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John H. Zhang

Qiang Li, Yujie Chen, Xuan Zhang, Shilun Zuo, Hongfei Ge, Yanyan Chen, Xin Liu, John H Zhang, Huaizhen Ruan, Hua Feng
Angiographic vasospasm, especially in the early phases (<72h) of subarachnoid hemorrhage (SAH), is one of the major complications after an aneurysm rupture and is often the cause of delayed neurological deterioration. Scutellarin (SCU), a flavonoid extracted from the traditional Chinese herb Erigeron breviscapus, has been widely accepted as an antioxidant, but the effect of SCU on vasospasm after SAH remains elusive. Endovascular perforation was conducted to induce SAH in Sprague-Dawley rats. Then, the underlying mechanism of the anti-vasospasm effect of SCU was investigated using a modified Garcia scale, India ink angiography, cross-sectional area analysis, immunohistochemistry staining and western blot...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Hajera Amatullah, Yuexin Shan, Brittany L Beauchamp, Patricia L Gali, Sahil Gupta, Tatiana Maron-Gutierrez, Edwin R Speck, Alison E Fox-Robichaud, Jennifer L Y Tsang, Shirley H J Mei, Tak W Mak, Patricia Rm Rocco, John W Semple, Haibo Zhang, Pingzhao Hu, John C Marshall, Duncan J Stewart, Mary-Ellen Harper, Patricia C Liaw, W Conrad Liles, Claudia C Dos Santos
RATIONALE & OBJECTIVES: Effective and rapid bacterial clearance is a fundamental determinant of outcome(s) in sepsis. DJ-1 is a well-established reactive oxygen species (ROS) scavenger. As cellular ROS status is pivotal to inflammation and bacterial killing, we determined the role of DJ-1 in bacterial sepsis. METHODS: We used cell and murine models with gain and loss of function experiments, plasma and cells from septic patients. MEASUREMENTS & RESULTS: Stimulation of bone marrow derived macrophages (BMM) with endotoxin resulted in increased DJ-1 mRNA and protein expression...
October 13, 2016: American Journal of Respiratory and Critical Care Medicine
Daniel A Thomas, Matthew M Coggon, Hanna Lignell, Katherine Ann Schilling, Xuan Zhang, Rebecca H Schwantes, Richard C Flagan, John H Seinfeld, Jesse Lee Beauchamp
The complexation of iron (III) with oxalic acid in aqueous solution yields a strongly absorbing chromophore that undergoes efficient photodissociation to give iron (II) and the carbon dioxide anion radical. Importantly, iron (III) oxalate complexes absorb near-UV radiation (λ > 350 nm), providing a potentially powerful source of oxidants in aqueous tropospheric chemistry. Although this photochemical system has been studied extensively, the mechanistic details associated with its role in the oxidation of dissolved organic matter within aqueous aerosol remain largely unknown...
October 12, 2016: Environmental Science & Technology
Christina Loley, Maris Alver, Themistocles L Assimes, Andrew Bjonnes, Anuj Goel, Stefan Gustafsson, Jussi Hernesniemi, Jemma C Hopewell, Stavroula Kanoni, Marcus E Kleber, King Wai Lau, Yingchang Lu, Leo-Pekka Lyytikäinen, Christopher P Nelson, Majid Nikpay, Liming Qu, Elias Salfati, Markus Scholz, Taru Tukiainen, Christina Willenborg, Hong-Hee Won, Lingyao Zeng, Weihua Zhang, Sonia S Anand, Frank Beutner, Erwin P Bottinger, Robert Clarke, George Dedoussis, Ron Do, Tõnu Esko, Markku Eskola, Martin Farrall, Dominique Gauguier, Vilmantas Giedraitis, Christopher B Granger, Alistair S Hall, Anders Hamsten, Stanley L Hazen, Jie Huang, Mika Kähönen, Theodosios Kyriakou, Reijo Laaksonen, Lars Lind, Cecilia Lindgren, Patrik K E Magnusson, Eirini Marouli, Evelin Mihailov, Andrew P Morris, Kjell Nikus, Nancy Pedersen, Loukianos Rallidis, Veikko Salomaa, Svati H Shah, Alexandre F R Stewart, John R Thompson, Pierre A Zalloua, John C Chambers, Rory Collins, Erik Ingelsson, Carlos Iribarren, Pekka J Karhunen, Jaspal S Kooner, Terho Lehtimäki, Ruth J F Loos, Winfried März, Ruth McPherson, Andres Metspalu, Muredach P Reilly, Samuli Ripatti, Dharambir K Sanghera, Joachim Thiery, Hugh Watkins, Panos Deloukas, Sekar Kathiresan, Nilesh J Samani, Heribert Schunkert, Jeanette Erdmann, Inke R König
In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD...
