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JOURNAL ARTICLE
Helalah K Alenizy, May H AlQahtani, Sarah A Aleban, Reham I Almuwallad, Lolwah A Binsuwaidan, Durrah W Alabdullah, Asma E Althomali
Introduction Vaginal discharge (VD) is a common condition that affects women during their childbearing years and often requires medical attention. It results from the physiological secretion of cervical and Bartholin's glands, as well as the shedding of vaginal epithelial cells caused by bacterial action in the vagina, which alters the acidic environment of the vagina. Experiencing vaginal symptoms is a common reason for seeking medical attention, especially among women during their reproductive years...
March 2024: Curēus
#2
Soumiya Samba, Mohammed Amine Guerrouaz, Ahmed Bensghier, Soufiane Berhili, Mohamed Moukhlissi, Loubna Mezouar
Adenoid cystic carcinoma (ACC) of the vulva represents a highly uncommon type of female malignancy. Due to the absence of specific treatment guidelines, such cases are typically managed by the treatment protocols for vulvar cancer. Here, we report the case of a 52-year-old woman who presented with a painful right vulvar mass, leading to a diagnosis of ACC of the vulva after biopsy and immunohistochemical analysis. She underwent vulvectomy, bilateral inguinal lymphadenectomy, and targeted radiotherapy, and no evidence of recurrence has been found for three years, with ongoing monitoring for post-radiation effects...
March 2024: Curēus
#3
Ahmed Salh Alsayed, Tarek Talaat Harb Elkadi, Mohammed Suliman Alshamari, Azza Tawfik Attallah
INTRODUCTION: Bartholin's gland abscesses are rare in pediatric patients, with limited documented cases. This case report aims to contribute valuable insights into managing this uncommon condition in children. METHODS: A thorough examination and diagnostic workup were conducted on a 4-month-old female infant presenting with labial swelling. Clinical assessment strongly suggested the presence of a Bartholin's gland abscess. A culture of purulent discharge revealed the presence of Escherichia coli and Gram-negative Klebsiella pneumoniae ...
2024: Case Reports in Pediatrics
#4
REVIEW
María Teresa Fernández Figueras, Jacques Alzoghby-Abi Chaker, Miriam Fernandez-Parrado, Adriana García Herrera, María Garrido, Miguel Ángel Idoate Gastearena, Mar Llamas-Velasco, Carlos Monteagudo, José Onrubia, Noelia Pérez Muñoz, Juan José Ríos-Martín, José Luis Rodríguez Peralto, Eduardo Rozas Muñoz, Onofre Sanmartín, Ángel Santos-Briz, Carles Saus, José Manuel Suárez Peñaranda, Verónica Velasco Benito, María José Beato Merino, Ángel Fernandez-Flores
This is the second article in a two-part series published in this journal, in which we examine the histopathological characteristics, as well as the differential diagnosis, of the main entities that present as cystic and pseudocystic structures in cutaneous biopsy. In this second article, we address ciliated cutaneous cysts, branchial cysts, Bartholin's cysts, omphalomesenteric cysts, thymic cysts, thyroglossal duct cysts, synovial cysts, and median raphe cysts, as well as mucocele, ganglion, and auricular and digital myxoid pseudocysts...
2024: Revista Española de Patología
#5
Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel, Mark J Smyth
No abstract text is available yet for this article.
