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https://www.readbyqxmd.com/read/28100560/prevalence-impact-and-cost-of-multimorbidity-in-a-cohort-of-people-with-chronic-pain-in-ireland-a-study-protocol
#1
Brian W Slattery, Laura O'Connor, Stephanie Haugh, Christopher P Dwyer, Siobhan O'Higgins, Line Caes, Jonathan Egan, Brian E McGuire
INTRODUCTION: Multimorbidity (MM) refers to the coexistence of two or more chronic conditions within one person, where no one condition is considered primary. As populations age and healthcare provision improves, MM is becoming increasingly common and poses a challenge to the single morbidity approach to illness management, usually adopted by healthcare systems. Indeed, recent research has shown that 66.2% of the people in primary care in Ireland are living with MM. Healthcare usage and cost is significantly associated with MM, and additional chronic conditions lead to exponential increases in service usage and financial costs, and decreases in physical and mental well-being...
January 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28094524/antimalarial-pyrido-1-2-a-benzimidazoles-lead-optimization-parasite-life-cycle-stage-profile-mechanistic-evaluation-killing-kinetics-and-in-vivo-oral-efficacy-in-a-mouse-model
#2
Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette E Botha, Sindisiwe H Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L Coetzer, Jeremy N Burrows, Clive Leonard Yeates, Paolo Denti, Lubbe Wiesner, Timothy J Egan, Sergio Wittlin, Kelly Chibale
Further structure activity relationship (SAR) studies on the recently identified pyrido[1,2-a]benzimidazole (PBI) antimalarials, have led to the identification of potent, metabolically stable compounds with improved in vivo oral efficacy in the P. berghei mouse model and additional activity against parasite liver and gametocyte stages, making them potential candidates for preclinical development. Inhibition of haemozoin formation possibly contributes to the mechanism of action.
January 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28076839/chemotherapy-can-induce-weight-normalization-of-morbidly-obese-mice-despite-undiminished-ingestion-of-high-fat-diet
#3
Cheryl E Myers, Dominique B Hoelzinger, Tiffany N Truong, Lindsey A Chew, Arpita Myles, Leena Chaudhuri, Jan B Egan, Jun Liu, Sandra J Gendler, Peter A Cohen
Morbidly obese patients who accomplish substantial weight loss often display a long-term decline in their resting metabolism, causing even relatively restrained caloric intake to trigger a relapse to the obese state. Paradoxically, we observed that morbidly obese mice receiving chemotherapy for cancer experienced spontaneous weight reduction despite unabated ingestion of their high fat diet (HFD). This response to chemotherapy could also be achieved in morbidly obese mice without cancer. Optimally dosed methotrexate (MTX) or cyclophosphamide (CY) enabled the mice to completely and safely normalize their body weight despite continued consumption of obesogenic quantities of HFD...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28068554/movement-integration-in-elementary-classrooms-teacher-perceptions-and-implications-for-program-planning
#4
Collin A Webster, Nicole Zarrett, Brittany S Cook, Cate Egan, Danielle Nesbitt, R Glenn Weaver
Movement integration (MI), which involves infusing physical activity (PA) into regular classroom time in schools, is widely recommended to help children meet the national guideline of 60min of PA each day. Understanding the perspective of elementary classroom teachers (ECTs) toward MI is critical to program planning for interventions/professional development. This study examined the MI perceptions of ECTs in order to inform the design and implementation of a school-based pilot program that focused in part on increasing children's PA through MI...
December 24, 2016: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28057415/comprehensive-genomic-analysis-of-metastatic-mucinous-urethral-adenocarcinoma-guides-precision-oncology-treatment-targetable-egfr-amplification-leading-to-successful-treatment-with-erlotinib
#5
Alan H Bryce, Mitesh J Borad, Jan B Egan, Rachel M Condjella, Winnie S Liang, Rafael Fonseca, Ann E McCullough, Katherine S Hunt, Nicole R Ritacca, Michael T Barrett, Maitray D Patel, Scott W Young, Alvin C Silva, Thai H Ho, Thorvardur R Halfdanarson, Melissa L Stanton, John Cheville, Scott Swanson, Daniel E Schneider, Robert R McWilliams, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Cuyugan, Jacquelyn McDonald, Jonathan Adkins, Stephen D Mastrian, Daniel D Von Hoff, David W Craig, A Keith Stewart, John D Carpten
No abstract text is available yet for this article.
