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https://www.readbyqxmd.com/read/29402732/female-sexual-dysfunction-a-systematic-review-of-outcomes-across-various-treatment-modalities
#1
REVIEW
James M Weinberger, Justin Houman, Ashley T Caron, Jennifer Anger
BACKGROUND: Female sexual dysfunction (FSD) is a highly prevalent condition. Nevertheless, the scientific literature has only recently begun to accumulate evidence for treatment modalities that address the underlying etiologies of FSD. AIM: The purpose of this systematic review is to elucidate what treatments are effective across the various symptom complexes of FSD. METHODS: Utilizing Meta-analysis of Observational Studies in Epidemiology guidelines, we conducted a systematic review of PubMed, EMBASE, clinicaltrials...
February 3, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29402703/tibial-nerve-stimulation-to-drive-genital-sexual-arousal-in-an-anesthetized-female-rat
#2
Lauren L Zimmerman, Indie C Rice, Mitchell B Berger, Tim M Bruns
BACKGROUND: There is clinical evidence that percutaneous tibial nerve stimulation can positively benefit women with female sexual interest/arousal disorder, yet no studies have explored the potential mechanisms further. AIM: To investigate the effect of tibial nerve stimulation on vaginal blood perfusion (VBP) in an anesthetized rat model. METHODS: 16 ketamine-anesthetized rats were surgically implanted with a nerve cuff electrode on 1 tibial nerve...
February 3, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29289554/efficacy-and-safety-of-on-demand-use-of-2-treatments-designed-for-different-etiologies-of-female-sexual-interest-arousal-disorder-3-randomized-clinical-trials
#3
Adriaan Tuiten, Kim van Rooij, Jos Bloemers, Christoph Eisenegger, Jack van Honk, Rob Kessels, Sheryl Kingsberg, Leonard R Derogatis, Leo de Leede, Jeroen Gerritsen, Hans P F Koppeschaar, Berend Olivier, Walter Everaerd, Henderik W Frijlink, Daniël Höhle, Robert P J de Lange, Koen B E Böcker, James G Pfaus
BACKGROUND: In women, low sexual desire and/or sexual arousal can lead to sexual dissatisfaction and emotional distress, collectively defined as female sexual interest/arousal disorder (FSIAD). Few pharmaceutical treatment options are currently available. AIM: To investigate the efficacy and safety of 2 novel on-demand pharmacologic treatments that have been designed to treat 2 FSIAD subgroups (women with low sensitivity for sexual cues and women with dysfunctional over-activation of sexual inhibition) using a personalized medicine approach using an allocation formula based on genetic, hormonal, and psychological variables developed to predict drug efficacy in the subgroups...
December 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29282516/the-morbidity-of-sexual-dysfunction-of-125-chinese-women-following-different-types-of-radical-hysterectomy-for-gynaecological-malignancies
#4
Xueqin Wang, Chunlin Chen, Ping Liu, Weili Li, Liling Wang, Yunlu Liu
PURPOSE: Due to early detection and effective treatment, quality of sexual life of patients with gynaecological malignancies has become an important issue. However, the morbidity of sexual dysfunction and the proportion of different kinds of sexual dysfunction after radical hysterectomy are unclear. The aim of the current study was to assess the morbidity of sexual dysfunction and to conduct multivariate logistic regression analysis of patients' sexual dysfunction. METHODS: Between July 2007 and December 2012, 125 women underwent radical hysterectomy, modified radical hysterectomy, and nerve-sparing radical hysterectomy were administered a self-reported sexual function questionnaire...
December 27, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29225554/recent-developments-in-psychopharmaceutical-approaches-to-treating-female-sexual-interest-and-arousal-disorder
#5
REVIEW
Stephanie Both
Purpose of Review: This review summarizes the recent literature and empirical studies on psychopharmacological approaches to treating female sexual interest/arousal disorder (FSIAD). Recent Findings: Several new drugs for FSIAD that are intended to increase sexual responsiveness by influencing central excitatory and inhibitory neuromodulatory processes are under development. Studies on flibanserin resulted in the first approved medication for the treatment of low sexual desire in premenopausal women...
