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https://www.readbyqxmd.com/read/29110871/prevalence-of-rifampicin-resistant-mycobacterium-tuberculosis-among-human-immunodeficiency-virus-seropositive-patients-and-their-treatment-outcomes
#1
C K Vidyaraj, A Chitra, S Smita, M Muthuraj, S Govindarajan, B Usharani, S Anbazhagi
Multidrug resistant (MDR) and extensively drug resistant tuberculosis (TB) are a threat to the TB control programs in developing countries, and the situation is worsened by the human immunodeficiency virus (HIV) pandemic. This study was performed to correlate treatment outcome with the resistance patterns in HIV-seropositive patients coinfected with pulmonary TB. Sputum specimens were collected from 1643 HIV-seropositive patients and subjected to microscopy and liquid culture for TB. The smear- and culture-positive Mycobacterium tuberculosis isolates were subjected to Genotype MTBDRplus assay version 2...
December 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/29098997/adverse-drug-reactions-and-treatment-outcome-analysis-of-dots-plus-therapy-of-mdr-tb-patients-at-district-tuberculosis-centre-a-four-year-retrospective-study
#2
Arif I Dela, Nitish Kumar D Tank, Anil P Singh, Kiran G Piparva
BACKGROUND: Treatment of multidrug-resistant tuberculosis (MDR-TB) requires the use of expensive and toxic second-line anti-tubercular drugs which are given for a longer duration. Adverse drug reactions (ADRs) of second-line antitubercular drugs affect compliance and thereby treatment outcome. We set out to analyze ADRs and treatment outcome of MDR-TB patients receiving directly observed treatments plus therapy. MATERIALS AND METHODS: A retrospective study of registered MDR-TB cases at district tuberculosis center during 2010-2014 was performed...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29036618/unsuccessful-treatment-in-pulmonary-tuberculosis-factors-and-a-consequent-predictive-model
#3
Ana Costa-Veiga, Teodoro Briz, Carla Nunes
Background: Cure is particularly valuable in pulmonary cases (PTB), as unsuccessful treatment fuels incidence and resistance to antibiotics. This study aims to identify individual factors of PTB unsuccessful treatment in Portugal and to develop a consequent predictive model. Methods: Using the Portuguese TB surveillance database (SVIG-TB), PTB cases older than 15 years notified from 2000 to 2012 in Continental Portugal were analyzed. Unsuccessful treatment included the WHO categories (failure, default, death and transferred out)...
October 3, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28970158/predictors-of-poor-treatment-outcomes-in-multidrug-resistant-tuberculosis-patients-a-retrospective-cohort-study
#4
Arshad Javaid, Irfan Ullah, Haleema Masud, Anila Basit, Waqas Ahmad, Zahid Ahmad Butt, Muhammad Qasim
OBJECTIVES: We aimed to determine the characteristics, treatment outcomes and risk factors for poor treatment outcomes among multidrug-resistant tuberculosis (MDR-TB) patients in the Khyber Pakhtunkhwa province, Pakistan. METHODS: A retrospective cohort study including all patients with MDR-TB attended at the MDR-TB unit in Peshawar was conducted between January 2012 and April 2014. Patients were followed until an outcome of TB treatment was recorded as successful (cured or completed) or unsuccessful...
September 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28892934/why-do-patients-undergoing-chronic-obstructive-pulmonary-disease-treatment-turn-defaulters-a-follow-up-study-in-a-tertiary-care-hospital-in-jamnagar-india
#5
Amrita Sarkar, Abhay Javia, Pradeep Pithadia, Dipesh Parmar
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD), a progressive respiratory illness requiring long-term treatment, is a significant cause of morbidity, mortality and economic burden on the family as well as the country. In the tertiary health care facility where the study was carried out, it was observed that many COPD patients did not come for regular follow up. In these patients, treatment interruption may lead to increased morbidity and mortality. AIM: This study aimed to find out the reasons for defaulting follow up and treatment in COPD patients...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28858089/adherence-tolerability-and-outcome-after-36-months-of-isoniazid-preventive-therapy-in-2-rural-clinics-of-swaziland-a-prospective-observational-feasibility-study
#6
MULTICENTER STUDY
Yolanda Mueller, Qhubekani Mpala, Bernhard Kerschberger, Barbara Rusch, Gugu Mchunu, Sikhathele Mazibuko, Maryline Bonnet
Although efficacy of 36 months isoniazid preventive therapy (IPT) among HIV-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings.This is a prospective observational cohort study conducted in 2 primary care rural clinics in Swaziland.After negative tuberculosis symptom screening, patients either with the positive tuberculin skin test (TST) or after tuberculosis treatment were initiated on IPT for 144 weeks. In addition to routine clinic visits, adherence was assessed every semester...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28836653/disease-and-treatment-related-factors-associated-with-tuberculosis-treatment-default-in-khartoum-state-sudan-a-case-control-study
#7
Ahmed O A Ali, Martin H Prins
Defaulting on tuberculosis (TB) treatment remains a challenge to controlling TB. This case-control study aimed to identify determinants of treatment default among TB patients attending treatment clinics in Khartoum State from May to July 2011. Cases were TB patients who defaulted on treatment and controls were those who completed treatment. Of the 2727 TB patients attending the clinics, 328 (14%) had defaulted. Of these, 185 had resumed treatment before data collection and 143 had not and were eligible as cases...
