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https://www.readbyqxmd.com/read/28521650/-why-worry-about-something-you-can-t-control-negotiated-risk-longevity-and-health-behaviours
#1
Rebecca Llewellyn, Wayne Cunningham, Chrystal Jaye, Jessica Young, Richard Egan, Peter Radue
While we know about lay attitudes towards death and dying, we understand little about the ways people estimate their overall personal risk of life-limiting disease and/or death. This study contributes to the limited literature on lay longevity reckonings, with a particular focus on how these reckonings may influence health behaviours. Semi-structured interviews were held with 21 young older adults (54-65 years), addressing the core questions of 'What do you think you will die from, and how long do you expect to live?' Participants indicated their longevity estimation was guided by three key frameworks: family history, environment and lifestyle factors and lived experience...
May 2017: Health (London)
https://www.readbyqxmd.com/read/28514950/lung-function-imaging-methods-in-cystic-fibrosis-pulmonary-disease
#2
REVIEW
Magdalena Kołodziej, Michael J de Veer, Marian Cholewa, Gary F Egan, Bruce R Thompson
Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised information. High Resolution Computed Tomography (HRCT) is a well-established current 'gold standard' method for monitoring lung anatomical changes in Cystic Fibrosis patients. HRCT provides excellent morphological information, however, the X-ray radiation dose can become significant if multiple scans are required to monitor chronic diseases such as cystic fibrosis...
May 17, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28513478/a-gaze-independent-hybrid-bci-based-on-visual-spatial-attention
#3
John M Egan, Gerard M Loughnane, Helen Fletcher, Emma Meade, Edmund C Lalor
OBJECTIVE: Brain-computer interfaces (BCI) use measures of brain activity to convey a user's intent without the need for muscle movement. Hybrid designs, which use multiple measures of brain activity, have been shown to increase the accuracy of BCIs, including those based on EEG signals reflecting covert attention. Our study examined whether incorporating a measure of the P3 response improved the performance of a previously reported attention-based BCI design that incorporates measures of steady-state visual evoked potentials (SSVEP) and alpha band modulations...
May 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28509796/disposition-of-remifentanil-in-obesity-a-new-pharmacokinetic-model-incorporating-the-influence-of-body-mass
#4
Tae Kyun Kim, Shinju Obara, Talmage D Egan, Charles F Minto, Luca LaColla, David R Drover, Jaap Vuyk, Martijn Mertens
BACKGROUND: The influence of obesity on the pharmacokinetic (PK) behavior of remifentanil is incompletely understood. The aim of the current investigation was to develop a new population PK model for remifentanil that would adequately characterize the influence of body weight (among other covariates, e.g., age) on the disposition of remifentanil in the general adult population. We hypothesized that age and various indices of body mass would be important covariates in the new model. METHODS: Nine previously published data sets containing 4,455 blood concentration measurements from 229 subjects were merged...
June 2017: Anesthesiology
https://www.readbyqxmd.com/read/28506127/living-into-death-a-case-for-an-iterative-fortified-and-cross-sector-approach-to-advance-care-planning
#5
Rebecca Llewellyn, Chrystal Jaye, Richard Egan, Wayne Cunningham, Jessica Young, Peter Radue
Advance care planning (ACP) has been framed as best practice for quality palliative care, yet a growing body of literature affirms the need for an early iterative ACP process to begin when people are young and healthy. A significant gap appears to exist in the literature regarding the utility of death conversations outside the end-of-life context. Could 'death conversations' early in life be an effective tool by which doctor and patient can co-construct a more healthful way of life, and realistic relationship with death? And what variables must be taken into account for these conversations to proceed successfully? This paper provides a narrative exploration of the value of death conversations in the clinical context in New Zealand...