October 12, 2016: Scientific Reports
Jie Zhang, Alan R Light, Charles L Hoppel, Caitlin Campbell, Carol J Chandler, Dustin J Burnett, Elaine C Souza, Gretchen A Casazza, Ronald W Hughen, Nancy L Keim, John W Newman, Gary R Hunter, Jose R Fernandez, W Timothy Garvey, Mary-Ellen Harper, Oliver Fiehn, Sean H Adams
With insulin-resistance or type 2 diabetes mellitus, mismatches between mitochondrial fatty acid fuel delivery and oxidative phosphorylation/tricarboxylic acid cycle activity may contribute to inordinate accumulation of short- or medium-chain acylcarnitine fatty acid derivatives (markers of incomplete long-chain fatty acid oxidation [FAO]). We reasoned that incomplete FAO in muscle would be ameliorated concurrent with improved insulin sensitivity and fitness following a ∼14 wk training and weight loss intervention in obese, sedentary, insulin-resistant women...
October 12, 2016: Experimental Physiology
Hai-Yun Xiao, Scott H Watterson, Charles M Langevine, Anurag S Srivastava, Soo S Ko, Yanlei Zhang, Robert Joseph Cherney, Weiwei Guo, John L Gilmore, James E Sheppeck, Dauh-Rurng Wu, Peng Li, Duraisamy Ramasamy, Pirama Nayagam Arunachalam, Arvind Mathur, Tracy L Taylor, David J Shuster, Kim W McIntyre, Ding Ren Shen, Melissa Yarde, Mary Ellen Cvijic, Anthony M Marino, Praveen V Balimane, Zheng Yang, Dana M Banas, Georgia Cornelius, Celia J D Arienzo, Bethanne M Warrack, Lois D Lehman-McKeeman, Luisa M Salter-Cid, Jenny H Xie, Joel C Barrish, Percy H Carter, Alaric J Dyckman, T G Murali Dhar
Fingolimod (1) is the first approved oral therapy for the treatment of relapsing remitting multiple sclerosis. While the phosphorylated metabolite of fingolimod was found to be a non-selective S1P receptor agonist, agonism specifically of S1P1 is responsible for the peripheral blood lymphopenia believed to be key to its efficacy. Identification of modulators that maintain activity on S1P1 while sparing activity on other S1P receptors could offer equivalent efficacy with reduced liabilities. We disclose in this paper a ligand based drug design approach that led to the discovery of a series of potent tricyclic agonists of S1P1 with selectivity over S1P3 and were efficacious in a pharmacodynamic model of suppression of circulating lymphocytes...
October 11, 2016: Journal of Medicinal Chemistry
Wenli Zhang, Caibin Li, Bruce C Baguley, Fang Zhou, Weisai Zhou, John P Shaw, Zhen Wang, Zimei Wu, Jianping Liu
To obtain a multicellular MCF-7 spheroid model to mimic the three-dimensional (3D) of tumors, the microwell liquid overlay (A) and hanging-drop/agar (B) methods were first compared for their technical parameters. Then a method for embedding spheroids within collagen was optimized. For method A, centrifugation assisted cells form irregular aggregates but not spheroids. For method B, an extended sedimentation period of over 24 h for cell suspensions and increased viscosity of the culture medium using methylcellulose were necessary to harvest a dense and regular cell spheroid...
October 5, 2016: Analytical Biochemistry
Igor Ying Zhang, Patrick Rinke, John P Perdew, Matthias Scheffler
We present a new paradigm for the design of exchange-correlation functionals in density-functional theory. Electron pairs are correlated explicitly by means of the recently developed second order Bethe-Goldstone equation (BGE2) approach. Here we propose a screened BGE2 (sBGE2) variant that efficiently regulates the coupling of a given electron pair. sBGE2 correctly dissociates H_{2} and H_{2}^{+}, a problem that has been regarded as a great challenge in density-functional theory for a long time. The sBGE2 functional is then taken as a building block for an orbital-dependent functional, termed ZRPS, which is a natural extension of the PBE0 hybrid functional...
