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https://www.readbyqxmd.com/read/27598601/effects-of-melatonin-on-cytokine-release-and-healing-of-colonic-anastomoses-in-an-experimental-sepsis-model
#1
Ömer Faik Ersoy, Namık Özkan, Zeki Özsoy, Hüseyin Ayhan Kayaoğlu, Erdinç Yenidoğan, Alper Çelik, Aziz Fikret Özuğurlu, Ebru Arabacı Çakır, Neşe Lortlar
BACKGROUND: The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model. METHODS: A total of 60 Wistar albino rats were divided into 2 groups. Cecal ligation puncture (CLP) and colonic resection anastomosis were performed on both the control group and the melatonin treatment group. Both groups were divided into 3 subgroups consisting of 10 rats each. One subgroup from each group underwent re-laparotomy at the 16th hour, the next on the 3rd day, and the final subgroup on the 7th day...
July 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27489727/development-of-rheumatoid-arthritis-during-treatment-of-multiple-sclerosis-with-interferon-beta-1-a-coincidence-of-two-conditions-or-a-complication-of-treatment-a-case-report
#2
Seyed Mohammad Masood Hojjati, Behzad Heidari, Mansour Babaei
Coexistence of multiple sclerosis (MS) with other autoimmune diseases has been attributed to common background genetic or environmental factors. This study presents development of rheumatoid arthritis (RA) during treatment of MS. The MS was confirmed by the Mc Donald criteria and the diagnosis of RA was confirmed by the ACR/EULAR criteria. A 35 years old women with 9 years of MS who was receiving interferon beta 1-a (INF) for 7 years and who did not respond to conventional therapy of RA over 8 months developed clinical manifestations of RA...
September 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27415587/immunohistochemical-analysis-of-il-1-beta-in-the-discs-of-patients-with-temporomandibular-joint-dysfunction
#3
Luis Eduardo Almeida, Sean Pierce, Joseph Zacharias, William Cullinan, Lucia Noronha, Marcia Olandoski, Vinicius Tramontina, Carla Loreto, Rosalia Leonardi
PURPOSE: Interleukin-1 beta (IL-1β) is a cytokine that participates in the regulation of immune responses and inflammatory reactions. It is hypothesized that IL-1 levels may be elevated in patients suffering from temporomandibular joint dysfunction. The purpose of this study was to determine the association of IL-1β expression with TMD using an immunohistochemical approach to evaluate the joint disc. MATERIALS AND METHODS: A total of 39 human temporomandibular joint disc samples were collected, with 31 samples in the test group...
July 13, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27343364/use-of-a-non-covalent-cell-penetrating-peptide-strategy-to-enhance-the-nasal-delivery-of-interferon-beta-and-its-pegylated-form
#4
Yuko Iwase, Noriyasu Kamei, El-Sayed Khafagy, Mitsuko Miyamoto, Mariko Takeda-Morishita
The conjugation of therapeutic proteins to polyethylene glycol (PEG) is known as PEGylation. It improves their retention in the body and reduces the frequency of injections. Development of noninvasive delivery systems for biopharmaceuticals can improve the patients' quality of life. The present study aimed to evaluate the cell-penetrating peptides (CPPs), which act as bioenhancers, for the nasal delivery of protein drug interferon beta (IFN-β) and its PEGylated form (PEG-IFN-β). The ability of CPPs to enhance the nasal mucosal absorption of unmodified IFN-β was assessed in rats...
August 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27339320/improvement-of-immune-responses-to-influenza-vaccine-h5n1-by-sulfated-yeast-beta-glucan
#5
Mi Wang, Lifang Zhang, Ruile Yang, Chenzhong Fei, Xiaoyang Wang, Keyu Zhang, Chunmei Wang, Wenli Zheng, Feiqun Xue
In this study, the adjuvant activity of sulfated glucan from saccharomyces cerevisiae (SGSC) was investigated. sGSC had molecular weight of 12.9kDa and degrees of sulfation of 0.16.The effects of SGSC on the splenic lymphocyte cells of mice were measured in vitro. The results showed that SGSC could significantly promote lymphocyte proliferation singly or synergistically with Con A and LPS, and stimulate the cells to secrete IL-2 and INF-γ. The adjuvant activity of SGSC was researched in BALB/c mice inoculated with inactivated H5N1vaccine in vivo...
