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John Zhang

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https://www.readbyqxmd.com/read/29149608/a-distinct-gene-module-for-dysfunction-uncoupled-from-activation-in-tumor-infiltrating-t-cells
#1
Meromit Singer, Chao Wang, Le Cong, Nemanja D Marjanovic, Monika S Kowalczyk, Huiyuan Zhang, Jackson Nyman, Kaori Sakuishi, Sema Kurtulus, David Gennert, Junrong Xia, John Y H Kwon, James Nevin, Rebecca H Herbst, Itai Yanai, Orit Rozenblatt-Rosen, Vijay K Kuchroo, Aviv Regev, Ana C Anderson
No abstract text is available yet for this article.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29146970/origin-of-the-unusually-strong-and-selective-binding-of-vanadium-by-polyamidoximes-in-seawater
#2
Alexander S Ivanov, Christina J Leggett, Bernard F Parker, Zhicheng Zhang, John Arnold, Sheng Dai, Carter W Abney, Vyacheslav S Bryantsev, Linfeng Rao
Amidoxime-functionalized polymeric adsorbents are the current state-of-the-art materials for collecting uranium (U) from seawater. However, marine tests show that vanadium (V) is preferentially extracted over U and many other cations. Herein, we report a complementary and comprehensive investigation integrating ab initio simulations with thermochemical titrations and XAFS spectroscopy to understand the unusually strong and selective binding of V by polyamidoximes. While the open-chain amidoxime functionalities do not bind V, the cyclic imide-dioxime group of the adsorbent forms a peculiar non-oxido V(5+) complex, exhibiting the highest stability constant value ever observed for the V(5+) species...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29145002/different-transport-behaviors-of-bacillus-subtilis-cells-and-spores-in-saturated-porous-media-implications-for-contamination-risks-associated-with-bacterial-sporulation-in-aquifer
#3
Qi Li, Jiakuan Yang, Wei Fan, Dandan Zhou, Xiaoyu Wang, Leilei Zhang, Mingxin Huo, John C Crittenden
In this study, we compared the transport characteristics of Bacillus subtilis cells and their spores in saturated porous media. Both the bacteria cells and spores were readily transported under lower ionic strengths (IS) (1mM), featuring high mass recovery rates (>75%). The bacteria cells recovery rate declined to 58.05% when the IS increased to 100mM; but the spores recovery rate remained at 74.54%. Spores appear to be more mobile than bacterial cells over wide range of IS. Surface properties and breakthrough curves analysis of the two bio-particles (cells and spores) indicated that attachment, straining and blocking mechanisms contribute differently to deposition processes...
November 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29144515/detection-of-sepsis-in-patient-blood-samples-using-cd64-expression-in-a-microfluidic-cell-separation-device
#4
Ye Zhang, Wenjie Li, Yun Zhou, Amanda Johnson, Amanda Venable, Ahmed Hassan, John Griswold, Dimitri Pappas
A microfluidic affinity separation device was developed for the detection of sepsis in critical care patients. An affinity capture method was developed to capture cells based on changes in CD64 expression in a single, simple microfluidic chip for sepsis detection. Both sepsis patient samples and a laboratory CD64+ expression model were used to validate the microfluidic assay. Flow cytometry analysis showed that the chip cell capture had a linear relationship with CD64 expression in laboratory models. The Sepsis Chip detected an increase in upregulated neutrophil-like cells when the upregulated cell population is as low as 10% of total cells spiked into commercially available aseptic blood samples...
