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Angiotensin II and endothelin

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https://www.readbyqxmd.com/read/27884701/cardiac-inositol-1-4-5-trisphosphate-receptors
#1
REVIEW
M Iveth Garcia, Darren Boehning
Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP3Rs have been associated with regulation of cardiomyocyte function in response to a variety of neurohormonal agonists, including those implicated in cardiac disease...
November 22, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27837397/from-arb-to-arni-in-cardiovascular-control
#2
REVIEW
Estrellita Uijl, Lodi C W Roksnoer, Ewout J Hoorn, A H Jan Danser
Coexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality. These high-risk, multi-morbid patient populations benefit less from currently available anti-hypertensive treatment. Simultaneous angiotensin II type 1 receptor blockade and neprilysin inhibition ('ARNI') with valsartan/sacubitril (LCZ696) might potentiate the beneficial effects of renin-angiotensin-aldosterone inhibition by reinforcing its endogenous counterbalance, the natriuretic peptide system...
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27836671/glycine-prevents-pressure-overload-induced-cardiac-hypertrophy-mediated-by-glycine-receptor
#3
Yan Lu, Xudong Zhu, Jinjie Li, Ru Fang, Zhuoyun Wang, Jing Zhang, Kexue Li, Xiaoyu Li, Hui Bai, Qing Yang, Jingjing Ben, Hanwen Zhang, Qi Chen
As a major amino acid, glycine has multiple functions in metabolism, growth, immunity, cytoprotection, and survival. The aim of this study was to determine the effects of glycine on pathologic cardiac hypertrophy and the mechanism underlying it. Pre-treatment with glycine significantly attenuated murine cardiac hypertrophy induced by transverse aortic constriction or by administration of angiotensin II (Ang II). This action was associated with a suppressive extracellular signal-regulated kinase 1/2 phosphorylation in myocardium...
November 9, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27825364/mid-regional-pro-adrenomedullin-mr-proadm-a-marker-of-positive-fluid-balance-in-critically-ill-patients-results-of-the-envol-study
#4
Bernard Vigué, Pierre-Etienne Leblanc, Frédérique Moati, Eric Pussard, Hussam Foufa, Aurore Rodrigues, Samy Figueiredo, Anatole Harrois, Jean-Xavier Mazoit, Homa Rafi, Jacques Duranteau
BACKGROUND: The optimal control of blood volume without fluid overload is a main challenge in the daily care of intensive care unit (ICU) patients. Accordingly this study focused on the identification of biomarkers to help characterize fluid overload status. METHODS: Sixty-seven patients were studied from ICU admission to day 7 (D7). Blood and urine samples were taken daily and sodium and water balance strictly calculated resulting in a total cumulative assessment of ∆Na(+) and ∆H2O...
November 9, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27798352/mitogen-activated-protein-kinase-p38-target-regenerating-islet-derived-3%C3%AE-expression-is-upregulated-in-cardiac-inflammatory-response-in-the-rat-heart
#5
Hanna Säkkinen, Jani Aro, Leena Kaikkonen, Pauli Ohukainen, Juha Näpänkangas, Heikki Tokola, Heikki Ruskoaho, Jaana Rysä
Regenerating islet-derived 3γ (Reg3γ) is a multifunctional protein, associated with various tissue injuries and inflammatory states. Since chronic inflammation is characteristics also for heart failure, the aim of this study was to characterize Reg3γ expression in cardiac inflammatory conditions. Reg3γ expression was studied in experimental rat models of myocardial infarction (MI) and pressure overload in vivo. For cell culture studies neonatal rat cardiac myocytes (NRCMs) were used. In addition, adenovirus-mediated gene transfer of upstream mitogen-activated protein kinase (MAPK) kinase 3b and p38α MAPK in vivo and in vitro was performed...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27777977/ip3-receptors-regulate-vascular-smooth-muscle-contractility-and-hypertension
#6
Qingsong Lin, Guiling Zhao, Xi Fang, Xiaohong Peng, Huayuan Tang, Hong Wang, Ran Jing, Jie Liu, W Jonathan Lederer, Ju Chen, Kunfu Ouyang
