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"Cowper's glands"

A Grahofer, H Nathues, C Gurtner
The present report describes a case of multicystic degeneration of the Cowper's gland in a 1.3-year-old purebred Large White intact boar with reduced fertility in Switzerland. Based on the case history, a general physical examination, an andrological investigation and a transrectal ultrasonography combined with a subsequent thorough pathological examination including histology a multicystic degeneration of the Cowper's gland were diagnosed. The case indicates that cystic degeneration of the bulbourethral gland should be contemplated in the differential diagnoses of andrological disorders even though it has not been described in pigs so far...
August 28, 2016: Reproduction in Domestic Animals, Zuchthygiene
Miao Zhang, Curtis Pettaway, Raghu Vikram, Pheroze Tamboli
Primary adenoid cystic carcinoma of the urethra is uncommon with only 9 cases reported in the medical literature; all tumors arose from Cowper's glands. Herein we report the histological features and immunohistochemical characteristics of one patient with primary adenoid cystic carcinoma involving the entire posterior urethra, prostate gland, corpus spongiosum, corpora cavernosa, urogenital diaphragm, perianal soft tissue and muscularis propria layer of rectum. We also review other published cases to evaluate the prognosis and treatment...
August 20, 2016: Human Pathology
F F Mouafo Tambo, C Kamadjou, T Djeumi, A S Nwaha Makon, G Fossi, C Le Coultre, O G Andze, M A Sosso, P Y Mure
Syringocele or dilatation of the duct of the bulbo-urethral (Cowper's) gland is usually of congenital origin but can be acquired. It is a very rare deformity, <10 cases have been reported in literature. The main objective is to describe an additional case of syringocele of Cowper's glands and review the literature. An 18-month-old infant presented with a history of acute urinary retention 3 days after birth and a cystostomy was done. Voiding cystourethrogram was normal and cystourethroscopy showed a syringocele...
July 2016: African Journal of Paediatric Surgery: AJPS
Mohannad A Awad, Amjad Alwaal, Catherine R Harris, Uwais B Zaid, Thomas W Gaither, E Charles Osterberg, Benjamin N Breyer
Cystic dilatation of bulbourethral gland ducts (Cowper's gland syringocele) is a rare abnormality. The condition has been described among pediatric populations, but it is uncommon in adults. It can be asymptomatic or present with obstructive and irritative urinary symptoms. We report a case of a symptomatic imperforate Cowper's syringocele in a young patient that was successfully managed with transurethral unroofing of the cyst.
2016: Case Reports in Urology
Santosh Surana, Mohamed Elshazly, Adel Allam, Sateesh Jayappa, Deena AlRefai
Cowper's gland syringocele is an uncommon, underdiagnosed cystic dilatation of Cowper's gland ducts showing various radiological patterns. Herein we report a rare case of giant Cowper's gland syringocele in an adult male patient, with description of MRI findings and management outcome.
2015: Case Reports in Urology
Ferran Algaba, Isabel Trias
The diagnosis of prostate cancer is made based on the architecture of the glandular proliferation and nuclear atypia, but some normal structures (seminal vesicle, Cowper's glands, prostatic central zone) or nonneoplastic proliferative lesions can mimic carcinoma. Of the 3 patterns of prostate cancer--solid, cribriform, and microglandular, the microglandular pattern is the one that imitates carcinoma most frequently on needle biopsy. The demonstration of basal cells can be the best method to identify these prostate cancer mimickers...
February 2015: Analytical and Quantitative Cytopathology and Histopathology
Romeo Teodor Cristina, Flavia Hanganu, Eugenia Dumitrescu, Florin Muselin, Monica Butnariu, Adriana Constantin, Viorica Chiurciu
The impact of exogenic testosterone (T): 1.5 and 3.0 mg/ and 19-nortestosterone 17-decanoate (ND): 1.5 and 7.5 mg/ in castrated male rats was evaluated based on: (a) weight increase of the androgen target tissues, respecting the Hershberger methodology; (b) the 17α and β-testosterone, 17 α and β-estradiol and 17 α and β-nortestosterone levels using the GC-MS/MS technique; and (c) observation of the serum free thyroxine levels (T4). Results revealed that T and ND significantly increased the weight of androgen target tissues as follows: ND was more influential on seminal vesicles, levator ani-bulbocavernosus muscle (LABC) and Cowper's glands and T (at a dose of 3...