August 20, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28776529/treatment-outcome-of-patients-having-extensively-drug-resistant-tuberculosis-in-gujarat-india
#8
Krunal Prajapati, Vishal Mishra, Mira Desai, Rajesh Solanki, Purvi Naik
BACKGROUND: To investigate the factors affecting treatment outcome of extensively drug resistant tuberculosis (XDR-TB) in Gujarat, India. METHODS: A prospective, observational study was conducted on patients with XDR TB from January 2012 to October 2016. Details of demography, clinical symptoms, sputum/culture and radiological examination, drug treatment, adverse drug reactions (ADRs) and treatment outcome were recorded in pretested case record form (CRF). Data was analyzed using Fisher's exact test and paired student's t test...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28748003/patient-attitudes-towards-community-based-tuberculosis-dot-and-adherence-to-treatment-in-an-urban-setting-kampala-uganda
#9
Sempeera Hassard, Anguzu Ronald, Kawooya Angella
INTRODUCTION: High Tuberculosis treatment default rate (17%) and sub-optimal treatment completion rates (45%) has burdened Kampala. Nevertheless, there are observable increase in the number of patients on TB DOT; from 6% to 29% in two consecutive annual reports. The main objective was to determine the association of TB patient attitudes towards community-based observers on the TB drug adherence on directly observed treatment for TB in Kampala. METHODS: A cross-sectional study was carried out in Lubaga division, Kampala...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28727473/delay-in-initiation-of-treatment-after-diagnosis-of-pulmonary-tuberculosis-in-primary-health-care-setting-eight-year-cohort-analysis-from-district-faridabad-haryana-north-india
#10
Shashi Kant, Arvind K Singh, Giridara G Parmeshwaran, Partha Haldar, Sumit Malhotra, Ravneet Kaur
INTRODUCTION: Delay in initiation of tuberculosis (TB) treatment may have a tremendous impact on disease transmission, development of drug resistance, poor outcome and overall survival of TB patients. The delay can occur at various levels. Delay in initiation of treatment after diagnosis is mostly due to health system failure and has immense programmatic implications. It has not been studied extensively in the Indian setting. METHODS: The authors did a cohort analysis of all TB patients initiated on treatment from two primary health centres (PHCs) at Ballabgarh Health and Demographic Surveillance System between January 2007 and December 2014...
July 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28712668/treatment-outcomes-of-multidrug-resistant-tuberculosis-patients-in-zhejiang-china-2009-2013
#11
L Zhang, Q Meng, S Chen, M Zhang, B Chen, B Wu, G Yan, X Wang, Z Jia
OBJECTIVES: To examine treatment outcomes and factors associated with poor outcome of multidrug-resistant (MDR) tuberculosis (TB) in China. METHODS: We conducted a prospective observational cohort study including consecutive patients with MDR-TB between 2009 and 2013 in six regions of Zhejiang province. Patients were prescribed treatments by infectious disease specialists, and treatment outcomes were recorded. Sociodemographic characteristics were obtained through a structured questionnaire...
July 13, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28693508/unsuccessful-tb-treatment-outcomes-with-a-focus-on-hiv-co-infected-cases-a-cross-sectional-retrospective-record-review-in-a-high-burdened-province-of-south-africa
#12
M C Engelbrecht, N G Kigozi, P Chikobvu, S Botha, H C J van Rensburg
BACKGROUND: South Africa did not meet the MDG targets to reduce TB prevalence and mortality by 50% by 2015, and the TB cure rate remains below the WHO target of 85%. TB incidence in the country is largely fuelled by the HIV epidemic, and co-infected patients are more likely to have unsuccessful TB treatment outcomes. This paper analyses the demographic and clinical characteristics of new TB patients with unsuccessful treatment outcomes, as well as factors associated with unsuccessful treatment outcomes for HIV co-infected patients...