Inositol 1, 4, 5-trisphosphate receptor-mediated (IP3R-mediated) calcium (Ca(2+)) release has been proposed to play an important role in regulating vascular smooth muscle cell (VSMC) contraction for decades. However, whether and how IP3R regulates blood pressure in vivo remains unclear. To address these questions, we have generated a smooth muscle-specific IP3R triple-knockout (smTKO) mouse model using a tamoxifen-inducible system. In this study, the role of IP3R-mediated Ca(2+) release in adult VSMCs on aortic vascular contractility and blood pressure was assessed following tamoxifen induction...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27748925/hydrogen-sulfide-suppresses-angiotensin-ii-stimulated-endothelin-1-generation-and-subsequent-cytotoxicity-induced-endoplasmic-reticulum-stress-in-endothelial-cells-via-nf-%C3%AE%C2%BAb
#7
Heng-Jing Hu, Zhi-Sheng Jiang, Sheng-Hua Zhou, Qi-Ming Liu
The effects of hydrogen sulfide (H2S) and the nuclear factor κB (NF-κB) signaling pathway in angiotensin II (AngII)-induced endothelin-1 (ET-1) expression and subsequent cytotoxicity remain unclear. The present study aimed to investigate the hypothesis that H2S protects human umbilical vein endothelial cells (HUVECs) against AngII‑stimulated ET‑1 generation and subsequent cytotoxicity‑induced endoplasmic reticulum stress via the NF‑κB signaling pathway. The results of the present study demonstrated that AngII significantly upregulated the expression levels of ET‑1, glucose‑regulated protein 78, CCAAT‑enhancer‑binding protein homologous protein, phosphorylated (p)‑p65 and inducible nitric oxide synthase; stimulated nitric oxide production; suppressed the expression and activity of cystathionine-γ-lyase (CSE), a H2S synthetase; and decreased cell viability...
October 12, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27748819/src-tyrosine-kinase-mediates-endothelin-1-induced-early-growth-response-protein-1-expression-via-map-kinase-dependent-pathways-in-vascular-smooth-muscle-cells
#8
Estelle R Simo-Cheyou, George Vardatsikos, Ashok K Srivastava
We have previously demonstrated that the non-receptor protein tyrosine kinase (NR-PTK) c-Src is an upstream regulator of endothelin-1 (ET-1) and angiotensin II-induced activation of protein kinase B (PKB) signaling in vascular smooth muscle cells (VSMCs). We have also demonstrated that ET-1 potently induces the expression of the early growth response protein-1 (Egr-1), a zinc finger transcription factor that is overexpressed in models of vascular diseases, such as atherosclerosis. However, the involvement of c-Src in ET-1‑induced Egr-1 expression has not yet been investigated and its role in mitogen-activated protein kinase (MAPK) signaling remains controversial...
October 6, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27722168/role-of-histone-demethylases-in-cardiomyocytes-induced-to-hypertrophy
#9
Wendy Rosales, Juan Carulla, Jeison García, Diana Vargas, Fernando Lizcano
Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells. However, the role of the jumonji family of demethylases in the development of cardiac hypertrophy remains elusive. In this study, the presence of different histone demethylases in cardiac cells was evaluated after hypertrophy was induced with neurohormones. A cell line from rat cardiomyocytes was used as a biological model. The phenotypic profiles of the cells, as well as the expression of histone demethylases, were studied through immunofluorescence, transient transfection, western blot, and qRT-PCR analysis after inducing hypertrophy by angiotensin II and endothelin-1...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27692363/exogenous-melatonin-reduced-blood-pressure-in-late-term-ovine-fetus-via-mt1-mt2-receptor-pathways
#10
Jianying Tao, Juanxiu Lv, Weisheng Li, Pengjie Zhang, Caiping Mao, Zhice Xu
Melatonin is involved in the regulation of blood pressure through the receptor dependent or independent route. However, the effect of melatonin on fetal blood pressure is unknown. This study investigated the effect of melatonin on blood pressure of the late-term ovine fetus in utero. Melatonin and/or antagonists were intravenously administered into the fetuses. Mean arterial pressure and heart rate were recorded. Fetal blood samples were analyzed for biochemical parameters and hormones, including cortisol, angiotensin I, angiotensin II, aldosterone, atrial natriuretic peptide, corticotrophin-releasing hormone, adrenocorticotropic hormone, and endothelin...
