keyword
MENU ▼
Read by QxMD icon Read
search

Egans

keyword
https://www.readbyqxmd.com/read/28630339/ucp1-deficiency-causes-brown-fat-respiratory-chain-depletion-and-sensitizes-mitochondria-to-calcium-overload-induced-dysfunction
#1
Lawrence Kazak, Edward T Chouchani, Irina G Stavrovskaya, Gina Z Lu, Mark P Jedrychowski, Daniel F Egan, Manju Kumari, Xingxing Kong, Brian K Erickson, John Szpyt, Evan D Rosen, Michael P Murphy, Bruce S Kristal, Steven P Gygi, Bruce M Spiegelman
Brown adipose tissue (BAT) mitochondria exhibit high oxidative capacity and abundant expression of both electron transport chain components and uncoupling protein 1 (UCP1). UCP1 dissipates the mitochondrial proton motive force (Δp) generated by the respiratory chain and increases thermogenesis. Here we find that in mice genetically lacking UCP1, cold-induced activation of metabolism triggers innate immune signaling and markers of cell death in BAT. Moreover, global proteomic analysis reveals that this cascade induced by UCP1 deletion is associated with a dramatic reduction in electron transport chain abundance...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28622872/processes-of-local-alcohol-policy-making-in-england-does-the-theory-of-policy-transfer-provide-useful-insights-into-public-health-decision-making
#2
Lucy Gavens, John Holmes, Penny Buykx, Frank de Vocht, Matt Egan, Daniel Grace, Karen Lock, John D Mooney, Alan Brennan
BACKGROUND AND AIMS: Recent years have seen a rise in new and innovative policies to reduce alcohol consumption and related harm in England, which can be implemented by local, as opposed to national, policy-makers. The aim of this paper is to explore the processes that underpin the adoption of these alcohol policies within local authorities. In particular, it aims to assess whether the concept of policy transfer (i.e. a process through which knowledge about policies in one place is used in the development of policies in another time or place) provides a useful model for understanding local alcohol policy-making...
June 13, 2017: Health & Place
https://www.readbyqxmd.com/read/28618299/is-the-devil-in-the-detail-a-randomised-controlled-trial-of-guided-internet-based-cbt-for-perfectionism
#3
Roz Shafran, Tracey D Wade, Sarah J Egan, Radha Kothari, Hannah Allcott-Watson, Per Carlbring, Alexander Rozental, Gerhard Andersson
An internet guided self-help cognitive-behavioural treatment (ICBT) for perfectionism was recently found to be effective (see this issue). Such studies stand in need of replication. The aim of this study was to report the outcomes and predictors of change when the treatment is delivered in a UK setting. A total of 120 people (Mean = 28.9 years; 79% female) were randomised to receive ICBT or wait-list control over 12 weeks (trial registration: NCT02756871). While there were strong similarities between the current study and its Swedish counterpart, there were also important differences in procedural details...
May 26, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28618078/the-perceptions-of-key-stakeholders-of-the-roles-of-specialist-and-advanced-nursing-and-midwifery-practitioners
#4
Mary Casey, Laserina O'Connor, Emma Nicholson, Rita Smith, Denise O'Brien, Denise O'Leary, Gerard M Fealy, Martin S Mcnamara, Diarmuid Stokes, Claire Egan
AIM: To explore the perceptions of key stakeholders of the roles of specialist and advanced nursing and midwifery practitioners. BACKGROUND: There is evidence that the contribution of these roles to patient care is poorly understood. DESIGN: This research took place over two months in 2015 and is part of a larger study involving a rapid review to inform policy development on the specialist and advanced nursing and midwifery practice in Ireland...
June 15, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28610687/assessing-the-thickness-of-the-vaginal-wall-and-vaginal-mucosa-in-pre-menopausal-versus-post-menopausal-women-by-transabdominal-ultrasound-a-feasibility-study
#5
Adrian Balica, Daniella Wald-Spielman, Katherine Schertz, Susan Egan, Gloria Bachmann
OBJECTIVE: As life expectancy increases, the number of women reporting adverse genito-urinary symptoms (genitourinary syndrome of menopause; GSM) from menopause, including vaginal dryness and sexual pain, also will increase. Current objective measurements of vaginal atrophy such as maturation index require vaginal swabs and are invasive; at present, no minimally invasive measurements exist. The purpose of this study was to assess whether total vaginal wall thickness (TVT) and total vaginal mucosa thickness (TMT) as measured by transabdominal ultrasound could qualify as additional objective markers of vaginal wall thinning which could be related to menopausal status...