September 23, 2016: Physical Review Letters
Tianxi Yang, Bin Zhao, Ruyan Hou, Zhiyun Zhang, Amanda J Kinchla, John M Clark, Lili He
Understanding pesticide penetration is important for effectively applying pesticides and in reducing pesticide exposures from food. This study aims to evaluate multiclass systemic and nonsystemic pesticide penetration in 3 representative fresh produce (apples, grapes, and spinach leaves). Surface-enhanced Raman scattering mapping was applied for in situ and real-time tracking of pesticide penetration over time. The results show that 100 mg/L of systemic pesticides, thiabendazole and acetamiprid, penetrated more rapidly and deeply with maximum depth around 220 μm after 48-h exposure into the tested fresh produce than 100 mg/L of nonsystemic pesticides, ferbam and phosmet, with maximum depth about 80 μm...
October 6, 2016: Journal of Food Science
William J Pearce, Coleen Doan, Desirelys Carreon, Dahlim Kim, Lara M Durrant, Anatol Manaenko, Lauren McCoy, Andre Obenaus, John H Zhang, Jiping Tang
This study explores the hypothesis that intracerebral hemorrhage (ICH) promotes release of diffusible factors that can significantly influence the structure and function of cerebral arteries remote from the site of injury, through action on platelet-derived growth factor (PDGF) receptors. Four groups of adult male Sprague Dawley rats were studied (n=8 each): 1) Sham; 2) Sham + 60 mg/kg IP imatinib; 3) ICH (collagenase method); and 4) ICH + 60 mg/kg IP imatinib given 60 min after injury. At 24 hours post-injury, sham artery passive diameters (+3 mM EGTA) averaged 244±7 µm (@60 mmHg)...
October 5, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Cristovão M Sousa, Douglas E Biancur, Xiaoxu Wang, Christopher J Halbrook, Mara H Sherman, Li Zhang, Daniel Kremer, Rosa F Hwang, Agnes K Witkiewicz, Haoqiang Ying, John M Asara, Ronald M Evans, Lewis C Cantley, Costas A Lyssiotis, Alec C Kimmelman
No abstract text is available yet for this article.
October 5, 2016: Nature
Fan Liao, Gaofeng Li, Wen Yuan, Yujie Chen, Yuchun Zuo, Kauthar Rashid, John H Zhang, Hua Feng, Fei Liu
Hydrocephalus has been demonstrated to be an independent risk factor for poor outcomes in patients with subarachnoid hemorrhage (SAH). Blockage of cerebrospinal fluid (CSF) flow and drainage is widely considered to play a vital role in communicating hydrocephalus, possibly due to subarachnoid fibrosis. A previous study indicated that transforming growth factor-β1 (TGF-β1), a key fibrogenic factor, is significantly increased in the CSF following SAH, implying a pivotal role in the development of chronic hydrocephalus...
October 2016: Experimental and Therapeutic Medicine
Zhi Liu, Qiang Li, Gaoyu Cui, Gang Zhu, Weihua Tang, Hengli Zhao, John H Zhang, Yujie Chen, Hua Feng
Previously, it was widely accepted that the delayed ischemic injury and poor clinical outcome following subarachnoid hemorrhage (SAH) was caused by cerebral vasospasm. This classical theory was challenged by a clazosentan clinical trial, which failed to improve patient outcome, despite reversing angiographic vasospasm. One possible explanation for the results of this trial is the changes in microcirculation following SAH, particularly in pericytes, which are the primary cell type controlling microcirculation in the brain parenchyma...
