keyword
MENU ▼
Read by QxMD icon Read
search

Egans

keyword
https://www.readbyqxmd.com/read/28423702/experience-with-precision-genomics-and-tumor-board-indicates-frequent-target-identification-but-barriers-to-delivery
#1
Alan H Bryce, Jan B Egan, Mitesh J Borad, A Keith Stewart, Grzegorz S Nowakowski, Asher Chanan-Khan, Mrinal M Patnaik, Stephen M Ansell, Michaela S Banck, Steven I Robinson, Aaron S Mansfield, Eric W Klee, Gavin R Oliver, Jennifer B McCormick, Norine E Huneke, Colleen M Tagtow, Robert B Jenkins, Kandelaria M Rumilla, Sarah E Kerr, Jean-Pierre A Kocher, Scott A Beck, Martin E Fernandez-Zapico, Gianrico Farrugia, Konstantinos N Lazaridis, Robert R McWilliams
BACKGROUND: The ability to analyze the genomics of malignancies has opened up new possibilities for off-label targeted therapy in cancers that are refractory to standard therapy. At Mayo Clinic these efforts are organized through the Center for Individualized Medicine (CIM). RESULTS: Prior to GTB, datasets were analyzed and integrated by a team of bioinformaticians and cancer biologists. Therapeutically actionable mutations were identified in 65% (92/141) of the patients tested with 32% (29/92) receiving genomically targeted therapy with FDA approved drugs or in an independent clinical trial with 45% (13/29) responding...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422628/occupational-performance-coaching-for-stroke-survivors-a-pilot-randomized-controlled-trial
#2
Dorothy Kessler, Mary Egan, Claire-Jehanne Dubouloz, Sara McEwen, Fiona P Graham
OBJECTIVE: We examined the feasibility of study procedures and explored the potential efficacy of Occupational Performance Coaching for stroke survivors (OPC-Stroke), an intervention designed to improve participation after stroke. METHOD: In this pilot randomized controlled trial, 21 participants were randomized to receive the intervention or usual care. Recruitment, retention, and outcome completion rates were calculated. Direction of change and effect sizes were examined for the outcomes of participation, goal performance and satisfaction, goal self-efficacy, emotional well-being, and cognition...
May 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28419766/microbial-community-function-in-the-bleaching-disease-of-the-marine-macroalgae-delisea-pulchra
#3
Enrique Zozaya-Valdés, Alexandra J Roth-Schulze, Suhelen Egan, Torsten Thomas
Disease is increasingly viewed as a major factor impacting the health of both natural and cultured populations of marine organisms, including macroalgae. The red macroalga Delisea pulchra suffers from a bleaching disease resulting from host stress and infection by opportunistic bacterial pathogens. However how pathogens cause the disease and how the entire algal-associated community is involved in the process is unclear. Here we perform a metagenomic analysis of microbial communities associated with diseased and healthy D...
April 17, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28409213/a-core-outcome-set-for-studies-evaluating-the-effectiveness-of-prepregnancy-care-for-women-with-pregestational-diabetes
#4
Aoife M Egan, Sander Galjaard, Michael J A Maresh, Mary R Loeken, Angela Napoli, Eleni Anastasiou, Eoin Noctor, Harold W de Valk, Mireille van Poppel, Marie Todd, Valerie Smith, Declan Devane, Fidelma P Dunne
AIMS/HYPOTHESIS: The aim of this study was to develop a core outcome set (COS) for trials and other studies evaluating the effectiveness of prepregnancy care for women with pregestational (pre-existing) diabetes mellitus. METHODS: A systematic literature review was completed to identify all outcomes reported in prior studies in this area. Key stakeholders then prioritised these outcomes using a Delphi study. The list of outcomes included in the final COS were finalised at a face-to-face consensus meeting...
April 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/28407253/treatment-of-tibial-diaphyseal-fractures-following-plateless-tibial-tuberosity-advancement-to-manage-cranial-cruciate-disease
#5
R De Sousa, P Egan, K Parsons, S Butterworth, I Calvo, S Roch, A P Moores
OBJECTIVE: To report diaphyseal fractures of the proximal tibia following tibial tuberosity advancement without plate stabilisation for the management of cranial cruciate ligament rupture in dogs. METHODS: Members of the British Veterinary Orthopaedic Association's online discussion forum were invited to submit revision cases of tibial diaphyseal fracture following tibial tuberosity advancement without plate fixation. Data collected included signalment, surgical revision technique, pre- and postoperative revision radiographic findings, complications and veterinary assessment...
