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https://www.readbyqxmd.com/read/28332176/a-naphthoquinone-from-sinningia-canescens-inhibits-inflammation-and-fever-in-mice
#1
Luís A Lomba, Paulo H Vogt, Victor E P Souza, Mariane C G Leite-Avalca, Maria H Verdan, Maria Elida A Stefanello, Aleksander R Zampronio
We previously showed that plants from the genus Sinningia are a source of antiinflammatory and analgesic compounds with different mechanisms of action. The present study evaluated the antiinflammatory, antinociceptive, and antipyretic effects of a crude extract (CE) from Sinningia canescens, its fractions, and 6-methoxy-7-hydroxy-α-dunnione (MHD) in mice. These effects were evaluated using carrageenan (Cg)-induced paw edema, acetic acid- and formalin-induced nociception, mechanical hyperalgesia, lipopolysaccharide (LPS)-induced fever, and plasma cytokine levels...
March 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28330081/emerging-cam-ziziphus-nummularia-with-in-vivo-sedative-hypnotic-antipyretic-and-analgesic-attributes
#2
Abdur Rauf, Jawad Ali, Haroon Khan, Mohammad S Mubarak, Seema Patel
Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer's yeast-induced hyperthermia and acetic acid-induced writhing experiments. The significance of the outcomes was analyzed with statistical tests...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328895/side-effects-of-pain-and-analgesia-in-animal-experimentation
#3
REVIEW
Paulin Jirkof
This review highlights selected effects of untreated pain and of widely used analgesics such as opioids, non-steroid anti-inflammatory drugs and antipyretics, to illustrate the relevance of carefully planned, appropriate and controlled analgesia for greater reproducibility in animal experiments involving laboratory rodents.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28323046/centaurium-erythraea-methanol-extract-protects-red-blood-cells-from-oxidative-damage-in-streptozotocin-induced-diabetic-rats
#4
Miloš Đorđević, Mirjana Mihailović, Jelena Arambašić Jovanović, Nevena Grdović, Aleksandra Uskoković, Anja Tolić, Marija Sinadinović, Jovana Rajić, Danijela Mišić, Branislav Šiler, Goran Poznanović, Melita Vidaković, Svetlana Dinić
ETHNOPHARMACOLOGICAL RELEVANCE: Centaurium erythraea Rafn (CE) is a traditional medicinal herb in Serbia with antidiabetic, digestive, antipyretic and antiflatulent effects. AIM OF THE STUDY: To investigate the potential protective effects of the methanol extract of the aerial parts of CE against glyco-oxidative stress in red blood cells (RBCs) in rats with experimentally induced diabetes. MATERIAL AND METHODS: Diabetes was induced in Wistar rats by intraperitoneal (i...
March 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28321277/clinical-outcomes-among-febrile-children-aged-2-to-59-months-with-negative-malaria-rapid-diagnostic-test-results-in-mchinji-district-malawi
#5
Dyson Mwandama, Chawanangwa Mwale, Andrew Bauleni, Themba Phiri, Joseph Chisaka, Humphreys Nsona, Don P Mathanga
BACKGROUND: Malawi malaria treatment guidelines recommend a definitive diagnosis, using a malaria rapid diagnostic test (mRDT), for all patients with fever or history of fever. Improving the management and outcomes of febrile children with negative mRDT results should be a priority. METHODS: Through a prospective cohort study designed to investigate clinical outcomes of children treated at the community level, we followed, for 7 days, children aged 2 to 59 months, who had negative mRDT results and were treated with antipyretic medication...
December 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28306590/the-use-of-dipyrone-in-the-icu-is-associated-with-acute-kidney-injury-a-retrospective-cohort-analysis
#6
Thomas Stueber, Laura Buessecker, Andreas Leffler, Hans-Jörg Gillmann
BACKGROUND: Use of dipyrone (metamizole) in perioperative and ICU pain therapy remains controversial due to a lack of solid evidence weighing dipyrone benefit against its potential life-threatening complications. Although dipyrone has known analgesic and antipyretic properties, its mechanisms of actions are incompletely understood. Although dipyrone effects on renal vasodilator prostaglandin synthesis are documented, little is known about its potential renal side effects, especially in the critical care environment...
March 16, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28302201/-risk-factors-for-allergic-diseases-in-children-aged-0-24-months-in-the-wuhu-urban-area-anhui-province-china
#7
Shou-Gui Wang, Xiang-Sheng Zhang, Yan-Fang Zhao, Li Sun, Xi-Tao Pan, Ning Wan
OBJECTIVE: To investigate the prevalence of allergic diseases in children aged 0-24 months in the Wuhu urban area of Anhui Province and risk factors for allergic diseases. METHODS: Cluster random sampling was performed to select 600 children aged 0-24 months and their mothers from the Wuhu urban area, and a questionnaire survey was conducted to collect the data of disease history, family history, mothers' conditions during pregnancy, and child-rearing situation...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28290314/acute-and-subacute-oral-toxicity-assessment-of-the-oil-extracted-from-attalea-phalerata-mart-ex-spreng-pulp-fruit-in-rats
#8
Fernando Freitas de Lima, Giseli Karenina Traesel, Sara Emilia Lima Tolouei Menegati, Ariany Carvalho Dos Santos, Roosevelt Isaias Carvalho Souza, Vinícius Soares de Oliveira, Eliana Janet Sanjinez-Argandoña, Claudia Andrea Lima Cardoso, Silvia Aparecida Oesterreich, Maria do Carmo Vieira
Attalea phalerata Mart. ex Spreng., popularly known as "bacuri", is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407...