August 2017: Maturitas
https://www.readbyqxmd.com/read/28607131/trends-in-prehypertension-and-hypertension-risk-factors-in-us-adults-1999-2012
#6
John N Booth, Jiexiang Li, Lu Zhang, Liwei Chen, Paul Muntner, Brent Egan
Prehypertension is associated with increased risk for hypertension and cardiovascular disease. Data are limited on the temporal changes in the prevalence of prehypertension and risk factors for hypertension and cardiovascular disease among US adults with prehypertension. We analyzed data from 30 958 US adults ≥20 years of age who participated in the National Health and Nutrition Examination Surveys between 1999 and 2012. Using the mean of 3 blood pressure (BP) measurements from a study examination, prehypertension was defined as systolic BP of 120 to 139 mm Hg and diastolic BP <90 mm Hg or diastolic BP of 80 to 89 mm Hg and systolic BP <140 mm Hg among participants not taking antihypertensive medication...
June 12, 2017: Hypertension
https://www.readbyqxmd.com/read/28603575/antimicrobial-fungal-endophytes-from-the-botanical-medicine-goldenseal-hydrastis-canadensis
#7
Joseph M Egan, Amninder Kaur, Huzefa A Raja, Joshua J Kellogg, Nicholas H Oberlies, Nadja B Cech
The potential of fungal endophytes to alter or contribute to plant chemistry and biology has been the topic of a great deal of recent interest. For plants that are used medicinally, it has been proposed that endophytes might play an important role in biological activity. With this study, we sought to identify antimicrobial fungal endophytes from the medicinal plant goldenseal (Hydrastis canadensis L., Ranunculaceae), a plant used in traditional medicine to treat infection. A total of 23 fungal cultures were obtained from surface-sterilized samples of H...
September 2016: Phytochemistry Letters
https://www.readbyqxmd.com/read/28597100/sucrose-induced-plasticity-in-the-basolateral-amygdala-in-a-comfort-feeding-paradigm
#8
Amy E B Packard, Shi Di, Ann E Egan, Sarah M Fourman, Jeffrey G Tasker, Yvonne M Ulrich-Lai
A history of intermittent, limited sucrose intake (LSI) attenuates the hypothalamic-pituitary-adrenocortical (HPA) axis stress response, and neuronal activity in the basolateral amygdala (BLA) is necessary for this HPA-dampening. LSI increases the expression of plasticity-associated genes in the BLA; however, the nature of this plasticity is unknown. As BLA principal neuron activity normally promotes HPA responses, the present study tests the hypothesis that LSI decreases stress-excitatory BLA output by decreasing glutamatergic and/or increasing GABAergic inputs to BLA principal neurons...
June 8, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28593647/diets-and-trophic-guilds-of-small-fishes-from-coastal-marine-habitats-in-western-taiwan
#9
J P Egan, U-S Chew, C-H Kuo, V Villarroel-Diaz, P J Hundt, N G Iwinski, M P Hammer, A M Simons
The diets and trophic guilds of small fishes were examined along marine sandy beaches and in estuaries at depths <1·5 m in western Taiwan, Republic of China. Copepods were the most frequently identified item in fish guts, indicating they are key prey for the fish assemblages studied. Piscivore, crustacivore, detritivore, omnivore, zooplanktivore and terrestrial invertivore trophic guilds were identified. The zooplanktivore guild contained the most fish species. Maximum prey size consumption was positively correlated with standard length (LS ) in seven species and at the assemblage level and negatively correlated with LS in a single detritivorous species...
June 7, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28592326/the-genomic-road-to-invasion-examining-the-similarities-and-differences-in-the-genomes-of-associated-oral-pre-cancer-and-cancer-samples
#10
Henry M Wood, Catherine Daly, Rebecca Chalkley, Burcu Senguven, Lisa Ross, Philip Egan, Preetha Chengot, Jennifer Graham, Neeraj Sethi, Thian K Ong, Kenneth MacLennan, Pamela Rabbitts, Caroline Conway
BACKGROUND: It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver mutations are thought to occur early, but it is not known how many of these are present in pre-invasive lesions. These assumptions need to be tested with the increasing focus on both personalised cancer treatments and early detection methodologies. METHODS: We examined genomic copy number changes in 256 pre-invasive and invasive samples from 69 oral cancer patients...