October 2016: Experimental and Therapeutic Medicine
T Velasquez, G Mackey, J Lusk, U G Kyle, T Fontenot, P Marshall, L S Shekerdemian, J A Coss-Bu, A Nishigaki, T Yatabe, T Tamura, K Yamashita, M Yokoyama, J C Ruiz-Rodriguez, B Encina, R Belmonte, I Troncoso, P Tormos, M Riveiro, J Baena, A Sanchez, J Bañeras, J Cordón, N Duran, A Ruiz, J Caballero, X Nuvials, J Riera, J Serra, A M F Rutten, S N M van Ieperen, E P H M Der Kinderen, T Van Logten, L Kovacikova, P Skrak, M Zahorec, U G Kyle, A Akcan-Arikan, J C Silva, G Mackey, J Lusk, M Goldsworthy, L S Shekerdemian, J A Coss-Bu, D Wood, D Harrison, R Parslow, P Davis, J Pappachan, S Goodwin, P Ramnarayan, S Chernyshuk, H Yemets, V Zhovnir, S M Pulitano', S De Rosa, A Mancino, G Villa, F Tosi, P Franchi, G Conti, B Patel, H Khine, A Shah, D Sung, L Singer, S Haghbin, S Inaloo, Z Serati, M Idei, T Nomura, N Yamamoto, Y Sakai, T Yoshida, Y Matsuda, Y Yamaguchi, S Takaki, O Yamaguchi, T Goto, N Longani, S Medar, I R Abdel-Aal, A S El Adawy, H M E H Mohammed, A N Mohamed, S M Parry, L D Knight, L Denehy, N De Morton, C E Baldwin, D Sani, G Kayambu, V Z M da Silva, P Phongpagdi, Z A Puthucheary, C L Granger, J E Rydingsward, C M Horkan, K B Christopher, D McWilliams, C Jones, E Reeves, G Atkins, C Snelson, L M Aitken, J Rattray, J Kenardy, A M Hull, A Ullman, R Le Brocque, M Mitchell, C Davis, B Macfarlane, J C Azevedo, L L Rocha, F F M De Freitas, A M Cavalheiro, N M Lucinio, M S Lobato, G Ebeling, A Kraegpoeth, E Laerkner, I De Brito-Ashurst, C White, S Gregory, L G Forni, E Flowers, A Curtis, C A Wood, K Siu, K Venkatesan, J B H Muhammad, L Ng, E Seet, N Baptista, A Escoval, E Tomas, R Agrawal, R Mathew, A Varma, E Dima, E Charitidou, E Perivolioti, M Pratikaki, C Vrettou, A Giannopoulos, S Zakynthinos, C Routsi, E Atchade, S Houzé, S Jean-Baptiste, G Thabut, C Genève, S Tanaka, B Lortat-Jacob, P Augustin, M Desmard, P Montravers, F J González de Molina, S Barbadillo, R Alejandro, F Álvarez-Lerma, J Vallés, R M Catalán, E Palencia, A Jareño, R M Granada, M L Ignacio, N Cui, D Liu, H Wang, L Su, H Qiu, R Li, K Jaffal, A Rouzé, J Poissy, B Sendid, S Nseir, E Paramythiotou, M Rizos, F Frantzeskaki, A Antoniadou, S Vourli, L Zerva, A Armaganidis, J Riera, J Gottlieb, M Greer, O Wiesner, M Martínez, M Acuña, J Rello, T Welte, E Atchade, T Mignot, S Houzé, S Jean-Baptiste, G Thabut, B Lortat-Jacob, S Tanaka, P Augustin, M Desmard, P Montravers, S Soussi, E Dudoignon, A Ferry, M Chaussard, M Benyamina, A Alanio, S Touratier, M Chaouat, M Lafaurie, M Mimoun, A Mebazaa, M Legrand, M A Sheils, C Patel, L Mohankumar, N Akhtar, S K Pacheco Noriega, N Navarrete Aldana, J L Ávila León, J Durand Baquero, F Fernández Bernal, E Ahmadnia, J S Hadley, M Millar, D Hall, H Hewitt, H Yasuda, M Sanui, T Komuro, S Kawano, K Andoh, H Yamamoto, E Noda, J Hatakeyama, N Saitou, H Okamoto, A Kobayashi, T Takei, S Matsukubo, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Gimillo, O Diaz Barinas, M L Blasco Cortes, J Ferreres Franco, J M Segura Roca, A Carratalá, B Gonçalves, R Turon, A Mendes, F Miranda, P J Mata, D Cavalcanti, N Melo, P Lacerda, P Kurtz, C Righy, L E de la Cruz Rosario, S P Gómez Lesmes, J C García Romero, A N García Herrera, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J