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https://www.readbyqxmd.com/read/29671662/goal-setting-dynamics-that-facilitate-or-impede-a-client-centered-approach
#1
Dorothy Kessler, Ian Walker, Katrine Sauvé-Schenk, Mary Egan
BACKGROUND: Client-centred goal setting is central to the process of enabling occupation. Yet, there are multiple barriers to incorporating client-centred goal setting in practice. We sought to determine what might facilitate or impede the formation of client-centred goals in a context highly supportive of client-centred goal setting Methods: We used conversational analysis to examine goal-setting conversations that took place during a pilot trial of Occupational Performance Coaching for stroke survivors...
April 19, 2018: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29667440/time-use-and-physical-activity-in-a-specialised-brain-injury-rehabilitation-unit-an-observational-study
#2
Leanne Hassett, Siobhan Wong, Emma Sheaves, Maysaa Daher, Andrew Grady, Cara Egan, Carol Seeto, Talia Hosking, Anne Moseley
OBJECTIVES: To determine what is the use of time and physical activity in people undertaking inpatient rehabilitation in a specialised brain injury unit. To determine participants' level of independence related to the use of time and physical activity. METHODS: Design: Cross-sectional observation study. PARTICIPANTS: Fourteen people [mean (SD) age 40 (15) years] with brain injuries undertaking inpatient rehabilitation. PROCEDURE: Participants were observed every 12 minutes over 5 days (Monday to Friday from 7:30 am until 7:30 pm) using a behaviour mapping tool...
April 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29666129/preventing-emergency-department-ed-visits-and-hospitalisations-of-older-adults-with-cognitive-impairment-compared-with-the-general-senior-population-what-do-we-know-about-avoidable-incidents-results-from-a-scoping-review
#3
Mireille Gagnon-Roy, Benyahia Hami, Mélissa Généreux, Nathalie Veillette, Marie-Josée Sirois, Mary Egan, Véronique Provencher
OBJECTIVES: Older cognitively impaired adults present a higher risk of hospitalisation and mortality following a visit to the emergency department (ED). Better understanding of avoidable incidents is needed to prevent them and the associated ED presentations in community-dwelling adults. This study aimed to synthetise the actual knowledge concerning these incidents leading this population to ED presentation, as well as possible preventive measures to reduce them. DESIGN: A scoping review was performed according to the Arksey and O'Malley framework...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29662472/direct-growth-of-bacteria-in-headspace-vials-allows-for-screening-of-volatiles-by-gas-chromatography-mass-spectrometry
#4
Collin M Timm, Evan P Lloyd, Amanda Egan, Ray Mariner, David Karig
Bacterially produced volatile organic compounds (VOCs) can modify growth patterns of eukaryotic hosts and competing/cohabiting microbes. These compounds have been implicated in skin disorders and attraction of biting pests. Current methods to detect and characterize VOCs from microbial cultures can be laborious and low-throughput, making it difficult to understand the behavior of microbial populations. In this work we present an efficient method employing gas chromatography/mass spectrometry with autosampling to characterize VOC profiles from solid-phase bacterial cultures...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29661402/increasing-the-utility-of-target-controlled-infusions-one-model-to-rule-them-all
#5
EDITORIAL
T G Short, D Campbell, T D Egan
No abstract text is available yet for this article.
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29655921/efomp-policy-statement-16-the-role-and-competences-of-medical-physicists-and-medical-physics-experts-under-2013-59-euratom
#6
Carmel J Caruana, Virginia Tsapaki, John Damilakis, Marco Brambilla, Guadalupe Martín Martín, Asen Dimov, Hilde Bosmans, Gillian Egan, Klaus Bacher, Brendan McClean
On 5 December 2013 the European Council promulgated Directive 2013/59/EURATOM. This Directive is important for Medical Physicists and Medical Physics Experts as it puts the profession on solid foundations and describes it more comprehensively. Much commentary regarding the role and competences has been developed in the context of the European Commission project "European Guidelines on the Medical Physics Expert" published as Radiation Protection Report RP174. The guidelines elaborate on the role and responsibilities under 2013/59/EURATOM in terms of a mission statement and competence profile in the specialty areas of Medical Physics relating to medical radiological services, namely Diagnostic and Interventional Radiology, Radiation Oncology and Nuclear Medicine...