2017: Current Sexual Health Reports
https://www.readbyqxmd.com/read/29198504/female-sexual-dysfunction-medical-and-psychological-treatments-committee-14
#6
Sheryl A Kingsberg, Stanley Althof, James A Simon, Andrea Bradford, Johannes Bitzer, Joana Carvalho, Kathryn E Flynn, Rossella E Nappi, Jennifer B Reese, Roya L Rezaee, Leslie Schover, Jan L Shifrin
INTRODUCTION: Since the millennium we have witnessed significant strides in the science and treatment of female sexual dysfunction (FSD). This forward progress has included (i) the development of new theoretical models to describe healthy and dysfunctional sexual responses in women; (ii) alternative classification strategies of female sexual disorders; (iii) major advances in brain, hormonal, psychological, and interpersonal research focusing on etiologic factors and treatment approaches; (iv) strong and effective public advocacy for FSD; and (v) greater educational awareness of the impact of FSD on the woman and her partner...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29176500/a-pilot-study-of-a-topical-intervention-for-treatment-of-female-sexual-dysfunction
#7
Adel Abdel-Wadood Gomaa, Nermeen M Abdel Aziz, Romany H Thabet, Howieda A Fouly, Sara H Altellawy, Ghada A Gomaa
PURPOSE/BACKGROUND: Many investigators reported that pharmacological treatment of female sexual dysfunction (FSD) has been a promising field yet to be explored. The purpose of this pilot study was to investigate the efficacy and safety of a topical cream containing small concentrations of three vasodilators with different mechanisms of action in treating FSD. METHODS: In this randomized, controlled pilot trial, premenopausal (n = 30) and postmenopausal (n = 30) cases of 21- to 62-year age range with FSD were allocated randomly into 15 given placebo or 15 given active cream in each group...
February 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29174185/specific-motor-patterns-of-arousal-disorders-in-adults-a%C3%A2-video-polysomnographic-analysis-of-184-episodes
#8
Giuseppe Loddo, Elisa Sessagesimi, Francesco Mignani, Fabio Cirignotta, Susanna Mondini, Laura Licchetta, Francesca Bisulli, Paolo Tinuper, Federica Provini
OBJECTIVE: To compile an objective accurate description of the motor patterns of adult arousal disorders (ADs). METHODS: We reviewed 59 nocturnal video-polysomnographic (VPSG) recordings of 30 adult patients (>15 years) with a history of sleepwalking (SW). We scrutinized the semeiology of all 184 episodes recorded, classifying them into three groups according to three semeiological motor patterns characterized by increasing intensity and complexity: simple arousal movements (pattern I), characterized by head flexion/extension, head flexion/extension and limb movement or head flexion/extension and partial trunk flexion/extension; rising arousal movements (pattern II), characterized by a complete trunk flexion with patient sitting up in bed; and complex arousal with ambulatory movements (pattern III) characterized by SW...
October 7, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29166215/interoception-and-awareness-of-physiological-sexual-arousal-in-women-with-sexual-arousal-concerns
#9
Ariel B Handy, Cindy M Meston
Laboratory studies assessing physiological genital arousal have largely failed to find differences between women with and without female sexual arousal disorder (FSAD). Therefore, it is possible that women with FSAD may be unaware of their genital arousal response. The present study examined the extent to which women with FSAD can report their genital arousal response, as well as the role of interoception (body awareness) in this relationship. Additionally, this study examined the influence of interoception on the relationship between subjective and genital arousal...