May 16, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28500772/a-test-of-genomic-modularity-among-life-history-adaptations-promoting-speciation-with-gene-flow
#6
Gregory J Ragland, Meredith M Doellman, Peter Meyers, Glen R Hood, Scott P Egan, Thomas H Q Powell, Daniel A Hahn, Patrik Nosil, Jeffrey L Feder
Speciation-with-gene-flow may require adaptive divergence of multiple traits to generate strong ecologically based reproductive isolation. Extensive negative pleiotropy or physical linkage of genes in the wrong phase affecting these diverging traits may therefore hinder speciation, while genetic independence or 'modularity' among phenotypic traits may reduce constraints and facilitate divergence. Here, we test whether the genetics underlying two components of diapause life history, initial diapause intensity and diapause termination timing, constrain differentiation between sympatric hawthorn and apple-infesting host races of the fly Rhagoletis pomonella through analysis of 10,256 SNPs measured via Genotyping-By-Sequencing (GBS)...
May 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28494225/what-about-me-the-loss-of-self-through-the-experience-of-traumatic-childbirth
#7
Veronica Byrne, Jonathan Egan, Pádraig Mac Neela, Kiran Sarma
BACKGROUND AND OBJECTIVE: birth trauma has become an increasingly recognised maternal mental health issue and has important implications for both mother and infant. The importance of subjective birth experience in the development of birth trauma has been identified and may mediate the lack of theoretical consistency in this area. The current study aims to explore the subjective experience of birth trauma among first time mothers in Ireland. It aims to separate the potential effects of peripartum depression (PPD) from this in limiting this qualitative investigation to women who reported birth trauma, without PPD...
May 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28489337/quality-of-randomized-controlled-trials-in-eating-disorder-prevention
#8
REVIEW
Hunna J Watson, Erica L Goodman, Nicole B McLagan, Tara Joyce, Elizabeth French, Vivienne Willan, Sarah J Egan
OBJECTIVE: To investigate the quality of randomized controlled trials (RCTs) of eating disorder prevention. METHOD: A systematic literature search was conducted in Medline, PsycINFO, Embase, Scopus, and the Cochrane Collaboration Library to January 2016. Studies were included if they were RCTs that tested an eating disorder prevention program. We identified 96 studies with a total 15,350 participants (91% female, M age = 17 years) and rated quality with the Quality Rating Scale (QRS; Moncrieff et al...
May 10, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28487591/treatment-rates-for-injectable-tiamulin-and-lincomycin-as-an-estimate-of-morbidity-in-a-swine-herd-with-endemic-swine-dysentery
#9
Krysia Walczak, Robert Friendship, Egan Brockoff, Amy Greer, Zvonimir Poljak
Treatment can be used as an indirect measure of morbidity, and treatment records can be used to describe disease patterns in a population. The aim of this study was to describe the rates of treatments with tiamulin and lincomycin by the intramuscular route in cohorts of pigs affected by swine dysentery. Data from treatment records from 19 cohorts of a 1500-head grower-finisher barn were analyzed using Poisson regression to determine factors associated with rates of treatment. Serial interval and reproductive numbers were extracted...
May 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28487425/a-variant-pfcrt-isoform-can-contribute-to-plasmodium-falciparum-resistance-to-the-first-line-partner-drug-piperaquine
#10
Satish K Dhingra, Devasha Redhi, Jill M Combrinck, Tomas Yeo, John Okombo, Philipp P Henrich, Annie N Cowell, Purva Gupta, Matthew L Stegman, Jonathan M Hoke, Roland A Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J Egan, David A Fidock
Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cambodia. Using zinc finger nuclease-based gene editing, we report that addition of the C101F mutation to the chloroquine (CQ) resistance-conferring PfCRT Dd2 isoform common to Asia can confer PPQ resistance to cultured parasites...
