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R Parchure, V Kulkarni, R Gangakhedkar, S Swaminathan
SETTING: Little is known about outcomes of patients co-infected with human immunodeficiency virus (HIV) and tuberculosis (TB) who are treated in the private sector in India. OBJECTIVE: To describe the treatment outcomes of daily anti-tuberculosis treatment (ATT) and their determinants among HIV-TB co-infected patients treated at a private clinic in Pune, India. DESIGN: Data on adult HIV-TB co-infected patients treated with daily ATT were analysed using logistic regression and Cox model to assess risk factors for default and death...
October 2016: International Journal of Tuberculosis and Lung Disease
Aylana de Souza Belchior, Ricardo Alexandre Arcêncio, Evelyne Marie Therese Mainbourg
OBJECTIVE: To identify the socioeconomic and clinical-epidemiological factors related to tuberculosis in new cases and retreatment cases. METHOD: Comparative study with 126 patients, of which 42 were retreatment cases after default attended in a reference center, and 84 were new cases completing the first treatment and treated in Basic Health Units. The collection of primary data was through interview, and of secondary data by records of the Notifiable Diseases Information System...
July 2016: Revista da Escola de Enfermagem da U S P
Omar Salad Elmi, Habsah Hasan, Sarimah Abdullah, Mat Zuki Mat Jeab, Zilfalil Ba, Nyi Nyi Naing
BACKGROUND: Treating patients with multidrug-resistant tuberculosis (MDR-TB) strains is more complicated, complex, toxic, expensive, than treating patients with susceptible TB strains. This study aims to compare the treatment outcomes and potential factors associated between patients with MDR-TB and non MDR TB infections in peninsular Malaysia. METHODS: This study was a retrospective cohort study. Data were collected from the medical records of all registered MDR-TB patients and Non-MDR-TB patients at five TB hospitals in peninsular Malaysia from January 2010 to January 2014...
July 2016: Malaysian Journal of Medical Sciences: MJMS
Deepti Rathee, Piyush Arora, Manoj Meena, Rohit Sarin, Pitambar Chakraborty, Anand Jaiswal, Mukesh Goyal
INTRODUCTION: Tuberculosis (TB) is one of the leading causes of death and disease worldwide. Tobacco smoking has been linked as a risk factor for TB. This study was aimed to affirm the strength of association between smoking and pulmonary TB. MATERIALS AND METHODS: Pulmonary TB patients aged between 18 and 65 years were enrolled and followed-up until treatment completion. Two consecutive sputum smears were examined from each patient for the presence of acid-fast bacilli (AFB) using Ziehl-Neelsen technique...
September 2016: Lung India: Official Organ of Indian Chest Society
Tizazu Zenebe, Ermias Tefera
Evaluating the outcomes of tuberculosis treatment and understanding the specific reasons for unfavorable treatment outcome are important in evaluating the effectiveness of tuberculosis control program. A retrospective study was conducted to assess tuberculosis treatment outcomes and associated factors among smear positive pulmonary tuberculosis patients in zone-one health facilities of Afar regional state, Ethiopia. A total of 380 smear positive pulmonary tuberculosis patients' registration book recorded with complete information from Jan 2011 to Dec 2013 were analyzed...
August 20, 2016: Brazilian Journal of Infectious Diseases
A D Harries, S M Graham, M M Weismuller, Njm Claessens, S Meijnen, N J Hargreaves, C Mwansambo, P N Kazembe, F M Salaniponi
There were 22,982 cases of TB registered in Malawi in 1998, of which 2739 (11.9%) were children. Children accounted for 11.3% of all case notifications with smear-positive pulmonary TB (PTB), 21.3% with smear-negative PTB and 15.9% with extrapulmonary TB (EPTB). A significantly higher proportion of TB cases were diagnosed in central hospitals. Only 45% of children completed treatment. There were high rates of death (17%), default (13%) and unknown treatment outcomes (21%). Treatment outcomes were worse in younger children and in children with smear-negative PTB...
December 2005: Malawi Medical Journal: the Journal of Medical Association of Malawi
Adamson S Muula, Yohane Nyasulu, Henry Feluzi, Collins Magalasi
We report findings of a pilot qualitative study in which we aimed to determine management gaps among TB patients from Mozambique obtaining health care services in Malawi. The study was conducted between April and May 2002 involved twelve health workers and 4 Mozambican patients. Semi-structured questionnaires were used and responses were followed up with in-depth interviews. Several areas of management gaps were identified. These included; language barrier if patients are formally referred with documents in Portuguese; lack of follow-up system in case of patients defaulting; no structured contact-tracing possibilities and no initiation of Isoniazid prophylaxis in the case of children living in households with a sputum smear positive adult case...