April 13, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28406859/visual-acuity-improvement-when-switching-from-ranibizumab-to-aflibercept-is-not-sustained
#6
Cecilia S Lee, Alisa J Kim, Douglas Baughman, Catherine Egan, Clare Bailey, Robert L Johnston, Salim Natha, Rehna Khan, Christopher Brand, Toks Akerele, Martin McKibbin, Louise Downey, Saher Al-Husainy, Aaron Y Lee, Adnan Tufail
PURPOSE: To assess whether visual benefits exist in switching to aflibercept in patients who have been chronically treated with ranibizumab for neovascular age-related macular degeneration. METHODS: A multicenter, national, electronic medical record database study was performed. Patients undergoing six continuous monthly ranibizumab injections and then switched to continuous aflibercept were matched to those on continuous ranibizumab therapy. Matching was performed in a 2:1 ratio and based on visual acuity 6 months before and at the time of the switch, and the number of previous ranibizumab injections...
April 11, 2017: Retina
https://www.readbyqxmd.com/read/28406351/substance-use-in-undergraduate-students-with-histories-of-attention-deficit-hyperactivity-disorder-adhd-the-role-of-impulsivity
#7
Theresa E Egan, Anne E Dawson, Brian T Wymbs
BACKGROUND: Emerging adulthood (18-25 years old) is regarded as a time of identity exploration that includes a peak in risky behaviors, such as substance use and misuse. Attention-deficit/hyperactivity disorder (ADHD) is also associated with greater levels of risky behaviors, including substance use and misuse; however, there is a lack of research on substance use by emerging adults with ADHD, in particular the potential mechanisms that may facilitate this risk. OBJECTIVES: The present study builds on the existing research regarding the association between ADHD and substance use by examining roles of multiple facets of impulsivity in facilitating this association during emerging adulthood...
April 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28404597/altered-mirna-29-expression-in-type-2-diabetes-influences-glucose-and-lipid-metabolism-in-skeletal-muscle
#8
Julie Massart, Rasmus J O Sjögren, Leonidas S Lundell, Jonathan M Mudry, Niclas Franck, Donal J O'Gorman, Brendan Egan, Juleen R Zierath, Anna Krook
MicroRNAs have emerged as important regulators of glucose and lipid metabolism in several tissues, however, their role in skeletal muscle remains poorly characterized. We determined the effects of the miR-29 family on glucose and lipid metabolism, and insulin responsiveness in skeletal muscle. We provide evidence that miR-29a and miR-29c are increased in skeletal muscle from type 2 diabetic patients and decreased following endurance training in healthy young men and in rats. In primary human skeletal muscle cells, inhibition and overexpression strategies demonstrate that miR-29a and miR-29c regulate glucose uptake and insulin-stimulated glucose metabolism...
April 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28395776/evaluation-of-coloured-materials-in-microfluidic-flow-cells-for-chemiluminescence-detection
#9
Kara B Spilstead, Richard Alexander, Egan H Doeven, Stephen J Haswell, Neil W Barnett, Paul S Francis
Recent advances in the construction of chemiluminescence flow-cells has included high precision milling of channels into a range of different polymer materials, in efforts to maximise the transfer of light from the chemical reaction to the photodetector. However, little is known of the extent that the colour of polymer materials will influence this transfer. This may become increasingly important as chemiluminescence detection zones are integrated with other operations within microfluidic devices or micro total analysis systems (μTAS)...
May 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28394743/a-qualitative-analysis-of-male-eating-disorder-symptoms
#10
Katherine D Arnow, Talya Feldman, Elizabeth Fichtel, Iris Hsiao-Jung Lin, Amber Egan, James Lock, Marcus Westerman, Alison M Darcy
Insights into how males experience eating disorder symptoms early in the course of illness are important to improve detection efforts and may also provide valuable information for treatment. In this qualitative study, 10 adolescent males and 10 matched female patients completed standardized questionnaires and were interviewed. Results indicated that although there were many similarities between the genders, females were more likely to describe the involvement of family systems and males were more likely to describe involvement in sports as being catalysts for their disorders...