November 22, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29110805/a-population-based-epidemiologic-study-of-female-sexual-dysfunction-risk-in-mainland-china-prevalence-and-predictors
#10
Chunni Zhang, Jiali Tong, Lan Zhu, Lei Zhang, Tao Xu, Jinghe Lang, Yu Xie
BACKGROUND: Epidemiologic data on female sexual dysfunction in China are sparse. AIM: To assess the prevalence of risk of female sexual dysfunction in mainland China and its regional and sociodemographic variations and physiologic, pathologic, and behavioral risk factors. METHODS: A survey of the general female population was conducted in mainland China from February 2014 through January 2016. Women were randomly selected using multistage, stratified, cluster sampling...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29095039/women-with-hypoactive-sexual-desire-disorder-versus-sexual-interest-arousal-disorder-an-empirical-test-of-raising-the-bar
#11
Julia I O'Loughlin, Rosemary Basson, Lori A Brotto
In 2013, the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) was published with a major revision to the sexual dysfunction categories, and the diagnosis of female hypoactive sexual desire disorder (HSDD) was replaced with female sexual interest/arousal disorder (SIAD). Since being introduced, concern has been expressed that SIAD inappropriately "raises the bar" for diagnosis. To address these concerns, we sought to evaluate the number of women with a diagnosis of HSDD who also met criteria for SIAD...
November 2, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29066935/female-sexual-dysfunction-a-focus-on-flibanserin
#12
REVIEW
Nicole M Lodise
Flibanserin is the first US Food and Drug Administration (FDA)-approved option for sexual dysfunction, specifically low sexual desire. Until recently, there were no FDA-approved medication options to assist the ~40% of women affected by female sexual dysfunction (FSD). Often, patients report feeling uncomfortable discussing sexual health, identifying a strong need for health care professionals (HCPs) to proactively reach out to patients to identify concerns and initiate a discussion about sexual health and the available treatment options...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29020067/interoception-and-sexual-response-in-women-with-low-sexual-desire
#13
Julia Velten, Lori A Brotto
Sexual concordance is defined as the association between genital response and self-reported sexual arousal. Though one might predict a strong association between sexual concordance and awareness of other internal physiological sensations (termed interoception), past research on sexually healthy women has not found these different domains to be related. The aim of the present study was to test the association between interoception and sexual concordance in a clinical sample of women with Sexual Interest/Arousal Disorder (SIAD)...
2017: PloS One
https://www.readbyqxmd.com/read/28993148/the-sexual-event-diary-sed-development-and-validation-of-a-standardized-questionnaire-for-assessing-female-sexual-functioning-during-discrete-sexual-events
#14
Yvonne van Nes, Jos Bloemers, Peter G M van der Heijden, Kim van Rooij, Jeroen Gerritsen, Rob Kessels, Leonard DeRogatis, Adriaan Tuiten
BACKGROUND: The efficacy of on-demand drugs for hypoactive sexual desire disorder (HSDD) or female sexual interest/arousal disorder (FSIAD) should be assessed using a validated instrument that assesses the discrete sexual events during which the on-demand drug is taken. AIM: To develop and validate an event log for measuring sexual satisfaction and sexual functioning of discrete sexual events. METHODS: Psychometric assessment was carried out on data of 10,959 Sexual Event Diaries (SEDs) collected during three clinical trials in a total of 421 women with HSDD...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28958593/opinion-paper-on-the-diagnosis-classification-of-sexual-arousal-concerns-in-women
#15
Stanley E Althof, Cindy M Meston, Michael A Perelman, Ariel B Handy, Chelsea D Kilimnik, Amelia M Stanton
BACKGROUND: In the professional literature and among our professional societies, female sexual dysfunction nomenclature and diagnostic criterion sets have been the source of considerable controversy. Recently, a consensus group, supported by the International Society for Women's Sexual Health, published its recommendations for nosology and nomenclature, which included only one type of arousal dysfunction, female genital arousal disorder, in its classification system. Subjective arousal was considered an aspect of sexual desire and not part of the arousal phase...