April 11, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29651651/interactions-of-coffee-consumption-and-postmenopausal-hormone-use-in-relation-to-breast-cancer-risk-in-uk-biobank
#7
Lusine Yaghjyan, Shannan Rich, Liang Mao, Volker Mai, Kathleen M Egan
PURPOSE: We investigated the association of coffee consumption with postmenopausal breast cancer risk, overall and by the status of postmenopausal hormone therapy (PMH). METHODS: This study included 126,182 postmenopausal women (2,636 with breast cancer and 123,546 without) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Health Service Central Registers. Information on breast cancer risk factors and coffee consumption was collected at baseline and updated during follow-up...
April 12, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29643510/intra-tumour-diversification-in-colorectal-cancer-at-the-single-cell-level
#8
Sophie F Roerink, Nobuo Sasaki, Henry Lee-Six, Matthew D Young, Ludmil B Alexandrov, Sam Behjati, Thomas J Mitchell, Sebastian Grossmann, Howard Lightfoot, David A Egan, Apollo Pronk, Niels Smakman, Joost van Gorp, Elizabeth Anderson, Stephen J Gamble, Chris Alder, Marc van de Wetering, Peter J Campbell, Michael R Stratton, Hans Clevers
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from three colorectal cancers as well as from adjacent normal intestinal crypts. Colorectal cancer cells showed extensive mutational diversification and carried several times more somatic mutations than normal colorectal cells...
April 11, 2018: Nature
https://www.readbyqxmd.com/read/29642568/irradiation-induced-cardiac-connexin-43-and-mir-21-responses-are-hampered-by-treatment-with-atorvastatin-and-aspirin
#9
Csilla Viczenczova, Branislav Kura, Tamara Egan Benova, Chang Yin, Rakesh C Kukreja, Jan Slezak, Narcis Tribulova, Barbara Szeiffova Bacova
Radiation of the chest during cancer therapy is deleterious to the heart, mostly due to oxidative stress and inflammation related injury. A single sub-lethal dose of irradiation has been shown to result in compensatory up-regulation of the myocardial connexin-43 (Cx43), activation of the protein kinase C (PKC) signaling along with the decline of microRNA (miR)-1 and an increase of miR-21 levels in the left ventricle (LV). We investigated whether drugs with antioxidant, anti-inflammatory or vasodilating properties, such as aspirin, atorvastatin, and sildenafil, may affect myocardial response in the LV and right ventricle (RV) following chest irradiation...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29628312/alt-803-an-il-15-superagonist-in-combination-with-nivolumab-in-patients-with-metastatic-non-small-cell-lung-cancer-a-non-randomised-open-label-phase-1b-trial
#10
John M Wrangle, Vamsidhar Velcheti, Manish R Patel, Elizabeth Garrett-Mayer, Elizabeth G Hill, James G Ravenel, Jeffrey S Miller, Mohammad Farhad, Kate Anderton, Kathryn Lindsey, Michele Taffaro-Neskey, Carol Sherman, Samantha Suriano, Marzena Swiderska-Syn, Amy Sion, Joni Harris, Andie R Edwards, Julie A Rytlewski, Catherine M Sanders, Erik C Yusko, Mark D Robinson, Carsten Krieg, William L Redmond, Jack O Egan, Peter R Rhode, Emily K Jeng, Amy D Rock, Hing C Wong, Mark P Rubinstein
BACKGROUND: Immunotherapy with PD-1 or PD-L1 blockade fails to induce a response in about 80% of patients with unselected non-small cell lung cancer (NSCLC), and many of those who do initially respond then develop resistance to treatment. Agonists that target the shared interleukin-2 (IL-2) and IL-15Rβγ pathway have induced complete and durable responses in some cancers, but no studies have been done to assess the safety or efficacy of these agonists in combination with anti-PD-1 immunotherapy...
