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https://www.readbyqxmd.com/read/28338530/pharmacologic-characterizations-of-a-p2x7-receptor-specific-radioligand-11c-gsk1482160-for-neuroinflammatory-response
#1
Junbin Han, Hui Liu, Chunling Liu, Hongjun Jin, Joel S Perlmutter, Terrance M Egan, Zhude Tu
OBJECTIVE: The P2X7 receptor (P2X7R) is a key regulatory element in the neuroinflammatory cascade that provides a promising target for imaging neuroinflammation. GSK1482160, a P2X7R modulator with nanomolar binding affinity and high selectivity, has been successfully radiolabeled and utilized for imaging P2X7 levels in a mouse model of lipopolysaccharide-induced systemic inflammation. In the current study, we further characterized its binding profile and determined whether [C]GSK1482160 can detect changes in P2X7R expression in a rodent model of multiple sclerosis...
March 23, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28334909/changes-in-awareness-of-cancer-risk-factors-among-adult-new-zealanders-caanz-2001-to-2015
#2
R Richards, B McNoe, E Iosua, A I Reeder, R Egan, L Marsh, L Robertson, B Maclennan, A Dawson, R Quigg, A-C Petersen
Behaviour change, specifically that which decreases cancer risk, is an essential element of cancer control. Little information is available about how awareness of risk factors may be changing over time. This study describes the awareness of cancer risk behaviours among adult New Zealanders in two cross-sectional studies conducted in 2001 and 2014/5.Telephone interviews were conducted in 2001 (n = 436) and 2014/5 (n = 1064). Participants were asked to recall things they can do to reduce their risk of cancer...
February 27, 2017: Health Education Research
https://www.readbyqxmd.com/read/28334865/structure-of-human-pofut1-its-requirement-in-ligand-independent-oncogenic-notch-signaling-and-functional-effects-of-dowling-degos-mutations
#3
Brian J McMillan, Brandon Zimmerman, Emily D Egan, Michael Lofgren, Xiang Xu, Anthony Hesser, Stephen C Blacklow
Protein O-fucosyltransferase-1 (POFUT1), which transfers fucose residues to acceptor sites on serine and threonine residues of epidermal growth factor-like repeats of recipient proteins, is essential for Notch signal transduction in mammals. Here, we examine the consequences of POFUT1 loss on the oncogenic signaling associated with certain leukemia-associated mutations of human Notch1, report the structures of human POFUT1 in free and GDP-fucose bound states, and assess the effects of Dowling-Degos mutations on human POFUT1 function...
March 17, 2017: Glycobiology
https://www.readbyqxmd.com/read/28320714/variability-in-trough-total-and-unbound-teicoplanin-concentrations-and-achievement-of-therapeutic-drug-monitoring-targets-in-adult-patients-with-haematological-malignancy
#4
Catherine J Byrne, Jason A Roberts, Brett McWhinney, Jerome P Fennell, Philomena O'Byrne, Evelyn Deasy, Sean Egan, Ronan Desmond, Helen Enright, Sheila A Ryder, Deirdre M D'Arcy, Johnny McHugh
Objectives: To explore the following aspects of teicoplanin use in patients with haematological malignancy: early attainment of target trough concentrations with current high dose teicoplanin regimens; variability in unbound teicoplanin fractions; factors associated with observed total and unbound trough concentrations; efficacy and toxicity; and renal function estimation.Methods: This was a single-centre, prospective study. Trough samples were taken on Days 3, 4, 7 and 10. Total and unbound teicoplanin concentrations were determined using validated HPLC methods...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28320178/profile-of-von-willebrand-factor-antigen-and-von-willebrand-factor-propeptide-in-an-overall-tia-and-ischaemic-stroke-population-and-amongst-subtypes
#5
W O Tobin, J A Kinsella, G F Kavanagh, J S O'Donnell, R T McGrath, S Tierney, B Egan, T M Feeley, T Coughlan, D R Collins, D O'Neill, Sjx Murphy, S J Lim, R P Murphy, Djh McCabe
INTRODUCTION: Von Willebrand factor propeptide (VWF:Ag II) is proposed to be a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). Simultaneous data on VWF:Ag and VWF:Ag II profiles are very limited following TIA and ischaemic stroke. METHODS: In this prospective, observational, case-control study, plasma VWF:Ag and VWF:Ag II levels were quantified in 164 patients≤4weeks of TIA or ischaemic stroke (baseline), and then ≥14days (14d) and ≥90days (90d) later, and compared with those from 27 healthy controls...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28318888/characterization-of-the-lung-parenchyma-using-ultrasound-multiple-scattering
#6
Kaustav Mohanty, John Blackwell, Thomas Egan, Marie Muller
The purpose of the study described here was to showcase the application of ultrasound to quantitative characterization of the micro-architecture of the lung parenchyma to predict the extent of pulmonary edema. The lung parenchyma is a highly complex and diffusive medium for which ultrasound techniques have remained qualitative. The approach presented here is based on ultrasound multiple scattering and exploits the complexity of ultrasound propagation in the lung structure. The experimental setup consisted of a linear transducer array with an 8-MHz central frequency placed in contact with the lung surface...
