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https://www.readbyqxmd.com/read/29780648/a-case-of-adenoid-cystic-carcinoma-mimicking-a-bartholin-cyst-and-literature-review
#1
Siew Pei Goh, Brian McCully, Matthew Kyle Wagner
Adenoid cystic carcinoma of the Bartholin Gland (BG-ACC) is a rare form of vulval cancer with only approximately 350 reported cases since 1864. A review of available literature and case reports suggests an aggressive nature with protracted clinical symptoms and a tendency for local recurrence despite adequate surgical excision with or without adjuvant radiotherapy. Survival rates of 71% and 59% are reported at five and ten years. This case report endeavours to add to our body of knowledge regarding this rare disease and thus help broaden and improve our understanding of management and treatment success...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742719/cauda-equina-syndrome-following-an-uneventful-spinal-anesthesia-in-a-patient-undergoing-drainage-of-the-bartholin-abscess-a-case-report
#2
Waldo Merino-Urrutia, Milca Villagrán-Schmidt, Priscilla Ulloa-Vásquez, Rubén Carrasco-Moyano, Alberto Uribe, Nicoleta Stoicea, Sergio D Bergese
RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29660598/first-in-human-phase-1-dose-escalation-pharmacokinetic-and-pharmacodynamic-study-of-the-oral-dual-pi3k-and-mtorc1-2-inhibitor-pqr309-in-patients-with-advanced-solid-tumors-sakk-67-13
#3
Andreas Wicki, Nicholas Brown, Alexandros Xyrafas, Vincent Bize, Hanne Hawle, Simona Berardi, Nataša Cmiljanović, Vladimir Cmiljanović, Michael Stumm, Saša Dimitrijević, Richard Herrmann, Vincent Prêtre, Reto Ritschard, Alexandar Tzankov, Viviane Hess, Alexa Childs, Cinta Hierro, Jordi Rodon, Dagmar Hess, Markus Joerger, Roger von Moos, Cristiana Sessa, Rebecca Kristeleit
BACKGROUND: PQR309 is an orally bioavailable, balanced pan-phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) C1 and mTORC2 inhibitor. PATIENTS AND METHODS: This is an accelerated titration, 3 + 3 dose-escalation, open-label phase I trial of continuous once-daily (OD) PQR309 administration to evaluate the safety, pharmacokinetics (PK) and pharmacodynamics in patients with advanced solid tumours. Primary objectives were to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D)...
April 13, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29552629/a-persistent-mass-a-case-of-aggressive-angiomyxoma-of-the-vulva
#4
B N Brzezinska, A E Clements, K S Rath, G C Reid
We present a case of aggressive angiomyxoma of the vulva. The patient presented with a persistent, enlarging vulvar mass, initially misdiagnosed as a Bartholin gland cyst. The patient underwent wide local excision, which resulted in total resection of the mass. Final pathology was consistent with aggressive angiomyxoma, a rare soft tissue tumor with a predilection for the female pelvis. Though rare, it is important to consider in the differential diagnosis of a pelvic mass, given the locally aggressive nature of this tumor and propensity for recurrence...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29492231/potential-delay-in-the-diagnosis-of-vulvar-cancer-and-associated-risk-factors-in-women-treated-in-german-gynecological-practices
#5
Jennifer Muigai, Louis Jacob, Konstantinos Dinas, Karel Kostev, Matthias Kalder
The goal of this study was to estimate a potential delay in the diagnosis of vulvar cancer and identify associated risk factors in women treated in gynecological practices in Germany. The current study sample included 1,652 women from 218 gynecological practices who received an initial diagnosis of vulvar cancer (ICD 10: C51) between January 2000 and December 2015 (index date). After applying several exclusion criteria, 505 non-cancer controls were matched (1:1) to 505 vulvar cancer cases based on age, health insurance status, and index date...
February 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29458890/a-vulvar-mass-as-the-first-presentation-in-colorectal-carcinoma-an-unusual-site-of-metastasis-masquerading-a-primary-cancer
#6
Tzu-Yin Tang, Tao-Yeuan Wang
OBJECTIVE: To demonstrate a case with a vulvar metastasis masquerading a primary vulvar malignancy. The clinical and histological features, mechanism, and impact to the prognosis are discussed. CASE REPORT: A 58-year-old woman presented to gynecologist for abnormal vaginal discharge. A vulvar nodule was noticed during physical examination. Biopsy showed adenocarcinoma (ADC) and she was referred for further survey under the impression of Bartholin duct ADC. Later she was further found to also have a colorectal tumor with liver metastasis and subsequently received surgery under the suspicion of a double primary cancer involving the colon and vulva...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29429169/-bartholin-s-gland-nodular-hyperplasia-with-cyst-formation-report-of-a-case
#7
Z Yang, J Wu, H Y Gu, W J Yu, D L Lin, Y J Li
No abstract text is available yet for this article.