November 16, 2017: Analyst
https://www.readbyqxmd.com/read/29141226/a-pan-cancer-analysis-of-the-expression-and-clinical-relevance-of-small-nucleolar-rnas-in-human-cancer
#5
Jing Gong, Yajuan Li, Chun-Jie Liu, Yu Xiang, Chunlai Li, Youqiong Ye, Zhao Zhang, David H Hawke, Peter K Park, Lixia Diao, John A Putkey, Liuqing Yang, An-Yuan Guo, Chunru Lin, Leng Han
Increasing evidence has demonstrated that small nucleolar RNAs (snoRNAs) play important roles in tumorigenesis. We systematically investigated the expression landscape and clinical relevance of snoRNAs in >10,000 samples across 31 cancer types from The Cancer Genome Atlas. We observed overall elevated expression of snoRNAs and their ribonucleoproteins in multiple cancer types. We showed complex regulation of snoRNA expression by their host genes, copy number variation, and DNA methylation. Unsupervised clustering revealed that the snoRNA expression subtype is highly concordant with other molecular/clinical subtypes...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29141136/systemic-mrna-delivery-to-the-lungs-by-functional-polyester-based-carriers
#6
Yunfeng Yan, Hu Xiong, Xinyi Zhang, Qiang Cheng, Daniel John Siegwart
Messenger RNA (mRNA) has recently come into focus as an emerging therapeutic class with great potential for protein replacement therapy, cancer immunotherapy, regenerative medicine, vaccines, and gene editing. However, the lack of effective and safe delivery methods impedes the broad application of mRNA-based therapeutics. Here, we report a robust approach to develop efficient polymeric delivery carriers for mRNA. Lead polyesters were identified by in vitro screening of a 480-member combinatorially modified poly(trimethylolpropane allyl ether-co-suberoyl chloride) library for the delivery of luciferase encoding mRNA (Luc mRNA) to IGROV1 cells...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29140488/us-national-cancer-institute-china-collaborative-studies-on-chinese-medicine-and-cancer
#7
Libin Jia, Hongsheng Lin, Joost Oppenheim, O M Zack Howard, Jie Li, Huiting Fan, Zhizheng Zhao, William Farrar, Ying Zhang, Nancy Colburn, Matthew R Young, Weidong Li, David Newman, Barry R O'Keefe, John Beutler, Jikai Liu, Xiaojiang Hao, Xiaosheng Yang, Tengfei Ji, Jeffrey D White
Since 2007, the US National Cancer Institute (NCI) Office of Cancer Complementary and Alternative Medicine (OCCAM), together with the Cancer Institute of the China Academy of Chinese Medical Sciences (CICACMS), institutes at China Academy of Sciences and Chinese Academy of Medical Sciences, have engaged in collaborations on Chinese medicine (CM) and cancer research. Through these collaborations, CM drugs and compounds have been studied at NCI labs. This paper summarizes the discoveries and progress on these research projects, exploring the aspects of cancer prevention, botanical drug mechanisms of action and component analysis/quality control (QC), and anticancer activity screening...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29138419/ivig-activates-fc%C3%AE-riib-ship1-pip3-pathway-to-stabilize-mast-cells-and-suppress-inflammation-after-ich-in-mice
#8
Gokce Yilmaz Akyol, Anatol Manaenko, Onat Akyol, Ihsan Solaroglu, Wing Mann Ho, Yan Ding, Jerry Flores, John H Zhang, Jiping Tang
Following intracerebral hemorrhage (ICH), the activation of mast cell contributes to brain inflammation and brain injury. The mast cell activation is negatively regulated by an inhibitory IgG-receptor. It's signals are mediated by SHIP (Src homology 2-containing inositol 5' phosphatase), in particular SHIP1, which activation leads to hydrolyzation of PIP3 (Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3, leading to the inhibition of calcium mobilization and to the attenuation of mast cell activation...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138314/imaging-and-quantifying-ganglion-cells-and-other-transparent-neurons-in-the-living-human-retina
#9
Zhuolin Liu, Kazuhiro Kurokawa, Furu Zhang, John J Lee, Donald T Miller
Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human retina, GCs remain elusive due to their high optical translucency...
November 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29135884/prognostic-factors-and-treatment-of-spinal-astrocytomas-a-multi-institutional-cohort-analysis
#10
Yingjie Zou, James Sun, Yangying Zhou, Harrison Xiao Bai, Xiangyan Huang, Ranjith Babu, Alessandro Landi, Kap Sum Foong, Zishu Zhang, John Woo, Yongguang Tao, Xuejun Li, Xiangqi Tang, Bo Xiao, Paul Zhang, Li Yang
STUDY DESIGN: Retrospective cohort analysis of patients with spinal astrocytoma from multi-institutional data and the literature. OBJECTIVE: To determine the prognostic factors, treatment, and survival of patients. SUMMARY OF BACKGROUND DATA: Our current understanding of the epidemiology, prognosis and optimal treatment of spinal astrocytoma is limited. The literature is confined to case reports or small institutional case series. METHOD: Patient demographics, tumor characteristics, treatments, and outcomes were extracted...
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29135224/radiation-responsive-esculin-derived-molecular-gels-as-signal-enhancers-for-optical-imaging
#11
Julian R Silverman, Qize Zhang, Nabendu B Pramanik, Malick Samateh, Travis M Shaffer, Sai Sateesh Sagiri, Jan Grimm, George John
Recent interest in detecting visible photons that emanate from interactions of ionizing radiation with matter have spurred the development of multifunctional materials that amplify this optical signal from radiotracers. Tailored stimuli-responsive systems may be paired with diagnostic radionuclides to improving surgical guidance and aid in detecting therapeutic radionuclides otherwise difficult to image with conventional nuclear medicine approaches. Since light emanating from these interactions is typically low in intensity and blue-weighted (i...