June 20, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27306062/assessment-of-il-17a-il-10-and-tgf-beta1-serum-titers-in-rrms-patients-treated-with-avonex-possible-biomarkers-for-treatment-response
#6
Rodica Bălaşa, Smaranda Maier, Septimiu Voidăzan, Adina Huţanu, Zoltán Bajkó, Anca Moţăţăianu, Brindusa Tilea, Cristina Tiu
: Individual response to interferon beta (IFN-β) 1a treatment is heterogeneous in multiple sclerosis (MS). Our objective was to find a connection between serum levels of interleukin (IL)-10, IL-17 and transforming growth factor beta (TGF-β)1 in MS patients treated with IFN-β in order to identify the nonresponders (NR). MATERIAL AND METHODS: We included in the study 32 healthy subjects and 32 MS patients: 10 naive, 10 early treated and 12 late treated with INF-β1a...
June 15, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27279989/brain-derived-neurotrophic-and-immunologic-factors-beneficial-effects-of-riboflavin-on-motor-disability-in-murine-model-of-multiple-sclerosis
#7
Mahshid Naghashpour, Reza Amani, Alireza Sarkaki, Ata Ghadiri, Alireza Samarbafzadeh, Sima Jafarirad, Amal Saki Malehi
OBJECTIVES: In the present study, C57BL/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis. MATERIALS AND METHODS: The animals were assigned into 7 groups: sham-operated 1 (SO1), healthy mice receiving PBS (phosphate buffer saline); sham-operated 2 (SO2), healthy mice receiving PBS and riboflavin; sham treatment 1 (ST1), EAE mice receiving water; sham treatment 2 (ST2), EAE mice receiving sodium acetate buffer; treatment 1 (T1), EAE mice receiving interferon beta-1a (INFβ-1a); treatment 2 (T2), EAE mice receiving riboflavin; treatment 3 (T3), EAE mice receiving INFβ-1a and riboflavin...
April 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27239677/sodium-selenite-protects-against-silver-nanoparticle-induced-testicular-toxicity-and-inflammation
#8
Sabah Ansar, Manal Abudawood, Sherifa Shaker Hamed, Mukhtar M Aleem
Metal nanomaterials hold great potential and play an important role in consumer products. However, the increasing use of nanomaterials has raised concern over inadvertent exposure and potential risks for human health and the environment. Henceforth, in vivo testing of nanoparticles and protection against its toxicity is required. Using rat as an animal model, effect of sodium selenite (Se), an essential trace element, on rat testes exposed to silver nanoparticles (AgNPs) was evaluated. Male rats were treated with AgNPs (5 mg/kg/b...
May 30, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27237769/long-term-efficacy-and-safety-of-intramuscular-interferon-beta-1a-randomized-postmarketing-trial-of-two-dosing-regimens-in-japanese-patients-with-relapsing-remitting-multiple-sclerosis
#9
Takahiko Saida, Jun-Ichi Kira, Yasuhiro Ueno, Naozumi Harada, Toshiyuki Hirakata
OBJECTIVES: To evaluate the efficacy and safety of 2 years of treatment with intramuscular interferon beta-1a (IM IFN beta-1a) in Japanese patients with relapsing-remitting multiple sclerosis, with an exploratory analysis of the impact of initial dose titration on tolerability. METHODS: Japanese patients with relapsing-remitting multiple sclerosis were randomized to receive IM IFN beta-1a at dosages of either 30mcg once weekly (full-dose group, n=50) or 15mcg once weekly for 2 weeks then 30mcg once weekly thereafter (titration group, n=50)...
May 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27226183/effect-of-melatonin-supplementation-on-plasma-lipid-hydroperoxides-homocysteine-concentration-and-chronic-fatigue-syndrome-in-multiple-sclerosis-patients-treated-with-interferons-beta-and-mitoxantrone
#10
M Adamczyk-Sowa, P Sowa, J Adamczyk, N Niedziela, H Misiolek, M Owczarek, K Zwirska-Korczala
UNLABELLED: Multiple sclerosis (MS) prevalence is higher in geographic regions with less sunlight exposure. Melatonin participates in the effects of sunlight in healthy individuals and could play a role in MS pathophysiology. Melatonin crosses the blood-brain barrier and exerts antioxidative, immunomodulatory, and anti-inflammatory effects. Chronic fatigue syndrome concerns 80 - 90% MS patients. The pathophysiology of chronic fatigue syndrome is unknown, however activation of immune, inflammatory, oxidative and nitrosative stress mechanisms and plasma lipid peroxide elevation was reported...
