Daniela Caldeira Costa
Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice...
December 18, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28029072/secondary-metabolites-from-cissampelos-a-possible-source-for-new-leads-with-anti-inflammatory-activity
#11
Mateus Feitosa Alves, Marcus Tullius Scotti, Luciana Scotti, Francisco Jaime Bezerra Mendonça Junior, José Maria Barbosa Filho, Sílvia Adelaide Linhares de Melo, Sócrates Golzio Dos Santos, Margareth de Fátima Formiga Melo Diniz
The genus Cissampelos comprises 21 species which have a wide global distribution and various pharmacological activities such as analgesic and antipyretic, anti-inflammatory, anti-allergic, bronchodilation, and immunomodulation among others. Several compounds, mainly alkaloids with differing biological activities have been isolated from this genus. We will highlight antipyretic activities, anti-inflammatory, antiallergic, bronchodilatory, and immunomodulatory activities. In addition, we applied ligand-based-virtual screening associated with structure-based-virtual screening of a small dataset of 63 secondary metabolites from the Cissampelos genus of an in-house data bank, in order to select compounds with potential anti-inflammatory activity...
December 27, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27999605/fever-views-in-anthroposophic-medicine-and-their-scientific-validity
#12
REVIEW
David D Martin
Objective. To conduct a scoping review to characterize how fever is viewed in anthroposophic medicine (AM) and discuss the scientific validity of these views. Methods. Systematic searches were run in Medline, Embase, CAMbase, and Google Scholar. Material from anthroposophic medical textbooks and articles was also used. Data was extracted and interpreted. Results. Most of the anthroposophic literature on this subject is in the German language. Anthroposophic physicians hold a beneficial view on fever, rarely suppress fever with antipyretics, and often use complementary means of alleviating discomfort...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27992852/paracetamol-in-fever-in-critically-ill-patients-an-update
#13
REVIEW
D Chiumello, M Gotti, G Vergani
Fever, which is arbitrary defined as an increase in body temperature above 38.3°C, can affect up to 90% of patients admitted in intensive care unit. Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor α, interleukin 1, interleukin 6, and interferons). Fever is associated with increased length of stay in intensive care unit and with a worse outcome in some subgroups of patients (mainly neurocritically ill patients). Although fever can increase oxygen consumption in unstable patients, on the contrary, it can activate physiologic systems that are involved in pathogens clearance...
November 5, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27989879/bioassay-guided-isolation-of-cytotoxic-flavonoids-from-aerial-parts-of-coronopus-didymus
#14
Hafiza Noreen, Muhammad Farman, James S O McCullagh
ETHNOPHARMACOLOGICAL RELEVANCE: Coronopus didymus Linn. (Brassicaceae) is a medicinal plant used traditionally as antipyretic, expectorant, to purify blood and for alleviating symptoms of pain, inflammations, malaria, wounds and cancer. AIM OF THE STUDY: The present study was designed to isolate and identify the cytotoxic compounds responsible for anticancer activity from this traditionally useful medicinal plant. MATERIALS AND METHODS: Bioassay-guided fractionation of the ethanolic extract of aerial parts of C...
October 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27989618/pharmacokinetic-interactions-between-pelubiprofen-and-eperisone-hydrochloride-a-randomized-open-label-crossover-study-of-healthy-korean-men
#15
Ju-Hee Ryu, Joo-Il Kim, Hyung Son Kim, Gyu-Jeong Noh, Kyung-Tae Lee, Eun Kyoung Chung
PURPOSE: Pelubiprofen is a novel nonsteroidal anti-inflammatory, analgesic, and antipyretic drug with at least similar efficacy and better tolerability compared with other nonsteroidal anti-inflammatory, analgesic, and antipyretic drugs such as naproxen and aceclofenac. Eperisone hydrochloride is a centrally acting muscle relaxant that performs by blocking calcium channels. The combined use of pelubiprofen and eperisone hydrochloride is increasingly anticipated to promote the clinical effectiveness of pelubiprofen in relieving musculoskeletal symptoms of osteoarthritis, rheumatoid arthritis, and low back pain...
December 15, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27985284/drug-poisoning-in-the-community-among-children-a-nine-years-experience-from-a-tertiary-care-center-in-south-india
#16
Blessed Winston A, Debasis Das Adhikari, Saibal Das, Kaysina Vazhudhi, Aniket Kumar, Margaret Shanthi Fx, Indira Agarwal
OBJECTIVES: This study was performed to determine the incidence, demographic distribution, types and outcomes across various drug poisonings among children from south India. METHODS: This retrospective study included children less than 16 years who presented to the Pediatric Emergency Department with drug poisoning from the 1st of October 2004 to the 30th of September 2013. RESULTS: Out of the total 997 poisoning cases, 366 (36.71%) were contributed by drugs; mainly antiepileptics, central nervous system depressants, psychotropics, analgesic-antipyretics and natural drugs...
December 27, 2016: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/27982402/physical-methods-for-the-treatment-of-fever-in-critically-ill-patients-a-randomized-controlled-trial
#17
Patrícia de Oliveira Salgado, Ludmila Christiane Rosa da Silva, Priscila Marinho Aleixo Silva, Tânia Couto Machado Chianca
OBJECTIVE: To evaluate the effects of physical methods of reducing body temperature (ice pack and warm compression) in critically ill patients with fever. METHOD: A randomized clinical trial involving 102 adult patients with tympanic temperature ≥ 38.3°C of an infectious focus, and randomized into three groups: Intervention I - ice pack associated with antipyretic; Intervention II - warm compress associated with antipyretic; and Control - antipyretic. Tympanic temperature was measured at 15 minute intervals for 3 hours...
September 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27976165/cytotoxic-activities-against-two-lung-cancer-cells-of-thai-antipyretic-drug
#18
T Juckmeta, S Ruangnoo, A Itharat
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27958254/parental-beliefs-and-practices-regarding-childhood-fever-in-turkish-primary-care
#19
E Yavuz, E Yayla, S E Cebeci, E Kırımlı, R Ş Gümüştakım, L Çakır, S Doğan
BACKGROUND: Fever is a very common problem in pediatric age and is one of the most common reasons parents seek medical attention. We aimed to investigate beliefs, habits, and concerns of Turkish parents regarding their children's fever. MATERIALS AND METHODS: We performed a cross-sectional survey which was conducted as face-to-face interviews by family physicians from April to June 2014 in family healthcare centers in nine different cities in Turkey. Parents with a child with fever aged between 0 and 14 years were interviewed...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27956842/role-of-a-proprietary-propolis-based-product-on-the-wait-and-see-approach-in-acute-otitis-media-and-in-preventing-evolution-to-tracheitis-bronchitis-or-rhinosinusitis-from-nonstreptococcal-pharyngitis
#20
Francesco Di Pierro, Alberto Zanvit, Maria Colombo
Antipyretics and/or anti-inflammatory drugs along with a wait-and-see approach are the only treatments recommended in early acute otitis media (AOM) or viral pharyngitis. Propolis has been widely investigated for its antibacterial, antiviral, and anti-inflammatory properties and could perhaps be administered as an add-on therapy during watchful waiting in AOM or for better control of symptoms in nonstreptococcal pharyngitis. However, propolis has well-known problems of poor solubility and low oral bioavailability...
2016: International Journal of General Medicine
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