July 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28652801/outcome-of-tuberculosis-treatment-and-its-predictors-among-hiv-infected-patients-in-southwest-ethiopia
#13
Adane Teshome Kefale, Yeniewa Kerie Anagaw
BACKGROUND: Co-infection with HIV challenges treatment of tuberculosis (TB) and worsens the outcome. This study aimed to assess the outcome of TB treatment and its predictors among HIV infected patients at Mizan-Tepi University Teaching Hospital (MTUTH), Ethiopia. METHODS: Medical records of 188 TB/HIV co-infected patients who attended the TB clinic of MTUTH from September 2012 to December 2015 were reviewed from March 14 to April 1, 2016. The primary endpoints of the study were treatment outcome of TB and its predictors...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28611374/efficacy-and-safety-of-mycobacterium-indicus-pranii-as-an-adjunct-therapy-in-category-ii-pulmonary-tuberculosis-in-a-randomized-trial
#14
Surendra K Sharma, Kiran Katoch, Rohit Sarin, Raman Balambal, Nirmal Kumar Jain, Naresh Patel, Kolluri J R Murthy, Neeta Singla, P K Saha, Ashwani Khanna, Urvashi Singh, Sanjiv Kumar, A Sengupta, J N Banavaliker, D S Chauhan, Shailendra Sachan, Mohammad Wasim, Sanjay Tripathi, Nilesh Dutt, Nitin Jain, Nalin Joshi, Sita Ram Raju Penmesta, Sumanlatha Gaddam, Sanjay Gupta, Bakulesh Khamar, Bindu Dey, Dipendra K Mitra, Sunil K Arora, Sangeeta Bhaskar, Rajni Rani
Prolonged treatment of tuberculosis (TB) often leads to poor compliance, default and relapse, converting primary TB patients into category II TB (Cat IITB) cases, many of whom may convert to multi-drug resistant TB (MDR-TB). We have evaluated the immunotherapeutic potential of Mycobacterium indicus pranii (MIP) as an adjunct to Anti-Tubercular Treatment (ATT) in Cat II pulmonary TB (PTB) patients in a prospective, randomized, double blind, placebo controlled, multicentric clinical trial. 890 sputum smear positive Cat II PTB patients were randomized to receive either six intra-dermal injections (2 + 4) of heat-killed MIP at a dose of 5 × 10(8) bacilli or placebo once in 2 weeks for 2 months...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28529205/effectiveness-and-safety-of-bedaquiline-containing-regimens-in-the-treatment-of-mdr-and-xdr-tb-a-multicentre-study
#15
Sergey E Borisov, Keertan Dheda, Martin Enwerem, Rodolfo Romero Leyet, Lia D'Ambrosio, Rosella Centis, Giovanni Sotgiu, Simon Tiberi, Jan-Willem Alffenaar, Andrey Maryandyshev, Evgeny Belilovski, Shashank Ganatra, Alena Skrahina, Onno Akkerman, Alena Aleksa, Rohit Amale, Janina Artsukevich, Judith Bruchfeld, Jose A Caminero, Isabel Carpena Martinez, Luigi Codecasa, Margareth Dalcolmo, Justin Denholm, Paul Douglas, Raquel Duarte, Aliasgar Esmail, Mohammed Fadul, Alexey Filippov, Lina Davies Forsman, Mina Gaga, Julia-Amaranta Garcia-Fuertes, José-María García-García, Gina Gualano, Jerker Jonsson, Heinke Kunst, Jillian S Lau, Barbara Lazaro Mastrapa, Jorge Lazaro Teran Troya, Selene Manga, Katerina Manika, Pablo González Montaner, Jai Mullerpattan, Suzette Oelofse, Martina Ortelli, Domingo Juan Palmero, Fabrizio Palmieri, Antonella Papalia, Apostolos Papavasileiou, Marie-Christine Payen, Emanuele Pontali, Carlos Robalo Cordeiro, Laura Saderi, Tsetan Dorji Sadutshang, Tatsiana Sanukevich, Varvara Solodovnikova, Antonio Spanevello, Sonam Topgyal, Federica Toscanini, Adrian R Tramontana, Zarir Farokh Udwadia, Pietro Viggiani, Veronica White, Alimuddin Zumla, Giovanni Battista Migliori
Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are lacking. This study aimed to evaluate the safety and effectiveness of bedaquiline-containing regimens in a large, retrospective, observational study conducted in 25 centres and 15 countries in five continents.428 culture-confirmed MDR-TB cases were analysed (61.5% male; 22.1% HIV-positive, 45.6% XDR-TB). MDR-TB cases were admitted to hospital for a median (interquartile range (IQR)) 179 (92-280) days and exposed to bedaquiline for 168 (86-180) days...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28432172/why-tuberculosis-control-programmes-fail-role-of-microlevel-and-macrolevel-factors-an-analysis-from-india
#16
Sudip Bhattacharya, Amarjeet Singh