Barado Hualde, A Ansotegui Hernández, J M Guergué Irazabal, V Spatenkova, O Bradac, P Suchomel, T Urli, E Heusch Lazzeri, R Aspide, M Zanello, L Perez-Borrero, J M Garcia-Alvarez, M D Arias-Verdu, E Aguilar-Alonso, R Rivera-Fernandez, J Mora-Ordoñez, C De La Fuente-Martos, E Castillo-Lorente, F Guerrero-Lopez, S P Gómez Lesmes, L E De la Cruz Rosario, E D Díaz Pertuz, A Ansotegui Hernández, J C García Romero, M J Gómez Sánchez, A N García Herrera, J Roldán Ramírez, E Regidor Sanz, J Barado Hualde, J P Tirapu León, L Navarro-Guillamón, S Cordovilla-Guardia, A Iglesias-Santiago, F Guerrero-López, E Fernández-Mondéjar, A Vidal, M Perez, A Juez, N Arias, L Colino, J L Perez, H Pérez, P Calpe, M A Alcala, D Robaglia, C Perez, S K Lan, M M Cunha, T Moreira, F Santos, E Lafuente, M J Fernandes, J G Silva, L E de la Cruz Rosario, S P Gómez Lesmes, A N García Herrera, J C García Romero, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J G Armando Echeverría, A Ansotegui Hernández, J Barado Hualde, V Podlepich, E Sokolova, E Alexandrova, K Lapteva, P Kurtz, C Shuinotsuka, L Rabello, G Vianna, A Reis, C Cairus, J Salluh, F Bozza, J C Barrios Torres, N J Fernández Araujo, P García-Olivares, E Keough, M Dalorzo, L K Tang, I De Sousa, M Díaz, L J Marcos-Zambrano, J E Guerrero, S E Zamora Gomez, G D Hernandez Lopez, A I Vazquez Cuellar, O R Perez Nieto, J A Castanon Gonzalez, D Bhasin, S Rai, H Singh, O Gupta, M K Bhattal, S Sampley, K Sekhri, R Nandha, F A Aliaga, F Olivares, F Appiani, P Farias, F Alberto, A Hernández, S Pons, R Sonneville, L Bouadma, M Neuville, E Mariotte, A Radjou, J Lebut, S Chemam, G Voiriot, M P Dilly, B Mourvillier, R Dorent, P Nataf, M Wolff, J F Timsit, O Ediboglu, S Ataman, H Ozkarakas, C Kirakli, A Vakalos, V Avramidis, O Obukhova, I A Kurmukov, S Kashiya, E Golovnya, V N Baikova, T Ageeva, T Haritydi, E V Kulaga, J J Rios-Toro, L Perez-Borrero, E Aguilar-Alonso, M D Arias-Verdu, J M Garcia-Alvarez, C Lopez-Caler, C De La Fuente-Martos, S Rodriguez-Fernandez, M Gomez Sanchez-Orézzoli, F Martin-Gallardo, J Nikhilesh, V Joshi, E Villarreal, J Ruiz, M Gordon, A Quinza, J Gimenez, M Piñol, A Castellanos, P Ramirez, Y D Jeon, W Y Jeong, M H Kim, I Y Jeong, M Y Ahn, J Y Ahn, S H Han, J Y Choi, Y G Song, J M Kim, N S Ku, H Shah, F Kellner, F Rezai, N Mistry, P Yodice, V Ovnanian, K Fless, E Handler, R Martínez Alejos, J D Martí Romeu, D González Antón, A Quinart, A Torres Martí, M Llaurado-Serra, A Lobo-Civico, A Ventura-Rosado, A Piñol-Tena, M Pi-Guerrero, C Paños-Espinosa, M Peralvo-Bernat, J Marine-Vidal, R Gonzalez-Engroba, N Montesinos-Cerro, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, S Helyar, P Riozzi, A Noon, G Hallows, H Cotton, J Keep, P A Hopkins, A Taggu, S Renuka, S Sampath, P J T Rood, T Frenzel, R Verhage, M Bonn, P Pickkers, J G van der Hoeven, M van den Boogaard, F Corradi, L Melnyk, F Moggia, R Pienovi, G Adriano, C Brusasco, L Mariotti, M Lattuada, M J Bloomer, M Coombs, K Ranse, R Endacott, B Maertens, K Blot, S Blot, M P van Nieuw Amerongen, E S van der Heiden, J W R Twisk, A R J Girbes, J J Spijkstra, P Riozzi, S Helyar, H Cotton, G Hallows, A Noon, C Bell, K Peters, A Feehan, J Keep, P A Hopkins, K Churchill, K Hawkins, R Brook, N Paver, R Endacott, N Maistry, A