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28055282/amerindian-but-not-african-or-european-ancestry-is-significantly-associated-with-diurnal-preference-within-an-admixed-brazilian-population
#6
Kieren J Egan, Hadassa Campos Santos, Felipe Beijamini, Núbia E Duarte, Andréa R V R Horimoto, Tâmara P Taporoski, Homero Vallada, André B Negrão, José E Krieger, Mário Pedrazzoli, Kristen L Knutson, Alexandre C Pereira, Malcolm von Schantz
Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness-eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals...
January 5, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28043932/changes-in-presentation-of-celiac-disease-in-ireland-from-the-1960s-to-2015
#7
P Dominguez Castro, G Harkin, M Hussey, B Christopher, C Kiat, J Liong Chin, V Trimble, D McNamara, P MacMathuna, B Egan, B Ryan, D Kevans, R Farrell, V Byrnes, N Mahmud, R McManus
BACKGROUND & AIMS: Celiac disease is an immune-mediated enteropathy characterized with high heterogeneity in presentation among genetically predisposed individuals. In recent years, a change in the phenotypic presentation of celiac disease has been reported. We studied clinical presentation, from 1960 through 2015, in Ireland, which has a high incidence of celiac disease. METHODS: We performed a retrospective analysis of medical charts from patients diagnosed with celiac disease at 5 secondary referral centers in Ireland from 1960 through 2015 (n=749; median age, 56 years; age range 18-91 years)...
December 30, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28040832/renal-transplantation-outcomes-following-heart-and-heart-lung-transplantation
#8
L Wong, Y R Chee, D G Healy, J J Egan, D M Sadlier, Y M O'Meara
BACKGROUND: Chronic kidney disease is a frequent complication following heart and combined heart-lung transplantation. The aim of this study was to analyse the outcome of a subsequent renal transplant in heart, lung and heart-lung transplantation recipients. METHODS: All heart, lung and heart-lung transplant recipients who received a subsequent renal transplant over a 27-year period in a national heart and lung transplant centre were included in this study. RESULTS: A total of 18 patients who had previously undergone heart (n = 6), lung (n = 7) and heart-lung (n = 5) transplantation received a renal transplant...
December 31, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28032475/sense-of-control-and-adolescents-aggression-the-role-of-aggressive-cues
#9
Xucheng Guo, Vincent Egan, Jianxin Zhang
The misperception of aggressive cues is considered a risk factor for inducing adolescent aggression. Poor coping with life stress is also considered a major influence on aggression. The current study examined the relationship between subjective sense of control and adolescent aggression, considering influences upon the perception of these aggressive cues. In Study 1, 60 participants took part in a 2 (sense of control: high sense of control vs. low sense of control) × 2 (aggressive cue: aggressive vs. neutral) between-subjects contextual experiment...
December 2016: PsyCh Journal
https://www.readbyqxmd.com/read/28026869/the-relationship-between-perfectionism-and-psychopathology-a-meta-analysis
#10
REVIEW
Karina Limburg, Hunna J Watson, Martin S Hagger, Sarah J Egan
OBJECTIVE: The clinical significance of 2 main dimensions of perfectionism (perfectionistic strivings and perfectionistic concerns) was examined via a meta-analysis of studies investigating perfectionism in the psychopathology literature. METHOD: We investigated relationships between psychopathology outcomes (clinical diagnoses of depression, anxiety disorders, obsessive-compulsive disorder, and eating disorders; symptoms of these disorders; and outcomes related to psychopathology, such as deliberate self-harm, suicidal ideation, and general distress) and each perfectionism dimension...
