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https://www.readbyqxmd.com/read/28538779/sweat-test-and-cystic-fibrosis-overview-of-test-performance-at-public-and-private-centers-in-the-state-of-s%C3%A3-o-paulo-brazil
#1
Maria Fátima Servidoni, Carla Cristina Souza Gomez, Fernando Augusto Lima Marson, Adyléia Aparecida Dalbo Contrera Toro, Maria Ângela Gonçalves de Oliveira Ribeiro, José Dirceu Ribeiro, Antônio Fernando Ribeiro
Objective: The sweat test (ST) measures chloride levels in sweat and is considered the gold standard for the diagnosis of cystic fibrosis (CF). However, the reliability of a ST depends on their being performed by experienced technicians and in accordance with strict guidelines. Our aim was to evaluate how sweat stimulation, sweat collection, and chloride measurement are performed at 14 centers (9 public centers and 5 private centers) that routinely perform STs in the state of São Paulo, which has the highest frequency of CF in Brazil...
March 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28538744/comorbidities-of-hidradenitis-suppurativa
#2
Martina L Porter, Alexa B Kimball
Hidradenitis suppurativa (HS) is an inflammatory skin disorder with many associated comorbidities, including obesity, metabolic syndrome, smoking, depression, arthritis, autoinflammatory syndromes, inflammatory bowel disease, and genetic syndromes. In addition, HS patients can suffer from a variety of diseases related to the chronic inflammatory nature of their HS such as cardiovascular disease and anemia. An understanding of these comorbidities and associations is essential for the management of HS, and routine screening for these entities should be considered in all HS patients...
June 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28538513/attention-deficit-hyperactivity-disorder-in-children-with-sickle-cell-disease-referred-for-an-evaluation
#3
Melissa A Acquazzino, Meghan Miller, Matthew Myrvik, Robert Newby, John Paul Scott
Neuropsychological deficits, including difficulties with attention, are well described in children with sickle cell disease (SCD). Very little is known about attention deficit hyperactivity disorder (ADHD) in children with SCD. The objective of this study was to determine the proportion of ADHD in children with SCD referred for neuropsychological evaluation. This prospective, cross-sectional study included patients (age, 4 to 18 y) with SCD and completion of a neuropsychological evaluation between December 2013 and March 2016...
May 22, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28538285/teenage-pregnancy-prevention-the-role-of-young-men
#4
Gabriela Vargas, Joshua Borus, Brittany M Charlton
PURPOSE OF REVIEW: Although teenage pregnancy is declining in many parts of the world, it remains associated with considerable social, health, and economic outcomes. Pregnancy prevention efforts focus primarily on young women, with minimal attention to young men. This review highlights recent literature pertaining to the role of young men in pregnancy prevention. RECENT FINDINGS: Young men have varying views on contraception as well as which partner(s) should be responsible for its use...
May 22, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28537925/preoperative-vitamin-d-deficiency-and-postoperative-hypocalcemia-in-thyroid-cancer-patients-undergoing-total-thyroidectomy-plus-central-compartment-neck-dissection
#5
Xiaofei Wang, Jingqiang Zhu, Feng Liu, Yanping Gong, Zhihui Li
BACKGROUND: There appears to be a lack of consensus whether preoperative vitamin D deficiency (VDD) increases the risk of postoperative hypocalcemia and decreases the accuracy of postoperative parathyroid hormone (PTH) in predicting hypocalcemia in thyroid cancer patients undergoing total thyroidectomy (TT) plus central compartment neck dissection (CCND). This study aims to address these issues. METHOD: All consecutive thyroid cancer patients who underwent TT plus CCND were retrospectively reviewed through a prospectively collected database between October 2015 and April 2016 in a tertiary referral hospital...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535494/overdiagnosis-in-breast-cancer-screening-the-impact-of-study-design-and-calculations
#6
Elsebeth Lynge, Anna-Belle Beau, Peer Christiansen, My von Euler-Chelpin, Niels Kroman, Sisse Njor, Ilse Vejborg
Overdiagnosis in breast cancer screening is an important issue. A recent study from Denmark concluded that one in three breast cancers diagnosed in screening areas in women aged 50-69 years were overdiagnosed. The purpose of this short communication was to disentangle the study's methodology in order to evaluate the soundness of this conclusion. We found that both the use of absolute differences as opposed to ratios; the sole focus on non-advanced tumours and the crude allocation of tumours and person-years by screening history for women aged 70-84 years, all contributed to the very high estimate of overdiagnosis...
