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Antipyretics

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https://www.readbyqxmd.com/read/27927089/an-evaluation-of-the-anti-inflammatory-antipyretic-and-analgesic-effects-of-hydroethanol-leaf-extract-of-albizia-zygia-in-animal-models
#1
Wonder Kofi Mensah Abotsi, Stanley Benjamin Lamptey, Stephen Afrane, Eric Boakye-Gyasi, Ruth Uwa Umoh, Eric Woode
CONTEXT: The leaves of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) are used in Ghanaian traditional medicine for the treatment of pain, inflammatory disorders and fever (including malaria). OBJECTIVES: The present study evaluated the anti-inflammatory, antipyretic and analgesic effects of the hydroethanol leaf extract of Albizia zygia (AZE) in animal models. MATERIALS AND METHODS: The anti-inflammatory and antipyretic effects of AZE were examined in the carrageenan-induced foot oedema model and the baker's yeast-induced pyrexia test respectively...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27917785/dipyrone-ameliorates-behavioural-changes-induced-by-unpredictable-chronic-mild-stress-gender-differences
#2
Olcay E Kiroğlu, Kübra E Demirkol, Fatih Berktaş, Arash A Yegani, Ayşegül Kirpik, Erkan Maytalman, Mahmut Ünverdi, Fazilet Aksu
PURPOSE: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects. METHODS: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27916764/serotonergic-system-does-not-contribute-to-the-hypothermic-action-of-acetaminophen
#3
Akihiro Fukushima, Wakana Sekiguchi, Kizuku Mamada, Yumi Tohma, Hideki Ono
Acetaminophen (AcAP), a widely-used antipyretic and analgesic drug, has been considered to exert its effects via central mechanisms, and many studies have demonstrated that the analgesic action of AcAP involves activation of the serotonergic system. Although the serotonergic system also plays an important role in thermoregulation, the contribution of serotonergic activity to the hypothermic effect of AcAP has remained unclear. In the present study, we examined whether the serotonergic system is involved in AcAP-induced hypothermia...
December 3, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27898629/influenza-like-illness-diagnosis-and-management-in-the-acute-care-setting
#4
Sharon G Humiston, Thuylinh N Pham
During influenza season, acute respiratory illness due to influenza is difficult to distinguish from other influenza-like illnesses, but testing should be reserved for situations when timely results will influence management or infection control measures. Immunization status and timing of disease onset notwithstanding, a neuraminidase inhibitor should be offered immediately for certain high-risk children; neuraminidase inhibitor treatment should be considered if shorter illness is warranted or an at-risk sibling may be protected...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27898459/characterization-of-the-adverse-effects-induced-by-acetaminophen-and-non-steroidal-anti-inflammatory-drugs-based-on-the-analysis-of-the-japanese-adverse-drug-event-report-database
#5
Junko Nagai, Yoshihiro Uesawa, Ryotaro Shimamura, Hajime Kagaya
OBJECTIVES: Acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are antipyretic analgesics with established adverse effects; however, only a few studies have compared their adverse effects simultaneously. We aimed to compare the adverse effects of these medications to confirm the respective frequencies of both rare and major adverse effects. METHODS: We used a high-quality database for spontaneous adverse drug event reporting in Japan. Data were extracted regarding the adverse effects of acetaminophen and NSAIDs to compare the tendency of the appearance of those adverse effects between the drugs...
November 24, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27885462/the-cytoprotective-effect-of-rumex-aquaticus-herba-extract-against-hydrogen-peroxide-induced-oxidative-stress-in-ags-cells
#6
Eun Jeong Cho, Seung In Um, Jeong Hoon Han, Byeonghee Kim, Sang Beom Han, Ji Hoon Jeong, Hak Rim Kim, Inkyeom Kim, Wan Kyun Whang, Eunhwa Lee, Uy Dong Sohn
The Rumex Aquaticus Herba extract containing quercetin-3-β-D-glucuronopyranoside (ECQ) has been reported to exhibit various pharmacological activities, including anti-inflammatory and anti-oxidative effects. This plant has been traditionally used for the treatment of diarrhea, disinfestation, edema and jaundice, and as an antipyretic drug. The aim of the present study was to investigate the ability of ECQ to protect against oxidative damage and to determine its signaling mechanism in AGS cells. The protein expressions of heme oxygenase-1 (HO-1) and nuclear factor-erythroid 2 related factor 2 (Nrf2) were measured by Western blots...
November 24, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27884143/the-using-of-a-piglets-as-a-model-for-evaluating-the-dipyrone-hematological-effects
#7
Artur Burmańczuk, Andrzej Milczak, Tomasz Grabowski, Monika Osypiuk, Cezary Kowalski
BACKGROUND: Dipyrone (MET, metamizole) is a non-steroidal anti-inflammatory drug commonly used both in human and in veterinary medicine. After oral administration, is broken down rapidly to metabolites which largely retain the activity of the parent drug. Its metabolites have analgesic, antipyretic and anti-inflammatory effects. RESULTS: The subjects were eight healthy male Large White post-suckling piglets, weighing between 5.0 to 7.4 kg, of ages 35 ± 10 days...
