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https://www.readbyqxmd.com/read/29209440/efficacy-of-fenugreek-based-bionanocomposite-on-renal-dysfunction-and-endogenous-intoxication-in-high-calorie-diet-induced-obesity-rat-model-comparative-study
#1
Victoria V Konopelniuk, Ievgenii I Goloborodko, Tetyana V Ishchuk, Tetyana B Synelnyk, Ludmila I Ostapchenko, Mykola Ya Spivak, Rostyslav V Bubnov
Background: Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat)...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29203632/uric-acid-is-a-strong-risk-marker-for-developing-hypertension-from-prehypertension-a-5-year-japanese-cohort-study
#2
Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid levels...
December 4, 2017: Hypertension
https://www.readbyqxmd.com/read/29199508/wrist-inflammation-a-retrospective-comparison-between-septic-and-non-septic-arthritis
#3
Gavrielle Kang, Mabel Q H Leow, Shian-Chao Tay
This study aims to identify differences in demographics, clinical and laboratory data between wrist septic arthritis and non-septic arthritis in patients admitted for wrist inflammation. A retrospective review of inpatients from May 2012 to April 2015 was conducted. Seventy-seven patients were included. Non-septic arthritis patients were more likely to have chronic kidney disease, pre-existing gout, or both. All septic arthritis patients had normal serum uric acid levels, and two or more raised inflammatory markers (white cell count, C-reactive protein, erythrocyte sedimentation rate)...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29165620/comparative-effectiveness-of-allopurinol-febuxostat-and-benzbromarone-on-renal-function-in-chronic-kidney-disease-patients-with-hyperuricemia-a-13-year-inception-cohort-study
#4
Hsu-Wen Chou, Hsien-Tsai Chiu, Ching-Wei Tsai, I-Wen Ting, Hung-Chieh Yeh, Han-Chun Huang, Chin-Chi Kuo
Background: Direct comparisons of the effectiveness of allopurinol with that of other urate-lowering agents in chronic kidney disease (CKD) populations, as well as guideline recommendations for clinical practice, are lacking. Methods: We constructed a pharmacoepidemiology cohort study by including patients from Taiwan's long-term integrated CKD care program to compare the effectiveness among allopurinol, febuxostat and benzbromarone in reducing the risk of progression to dialysis...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29154722/association-of-kidney-function-and-waist-circumference-with-uric-acid-levels-in-south-africans
#5
Nomandla Daphne Madala, Thozama Dubula, Alain Guy Honoré Assounga, Saraladevi Naicker
BACKGROUND: Recent evidence that hyperuricemia is associated with incident chronic kidney disease (CKD) provides a potential therapeutic target for CKD that has not been explored in Africans. With hyperuricemia and gout increasing globally, we sought to determine their prevalence in South Africans with varying kidney function levels. METHODS: This was a cross-sectional study of ambulatory adult patients presenting at a General Internal Medicine Outpatients Clinic between September 2012 and March 2014...
November 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29140472/uric-acid-predicts-adverse-outcomes-in-chronic-kidney-disease-a-novel-insight-from-trajectory-analyses
#6
Ching-Wei Tsai, Hsien-Tsai Chiu, Han-Chun Huang, I-Wen Ting, Hung-Chieh Yeh, Chin-Chi Kuo
Background: Very little is known about longitudinal trajectories of serum uric acid (SUA) over the course of chronic kidney disease (CKD). We aimed to determine whether longitudinal SUA trajectories are associated with the risk of end-stage renal disease (ESRD) and all-cause mortality among CKD patients. Methods: We conducted a prospective cohort study from a 13-year multidisciplinary pre-ESRD care registry. The final study population consisted of 5090 CKD patients aged 20-90 years between 2003 and 2015...
November 10, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29137059/adherence-to-gout-management-recommendations-of-chinese-patients
#7
Feng Sheng, Weigang Fang, Bingqing Zhang, Yue Sha, Xuejun Zeng
Though efficacious and affordable treatments for gout are widely available, gout is still not well controlled in many countries of the world including China.To investigate patient adherence to gout management recommendations and potential barriers in Chinese male gout patients, a survey was carried out by telephone interview in male patients registered in the gout clinic at Peking Union Medical College Hospital. Adherence to dietary and medication recommendations was measured by a food frequency questionnaire and proportion of cumulative time adherent to chemical urate-lowering therapy (ULT), respectively...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136619/risk-factor-analysis-for-aki-including-laboratory-indicators-a-nationwide-multicenter-study-of-hospitalized-patients
#8
Sasa Nie, Zhe Feng, Li Tang, Xiaolong Wang, Yani He, Jingai Fang, Suhua Li, Yibin Yang, Huijuan Mao, Jundong Jiao, Wenhu Liu, Ning Cao, Wenge Wang, Jifeng Sun, Fengmin Shao, Wenge Li, Qiang He, Hongli Jiang, Hongli Lin, Ping Fu, Xinzhou Zhang, Yinghong Liu, Yonggui Wu, ChunSheng Xi, Meng Liang, Zhijie Qu, Jun Zhu, Guangli Wu, Yali Zheng, Yu Na, Ying Li, Wei Li, Guangyan Cai, Xiangmei Chen
BACKGROUND/AIMS: Risk factor studies for acute kidney injury (AKI) in China are lacking, especially those regarding non-traditional risk factors, such as laboratory indicators. METHODS: All adult patients admitted to 38 tertiary and 22 secondary hospitals in China in any one month between July and December 2014 were surveyed. AKI patients were screened according to the Kidney Disease: Improving Global Outcomes' definition of AKI. Logistic regression was used to analyze the risk factors for AKI, and Cox regression was used to analyze the risk of in-hospital mortality for AKI patients; additionally, a propensity score analysis was used to reconfirm the risk factors among laboratory indicators for mortality...