April 10, 2017: Eating Disorders
https://www.readbyqxmd.com/read/28390687/overtightening-of-the-syndesmosis-revisited-and-the-effect-of-syndesmotic-malreduction-on-ankle-dorsiflexion
#11
Tyler Gonzalez, Jonathan Egan, Mohammad Ghorbanhoseini, Micah Blais, Aron Lechtig, Brian Velasco, Ara Nazarian, John Y Kwon
BACKGROUND: Ankle syndesmotic injuries are a significant source of morbidity and require anatomic reduction to optimize outcomes. Although a previous study concluded that maximal dorsiflexion during syndesmotic fixation was not required, methodologic weaknesses existed and several studies have demonstrated improved ankle dorsiflexion after removal of syndesmotic screws. The purposes of the current investigation are: (1) To assess the effect of compressive syndesmotic screw fixation on ankle dorsiflexion utilizing a controlled load and instrumentation allowing for precise measurement of motion...
March 25, 2017: Injury
https://www.readbyqxmd.com/read/28390444/the-relationship-between-obsessive-compulsive-personality-and-obsessive-compulsive-disorder-treatment-outcomes-predictive-utility-and-clinically-significant-change
#12
Shalane K Sadri, Peter M McEvoy, Sarah J Egan, Robert T Kane, Clare S Rees, Rebecca A Anderson
BACKGROUND: The evidence regarding whether co-morbid obsessive compulsive personality disorder (OCPD) is associated with treatment outcomes in obsessive compulsive disorder (OCD) is mixed, with some research indicating that OCPD is associated with poorer response, and some showing that it is associated with improved response. AIMS: We sought to explore the role of OCPD diagnosis and the personality domain of conscientiousness on treatment outcomes for exposure and response prevention for OCD...
April 9, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28384443/effect-of-platelet-derived-%C3%AE-thromboglobulins-on-coagulation
#13
Karl Egan, Johanna P van Geffen, Hui Ma, Barry Kevane, Aine Lennon, Seamus Allen, Elaine Neary, Martin Parsons, Patricia Maguire, Kieran Wynne, Richard O' Kennedy, Johan W M Heemskerk, Fionnuala Ní Áinle
BACKGROUND: β-thromboglobulins are derived from the cleavage of the CXC chemokine platelet basic protein and are released in high concentrations by activated platelets. Platelet-derived β-thromboglobulins (βTG) share 70% homology with platelet factor 4 (PF4), another CXC chemokine released by activated platelets. PF4 modulates coagulation by inhibiting heparin-antithrombin interactions, promoting protein C activation, and attenuating the activity of activated protein C. In contrast, the effect of βTG on coagulation is unknown...
March 30, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28382385/neighborhood-determinants-of-mood-and-anxiety-disorders-among-men-who-have-sex-with-men-in-new-york-city
#14
Magdalena Cerdá, Vijay Nandi, Victoria Frye, James E Egan, Andrew Rundle, James W Quinn, Daniel Sheehan, Donald R Hoover, Danielle C Ompad, Hong Van Tieu, Emily Greene, Beryl Koblin
PURPOSE: We examined the relationship between economic, physical, and social characteristics of neighborhoods, where men who have sex with men (MSM) lived and socialized, and symptom scores of depression and generalized anxiety disorder (GAD). METHODS: Participants came from a cross-sectional study of a population-based sample of New York City MSM recruited in 2010-2012 (n = 1126). Archival and survey-based data were obtained on neighborhoods, where the men lived and where they socialized most often...
April 5, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28374981/optimal-timing-for-nasal-fracture-manipulation-is-a-two-week-target-really-necessary-a-single-centre-retrospective-analysis-of-50-patients
#15
V Perkins, A Vijendren, M Egan, D McRae
Nasal bone fractures represent the most common isolated facial fracture and are involved in as many as 50% of facial fractures ((1)) . Its relative prominence in the centre of the face as well as its relatively thin, fragile structures makes it particularly susceptible to injury. Acute management is centred on restoring an aesthetically acceptable external nose with minimal airflow limitation. Conventional UK management typically involves assessment 5-7 days following injury, followed by closed reduction within two weeks, to avoid problems associated with fracture healing and bone remodelling ((2)) ...