January 2017: Food Research International
https://www.readbyqxmd.com/read/28288826/evaluation-of-acute-and-subacute-toxicity-of-hydroethanolic-extract-of-dolichandra-unguis-cati-l-leaves-in-rats
#9
Juliana Calil Brondani, Fernanda Ziegler Reginato, Evelyne da Silva Brum, Marina de Souza Vencato, Cibele Lima Lhamas, Carine Viana Silva, Maria Izabel Ugalde Marques da Rocha, Liliane de Freitas Bauermann, Melânia Palermo Manfron
ETHNOPHARMACOLOGICAL RELEVANCE: Dolichandra unguis-cati L. is a native climbing plant of Brazil, popularly known as "unha de gato". It has been traditionally used mainly as an antipyretic, anti-inflammatory and anti-tumor agent, yet little toxicological information is found in the literature. AIM OF THE STUDY: To identify the chemical composition of the hydroethanolic extract obtained from the leaves of Dolichandra uniguis-cati and to evaluate the acute and subacute toxicity in male and female rats, in order to assess the safety profile of this plant...
March 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28288619/medication-related-calls-received-by-a-national-telenursing-triage-and-advice-service-in-australia-a-retrospective-cohort-study
#10
Ling Li, Rebecca Lake, Magdalena Z Raban, Mary Byrne, Maureen Robinson, Johanna Westbrook, Melissa T Baysari
BACKGROUND: Telenursing triage and advice services are increasingly being used to deliver health advice. Medication-related queries are common, however little research has explored the medication-related calls made to these services. The aim of this study was to examine the profile of medication-related calls to a national telenursing triage and advice service and the medications involved. METHODS: This was a retrospective cohort study of medication-related calls received by Australia's national helpline (healthdirect helpline) in 2014, which provides free advice from registered nurses...
March 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28282294/in-vivo-analgesic-antipyretic-and-anti-inflammatory-potential-of-leaf-extracts-and-fractions-of-eria-javanica
#11
N M Mahmudul Alam Bhuiya, Mahmud Hasan, Zobaer Al Mahmud, Nazmul Qais, Mohammad Shah Hafez Kabir, Farhan Ahmed, Mir Muhammad Nasir Uddin
Background The objective of the study was to evaluate the antinociceptive, antipyretic and anti-inflammatory activities of ethanolic extract, methanolic extract and n-hexane and chloroform-soluble fractions of methanolic extract of Eria javanica leaves in animal model (rat and mice). Methods The anti-nociceptive potentials of the extracts were studied using the acetic acid-induced writhing test in mice and the antipyretic activity was investigated using yeast-induced pyrexia in rats. Anti-inflammatory activity test was done on rats at a dose by using carrageenan-induced paw edema test...
March 1, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28280312/self-medication-practice-in-ethiopia-a-systematic-review
#12
REVIEW
Mohammed Biset Ayalew
BACKGROUND: Self-medication patterns vary among different populations, and are influenced by many factors. No review has been done that comprehensively expresses self-medication practice in Ethiopia. The aim of this study was to provide an overview of the literature on self-medication practice in Ethiopia. MATERIALS AND METHODS: Databases (PubMed, Google Scholar, ResearchGate, and Hinari) were searched for published studies on the practice of self-medication in Ethiopia without restriction in the year of publication or methodology...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28271158/physicians-perspectives-on-the-diagnosis-and-management-of-periodic-fever-aphthous-stomatitis-pharyngitis-and-cervical-adenitis-pfapa-syndrome
#13
Kalpana Manthiram, Suzanne C Li, Jonathan S Hausmann, Gil Amarilyo, Karyl Barron, Hanna Kim, Simona Nativ, Geraldina Lionetti, Andrew Zeft, Donald Goldsmith, David Kimberlin, Kathryn Edwards, Fatma Dedeoglu, Sivia Lapidus
To assess the practice patterns of pediatric rheumatology and infectious diseases subspecialists in the diagnosis and treatment of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. An online survey assessing diagnostic and treatment approaches was sent to 424 members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) and 980 members of the Pediatric Infectious Disease Society (PIDS). 277 physicians (123 from CARRA and 154 from PIDS representing 21% of the total membership) completed the survey...