India accounts for one-fourth of the global tuberculosis (TB) burden. The National TB Program was started in 1962. Over a period of time, some lacunae such as poor case detection rate and incomplete treatment were observed. Later, the government formulated the Revised National Tuberculosis Control Program (RNTCP), which achieved a case detection rate of 70% and a cure rate of 85%. Still, the problem of relapse and defaulter cases persists. In 2014, 6% defaulter cases were reported from India. RNTCP has also focused on microlevel aspects, that is, newer diagnostics such as GenXpert, line probe assay and medicines such as bedaquiline for drug-resistant TB...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28392916/treatment-outcomes-of-tuberculosis-patients-in-nigist-eleni-mohammed-general-hospital-hosanna-southern-nations-nationalities-and-peoples-region-ethiopia-a-five-year-june-2009-to-august-2014-retrospective-study
#17
Tigist Mohammed, Kidist Daniel, Degefa Helamo, Taye Leta
BACKGROUND: Tuberculosis remains to be a major public health problem among under developed world due to delay in detection and treatment of patients with active TB. In Ethiopia, tuberculosis has been recognized as a major public health problem for more than fifty years. OBJECTIVE: The main objective of this study was to determine treatment outcomes and associated factors among TB patients attending Nigist Eleni Mohammed General Hospital, Hosanna, SNNPR, Ethiopia...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28332365/social-and-clinical-characteristics-of-immigrants-with-tuberculosis-in-south-korea
#18
Gee Ho Min, Young Kim, Jong Seok Lee, Jee Youn Oh, Gyu Young Hur, Young Seok Lee, Kyung Hoon Min, Sung Yong Lee, Je Hyeong Kim, Chol Shin, Seung Heon Lee
PURPOSE: To determine the social and clinical characteristics of immigrants with tuberculosis (TB) in South Korea. MATERIALS AND METHODS: The registered adult TB patients who were diagnosed and treated in Korea Medical Centers from January 2013 to December 2015 were analyzed retrospectively. A total of 105 immigrants with TB were compared to 932 native Korean TB patients. RESULTS: Among these 105 immigrants with TB, 86 (82%) were Korean-Chinese...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28315657/magnitude-and-determinants-of-adverse-treatment-outcomes-among-tuberculosis-patients-registered-under-revised-national-tuberculosis-control-program-in-a-tuberculosis-unit-wardha-central-india-a-record-based-cohort-study
#19
Anuj Mundra, Pradeep R Deshmukh, Ajay Dawale
INTRODUCTION: Deaths, defaults, relapses, and treatment failures have made the control of TB difficult across the globe. METHODOLOGY: This study is a record-based follow-up of a cohort of patients registered under Revised National Tuberculosis Control Program in the year 2014 in Wardha Tuberculosis Unit, India. Data was collected from the records available at the District Tuberculosis Office. RESULTS: Data of 510 patients was analyzed. The sputum conversion rate was 88%...
June 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28187753/survival-of-people-living-with-hiv-who-defaulted-from-tuberculosis-treatment-in-a-cohort-recife-brazil
#20
R Cunha, M Maruza, U R Montarroyos, I Coimbra, D de B Miranda-Filho, M de F Albuquerque, H R Lacerda, Raa Ximenes
BACKGROUND: Tuberculosis is a serious public health problem worldwide. It is the leading cause of death amongst people living with HIV, and default from tuberculosis (TB) treatment in people living with HIV increases the probability of death. The aim of this study was to estimate the survival probability of people living with HIV who default treatment for TB compared to those who complete the treatment. METHODS: This was a longitudinal cohort study of people living with HIV, from June 2007 to December 2013 with two components: a retrospective (for those who started tuberculosis treatment before 2013 for whom failure (death) or censoring occurred before 2013), and prospective (those who started tuberculosis treatment at any time between 2007 and June 2013 and for whom death or censoring occurred after the beginning of 2013), at two referral hospitals for people living with HIV (Correia Picanço Hospital - HCP and at Hospital Universitário Oswaldo Cruz - HUOC), in Recife/PE...
February 10, 2017: BMC Infectious Diseases
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