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Luca Loprete, Chiara Leuratti, Valeria Frangione, Milko Radicioni
BACKGROUND: Sildenafil was the first selective drug available on the market as oral therapy for erectile dysfunction (ED). A novel sildenafil orodispersible film (ODF) for ED treatment, containing sildenafil citrate, has recently been marketed. OBJECTIVES: Study objective was to investigate sildenafil bioavailability of the novel ODF formulation after sublingual and supralingual administration. METHODS: In this randomised, two-way cross-over study, 12 healthy male volunteers received a single 50 mg sildenafil dose by the sublingual and supralingual administration routes...
June 16, 2018: Clinical Drug Investigation
Bakht Ali, Nighat Nisar, Faryal Nawab
Background: Human immunodeficiency virus (HIV) is fifth leading cause of mortality and disability among infectious diseases worldwide. HIV burden is increasing annually and compliance with antiretroviral therapy (ART) is low among intravenous drug users, especially in developing countries. Aim: To determine the adherence level to ART among HIV-positive intravenous drug users in Karachi Pakistan. Methods: A cross-sectional study was conducted in 2015...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Annemiek Visser, Judith B Prins, Lisette Jansen, Sandra A Radema, Margrethe S Schlooz, Thijs van Dalen, Hanneke W M van Laarhoven
OBJECTIVE: Group medical consultations (GMCs) provide individual medical visits in the presence of ≤7 peer-patients. In the follow-up of breast cancer, we evaluated the efficacy of a new type of blended care My-GMC, a GMC combined with a tablet-based online app, consisting of three online support group sessions (SGS) and additional information. METHODS: This randomized controlled trial compared the effect of My-GMC (n = 59) with one individual medical visit (n = 50) (care as usual)...
June 12, 2018: Breast: Official Journal of the European Society of Mastology
Simeone Zomer, Jun Zhang, Sameer Talwar, Sayantan Chattoraj, Christopher Hewitt
The pharmaceutical industry is undergoing a significant change in product development and manufacturing strategies with the progressive shift from batch to continuous processes. These typically feature vast volumes of data generated by the numerous sensors connected to several unit operations running over the period of several hours or even days and that demand the application of increasingly efficient tools for process understanding, monitoring and control. This paper describes the use of multivariate statistical process modeling by means of chemometric methods to monitor the continuous wet granulation tableting process for a drug product currently under development...
June 12, 2018: International Journal of Pharmaceutics
Alessandro Di Cerbo, Tommaso Iannitti, Gianandrea Guidetti, Sara Centenaro, Sergio Canello, Raffaella Cocco
Chronic kidney disease is characterized by structural and/or functional impairment of one or both kidneys persisting for more than 3 months. In cats, chronic kidney disease can frequently occur in animals aged over 9 years with an incidence of approximately 10%. Thirty-four client-owned, neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines were randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) for 90 days...
June 2018: Physiological Reports
Brian M Ilfeld, Rodney A Gabriel, Engy T Said, Amanda M Monahan, Jacklynn F Sztain, Wendy B Abramson, Bahareh Khatibi, John J Finneran, Pia T Jaeger, Alexandra K Schwartz, Sonya S Ahmed
BACKGROUND AND OBJECTIVES: Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain the day following knee surgery. However, it remains unknown if this analgesic technique may be used in ambulatory subjects following foot procedures beginning within the recovery room immediately following surgery, and with only short series of patients reported to date, the only available data are derived from strictly observational studies...
June 13, 2018: Regional Anesthesia and Pain Medicine
Jun Zhang, YongGang Luo, ZhenFeng Zhu, GuiWen Feng, Zhi Sun, XiaoJian Zhang
BACKGROUND: The aim of this study was to investigate and compare the pharmacokinetic (PK) characteristics of mycophenolate mofetil (MMF) capsule and MMF dispersible tablet by detecting the active metabolite of mycophenolic acid (MPA) in Chinese kidney transplant recipients. METHODS: In the prospective, randomized, open-label study, the renal transplant patients were given a multiple-dose of either MMF capsule or MMF dispersible tablet combination with tacrolimus (Tac)...
June 12, 2018: Therapeutic Drug Monitoring
Yi Li, Carl A Anderson, James K Drennen, Christian Airiau, Benoit Igne
In-line Process Analytical Technology sensors are the key elements to enable continuous manufacturing. They facilitate real-time monitoring of critical quality attributes of both intermediate materials and finished products. The aim of this study was to demonstrate method development and validation for in-line and off-line calibration strategies to determine the blend content during tablet compression via Raman spectroscopy. An in-line principal component regression model was developed from Raman spectra collected in the feed frame...
