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https://www.readbyqxmd.com/read/27917196/five-years-retrospective-cohort-analysis-of-treatment-outcomes-of-tb-hiv-patients-at-a-pepfar-dots-centre-in-south-eastern-nigeria
#1
Omotowo I Babatunde, Ekwueme O Christiandolus, Eke C Bismarck, Obi I Emmanuel, Agunwa C Chike, Eyisi I Gabriel
BACKGROUND: Human immunodeficiency virus (HIV) associated tuberculosis (TB) remains a major global public health challenge, with an estimated 1.4 million patients worldwide. Co-infection with HIV leads to challenges in the diagnosis and treatment of patients. OBJECTIVES: The aim of this study was to assess treatment outcomes of a cohort of smear positive TB-HIV co-infected patients over a five-year study period. METHODS: A retrospective cohort study of 600 smear-positive tuberculosis patients registered at the chest unit of the University of Nigeria Teaching Hospital, Enugu from January 2008 to December 2012 was done...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27894985/factors-influencing-treatment-default-among-tuberculosis-patients-in-a-high-burden-province-of-south-africa
#2
G Kigozi, C Heunis, P Chikobvu, S Botha, D van Rensburg
OBJECTIVE: To determine and describe the factors influencing treatment default of tuberculosis (TB) patients in the Free State Province of South Africa. METHODS: We conducted a retrospective record review of pulmonary TB cases-older than 15 years, with a recorded pre-treatment smear result-captured in the electronic TB register (ETR.net) between 2003 and 2012. The demographic and clinical characteristics of defaulters were described. Multiple logistic regression technique were used to determine the factors associated with treatment default...
November 25, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27865237/smoked-and-smokeless-tobacco-use-among-pulmonary-tuberculosis-patients-under-rntcp-in-urban-puducherry-india
#3
Veerakumar Arumugam Mariappan, Swaroop Kumar Sahu, Sonali Sarkar, Shivanand Kattimani, Govindarajan Soundappan
BACKGROUND: Smoking is associated with unfavourable treatment outcomes like failures and defaults among the TB patients. OBJECTIVES: To study the prevalence and pattern of tobacco use among the pulmonary tuberculosis (PTB) patients in urban Pondicherry and study the association of various socio-demographic variables with current smoked and smokeless tobacco users. METHODS: A cross-sectional study was conducted among 235 PTB patients from 6 randomly selected urban PHCs of Pondicherry from Jan 2013 to March 2014...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27812166/survival-outcomes-in-a-pediatric-antiretroviral-treatment-cohort-in-southern-malawi
#4
Jason C Brophy, Michael T Hawkes, Edson Mwinjiwa, Gabriel Mateyu, Sumeet K Sodhi, Adrienne K Chan
BACKGROUND: Pediatric uptake and outcomes in antiretroviral treatment (ART) programmes have lagged behind adult programmes. We describe outcomes from a population-based pediatric ART cohort in rural southern Malawi. METHODS: Data were analyzed on children who initiated ART from October/2003 -September/2011. Demographics and diagnoses were described and survival analyses conducted to assess the impact of age, presenting features at enrolment, and drug selection. RESULTS: The cohort consisted of 2203 children <15 years of age...
2016: PloS One
https://www.readbyqxmd.com/read/27801499/six-month-therapy-for-abdominal-tuberculosis
#5
REVIEW
Sophie Jullien, Siddharth Jain, Hannah Ryan, Vineet Ahuja
BACKGROUND: Tuberculosis (TB) of the gastrointestinal tract and any other organ within the abdominal cavity is abdominal TB, and most guidelines recommend the same six-month regimen used for pulmonary TB for people with this diagnosis. However, some physicians are concerned whether a six-month treatment regimen is long enough to prevent relapse of the disease, particularly in people with gastrointestinal TB, which may sometimes cause antituberculous drugs to be poorly absorbed. On the other hand, longer regimens are associated with poor adherence, which could increase relapse, contribute to drug resistance developing, and increase costs to patients and health providers...
