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https://www.readbyqxmd.com/read/27909817/phylogenetic-structure-of-arbuscular-mycorrhizal-fungal-communities-along-an-elevation-gradient
#1
Cameron P Egan, Ragan M Callaway, Miranda M Hart, Jason Pither, John Klironomos
Despite the importance of arbuscular mycorrhizal (AM) fungi within terrestrial ecosystems, we know little about how natural AM fungal communities are structured. To date, the majority of studies examining AM fungal community diversity have focused on single habitats with similar environmental conditions, with relatively few studies having assessed the diversity of AM fungi over large-scale environmental gradients. In this study, we characterized AM fungal communities in the soil along a high-elevation gradient in the North American Rocky Mountains...
December 1, 2016: Mycorrhiza
https://www.readbyqxmd.com/read/27908540/the-role-of-race-and-ethnicity-in-sleep-circadian-rhythms-and-cardiovascular-health
#2
REVIEW
Kieren J Egan, Kristen L Knutson, Alexandre C Pereira, Malcolm von Schantz
In recent years, strong evidence has emerged suggesting that insufficient duration, quality, and/or timing of sleep are associated with cardiovascular disease (CVD), and various mechanisms for this association have been proposed. Such associations may be related to endophenotypic features of the sleep homeostat and the circadian oscillator, or may be state-like effects of the environment. Here, we review recent literature on sleep, circadian rhythms and CVD with a specific emphasis on differences between racial/ethnic groups...
June 3, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27902527/white-matter-alterations-in-adults-with-probable-developmental-coordination-disorder-an-mri-diffusion-tensor-imaging-study
#3
Jacqueline Williams, Saman R Kashuk, Peter H Wilson, Graham Thorpe, Gary F Egan
Movement skill difficulties in children [or developmental coordination disorder (DCD)] often persist into adulthood (in up to 70% of cases). The suggestion of white matter microstructure alterations in children with DCD raises the question of whether similar alterations are present in adults with probable DCD (pDCD). Twelve adults with pDCD and 11 adults without pDCD underwent diffusion tensor imaging. The results showed that the pDCD group had significantly lower fractional anisotropy in the corticospinal tract and superior longitudinal fasciculus and lower mean diffusivity in the internal capsule and inferior longitudinal fasciculus...
November 29, 2016: Neuroreport
https://www.readbyqxmd.com/read/27901638/atlantic-dip-insulin-therapy-for-women-with-iadpsg-diagnosed-gestational-diabetes-mellitus-does-it-work
#4
D Bogdanet, A M Egan, C Reddin, O Kgosidialwa, B Kirwan, L Carmody, F P Dunne
INTRODUCTION: Approximately 40% of women with gestational diabetes mellitus (GDM) diagnosed using IADPSG criteria require insulin therapy. OBJECTIVE: To assess if the outcomes for women with GDM treated with insulin are comparable to women with normal glucose tolerance (NGT). MATERIALS AND METHODS: This retrospective cohort study included 752 women with insulin-treated GDM and 2496 women with NGT during pregnancy. Maternal and foetal outcomes were examined...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27899366/optical-coherence-tomography-angiography-of-foveal-hypoplasia
#5
Kaivon Pakzad-Vaezi, Pearse Keane, João Nobre Cardoso, Catherine Egan, Adnan Tufail
AIMS: To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. METHODS: In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. RESULTS: Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with poor vision demonstrated high grades of foveal hypoplasia...
November 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27893259/adolescent-conscientiousness-predicts-lower-lifetime-unemployment
#6
Mark Egan, Michael Daly, Liam Delaney, Christopher J Boyce, Alex M Wood
Existing research on Big Five personality and unemployment has relied on personality measures elicited after the respondents had already spent years in the labor market, an experience that could change personality. We clarify the direction of influence by using the British Cohort Study (N = 4,206) to examine whether conscientiousness and other Big Five personality traits at age 16-17 predict unemployment over age 16-42. Our hypothesis that higher conscientiousness in adolescence would predict lower unemployment was supported...
November 28, 2016: Journal of Applied Psychology
https://www.readbyqxmd.com/read/27880832/chronic-low-calorie-sweetener-use-and-risk-of-abdominal-obesity-among-older-adults-a-cohort-study
#7
Chee W Chia, Michelle Shardell, Toshiko Tanaka, David D Liu, Kristofer S Gravenstein, Eleanor M Simonsick, Josephine M Egan, Luigi Ferrucci
INTRODUCTION: Low-calorie sweetener use for weight control has come under increasing scrutiny as obesity, especially abdominal obesity, remain entrenched despite substantial low-calorie sweetener use. We evaluated whether chronic low-calorie sweetener use is a risk factor for abdominal obesity. PARTICIPANTS AND METHODS: We used 8268 anthropometric measurements and 3096 food diary records with detailed information on low-calorie sweetener consumption in all food products, from 1454 participants (741 men, 713 women) in the Baltimore Longitudinal Study of Aging collected from 1984 to 2012 with median follow-up of 10 years (range: 0-28 years)...
