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https://www.readbyqxmd.com/read/29606091/a-cross-sectional-study-of-tuberculosis-drug-resistance-among-previously-treated-patients-in-a-tertiary-hospital-in-accra-ghana-public-health-implications-of-standardized-regimens
#1
Audrey Forson, Awewura Kwara, Samuel Kudzawu, Michael Omari, Jacob Otu, Florian Gehre, Bouke de Jong, Martin Antonio
BACKGROUND: Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. METHODS: This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29579428/socio-demographic-profile-and-outcome-of-tb-patients-registered-at-dtc-rewa-of-central-india
#2
Rohit Trivedi Rohit, Anjana Niranjan, Paharam Adhikari Pawan
BACKGROUND: Tuberculosis is a specific infectious disease caused by Mycobacterium tuberculosis. The disease is usually chronic with cardinal features such as persistent cough with or without expectoration, intermittent fever, and loss of appetite, weight loss, chest pain and hemoptysis. OBJECTIVE: (1) To assess the socio-demographic profile of the patients attending DOTS Center. (2) To assess outcome of treatment under DOTS Center. METHODOLOGY: This is a Prospective Longitudinal study conducted among the patients attending DOTS center of DTC located at S...
April 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29554144/tuberculosis-treatment-outcomes-in-ethiopia-from-2003-to-2016-and-impact-of-hiv-co-infection-and-prior-drug-exposure-a-systematic-review-and-meta-analysis
#3
Setegn Eshetie, Mucheye Gizachew, Animut Alebel, Dick van Soolingen
BACKGROUND: Knowledge of tuberculosis (TB) treatment outcomes is substantially needed to assess the performance of national TB controls programs (NTPs). To date, the overall estimates of treatment outcomes have not been determined in Ethiopia. Therefore, this meta-analysis was undertaken to produce pooled estimates of TB treatment outcomes and to analyze the impact of prior anti-TB drug exposure and HIV co-infection. METHODS: Potentially relevant studies were retrieved from PubMed, EMBASE, and MEDLINE online databases...
2018: PloS One
https://www.readbyqxmd.com/read/29516002/treatment-outcomes-of-tuberculosis-at-asella-teaching-hospital-ethiopia-ten-years-retrospective-aggregated-data
#4
Ketema Tafess, Teresa Kisi Beyen, Adugna Abera, Geremew Tasew, Shimelis Mekit, Solomon Sisay, Legesse Tadesse, Gilman K H Siu
Background: Directly Observed Treatment Short-course (DOTS) has been one of the major strategies to combat the epidemic of tuberculosis (TB) globally. This study aimed to evaluate TB treatment outcomes between September 2004 and July 2014 under the DOTS program at one of the largest public hospitals in Ethiopia. Methods: A retrospective data of TB patients registered at Asella Teaching Hospital between September 2004 and July 2014 were obtained from hospital registry...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29485739/sustainable-survival-for-adolescents-living-with-hiv-do-sdg-aligned-provisions-reduce-potential-mortality-risk
#5
Lucie Cluver, Marija Pantelic, Mark Orkin, Elona Toska, Sally Medley, Lorraine Sherr
INTRODUCTION: The Sustainable Development Goals (SDGs) present a groundbreaking global development agenda to protect the most vulnerable. Adolescents living with HIV in Sub-Saharan Africa continue to experience extreme health vulnerabilities, but we know little about the impacts of SDG-aligned provisions on their health. This study tests associations of provisions aligned with five SDGs with potential mortality risks. METHODS: Clinical and interview data were gathered from N = 1060 adolescents living with HIV in rural and urban South Africa in 2014 to 2015...
February 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29412320/effects-of-social-protection-on-tuberculosis-treatment-outcomes-in-low-or-middle-income-and-in-high-burden-countries-systematic-review-and-meta-analysis
#6
Kaio Vinicius Freitas de Andrade, Joilda Silva Nery, Ramon Andrade de Souza, Susan Martins Pereira
Tuberculosis (TB) is a poverty infectious disease that affects millions of people worldwide. Evidences suggest that social protection strategies (SPS) can improve TB treatment outcomes. This study aimed to synthesize such evidences through systematic literature review and meta-analysis. We searched for studies conducted in low- or middle-income and in high TB-burden countries, published during 1995-2016. The review was performed by searching PubMed/MEDLINE, Scopus, Web of Science, ScienceDirect and LILACS. We included only studies that investigated the effects of SPS on TB treatment outcomes...