March 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28317260/comparative-proteomic-analysis-of-trophoblast-cell-models-reveals-their-differential-phenotypes-potential-uses-and-limitations
#7
Paulina B Szklanna, Kieran Wynne, Marie Nolan, Karl Egan, Fionnuala Ní Áinle, Patricia B Maguire
Trophoblastic cell lines are widely used in in vitro studies of placental function as a surrogate for primary trophoblasts. To date, no reference proteomics dataset exists to directly compare the shared and unique characteristics of these cells. Here, we performed comparative proteomic profiling of the BeWo and HTR8/SVneo cell lines using label-free quantitative mass spectrometry. 1557 proteins were identified, which included 338 uniquely attributed to BeWo cells, and a further 304 specifically identified in HTR8/SVneo cells...
March 20, 2017: Proteomics
https://www.readbyqxmd.com/read/28293679/research-conference-summary-from-the-2014-international-task-force-on-atp1a3-related-disorders
#8
Hendrik Rosewich, Matthew T Sweney, Suzanne DeBrosse, Kevin Ess, Laurie Ozelius, Eva Andermann, Frederick Andermann, Gene Andrasco, Alice Belgrade, Allison Brashear, Sharon Ciccodicola, Lynn Egan, Alfred L George, Aga Lewelt, Joshua Magelby, Mario Merida, Tara Newcomb, Vicky Platt, Dominic Poncelin, Sandra Reyna, Masayuki Sasaki, Marcio Sotero de Menezes, Kathleen Sweadner, Louis Viollet, Mary Zupanc, Kenneth Silver, Kathryn Swoboda
OBJECTIVE: ATP1A3-related neurologic disorders encompass a broad range of phenotypes that extend well beyond initial phenotypic criteria associated with alternating hemiplegia of childhood (AHC) and rapid-onset dystonia parkinsonism. METHODS: In 2014, the Alternating Hemiplegia of Childhood Foundation hosted a multidisciplinary workshop intended to address fundamental challenges surrounding the diagnosis and management of individuals with ATP1A3-related disorders...
April 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28289372/improved-quantification-of-cerebral-vein-oxygenation-using-partial-volume-correction
#9
Phillip G D Ward, Audrey P Fan, Parnesh Raniga, David G Barnes, David L Dowe, Amanda C L Ng, Gary F Egan
Purpose: Quantitative susceptibility mapping (QSM) enables cerebral venous characterization and physiological measurements, such as oxygen extraction fraction (OEF). The exquisite sensitivity of QSM to deoxygenated blood makes it possible to image small veins; however partial volume effects must be addressed for accurate quantification. We present a new method, Iterative Cylindrical Fitting (ICF), to estimate voxel-based partial volume effects for susceptibility maps and use it to improve OEF quantification of small veins with diameters between 1...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28285644/effects-of-transdermal-testosterone-gel-or-an-aromatase-inhibitor-on-serum-concentration-and-pulsatility-of-growth-hormone-in-older-men-with-age-related-low-testosterone
#10
Jenny Pena Dias, Johannes D Veldhuis, Olga Carlson, Michelle Shardell, Chee W Chia, Denise Melvin, Josephine M Egan, Shehzad Basaria
Growth hormone is the major regulator of growth and body composition. Pulsatile GH secretion declines exponentially with age. Testosterone replacement is being increasingly offered to older men with age-related low testosterone. Testosterone administration has been shown to stimulate GH secretion. However, little is known about the effect of testosterone aromatization to estradiol on GH pulsatility and its impact on IGF-1 in older men. OBJECTIVE: This randomized controlled proof-of-concept trial investigated the relative effects of testosterone and estradiol on GH pulsatility and IGF-1 in older men with low testosterone...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28282915/implementing-the-bruker-maldi-biotyper-in-the-public-health-laboratory-for-c-botulinum-neurotoxin-detection
#11
Michael J Perry, Dominick A Centurioni, Stephen W Davis, George E Hannett, Kimberlee A Musser, Christina T Egan
Currently, the gold standard method for active botulinum neurotoxin (BoNT) detection is the mouse bioassay (MBA). A Centers for Disease Control and Prevention-developed mass spectrometry (MS)-based assay that detects active BoNT was successfully validated and implemented in a public health laboratory in clinical matrices using the Bruker MALDI-TOF MS (Matrix-assisted laser desorption ionization-time of flight mass spectrometry) Biotyper. For the first time, a direct comparison with the MBA was performed to determine MS-based assay sensitivity using the Bruker MALDI Biotyper...
March 9, 2017: Toxins
https://www.readbyqxmd.com/read/28277509/non-coding-rna-more-uses-for-genomic-junk
#12
Karen Adelman, Emily Egan
No abstract text is available yet for this article.
