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https://www.readbyqxmd.com/read/28445768/polymer-free-electrospun-nanofibers-from-sulfobutyl-ether7-beta-cyclodextrin-sbe7-%C3%AE-cd-inclusion-complex-with-sulfisoxazole-fast-dissolving-and-enhanced-water-solubility-of-sulfisoxazole
#1
Zehra Irem Yildiz, Asli Celebioglu, Tamer Uyar
In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD, Captisol(®)), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-β-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web...
April 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28445765/in-line-monitoring-and-optimization-of-powder-flow-in-a-simulated-continuous-process-using-transmission-near-infrared-spectroscopy
#2
Md Anik Alam, Zhenqi Shi, James K Drennen, Carl A Anderson
In-line monitoring of continuous powder flow is an integral part of the continuous manufacturing process of solid oral dosage forms in the pharmaceutical industry. Specifically, monitoring downstream from loss-in-weight (LIW) feeders and/or continuous mixers provides important data about the state of the process. Such measurements support control of the process and thereby enhance product quality. Near Infrared Spectroscopy (NIRS) is a potential PAT tool to monitor the homogeneity of a continuous powder flow stream in pharmaceutical manufacturing...
April 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28445444/pharmaceutical-equivalence-of-clarithromycin-oral-dosage-forms-marketed-in-nairobi-county-kenya
#3
Rebecca O Manani, Kennedy O Abuga, Hezekiah K Chepkwony
Clarithromycin is a broad-spectrum semi-synthetic macrolide indicated for treatment of pneumonias, Helicobacter pylori, and chlamydial and skin infections. The object of this study was to evaluate the pharmaceutical equivalence of 14 generic clarithromycin products marketed in Nairobi County, Kenya, to the innovator products, using in vitro dissolution profiles and similarity factors (f₂). Further, dissolution profiles of four innovator formulations manufactured in different sites were compared. Fourteen clarithromycin tablets/capsules and four suspensions were subjected to assay and comparative dissolution runs at pH 1...
April 26, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28445056/superior-plasticity-and-tabletability-of-theophylline-monohydrate
#4
Shao-Yu Chang, Changquan Calvin Sun
A theophylline monohydrate (THm) powder, with particle size and shape substantially similar to a theophylline anhydrate powder, was prepared by vapor mediated phase conversion. The elimination of possible contributions by particle size and shape to tableting properties made it possible to unambiguously identify the role of bonding area and bonding strength on powder tableting performance. It was also shown that accurate true density is essential for correct analysis and understanding of tableting behavior of THm...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28444716/the-relative-bioavailability-of-ibuprofen-after-administration-with-a-novel-soft-chewable-drug-formulation
#5
Magnus N Hattrem, Morten J Dille, Tore Seternes, Thorfinn Ege, Kurt I Draget
The first aim of the present study was to evaluate the bioavailability of ibuprofen dispersed in a novel soft chewable formulation compared with a traditional ibuprofen tablet; its second was to map the quality of taste masking and patient product satisfaction. In a phase 1, single-center, open-label, randomized, crossover study, healthy subjects received a soft-chew formulation or a hard tablet (reference), both containing 100 mg ibuprofen. Serial blood samples were collected over 24 hours to assess ibuprofen bioavailability...
April 25, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28443690/vitrified-warmed-blastocyst-transfer-on-the-5th-or-7th-day-of-progesterone-supplementation-in-an-artificial-cycle-a-randomised-controlled-trial
#6
A van de Vijver, P Drakopoulos, N P Polyzos, L Van Landuyt, S Mackens, S Santos-Ribeiro, V Vloeberghs, H Tournaye, C Blockeel
Prospective studies comparing different durations of progesterone supplementation before transfer of vitrified-warmed blastocysts in an artificial cycle are lacking. However, in oocyte donation programmes, the sporadic available evidence demonstrates considerable differences in clinical pregnancy rates according to the duration of progesterone administration. This randomised controlled trial (RCT), included 303 patients undergoing a frozen-thawed embryo transfer (FET) of one or two vitrified-warmed blastocyst(s) in an artificial cycle...