2014: PloS One
M J Quinn, D I Bannon, A M Jackovitz, T L Hanna, A A Shiflett, M S Johnson
The explosive 3-nitro-1,2,4-triazol-5-one (NTO) is an insensitive formulation developed to replace high energetics that are susceptible to accidental detonation from heat, shock, and impact. Although studies have shown NTO to be nontoxic at acute exposures, recent subacute and subchronic tests have demonstrated effects on testes and subsequent sperm production in rats. This study assessed endocrine disruption as a potential mechanism for these reproductive effects via the Hershberger and uterotrophic bioassays...
September 2014: International Journal of Toxicology
Xiaoyan Wang, Tingfeng Chen, Chengyi Song, Bo Gao, Yani Zhang
Stra8 (Stimulated by Retinoic Acid 8) is considered a meiotic gatekeeper gene. Using reverse transcriptase PCR and rapid amplification of cDNA ends (RACE), the complete sequence of the pig Stra8 gene was cloned. Bioinformatics analyses of this sequence were performed. Using semi-quantitative methods, the expression characteristics of Stra8 in Testis, cauda epididymis, body epididymis, caput epididymis, seminal vesicles, prostate gland, Cowper's gland, heart, liver, spleen, lung, kidney, stomach, hypothalamus, pituitary gland, cerebrum, cerebellum, and hippocampus of adult Meishan boar and sow tissues were examined...
2014: International Journal of Molecular Sciences
A O Adebayo, A K Akinloye, S G Olukole, M O Oyeyemi, V O Taiwo, A O Ihunwo, B O Oke
The present study examines the structure and ultrastructure of the bulbourethral glands in 10 sexually matured male greater cane rats raised in captivity. Following anaesthesia, the rats were perfusion-fixed transcardially and the bulbourethral glands dissected out. Upon morphologic and morphometric analysis, the Cowper's glands were observed to have an average volume of 0.24±0.08 ml, a diameter of 6.3±0.6 mm and weighs 0.199±0.06 g. The paired, gourd-shaped tubuloalveolar glands were surrounded by dense connective tissues and separated into lobules by capsular septae...
February 2015: Anatomia, Histologia, Embryologia
Charles E Myers, Zoran Gatalica, Anthony Spinelli, Michael Castro, Erica Linden, Oliver Sartor, Mathew Sargent
Cancer of Cowper's gland is a very rare cancer. This case represents the 9th case in the medical literature. As such, there are no phase II or phase III trials to guide treatment. In this article, we report the successful treatment of a patient over a 7-year period guided solely by molecular profiling. Through multiple cycles to treatment, the cancer was controlled using drugs targeting c-kit, as the cancer steadily increased the expression of c-kit. This report also documents the use of a novel drug combination based on sunitinib that was well tolerated and may warrant testing in other c-kit-dependent cancers...
January 2014: Case Reports in Oncology
Christian I Villeda-Sandoval, Gustavo Romero-Vélez, Andrés Lisker-Cervantes, Mariano Sotomayor de Zavaleta, Alicia Trolle-Silva, Daniel Montante Montes de Oca, Ricardo Castillejos-Molina
We report what to our knowledge is the first case of a giant multicystic cystadenoma of the Cowper's glands. An otherwise healthy 41-year-old man presented with acute urinary retention. Physical examination showed a perineal mass. Different imaging techniques demonstrated a multicystic tumor and en bloc excision was performed. Histological evaluation showed that the tumor arised from the bulbourethral glands; immunohistochemistry proved positive staining for high molecular weight cytokeratin. CASE HYPOTHESIS: Cystic tumors in the pelvis can arise from different structures...
September 2013: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Eva Compérat, Justine Varinot, John R Srigley
The diagnosis of prostate cancer (PCa), especially limited adenocarcinoma on needle biopsy, is often challenging. Before making diagnosis of PCa, it is prudent for the pathologist to consider different benign patterns that may lead to a false positive interpretation. Histoanatomic structures such as seminal vesicles, Cowper's glands and paraganglia along with hyperplasia, atrophy with its different patterns and adenosis may generate difficulties in differential diagnosis. Furthermore, inflammatory processes and post-treatment changes may cause problems...