2016: PloS One
https://www.readbyqxmd.com/read/27875550/an-alternative-approach-to-chip-seq-normalization-enables-detection-of-genome-wide-changes-in-histone-h3-lysine-27-trimethylation-upon-ezh2-inhibition
#8
Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K Kelly, Charles A Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M Bryant, Marie Classon, Patrick Trojer
Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require modulation of chromatin structure. However, analysis of ChIP-seq data is challenging when the manipulation of a chromatin-modifying enzyme significantly affects global levels of histone post-translational modifications. For example, small molecule inhibition of the methyltransferase EZH2 reduces global levels of histone H3 lysine 27 trimethylation (H3K27me3)...
2016: PloS One
https://www.readbyqxmd.com/read/27869678/correction-griffith-d-m-et-al-novel-improved-synthesis-of-hsp70-inhibitor-pifithrin-%C3%AE-in-vitro-synergy-quantification-of-pifithrin-%C3%AE-combined-with-pt-drugs-in-prostate-and-colorectal-cancer-cells-molecules-2016-21-949
#9
Aoife M McKeon, Alan Egan, Jay Chandanshive, Helena McMahon, Darren M Griffith
n/a.
November 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27865202/compulsive-exercise-as-a-mediator-between-clinical-perfectionism-and-eating-pathology
#10
Sarah J Egan, Kate Bodill, Hunna J Watson, Emily Valentine, Chloe Shu, Martin S Hagger
The aim of this study was to examine whether compulsive exercise mediates the relationship between clinical perfectionism and eating pathology, based on the cognitive behavioral model of compulsive exercise. Participants were 368 adults who participated regularly in sport/exercise and completed online measures of perfectionism, compulsive exercise and eating disorders. In support of the well-established link between perfectionism and eating disorders, clinical perfectionism predicted eating pathology both directly and indirectly mediated by compulsive exercise...
November 10, 2016: Eating Behaviors
https://www.readbyqxmd.com/read/27862967/regulation-of-bacterial-cell-wall-growth
#11
REVIEW
Alexander J F Egan, Robert M Cleverley, Katharina Peters, Richard J Lewis, Waldemar Vollmer
During growth and propagation a bacterial cell enlarges and subsequently divides its peptidoglycan (PG) sacculus, a continuous mesh-like layer that encases the cell membrane to confer mechanical strength and morphological robustness. The mechanism of sacculus growth, how it is regulated, and how it is coordinated with other cellular processes is poorly understood. In this article we will discuss briefly the current knowledge of how cell wall synthesis is regulated, on multiple levels, from both sides of the cytoplasmic membrane...
November 12, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27861911/metabolism-of-ketone-bodies-during-exercise-and-training-physiological-basis-for-exogenous-supplementation
#12
Mark Evans, Karl E Cogan, Brendan Egan
Optimising training and performance through nutrition strategies is central to supporting elite sportspeople, much of which has focussed on manipulating the relative intake of carbohydrate and fat and their contributions as fuels for energy provision. The ketone bodies, namely acetoacetate, acetone, and β-hydroxybutyrate (βHB), are produced in the liver during conditions of reduced carbohydrate availability and serve as an alternative fuel source for peripheral tissues including brain, heart and skeletal muscle...
November 10, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27861450/use-of-venodyne-with-lower-extremity-bp-cuff-to-reduce-perioperative-deep-vein-thrombosis
#13
Rhea Elizabeth Ittoop, Brian Egan
No abstract text is available yet for this article.
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27853983/cancer-information-seeking-among-adult-new-zealanders-a-national-cross-sectional-study
#14
Rosalina Richards, Bronwen McNoe, Ella Iosua, Anthony Reeder, Richard Egan, Louise Marsh, Lindsay Robertson, Brett Maclennan, Anna Dawson, Robin Quigg, Anne-Cathrine Petersen
Organisations seeking to establish themselves as leading cancer information sources for the public need to understand patterns and motivators for information seeking. This study describes cancer information seeking among New Zealanders through a national cross-sectional survey conducted in 2014/15 with a population-based sample of adults (18 years and over). Participants were asked if they had sought information about cancer during the past 12 months, the type of information they sought, what prompted them to look for information and ways of getting information they found helpful...