December 27, 2016: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28024825/automated-diabetic-retinopathy-image-assessment-software-diagnostic-accuracy-and-cost-effectiveness-compared-with-human-graders
#11
Adnan Tufail, Caroline Rudisill, Catherine Egan, Venediktos V Kapetanakis, Sebastian Salas-Vega, Christopher G Owen, Aaron Lee, Vern Louw, John Anderson, Gerald Liew, Louis Bolter, Sowmya Srinivas, Muneeswar Nittala, SriniVas Sadda, Paul Taylor, Alicja R Rudnicka
OBJECTIVE: With the increasing prevalence of diabetes, annual screening for diabetic retinopathy (DR) by expert human grading of retinal images is challenging. Automated DR image assessment systems (ARIAS) may provide clinically effective and cost-effective detection of retinopathy. We aimed to determine whether ARIAS can be safely introduced into DR screening pathways to replace human graders. DESIGN: Observational measurement comparison study of human graders following a national screening program for DR versus ARIAS...
December 23, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28017342/will-ex-vivo-lung-perfusion-allow-a-move-towards-daytime-lung-transplantation-surgery
#12
Peter Riddell, Jim J Egan
No abstract text is available yet for this article.
December 21, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28008932/timing-and-quality-of-sleep-in-a-rural-brazilian-family-based-cohort-the-baependi-heart-study
#13
F Beijamini, K L Knutson, G Lorenzi-Filho, K J Egan, T P Taporoski, L K G De Paula, A B Negrão, A R V R Horimoto, N E Duarte, H Vallada, J E Krieger, M Pedrazzoli, A C Pereira, M von Schantz
Sleep is modulated by several factors, including sex, age, and chronotype. It has been hypothesised that contemporary urban populations are under pressure towards shorter sleep duration and poorer sleep quality. Baependi is a small town in Brazil that provides a window of opportunity to study the influence of sleep patterns in a highly admixed rural population with a conservative lifestyle. We evaluated sleep characteristics, excessive daytime sleepiness, and chronotype using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Morningness-Eveningness Questionnaire questionnaires, respectively...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28003660/clinical-implementation-of-integrated-genomic-profiling-in-patients-with-advanced-cancers
#14
Mitesh J Borad, Jan B Egan, Rachel M Condjella, Winnie S Liang, Rafael Fonseca, Nicole R Ritacca, Ann E McCullough, Michael T Barrett, Katherine S Hunt, Mia D Champion, Maitray D Patel, Scott W Young, Alvin C Silva, Thai H Ho, Thorvardur R Halfdanarson, Robert R McWilliams, Konstantinos N Lazaridis, Ramesh K Ramanathan, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Cuyugan, Jacquelyn McDonald, Jonathan Adkins, Stephen D Mastrian, Riccardo Valdez, Dawn E Jaroszewski, Daniel D Von Hoff, David W Craig, A Keith Stewart, John D Carpten, Alan H Bryce
DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amendments (CLIA) compliant setting enables a single assay to provide: therapeutic target prioritisation, novel target discovery/application and comprehensive germline assessment. A prospective study in 35 advanced/refractory cancer patients was conducted using CLIA-compliant IGP...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/28003500/relationship-between-risk-factor-control-and-vascular-events-in-the-sammpris-trial
#15
Tanya N Turan, Azhar Nizam, Michael J Lynn, Brent M Egan, Ngoc-Anh Le, Maria F Lopes-Virella, Kathie L Hermayer, Jamie Harrell, Colin P Derdeyn, David Fiorella, L Scott Janis, Bethany Lane, Jean Montgomery, Marc I Chimowitz
OBJECTIVE: The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. In this prespecified analysis, we aimed to investigate the relationship between risk factor control during follow-up and outcome of patients in the medical arm of SAMMPRIS. METHODS: Data from SAMMPRIS participants in the medical arm (n = 227) were analyzed...
