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Abdel-Hady El-Gilany, Fawzia El Sayed Abusaad
OBJECTIVES: To reveal mothers' beliefs about signs and symptoms associated with teething and their treatment practices. POPULATION AND METHODS: A cross-sectional study done in Mansoura District on 457 mothers and their children with one or more erupted teeth. Mothers were interviewed during vaccination session at 25 chosen health facilities. Mothers were asked whether they agree or disagree about 24 signs and symptoms claimed to be associated with teething. RESULTS: Only 1...
October 2017: Saudi Dental Journal
Thomas G de Leeuw, Maaike Dirckx, Antonia Gonzalez Candel, Gail P Scoones, Frank J P M Huygen, Saskia N de Wildt
Dipyrone has analgesic, spasmolytic, and antipyretic effects and is used to treat pain. Due to a possible risk of agranulocytosis with the use of dipyrone, it has been banned in a number of countries. The most commonly used data for the use of dipyrone are related to adults. Information relating to the use of dipyrone in children is scarce. Given the potential added value of dipyrone in the treatment of pain, a review of the literature was conducted to obtain more insight into the analgesic efficacy of dipyrone in children as well as the safety of dipyrone in terms of adverse events...
October 12, 2017: Paediatric Anaesthesia
Yahya Saleh Al-Awthan, Mohamed Ali Al-Duais, Amany Abdulfatah Hazeb, Waleed Ahmed Alril
OBJECTIVE: The present study investigated the influence of Achillea biebersteinii (Ab), a medicinal herb used widely in Yemeni's folk medicine as analgesic, antipyretic, against diarrhea and flatulence and for liver diseases, on the liver antioxidant potential of guinea pigs acutely intoxicated with dimethoate pesticide (DM). MATERIALS AND METHODS: Animals were administered with Ab aqueous extract (50 and 100 mg kg-1 b.wt., orally) or silymarin (100 mg kg-1 b.wt...
2017: Pakistan Journal of Biological Sciences: PJBS
Louis Jacob, Karel Kostev
OBJECTIVES: The goal of the present study was to analyze the prevalence of pain medication prescriptions in general practices in France, Germany, and the UK. METHODS: This study included all patients aged ≥18 years followed in 2016 in general practitioner practices in France, Germany and the UK. The primary outcome was the prevalence of patients receiving prescriptions for pain medications in France, Germany, and the UK in 2016. The following drugs were included in the analysis: anti-inflammatory and antirheumatic products, non-steroids and analgesics including opioids, antimigraine preparations, and other analgesics and antipyretics...
October 12, 2017: Postgraduate Medicine
Courtney E Nelson, Svetlana Ostapenko, Joseph J Zorc, Fran Balamuth
This retrospective cohort study aimed to describe antipyretic use among healthy patients in a pediatric emergency department (ED) with nonurgent fever defined as: triage level 4 or 5, chief complaint fever or temperature 38°C to 39°C, and otherwise normal vital signs, and determine if antipyretic administration is associated with increased ED length of stay (LOS). We compared continuous variables using Kruskal-Wallis and Wilcoxon rank sum testing. We adjusted confounding variables using logistic regression modeling...
October 1, 2017: Clinical Pediatrics
Shu-Ling Wang, Zhen-Kun Zhao, Jian-Feng Sun, Yun-Ting Sun, Xiao-Qing Pang, Zhao-Wu Zeng, Tian Xie
The chemical compositions of Anemone raddeana Rhizome, a kind of traditional Chinese medicine, were reviewed, along with its bioactivity and pharmacological properties and method improvements of extracting and detecting triterpenoid saponins. A. raddeana Rhizome is used to treat neuralgia and rheumatism, and is rich in triterpenoid saponins, most of which are pentacyclic, with oleanane as the nucleus. So far, 37 triterpenoid saponins have been determined from the herb. Its reported bioactivity and pharmacological properties have been described as anticancerous, antimicrobial, anti-inflammatory, analgesic, antipyretic, anticonvulsive, antihistaminic, and sedative...
October 6, 2017: Chinese Journal of Integrative Medicine
Mirjam J Eberhardt, Florian Schillers, Esther M Eberhardt, Linus Risser, Jeanne de la Roche, Christine Herzog, Frank Echtermeyer, Andreas Leffler
The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored the effects of these metabolites on the capsaicin receptor TRPV1, another redox-sensitive ion channel expressed in sensory neurons. Both pBQ and NAPQI, but not acetaminophen irreversibly activated and sensitized recombinant human and rodent TRPV1 channels expressed in HEK 293 cells...