November 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27796102/experiences-of-patients-having-tuberculosis-tb-regarding-the-use-of-directly-observed-treatment-short-course-dots-in-the-north-west-province-south-africa
#6
Maserapelo G Serapelwane, Mashudu Davhana-Maselesele, Gaboipolelwe M Masilo
BACKGROUND: Tuberculosis (TB) management remains a major challenge despite the implementation of Directly Observed Treatment Short-Course (DOTS). Some of the challenges include defaulting treatment, low TB cure rates and relapse after patients had been treated under DOTS. OBJECTIVES: This study explored and described experiences of patients having TB regarding the use of DOTS in Doctor Ruth Segomotsi Mompati District of North West Province, South Africa. The study describes and recommends support required by patients having TB who are using DOTS...
September 27, 2016: Curationis
https://www.readbyqxmd.com/read/27725046/treatment-outcomes-of-daily-anti-tuberculosis-treatment-in-hiv-infected-patients-seeking-care-at-a-private-clinic-in-india
#7
R Parchure, V Kulkarni, R Gangakhedkar, S Swaminathan
SETTING: Little is known about outcomes of patients co-infected with human immunodeficiency virus (HIV) and tuberculosis (TB) who are treated in the private sector in India. OBJECTIVE: To describe the treatment outcomes of daily anti-tuberculosis treatment (ATT) and their determinants among HIV-TB co-infected patients treated at a private clinic in Pune, India. DESIGN: Data on adult HIV-TB co-infected patients treated with daily ATT were analysed using logistic regression and Cox model to assess risk factors for default and death...
October 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27680048/differences-in-the-clinical-epidemiological-profile-between-new-cases-of-tuberculosis-and-retreatment-cases-after-default
#8
Aylana de Souza Belchior, Ricardo Alexandre Arcêncio, Evelyne Marie Therese Mainbourg
OBJECTIVE: To identify the socioeconomic and clinical-epidemiological factors related to tuberculosis in new cases and retreatment cases. METHOD: Comparative study with 126 patients, of which 42 were retreatment cases after default attended in a reference center, and 84 were new cases completing the first treatment and treated in Basic Health Units. The collection of primary data was through interview, and of secondary data by records of the Notifiable Diseases Information System...
July 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27660541/treatment-outcomes-of-patients-with-multidrug-resistant-tuberculosis-mdr-tb-compared-with-non-mdr-tb-infections-in-peninsular-malaysia
#9
Omar Salad Elmi, Habsah Hasan, Sarimah Abdullah, Mat Zuki Mat Jeab, Zilfalil Ba, Nyi Nyi Naing
BACKGROUND: Treating patients with multidrug-resistant tuberculosis (MDR-TB) strains is more complicated, complex, toxic, expensive, than treating patients with susceptible TB strains. This study aims to compare the treatment outcomes and potential factors associated between patients with MDR-TB and non MDR TB infections in peninsular Malaysia. METHODS: This study was a retrospective cohort study. Data were collected from the medical records of all registered MDR-TB patients and Non-MDR-TB patients at five TB hospitals in peninsular Malaysia from January 2010 to January 2014...
July 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27625444/comparative-study-of-clinico-bacterio-radiological-profile-and-treatment-outcome-of-smokers-and-nonsmokers-suffering-from-pulmonary-tuberculosis
#10
Deepti Rathee, Piyush Arora, Manoj Meena, Rohit Sarin, Pitambar Chakraborty, Anand Jaiswal, Mukesh Goyal
INTRODUCTION: Tuberculosis (TB) is one of the leading causes of death and disease worldwide. Tobacco smoking has been linked as a risk factor for TB. This study was aimed to affirm the strength of association between smoking and pulmonary TB. MATERIALS AND METHODS: Pulmonary TB patients aged between 18 and 65 years were enrolled and followed-up until treatment completion. Two consecutive sputum smears were examined from each patient for the presence of acid-fast bacilli (AFB) using Ziehl-Neelsen technique...