November 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29132371/survey-of-vector-borne-agents-in-feral-cats-and-first-report-of-babesia-gibsoni-in-cats-on-st-kitts-west-indies
#12
Patrick John Kelly, Liza Köster, Jing Li, Jilei Zhang, Ke Huang, Gillian Carmichael Branford, Silvia Marchi, Michel Vandenplas, Chengming Wang
BACKGROUND: As there is little data on vector-borne diseases of cats in the Caribbean region and even around the world, we tested feral cats from St Kitts by PCR to detect infections with Babesia, Ehrlichia and spotted fever group Rickettsia (SFGR) and surveyed them for antibodies to Rickettsia rickettsii and Ehrlichia canis. RESULTS: Whole blood was collected from apparently healthy feral cats during spay/ neuter campaigns on St Kitts in 2011 (N = 68) and 2014 (N = 52)...
November 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29132146/identification-of-unique-neoantigen-qualities-in-long-term-survivors-of-pancreatic-cancer
#13
Vinod P Balachandran, Marta Łuksza, Julia N Zhao, Vladimir Makarov, John Alec Moral, Romain Remark, Brian Herbst, Gokce Askan, Umesh Bhanot, Yasin Senbabaoglu, Daniel K Wells, Charles Ian Ormsby Cary, Olivera Grbovic-Huezo, Marc Attiyeh, Benjamin Medina, Jennifer Zhang, Jennifer Loo, Joseph Saglimbeni, Mohsen Abu-Akeel, Roberta Zappasodi, Nadeem Riaz, Martin Smoragiewicz, Z Larkin Kelley, Olca Basturk, Mithat Gönen, Arnold J Levine, Peter J Allen, Douglas T Fearon, Miriam Merad, Sacha Gnjatic, Christine A Iacobuzio-Donahue, Jedd D Wolchok, Ronald P DeMatteo, Timothy A Chan, Benjamin D Greenbaum, Taha Merghoub, Steven D Leach
Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens remain unknown. Here we use genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer. Using whole-exome sequencing and in silico neoantigen prediction, we found that tumours with both the highest neoantigen number and the most abundant CD8(+) T-cell infiltrates, but neither alone, stratified patients with the longest survival...
November 8, 2017: Nature
https://www.readbyqxmd.com/read/29131898/association-of-maternal-obesity-with-longitudinal-ultrasonographic-measures-of-fetal-growth-findings-from-the-nichd-fetal-growth-studies-singletons
#14
Cuilin Zhang, Mary L Hediger, Paul S Albert, Jagteshwar Grewal, Anthony Sciscione, William A Grobman, Deborah A Wing, Roger B Newman, Ronald Wapner, Mary E D'Alton, Daniel Skupski, Michael P Nageotte, Angela C Ranzini, John Owen, Edward K Chien, Sabrina Craigo, Sungduk Kim, Katherine L Grantz, Germaine M Buck Louis
Importance: Despite the increasing prevalence of pregravid obesity, systematic evaluation of the association of maternal obesity with fetal growth trajectories is lacking. Objective: To characterize differences in fetal growth trajectories between obese and nonobese pregnant women, and to identify the timing of any observed differences. Design, Setting, and Participants: The Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singletons study enrolled cohorts of pregnant women at 12 US health care institutions...
November 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29129376/lysophosphatidylcholine-regulates-sexual-stage-differentiation-in-the-human-malaria-parasite-plasmodium-falciparum
#15
Nicolas M B Brancucci, Joseph P Gerdt, ChengQi Wang, Mariana De Niz, Nisha Philip, Swamy R Adapa, Min Zhang, Eva Hitz, Igor Niederwieser, Sylwia D Boltryk, Marie-Claude Laffitte, Martha A Clark, Christof Grüring, Deepali Ravel, Alexandra Blancke Soares, Allison Demas, Selina Bopp, Belén Rubio-Ruiz, Ana Conejo-Garcia, Dyann F Wirth, Edyta Gendaszewska-Darmach, Manoj T Duraisingh, John H Adams, Till S Voss, Andrew P Waters, Rays H Y Jiang, Jon Clardy, Matthias Marti
Transmission represents a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, are infective to the mosquito vector. Gametocyte production rates vary depending on environmental conditions, but external stimuli remain obscure. Here, we show that the host-derived lipid lysophosphatidylcholine (LysoPC) controls P. falciparum cell fate by repressing parasite sexual differentiation...