October 24, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29132945/uric-acid-and-the-risks-of-kidney-failure-and-death-in-individuals-with-ckd
#9
Anand Srivastava, Arnaud D Kaze, Ciaran J McMullan, Tamara Isakova, Sushrut S Waikar
BACKGROUND: Serum uric acid concentrations increase in chronic kidney disease (CKD) and may lead to tubular injury, endothelial dysfunction, oxidative stress, and intrarenal inflammation. Whether uric acid concentrations are associated with kidney failure and death in CKD is unknown. STUDY DESIGN: Prospective observational cohort study. SETTINGS & PARTICIPANTS: 3,885 individuals with CKD stages 2 to 4 enrolled in the Chronic Renal Insufficiency Cohort (CRIC) between June 2003 and September 2008 and followed up through March 2013...
November 10, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29124443/identification-of-cdc42bpg-as-a-novel-susceptibility-locus-for-hyperuricemia-in-a-japanese-population
#10
Yoshiki Yasukochi, Jun Sakuma, Ichiro Takeuchi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Yoshiji Yamada
Chronic kidney disease and hyperuricemia are serious global health problems. Recent genome-wide association studies have identified various genetic variants related to these disorders. However, most studies have been conducted in a cross-sectional manner. To identify novel susceptibility loci for chronic kidney disease or hyperuricemia, we performed longitudinal exome-wide association studies (EWASs), using ~ 244,000 genetic variants and clinical data of Japanese individuals who had undergone annual health checkups for several years...
November 9, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29119539/higher-prevalence-of-unrecognized-kidney-disease-at-high-altitude
#11
Abdias Hurtado-Arestegui, Raul Plata-Cornejo, Arturo Cornejo, Guiliana Mas, Luz Carbajal, Shailendra Sharma, Erik R Swenson, Richard J Johnson, Jackelina Pando
BACKGROUND: High altitude renal syndrome has been described in populations with excessive erythrocytosis. We evaluated whether high altitude (HA) dwellers might be at increased risk for kidney disease. METHODS: We performed a cross-sectional study to investigate differences in prevalence of kidney function and metabolic syndrome in healthy subjects living at HA vs. sea level (SL) without any known history of hypertension, diabetes or chronic kidney disease. RESULTS: We examined 293 subjects, aged 40 to 60 years: 125 SL (154 m) and 168 HA (3640 m) dwellers...
November 8, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29099466/association-of-proton-pump-inhibitor-use-with-serum-biomarkers-of-inflammation-insulin-resistance-cardiovascular-risk-and-renal-function
#12
Gregory L Austin, Jennifer R Weiskopf, Jennifer L Czwornog
BACKGROUND AND GOALS: Proton pump inhibitor (PPI) use has been associated with cardiovascular disease, chronic kidney disease, and dementia. Prior studies did not account for key confounders and little is known about the association of PPIs with serum biomarkers of inflammation, insulin resistance, cardiovascular risk, and renal function. Our aims were to investigate differences in these biomarkers between PPI users and nonusers. METHODS: Our data are from the National Health and Nutrition Examination Survey (NHANES), a complex cross-sectional multistage probability sample of the US civilian population...
November 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29095953/effects-of-uric-acid-lowering-therapy-in-patients-with-chronic-kidney-disease-a-meta-analysis
#13
Xiaole Su, Boyang Xu, Bingjuan Yan, Xi Qiao, Lihua Wang
BACKGROUND AND OBJECTIVES: The effects of uric acid-lowering therapy in patients with chronic kidney disease (CKD) remain uncertain. Therefore, we undertook a systematic review and meta-analysis to investigate the effects of uric acid-lowering agents on major clinical outcomes of CKD. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: According to the pre-specified protocol that was registered with PROSPERO (No. CRD42016038030), we searched systematically in MEDLINE, EMBASE, and the Cochrane Library for trials up to February 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29094330/the-association-between-elevated-serum-uric-acid-level-and-an-increased-risk-of-renal-function-decline-in-a-health-checkup-cohort-in-china
#14
Xia Cao, Liuxin Wu, Zhiheng Chen
PURPOSE: To investigate whether an elevated serum uric acid (SUA) level is an independent risk factor for rapid decline in renal function or new-onset chronic kidney disease (CKD) in a Chinese health checkup population. METHODS: A cohort study of 6495 Chinese individuals who underwent health checkups with normal estimated glomerular filtration rate (eGFR) at baseline was carried out from May 2011 to April 2016. Examinations included a questionnaire, physical measurements, and blood sampling...