June 7, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28586713/a-randomized-controlled-trial-of-internet-based-cognitive-behavior-therapy-for-perfectionism-including-an-investigation-of-outcome-predictors
#11
Alexander Rozental, Roz Shafran, Tracey Wade, Sarah Egan, Lise Bergman Nordgren, Per Carlbring, Andreas Landström, Stina Roos, Malin Skoglund, Elisabet Thelander, Linnéa Trosell, Alexander Örtenholm, Gerhard Andersson
Being highly attentive to details can be a positive feature. However, for some individuals, perfectionism can lead to distress and is associated with many psychiatric disorders. Cognitive behavior therapy has been shown to yield many benefits for those experiencing problems with perfectionism, but the access to evidence-based care is limited. The current study investigated the efficacy of guided Internet-based Cognitive Behavior Therapy (ICBT) and predictors of treatment outcome. In total, 156 individuals were included and randomized to an eight-week treatment or wait-list control...
May 26, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28574495/black-patients-sustain-vision-loss-while-white-and-south-asian-patients-gain-vision-following-delamination-or-segmentation-surgery-for-tractional-complications-associated-with-proliferative-diabetic-retinopathy
#12
R Mastropasqua, Y H-L Luo, Y S Cheah, C Egan, J J Lewis, L da Cruz
PurposeThis retrospective comparative case series aims to determine whether patient ethnicity (White versus South Asian versus Black) is related to the outcome of surgical treatment for traction complications of severe proliferative diabetic retinopathy (PDR).SettingMoorfields Eye Hospital London, UK.MethodsAll patients who underwent vitrectomy with, delamination and/or segmentation for PDR over a 5-year period (2009-2014) were reviewed retrospectively. Patients were divided into White, South Asian or Black groups, and their age, gender, HbA1C and type of diabetes were recorded...
June 2, 2017: Eye
https://www.readbyqxmd.com/read/28573815/tape-lift-sampling-of-chemical-threat-agents
#13
Krista Brady, Becky Stilley, Maria Olds, Terry O'Neill, James Egan, Evan Durnal
Commercial-off-the-shelf (COTS) materials were evaluated as surface samplers for the Department of Homeland Security Chemical Forensics Program. The program helps evidence collectors identify trace chemical residues at incident scenes. COTS items are widely available, produced in large lots, and with strict controls. Chemical attribution signatures were collected from common surfaces. Eight tape lift candidates were considered, five were chosen based on performance and tested for analytical interferences and extraction efficiencies with 14 chemicals...
June 2, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28572811/direct-and-pollinator-mediated-effects-of-herbivory-on-strawberry-and-the-potential-for-improved-resistance
#14
Anne Muola, Daniela Weber, Lisa E Malm, Paul A Egan, Robert Glinwood, Amy L Parachnowitsch, Johan A Stenberg
The global decline in pollinators has partly been blamed on pesticides, leading some to propose pesticide-free farming as an option to improve pollination. However, herbivores are likely to be more prevalent in pesticide-free environments, requiring knowledge of their effects on pollinators, and alternative crop protection strategies to mitigate any potential pollination reduction. Strawberry leaf beetles (SLB) Galerucella spp. are important strawberry pests in Northern Europe and Russia. Given that SLB attack both leaf and flower tissue, we hypothesized pollinators would discriminate against SLB-damaged strawberry plants (Fragaria vesca, cultivar 'Rügen'), leading to lower pollination success and yield...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28572610/glp-1-receptor-signalling-promotes-%C3%AE-cell-glucose-metabolism-via-mtor-dependent-hif-1%C3%AE-activation
#15
Rodrigo Carlessi, Younan Chen, Jordan Rowlands, Vinicius F Cruzat, Kevin N Keane, Lauren Egan, Cyril Mamotte, Rebecca Stokes, Jenny E Gunton, Paulo Ivo Homem de Bittencourt, Philip Newsholme
Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires glucose metabolism, we aimed to address the hypothesis that GLP-1 receptor (GLP-1R) signalling can modulate glucose uptake and utilization in β-cells. We have assessed various metabolic parameters after short and long exposure of clonal BRIN-BD11 β-cells and rodent islets to the GLP-1R agonist Exendin-4 (50 nM)...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28572062/the-united-kingdom-diabetic-retinopathy-electronic-medical-record-users-group-report-3-baseline-retinopathy-and-clinical-features-predict-progression-of-diabetic-retinopathy
#16
Cecilia S Lee, Aaron Y Lee, Douglas Baughman, Dawn Sim, Toks Akelere, Christopher Brand, David P Crabb, Alastair K Denniston, Louise Downey, Alan Fitt, Rehna Khan, Sajad Mahmood, Kaveri Mandal, Martin Mckibbin, Geeta Menon, Aires Lobo, B Vineeth Kumar, Salim Natha, Atul Varma, Elizabeth Wilkinson, Danny Mitry, Clare Bailey, Usha Chakravarthy, Adnan Tufail, Catherine Egan
PURPOSE: To determine the time and risk factors for developing proliferative diabetic retinopathy (PDR) and vitreous hemorrhage (VH) DESIGN: Multicenter, national cohort study METHODS: Anonymized data of 50,254 patient eyes with diabetes mellitus at 19 UK hospital eye services were extracted at the initial and follow-up visits between 2007 and 2014. Time to progression of PDR and VH were calculated with Cox regression after stratifying by baseline diabetic retinopathy (DR) severity and adjusting for age, gender, race, and starting visual acuity...