March 7, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28262330/a-randomized-study-of-fever-prophylaxis-and-the-immunogenicity-of-routine-pediatric-vaccinations
#14
Jacek Wysocki, Kimberly J Center, Jerzy Brzostek, Ewa Majda-Stanislawska, Henryk Szymanski, Leszek Szenborn, Hanna Czajka, Barbara Hasiec, Jerzy Dziduch, Teresa Jackowska, Anita Witor, Elżbieta Kopińska, Ryszard Konior, Peter C Giardina, Vani Sundaraiyer, Scott Patterson, William C Gruber, Daniel A Scott, Alejandra Gurtman
OBJECTIVE: Prophylactic antipyretic use during pediatric vaccination is common. This study assessed whether paracetamol or ibuprofen prophylaxis interfere with immune responses to the 13-valent pneumococcal conjugate vaccine (PCV13) given concomitantly with the combined DTaP/HBV/IPV/Hib vaccine. METHODS: Subjects received prophylactic paracetamol or ibuprofen at 0, 6-8, and 12-16 h after vaccination, or 6-8 and 12-16 h after vaccination at 2, 3, 4, and 12months of age...
March 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28260522/medicinal-and-healthical-applications-of-tinospora-cordifolia-guduchi-a-miraculous-herb-countering-various-diseases-disorders-and-potentials-as-an-immune-booster
#15
Kuldeep Dhama Dhama, Swati Sachan, Rekha Khandia, Ashok Munjal, Hafiz M N Iqbal, Shyma K Latheef, Kumaragurubaran Karthik, Hari Abdul Samad, Ruchi Tiwari, Maryam Dadar
BACKGROUND: Plants have been known as an integral part of traditional medicine because of their phytoconstituents with their miraculous substances. Tinospora cordifolia (Guduchi/Giloy) is one such plant having pharmacological functions and medicinal values due to its several constituents such as terpenes, glycosides, alkaloids, steroids and flavonoids. Thus, it has been rightly mentioned in old texts as "Amrita". OBJECTIVE: The objective of the present review is to extend the current knowledge, importance and beneficial pharmacological applications of Guduchi in humans for safeguarding various health issues...
February 28, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28225210/prophylactic-drug-management-for-febrile-seizures-in-children
#16
REVIEW
Martin Offringa, Richard Newton, Martinus A Cozijnsen, Sarah J Nevitt
BACKGROUND: Febrile seizures occurring in a child older than one month during an episode of fever affect 2% to 4% of children in Great Britain and the United States and recur in 30%. Rapid-acting antiepileptics and antipyretics given during subsequent fever episodes have been used to avoid the adverse effects of continuous antiepileptic drugs. OBJECTIVES: To evaluate primarily the effectiveness and safety of antiepileptic and antipyretic drugs used prophylactically to treat children with febrile seizures; but also to evaluate any other drug intervention where there was a sound biological rationale for its use...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28223869/compatibility-study-of-paracetamol-chlorpheniramine-maleate-and-phenylephrine-hydrochloride-in-physical-mixtures
#17
G G G de Oliveira, A Feitosa, K Loureiro, A R Fernandes, E B Souto, P Severino
Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1:1)...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28221185/antipyretic-therapy-in-critically-ill-septic-patients-a-systematic-review-and-meta-analysis
#18
Anne M Drewry, Enyo A Ablordeppey, Ellen T Murray, Carolyn R T Stoll, Sonya R Izadi, Catherine M Dalton, Angela C Hardi, Susan A Fowler, Brian M Fuller, Graham A Colditz
OBJECTIVE: This meta-analysis aimed to examine the impact of antipyretic therapy on mortality in critically ill septic adults. DATA SOURCES: Literature searches were implemented in Ovid Medline, Embase, Scopus, Cumulative Index of Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, NHS Economic Evaluation Database, and ClinicalTrials.gov through February 2016. STUDY SELECTION: Inclusion criteria were observational or randomized studies of septic patients, evaluation of antipyretic treatment, mortality reported, and English-language version available...
February 17, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28219765/maternal-dipyrone-treatment-during-lactation-in-mice-reduces-maternal-behavior-and-increases-anxiety-like-behavior-in-offspring
#19
Vanessa Barbosa Veronesi, Tatiane Helena Batista, Ana Cláudia Alves Freire Ribeiro, Alexandre Giusti-Paiva, Fabiana Cardoso Vilela
Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam's maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9...
May 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28216902/feeble-antipyretic-analgesic-and-anti-inflammatory-activities-were-found-with-regular-dose-4-o-%C3%AE-d-glucosyl-5-o-methylvisamminol-one-of-the-conventional-marker-compounds-for-quality-evaluation-of-radix-saposhnikoviae
#20
Jing-Ming Yang, Hua Jiang, Hong-Liang Dai, Zi-Wei Wang, Gui-Zhi Jia, Xiang-Cai Meng
INTRODUCTION: 4'-O-β-D-glucosyl-5-O-methylvisamminol (GML) is a conventional marker compound for quality control of Radix Saposhnikoviae. Despite that, neither pharmacodynamic or pharmacokinetic information is available with regard to GML. As such, the aim of thisstudy was to assess the conventional evaluation indices for the quality of Radix Saposhnikoviae. MATERIALS AND METHODS: Pyretic animal model, hot plate test, and ear edema model were established to evaluate and compare the antipyretic, analgesic, and anti-inflammatory effect of the chromone derivativescimifugin, prime-O-glucosylcimifugin (PGCN), and GML in Radix Saposhnikoviae...
January 2017: Pharmacognosy Magazine
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