February 5, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29310659/the-impact-of-rural-residence-and-hiv-infection-on-poor-tuberculosis-treatment-outcomes-in-a-large-urban-hospital-a-retrospective-cohort-analysis
#7
Aishatu Lawal Adamu, Muktar H Aliyu, Najiba Aliyu Galadanci, Baba Maiyaki Musa, Umar Muhammad Lawan, Usman Bashir, Ibrahim Abubakar
BACKGROUND: Successful tuberculosis (TB) treatment is essential to effective TB control. TB-HIV coinfection, social determinants and access to services influenced by rural residence can affect treatment outcome. We examined the separate and joint effects of rural residence and HIV infection on poor treatment outcome among patients enrolled in a large TB treatment centre in Kano, Nigeria. METHODS: We retrospectively analysed a cohort of patients with TB enrolled in a large urban TB clinic in northern Nigeria, from January 2010 to December 2014...
January 8, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29302535/sputum-smear-grading-and-treatment-outcome-among-directly-observed-treatment-short-course-patients-of-tuberculosis-unit-jagdalpur-bastar
#8
Kishor Parashramji Brahmapurkar, Vaishali K Brahmapurkar, Sanjay P Zodpey
Introduction: Tuberculosis (TB) is a major global health problem. In 2014, worldwide, 1.5 million deaths were reported from TB. The study was planned to assess sputum smear grading and treatment outcome among TB patients attending tuberculosis unit (TU), Jagdalpur of Bastar district in Chhattisgarh. Materials and Methods: It was a record-based analysis for the year 2014 data from TU, Jagdalpur, Bastar of Chhattisgarh. Statistical Analysis Used: Data entry and analysis were done using STATA/SE 14...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29302148/association-of-risk-factors-and-drug-resistance-pattern-in-tuberculosis-patients-in-north-india
#9
Pallavi Sinha, G N Srivastava, Anamika Gupta, Shampa Anupurba
Context: India is one of the high tuberculosis (TB) burden countries in the world. Improper implementation in the guidelines for the management of TB and high rate of defaults on the part of the patients are most important risk factors for the development of multi-drug resistant TB. Aims: This study examines the drug resistance profile and the effect of demographic, clinical and behavioral risk factors on the prevalence of TB and multidrug resistance (MDR) in north India...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29237401/six-monthly-appointment-spacing-for-clinical-visits-as-a-model-for-retention-in-hiv-care-in-conakry-guinea-a-cohort-study
#10
Cavin Epie Bekolo, Abdourahimi Diallo, Mit Philips, Joseph-Desire Yuma, Letizia Di Stefano, Stéphanie Drèze, Jerome Mouton, Youssouf Koita, Ousseni W Tiomtore
BACKGROUND: The outbreak of the Ebola virus disease (EVD) in 2014 led to massive dropouts in HIV care in Guinea. Meanwhile, Médecins Sans Frontières (MSF) was implementing a six-monthly appointment spacing approach adapted locally as Rendez-vous de Six Mois (R6M) with an objective to improve retention in care. We sought to evaluate this innovative model of ART delivery in circumstances where access to healthcare is restricted. METHODS: A retrospective cohort study in 2014 of the outcome of a group of stable patients (viral load ≤1000 copies/μl) enrolled voluntarily in R6M compared with a group of stable patients continuing standard one to three monthly visits in Conakry...
