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https://www.readbyqxmd.com/read/29036538/stlr4-md-2-complex-inhibits-colorectal-cancer-migration-and-invasiveness-in-vitro-and-in-vivo-by-lncrna-h19-down-regulation
#1
Weijun Liang, Yan Zou, Fengxian Qin, Jifei Chen, Junyi Xu, Shifeng Huang, Jingfan Chen, Shengming Dai
Long non-coding RNAs (lncRNAs) have multiple functions in gene regulation and during cellular processes. However, the functional roles of lncRNAs in colorectal cancer (CRC) have not yet been well understood. In our previous study, we demonstrated that sTLR4/MD-2 complex can inhibit CRC in vitro and in vivo by targeting LPS. Therefore, the aim of the present study is to investigate the expression of lncRNA H19 in CRC and to evaluate its effect on the inhibition of sTLR4/MD-2 complex. The expression of H19 is measured in 63 CRC tumor tissues and adjacent normal tissues by quantitative real-time PCR (qRT-PCR)...
September 28, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29033764/non-meckel-small-intestine-diverticulitis
#2
Shamim Ejaz, Raghu Vikram, John R Stroehlein
Non-Meckel small intestine diverticulitis can have many manifestations and its management is not well-defined. We report 4 unselect cases of small intestine diverticulitis; all patients were seen by the same physician at the Emergency Center at The University of Texas MD Anderson Cancer Center between 1999 and 2014. The median age at diagnosis of these patients was 82 years (range, 76-87 years). All 4 patients presented with acute onset of abdominal pain, and computed tomography scans showed characteristics of small intestine diverticulitis unrelated to cancer...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29032071/comparing-intestinal-versus-diffuse-gastric-cancer-using-a-peff-oriented-proteomic-pipeline
#3
Helisa Helena Wippel, Marlon Dias Mariano Santos, Milan Avila Clasen, Louise Ulrich Kurt, Fabio Cesar Sousa Nogueira, Carlos Eduardo Carvalho, Thaís Messias McCormick, Guilherme Pinto Bravo Neto, Lysangela Ronalte Alves, Maria da Gloria da Costa Carvalho, Paulo Costa Carvalho, Juliana de Saldanha da Gama Fischer
Gastric cancer is the fifth most common malignant neoplasia and the third leading cause of cancer death worldwide. Mac-Cormick et al. recently showed the importance of considering the anatomical region of the tumor in proteomic gastric cancer studies; more differences were found between distinct anatomical regions than when comparing healthy versus diseased tissue. Thus, failing to consider the anatomical region could lead to differential proteins that are not disease specific. With this as motivation, we compared the proteomic profiles of intestinal and diffuse adenocarcinoma from the same anatomical region, the corpus...
October 11, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29031817/bcrp-abcg2-and-high-alert-medications-biochemical-pharmacokinetic-pharmacogenetic-and-clinical-implications
#4
REVIEW
Daiki Hira, Tomohiro Terada
The human breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette efflux transporter that uses ATP hydrolysis to expel xenobiotics from cells, including anti-cancer medications. It is expressed in the gastrointestinal tract, liver, kidney, and brain endothelium. Thus, ABCG2 functions as a tissue barrier to drug transport that strongly influences the pharmacokinetics of substrate medications. Genetic polymorphisms of ABCG2 are closely related to inter-individual variations in therapeutic performance...
October 12, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29031499/micrornas-15a-and-16-1-activate-signaling-pathways-that-mediate-chemotaxis-of-immune-regulatory-b-cells-to-colorectal-tumors
#5
Ronghua Liu, Zhou Lu, Jie Gu, Jiajing Liu, Enyu Huang, Xiaoming Liu, Luman Wang, Jiao Yang, Yuting Deng, Jiawen Qian, Feifei Luo, Zhiming Wang, Hushan Zhang, Xuechao Jiang, Dan Zhang, Jing Qian, Guangwei Liu, Hongguang Zhu, Youcun Qian, Zhanju Liu, Yiwei Chu
BACKGROUND & AIMS: B cells infiltrate tumors but little is known about how they affect tumor growth and progression. microRNA15A (MIR15A or miRNA15A) and microRNA16-1 (MIR16-1 or miRNA16-1) regulate cell proliferation, apoptosis and drug resistance. We investigated their involvement in B cell-mediated immune suppression by colorectal tumors. METHODS: Mice with disruptions of the gene cluster that encodes MIR15A and MIR16-1 (KO mice), and control (C57BL/B6) mice were given azoxymethane with dextran sodium sulfate (AD) to induce formation of colorectal tumors...