April 4, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28367399/stress-related-expectations-about-smoking-cessation-and-future-quit-attempts-and-abstinence-a-prospective-study-in-daily-smokers-who-wish-to-quit
#16
Lise Skrubbeltrang Skov-Ettrup, Kia Kejlskov Egan, Peter Dalum, Janne Schurmann Tolstrup
Smokers who wish to quit may refrain from doing so if they expect to experience more stress after haven given up. We test if stress-related expectations about smoking cessation are associated with quit attempts and abstinence among smokers who are motivated to quit. The study included 1809 daily smokers in Denmark in 2011-2013. Stress-related expectations (do you think you will be more, less or equally stressed as a non-smoker?) were measured at baseline. Quit attempts, 30-day point prevalence abstinence and prolonged abstinence (defined as having been abstinent since baseline), were measured after 3, 8 and 14 months...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28362199/effects-of-lumacaftor-ivacaftor-in-a-pediatric-cohort-homozygous-for-f508del-cftr
#17
Marie E Egan
No abstract text is available yet for this article.
April 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28360499/long-term-safety-and-efficacy-of-human-bone-morphogenetic-protein-hbmp-in-the-treatment-of-resistant-non-unions-and-failed-arthrodesis
#18
Arya Nick Shamie, Hamed Yazdanshenas, Eric Egan Johnson
The bone morphogenetic protein (BMP) has emerged as a suitable alternative to autogenous cancellous bone grafting and despite current knowledge about its mechanism; few studies provide evidence about the long-term safety of BMP. The aim of this investigation is to determine if BMP implantation is a safe and effective agent in a long-term setting for the treatment of patients with resistant non-unions and failed arthrodesis. This study is a retrospective case series study that was conducted on 55 patients who had received BMP...
January 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28349119/a-multinational-study-distinguishing-alzheimer-s-and-healthy-patients-using-cerebrospinal-fluid-tau-a%C3%AE-42-cutoff-with-concordance-to-amyloid-positron-emission-tomography-imaging
#19
Yi Mo, Julie Stromswold, Kimberly Wilson, Daniel Holder, Cyrille Sur, Omar Laterza, Mary J Savage, Arie Struyk, Philip Scheltens, Charlotte E Teunissen, James Burke, S Lance Macaulay, Geir Bråthen, Sigrid Botne Sando, Linda R White, Christy Weiss, Arturo Cowes, Michele M Bush, Ganga DeSilva, David G Darby, Stephanie R Rainey-Smith, Jackie Surls, Eileen Sagini, Michael Tanen, Amy Altman, Johan Luthman, Michael F Egan
INTRODUCTION: Changes in cerebrospinal fluid (CSF) tau and amyloid β (Aβ)42 accompany development of Alzheimer's brain pathology. Robust tau and Aβ42 immunoassays were developed to establish a tau/Aβ42 cutoff distinguishing mild-to-moderate Alzheimer's disease (AD) subjects from healthy elderly control (HC) subjects. METHODS: A CSF tau/Aβ42 cutoff criteria was chosen, which distinguished the groups and maximized concordance with amyloid PET. Performance was assessed using an independent validation cohort...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28338530/pharmacologic-characterizations-of-a-p2x7-receptor-specific-radioligand-11c-gsk1482160-for-neuroinflammatory-response
#20
Junbin Han, Hui Liu, Chunling Liu, Hongjun Jin, Joel S Perlmutter, Terrance M Egan, Zhude Tu
OBJECTIVE: The P2X7 receptor (P2X7R) is a key regulatory element in the neuroinflammatory cascade that provides a promising target for imaging neuroinflammation. GSK1482160, a P2X7R modulator with nanomolar binding affinity and high selectivity, has been successfully radiolabeled and utilized for imaging P2X7 levels in a mouse model of lipopolysaccharide-induced systemic inflammation. In the current study, we further characterized its binding profile and determined whether [C]GSK1482160 can detect changes in P2X7R expression in a rodent model of multiple sclerosis...
May 2017: Nuclear Medicine Communications
keyword
keyword
116209
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"