May 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28569919/elevated-plasma-tfpi-activity-causes-attenuated-tf-dependent-thrombin-generation-in-early-onset-preeclampsia
#17
Karl Egan, Hugh O'Connor, Barry Kevane, Fergal Malone, Aine Lennon, Amani Al Zadjali, Sharon Cooley, Cathy Monteith, Patricia Maguire, Paulina Szklanna, Seamus Allen, Naomi McCallion, Fionnuala Ní Áinle
Early onset preeclampsia (EOP) is a pregnancy-specific proinflammatory disorder that is characterised by competing thrombotic and bleeding risks. It was the aim of this study to characterise thrombin generation, a major determinant of thrombotic and bleeding risk, in order to better understand the haemostatic balance in patients with EOP. Patients with EOP were recruited at the Rotunda Hospital, Dublin. Twenty-six cases of EOP were recruited over a 21-month period, out of 15,299 deliveries at the Rotunda. Blood samples were collected into sodium citrate plus corn trypsin inhibitor anticoagulated vacutainers, platelet-poor plasma was prepared, and calibrated automated thrombography was used to assess thrombin generation...
June 1, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28557546/inflammation-associated-dna-methylation-patterns-in-epithelium-of-ulcerative-colitis
#18
Alan Barnicle, Cathal Seoighe, John M Greally, Aaron Golden, Laurence J Egan
Aberrant DNA methylation patterns have been reported in inflamed tissues and may play a role in disease. We studied DNA methylation and gene expression profiles of purified intestinal epithelial cells from ulcerative colitis patients, comparing inflamed and non-inflamed areas of the colon. We identified 577 differentially methylated sites (false discovery rate <0.2) mapping to 210 genes. From gene expression data from the same epithelial cells, we identified 62 differentially expressed genes with increased expression in the presence of inflammation at prostate cancer susceptibility genes PRAC1 and PRAC2...
May 30, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28556242/cerebral-compensation-during-motor-function-in-friedreich-ataxia-the-image-frda-study
#19
Ian H Harding, Louise A Corben, Martin B Delatycki, Monique R Stagnitti, Elsdon Storey, Gary F Egan, Nellie Georgiou-Karistianis
BACKGROUND: Friedreich ataxia is characterized by progressive motor incoordination that is linked to peripheral, spinal, and cerebellar neuropathology. Cerebral abnormalities are also reported in Friedreich ataxia, but their role in disease expression remains unclear. METHODS: In this cross-sectional functional magnetic resonance imaging study, 25 individuals with Friedreich ataxia and 33 healthy controls performed simple (self-paced single-finger) and complex (visually cued multifinger) tapping tasks to respectively gauge basic and attentionally demanding motor behavior...
May 27, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28545396/transcriptomic-resources-for-the-medicinal-legume-mucuna-pruriens-de-novo-transcriptome-assembly-annotation-identification-and-validation-of-est-ssr-markers
#20
N Sathyanarayana, Ranjith Kumar Pittala, Pankaj Kumar Tripathi, Ratan Chopra, Heikham Russiachand Singh, Vikas Belamkar, Pardeep Kumar Bhardwaj, Jeff J Doyle, Ashley N Egan
BACKGROUND: The medicinal legume Mucuna pruriens (L.) DC. has attracted attention worldwide as a source of the anti-Parkinson's drug L-Dopa. It is also a popular green manure cover crop that offers many agronomic benefits including high protein content, nitrogen fixation and soil nutrients. The plant currently lacks genomic resources and there is limited knowledge on gene expression, metabolic pathways, and genetics of secondary metabolite production. Here, we present transcriptomic resources for M...
May 25, 2017: BMC Genomics
keyword
keyword
116209
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"