April 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28443252/open-label-phase-ii-clinical-trial-in-75-patients-with-advanced-hepatocellular-carcinoma-receiving-daily-dose-of-tableted-liver-cancer-vaccine-hepcortespenlisimut-l
#7
Marina G Tarakanovskaya, Jigjidsuren Chinburen, Purev Batchuluun, Chogsom Munkhzaya, Genden Purevsuren, Dorjiin Dandii, Tsogkhuu Hulan, Dandii Oyungerel, Galyna A Kutsyna, Alan A Reid, Vika Borisova, Allen I Bain, Vichai Jirathitikal, Aldar S Bourinbaiar
BACKGROUND: An increasing number of studies is now devoted to immunotherapy of cancer. We evaluated the clinical benefit of hepcortespenlisimut-L (Hepko-V5 [formerly known as V5])-an oral therapeutic vaccine designated by the United States Food and Drug Administration (FDA) as an orphan drug for treatment of hepatocellular carcinoma (HCC). V5 was initially developed by us in 2002 to treat hepatitis B or C viral infections and liver cirrhosis. METHODS: The outcome of open-label Phase II trial of daily dose of V5 pill was analyzed retrospectively...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28443047/synchrony-in-joint-action-is-directed-by-each-participant-s-motor-control-system
#8
Lior Noy, Netta Weiser, Jason Friedman
In this work, we ask how the probability of achieving synchrony in joint action is affected by the choice of motion parameters of each individual. We use the mirror game paradigm to study how changes in leader's motion parameters, specifically frequency and peak velocity, affect the probability of entering the state of co-confidence (CC) motion: a dyadic state of synchronized, smooth and co-predictive motions. In order to systematically study this question, we used a one-person version of the mirror game, where the participant mirrored piece-wise rhythmic movements produced by a computer on a graphics tablet...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28442892/bioequivalence-study-of-a-new-sildenafil-100-mg-orodispersible-film-compared-to-the-conventional-film-coated-100-mg-tablet-administered-to-healthy-male-volunteers
#9
Milko Radicioni, Chiara Castiglioni, Andrea Giori, Irma Cupone, Valeria Frangione, Stefano Rovati
A new orodispersible film formulation of the phosphodiesterase type 5 inhibitor, sildenafil, has been developed to examine the advantages of an orally disintegrating film formulation and provide an alternative to the current marketed products for the treatment of erectile dysfunction. The pharmacokinetics of the sildenafil 100 mg orodispersible film (IBSA) was compared to that of the conventional marketed 100 mg film-coated tablet (Viagra(®)) after single-dose administration to 53 healthy male volunteers (aged 18-51 years) in a randomized, open, two-way crossover bioequivalence study...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28442890/justification-of-disintegration-testing-beyond-current-fda-criteria-using-in-vitro-and-in-silico-models
#10
Lukas Uebbing, Lukas Klumpp, Gregory K Webster, Raimar Löbenberg
Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration testing, the mentioned criteria are not globally accepted. This study provides scientific justification for using disintegration testing rather than dissolution testing as a quality control method for certain immediate release (IR) formulations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28442456/the-malaria-system-microapp-a-new-mobile-device-based-tool-for-malaria-diagnosis
#11
Allisson Dantas Oliveira, Clara Prats, Mateu Espasa, Francesc Zarzuela Serrat, Cristina Montañola Sales, Aroa Silgado, Daniel Lopez Codina, Mercia Eliane Arruda, Jordi Gomez I Prat, Jones Albuquerque
BACKGROUND: Malaria is a public health problem that affects remote areas worldwide. Climate change has contributed to the problem by allowing for the survival of Anopheles in previously uninhabited areas. As such, several groups have made developing news systems for the automated diagnosis of malaria a priority. OBJECTIVE: The objective of this study was to develop a new, automated, mobile device-based diagnostic system for malaria. The system uses Giemsa-stained peripheral blood samples combined with light microscopy to identify the Plasmodium falciparum species in the ring stage of development...