August 2013: Annales de Pathologie
Masaharu Fukunaga
This case report describes a tubulosquamous polyp resembling a penis in the uterine cervix. A 34-yr-old, gravida 0, para 0, woman showed an 18 × 8 × 5 mm polypoid lesion in the uterine ectocervix. The polyp had a penis-like appearance; the tip looked like glans penis and the middle portion resembled the shaft of the penis. Its surface was covered by squamous epithelium, and tissues resembling those of a urethra, corpus spongiosum penis, and external orifice urethra were observed. Foreskin-like tissues were also observed, although a corpus cavernosum penis was not seen...
July 2013: International Journal of Gynecological Pathology
Fangbai Wu, Ellen Park, Unni Udayasankar
No abstract text is available yet for this article.
August 2013: Journal of Urology
Keith D Bohman, Adeboye O Osunkoya
Mucin-producing tumors of the prostate include both primary and secondary tumors with mucinous differentiation or features involving the prostate gland. These tumors are relatively rare and have variable prognostic and therapeutic implications. Primary mucinous (colloid) adenocarcinoma of the prostate is defined as prostatic adenocarcinoma with mucinous differentiation involving 25% or more of the entire tumor. Another primary tumor of the prostate that may have mucinous features is primary mucin-producing urothelial-type adenocarcinoma of the prostate (mucinous prostatic urethral adenocarcinoma)...
November 2012: Advances in Anatomic Pathology
Yanjun Tan, Hengjuan Wang, Yan Song, Hui Yang, Xudong Jia, Ning Li
OBJECTIVE: To study the potential endocrine disrupting effects of bifenthrin (BIF) by using uterotrophic assay and Hershberger assay. METHODS: In uterotrophic assay, 60 female SD rats were randomly divided into 6 groups, 10 rats per group. Rats in bifenthrin-treated groups were given different doses of bifenthrin (1.47, 4.41 and 13.23 mg/kg BW by gavage for 3 consecutive days). Rats in negative control groups were given corn oil by gavage. Rats in ethinyl estradiol (EE) oral positive control groups were given EE 1...
May 2012: Wei Sheng Yan Jiu, Journal of Hygiene Research
T Keeley, P D McGreevy, J K O'Brien
Devil facial tumour disease (DFTD) is the cause of the rapid decline of wild Tasmanian devils. Female devils are seasonal breeders with births peaking during autumn (i.e. March) but the degree of reproductive seasonality in male devils is unknown. The objective of this study was to examine the potential effects of season and DFTD on reproductive function in male devils (n=55). Testicular (1.90±0.23 g) and epididymal (0.90±0.06 g) weights were maximal during autumn and spring (P<0.05), whereas prostate (3...
2012: Reproduction, Fertility, and Development
Pierluigi Imbimbo, Lorenzo Castigliego, Andrea Armani, Bartolomeo Biolatti, Francesca Tiziana Cannizzo, Daniela Gianfaldoni, Alessandra Guidi
A gross pathology and histological investigation was carried out on bovine target organs of anabolic substances in the Molise Region (Italy). One hundred forty-four bovines (12-24 months old, 123 males and 21 females) were included in the survey. An antemortem assessment of their behavior and clinical examination were performed. After slaughter, samples of prostate, Cowper's glands, Bartholin's glands, mammary gland, ovaries, thymus and thyroid were collected, inspected and processed for histopathology, as suggested in the guidelines of the Italian national program for residue surveillance (PNR)...
October 2012: Journal of Veterinary Medical Science
E V Chandrasekaran, Jun Xue, Jie Xia, Robert D Locke, Shilpa A Patil, Sriram Neelamegham, Khushi L Matta
While glycosyltransferases are known to display unidirectional enzymatic activity, recent studies suggest that some can also catalyze readily reversible reactions. Recently, we found that mammalian sialyltransferase ST3Gal-II can catalyze the formation of CMP-NeuAc from 5'-CMP in the presence of a donor containing the NeuAcα2,3Galβ1,3GalNAc unit [Chandrasekaran, E. V., et al. (2008) Biochemistry 47, 320-330]. This study shows by using [9-(3)H]- or [(14)C]sialyl mucin core 2 compounds that ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcα2,3Galβ1,3GalNAc unit and also radiolabels sialyl residues in gangliosides GD1a and GT1b, but not GM1...
November 8, 2011: Biochemistry
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