September 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27553661/tuberculosis-treatment-outcome-and-associated-factors-among-smear-positive-pulmonary-tuberculosis-patients-in-afar-eastern-ethiopia-a-retrospective-study
#11
Tizazu Zenebe, Ermias Tefera
Evaluating the outcomes of tuberculosis treatment and understanding the specific reasons for unfavorable treatment outcome are important in evaluating the effectiveness of tuberculosis control program. A retrospective study was conducted to assess tuberculosis treatment outcomes and associated factors among smear positive pulmonary tuberculosis patients in zone-one health facilities of Afar regional state, Ethiopia. A total of 380 smear positive pulmonary tuberculosis patients' registration book recorded with complete information from Jan 2011 to Dec 2013 were analyzed...
August 21, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27528998/childhood-tuberculosis-in-malawi-caseload-diagnostic-practices-and-treatment-outcomes
#12
A D Harries, S M Graham, M M Weismuller, Njm Claessens, S Meijnen, N J Hargreaves, C Mwansambo, P N Kazembe, F M Salaniponi
There were 22,982 cases of TB registered in Malawi in 1998, of which 2739 (11.9%) were children. Children accounted for 11.3% of all case notifications with smear-positive pulmonary TB (PTB), 21.3% with smear-negative PTB and 15.9% with extrapulmonary TB (EPTB). A significantly higher proportion of TB cases were diagnosed in central hospitals. Only 45% of children completed treatment. There were high rates of death (17%), default (13%) and unknown treatment outcomes (21%). Treatment outcomes were worse in younger children and in children with smear-negative PTB...
December 2005: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27528959/shortfalls-identified-in-the-management-of-tuberculosis-for-mozambican-patients-obtaining-health-care-services-in-malawi
#13
Adamson S Muula, Yohane Nyasulu, Henry Feluzi, Collins Magalasi
We report findings of a pilot qualitative study in which we aimed to determine management gaps among TB patients from Mozambique obtaining health care services in Malawi. The study was conducted between April and May 2002 involved twelve health workers and 4 Mozambican patients. Semi-structured questionnaires were used and responses were followed up with in-depth interviews. Several areas of management gaps were identified. These included; language barrier if patients are formally referred with documents in Portuguese; lack of follow-up system in case of patients defaulting; no structured contact-tracing possibilities and no initiation of Isoniazid prophylaxis in the case of children living in households with a sputum smear positive adult case...
June 2003: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27510245/trends-in-tuberculosis-case-notification-and-treatment-outcomes-after-interventions-in-10-zones-of-ethiopia
#14
Z G Dememew, D Habte, M Melese, S D Hamusse, G Nigussie, N Hiruy, B Girma, Y Kassie, Y K Haile, D Jerene, P Suarez
SETTING: Amhara and Oromia Regions, Ethiopia. OBJECTIVE: To determine trends in case notification rates (CNRs) among new tuberculosis (TB) cases and treatment outcomes of sputum smear-positive (SS+) patients based on geographic setting, sex and age categories. METHODS: We undertook a trend analysis over a 4-year period among new TB cases reported in 10 zones using a trend test, a mean comparison t-test and one-way analysis of variance. RESULTS: The average CNR per 100 000 population was 128...
September 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27510244/an-integrated-community-tb-hiv-adherence-model-provides-an-alternative-to-dot-for-tuberculosis-patients-in-cape-town
#15
R Kaplan, J Caldwell, S Hermans, S Adriaanse, L Mtwisha, L-G Bekker, K Jennings, R Wood
SETTING: Cape Town, South Africa. OBJECTIVE: To evaluate anti-tuberculosis treatment outcomes and rate of antiretroviral therapy (ART) initiation using weekly community-based adherence support compared to daily directly observed therapy (DOT). METHODS: This was a retrospective analysis comparing two cohorts treated for tuberculosis (TB) in 70 TB clinics during 6-month periods before and after the introduction of a new adherence model comprising treatment literacy sessions during 2 weeks of DOT, followed by weekly home visits by community care workers to eligible patients managing their own treatment...