December 21, 2016: Neurology
https://www.readbyqxmd.com/read/28003324/e-cigarettes-and-equity-a-systematic-review-of-differences-in-awareness-and-use-between-sociodemographic-groups
#16
REVIEW
Greg Hartwell, Sian Thomas, Matt Egan, Anna Gilmore, Mark Petticrew
OBJECTIVE: To assess whether electronic cigarette (e-cigarette) awareness, 'ever use' and current use vary significantly between different sociodemographic groups. DESIGN: Systematic review. DATA SOURCES: Published and unpublished reports identified by searching seven electronic databases (PubMed, MEDLINE, Web of Science, EMBASE, Global Health, PsycINFO, CINAHL Plus) and grey literature sources. STUDY SELECTION: Systematic search for and appraisal of cross-sectional or longitudinal studies that assessed e-cigarette awareness, 'ever use' or current use, and included subgroup analysis of 1 or more PROGRESS Plus sociodemographic groups...
December 21, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27995832/importance-of-mental-performance-in-parental-choice-of-food-for-children-aged-4-10-years-a-study-in-four-european-countries
#17
Heather Gage, Bernadette Egan, Peter Williams, Brigitte Brands, Eszter Györei, Juan-Carlos López-Robles, Cristina Campoy, Tamas Decsi, Berthold Koletzko, Monique Raats
OBJECTIVE: Typically, attention focuses on how nutrition affects physical health. The present study investigated the importance that parents attach to the impact of diet on mental performance when choosing food for their child. DESIGN: Questionnaire. SETTING: Four European countries. SUBJECTS: Parents of children aged 4-10 years (n 1574): England (n 397), Germany (n 389), Hungary (n 398) and Spain (n 390). RESULTS: Most parents (80-85 %) considered the effect of food on four elements of mental performance (child's ability to learn, attention, behaviour, mood) to be moderately, very, extremely (v...
December 20, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27994673/antimicrobial-peptide-ll-37-participates-in-the-transcriptional-regulation-of-melanoma-cells
#18
Mindy Muñoz, Madeleine Craske, Patricia Severino, Thais Martins de Lima, Paul Labhart, Roger Chammas, Irineu Tadeu Velasco, Marcel Cerqueira César Machado, Brian Egan, Helder I Nakaya, Fabiano Pinheiro da Silva
Antimicrobial peptides are an ancient family of molecules that emerged millions of years ago and have been strongly conserved during the evolutionary process of living organisms. Recently, our group described that the human antimicrobial peptide LL-37 migrates to the nucleus, raising the possibility that LL-37 could directly modulate transcription under certain conditions. Here, we showed evidence that LL-37 binds to gene promoter regions, and LL-37 gene silencing changed the transcriptional program of melanoma A375 cells genes associated with histone, metabolism, cellular stress, ubiquitination and mitochondria...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27981917/an-observational-study-to-assess-if-automated-diabetic-retinopathy-image-assessment-software-can-replace-one-or-more-steps-of-manual-imaging-grading-and-to-determine-their-cost-effectiveness
#19
Adnan Tufail, Venediktos V Kapetanakis, Sebastian Salas-Vega, Catherine Egan, Caroline Rudisill, Christopher G Owen, Aaron Lee, Vern Louw, John Anderson, Gerald Liew, Louis Bolter, Clare Bailey, SriniVas Sadda, Paul Taylor, Alicja R Rudnicka
BACKGROUND: Diabetic retinopathy screening in England involves labour-intensive manual grading of retinal images. Automated retinal image analysis systems (ARIASs) may offer an alternative to manual grading. OBJECTIVES: To determine the screening performance and cost-effectiveness of ARIASs to replace level 1 human graders or pre-screen with ARIASs in the NHS diabetic eye screening programme (DESP). To examine technical issues associated with implementation. DESIGN: Observational retrospective measurement comparison study with a real-time evaluation of technical issues and a decision-analytic model to evaluate cost-effectiveness...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27979440/introducing-the-red-journal-gray-zone
#20
EDITORIAL
David A Palma, Sue S Yom, Katherine Egan Bennett, June Corry, Anthony L Zietman
No abstract text is available yet for this article.
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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