April 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27194829/th1-th2-and-treg-t17-cytokines-in-two-types-of-proliferative-glomerulonephritis
#11
M Stangou, C Bantis, M Skoularopoulou, L Korelidou, D Kouloukouriotou, M Scina, I T Labropoulou, N M Kouri, A Papagianni, G Efstratiadis
IgA nephropathy (IgAN) and focal segmental necrotizing glomerulonephritis (FSNGN) are characterized by proliferation of native glomerular cells and infiltration by inflammatory cells. Several cytokines act as mediators of kidney damage in both diseases. The aim of the present study was to investigate the role of Th1, Th2 and Treg/T17 cytokines in these types of proliferative glomerulonephritis. Simultaneous measurement of Th1 interleukin (IL-2, IL-12, tumor necrosis factor-alpha [TNF-α], interferon-gamma [INF-γ]), Th2 (IL-4, IL-5, IL-6, IL-10, IL-13), Treg/T17 transforming growth factor-beta 1 (TGF-β1, granulocyte-macrophage colony-stimulating factor [GM-CSF], IL-17) cytokines and C-C chemokines Monocyte chemoattractant protein-1 (MCP-1, macrophage inflammatory protein-1 [MIP-1] β) was performed in first-morning urine samples, at the day of renal biopsy, using a multiplex cytokine assay...
May 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/26986868/plasma-concentrations-of-transforming-growth-factor-beta-1-in-non-progressive-hiv-1-infection-correlates-with-markers-of-disease-progression
#12
Edward K Maina, C Z Abana, E A Bukusi, M Sedegah, M Lartey, W K Ampofo
The human immunodeficiency virus (HIV) infection shows variable rate of disease progression. The underlying biological and molecular mechanisms involved in determining progression of HIV infection are not fully understood. The aims of this study were to determine plasma concentrations of active TGF β 1, Th1 and Th2 cytokines in patients with non-progressive and those with progressive HIV-1 infection, as well as to determine if there is an association of these cytokines to disease progression. In a cross-sectional study of 61 HIV-1 infected individuals categorized according to disease progression as having non-progressive HIV-1 infection (n=14) and progressive infection (n=47), plasma levels of active TGF β 1, INF-γ, TNF-α, IL-10, IL-1β, IL-12p70 and IL-13 were compared with HIV uninfected healthy controls (n=12)...
May 2016: Cytokine
https://www.readbyqxmd.com/read/26935230/eeg-response-varies-with-lesion-location-in-patients-with-chronic-stroke
#13
Wanjoo Park, Gyu Hyun Kwon, Yun-Hee Kim, Jong-Hwan Lee, Laehyun Kim
BACKGROUND: Brain activation differs according to lesion location in functional magnetic resonance imaging (fMRI) studies, but lesion location-dependent electroencephalographic (EEG) alterations are unclear. Because of the increasing use of EEG-based brain-computer-interface rehabilitation, we examined lesion location-dependent EEG patterns in patients with stroke while they performed motor tasks. METHODS: Twelve patients with chronic stroke were divided into three subgroups according to their lesion locations: supratentorial lesions that included M1 (SM1+), supratentorial lesions that excluded M1 (SM1-), and infratentorial (INF) lesions...
2016: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/26730582/il-10-and-tgf%C3%AE-mediated-th9-responses-in-a-human-helminth-infection
#14
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Jeeva Jagannathan, Chandrakumar Dolla, Paul Kumaran, Thomas B Nutman, Subash Babu
BACKGROUND: Th9 cells are a subset of CD4+ T cells that express the protoypical cytokine, IL-9. Th9 cells are known to effect protective immunity in animal models of intestinal helminth infections. However, the role of Th9 cells in human intestinal helminth infections has never been examined. METHODOLOGY: To examine the role of Th9 cells in Strongyloidis stercoralis (Ss), a common intestinal helminth infection, we compared the frequency of Th9 expressing IL-9 either singly (mono-functional) or co-expressing IL-4 or IL-10 (dual-functional) in Ss-infected individuals (INF) to frequencies in uninfected (UN) individuals...
January 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26405999/study-of-amyloid-%C3%AE-peptide-functional-brain-networks-in-ad-mci-and-hc
#15
Jiehui Jiang, Huoqiang Duan, Zheming Huang, Zhihua Yu
One medical challenge in studying the amyloid-β (Aβ) peptide mechanism for Alzheimer's disease (AD) is exploring the law of beta toxic oligomers' diffusion in human brains in vivo. One beneficial means of solving this problem is brain network analysis based on graph theory. In this study, the characteristics of Aβ functional brain networks of Healthy Control (HC), Mild Cognitive Impairment (MCI), and AD groups were compared by applying graph theoretical analyses to Carbon 11-labeled Pittsburgh compound B positron emission tomography (11C PiB-PET) data...