van Wijk, N Rouw, T van Galen, S Evelein-Brugman, A Taggu, B Krishna, S Sampath, A Putzu, M Fang, M Boscolo Berto, A Belletti, T Cassina, L Cabrini, M Mistry, Y Alhamdi, I Welters, S T Abrams, C H Toh, H S Han, E M Gil, D S Lee, C M Park, S Winder-Rhodes, R Lotay, J Doyle, M W Ke, W C Huang, C H Chiang, W T Hung, C C Cheng, K C Lin, S C Lin, K R Chiou, S R Wann, C W Shu, P L Kang, G Y Mar, C P Liu, S Dubó, A Aquevedo, M Jibaja, D Berrutti, C Labra, R Lagos, M F García, V Ramirez, M Tobar, F Picoita, C Peláez, D Carpio, L Alegría, C Hidalgo, K Godoy, J Bakker, G Hernández, Y Sadamoto, K Katabami, T Wada, Y Ono, K Maekawa, M Hayakawa, A Sawamura, S Gando, H Marin-Mateos, J L Perez-Vela, R Garcia-Gigorro, M A Corres Peiretti, M J Lopez-Gude, S Chacon-Alves, E Renes-Carreño, J C Montejo-González, K L Parlevliet, H R W Touw, M Beerepoot, C Boer, P W G Elbers, P R Tuinman, S A Abdelmonem, T A Helmy, I El Sayed, S Ghazal, S H Akhlagh, M Masjedi, K Hozhabri, E Kamali, I Zýková, B Paldusová, P Sedlák, D Morman, A M Youn, Y Ohta, M Sakuma, D Bates, T Morimoto, P L Su, W Y Chang, W C Lin, C W Chen, F Facchin, F Zarantonello, G Panciera, A De Cassai, A Venrdramin, A Ballin, T Tonetti, P Persona, C Ori, L Del Sorbo, S Rossi, G Vergani, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, T Tonetti, M Guanziroli, A Colombo, I Tomic, A Colombo, F Crimella, E Carlesso, V Gasparovic, L Gattinoni, A Serpa Neto, M Schmidt, T Pham, A Combes, M Gama de Abreu, P Pelosi, M J Schultz, B H Katira, D Engelberts, R E Giesinger, C Ackerley, T Yoshida, D Zabini, G Otulakowski, M Post, W M Kuebler, P J McNamara, B P Kavanagh, R Pirracchio, M Resche Rigon, M Carone, S Chevret, D Annane, S Eladawy, M El-Hamamsy, N Bazan, M Elgendy, G De Pascale, M S Vallecoccia, S L Cutuli, V Di Gravio, M A Pennisi, G Conti, M Antonelli, D T Andreis, W Khaliq, M Singer, J Hartmann, S Harm, S Alcantara Carmona, P Matia Almudevar, A Naharro Abellán, J Veganzones Ramos, L Pérez Pérez, B Lobo Valbuena, N Martínez Sanz, I Fernández Simón, M Arrigo, E Feliot, N Deye, A Cariou, B Guidet, S Jaber, M Leone, M Resche-Rigon, A Vieillard Baron, M Legrand, E Gayat, A Mebazaa, M Balik, I Kolnikova, M Maly, P Waldauf, G Tavazzi, J Kristof, A Herpain, F Su, E Post, F Taccone, J L Vincent, J Creteur, C Lee, F Hatib, Z Jian, S Buddi, M Cannesson, S Fileković, M Turel, R Knafelj, V Gorjup, R Stanić, P Gradišek, O Cerović, T Mirković, M Noč, J Tirkkonen, H Hellevuo, K T Olkkola, S Hoppu, K C Lin, W T Hung, C C Chiang, W C Huang, W C Juan, S C Lin, C C Cheng, P H Lin, K Y Fong, D S Hou, P L Kang, S R Wann, Y S Chen, G Y Mar, C P Liu, M Paul, W Bougouin, G Geri, F Dumas, B Champigneulle, S Legriel, J Charpentier, J P Mira, C Sandroni, A Cariou, J Zimmerman, E Sullivan, M Noursadeghi, B Fox, D Sampson, L McHugh, T Yager, S Cermelli, T Seldon, S Bhide, R A Brandon, R B Brandon, J Zwaag, R Beunders, P Pickkers, M Kox, F Gul, M K Arslantas, D Genc, N Zibandah, L Topcu, T Akkoc, I Cinel, E Greco, M P Lauretta, D T Andreis, M Singer, I Palacios Garcia, M Cordero, A Diaz Martin, T Aldabó Pallás, J Garnacho Montero, J Revuelto Rey, L Roman Malo, A A Tanaka Montoya, A D C Amador Martinez, L Y Delgado Ayala, E Monares Zepeda, J Franco Granillo, J Aguirre Sanchez, G Camarena Alejo, A