November 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29084343/uric-acid-lowering-therapies-for-preventing-or-delaying-the-progression-of-chronic-kidney-disease
#15
REVIEW
Anna L Sampson, Richard F Singer, Giles D Walters
BACKGROUND: Non-randomised data have shown a link between hyperuricaemia and the progression or development of chronic kidney disease (CKD). If this is correct, urate lowering therapy might form an important part of chronic kidney disease care, reducing risks for cardiovascular outcomes and end-stage kidney disease. OBJECTIVES: This review aims to study the benefits and harms of uric acid lowering therapy on the progression of CKD and other cardiovascular endpoints...
October 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29071435/the-effect-of-xanthine-oxidase-inhibitors-on-blood-pressure-and-renal-function
#16
REVIEW
Marilisa Bove, Arrigo F G Cicero, Claudio Borghi
Several epidemiological studies have demonstrated the existence of a correlation between high serum uric acid (SUA) levels, hypertension, and chronic kidney disease (CKD). Xantine oxidase inhibitors (XOI) are the most powerful uric acid lowering drugs, with presumed beneficial effects on cardiovascular and renal system. The multifactorial mechanism linking hyperuricemia with cardiovascular and renal diseases involves both the SUA level and the xanthine oxidase (XO) activity. In this context, the clinical research has been recently focused at assessing the efficacy of urate-lowering drugs active on XO in patients with abnormal blood pressure values and renal dysfunction...
October 25, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29033310/relation-of-elevated-serum-uric-acid-levels-to-first-degree-heart-block-and-other-cardiac-conduction-defects-in-hospitalized-patients-with-type-2-diabetes
#17
Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Giovanni Morani, Stefano Bonapace, Clementina Dugo, Giacomo Zoppini, Enzo Bonora, Giovanni Targher
AIMS: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM. METHODS: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014...
December 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29032376/impact-of-uric-acid-levels-on-kidney-disease-progression
#18
Hernan Rincon-Choles, Stacey E Jolly, Susana Arrigain, Victoria Konig, Jesse D Schold, Georges Nakhoul, Sankar D Navaneethan, Joseph V Nally, Michael B Rothberg
BACKGROUND: Hyperuricemia is associated with the progression of chronic kidney disease (CKD), but it is not known whether the relationship is causal. We examined the association of hyperuricemia and uric acid lowering therapy (UALT) with progression of CKD in patients with CKD 3 and 4 in the Cleveland Clinic CKD registry. METHODS: We included 1,676 patients with CKD stages 3 and 4 from Ohio, who had measured their uric acid (UA) levels a year prior to the recording of the second eGFR <60 mL/min/1...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29029600/clinical-features-and-ckd-related-quality-of-life-in-patients-with-ckd-g3a-and-ckd-g3b-in-china-results-from-the-chinese-cohort-study-of-chronic-kidney-disease-c-stride
#19
Zhangzhe Peng, Jinwei Wang, Qiongjing Yuan, Xiangcheng Xiao, Hui Xu, Yanyun Xie, Wei Wang, Ling Huang, Yong Zhong, Xiang Ao, Luxia Zhang, Minghui Zhao, Lijian Tao, Qiaoling Zhou
BACKGROUND: This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chinese patients with CKD. METHODS: Participants with stage 3 CKD (18-74 years of age) were recruited at 39 clinical centers located at 28 cities in 22 provinces of China. The sociodemographic status, medical history, anthropometric measurements, and lifestyle behaviors were documented at entry, and blood and urine samples were collected...
October 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29024864/association-between-serum-uric-acid-level-and-renal-arteriolar-hyalinization-in-individuals-without-chronic-kidney-disease
#20
Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Naoki Haruyama, Yasuhiro Okabe, Masafumi Nakamura, Kazuhiko Tsuruya, Takanari Kitazono
BACKGROUND AND AIMS: Recent studies have reported an association between serum uric acid (SUA) and renal arteriolar changes in patients with chronic kidney disease (CKD). However, the association in individuals without CKD remains unclear. In this study, we investigated the relationship between SUA and renal arteriolar lesions in individuals without CKD from our living kidney donor cohort. METHODS: Between January 2006 and May 2016, 393 living kidney donors underwent "time-zero" biopsy at Kyushu University Hospital...
November 2017: Atherosclerosis
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