October 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29030256/ficus-virens-proanthocyanidins-induced-apoptosis-in-breast-cancer-cells-concomitantly-ameliorated-5-fluorouracil-induced-intestinal-mucositis-in-rats
#6
Xiao-Xin Chen, Kar Ho Lam, Qing-Xi Chen, George Pak-Heng Leung, Sydney Chi Wai Tang, Stephen Cho-Wing Sze, Jian-Bo Xiao, Feng Feng, Ying Wang, Kalin Yan-Bo Zhang, Zhang-Jin Zhang
5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for breast cancer. However, its use often leads to drug resistance and mucositis. This study aimed to investigate whether proanthocyanidins from Ficus virens possessed anti-breast cancer and anti-mucositis activities. The results showed that the cytotoxic effects of the proanthocyanidins against MDA-MB-231 and MCF-7 breast cancer cells were in the order of stem barks proanthocyanidins (SPAs) > leaves proanthocyanidins > fruits proanthocyanidins...
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29029529/the-roles-of-maspin-expression-in-gastric-cancer-a-meta-and-bioinformatics-analysis
#7
Hua-Chuan Zheng, Bao-Cheng Gong
Maspin is a mammary serine protease inhibitor that is encoded by human SERPINB5 gene, and inhibits invasion and metastasis of cancer cells as a tumor suppressor. We performed a systematic meta- and bioinformatics analysis through multiple online databases up to Feb 10, 2017. We found down-regulated maspin expression in gastric cancer, compared with normal mucosa and dysplasia (p < 0.05). Maspin expression was negatively correlated with depth of invasion, TNM staging and dedifferentiation of gastric cancer (p < 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027650/correction-to-role-of-intestinal-microbiome-in-american-ginseng-mediated-colon-cancer-prevention-in-high-fat-diet-fed-aom-dss-mice
#8
C-Z Wang, W-H Huang, C-F Zhang, J-Y Wan, Y Wang, C Yu, S Williams, T-C He, W Du, M W Musch, E B Chang, C-S Yuan
This article was originally published with the wrong title.
October 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29027223/inflammatory-cell-death-in-intestinal-pathologies
#9
REVIEW
Deepika Sharma, Thirumala-Devi Kanneganti
The intestinal tract is a site of intense immune cell activity that is poised to mount an effective response against a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens. The role of cell death in gut pathologies is particularly important as the intestinal epithelium undergoes self-renewal every 4-7 days through a continuous process of cell death and cell division. Cell death is also required for removal of infected, damaged, and cancerous cells. Certain forms of cell death trigger inflammation through release of damage-associated molecular patterns...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29026312/robot-assisted-versus-conventional-laparoscopic-operation-in-anus-preserving-rectal-cancer-a-meta-analysis
#10
Yongzhen Cui, Cheng Li, Zhongfa Xu, Yingming Wang, Yamei Sun, Huirong Xu, Zengjun Li, Yanlai Sun
OBJECTIVE: The aim of this meta-analysis is to provide recommendations for clinical practice and prevention of postoperative complications, such as circumferential resection margin (CRM) involvement, and compare the amount of intraoperative bleeding, safety, operative time, recovery, outcomes, and clinical significance of robot-assisted and conventional laparoscopic procedures in anus-preserving rectal cancer. METHODS: A literature search (PubMed) was performed to identify biomedical research papers and abstracts of studies comparing robot-assisted and conventional laparoscopic procedures...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#11
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/29021485/spontaneous-regression-of-epithelioid-angiosarcoma-in-a-young-woman
#12
Suya Hori, Motoko Tachihara, Daisuke Tamura, Kazuyuki Kobayashi, Kyosuke Nakata, Hiroshi Kamiryo, Yasuhiro Sakai, Tomoo Itoh, Takanori Hirose, Yoshihiro Nishimura
A 20-year-old Japanese woman with a history of pulmonary atresia was referred to our hospital after the detection of an abnormal mass in the right lung and mediastinal lymphadenopathy. A cytological specimen obtained by transbronchial brushing indicated that the pathological diagnosis was non-small cell lung cancer. During the follow-up period, the tumor spontaneously regressed. At four months after the diagnosis, she experienced sudden bleeding from the small intestine. The histological characteristics of the small intestine tumor were compatible with the cytological characteristics of the lung tumor...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29021363/novel-and-unexpected-functions-of-sglts
#13
REVIEW
Ernest M Wright, Chiara Ghezzi, Donald D F Loo
It has been 30 years since the intestinal sodium glucose cotransporter SGLT1 was cloned, and, in the intervening years, there have been many advances that have influenced physiology and medicine. Among the first was that SGLT1 is the founding member of the human gene family SLC5, containing 11 diverse transporters and a glucose sensor. Equally surprising was that SGLTs are members of a structural family of cotransporters and exchangers in different gene families. This led to the conclusion that these proteins operate by a mechanism where transport involves the opening and closing of external and internal gates...