April 5, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29625628/advanced-robotic-therapy-integrated-centers-artic-an-international-collaboration-facilitating-the-application-of-rehabilitation-technologies
#11
Hubertus J A van Hedel, Giacomo Severini, Alessandra Scarton, Anne O'Brien, Tamsin Reed, Deborah Gaebler-Spira, Tara Egan, Andreas Meyer-Heim, Judith Graser, Karen Chua, Daniel Zutter, Raoul Schweinfurther, J Carsten Möller, Liliana P Paredes, Alberto Esquenazi, Steffen Berweck, Sebastian Schroeder, Birgit Warken, Anne Chan, Amber Devers, Jakub Petioky, Nam-Jong Paik, Won-Seok Kim, Paolo Bonato, Michael Boninger
BACKGROUND: The application of rehabilitation robots has grown during the last decade. While meta-analyses have shown beneficial effects of robotic interventions for some patient groups, the evidence is less in others. We established the Advanced Robotic Therapy Integrated Centers (ARTIC) network with the goal of advancing the science and clinical practice of rehabilitation robotics. The investigators hope to exploit variations in practice to learn about current clinical application and outcomes...
April 6, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29617654/identification-of-cdc25-as-a-common-therapeutic-target-for-triple-negative-breast-cancer
#12
Jeff C Liu, Letizia Granieri, Mariusz Shrestha, Dong-Yu Wang, Ioulia Vorobieva, Elizabeth A Rubie, Rob Jones, YoungJun Ju, Giovanna Pellecchia, Zhe Jiang, Carlo A Palmerini, Yaacov Ben-David, Sean E Egan, James R Woodgett, Gary D Bader, Alessandro Datti, Eldad Zacksenhaus
CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1, but not RB1-deficient cells, posing the challenge of how to target RB1 loss. In triple-negative breast cancer (TNBC), RB1 and PTEN are frequently inactivated together with TP53. We performed kinome/phosphatase inhibitor screens on primary mouse Rb/p53-, Pten/p53-, and human RB1/PTEN/TP53-deficient TNBC cell lines and identified CDC25 phosphatase as a common target. Pharmacological or genetic inhibition of CDC25 suppressed growth of RB1-deficient TNBC cells that are resistant to combined CDK4/6 plus CDK2 inhibition...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29615144/a-pilot-investigation-of-cognitive-behavioural-therapy-for-clinical-perfectionism-in-obsessive-compulsive-disorder-corrigendum
#13
S K Sadri, R A Anderson, P M McEvoy, R T Kane, S J Egan
No abstract text is available yet for this article.
April 4, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29615137/the-relationship-between-obsessive-compulsive-personality-and-obsessive-compulsive-disorder-treatment-outcomes-predictive-utility-and-clinically-significant-change-corrigendum
#14
S K Sadri, P M McEvoy, S J Egan, R T Kane, C S Rees, A Anderson
No abstract text is available yet for this article.
April 4, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29605590/measurement-of-fat-fraction-in-the-human-thymus-by-localized-nmr-and-three-point-dixon-mri-techniques
#15
Kenneth W Fishbein, Sokratis K Makrogiannis, Vanessa A Lukas, Marilyn Okine, Ramona Ramachandran, Luigi Ferrucci, Josephine M Egan, Chee W Chia, Richard G Spencer
PURPOSE: To develop a protocol to non-invasively measure and map fat fraction, fat/(fat+water), as a function of age in the adult thymus for future studies monitoring the effects of interventions aimed at promoting thymic rejuvenation and preservation of immunity in older adults. MATERIALS AND METHODS: Three-dimensional spoiled gradient echo 3T MRI with 3-point Dixon fat-water separation was performed at full inspiration for thymus conspicuity in 36 volunteers 19 to 56 years old...