April 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28441699/folic-acid-therapy-reduces-the-risk-of-mortality-associated-with-heavy-proteinuria-among-hypertensive-patients
#12
Youbao Li, Xianhui Qin, Lian Luo, Binyan Wang, Yong Huo, Fan Fan Hou, Xin Xu
OBJECTIVE: We aimed to evaluate whether proteinuria and estimated glomerular filtration rate (eGFR) levels can modify the efficacy of folic acid therapy on the risk of all-cause mortality among hypertensive patients in the China Stroke Primary Prevention Trial, a randomized, double-blind, and controlled trial. METHODS: A total of 20 702 hypertensive patients without a history of major cardiovascular diseases were randomly assigned to a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28439488/randomized-double-blind-placebo-controlled-parallel-group-study-of-the-effect-of-lactobacillus-paracasei-k71-intake-on-salivary-release-of-secretory-immunoglobulin-a
#13
Yuhi Saito, Mikio Fujii, Toshiyuki Watanabe, Kentaro Maruyama, Yasuyuki Kowatari, Hiromaru Ogata, Takehisa Kumagai
Lactobacillus paracasei K71 was shown to be effective in alleviating the severity of atopic dermatitis in a randomized controlled trial, and a preliminary open-label trial suggested that strain K71 intake enhanced secretory immunoglobulin A (sIgA) release in the saliva. This study investigated the effect of K71 on sIgA release in a randomized, double-blind, placebo-controlled, parallel-group trial. The trial included 62 Japanese subjects aged 20-64 years with relatively low rates of salivary sIgA release. Subjects (n=31 in each group) were randomly given a tablet containing 100 mg (approximately 2 × 10(11) bacteria) of K71 or a placebo tablet daily for 12 weeks...
2017: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/28438334/understanding-patterns-of-injury-in-kenya-analysis-of-a-trauma-registry-data-from-a-national-referral-hospital
#14
Isaac M Botchey, Yuen Wai Hung, Abdulgafoor M Bachani, Hassan Saidi, Fatima Paruk, Adnan A Hyder
BACKGROUND: Injuries contribute to a substantial proportion of the burden of disease in Kenya. Trauma registries can be a very useful source of data to understand patterns of injuries and serve to provide information about potential improvements in the care of injured patients. In Kenya, health facility-based injury data has been largely administrative. Our aim was to develop and implement a prospective trauma registry at the largest trauma hospital in Kenya, the Kenyatta National Hospital, and to understand the nature of injuries presenting to the hospital, their treatment and care, and their outcomes...
April 21, 2017: Surgery
https://www.readbyqxmd.com/read/28438257/pharmacokinetics-and-relative-bioavailability-of-two-allopurinol-tablets-in-healthy-chinese-volunteers%C3%A2
#15
Zhen-Yan Hou, Hua-Lin Cai, Yang Deng, Zhi-Hua Li, Si-Si Cao, Ying Chen, Yao Li, Miao Yan, Bi-Kui Zhang
OBJECTIVE: To evaluate the pharmacokinetics and relative bioavailability of two allopurinol tablets in healthy Chinese volunteers. METHODS: A single-center, randomized, cross-over, two-period study design was conducted in healthy male subjects who were identified as not carrying the HLA-B*58:01 allele. Under fasting conditions, a single oral dose of 300 mg test or reference tablets was given with a 1-week washout period. The blood samples were collected for up to 12 hours after the administration and the plasma concentrations of allopurinol were determined by high performance liquid chromatography...