June 2003: Malawi Medical Journal: the Journal of Medical Association of Malawi
Z G Dememew, D Habte, M Melese, S D Hamusse, G Nigussie, N Hiruy, B Girma, Y Kassie, Y K Haile, D Jerene, P Suarez
SETTING: Amhara and Oromia Regions, Ethiopia. OBJECTIVE: To determine trends in case notification rates (CNRs) among new tuberculosis (TB) cases and treatment outcomes of sputum smear-positive (SS+) patients based on geographic setting, sex and age categories. METHODS: We undertook a trend analysis over a 4-year period among new TB cases reported in 10 zones using a trend test, a mean comparison t-test and one-way analysis of variance. RESULTS: The average CNR per 100 000 population was 128...
September 2016: International Journal of Tuberculosis and Lung Disease
R Kaplan, J Caldwell, S Hermans, S Adriaanse, L Mtwisha, L-G Bekker, K Jennings, R Wood
SETTING: Cape Town, South Africa. OBJECTIVE: To evaluate anti-tuberculosis treatment outcomes and rate of antiretroviral therapy (ART) initiation using weekly community-based adherence support compared to daily directly observed therapy (DOT). METHODS: This was a retrospective analysis comparing two cohorts treated for tuberculosis (TB) in 70 TB clinics during 6-month periods before and after the introduction of a new adherence model comprising treatment literacy sessions during 2 weeks of DOT, followed by weekly home visits by community care workers to eligible patients managing their own treatment...
September 2016: International Journal of Tuberculosis and Lung Disease
Miraj Ahmed, Anupam Mishra, Kamal Kumar Sawlani, Veerendra Verma, Rajiv Garg, Hitendra Prakash Singh, Sunil Kumar
The Global tuberculosis control is challenged with a growing resistance to antitubercular treatment (ATT) culminating in resistant (MDR/XDR) strains; an important factor being premature withdrawal of streptomycin owing to its morbidity particularly nephrotoxicity and cochleotoxicity as guidelines for their prevention exist. An attempt is made here to address the least recognized and most debilitating vestibular toxic effects of streptomycin and defining a vestibular-protocol for its early detection and progression...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
Alberto L García-Basteiro, Durval Respeito, Orvalho J Augusto, Elisa López-Varela, Charfudin Sacoor, Victor G Sequera, Aina Casellas, Quique Bassat, Ivan Manhiça, Eusebio Macete, Frank Cobelens, Pedro L Alonso
BACKGROUND: In Mozambique, there is limited data regarding the monitoring of Tuberculosis (TB) treatment results and determinants of adverse outcomes under routine surveillance conditions. The objectives of this study were to evaluate treatment outcomes among TB patients, analyze factors associated with a fatal outcome and determine the proportion of deaths attributable to TB in the district of Manhiça, Southern Mozambique. METHODS: This is a retrospective observational study based on TB patients diagnosed in the period 2011-2012...
2016: BMC Infectious Diseases
W M Elmadhoun, S K Noor, S O Bushara, E O Ahmed, H Mustafa, A A Sulaiman, A O Almobarak, M H Ahmed
Tuberculosis is a major health problem in Sudan, a country that carries 11-15% of the tuberculosis burden in the Eastern Mediterranean Region. This study aimed to describe the epidemiology of tuberculosis in River Nile State and to compare treatment outcomes with WHO recommended indicators. A descriptive study was conducted on data collected from records of 1221 patients registered at tuberculosis management units over the 3 years 2011-2013. The mean age of cases was 37.7 (SD 21.5) years and 65.9% were males; 76...
February 2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Paulo Victor de Sousa Viana, Maria Jacirema Ferreira Gonçalves, Paulo Cesar Basta
OBJECTIVE: This study analysed clinical and sociodemographic aspects and follow-up for notified cases of tuberculosis (TB) and explored inequalities in incidence rates and outcome by colour or race and the geographic macro-regions of Brazil. METHODS: This paper reports the results of a population-based descriptive epidemiological study of all notified cases of TB in Brazil during the period from 01/01/2008 to 31/12/2011. We analysed sociodemographic and clinical variables according to colour or race (white, black, Asian, mixed, and indigenous) and geographic macro-regions of the country (North, Northeast, Central-West, South, and Southeast)...