September 22, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28923310/factors-associated-with-specific-diagnostic-and-statistical-manual-of-mental-disorders-fourth-edition-sexual-dysfunctions-in-breast-cancer-survivors-a-study-of-patients-and-their-partners
#16
Susanna B Hummel, Daniela E E Hahn, Jacques J D M van Lankveld, Hester S A Oldenburg, Eva Broomans, Neil K Aaronson
BACKGROUND: Many women develop sexual problems after breast cancer (BC) treatment. Little is known about BC survivors with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) sexual dysfunction and their partners, and the factors associated with their sexual functioning. AIM: To evaluate (i) patient-related and clinical factors associated with (a) specific DSM-IV sexual dysfunctions and (b) level of sexual functioning and sexual distress as reported by BC survivors and (ii) the association between the sexual functioning of BC survivors and that of their partners...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28749253/randomized-crossover-study-investigating-daily-versus-on-demand-vulvar-visnadine-spray-in-women-affected-by-female-sexual-arousal-disorder
#17
Salvatore Caruso, Diletta Mauro, Maria Cariola, Valentina Fava, Agnese Maria Chiara Rapisarda, Antonio Cianci
The aim of the study was to verify the efficacy of vulvar Visnadine spray in premenopausal women affected by female sexual arousal disorder (FSAD). Thirty-eight women aged 25-40 years affected by FSAD were enrolled in the randomized crossover study, by two possible sequences: on-demand, washout, daily (A sequence); and daily, washout, on-demand (B sequence). The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) were used to assess sexual function and sexual distress, respectively...
July 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28657994/pudendal-neuromodulation-as-a-treatment-for-persistent-genital-arousal-disorder-a-case-series
#18
Natalie Gaines, Brian D Odom, Kim A Killinger, Kenneth M Peters
BACKGROUND: Persistent genital arousal disorder (PGAD) is a rare life-altering condition characterized by unwanted, uncomfortable genital sensations or spontaneous orgasms without physical or emotional stimulation. Its etiology remains unclear, and a variety of treatments have been attempted with incomplete resolution. We propose that chronic pudendal neuromodulation (CPN) may be a useful treatment for PGAD symptoms. METHODS: A retrospective chart review was performed for women older than 18 years with a diagnosis of PGAD that had staged neuromodulation with placement of a tined lead at the pudendal nerve...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28635538/clomipramine-trial-for-treatment-resistant-persistent-genital-arousal-disorder-a-case-series
#19
Ejder Akgun Yildirim, Munevver Hacioglu Yildirim, Elif Carpar, Irmak Sarac
INTRODUCTION: Treatment of persistent genital arousal disorder (PGAD), as a chronic and disabling condition, implicates substantial compelling complexities. METHODS: In this case series, seven women diagnosed with PGAD who were referred to the Sexual Dysfunction Unit of Psychotherapy Outpatient Clinic of Bakirkoy Research and Training Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey between 2006 and 2009 were included. All patients were previously resistant to other antidepressants, antipsychotics and antiepileptics...
December 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28513054/is-there-a-common-motor-dysregulation-in-sleepwalking-and-rem-sleep-behaviour-disorder
#20
Mehdi Haridi, Sebastian Weyn Banningh, Marion Clé, Smaranda Leu-Semenescu, Marie Vidailhet, Isabelle Arnulf
This study sought to determine if there is any overlap between the two major non-rapid eye movement and rapid eye movement parasomnias, i.e. sleepwalking/sleep terrors and rapid eye movement sleep behaviour disorder. We assessed adult patients with sleepwalking/sleep terrors using rapid eye movement sleep behaviour disorder screening questionnaires and determined if they had enhanced muscle tone during rapid eye movement sleep. Conversely, we assessed rapid eye movement sleep behaviour disorder patients using the Paris Arousal Disorders Severity Scale and determined if they had more N3 awakenings...
October 2017: Journal of Sleep Research
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