May 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28535437/comparative-evaluation-of-three-fda-approved-hiv-ag-ab-combination-tests-using-a-genetically-diverse-hiv-panel-and-diagnostic-specimens
#7
Xiaoxing Qiu, Lori Sokoll, Paul Yip, Debra J Elliott, Renu Dua, Phaedre Mohr, Xiao Yan Wang, Megan Spencer, Priscilla Swanson, George J Dawson, John Hackett
BACKGROUND: HIV Ag/Ab combination assays are recommended by CDC for routine screening and several HIV Ag/Ab combination tests are now FDA-approved. Maintaining high specificity and consistent sensitivity across diverse HIV strains is critical for these assays to accurately detect HIV infection and expedite delivery of patient results. OBJECTIVES: To evaluate performance of three FDA-approved HIV tests: ARCHITECT HIV Combo (Abbott), ADVIA Centaur HIV Combo (Siemens) and BioPlex HIV Ag-Ab (Bio-Rad)...
May 13, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28533916/pediatric-intensive-care-stress-ulcer-prevention-pic-up-a-protocol-for-a-pilot-randomized-trial
#8
Mark Duffett, Karen Choong, Jennifer Foster, Elaine Gilfoyle, Jacques Lacroix, Nikhil Pai, Lehana Thabane, Deborah J Cook
BACKGROUND: Despite sparse pediatric data on effectiveness, the majority of critically ill children receive medications to prevent gastrointestinal (GI) bleeding. Stress ulcer prophylaxis may have unintended consequences-increasing the risk of nosocomial infections-which may be more serious and common than the bleeding which these drugs are prescribed to prevent. Randomized controlled trials (RCTs) in pediatric critical care are exceptionally challenging to complete, thus a rigorous pilot RCT is crucial...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28533818/a-novel-bcr-abl1-fusion-gene-with-genetic-heterogeneity-indicates-a-good-prognosis-in-a-chronic-myeloid-leukemia-case
#9
Fen Zhou, Runming Jin, Yu Hu, Heng Mei
BACKGROUND: Chronic myelogenous leukemia (CML) is a pluripotent hematopoietic stem cell disorder caused by the fusion of the BCR and ABL1 genes. Quantitative RT-PCR (qRT-PCR) is a routinely performed screening technique to identify BCR-ABL1 fusion genes, but a limitation of this method is its inability to recognize novel fusions that have not been previously characterized. Next-generation sequencing (NGS) is an effective and sensitive detection method for the determination of novel BCR-ABL1 fusion genes as well as previously characterized ones...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28533524/enhancing-the-genome-editing-toolbox-genome-wide-crispr-arrayed-libraries
#10
Emmanouil Metzakopian, Alex Strong, Vivek Iyer, Alex Hodgkins, Konstantinos Tzelepis, Liliana Antunes, Mathias J Friedrich, Qiaohua Kang, Teresa Davidson, Jacob Lamberth, Christina Hoffmann, Gregory D Davis, George S Vassiliou, William C Skarnes, Allan Bradley
CRISPR-Cas9 technology has accelerated biological research becoming routine for many laboratories. It is rapidly replacing conventional gene editing techniques and has high utility for both genome-wide and gene-focussed applications. Here we present the first individually cloned CRISPR-Cas9 genome wide arrayed sgRNA libraries covering 17,166 human and 20,430 mouse genes at a complexity of 34,332 sgRNAs for human and 40,860 sgRNAs for the mouse genome. For flexibility in generating stable cell lines the sgRNAs have been cloned in a lentivirus backbone containing PiggyBac transposase recognition elements together with fluorescent and drug selection markers...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533198/chlamydia-and-hiv-testing-contraception-advice-and-free-condoms-offered-in-general-practice-a-qualitative-interview-study-of-young-adults-perceptions-of-this-initiative
#11
Leah Ffion Jones, Ellie Ricketts, Katy Town, Claire Rugman, Donna Lecky, Kate Folkard, Anthony Nardone, Thomas Nathan Hartney, Cliodna McNulty
BACKGROUND: Opportunistic chlamydia screening is actively encouraged in English general practices. Based on recent policy changes, Public Health England piloted 3Cs and HIV in 2013-2014, integrating the offer of chlamydia testing with providing condoms, contraceptive information, and HIV testing (referred to as 3Cs and HIV) according to national guidelines. AIM: To determine young adults' opinions of receiving a broader sexual health offer of 3Cs and HIV at their GP practice...