November 2017: Physiology
https://www.readbyqxmd.com/read/29020986/colorectal-cancer-infiltrating-t-lymphocytes-display-a-distinct-chemokine-receptor-expression-profile
#14
Ann-Britt Löfroos, Mohammad Kadivar, Sabina Resic Lindehammer, Jan Marsal
BACKGROUND: T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response. In both situations, the recruitment mechanisms of T lymphocytes into the tissues are essential for the immunological functions deciding the outcome. The recruitment of T lymphocytes is largely dependent on their expression of various chemokine receptors...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29019575/colon-cancer-surgery-in-patients-operated-on-an-emergency-basis
#15
Rodrigo Felippe Ramos, Lucas Carvalho Santos Dos-Reis, Beatriz Esteves Borgeth Teixeira, Igor Maroso Andrade, Jaqueline Suelen Sulzbach, Ricardo Ary Leal
OBJECTIVE: to study the epidemiological profile of patients with colorectal cancer operated on an emergency basis at the Bonsucesso Federal Hospital. METHODS: this is a retrospective study of patients operated between January 1999 and December 2012. We analyzed the following variables: age, gender, clinical data, TMN staging, tumor location, survival and types of surgery. RESULTS: we evaluated 130 patients in the study period. The most frequent clinical picture was intestinal obstruction, in 78% of cases...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29018997/gastrointestinal-perforation-related-to-lenvatinib-an-anti-angiogenic-inhibitor-that-targets-multiple-receptor-tyrosine-kinases-in-a-patient-with-metastatic-thyroid-cancer
#16
Emi Date, Kunio Okamoto, Souichi Fumita, Hiroyasu Kaneda
Lenvatinib, a novel potent multikinase inhibitor, was approved for the treatment of radioiodine-refractory differentiated thyroid cancer based on results from phase III trial (SELECT study). Thyroid cancer is a diverse disease that includes anaplastic thyroid cancer (ATC), which the most aggressive form of the disease, although it accounts for <2% of all thyroid cancers. Current treatments for ATC have limited efficacy. We report the case of a woman with recurrent well-differentiated papillary carcinoma of the thyroid that had transformed into ATC who developed a perforation of the small intestine secondary to a marked effect of lenvatinib...
October 11, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29018778/cancer-preventive-properties-of-an-anthocyanin-enriched-sweet-potato-in-the-apc-min-mouse-model
#17
Khalid Asadi, Lynnette R Ferguson, Martin Philpott, Nishi Karunasinghe
BACKGROUND: Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root. METHODS: We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APC (MIN/+) (APC(MIN)) mouse, a genetic model of colorectal cancer. APC(MIN) and C57BL/6J wild-type mice (n=160) were divided into four feeding groups consuming diets containing 10% SL222 sweet potato flesh, 10% SL222 sweet potato skin, or 0...
September 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29018272/bile-acid-microbiota-crosstalk-in-gastrointestinal-inflammation-and-carcinogenesis
#18
REVIEW
Wei Jia, Guoxiang Xie, Weiping Jia
Emerging evidence points to a strong association between the gut microbiota and the risk, development and progression of gastrointestinal cancers such as colorectal cancer (CRC) and hepatocellular carcinoma (HCC). Bile acids, produced in the liver, are metabolized by enzymes derived from intestinal bacteria and are critically important for maintaining a healthy gut microbiota, balanced lipid and carbohydrate metabolism, insulin sensitivity and innate immunity. Given the complexity of bile acid signalling and the direct biochemical interactions between the gut microbiota and the host, a systems biology perspective is required to understand the liver-bile acid-microbiota axis and its role in gastrointestinal carcinogenesis to reverse the microbiota-mediated alterations in bile acid metabolism that occur in disease states...
October 11, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29017737/laparoscopic-adenomectomy-10-years-of-experience
#19
J Carpio Villanueva, A Rosales Bordes, J Ponce de León Roca, M Montlleó González, J Caparrós Sariol, H Villavicencio Mavrich
INTRODUCTION: Lower urinary tract symptoms secondary to increased prostate volume are associated with ageing and are becoming more prevalent due to increased life expectancy. We present our experience with transperitoneal laparoscopic adenomectomy for the management of bladder outlet obstruction caused by benign prostatic enlargement. MATERIALS AND METHODS: We performed a retrospective review of patients who underwent laparoscopic adenomectomy between 2005 and 2015...
October 7, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29017601/mass-like-dieulafoy-s-lesion-associated-with-advanced-gastric-cancer-at-the-antrum-of-stomach-a-case-report-and-literature-review
#20
Hsi-Lan Huang, Chi Yan Leung, Chien-Jui Cheng
BACKGROUND: Dieulafoy's lesion, also known as a caliber-persistent artery, is a shallow, small, and rare lesion that occurs along the lesser curvature of proximal stomach. It is rare for a Dieulafoy's lesion to present as a mass-like lesion that coexists with gastric cancer. To our best knowledge, we report the first case and histopathological pictures of a mass-like Dieulafoy's lesion coexisting with advanced gastric cancer in the antrum of the stomach. CASE PRESENTATION: A 57-year-old female presented with a 6-month history of intermittent epigastric dull pain and dyspepsia...
October 10, 2017: Diagnostic Pathology
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