June 15, 2018: Analytical Chemistry
Antonis Kattamis, Yesim Aydinok, Ali Taher
Effective iron chelation therapy is an important part of treatment in patients with transfusion-dependent thalassaemia and lower-risk myelodysplastic syndromes (MDS). Key strategies for optimizing iron chelation therapy include ensuring good adherence and preventing and managing adverse events (AEs). Good adherence to iron chelation therapy with deferoxamine and deferasirox has been linked to improved survival and/or reductions in complications related to iron overload; however, maintaining good adherence to iron chelators can be challenging...
June 14, 2018: European Journal of Haematology
Pei-Chi Hsiao, Wan-Hui Yu, Shih-Chieh Lee, Mei-Hsiang Chen, Ching-Lin Hsieh
BACKGROUND: The responsiveness and predictive validity of the Tablet-based Symbol Digit Modalities Test (T-SDMT) are unknown, which limits the utility of the T-SDMT in both clinical and research settings. AIM: The purpose of this study was to examine the responsiveness and predictive validity of the T-SDMT in inpatients with stroke. DESIGN: A follow-up, repeated-assessments design. SETTING: One rehabilitation unit at a local medical center...
June 14, 2018: European Journal of Physical and Rehabilitation Medicine
Katarzyna Kuczyńska, Piotr Grzonkowski, Łukasz Kacprzak, Jolanta B Zawilska
Fentanyl is a potent synthetic opioid used as a narcotic analgesic supplement in general and regional anesthesia as well as in management of persistent, severe chronic pain. Alarming epidemiological and forensic medicine reports, accumulated mainly during the last two decades, point to a growing increase in illicit use of fentanyl, mainly in North America and Europe. Toxicological data indicates that fentanyl use is inextricably linked with polydrug use. There are two main sources of fentanyl on the "recreational" drug market...
June 2, 2018: Forensic Science International
B Démuth, D L Galata, A Balogh, E Szabó, B Nagy, A Farkas, E Hirsch, H Pataki, T Vigh, J Mensch, G Verreck, Z K Nagy, G Marosi
Itraconazole is a fungicide drug which has low bioavailability due to its poor water solubility. Amorphous solid dispersion (ASD) is a tool that has the potential to greatly increase the dissolution rate and extent of compounds. In this work, the dissolution of tablets containing the ASD of itraconazole with either hydroxypropyl methylcellulose (HPMC) or vinylpyrrolidone-vinyl acetate copolymer (PVPVA) was compared in order to find a formulation which can prevent the drug from the precipitation caused by magnesium stearate...
June 11, 2018: European Journal of Pharmaceutical Sciences
Joo Hyung Lee, Hyung Sun Kim, Ji Sub Kim, Dong Ki Lee, Jin Hong Lim
RATIONALE: Immunoglobulin (Ig)G4-related pseudotumors of the liver are very rare diseases that are difficult to distinguish from malignant tumors. They can be usually improved by steroid therapy. Actinomycosis is a chronic, suppurative, granulomatous infection, for which immune suppression is a predisposing factor. It can also mimic malignant tumors. PATIENT CONCERNS: A 67-year-old man presented with mild abdominal discomfort and a 5-kg weight loss for 3 months...
June 2018: Medicine (Baltimore)
Yun-Yun Guan, Yeqing Zhang, Li-Xin Liu, Hai-Dong Li, Dan Xue, Wei-Lian Bao, Guan Ye, Xiaoyan Shen
Rheumatoid arthritis (RA) severely affects the quality life of patients due to its high association with disability. Traditional Chinese medicines have been reported to exert notable therapeutic effects on RA. The Chinese medicinal prescription Wang‑Bi Tablet (WB) has been successfully used to clinically treat RA for many years; however, its pharmacological mechanism of action is largely unclear. In the present study, adjuvant‑induced arthritis (AIA) rats were used to evaluate the anti‑inflammatory effects of WB and western blotting was used to explore the molecular mechanisms...