March 29, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29590351/laboratory-and-field-evaluation-of-the-entomopathogenic-fungus-beauveria-bassiana-deuteromycotina-hyphomycetes-for-population-management-of-spruce-beetle-dendroctonus-rufipennis-coleoptera-scolytinae-in-felled-trees-and-factors-limiting-pathogen-success
#16
Thomas Seth Davis, Andrew J Mann, Danielle Malesky, Egan Jankowski, Clifford Bradley
An isolate of the entomopathogenic fungus Beauveria bassiana (Bals.) Vuill. (Deuteromycotina: Hyphomycetes) was tested for its ability to reduce survival and reproduction of spruce beetle, Dendroctonus rufipennis (Kirby) (Coleoptera: Scolytinae), under laboratory and field conditions. Conidial suspension applied directly to adults or to filter papers that adults contacted had a median survival time of 3-4 d in laboratory assays and beetles died more rapidly when exposed to conidial suspension than when treated with surfactant solution only...
March 24, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29587626/diversity-and-distribution-of-wolbachia-in-relation-to-geography-host-plant-affiliation-and-life-cycle-of-a-heterogonic-gall-wasp
#17
Hannes Schuler, Scott P Egan, Glen R Hood, Robert W Busbee, Amanda L Driscoe, James R Ott
BACKGROUND: The maternally inherited endosymbiont Wolbachia is widespread in arthropods and nematodes and can play an important role in the ecology and evolution of its host through reproductive manipulation. Here, we survey Wolbachia in Belonocnema treatae, a widely distributed North American cynipid gall forming wasp that exhibits regional host specialization on three species of oaks and alternation of sexually and asexually reproducing generations. We investigated whether patterns of Wolbachia infection and diversity in B...
March 27, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29583070/a-developmental-cascade-perspective-of-pediatric-obesity-conceptual-model-and-scoping-review
#18
Justin D Smith, Kaitlyn N Egan, Zorash Montaño, Spring Dawson-McClure, Danielle E Jake-Schoffman, Madeline Larson, Sara M St George
Considering the vast ongoing challenge of preventing obesity, the time has come to reconceptualize and change the way we study the development of obesity in childhood. The developmental cascade model, which refers to the cumulative consequences and spreading downstream effects of risk and protective factors, offers a longitudinal framework for understanding obesity. This perspective elucidates the way an accumulation of risk factors, across and within biopsychosocial spheres and phases of development, can propel individuals toward obesity...
March 27, 2018: Health Psychology Review
https://www.readbyqxmd.com/read/29579766/how-should-lungs-be-allocated-for-transplant
#19
Thomas M Egan
As lung transplantation became established therapy for end-stage lung disease, there were not nearly enough suitable lungs from brain-dead organ donors to meet the need, leading to a focus on how lungs are allocated for transplant. Originally lungs were allocated by the United Network for Organ Sharing (UNOS) like hearts-by waiting time, first to listed recipients in the organ procurement organization of the donor, then to potential recipients in concentric 500 nautical mile circles. This resulted in long waiting times and increasing waitlist deaths...
April 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29568728/repeatability-of-two-dimensional-chemical-shift-imaging-multivoxel-proton-magnetic-resonance-spectroscopy-for-measuring-human-cerebral-choline-containing-compounds
#20
Basant K Puri, Mary Egan, Fintan Wallis, Philip Jakeman
AIM: To investigate the repeatability of proton magnetic resonance spectroscopy in the in vivo measurement of human cerebral levels of choline-containing compounds (Cho). METHODS: Two consecutive scans were carried out in six healthy resting subjects at a magnetic field strength of 1.5 T. On each occasion, neurospectroscopy data were collected from 64 voxels using the same 2D chemical shift imaging (CSI) sequence. The data were analyzed in the same way, using the same software, to obtain the values for each voxel of the ratio of Cho to creatine...
March 22, 2018: World Journal of Psychiatry
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