March 21, 2024: Nature Immunology
#6
JOURNAL ARTICLE
Nadeem R Abu-Rustum, Catheryn M Yashar, Rebecca Arend, Emma Barber, Kristin Bradley, Rebecca Brooks, Susana M Campos, Junzo Chino, Hye Sook Chon, Marta Ann Crispens, Shari Damast, Christine M Fisher, Peter Frederick, David K Gaffney, Stephanie Gaillard, Robert Giuntoli, Scott Glaser, Jordan Holmes, Brooke E Howitt, Kari Kendra, Jayanthi Lea, Nita Lee, Gina Mantia-Smaldone, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Mirna Podoll, Kerry Rodabaugh, Ritu Salani, John Schorge, Jean Siedel, Rachel Sisodia, Pamela Soliman, Stefanie Ueda, Renata Urban, Stephanie L Wethington, Emily Wyse, Kristine Zanotti, Nicole McMillian, Sara Espinosa
Vulvar cancer is annually diagnosed in an estimated 6,470 individuals and the vast majority are histologically squamous cell carcinomas. Vulvar cancer accounts for 5% to 8% of gynecologic malignancies. Known risk factors for vulvar cancer include increasing age, infection with human papillomavirus, cigarette smoking, inflammatory conditions affecting the vulva, and immunodeficiency. Most vulvar neoplasias are diagnosed at early stages. Rarer histologies exist and include melanoma, extramammary Paget's disease, Bartholin gland adenocarcinoma, verrucous carcinoma, basal cell carcinoma, and sarcoma...
March 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#7
JOURNAL ARTICLE
Tanner Redlin, Brain Bishop, Tory Durkin, Elizabeth Hultgren
Leiomyomas of the uterus are the most common benign tumours of women in the reproductive age group, affecting up to 40%-50% of women older than 35. In postmenopausal women, the incidence is much lower with an estimated incidence of 1%-2% in women in the 60-80 years old age group. Vulvar leiomyomas are much rarer than their uterine counterparts, accounting for only 0.03% of all gynaecological neoplasms and 0.07% of all vulvar tumours. These tumours are well-circumscribed, painless, solitary growths that affect females of all ages...
March 5, 2024: BMJ Case Reports
#8
JOURNAL ARTICLE
Vishnu Prasad Pulappadi, Smita Manchanda, Ekta Dhamija, Manisha Jana
Pathologies of the vagina are important causes of symptoms related to the genital tract in women. They can be missed on transabdominal ultrasonography (USG), which is the baseline modality used for evaluation of gynaecological complaints. Transperineal USG and MRI are the imaging modalities of choice for evaluation of the vagina. Diseases of the vagina can be grouped depending upon the age group in which they occur. In children and young adults, congenital anomalies like longitudinal or transverse vaginal septum, imperforate hymen, vaginal aplasia or atresia, and rectovaginal fistula can be seen...
February 28, 2024: British Journal of Radiology
#9
JOURNAL ARTICLE
Jacqueline Feinberg, Arnaud Da Cruz Paula, Edaise M da Silva, Fresia Pareja, Juber Patel, Yingjie Zhu, Pier Selenica, Mario M Leitao, Nadeem R Abu-Rustum, Jorge S Reis-Filho, Amy Joehlin-Price, Britta Weigelt
OBJECTIVE: Adenoid cystic carcinoma (AdCC) of the Bartholin's gland (AdCC-BG) is a very rare gynecologic vulvar malignancy. AdCC-BGs are slow-growing but locally aggressive and are associated with high recurrence rates. Here we sought to characterize the molecular underpinning of AdCC-BGs. METHODS: AdCC-BGs (n = 6) were subjected to a combination of RNA-sequencing, targeted DNA-sequencing, reverse-transcription PCR, fluorescence in situ hybridization (FISH) and MYB immunohistochemistry (IHC)...
February 17, 2024: Gynecologic Oncology
#10
JOURNAL ARTICLE
Aya Han, Seiya Kato, Keigo Morinaga, Miki Izumi, Kensuke Kiyokawa
Adenoid cystic carcinoma (ACC) is a major histological type of salivary gland cancer but an uncommon form of vulvar cancer. Salivary gland ACC occasionally dedifferentiates into high-grade carcinoma, resulting in poor prognoses. The dedifferentiated component is usually a poorly differentiated cribriform or solid carcinoma, whereas squamous cell carcinoma (SCC) is exceptional. Herein, we report the case of a 78-year-old woman with vulvar ACC, including an SCC component. She presented with a vulvar nodule that had been present for 30 years and increased in size over the past few years...