June 8, 2018: International Journal of Molecular Medicine
Sowjanyaa Jenarthanan, Chandana Subbarao
Introduction: Pain of endodontic origin is of concern to both the patient and the clinician. Expectation of a painful experience can increase the patient's anxiety levels, making treatment more difficult. Management of endodontic pain is one of the challenging aspects in endodontics. Objective: To evaluate whether the intraligamentary mode of administration of diclogfenac sodium is effective in abating endodontic pain during interappointment visits. Aim: The purpose of this clinical trial is to evaluate the analgesic efficacy of diclofenac sodium administered through oral and intraligamentary routes in reducing postendodontic pain...
May 2018: Journal of Conservative Dentistry: JCD
Bożena Muszyńska, Agata Krakowska, Jan Lazur, Barbara Jękot, Łukasz Zimmer, Agnieszka Szewczyk, Katarzyna Sułkowska-Ziaja, Ewa Poleszak, Włodzimierz Opoka
Chlorella vulgaris Beijerinck is a spherical, green alga belonging to the genus Chlorella and family Chlorellaceae. It has high nutritional value and shows multiple biological effects. Dietary supplements that contain extracts of C. vulgaris are sold in the form of tablets, capsules, powders, and aqueous solutions. To the best of our knowledge, this is the first study to determine the content of bioelements (zinc, iron, and magnesium), phenolic compounds, and lutein before and after incubation with artificial digestive juices from preparations containing C...
2018: Journal of Applied Phycology
Bhargav Patel, Arvind G Jangid, B N Suhagia, Nirmal Desai
An isotope dilution selective and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method has been developed for the simultaneous determination of hydrochlorothiazide (HCTZ) and ramipril in human plasma through a new concept of periodical polarity switching. Extraction of HCTZ, ramipril and their deuterated analogs as internal standards (ISs) was carried out from 150 μL of human plasma by solid-phase extraction method. Chromatographic separation of analytes was performed on Hypurity C18 (150 mm × 4...
June 12, 2018: Journal of Chromatographic Science
Budi Prasaja, M Maulana Syabani, Endah Sari, Uci Chilmi, Prawitasari Cahyaningsih, Theresia Weliana Kosasih
Sevelamer carbonate is a cross-linked polymeric amine; it is the active ingredient in Renvela® tablets. US FDA provides recommendation for demonstrating bioequivalence for the development of a generic product of sevelamer carbonte using in-vitro equilibrium binding study. A simple UV-vis spectrophotometry method was developed and validated for quantification of free phosphate to determine the binding parameter constant of sevelamer. The method validation demonstrated the specificity, limit of quantification, accuracy and precision of measurements...
June 12, 2018: Drug Research
Frank Kloprogge, Lesley Workman, Steffen Borrmann, Mamadou Tékété, Gilbert Lefèvre, Kamal Hamed, Patrice Piola, Johan Ursing, Poul Erik Kofoed, Andreas Mårtensson, Billy Ngasala, Anders Björkman, Michael Ashton, Sofia Friberg Hietala, Francesca Aweeka, Sunil Parikh, Leah Mwai, Timothy M E Davis, Harin Karunajeewa, Sam Salman, Francesco Checchi, Carole Fogg, Paul N Newton, Mayfong Mayxay, Philippe Deloron, Jean François Faucher, François Nosten, Elizabeth A Ashley, Rose McGready, Michele van Vugt, Stephane Proux, Ric N Price, Juntra Karbwang, Farkad Ezzet, Rajesh Bakshi, Kasia Stepniewska, Nicholas J White, Philippe J Guerin, Karen I Barnes, Joel Tarning
BACKGROUND: The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine levels have been reported in young children and in pregnant women during their second and third trimester. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties of lumefantrine and the pharmacokinetic properties of its metabolite, desbutyl-lumefantrine, in order to inform optimal dosing regimens in all patient populations...
June 2018: PLoS Medicine
Wei Hu, Mei Chen, Le Zhou, Tingjun Zhong, Xiaotao Yuan, Feiwu Chen, Lanying Zhang
In this work, a bistable polymer framework liquid crystal (PFLC) thin film by thermal curing of epoxy monomers with two different thiols, a traditional flexible-structure thiol and a novel original rigid-structure thiol has been successfully fabricated, combining a novel mixed morphology of polymer matrix and cholesteric liquid crystals with negative dielectric anisotropy. The polymer framework morphology has been presented by curing two types of epoxy monomers with two types of thiols, and the liquid crystals tend to be focal conic textures with large size domains at the initial state in the PFLC film, so that it has a moderate light transmissivity at this state between the transparent state and the opaque state...
June 12, 2018: ACS Applied Materials & Interfaces
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