Rugerio Cabrera, A Pedraza Montenegro, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, E Soilemezi, E Koco, S Savvidou, C Nouris, D Matamis, R Di Mussi, S Spadaro, C A Volta, M Mariani, A Colaprico, C Antonio, F Bruno, S Grasso, A Rodriguez, I Martín-Loeches, E Díaz, J R Masclans, F Gordo, J Solé-Violán, M Bodí, F X Avilés-Jurado, S Trefler, M Magret, L F Reyes, J Marín-Corral, J C Yebenes, A Esteban, A Anzueto, S Aliberti, M I Restrepo, J Skytte Larsson, B Redfors, S E Ricksten, R Haines, J Powell-Tuck, H Leonard, M Ostermann, R E Berthelsen, T S Itenov, A Perner, J U Jensen, M Ibsen, A E K Jensen, M H Bestle, T Bucknall, J Dixon, F Boa, I MacPhee, B J Philips, J Doyle, F Saadat, T Samuels, S Huddart, B McCormick, R DeBrunnar, J Preece, M Swart, C Peden, S Richardson, L Forni, P Kalfon, K Baumstarck, P Estagnasie, M A Geantot, A Berric, G Simon, B Floccard, T Signouret, M Boucekine, M Fromentin, M Nyunga, A Sossou, M Venot, R Robert, A Follin, A Renault, M Garrouste, O Collange, Q Levrat, 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Zhang, K Kubota, M Egi, S Mizobuchi, S Hegazy, A El-Keraie, E El Sayed, M Abd El Hamid, N J Rodrigues, M Pereira, I Godinho, J Gameiro, M Neves, J Gouveia, Z Costa E Silva, J A Lopes, J Mckinlay, M Kostalas, G Kooner, G Dudas, A Horton, C Kerr, N Karanjia, B Creagh-Brown, L Forni, A Yamazaki, M Sanz Ganuza, J A Martinez Molina, F Hidalgo Martinez, M T Chiquito Freile, N Garcia Fernandez, P Medrano Travieso, A Bandert, R Frithiof, M Lipcsey, D Smekal, P Schlaepfer, J D Durovray, V Plouhinec, C Chiappa, R Bellomo, A G Schneider, S Mitchell, J Durrant, H Street, E Dunthorne, J Shears, C Hernandez Caballero, R Hutchison, S Schwarze, S Ghabina, E Thompson, J R Prowle, C J Kirwan, C A Gonzalez, J L Pinto, V Orozco, J A Patiño, P K Garcia, K M Contreras, P Rodriguez, J E Echeverri
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
Brandon J Dixon, Di Chen, Yang Zhang, Jerry Flores, Jay Malaguit, Derek Nowrangi, John H Zhang, Jiping Tang
Neonatal hypoxic-ischemic encephalopathy (HIE) is an injury that often leads to detrimental neurological deficits. Currently, there are no established therapies for HIE and it is critical to develop treatments that provide protection after HIE. The objective of this study was to investigate the ability of interferon beta (IFNβ) to provide neuroprotection and reduce apoptosis after HIE. Postnatal Day 10 rat pups were subjected to unilateral carotid artery ligation followed by 2.5 hr of exposure to hypoxia (8% O2)...
October 2016: ASN Neuro
Chen Chen, June Ho Shin, Joshua T Eggold, Man Ki Chung, Luhua H Zhang, Jeremy Lee, John B Sunwoo
Oral squamous cell carcinoma (OSCC) is a highly invasive and metastatic malignancy. The nerve growth factor receptor (NGFR) has been observed to be expressed on a subset of cells in OSCC, and NGFR+ cells have greater tumor-initiating capacity in vivo. Further, inhibition of NGFR reduces tumor growth, indicating a functional role of this receptor; however, the mechanisms by which NGFR confers enhanced tumor formation are not known. Here, we used an established murine model of OSCC and gene expression array analysis to identify ESM1 as a downstream target gene of NGFR, critical for tumor invasion and metastasis...