2015: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/26313906/type-i-interferons-function-as-autocrine-and-paracrine-factors-to-induce-autotaxin-in-response-to-tlr-activation
#16
Jianwen Song, Ming Guan, Zhenwen Zhao, Junjie Zhang
Lysophosphatidic acid (LPA) is an important phospholipid mediator in inflammation and immunity. However, the mechanism of LPA regulation during inflammatory response is largely unknown. Autotaxin (ATX) is the key enzyme to produce extracellular LPA from lysophosphatidylcholine (LPC). In this study, we found that ATX was induced in monocytic THP-1 cells by TLR4 ligand lipopolysaccharide (LPS), TLR9 ligand CpG oligonucleotide, and TLR3 ligand poly(I:C), respectively. The ATX induction by TLR ligand was abolished by the neutralizing antibody against IFN-β or the knockdown of IFNAR1, indicating that type I IFN autocrine loop is responsible for the ATX induction upon TLR activation...
2015: PloS One
https://www.readbyqxmd.com/read/26202988/parasite-antigen-specific-regulation-of-th1-th2-and-th17-responses-in-strongyloides-stercoralis-infection
#17
Rajamanickam Anuradha, Saravanan Munisankar, Chandrakumar Dolla, Paul Kumaran, Thomas B Nutman, Subash Babu
Chronic helminth infections are known to be associated with modulation of Ag-specific CD4(+) T responses. However, the role of CD4(+) T cell responses in human infection with Strongyloides stercoralis is not well defined. To examine the role of CD4(+) T cells expressing Th1, Th2, and Th17 cytokines in strongyloidiasis, we compared the frequency (Fo) of these subsets in infected (INF) individuals with Fo in S. stercoralis-uninfected (UN) individuals. INF individuals exhibited a significant decrease in the spontaneous and Ag-specific Fo of both monofunctional and dual-functional Th1 cells compared with UN...
September 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26202481/negative-feedback-circuit-for-toll-like-receptor-8-activation-in-human-embryonic-kidney-293-using-outer-membrane-vesicle-delivered-bi-specific-sirna
#18
Anurag Adhikari, Birendra Prasad Gupta, Krishna Das Manandhar, Shravan Kumar Mishra, Hari Krishna Saiju, Rajendra Maan Shrestha, Nawneet Mishra, Shishir Sharma
BACKGROUND: TLR8 assists in antiviral approach by producing Type 1 INF via MyD88 dependent IRF7 pathway. However, over expression of INFα/β molecule poses threat by developing tolerance in chronic infection cases and enhancing inflammatory response. Here we report a bi-specific siRNA based complex which differentially activates and silences the TLR8 and MYD88 respectively in a negatively regulated fashion. RESULTS: Outer membrane vesicle from Escherichia coli used for siRNA delivery was observed more efficient when attached with invasive protein Ail along with OmpA (P<0...
2015: BMC Immunology
https://www.readbyqxmd.com/read/26125411/hepcidin-ferroportin-axis-controls-toll-like-receptor-4-dependent-macrophage-inflammatory-responses-in-human-atherosclerotic-plaques
#19
Anwer Habib, Rohini Polavarapu, Vinit Karmali, Liang Guo, Richard Van Dam, Qi Cheng, Hirokuni Akahori, Omar Saeed, Masataka Nakano, Kimberly Pachura, Charles C Hong, Eric Shin, Frank Kolodgie, Renu Virmani, Aloke V Finn
OBJECTIVES: Toll-like Receptor 4 (TLR4) is implicated in modulating inflammatory cytokines though its role in atherosclerosis remains uncertain. We have recently described a non-foam cell macrophage phenotype driven by ingestion of hemoglobin:haptoglobin complexes (HH), via the scavenger receptor CD163, characterized by reduced inflammatory cytokine production. In this study, we examined the role of iron metabolism in modulating TLR4 signaling in these cells. METHODS AND RESULTS: Areas in human atherosclerotic plaque with non-foam cell, CD163 positive macrophages demonstrated reduced expression of tumor necrosis factor alpha (TNF-α) and interferon-beta (INF-β) compared to foam cells...
August 2015: Atherosclerosis
https://www.readbyqxmd.com/read/26086440/cladribine-exposure-results-in-a-sustained-modulation-of-the-cytokine-response-in-human-peripheral-blood-mononuclear-cells
#20
Melanie Korsen, Sara Bragado Alonso, Lizzy Peix, Barbara M Bröker, Alexander Dressel
BACKGROUND AND OBJECTIVES: Cladribine is a cytotoxic drug which ameliorates the clinical course of relapsing-remitting multiple sclerosis. In addition to cytotoxicity, the mode of action may include immunomodulatory mechanisms. This in vitro study was designed to investigate cladribine's effects on cell function after the removal of cladribine to distinguish cytotoxic versus immunomodulatory effects. METHODS: Cells were incubated in the absence or presence of cladribine (1 × 10(-8) M to 1 × 10(-5) M) for 72 h...
2015: PloS One
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