May 22, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28532422/conclusions-in-systematic-reviews-of-mammography-for-breast-cancer-screening-and-associations-with-review-design-and-author-characteristics
#12
Smriti Raichand, Adam G Dunn, Mei-Sing Ong, Florence T Bourgeois, Enrico Coiera, Kenneth D Mandl
BACKGROUND: Debates about the benefits and harms of mammography continue despite the accumulation of evidence. We sought to quantify the disagreement across systematic reviews of mammography and determine whether author or design characteristics were associated with conclusions that were favourable to the use of mammography for routine breast cancer screening. METHODS: We identified systematic reviews of mammography published between January 2000 and November 2015, and extracted information about the selection of evidence, age groups, the use of meta-analysis, and authors' professions and financial competing interest disclosures...
May 22, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28531395/nationwide-survey-of-nutritional-management-in-an-asian-upper-middle-income-developing-country-government-hospitals-combination-of-quantitative-survey-and-focus-group-discussion
#13
K Chittawatanarat, K Tosanguan, U Chaikledkaew, S Tejavanija, Y Teerawattananon
BACKGROUND & AIMS: The objective of this study was to identify the differences in pattern, process, and management of nutrition care in government hospitals in Thailand (an Asian upper-middle income developing country). METHODS: This is a combination of a quantitative nationwide questionnaire survey and focus group discussions. A total of 2300 questionnaires were sent to government hospitals across Thailand. The responders were divided by routine-nutrition screening/assessment unit vs...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530849/allergic-bronchopulmonary-aspergillosis-in-cystic-fibrosis-mr-imaging-of-airway-mucus-contrasts-as-a-tool-for-diagnosis
#14
Gaël Dournes, Patrick Berger, John Refait, Julie Macey, Stephanie Bui, Laurence Delhaes, Michel Montaudon, Olivier Corneloup, Jean-François Chateil, Roger Marthan, Michaël Fayon, François Laurent
Purpose To assess the diagnostic accuracy of mucus contrast characterization by using magnetic resonance (MR) imaging to discriminate allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF). Materials and Methods The study was approved by the local Ethics Committee, and all patients or their parents gave written informed consent. One hundred ten consecutive patients with CF were screened between January 2014 and July 2015. All patients underwent a non-contrast material-enhanced MR protocol that included routine T1-weighted and T2-weighted sequences...
May 22, 2017: Radiology
https://www.readbyqxmd.com/read/28530494/review-anal-intraepithelial-neoplasia-in-hiv-infected-men-who-have-sex-with-men-is-screening-and-treatment-justified
#15
Peter Wasserman, David S Rubin, Glenn Turett
Anal squamous cell carcinoma (SCC) is the fourth most prevalent cancer in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Human papillomavirus (HPV) has been detected in over 90% of anal carcinoma biopsy specimens from MSM, and is considered a necessary, but alone, insufficient factor for carcinogenesis. Anal intraepithelial neoplasia (AIN) may be precursive for SCC, and screening cytology with referral of persons with abnormality for high-resolution anoscopy-guided biopsy, and AIN treatment, has been recommended for prevention...