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29406447/bartholin-gland-carcinoma-clinicopathologic-features-including-p16-expression-and-clinical-outcome
#8
Tayyebeh Nazeran, Angela S Cheng, Anthony N Karnezis, Anna V Tinker, C Blake Gilks
Bartholin gland carcinomas are rare forms of vulvar malignancy and it is unclear what proportion is associated with high-risk human papilloma virus (HPV) infection. Our hospital archives were searched for all cases of Bartholin gland carcinoma from 1984 to 2017 (n=16). We excluded 3 adenoid cystic carcinomas, which were the subject of a previous study, leaving 13 cases. We reviewed all slides and performed immunostains for p16 as a surrogate biomarker for high-risk HPV. There were 12 squamous cell carcinomas (SCCs), including 1 SCC with transitional-like morphology and 1 papillary SCC, and 1 adenocarcinoma...
February 5, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29364801/-retroperitoneal-cellular-angiofibroma-a-rare-gynecological-entity
#9
Ana Brandão, Sara Campos, João Fraga, Teresa Silva, Fernanda Águas
Cellular angiofibroma is a mesenchymal tumor, described in 1997, without gender preference, that usually appears at age 40. The vulvovaginal area is the most common site in women, mimicking vulvar benign tumors, like Bartholin gland cyst. However, there are a few described cases of a deep or extra-pelvic angiofibroma. Excision is the treatment of choice and the recurrence rate appears to be low. We present the case of a woman with a heterogeneous tumor in the right adnexial region. At the surgery, a retroperitoneal tumor was excised and the histopathological tissue analysis revealed a cellular angiofibroma...
December 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29222207/perineal-aggressive-angiomyxoma-in-a-menopausal-woman
#10
Corentin Deckers, Livia Dumitru, Fabrice Corbisier
Aggressive angiomyxoma (AA) is an uncommon mesenchymal tumour that is principally located in the soft tissues of the pelvis and perineum of young women. The primary features of this benign tumour are a local invasion, a high local recurrence rate and non-specific local clinical signs. We describe the case of a 58-year-old woman, initially treated for a Bartholin's cyst. Histological examination indicated the presence of an AA. The MRI showed a 7 cm soft tissue mass extending from the lateral wall of the vagina, into the left buttock and down into the subcutaneous tissue...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29221447/disruption-of-postnatal-folliculogenesis-and-development-of-ovarian-tumor-in-a-mouse-model-with-aberrant-transforming-growth-factor-beta-signaling
#11
Yang Gao, Xin Fang, David F Vincent, David W Threadgill, Laurent Bartholin, Qinglei Li
BACKGROUND: Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine potential effects of dysregulated TGFB signaling in the ovary using Cre recombinase driven by growth differentiation factor 9 (Gdf9) promoter known to be expressed in oocytes. METHODS: A mouse model containing constitutively active TGFBR1 (TGFBR1CA ) using Gdf9-iCre (termed TGFBR1-CAG9Cre ) was generated...
December 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29201473/recurrent-huge-left-bartholin-s-gland-abscess-for-one-year-in-a-teenager
#12
Athanase Lilungulu, Bonaventura C T Mpondo, Abdallah Mlwati, Dismas Matovelo, Albert Kihunrwa, Balthazar Gumodoka
Bartholin's gland abscess is the commonest worldwide reported abscess in gynaecological outpatient clinics; it has also been reported that Bartholin's gland abscess is three times more common in occurrences compared to Bartholin's gland cyst. It is more common in women who are at risk of acquiring sexually transmitted infections; however, other causes of infection should be investigated to exclude other causes of disease. We present the case of an 18-year-old female patient, a teenager of the reproductive age group, with the recurrent development of huge Bartholin's gland abscess in a period of one year...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29195798/transarterial-embolization-of-a-bartholin-cyst-before-resection
#13
Joshua Cornman-Homonoff, Nigel Pereira, Tamatha B Fenster, Marc H Schiffman
No abstract text is available yet for this article.