October 6, 2017: Scientific Reports
A T Jannuzzi, M Kara, B Alpertunga
Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug in the world. However, hepatotoxicity caused by APAP overdose is the most frequent cause of acute liver failure worldwide and oxidative stress involved in the pathogenesis of APAP hepatotoxicity. Celastrol is a natural triterpenoid derived from Tripterygium wilfordii Hook F. that exhibits antioxidant, anti-inflammatory, and antitumor activities. In this study, we aimed to investigate the potential ameliorative effects of celastrol against APAP-induced cytotoxicity and oxidative stress...
January 1, 2017: Human & Experimental Toxicology
Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi
Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78...
April 10, 2017: Pharmacy (Basel, Switzerland)
Shiori Hasegawa, Haruna Hatahira, Misa Naganuma, Akari Shimauchi, Sayaka Sasaoka, Yumi Motooka, Akiho Fukuda, Junko Abe, Satoshi Nakao, Yamato Kato, Tomofumi Ohmori, Kazuhiro Iguchi, Mitsuhiro Nakamura
 OTC drugs play an important role in self-medication. OTC analgesic and antipyretic drugs are widely used in Japan. The present study aimed to survey the components of OTC drug package inserts for analgesic and antipyretic drugs and to evaluate the adverse event profiles using the Japanese Adverse Drug Event Report database (JADER). The JADER contains 430587 reports from between April 2004 and November 2016; a total of 750 reports of adverse events resulted from the use of OTC analgesic and antipyretic drugs...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Sofia Rakowsky, Henry A Spiller, Marcel J Casavant, Thiphalak Chounthirath, Nichole L Hodges, Eun Hye Kim, Gary A Smith
This study used the National Poison Data System database to retrospectively analyze the characteristics and medical outcomes of exposures to antipyretic medications involving children younger than 6 years in the United States. From 2000 through 2015, United States Poison Control Centers recorded an average of 74 387 antipyretic exposures annually among children younger than 6 years. Most exposures involved ibuprofen (55.1%) or acetaminophen (40.1%). From 2000 to 2009, the number of exposures increased by 73...
March 1, 2017: Clinical Pediatrics
Su Hye Lim, Eun Sang Jeon, Jeongyun Lee, Sang Yun Han, Han Chae
The purpose of this study was to review the pharmacognostic characteristics of Sasang type-specific medical herbs and suggest biological mechanisms that might be related to the personalized treatment of the East. Major compounds and their pharmacological activities of medical herbs for each Sasang types were systematically reviewed. The pharmacognostic characteristics of its main compounds were systematically analyzed with previous studies and three web-based databases. Sasang type-specific medical herbs were selected, and biological effects of their phytochemicals were reviewed from the pathophysiological features of each Sasang types...
September 2017: Integrative medicine research
M Koné, T Diallo, A Dénou, B F Coulibaly, B Dackouo, B Coulibaly, B Y Koumaré, A Maiga
The aim of our study was to investigate the quality of information about pharmaceutical products in Mali. The study surveyed 98 prescribers, 60 pharmacists, and the package inserts of a basket of 30 generic medicines, compared to those of the corresponding proprietary versions. We made a rational choice of 98 doctors from various specialties and levels of the health system and randomly selected 60 of the 215 pharmacies in the district of Bamako (Mali). A rational sampling of generic medicines provided us with a basket of 30 drug notices for the antimalarial, antibiotic, antalgic, antipyretic, and anti-inflammatory agents used most in the Republic of Mali...
August 1, 2017: Médecine et Santé Tropicales
Pier Luigi Calvo, Francesco Tandoi, Tobias B Haak, Andrea Brunati, Michele Pinon, Dominic Dell Olio, Renato Romagnoli, Marco Spada
BACKGROUND: Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes. Yet, as acetaminophen is routinely used in febrile illnesses, it may be mistakenly held responsible for the acute liver damage. CASE PRESENTATION: An 11 month old boy had been on acetaminophen for 10 days (total dose 720 mg = 72 mg/kg) when he developed acute-liver-failure with encephalopathy...