January 16, 2024: Kurume Medical Journal
#11
JOURNAL ARTICLE
Nao Wakasugi-Sato, Tatsurou Tanaka, Masafumi Oda, Shinobu Matsumoto-Takeda, Manabu Habu, Shun Nishimura, Osamu Takahashi, Ikuko Nishida, Hiroki Tsurushima, Taishi Otani, Jumpei Tanaka, Susumu Nishina, Daigo Yoshiga, Masaaki Sasaguri, Yasuhiro Morimoto
BACKGROUND: The distribution and drainage of the sublingual gland ducts have various patterns that might be related to sublingual gland-related diseases, including ranula. This study aimed to elucidate the characteristics of the distribution of Bartholin and/or Rivinus ducts in patients with ranula using magnetic resonance (MR) sialography. METHODS: In this retrospective cross-sectional study, the distributions and drainage patterns of sublingual gland ducts on MR sialography were classified in 74 subjects without sublingual gland-related disease as confirmed by both medical history and clinical examination and 15 patients with ranula, respectively...
January 3, 2024: Quantitative Imaging in Medicine and Surgery
#12
REVIEW
Fatemeh Bakouei, Fatemeh Zolfaghari, Parvaneh Mirabi, Zeynab Farhadi, Mouloud Agajani Delavar
OBJECTIVE: There is no consensus on the best option for the management of Bartholin's gland abscesses. This systematic review and meta-analysis aimed to compare the Word catheter placement and marsupialization methods in the management of women with a cyst or abscess of the Bartholin's glands. DATA SOURCES: The PubMed, Scopus, Embase, Web of Science (WoS), and Cochrane Library databases, as well as Google Scholar were searched to retrieve articles published between January 1990 and July 2023, comparing the Word catheter treatment with marsupialization for women with a cyst or abscess of the Bartholin's glands...
January 10, 2024: Journal of Obstetrics and Gynaecology Canada: JOGC
#13
Hao-Yu Li, Dah-Ching Ding
BACKGROUND: We report on the case of a 21-year-old female who could not walk due to a huge Bartholin's cyst occupying the right vulvar region. The patient was treated by marsupialization of the Bartholin's cyst and postoperative antibiotic therapy. CASE SUMMARY: A 21-year-old female without a medical history of sexually transmitted diseases presented to our outpatient clinic with complaints of a painful vulvar lump and a green-yellowish discharge for 4 d. A large Bartholin's cyst, 10 cm in diameter, was suspected over the right side of the vulva...
November 6, 2023: World Journal of Clinical Cases
#14
JOURNAL ARTICLE
Xin Fang, Linfeng Nie, Satwikreddy Putluri, Nan Ni, Laurent Bartholin, Qinglei Li
The transforming growth factor β (TGFβ) superfamily, consisting of protein ligands, receptors, and intracellular SMAD transducers, regulates fundamental biological processes and cancer development. Our previous study has shown that sustained activation of TGFβ receptor 1 (TGFBR1) driven by anti-Mullerian hormone receptor type 2 ( Amhr2 )-Cre in the mouse testis induces the formation of testicular granulosa cell tumors (TGCTs). As Amhr2 -Cre is expressed in both Sertoli cells and Leydig cells, it remains unclear whether the activation of TGFBR1 in Sertoli cells alone is sufficient to induce TGCT formation...
November 27, 2023: Cells
#15
Nandini Komatineni, Krishna Gopal Paul
Vulvar leiomyomas are rare benign tumors originating from smooth muscle cells of the vulvar tissue. We present the case of a 44-year-old female patient complaining of a painless vulval mass for 12 years, gradually increasing from 1x1 cm to 5x4 cm. Clinical assessment initially suggested a Bartholin cyst because of its non-tender and non-fluctuant nature. However, surgical intervention revealed an unexpected diagnosis of vulvar leiomyoma, measuring 5x5x4 cm. The patient underwent successful excision and repair under spinal anesthesia...