November 25, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27875921/a-retrospective-review-of-paediatric-adverse-drug-reactions-reported-in-lombardy-and-croatia-from-2005-to-2013
#8
Carla Carnovale, Marta Gentili, Marco Matacena, Marina Dimov Di Giusti, Darko Krnic, Barbara Dolinic, Darija Kolaric, Zeljana Margan Koletic, Viola Macolic Sarinic, Maja Culjak, Ida Fortino, Luca Merlino, Emilio Clementi, Sonia Radice
OBJECTIVE: to characterise the adverse drugs reactions (ADRs) reported in the Lombard and Croatian paediatric population and to compare data to specific paediatric age groups, in terms of trend, pattern and severity of ADRs, increasing understanding of paediatric ADRs. RESEARCH DESIGN AND METHODS: We selected and analysed all the spontaneous reports in which children were involved (0 < 18 years old) reported in the Lombardy and in Croatian pharmacovigilance databases from 1(th) March 2005 to 31(th) December 2013...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27872357/antipyretic-efficacy-and-safety-of-ibuprofen-versus-acetaminophen-suspension-in-febrile-children-results-of-2-randomized-double-blind-single-dose-studies
#9
Shyamalie Jayawardena, David Kellstein
Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27871974/anti-inflammatory-sesquiterpene-lactones-from-onopordum-illyricum-l-asteraceae-an-italian-medicinal-plant
#10
Carmen Formisano, Cinzia Sanna, Mauro Ballero, Giuseppina Chianese, Carmina Sirignano, Daniela Rigano, Estrella Millán, Eduardo Muñoz, Orazio Taglialatela-Scafati
Onopordum illyricum L. is a medicinal plant used in the Mediterranean area as antipyretic for the treatment of respiratory and urinary inflammations and to treat skin ulcers. Repeated chromatographic purification of O. illyricum aerial parts led to the isolation of six known sesquiterpenes, which were evaluated for the inhibition of the pro-inflammatory transcription factors NF-κB and STAT3 and for the activation of the transcription factor Nrf2, which regulates the cellular antioxidant response. Structure-activity relationships were interpreted by the NMR-based cysteamine assay...
November 19, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27862959/understanding-zika-virus
#11
John S Murray
PURPOSE: This article describes what pediatric healthcare professionals should know about Zika virus (ZIKV). LITERATURE REVIEW: ZIKV is classified as an arthropod-borne, single-stranded RNA virus of the Flaviviridae family and genus Flavivirus. ZIKV is not new. The virus was first discovered almost 70 years ago in Uganda. The first isolate of the virus was found in rhesus monkeys in the Zika Forrest, hence the nomenclature. The primary route of ZIKV transmission to humans is through the bite of an infected Aedes species mosquito-primarily Aedes aegypti...
November 9, 2016: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/27860201/peptidome-characterization-of-the-antipyretic-fraction-of-bubali-cornu-aqueous-extract-by-nano-liquid-chromatography-with-orbitrap-mass-spectrum-detection
#12
Rui Liu, Qiong Huang, Jin-Ao Duan, Zhenhua Zhu, Pei Liu, Yong Bian, Jinhua Tao, Dawei Qian
In the present study, the antipyretic activity of Bubali Cornu (water buffalo horn) fraction and its metabolomics were investigated. The fraction decreased rat rectal temperature, and 13 endogenous metabolites were identified as potential biomarkers. Selected metabolites were involved in arachidonic acid metabolism and glycerophospholipid metabolism etc. Following treatment with the fraction, four metabolites, pyroglutamic acid, palmitelaidic acid, leukotriene A4, and prostaglandin A2 were reversed. In addition, the levels of interleukin-1β, tumor necrosis factor-α, prostaglandin E2 , and cyclic adenosine monophosphate in plasma were also reversed after treatment as determined by enzyme linked immunosorbent assay...
November 9, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27855095/psychotropic-drug-use-and-alcohol-consumption-among-older-adults-in-germany-results-of-the-german-health-interview-and-examination-survey-for-adults-2008-2011
#13
Yong Du, Ingrid-Katharina Wolf, Hildtraud Knopf
OBJECTIVES: The use and combined use of psychotropic drugs and alcohol among older adults is a growing public health concern and should be constantly monitored. Relevant studies are scarce in Germany. Using data of the most recent national health survey, we analyse prevalence and correlates of psychotropic drug and alcohol use among this population. METHODS: Study participants were people aged 60-79 years (N=2508) of the German Health Interview and Examination Survey for Adults 2008-2011...