November 16, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27851626/1992-methylene-blue-in-refractory-septic-shock-losing-our-way-for-the-sake-of-a-map
#15
Cyril Varghese, Erin Demartino, Egan Ashley, Jaclyn Jacobi, Daniels Lisa, Korosh Sharain, Jeremy Clain
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845624/targeting-mutant-ras-in-patient-derived-colorectal-cancer-organoids-by-combinatorial-drug-screening
#16
Carla S Verissimo, René M Overmeer, Bas Ponsioen, Jarno Drost, Sander Mertens, Ingrid Verlaan-Klink, Bastiaan van Gerwen, Marieke van der Ven, Marc van de Wetering, David A Egan, René Bernards, Hans Clevers, Johannes L Bos, Hugo J Snippert
Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and tumor organoids with a CRISPR-introduced oncogenic KRAS mutation. Using this panel, we evaluated RAS pathway inhibitors and drug combinations that are currently in clinical trial for RAS mutant cancers. Presence of mutant RAS correlated strongly with resistance to these targeted therapies...
November 15, 2016: ELife
https://www.readbyqxmd.com/read/27836815/overcoming-perfectionism-protocol-of-a-randomized-controlled-trial-of-an-internet-based-guided-self-help-cognitive-behavioral-therapy-intervention
#17
Radha Kothari, Sarah Egan, Tracey Wade, Gerhard Andersson, Roz Shafran
BACKGROUND: Perfectionism is elevated across, and increases risk for, a range of psychological disorders as well as having a direct negative effect on day-to-day function. A growing body of evidence shows that cognitive behavioral therapy (CBT) reduces perfectionism and psychological disorders, with medium to large effect sizes. Given the increased desire for Web-based interventions to facilitate access to evidence-based therapy, Internet-based CBT self-help interventions for perfectionism have been designed...
November 11, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27832198/evolution-of-fitness-cost-neutral-mutant-pfcrt-conferring-p-falciparum-4-aminoquinoline-drug-resistance-is-accompanied-by-altered-parasite-metabolism-and-digestive-vacuole-physiology
#18
Stanislaw J Gabryszewski, Satish K Dhingra, Jill M Combrinck, Ian A Lewis, Paul S Callaghan, Matthew R Hassett, Amila Siriwardana, Philipp P Henrich, Andrew H Lee, Nina F Gnädig, Lise Musset, Manuel Llinás, Timothy J Egan, Paul D Roepe, David A Fidock
Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significant reductions in the deployment of the 4-aminoquinoline drug chloroquine (CQ), which selected for the mutant pfcrt alleles that halted CQ efficacy decades ago, the parasite pfcrt locus is continuously evolving. This is highlighted by the presence of a highly mutated allele, Cam734 pfcrt, which has acquired the singular ability to confer parasite CQ resistance without an associated fitness cost...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27826478/evaluation-of-migraine-surgery-outcomes-through-social-media
#19
Katie G Egan, Jacqueline S Israel, Rezvaneh Ghasemzadeh, Ahmed M Afifi
BACKGROUND: Social media have been used to study many aspects of health and human behavior. Although social media present a unique opportunity to obtain unsolicited patient-reported outcomes, its use has been limited in plastic and reconstructive surgical procedures, including migraine nerve surgery. The goal of this study was to utilize the most popular social media site, Facebook, to evaluate patients' experience with migraine surgery. METHODS: Six months of data regarding nerve surgery, nerve stimulators, and radiofrequency nerve ablation were collected from posts and comments written by members of 2 Facebook groups...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27826289/pimms-pragmatic-insertional-mutation-mapping-system-laboratory-methodology-a-readily-accessible-tool-for-identification-of-essential-genes-in-streptococcus
#20
Adam M Blanchard, Sharon A Egan, Richard D Emes, Andrew Warry, James A Leigh
The Pragmatic Insertional Mutation Mapping (PIMMS) laboratory protocol was developed alongside various bioinformatics packages (Blanchard et al., 2015) to enable detection of essential and conditionally essential genes in Streptococcus and related bacteria. This extended the methodology commonly used to locate insertional mutations in individual mutants to the analysis of mutations in populations of bacteria. In Streptococcus uberis, a pyogenic Streptococcus associated with intramammary infection and mastitis in ruminants, the mutagen pGhost9:ISS1 was shown to integrate across the entire genome...
2016: Frontiers in Microbiology
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