April 25, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28438255/a-strategy-based-on-patient-preference-improves-the-adherence-and-outcomes-of-phosphate-binders-in-hemodialysis%C3%A2
#16
M Dolores Arenas Jiménez, Eduardo Parra Moncasi, Fernando Álvarez-Ude Cotera
PURPOSE: Phosphate binders (PB) have to be taken with food, their interference with an individual's lifestyle and social habits influences treatment adherence. Several PBs are available, and patient preferences should not be ignored when prescribing. The purpose was to know the extent of intentional and unintentional nonadherence to PB in hemodialysis (HD) patients, and to evaluate the long-term results (adherence, serum phosphate levels, and cost) of a strategy of prescription of PB that takes into account patient preferences...
April 25, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28438145/insights-into-the-availability-and-distribution-of-oral-artemisinin-monotherapy-in-myanmar-evidence-from-a-nationally-representative-outlet-survey
#17
Si Thu Thein, Hnin Su Su Khin, Aung Thi
BACKGROUND: The containment of artemisinin resistance in Myanmar, historically an important probable origin and route of anti-malarial resistance to the India sub-continent and beyond, is crucial to global malaria control and elimination. This paper describes what is currently known about the sale and distribution of oral artemisinin monotherapy (AMT) across Myanmar, where this medicine is commonly found. METHODS: A nationally representative 2015 outlet survey was conducted in the private sector, and among community health workers across four geographical domains...
April 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28438131/tablets-at-the-bedside-ipad-based-visual-field-test-used-in-the-diagnosis-of-intrasellar-haemangiopericytoma-a-case-report
#18
Nisha Nesaratnam, Peter B M Thomas, Ramez Kirollos, Algis J Vingrys, George Y X Kong, Keith R Martin
BACKGROUND: In the assessment of a pituitary mass, objective visual field testing represents a valuable means of evaluating mass effect, and thus in deciding whether surgical management is warranted. CASE PRESENTATION: In this vignette, we describe a 73 year-old lady who presented with a three-week history of frontal headache, and 'blurriness' in the left side of her vision, due to a WHO grade III anaplastic haemangiopericytoma compressing the optic chiasm. We report how timely investigations, including an iPad-based visual field test (Melbourne Rapid Field, (MRF)) conducted at the bedside aided swift and appropriate management of the patient...
April 24, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28435483/cross-sectional-study-of-risky-substance-use-by-injured-emergency-department-patients
#19
Valerie Strezsak, Janette Baird, Christina S Lee, Michael J Mello
INTRODUCTION: Survey data regarding the prevalence of risky substance use in the emergency department (ED) is not consistent. The objective of this study was to identify the prevalence of risky substance use among injured ED patients based on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST v3.0). A secondary objective was to report on the feasibility of administering the ASSIST to this population, based on the time to conduct screening. METHODS: This cross-sectional study used screening data from a randomized controlled trial...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28435232/self-reported-adherence-and-associated-factors-to-isoniazid-preventive-therapy-for-latent-tuberculosis-among-people-living-with-hiv-aids-at-health-centers-in-gondar-town-north-west-ethiopia
#20
Asnakew Achaw Ayele, Seyfe Asrade Atnafie, Demis Driba Balcha, Asegedech Tsegaw Weredekal, Birhanu Alemayehu Woldegiorgis, Mulgeta Melaku Wotte, Begashaw Melaku Gebresillasie
PURPOSE: This study aimed to assess self-reported adherence and associated factors to isoniazid preventive therapy (IPT) for latent tuberculosis among people living with HIV/AIDS (PLWHA) at health centers in Gondar town, North West Ethiopia. PATIENTS AND METHODS: An institution-based prospective cross-sectional study was conducted from March 10 to June 11, 2016. A total of 154 eligible participants were included in the study, using the simple random sampling method, from the available four health centers and one teaching referral hospital that provided antiretroviral therapy (ART) for HIV/AIDS patients...
2017: Patient Preference and Adherence
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