May 9, 2017: MBio
https://www.readbyqxmd.com/read/28487377/the-uk-diabetic-retinopathy-electronic-medical-record-uk-dr-emr-users-group-report-2-real-world-data-for-the-impact-of-cataract-surgery-on-diabetic-macular-oedema
#11
Alastair K Denniston, Usha Chakravarthy, Haogang Zhu, Aaron Y Lee, David P Crabb, Adnan Tufail, Clare Bailey, Toks Akerele, Sahar Al-Husainy, Christopher Brand, Louise Downey, Alan Fitt, Rehna Khan, Vineeth Kumar, Aires Lobo, Sajjad Mahmood, Kaveri Mandal, Martin Mckibbin, Geeta Menon, Salim Natha, Jong Min Ong, Marie D Tsaloumas, Atul Varma, Elizabeth Wilkinson, Robert L Johnston, Catherine A Egan
AIM: To assess the rate of 'treatment-requiring diabetic macular oedema (DMO)' in eyes for the two  years before and after cataract surgery. METHODS: Multicentre national diabetic retinopathy (DR) database study with anonymised data extraction across 19 centres from an electronic medical record system. INCLUSION CRITERIA: eyes undergoing cataract surgery in patients with diabetes with no history of DMO prior to study start. The minimum dataset included: age, visual acuity (all time-points), injection episodes, timing of cataract surgery and ETDRS grading of retinopathy and maculopathy...
May 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28484752/doped-%C3%AE-bismuth-oxides-to-investigate-oxygen-ion-transport-as-a-metric-for-condensed-phase-thermite-ignition
#12
Xizheng Wang, Wenbo Zhou, Jeffery B DeLisio, Garth C Egan, Michael R Zachariah
Nanothermites offer high energy density and high burn rates, but are mechanistically only now being understood. One question of interest is how initiation occurs and how the ignition temperature is related to microscopic controlling parameters. In this study, we explored the potential role of oxygen ion transport in Bi2O3 as a controlling mechanism for condensed phase ignition reaction. Seven different doped δ-Bi2O3 were synthesized by aerosol spray pyrolysis. The ignition temperatures of Al/doped Bi2O3, C/doped Bi2O3 and Ta/doped Bi2O3 were measured by temperature-jump/time-of-flight mass spectrometer coupled with a high-speed camera respectively...
May 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28482678/partnerships-for-active-children-in-elementary-schools-outcomes-of-a-2-year-pilot-study-to-increase-physical-activity-during-the-school-day
#13
R Glenn Weaver, Collin A Webster, Cate Egan, Carolina M C Campos, Robert D Michael, Spyridoula Vazou
PURPOSE: To evaluate the impact of the pilot study Partnerships for Active Children in Elementary Schools on the percentage of children achieving the Institute of Medicine guideline of 30 minutes of moderate-to-vigorous physical activity (MVPA) during the school day. DESIGN: Pre/multiple post-quasi-experimental. SETTING: Four elementary schools. PARTICIPANTS: Physical education (n = 3) and classroom teachers (n = 12) and students (n = 229)...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28482181/longitudinal-changes-in-the-fronto-striatal-network-are-associated-with-executive-dysfunction-and-behavioral-dysregulation-in-huntington-s-disease-30-months-image-hd-data
#14
Juan F Domínguez D, Govinda Poudel, Julie C Stout, Marcus Gray, Phyllis Chua, Beth Borowsky, Gary F Egan, Nellie Georgiou-Karistianis
Neuropsychiatric disturbance-particularly executive dysfunction and behavioral dysregulation-is a common feature of Huntington's disease (HD), with implications for functional capacity and quality of life. No study to date has ascertained whether longitudinal change in brain activity is associated with neuropsychiatric deficits in HD. We used a set-response-shifting task together with functional magnetic resonance imaging to investigate 30-month longitudinal blood-oxygen level dependent (BOLD) signal changes in the fronto-striatal attentional control network in premanifest and symptomatic HD (pre-HD and symp-HD, respectively), relative to healthy control participants...
April 15, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28480530/opportunities-for-improving-cardiovascular-health-outcomes-in-adults-younger-than-65%C3%A2-years-with-guideline-recommended-statin-therapy
#15
Sara M Sarasua, Jiexiang Li, German T Hernandez, Keith C Ferdinand, Jonathan N Tobin, Kevin A Fiscella, Daniel W Jones, Angelo Sinopoli, Brent M Egan
The impact of age, race/ethnicity, healthcare insurance, and selected clinical variables on statin-preventable ASCVD were quantified in adults aged 21 to 79 years from National Health and Nutrition Examination Surveys 2007-2012 using the 2013 American College of Cardiology/American Heart Association guideline on the treatment of cholesterol. Among ≈42.4 million statin-eligible, untreated adults, 52.6% were hypertensive and 71% were younger than 65 years. Of ≈232 000 statin-preventable ASCVD events annually, most occur in individuals younger than 65 years, with higher proportions in blacks and Hispanics than whites (73...