2016: PloS One
Ioana D Olaru, Christoph Lange, Alexander Indra, Liliya Meidlinger, Steliana Huhulescu, Rudolf Rumetshofer
RATIONALE: We evaluated whether treatment outcomes for patients with multidrug-resistant and extensively drug-resistant tuberculosis can be substantially improved when sufficient resources for personalizing medical care are available. OBJECTIVES: To describe the characteristics and outcomes of patients with pulmonary multidrug-resistant tuberculosis at the Otto Wagner Hospital in Vienna, Austria. METHODS: We conducted a retrospective single-center study of patients initiated on treatment for multi-drug resistant tuberculosis between January 2003 and December 2012 at the Otto Wagner Hospital, Vienna, Austria...
August 2016: Annals of the American Thoracic Society
Muhammad Amir Khan, Muhammad Arif Munir, Shirin Anil, Maqsood Ahmad, John Walley, Ejaz Qadeer, Karam Shah, Nida Khan, Athar Nazir
OBJECTIVE: To develop and evaluate a more structured process for effective tuberculosis control monitoring. METHODS: The quasi-experimental exploratory study was conducted from April 2007 to January 2008 in the Punjab province of Pakistan. Eight intervention districts were compared with eight control districts. Intervention consisted of managers using performance monitoring guidelines and tools for monitoring meetings at the facility and district levels. Proportion of tuberculosis suspects among outpatients, registered confirmed cases and patients' default rate were monitored...
April 2016: JPMA. the Journal of the Pakistan Medical Association
Loukia Aketi, Zacharie Kashongwe, Christian Kinsiona, Serge Bisuta Fueza, Jack Kokolomami, Grace Bolie, Paul Lumbala, Joseph Shiku Diayisu
Childhood tuberculosis (TB) is a diagnostic challenge in developing countries, and patient outcome can be influenced by certain factors. We report the disease course, clinical profile and factors associated with treatment outcome in a tertiary facility of Kinshasa. Documentary and analytical studies were conducted using clinical and exploratory data for children aged up to 15 years who were admitted to the University Clinics of Kinshasa for TB. Data are presented as frequencies and averages, and binary and logistic regression analyses were performed...
2016: PloS One
Gebreslassie Gebremariam, Getachew Asmamaw, Muktar Hussen, Mengistu Z Hailemariam, Demissie Asegu, Ayalew Astatkie, Anteneh G Amsalu
BACKGROUND: Despite implementation of different strategies, the burden and mortality of human immunodeficiency virus (HIV)-associated tuberculosis (TB) remains a challenge in Ethiopia. The aim of this study was to assess the impact of HIV status on treatment outcome of tuberculosis patients registered at Arsi Negele Health Center, Southern Ethiopia. METHODS: A six-year retrospective data (from September 2008 to August 2014) of tuberculosis patients (n = 1649) registered at the directly observed therapy short-course (DOTS) clinic of Arsi Negele Health Center was reviewed...
2016: PloS One
Siva Balaji Reddy Satti, Nagaraj Kondagunta
BACKGROUND: The therapeutic regimens as recommended by the Revised National TB Control Programme (RNTCP) have been shown to be highly effective for both preventing and treating tuberculosis, but poor adherence to medication is a major barrier to its global control. AIM AND OBJECTIVES: The study was conducted to assess the influence of patient related factors for DOTS Treatment Default among HIV-TB Co-infected cases. SETTING AND DESIGN: This was a case control study conducted in Nalgond, Telangana...
April 2016: Indian Journal of Community Medicine
E J Rakotonirina, L Ravaoarisoa, A Raherinandrasana, B Vololonarivelo, M Rakotonjanahary, J D M Rakotomanga, J Macq
INTRODUCTION: This study assesses the nationwide applicability of results from a study in the tuberculosis (TB) diagnostic and treatment centers (DTCs) in a sample of six districts in Madagascar, which identified adaptations of national guidelines and local initiatives that might explain the effectiveness of individual DTCs in improving adherence to TB treatment and thus reducing treatment default. OBJECTIVE: To assess, at a national level, the importance of these adaptations/initiatives for TB treatment adherence...
January 2016: Médecine et Santé Tropicales
Anne E Asuquo, Benjamin D Thumamo Pokam, Emmanuel Ibeneme, Esu Ekpereonne, Valerie Obot, P N Asuquo
BACKGROUND: Tuberculosis (TB) infection and spread are preventable, and TB disease is curable depending on individual and community knowledge of causes of the disease, mode of prevention and cure. An earlier educational intervention carried out in Akwa Ibom State (AKS) of Nigeria in 2006 created awareness of the disease and improved utilization of orthodox medical facilities of residents in 34 communities who had symptoms of TB. OBJECTIVE: The overall aim of this program is to reduce the burden of TB disease in 18 communities of AKS through educational intervention, TB case detection and integration into the State National Tuberculosis and Leprosy Control Programme (NTBLCP), as well as build laboratory capacity to improve TB case detection and control...
June 2015: International Journal of Mycobacteriology
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