October 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27853679/russian-olive-elaeagnus-angustifolia-as-a-herbal-healer
#14
REVIEW
Zeinab Amiri Tehranizadeh, Ali Baratian, Hossein Hosseinzadeh
Introduction:Elaeagnus spp. is one in the family of riparian trees growing near the rivers or water corridors. In this family, Elaeagnus angustifolia (Russian olive) is famous because of its medical applications. Methods: A comprehensive review was performed to extract the related data from published literature. Results: Traditionally, it has been used as an analgesic, antipyretic and diuretic herbal medicine. A large number of compounds have been derived from Russian olive and made this plant a source of flavonoids, alkaloids, minerals and vitamins...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27851037/1401-antipyretic-therapy-in-critically-ill-septic-patients-a-systematic-review-and-meta-analysis
#15
Anne Drewry, Enyo Ablordeppey, Ellen Murray, Carolyn Stoll, Sonya Izadi, Catherine Dalton, Brian Fuller, Graham Colditz
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27843305/does-the-use-of-acetylsalicylic-acid-have-an-influence-on-our-vision
#16
REVIEW
Katarzyna Michalska-Małecka, Agnieszka Regucka, Dorota Śpiewak, Magdalena Sosnowska-Pońska, Alfred Niewiem
PURPOSE: Acetylsalicylic acid (ASA) is one of the most commonly used drugs in the world due to its anti-inflammatory, analgesic, and antipyretic properties. This review aims to describe the relationship between acetylsalicylic acid and age-related macular degeneration (AMD) - a chronic disease that causes deterioration of visual acuity and is one of the most common ophthalmological diseases these days. METHODS: Data presented in this review were collected from both research and review articles concerning ophthalmology and pharmacology...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27825318/prevalence-of-malaria-typhoid-toxoplasmosis-and-rubella-among-febrile-children-in-cameroon
#17
Olivia A Achonduh-Atijegbe, Kenji O Mfuh, Aristid H E Mbange, Jean P Chedjou, Diane W Taylor, Vivek R Nerurkar, Wilfred F Mbacham, Rose Leke
BACKGROUND: The current roll-out of rapid diagnostic tests (RDTs) in many endemic countries has resulted in the reporting of fewer cases of malaria-attributed illnesses. However, lack of knowledge of the prevalence of other febrile illnesses and affordable diagnostic tests means that febrile patients are not managed optimally. This study assessed the prevalence of commonly treatable or preventable febrile illnesses in children between 6 months and 15 years using rapid diagnostic tests at the point-of-care...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27823839/analytical-challenges-in-the-confirmative-identification-of-dipyrone-as-an-adulterant-in-illicit-drug-samples
#18
Richard C A Isaacs, Michaela M Harper, Emily C Miller
Dipyrone is an analgesic and antipyretic drug that is sometimes encountered as an adulterant in illicit drug samples, particularly illicit fentanyl containing samples. It undergoes thermal decomposition to aminopyrine and 4-methylaminoantipyrine during analysis via gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). During analysis via high pressure liquid chromatography (HPLC) and high pressure liquid chromatography-mass spectrometry (HPLC-MS), it undergoes hydrolytic decomposition solely to 4-methylaminoantipyrine...
August 24, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27822946/the-association-of-fever-with-total-mechanical-ventilation-time-in-critically-ill-patients
#19
Dong Won Park, Moritoki Egi, Masaji Nishimura, Youjin Chang, Gee Young Suh, Chae Man Lim, Jae Yeol Kim, Keiichi Tada, Koichi Matsuo, Shinhiro Takeda, Ryosuke Tsuruta, Takeshi Yokoyama, Seon Ok Kim, Younsuck Koh
This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study. We included mechanically ventilated patients for more than 24 hours from 10 Korean and 15 Japanese intensive care units (ICU), and recorded maximal body temperature under the support of mechanical ventilation (MAX(MV)). To assess the independent association of MAX(MV) with TVT, we used propensity-matched analysis in a total of 769 survived patients with medical or surgical admission, separately...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27812900/leucas-aspera-nanomedicine-shows-superior-toxicity-and-cell-migration-retarded-in-prostate-cancer-cells
#20
Anjusha Mohan, Shantikumar V Nair, Vinoth-Kumar Lakshmanan
Prostate cancer is one of the most common malignancies among men worldwide. The main aim of the present work was to clarify the advantages of a nanoformulation of ayurvedic herbal plants. Specifically, we assessed the improved anticancer activity of Leucas aspera nanoparticles compared with methanolic crude extract in PC3 prostate cancer cells and normal cells. L. aspera is a plant that is used in ayurveda due to the antirheumatic, antipyretic, anti-inflammatory, antibacterial, anticancer, and cytotoxic activities...
November 3, 2016: Applied Biochemistry and Biotechnology
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