November 2, 2017: Cell
https://www.readbyqxmd.com/read/29128334/a-map-of-human-mitochondrial-protein-interactions-linked-to-neurodegeneration-reveals-new-mechanisms-of-redox-homeostasis-and-nf-%C3%AE%C2%BAb-signaling
#16
Ramy H Malty, Hiroyuki Aoki, Ashwani Kumar, Sadhna Phanse, Shahreen Amin, Qingzhou Zhang, Zoran Minic, Florian Goebels, Gabriel Musso, Zhuoran Wu, Hosam Abou-Tok, Michael Meyer, Viktor Deineko, Sandy Kassir, Vishaldeep Sidhu, Matthew Jessulat, Nichollas E Scott, Xuejian Xiong, James Vlasblom, Bhanu Prasad, Leonard J Foster, Tiziana Alberio, Barbara Garavaglia, Haiyuan Yu, Gary D Bader, Ken Nakamura, John Parkinson, Mohan Babu
Mitochondrial protein (MP) dysfunction has been linked to neurodegenerative disorders (NDs); however, the discovery of the molecular mechanisms underlying NDs has been impeded by the limited characterization of interactions governing MP function. Here, using mass spectrometry (MS)-based analysis of 210 affinity-purified mitochondrial (mt) fractions isolated from 27 epitope-tagged human ND-linked MPs in HEK293 cells, we report a high-confidence MP network including 1,964 interactions among 772 proteins (>90% previously unreported)...
November 7, 2017: Cell Systems
https://www.readbyqxmd.com/read/29122858/genome-sequences-of-chancellor-mitti-and-wintermute-three-subcluster-k4-phages-isolated-using-mycobacterium-smegmatis-mc-2-155
#17
Nicholas P Edgington, Stephanie M Voshell, Vassie C Ware, Francis F Akoto, Alexa A Alhout, Gurvina J Atwal, John B Balyozian, Zachary A Cadieux, Brianna M Chop, Steven G Cresawn, Netta Cudkevich, Dylan Z Faltine-Gonzalez, Rebecca A Garlena, Blair J Gilmer, Lee H Graham, Matthew S Grapel, Maaz M Haleem, Deborah Jacobs-Sera, Margaret A Kenna, Maryam A Khan, Taylor N Klein, Jamie B Korenberg, Brooke P Lichak, Catherine M Mageeney, Lauren N McKinley, Kourtney R Mendello, Cameron M Myers, Alexander T Nguyen, Bryan A Pasqualucci, Welkin H Pope, Lauren M Pyfer, Wascar A Ramirez, Julia R Reisner, Daniel A Russell, Paulene A Sapao, Virginia C Saux, Inderjeet Singh, Ty H Stoner, Rachel H Swope, Matthew J Thoonkuzhy, Madeleine L Walters, Lauren A Vargas, Croldy A Veliz, Kevin D Zhang, Caitlin M Zuilkoski, Graham F Hatfull
Mycobacteriophages Chancellor, Mitti, and Wintermute infect Mycobacterium smegmatis mc(2)155 and are closely related to phages Cheetobro and Fionnbharth in subcluster K4. Genome sizes range from 57,697 bp to 58,046 bp. Phages are predicted to be temperate and to infect the pathogen Mycobacterium tuberculosis.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29122671/temporal-cytokine-and-lymphoid-responses-to-an-inhaled-tlr7-antedrug-agonist-in-the-cynomolgus-monkey-demonstrates-potential-safety-and-tolerability-of-this-approach
#18
John Bell, Mike Dymond, Mark Biffen, Stephen Delaney, David Keeling, Hui Zhang, Ian Robinson
AZD8848 is a TLR7 agonist antedrug developed for administration by inhalation dosing for the treatment of allergic diseases, such as asthma. Allergic asthma is associated with increased levels of Th2 cytokines which are suppressed for extended periods by TLR7 agonists in a number of preclinical models of allergic airway inflammation. However, TLRs form a central part of innate immunity and their activation often results in proinflammatory responses. Whilst AZD8848's antedrug mechanism is designed to restrict its pharmacological action beyond the lung, the effect of chronic, supramaximal dosing to the target tissue has yet to be defined...
November 6, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29120810/lasiodiplodia-theobromae-pat-griff-maubl-induced-disease-development-and-pericarp-browning-of-harvested-longan-fruit-in-association-with-membrane-lipids-metabolism
#19
Shen Zhang, Yuzhao Lin, Hetong Lin, Yixiong Lin, Yihui Chen, Hui Wang, John Shi, Yifen Lin
Effects of Lasiodiplodia theobromae inoculation on disease development, pericarp browning and membrane lipids metabolism of harvested "Fuyan" longan fruit were studied. Compared with control fruit, L. theobromae-inoculated longans showed higher fruit disease index, pericarp browning index and cell membrane permeability, as well as higher activities of phospholipase D, lipase and lipoxygenase. Additionally, there were lower contents of membrane phospholipids but higher content of phosphatidic acid, and lower level of unsaturated fatty acids but higher level of saturated ones with lower ratio of unsaturated fatty acid to saturated fatty acid and lower index of unsaturated fatty acids in pericarp of L...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29120233/development-of-a-high-performance-enterprise-level-multimode-lc-ms-ms-autosampler-for-drug-discovery
#20
Brendon Kapinos, JianHua Liu, Mary Piotrowski, Julie Keefer, Brian Holder, John Janiszewski, Hui Zhang, Matt Troutman
No abstract text is available yet for this article.
November 2017: Bioanalysis
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