September 25, 2017: Italian Journal of Pediatrics
Minho Moon, Eugene Huh, Wonil Lee, Eun Ji Song, Deok-Sang Hwang, Tae Hee Lee, Myung Sook Oh
Heat stress conditions lead to neuroinflammation, neuronal death, and memory loss in animals. Coptidis Rhizoma (CR) exhibits potent fever-reducing effects and has been used as an important traditional medicinal herb for treating fever. However, to date, the effects of antipyretic CR on heat-induced brain damages have not been investigated. In this study, CR significantly reduced the elevation of ear and rectal temperatures after exposure to heat in mice. Additionally, CR attenuated hyperthermia-induced stress responses, such as release of cortisol into the blood, and upregulation of heat shock protein and c-Fos in the hypothalamus and hippocampus of mice...
September 23, 2017: Nutrients
Bo Zhang, Tie-Gui Nan, Zhi-Lai Zhan, Li-Ping Kang, Jian Yang, Chang-Jiang-Sheng Lai, Yuan Yuan, Bao-Min Wang, Lu-Qi Huang
The edible flower buds of honeysuckle are traditionally used as herbal medicine or food additives in China. Chlorogenic acid (CGA) serves as the quality control marker of honeysuckle for its high content and antipyretic property. In this paper, a specific monoclonal antibody (mAb2E2) against CGA was produced. After optimization, mAb2E2-based indirect competitive enzyme-linked immunosorbent assay (icELISA) was developed. The concentrations of CGA producing 50% inhibition and the calibration range of the icELISA were 0...
September 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
Anwesha A Mukherjee, Amit D Kandhare, Subhash L Bodhankar
BACKGROUND: Madhuca indica J. F. Gmel. (Sapotaceae) is widely used ethnobotanically as anti-diabetic, antipyretic, hepatoprotective, anti-inflammatory and analgesic. It was shown to possess potent anti-apoptotic property. THE AIM OF THE STUDY: To evaluate the possible mechanism of action of isolated phytoconstituent from Madhuca indica Leaves methanolic extract (MI-ALC) on arsenic-induced cardiotoxicity in rats. MATERIALS AND METHODS: The 3,5,7,3',4'-Pentahydroxy flavone (QTN) was isolated and characterized by using HPTLC, (1)H NMR, and LC-MS from MI-ALC...
September 1, 2017: Environmental Toxicology and Pharmacology
Mohd Iqbal Yatoo, Umesh Dimri, Arumugam Gopalakrishnan, Kumaragurubaran Karthik, Marappan Gopi, Rekha Khandia, Mani Saminathan, Archana Saxena, Mahmoud Alagawany, Mayada Ragab Farag, Ashok Munjal, Kuldeep Dhama
Pedicularis plants (Orobanchaceae), popularly known as lousewort, are found in Asia, Europe, and North America, and have been used in Sowa-Rigpa, the Himalayan art of healing and a traditional system of medicine for treating various ailments in humans. A comprehensive compilation on this valuable medicinal plant is not available, however. The present extensive review provides insight into the salient medicinal properties of Pedicularis plants with respect to various health issues and diseases. Our previous studies on Pedicularis plants from the Changthang region of Ladakh (India) and research advances leading to new developments in this field have prompted this review...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mahesh Chandra, Om Prakash, Ravendra Kumar, Rakesh Kumar Bachheti, Brij Bhushan, Mahesh Kumar, Anil Kumar Pant
Background:Callicarpa macrophylla (Varbenaceae) is a medicinal shrub and is traditionally used in India, China, and South Asia. Methods: The plant material was collected from lower Himalayan region of Uttarakhand in India. The essential oils from three different aerial parts were analyzed by GC-MS. Antioxidant activity, phenolic assay, and various pharmacological activities were determined by using existing methods which are generally practiced widely. Results: Over 51, 53, and 40 compounds were identified in C...
July 10, 2017: Medicines (Basel, Switzerland)
H C Park, M J Kim, B H Lee
BACKGROUND: Uncomplicated appendicitis may resolve spontaneously or require treatment with antibiotics or appendicectomy. The aim of this randomized trial was to compare the outcome of a non-antibiotic management strategy with that of antibiotic therapy in uncomplicated appendicitis. METHODS: Patients presenting to a university teaching hospital with CT-verified uncomplicated simple appendicitis (appendiceal diameter no larger than 11 mm and without any signs of perforation) were randomized to management with a no-antibiotic regimen with supportive care (intravenous fluids, analgesia and antipyretics as necessary) or a 4-day course of antibiotics with supportive care...
September 19, 2017: British Journal of Surgery
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