September 23, 2016: Oncotarget
Xinyu Zhang, Amy C Justice, Ying Hu, Zuoheng Wang, Hongyu Zhao, Guilin Wang, Eric O Johnson, Brinda Emu, Richard E Sutton, John H Krystal, Ke Xu
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral integration and latency. However, epigenetic changes in the HIV-1-infected host genome have not been well characterized. Here, we report the first large-scale epigenome-wide association study of DNA methylation for HIV-1 infection. We recruited HIV-infected (n = 261) and uninfected (n = 117) patients from the Veteran Aging Cohort Study (VACS) and all samples were profiled for 485,521 CpG sites in DNA extracted from the blood...
August 12, 2016: Epigenetics: Official Journal of the DNA Methylation Society
Budbazar Enkhjargal, Devin W McBride, Anatol Manaenko, Cesar Reis, Yasushi Sakai, Jiping Tang, John H Zhang
In this study, we investigated the role of vitamin D3 (VitD3) on endogenous osteopontin (OPN), a neuroprotective glycoprotein, after subarachnoid hemorrhage (SAH). The endovascular perforation SAH model in Sprague-Dawley rats was used to study the effect of intranasal VitD3 (30 ng/kg) before (Pre-SAH + VitD3) and after (Post-SAH + VitD3) subarachnoid hemorrhage. Vitamin D3 (30, 60, 120 ng/kg/day) increased more than one fold endogenous OPN expression in astrocytes and endothelial cells of rat brain...
September 26, 2016: Journal of Cerebral Blood Flow and Metabolism
Luhua H Zhang, June Ho Shin, Mikel D Haggadone, John B Sunwoo
A tissue-resident population of natural killer cells (NK cells) in the liver has recently been described to have the unique capacity to confer immunological memory in the form of hapten-specific contact hypersensitivity independent of T and B cells. Factors regulating the development and maintenance of these liver-resident NK cells are poorly understood. The aryl hydrocarbon receptor (AhR) is a transcription factor modulated by exogenous and endogenous ligands that is important in the homeostasis of immune cells at barrier sites, such as the skin and gut...
September 26, 2016: Journal of Experimental Medicine
Valentina Iotchkova, Jie Huang, John A Morris, Deepti Jain, Caterina Barbieri, Klaudia Walter, Josine L Min, Lu Chen, William Astle, Massimilian Cocca, Patrick Deelen, Heather Elding, Aliki-Eleni Farmaki, Christopher S Franklin, Mattias Franberg, Tom R Gaunt, Albert Hofman, Tao Jiang, Marcus E Kleber, Genevieve Lachance, Jian'an Luan, Giovanni Malerba, Angela Matchan, Daniel Mead, Yasin Memari, Ioanna Ntalla, Kalliope Panoutsopoulou, Raha Pazoki, John R B Perry, Fernando Rivadeneira, Maria Sabater-Lleal, Bengt Sennblad, So-Youn Shin, Lorraine Southam, Michela Traglia, Freerk van Dijk, Elisabeth M van Leeuwen, Gianluigi Zaza, Weihua Zhang, Najaf Amin, Adam Butterworth, John C Chambers, George Dedoussis, Abbas Dehghan, Oscar H Franco, Lude Franke, Mattia Frontini, Giovanni Gambaro, Paolo Gasparini, Anders Hamsten, Aaron Issacs, Jaspal S Kooner, Charles Kooperberg, Claudia Langenberg, Winfried Marz, Robert A Scott, Morris A Swertz, Daniela Toniolo, Andre G Uitterlinden, Cornelia M van Duijn, Hugh Watkins, Eleftheria Zeggini, Mathew T Maurano, Nicholas J Timpson, Alexander P Reiner, Paul L Auer, Nicole Soranzo
Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK10K and 1000 Genomes Project into 35,981 study participants of European ancestry, followed by association analysis with 20 quantitative cardiometabolic and hematological traits. We describe 17 new associations, including 6 rare (minor allele frequency (MAF) < 1%) or low-frequency (1% < MAF < 5%) variants with platelet count (PLT), red blood cell indices (MCH and MCV) and HDL cholesterol...
September 26, 2016: Nature Genetics
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