September 2016: Reproductive Biology
https://www.readbyqxmd.com/read/27640901/immediate-and-catastrophic-antibody-mediated-rejection-in-a-lung-transplant-recipient-with-anti-angiotensin-ii-receptor-type-1-and-anti-endothelin-1-receptor-type-a-antibodies
#11
E Cozzi, F Calabrese, M Schiavon, P Feltracco, M Seveso, C Carollo, M Loy, M Cardillo, F Rea
Preexisting donor-specific anti-HLA antibodies (DSAs) have been associated with reduced survival of lung allografts. However, antibodies with specificities other than HLA may have a detrimental role on the lung transplant outcome. A young man with cystic fibrosis underwent lung transplantation with organs from a suitable deceased donor. At the time of transplantation, there were no anti-HLA DSAs. During surgery, the patient developed a severe and intractable pulmonary hypertension associated with right ventriular dysfunction, which required arteriovenous extracorporeal membrane oxygenation...
September 19, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27575704/facilitation-by-the-renin-angiotensin-system-of-cyclosporine-evoked-hypertension-in-rats-role-of-arterial-baroreflexes-and-vasoreactivity
#12
Suzanne A Nasser, Ramzi Sabra, Ahmed I Elmallah, Mahmoud M Mohy El-Din, Mohamed M Khedr, Mahmoud M El-Mas
AIMS: Cyclosporine (CSA) elevates blood pressure (BP) and alters arterial baroreflex sensitivity (BRS) and vasoreactivity. In this study we determined whether the renin-angiotensin system (RAS) interplays with other vasopressor pathways in mediating the CSA actions. MATERIALS AND METHODS: Whole animal and isolated vascular preparations were employed to determine the effects of pharmacologic interruption of angiotensin II (Ang II), endothelin (ET), or thromboxane (TXA2) signaling on the adverse cardiovascular effects of CSA...
October 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27530514/cardioprotective-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-agonist-rosiglitazone-in-a-unique-murine-model-of-diabetic-cardiopathy
#13
Suresh R Giri, Bibhuti Bhoi, Mukul R Jain, Madhumanjiri M Gatne
AIMS: Rosiglitazone (RSZ), a PPARγ agonist was potent efficacious insulin sensitizing blockbuster drug for treatment of Type 2 diabetes mellitus (T2DM) but the benefit of PPARγ activation in congestive heart failure (CHF) was controversial. The present work was planned to study the role of RSZ in diabetic cardiopathy. MAIN METHODS: Zucker fa/fa rats, the genetic model of T2DM were subjected to constriction of suprarenal abdominal aorta so that they represent a combined model of diabetes and cardiopathy...
October 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/27514554/-intervention-of-systolic-pressure-and-left-ventricular-hypertrophy-in-rats-under-cold-stress
#14
C F Sun, S G Wang, Y G Peng, Y Shi, Y P Du, G X Shi, T Wen, Y K Wang, H Su
OBJECTIVE: To investigate the effects of different drugs on systolic blood pressure (SBP) and left ventricular hypertrophy (LVH) in spontaneously hypertensive rats under cold stress. METHODS: A total of 40 male spontaneously hypertensive rats aged 10 weeks (160~200 g) were given adaptive feeding for 7 days at a temperature of 20±1°C and then randomly divided into control group, cold stress group, metoprolol group, amlodipine group, and benazepril group, with 8 rats in each group...
June 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27495766/non-hla-antibodies-may-accelerate-immune-responses-after-intestinal-and-multivisceral-transplantation
#15
Undine A Gerlach, Nils Lachmann, Giuseppina Ranucci, Birgit Sawitzki, Constanze Schoenemann, Johann Pratschke, Duska Dragun, Andreas Pascher
BACKGROUND: Non-HLA-allo- and autoantibodies are involved in allograft rejection in kidney and heart transplantation. Their role in intestinal transplantation has not yet been described. We examined the development of anti-Angiotensin II type I receptor antibodies (anti-AT1R) and anti-Endothelin-Type A receptor antibodies (anti-ETAR) associated with the clinical course and histopathological findings of ITX-recipients. METHODS: 37 patients underwent intestinal or multivisceral transplantation...