March 8, 2017: Nature
https://www.readbyqxmd.com/read/28275162/leptin-signalling-in-agrp-neurons-modulates-puberty-onset-and-adult-fertility-in-mice
#13
Olivia K Egan, Megan A Inglis, Greg M Anderson
The hormone leptin indirectly communicates metabolic information to brain neurons that control reproduction, using GABAergic circuitry. Agouti-related peptide (AgRP) neurons in the arcuate nucleus are GABAergic, express leptin receptors (LepR) and are known to influence reproduction. This study tested whether leptin actions on AgRP neurons are required and sufficient for puberty onset and subsequent fertility. Firstly, Agrp-Cre and Lepr-flox mice were used to target deletion of LepR to AgRP neurons. AgRP-LepR knockout female mice exhibited mild obesity and adiposity as previously described, as well as a significant delay in the pubertal onset of estrous cycles compared to control animals...
March 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28275112/clic1-null-mice-demonstrate-a-role-for-clic1-in-macrophage-superoxide-production-and-tissue-injury
#14
Barbara Ulmasov, Jonathan Bruno, Kiyoko Oshima, Yao-Wen Cheng, Stephen P Holly, Leslie V Parise, Terrance M Egan, John C Edwards
We generated and studied CLIC1 null (C1KO) mice to investigate the physiological role of this protein. C1KO and matched wild-type (WT) mice were studied in two models of acute toxic tissue injury. CLIC1 expression is upregulated following acute injury of WT kidney and pancreas and is absent in C1KOs. Acute tissue injury is attenuated in the C1KOs and this correlates with an absence of the rise in tissue reactive oxygen species (ROS) that is seen in WT mice. Infiltration of injured tissue by inflammatory cells was comparable between WT and C1KOs...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28272916/response-to-letter-to-the-editor-regarding-from-dispensed-to-disposed-evaluating-the-effectiveness-of-disposal-programs-through-a-comparison-with-prescription-drug-monitoring-program-data
#15
Kathleen L Egan, Mark Wolfson
No abstract text is available yet for this article.
March 8, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28267636/population-pharmacokinetics-of-teicoplanin-and-attainment-of-pharmacokinetic-pharmacodynamic-targets-in-adult-patients-with-haematological-malignancy
#16
Catherine J Byrne, Jason A Roberts, Brett McWhinney, Sheila A Ryder, Jerome P Fennell, Philomena O'Byrne, Evelyn Deasy, Sean Egan, Ronan Desmond, Helen Enright, Deirdre M D'Arcy, Johnny McHugh
OBJECTIVES: To describe the population pharmacokinetics of teicoplanin in adult haematological malignancy patients receiving higher than standard doses and to perform Monte Carlo simulations to determine dosing regimens associated with optimal teicoplanin concentrations. METHODS: This was a hospital-based clinical trial (EudraCT 2013-004535-72). Nine blood samples were collected on Day 3, plus single trough samples on Days 7 and 10, and 24 and 48 h post last dose...
March 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28261985/commentary-on-daly-egan-2017-intelligence-education-and-addiction
#17
Dorina Cadar, Aradhna Kaushal
No abstract text is available yet for this article.
April 2017: Addiction
https://www.readbyqxmd.com/read/28261147/on-the-role-of-self-compassion-and-self-kindness-in-weight-regulation-and-health-behavior-change
#18
Michail Mantzios, Helen H Egan
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28260177/older-age-at-the-completion-of-linear-growth-is-associated-with-an-increased-risk-of-adult-glioma
#19
Rebecca B Little, L Burt Nabors, Jeffrey J Olson, Zachary J Thompson, Carrie M Rozmeski, Renato V LaRocca, Peter A Forsyth, Reid C Thompson, Robert A Oster, Sajeel A Chowdhary, Kathleen M Egan
PURPOSE: To examine the association of age when adult height was attained with glioma risk. METHODS: We analyzed data from a US-based case-control study of glioma risk factors. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated between age at attainment of adult height and glioma risk. Multivariate models were adjusted for age, race, sex, education, and state of residence. We examined associations overall, and according to glioma grade, sex, and final adult height...
March 4, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28253909/protocol-for-a-systematic-review-with-network-meta-analysis-of-the-modalities-used-to-deliver-ehealth-interventions-for-chronic-pain
#20
Brian W Slattery, Stephanie Haugh, Kady Francis, Laura O'Connor, Katie Barrett, Christopher P Dwyer, Siobhan O'Higgins, Jonathan Egan, Brian E McGuire
BACKGROUND: As eHealth interventions prove both efficacious and practical, and as they arguably overcome certain barriers encountered by traditional face-to-face treatment for chronic pain, their number has increased dramatically in recent times. However, there is a dearth of research that focuses on evaluating and comparing the different types of technology-assisted interventions. This is a protocol for a systematic review that aims to evaluate the eHealth modalities in the context of psychological and non-psychological (other than non-drug) interventions for chronic pain...
March 3, 2017: Systematic Reviews
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