September 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27508140/clinical-predictors-of-streptomycin-vestibulotoxicity
#16
Miraj Ahmed, Anupam Mishra, Kamal Kumar Sawlani, Veerendra Verma, Rajiv Garg, Hitendra Prakash Singh, Sunil Kumar
The Global tuberculosis control is challenged with a growing resistance to antitubercular treatment (ATT) culminating in resistant (MDR/XDR) strains; an important factor being premature withdrawal of streptomycin owing to its morbidity particularly nephrotoxicity and cochleotoxicity as guidelines for their prevention exist. An attempt is made here to address the least recognized and most debilitating vestibular toxic effects of streptomycin and defining a vestibular-protocol for its early detection and progression...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27198545/poor-tuberculosis-treatment-outcomes-in-southern-mozambique-2011-2012
#17
Alberto L García-Basteiro, Durval Respeito, Orvalho J Augusto, Elisa López-Varela, Charfudin Sacoor, Victor G Sequera, Aina Casellas, Quique Bassat, Ivan Manhiça, Eusebio Macete, Frank Cobelens, Pedro L Alonso
BACKGROUND: In Mozambique, there is limited data regarding the monitoring of Tuberculosis (TB) treatment results and determinants of adverse outcomes under routine surveillance conditions. The objectives of this study were to evaluate treatment outcomes among TB patients, analyze factors associated with a fatal outcome and determine the proportion of deaths attributable to TB in the district of Manhiça, Southern Mozambique. METHODS: This is a retrospective observational study based on TB patients diagnosed in the period 2011-2012...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27180737/epidemiology-of-tuberculosis-and-evaluation-of-treatment-outcomes-in-the-national-tuberculosis-control-programme-river-nile-state-sudan-2011-2013
#18
W M Elmadhoun, S K Noor, S O Bushara, E O Ahmed, H Mustafa, A A Sulaiman, A O Almobarak, M H Ahmed
Tuberculosis is a major health problem in Sudan, a country that carries 11-15% of the tuberculosis burden in the Eastern Mediterranean Region. This study aimed to describe the epidemiology of tuberculosis in River Nile State and to compare treatment outcomes with WHO recommended indicators. A descriptive study was conducted on data collected from records of 1221 patients registered at tuberculosis management units over the 3 years 2011-2013. The mean age of cases was 37.7 (SD 21.5) years and 65.9% were males; 76...
April 28, 2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/27176911/ethnic-and-racial-inequalities-in-notified-cases-of-tuberculosis-in-brazil
#19
Paulo Victor de Sousa Viana, Maria Jacirema Ferreira Gonçalves, Paulo Cesar Basta
OBJECTIVE: This study analysed clinical and sociodemographic aspects and follow-up for notified cases of tuberculosis (TB) and explored inequalities in incidence rates and outcome by colour or race and the geographic macro-regions of Brazil. METHODS: This paper reports the results of a population-based descriptive epidemiological study of all notified cases of TB in Brazil during the period from 01/01/2008 to 31/12/2011. We analysed sociodemographic and clinical variables according to colour or race (white, black, Asian, mixed, and indigenous) and geographic macro-regions of the country (North, Northeast, Central-West, South, and Southeast)...
2016: PloS One
https://www.readbyqxmd.com/read/27163360/high-rates-of-treatment-success-in-pulmonary-multidrug-resistant-tuberculosis-by-individually-tailored-treatment-regimens
#20
Ioana D Olaru, Christoph Lange, Alexander Indra, Liliya Meidlinger, Steliana Huhulescu, Rudolf Rumetshofer
RATIONALE: We evaluated whether treatment outcomes for patients with multidrug-resistant and extensively drug-resistant tuberculosis can be substantially improved when sufficient resources for personalizing medical care are available. OBJECTIVES: To describe the characteristics and outcomes of patients with pulmonary multidrug-resistant tuberculosis at the Otto Wagner Hospital in Vienna, Austria. METHODS: We conducted a retrospective single-center study of patients initiated on treatment for multi-drug resistant tuberculosis between January 2003 and December 2012 at the Otto Wagner Hospital, Vienna, Austria...
August 2016: Annals of the American Thoracic Society
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