August 5, 2016: Transplantation
https://www.readbyqxmd.com/read/27488275/angiotensin-ii-type-1-receptor-agtr1-gene-polymorphisms-are-associated-with-vascular-manifestations-in-patients-with-systemic-sclerosis-ssc
#16
Tatiana S Rodríguez-Reyna, Carlos Núñez-Alvarez, Alfredo Cruz-Lagunas, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Luis Jiménez-Alvarez, Gustavo Ramírez-Martínez, Julio Granados, Gilberto Vargas-Alarcón, Joaquín Zúñiga
INTRODUCTION: Systemic sclerosis (SSc) shows variable clinical expression in different ethnic groups; vascular abnormalities are a prominent feature of this disease and its clinical expression may be influenced by genetic factors. PATIENTS AND METHODS: Herein, we describe 15 polymorphisms of the renin-angiotensin-aldosterone pathway in 170 Mexican admixed SSc patients (defined as patients with Mexican ancestry for at least 3 generations) and 199 healthy controls...
July 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27444511/endothelin-1-drives-epithelial-mesenchymal-transition-in-hypertensive-nephroangiosclerosis
#17
Teresa M Seccia, Brasilina Caroccia, Francesca Gioco, Maria Piazza, Valentina Buccella, Diego Guidolin, Eugenia Guerzoni, Barbara Montini, Lucia Petrelli, Elisa Pagnin, Verdiana Ravarotto, Anna S Belloni, Lorenzo A Calò, Gian Paolo Rossi
BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin-1 (ET-1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney. We therefore tested the hypothesis that tubulointerstitial fibrosis involves EMT driven by ET-1. METHODS AND RESULTS: Transgenic TG[mRen2]27 (TGRen2) rats developing fulminant angiotensin II-dependent hypertension with prominent cardiovascular and renal damage were submitted to drug treatments targeted to ET-1 and/or angiotensin II receptor or left untreated (controls)...
July 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27443965/gene-silencing-of-endothelial-von-willebrand-factor-attenuates-angiotensin-ii-induced-endothelin-1-expression-in-porcine-aortic-endothelial-cells
#18
Anar Dushpanova, Silvia Agostini, Enrica Ciofini, Manuela Cabiati, Valentina Casieri, Marco Matteucci, Silvia Del Ry, Aldo Clerico, Sergio Berti, Vincenzo Lionetti
Expression of endothelin (ET)-1 is increased in endothelial cells exposed to angiotensin II (Ang II), leading to endothelial dysfunction and cardiovascular disorders. Since von Willebrand Factor (vWF) blockade improves endothelial function in coronary patients, we hypothesized that targeting endothelial vWF with short interference RNA (siRNA) prevents Ang II-induced ET-1 upregulation. Nearly 65 ± 2% silencing of vWF in porcine aortic endothelial cells (PAOECs) was achieved with vWF-specific siRNA without affecting cell viability and growth...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27441535/estrogen-related-mechanisms-of-hypertension-in-menopausal-women
#19
M Buleishvili, N Lobjanidze, G Ormotsadze, M Enukidze, M Machavariani, T Sanikidze
The aim of our investigation was to establish the role of estrogens in the pathogenesis of hypertension during menopause. Menopausal women (40-55 years) with hypertension who had been admitted to "The N. Kipshidze Central University Clinic" (Tbilisi, Georgia) during 2011-2015 and without hypertension were investigated. Essential hypertension was defined as elevated blood pressure while in a sitting position, exceeding 160±10/90±10 mm Hg 60/95 mm Hg, for three consecutive measurements over a period of at least 4 weeks...
June 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27415782/co-inhibition-of-angiotensin-ii-receptor-and-endothelin-1-attenuates-renal-injury-in-unilateral-ureteral-obstructed-mice
#20
Yoon-Kyung Chang, Hyunsu Choi, Jin Young Jeong, Ki-Ryang Na, Kang Wook Lee, Dae Eun Choi
BACKGROUND/AIMS: Both endothelin-1 (ET-1) and the renin-angiotensin system (RAS) may play important roles in renal fibrosis in the obstructed kidney. However, there have been few clear demonstrations of a relationship between their activation and additive or synergistic roles in renal fibrosis. We investigated the protective roles and relationship between renal RAS and ET-1 in unilateral ureteral obstruction (UUO) mice. METHODS: 8-week-old male C57BL/6 mice were divided into seven groups: sham, bosentan+sham, valsartan+sham, vehicle+UUO, bosentan+UUO, valsartan+UUO, and valsartan+bosentan+UUO...
2016: Kidney & Blood Pressure Research
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