December 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29233121/do-retreatment-tuberculosis-patients-need-special-treatment-response-follow-up-beyond-the-standard-regimen-finding-of-five-year-retrospective-study-in-pastoralist-setting
#11
Fentabil Getnet, Henok Sileshi, Wubareg Seifu, Selam Yirga, Abere Shiferaw Alemu
BACKGROUND: Treatment outcomes serve as proxy measures of the quality of tuberculosis treatment provided by the health care system, and it is essential to evaluate the effectiveness of Directly Observed Therapy-Short course program in controlling the disease, and reducing treatment failure, default and death. Hence, we evaluated tuberculosis treatment success rate, its trends and predictors of unsuccessful treatment outcome in Ethiopian Somali region where 85% of its population is pastoralist...
December 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29173226/drug-addiction-and-alcoholism-as-predictors-for-tuberculosis-treatment-default-in-brazil-a-prospective-cohort-study
#12
M R Silva, J C Pereira, R R Costa, J A Dias, M D C Guimarães, I C G Leite
This study aimed to evaluate the risk factors for tuberculosis (TB) treatment default in a priority city for disease control in Brazil. A cohort of TB cases diagnosed from 2008 to 2009 was followed up from patients' entry into three outpatient sites, in Juiz de Fora, Minas Gerais (Brazil), until the recording of the outcomes. Drug addiction, alcoholism and treatment site appeared to be independently associated with default. Current users of crack as the hardest drug (odds ratio (OR) 12·25, 95% confidence interval (CI) 3·04-49·26) were more likely to default than other hard drug users (OR 5·67, 95% CI 1·34-24·03), former users (OR 4·12, 95% CI 1·11-15·20) and those not known to use drugs (reference group)...
December 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29171450/treatment-outcome-of-tuberculosis-patients-under-directly-observed-treatment-short-course-and-its-determinants-in-shangla-khyber-pakhtunkhwa-pakistan-a-retrospective-study
#13
Tauseef Ahmad, Muhammad Khan, Muhammad Mumtaz Khan, Eyasu Ejeta, Manoochehr Karami, Chinenyenwa Ohia
BACKGROUND: Tuberculosis (TB) is one of the leading causes of morbidity and mortality in Pakistan. Assessment of TB treatment outcomes, monitoring and evaluation of its risk factors in Directly Observed Treatment Short Course (DOTS) are among the major indicators of the performance of a national TB control program. Even though Pakistan ranks 5th among the 22 high-TB burden countries, there are no available data in this regard. METHODS: Institution-based retrospective study was conducted to determine the treatment outcome of TB patients and investigate associated risk factors at District Head Quarter Hospital Shangla, Khyber-Pakhtunkhwa, Pakistan...
October 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29110871/prevalence-of-rifampicin-resistant-mycobacterium-tuberculosis-among-human-immunodeficiency-virus-seropositive-patients-and-their-treatment-outcomes
#14
C K Vidyaraj, A Chitra, S Smita, M Muthuraj, S Govindarajan, B Usharani, S Anbazhagi
Multidrug resistant (MDR) and extensively drug resistant tuberculosis (TB) are a threat to the TB control programs in developing countries, and the situation is worsened by the human immunodeficiency virus (HIV) pandemic. This study was performed to correlate treatment outcome with the resistance patterns in HIV-seropositive patients coinfected with pulmonary TB. Sputum specimens were collected from 1643 HIV-seropositive patients and subjected to microscopy and liquid culture for TB. The smear- and culture-positive Mycobacterium tuberculosis isolates were subjected to Genotype MTBDRplus assay version 2...