November 28, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29062477/bartholin-s-gland-abscess-in-a-prepubertal-female-a-case-report
#14
Veerabhadra Radhakrishna, Rachit Goel, Gaurav Parashar, Ramesh Santhanakrishnan
Bartholin's gland abscess is one of the common inflictions of vulva seen in females of reproductive age group with a recurrence rate of up to 38%. Although it's encountered by many Paediatric Surgeons, it's very rarely reported in prepubertal age. Till date, only six cases have been reported to the best of our knowledge. A seven-year-old female child presented with a recurrent labial abscess. She was found to have Bartholin's gland abscess and was treated with partial excision of cyst wall along with the overlying mucosa and drainage...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28967431/resection-of-the-inferior-pubic-ramus-to-completely-remove-locally-advance-adenoid-cystic-carcinoma-of-bartholin-s-gland
#15
Hidetaka Nomura, Minoru Nagashima, Yoichi Aoki, Nobuhiro Takeshima
OBJECTIVE: Some sections of the pelvic bone can be removed without severe loss of function, including the inferior pubic ramus. Here we report a technique for the complete resection of locally advanced adenoid cystic carcinoma (ACC) of the Bartholin's gland that had invaded the obturator muscle and inferior pubic ramus. METHODS: We chose to operate because there was little evidence of definitive radiotherapy for ACC of the vulva. As preoperative imaging did not suggest lymph node metastasis, we omitted lymphadenectomy...
December 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28914673/nodular-hyperplasia-of-the-bartholin-gland-a-benign-mimicker-of-aggressive-angiomyxoma-a-case-series-and-literature-review
#16
Yun-An Tseng, W Dwayne Lawrence, Shahrzad E Slater
Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. All cases have microscopic features of lobular proliferation of acini and inspissated mucin. One case especially has extensive mucin extravasation mimicking an aggressive angiomyxoma...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28904245/gallstone-ileus-in-an-ederly-patient-case-report
#17
Antonino Tornambè, Giuseppe Tornambè
AIM: To report an another case of gallstone ileus in ederly patient that was treated with simple enterolithotomy. MATERIAL OF STUDY: We report a case of 84 years old female that was admitted with intestinal obstruction. A CT scan suggested small bowel obstruction secondary to gallstone ileus. In relation to the overall clinical condition, we decided to perform a simple enterolithotomy. DISCUSSION: The first case of a cholecysto intestinal fistula with a gallstone within the gastro intestinal tract was described n 1654 by, Thomas Bartholin in a necropsy study...
September 4, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28807231/bartholin-gland-cancer
#18
REVIEW
Violante Di Donato, Assunta Casorelli, Erlisa Bardhi, Flaminia Vena, Claudia Marchetti, Ludovico Muzii, Pierluigi Benedetti Panici
INTRODUCTION: Bartholin gland carcinoma is an extremely rare condition. Because of its, phase III trials have not been carried out, there exists no unanimous consensus on treatment and guidelines are missing. METHODS: All studies reporting cases of Bartholin cancer were collected and screened for the evaluations. Baseline characteristics of studies were extracted and were queried in a database. RESULTS: A total number of 133 manuscripts collected were available for the review process, representing a total number of 275 reported cases...
September 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28783860/differential-diagnosis-between-bartholin-cyst-and-vulvar-leiomyoma-case-report
#19
Kelly Alessandra da Silva Tavares, Thomas Moscovitz, Marcos Tcherniakovsky, Luciano de Melo Pompei, César Eduardo Fernandes
Genital leiomyomas are rare tumors that can often be misdiagnosed as Bartholin cyst. We report a case of a 32-year-old patient who had a cystic nodulation in the left labium majus that was suggestive of Bartholin cyst. A resection surgery was performed, and the definitive histopathology diagnosis was vulvar leiomyoma. The macroscopic features of cystic lesions difficult the differential diagnosis between leiomyoma and Bartholin cyst; therefore, a histopathologic examination is often recommended.
August 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28764246/a-report-of-two-cases-of-giant-bartholin-gland-cysts-successfully-treated-by-excision-with-review-of-literature
#20
Anji Reddy Kallam, Vandana Kanumury, Naveena Bhimavarapu, Bhavika Soorada
Bartholin's gland cysts are one of the common vulval masses that may start as asymptomatic cysts but if left untreated, may become large and infected requiring medical attention. We are presenting two interesting and rare cases of giant Bartholin cyst and their treatment in this case report. Two female patients of perimenopausal age presented with giant vulval cysts to the outpatient department of Obstetrics and Gynaecology. They reached a size of 10 cm and 20 cm diameter respectively, presenting with some diagnostic and later reconstruction of the labia majus...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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