October 2023: Curēus
#16
REVIEW
Camilla Turetta, Roberta Mazzeo, Giuseppe Capalbo, Salvatora Miano, Robert Fruscio, Violante Di Donato, Francesca Falcone, Giorgia Mangili, Sandro Pignata, Innocenza Palaia
Bartholin gland carcinoma is an extremely rare disease. Information regarding treatment is scarce and there is no strict consensus on best practice. All studies reporting cases of Bartholin's gland cancer were screened and evaluated for inclusion. Baseline characteristics of studies were extracted. A total number of 290 manuscripts collected were available for the review process. Studies included in a previous systematic review were not duplicated. In total, details of 367 patients were collected, as follows: histological features, clinical presentation, treatment, recurrent rate, treatment of recurrence and outcome...
November 13, 2023: Tumori
#17
Satish Choudhury, Arun K Dora, Gargi Gautam, K Pushpalatha
Vaginal cysts are often encountered in gynaecological outpatient settings. These are usually asymptomatic in their initial course but become symptomatic when their size increases or they get infected. While evaluating such cases, clinical examination plays a vital role in ruling out their differential diagnoses. Imaging studies can complement clinical findings. However, in some instances, the nature of vaginal cysts may not be determined preoperatively until histopathology examination reveals it. We report here a rare case of a posterior vaginal wall cyst that presented as a mass protruding through the vagina...
September 2023: Curēus
#18
Tali Pomerantz, Nicole J Rubin, Anthony N Karnezis, Xiao Zhao, Rebecca Brooks
Clear cell carcinoma (CCC) of the vulva is extremely rare. We report a case of a 54-year-old woman who presented with a 5 cm mass of the mons pubis. She underwent needle biopsy demonstrating CCC. She then underwent radical vulvectomy with bilateral inguinofemoral lymph node dissection. Surgical pathology revealed CCC of the vulva with lymphovascular space invasion (LVSI) and metastatic carcinoma in 1/7 inguinal lymph nodes. The patient has a history of endometriosis, raising suspicion that her CCC could have arisen from endometriosis in the mons...
December 2023: Gynecologic Oncology Reports
#19
JOURNAL ARTICLE
Mojgan Akbarzadeh-Jahromi, Negar Taheri, Sadaf Mohajerani, Nasim Taheri, Fatemeh Abiri
Background : Inflammatory lesions and cysts are the most common Bartholin glands pathologic diagnoses. There have been very few reports of benign solid lesions of Bartholin glands such as nodular hyperplasia. Materials and methods : Thirty-two lesions diagnosed as Bartholin duct cyst in the gynecologic specialized institute were reviewed by two expert gynecological pathologists. Results : Using specific criteria, 7 qualified as nodular hyperplasia, 25 as Bartholin duct cyst. The average age of the patients with nodular hyperplasia was 31 years (range, 24 to 43)...
October 19, 2023: International Journal of Surgical Pathology
#20
JOURNAL ARTICLE
Gregor Leonhard Olmes, Georg Peter Breitbach, Anton Tepikin, Adriana Nistor, Erich Franz Solomayer, Bashar Haj Hamoud
The metastasis of a gynecological malignancy to the Bartholin gland is rare. We report the case of a 62-year-old patient who had undergone extensive treatment of metastatic ovarian cancer that involved the liver, spleen, and peritoneum. She presented with painful swelling of the left vulva. Clinical and sonographic examinations showed a solid tumor in loco typico of the Bartholin gland. Surgical excision was performed. The patient died 3 months after the diagnosis of this metastasis. We performed a systematic search of PubMed, which yielded 453 entries...
October 4, 2023: Reproductive Sciences
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