December 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/29098997/adverse-drug-reactions-and-treatment-outcome-analysis-of-dots-plus-therapy-of-mdr-tb-patients-at-district-tuberculosis-centre-a-four-year-retrospective-study
#15
Arif I Dela, Nitish Kumar D Tank, Anil P Singh, Kiran G Piparva
BACKGROUND: Treatment of multidrug-resistant tuberculosis (MDR-TB) requires the use of expensive and toxic second-line anti-tubercular drugs which are given for a longer duration. Adverse drug reactions (ADRs) of second-line antitubercular drugs affect compliance and thereby treatment outcome. We set out to analyze ADRs and treatment outcome of MDR-TB patients receiving directly observed treatments plus therapy. MATERIALS AND METHODS: A retrospective study of registered MDR-TB cases at district tuberculosis center during 2010-2014 was performed...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29090653/tuberculous-pyelonephritis-in-children-three-case-reports
#16
Nimisha Arora, Abhijeet Saha, Manpreet Kaur
Tuberculous pyelonephritis is rare in children; three case reports are presented. Case 1 was an 11-year-old girl with a previous history of pulmonary tuberculosis who presented with flank pain and fever for 10 days. An ultrasound suggested focal pyelonephritis, and a contrast-enhanced computed tomography (CECT) scan demonstrated acute focal pyelonephritis and a perinephric collection. Mycobacterium tuberculosis was cultured in the urine. She responded well to anti-tuberculous treatment (ATT). Case 2 was a 13-year-old boy who presented with fever, haematuria, burning micturition, proteinuria (3+) and cervical lymphadenopathy...
November 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29036618/unsuccessful-treatment-in-pulmonary-tuberculosis-factors-and-a-consequent-predictive-model
#17
Ana Costa-Veiga, Teodoro Briz, Carla Nunes
Background: Cure is particularly valuable in pulmonary cases (PTB), as unsuccessful treatment fuels incidence and resistance to antibiotics. This study aims to identify individual factors of PTB unsuccessful treatment in Portugal and to develop a consequent predictive model. Methods: Using the Portuguese TB surveillance database (SVIG-TB), PTB cases older than 15 years notified from 2000 to 2012 in Continental Portugal were analyzed. Unsuccessful treatment included the WHO categories (failure, default, death and transferred out)...
October 3, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28970158/predictors-of-poor-treatment-outcomes-in-multidrug-resistant-tuberculosis-patients-a-retrospective-cohort-study
#18
A Javaid, I Ullah, H Masud, A Basit, W Ahmad, Z A Butt, M Qasim
OBJECTIVES: We aimed to determine the characteristics, treatment outcomes and risk factors for poor treatment outcomes among multidrug-resistant (MDR) tuberculosis (TB) patients in Khyber Pakhtunkhwa province, Pakistan. METHODS: A retrospective cohort study including all patients with MDR-TB who sought care at the MDR-TB unit in Peshawar was conducted between January 2012 and April 2014. Patients were followed until an outcome of TB treatment was recorded as successful (cured or completed) or unsuccessful...
September 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28895659/implementation-strategies-for-health-systems-in-low-income-countries-an-overview-of-systematic-reviews
#19
REVIEW
Tomas Pantoja, Newton Opiyo, Simon Lewin, Elizabeth Paulsen, Agustín Ciapponi, Charles S Wiysonge, Cristian A Herrera, Gabriel Rada, Blanca Peñaloza, Lilian Dudley, Marie-Pierre Gagnon, Sebastian Garcia Marti, Andrew D Oxman
BACKGROUND: A key function of health systems is implementing interventions to improve health, but coverage of essential health interventions remains low in low-income countries. Implementing interventions can be challenging, particularly if it entails complex changes in clinical routines; in collaborative patterns among different healthcare providers and disciplines; in the behaviour of providers, patients or other stakeholders; or in the organisation of care. Decision-makers may use a range of strategies to implement health interventions, and these choices should be based on evidence of the strategies' effectiveness...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28858089/adherence-tolerability-and-outcome-after-36-months-of-isoniazid-preventive-therapy-in-2-rural-clinics-of-swaziland-a-prospective-observational-feasibility-study
#20
MULTICENTER STUDY
Yolanda Mueller, Qhubekani Mpala, Bernhard Kerschberger, Barbara Rusch, Gugu Mchunu, Sikhathele Mazibuko, Maryline Bonnet
Although efficacy of 36 months isoniazid preventive therapy (IPT) among HIV-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings.This is a prospective observational cohort study conducted in 2 primary care rural clinics in Swaziland.After negative tuberculosis symptom screening, patients either with the positive tuberculin skin test (TST) or after tuberculosis treatment were initiated on IPT for 144 weeks. In addition to routine clinic visits, adherence was assessed every semester...
September 2017: Medicine (Baltimore)
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