May 22, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28528899/effect-of-professional-society-recommendations-on-women-s-desire-for-a-routine-pelvic-examination
#16
George F Sawaya, Karen K Smith-McCune, Steven E Gregorich, Michelle Moghadassi, Miriam Kuppermann
BACKGROUND: The American College of Physicians strongly recommends against performing pelvic examinations in asymptomatic, nonpregnant women, citing evidence of harm (false-positive testing, unnecessary surgery) and no evidence of benefit. In contrast, the American Congress of Obstetricians and Gynecologists recommends pelvic examinations in asymptomatic women beginning at age 21 years, citing expert opinion. OBJECTIVE: We sought to evaluate if providing women with professional societies' conflicting statements about pelvic examinations (recommendations and rationales) would influence their desire for a routine examination...
May 18, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28528808/anxiety-screening-during-assessment-of-emotional-distress-in-mothers-of-hospitalized-newborns
#17
Jennifer E McCabe-Beane, Sara M Stasik-O'Brien, Lisa S Segre
OBJECTIVES: To examine the incremental identification of emotional distress in mothers of hospitalized newborns by screening for anxiety in addition to depression and to provide practical information about anxiety screening scales to facilitate instrument selection and screening implementation by nurses in the NICU. DESIGN: In this secondary data analysis, screening data from the recruitment phase of a feasibility trial to evaluate a nurse-delivered counseling intervention for emotionally distressed mothers of newborns in the NICU were used to examine the effect of anxiety screening...
May 18, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28527158/asymptomatic-cryptococcal-antigenemia-in-people-living-with-hiv-plhiv-with-severe-immunosuppression-is-routine-crag-screening-indicated-in-india
#18
S Anuradha, Abhaya Narayana H, Richa Dewan, Ravinder Kaur, K Rajeshwari
BACKGROUND: Cryptococcal meningitis (CM) is a common, life-threatening opportunistic infection (OI) among people living with HIV (PLHIV) in India. Serum Cryptococcal antigen (CrAg) positivity is predictive of future occurrence of CM and pre-emptive treatment reduces its mortality. Routine CrAg screening among PLHIV is not adopted by India's national programme. This study evaluated the prevalence of CrAg and assessed CrAg positivity in predicting all-cause mortality among PLHIV. METHODS: This prospective study was conducted in a tertiary care, public health facility in New Delhi, India...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28526917/do-we-know-the-outcome-predictors-for-cauda-equine-syndrome-ces-a-retrospective-single-center-analysis-of-60-patients-with-ces-with-a-suggestion-for-a-new-score-to-measure-severity-of-symptoms
#19
Alexander König, Lisa Amelung, Marco Danne, Ullrich Meier, Johannes Lemcke
OBJECTIVE: Despite the awareness and familiarity of almost every medical professional with the cauda equine compression syndrome (CES), risk factors for a poor prognosis of the disease remain elusive. Even the relationship between subsequent outcome and the time elapsed from the time of appearance of symptoms to surgery taking place remain obscure. The aim of our study, therefore, was to analyze a relatively large population of our own patients studied consecutively, to identify outcome predictors for CES and to propose a clinical score for CES symptoms (Berlin CES score)...
May 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28526006/cardiometabolic-profile-of-obese-children-in-a-sub-saharan-african-setting-a-cross-sectional-study
#20
Eunice Chedjou-Nono, Suzanne Sap, Simeon-Pierre Choukem, Issa Ngosso Tetanye, Daniel Nebongo, Olivier Koki Ndombo
BACKGROUND: Cardiovascular and metabolic consequences of obesity in children, unlike adults, are still not well understood nor have they been subject to extensive research in Africa. We aimed to identify the cardio-metabolic complications associated with childhood obesity at the early phase of the management of obese children in a reference center in Cameroon. METHODS: In this cross-sectional study conducted from November 2013 to September 2014 and based on World Health Organization (WHO) classification of Obesity (BMI > 3SD under 5 years and BMI > 2SD from 5 and above), we included children aged 3 to 17 years who were being followed up for obesity at the pediatric endocrinology unit of the Mother and Child Center of the Chantal BIYA Foundation in Yaounde, Cameroon...
May 19, 2017: BMC Pediatrics
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