May 7, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28461315/genetic-determinants-of-the-pharmacokinetic-variability-of-rifampicin-in-malawian-adults-with-pulmonary-tuberculosis
#16
Derek J Sloan, Andrew D McCallum, Alessandro Schipani, Deirdre Egan, Henry C Mwandumba, Steve A Ward, David Waterhouse, Gertrude Banda, Theresa J Allain, Andrew Owen, Saye H Khoo, Geraint R Davies
Variable exposure to anti-tuberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (AUC) of rifampicin. We evaluated the contribution of Single Nucleotide Polymorphisms (SNPs) in SLCO1B1 and other candidate genes (AADAC, CES-1) to inter-individual pharmacokinetic variability in Malawi. 174 adults with pulmonary TB underwent sampling of plasma rifampicin concentrations at 2- and 6-hours post-dose...
May 1, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28459045/re-engineering-alzheimer-clinical-trials-global-alzheimer-s-platform-network
#17
J Cummings, P Aisen, R Barton, J Bork, R Doody, J Dwyer, J C Egan, H Feldman, D Lappin, L Truyen, S Salloway, R Sperling, G Vradenburg
Alzheimer's disease (AD) drug development is costly, time-consuming, and inefficient. Trial site functions, trial design, and patient recruitment for trials all require improvement. The Global Alzheimer Platform (GAP) was initiated in response to these challenges. Four GAP work streams evolved in the US to address different trial challenges: 1) registry-to-cohort web-based recruitment; 2) clinical trial site activation and site network construction (GAP-NET); 3) adaptive proof-of-concept clinical trial design; and 4) finance and fund raising...
June 2016: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/28458888/diabetic-ketoacidosis-a-challenging-diabetes-phenotype
#18
Cliona Small, Aoife M Egan, El Muntasir Elhadi, Michael W O'Reilly, Aine Cunningham, Francis M Finucane
SUMMARY: We describe three patients presenting with diabetic ketoacidosis secondary to ketosis prone type 2, rather than type 1 diabetes. All patients were treated according to a standard DKA protocol, but were subsequently able to come off insulin therapy while maintaining good glycaemic control. Ketosis-prone type 2 diabetes (KPD) presenting with DKA has not been described previously in Irish patients. The absence of islet autoimmunity and evidence of endogenous beta cell function after resolution of DKA are well-established markers of KPD, but are not readily available in the acute setting...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28455551/erratum-to-older-age-at-the-completion-of-linear-growth-is-associated-with-an-increased-risk-of-adult-glioma
#19
Rebecca B Little, L Burt Nabors, Jeffrey J Olson, Zachary J Thompson, Carrie M Rozmeski, Renato V LaRocca, Peter A Forsyth, Reid C Thompson, Robert A Oster, Sajeel A Chowdhary, Kathleen M Egan
No abstract text is available yet for this article.
April 28, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28440625/antischistosomal-activity-of-pyrido-1-2-a-benzimidazole-derivatives-and-correlation-with-inhibition-of-%C3%AE-hematin-formation
#20
John Okombo, Kawaljit Singh, Godfrey Mayoka, Ferdinand Ndubi, Linley Barnard, Peter M Njogu, Mathew Njoroge, Liezl Gibhard, Christel Brunschwig, Mireille Vargas, Jennifer Keiser, Timothy J Egan, Kelly Chibale
The extensive use of praziquantel against schistosomiasis raises concerns about drug resistance. New therapeutic alternatives targeting critical pathways within the parasite are therefore urgently needed. Hemozoin formation in Schistosoma presents one such target. We assessed the in vitro antischistosomal activity of pyrido[1,2-a]benzimidazoles (PBIs) and investigated correlations with their ability to inhibit β-hematin formation. We further evaluated the in vivo efficacy of representative compounds in experimental mice and conducted pharmacokinetic analysis on the most potent...
May 3, 2017: ACS Infectious Diseases
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