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Cardiomegaly

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https://www.readbyqxmd.com/read/28211974/whole-exome-sequencing-identified-1-base-pair-novel-deletion-in-bcl2-associated-athanogene-3-bag3-gene-associated-with-severe-dilated-cardiomyopathy-dcm-requiring-heart-transplant-in-multiple-family-members
#1
Muhammad Arshad Rafiq, Ayeshah Chaudhry, Melanie Care, Danna A Spears, Chantal F Morel, Robert M Hamilton
Dilated cardiomyopathy (DCM) is characterized by dilation and impaired contraction of the left ventricle or both ventricles. Among hereditary DCM, the genetic causes are heterogeneous, and include mutations encoding cytoskeletal, nucleoskeletal, mitochondrial, and calcium-handling proteins. We report three severely affected males, in a four-generation pedigree, with DCM phenotype who underwent cardiac transplant. Cardiomegaly with marked biventricular dilation and fibrosis were noticeable histopathological findings...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28176173/massive-left-atrial-calcification-a-case-report-and-review-of-the-literature
#2
Saeid Hosseini, Yousef Rezaei, Niloufar Samiei, Anita Sadeghpour, Mohammad Mehdi Peighambari, Carlos A Mestres, Frank W Sellke
Left atrial (LA) calcification is mostly observed in patients with rheumatic mitral valve (MV) diseases who underwent surgical treatment. We report a case of LA calcification in a 69-year-old woman presented with dyspnea and cyanosis. Admission electrocardiogram showed atrial fibrillation and biventricular hypertrophy. Her chest roentgenogram revealed cardiomegaly and a curvilinear whitish shadow in the area of LA. Transthoracic echocardiography revealed severe mitral stenosis and massive LA thrombosis. The patient underwent an emergent surgery, during which the whitish line on chest roentgenogram proved to be a calcified LA inner wall...
February 7, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28150161/diabetes-in-patients-with-acromegaly
#3
REVIEW
A M Hannon, C J Thompson, M Sherlock
Acromegaly is a clinical syndrome which results from growth hormone excess. Uncontrolled acromegaly is associated with cardiovascular mortality, due to an excess of risk factors including diabetes mellitus, hypertension and cardiomegaly. Diabetes mellitus is a frequent complication of acromegaly with a prevalence of 12-37%. This review will provide an overview of a number of aspects of diabetes mellitus and glucose intolerance in acromegaly including the following: 1. Epidemiology and pathophysiology of abnormalities of glucose homeostasis 2...
February 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28140722/fetal-echocardiographic-findings-in-right-pulmonary-artery-to-left-atrium-communication-a-case-report-and-review-of-the-literature
#4
Tetsuya Ide, Takekazu Miyoshi, Taka-Aki Matsuyama, Ken-Ichi Kurosaki, Jun Yoshimatsu
Right pulmonary artery to left atrium communication (RPALA com) is a fatal congenital heart disease with right-to-left shunting. We present a rare case of RPALA com that was prenatally diagnosed and confirmed by autopsy. We focus on some unique echocardiographic findings for prenatal diagnosis of RPALA com by reviewing our case and the literature. Asymmetric cardiomegaly with a pear sign and dilatation of the pulmonary artery might be useful for screening tests. A larger stalk with the pear sign, high-velocity of shunt flow, and absence of a dilated pulmonary vein might support the prenatal diagnosis of RPALA com...
January 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28122721/adverse-metabolic-phenotype-of-female-offspring-exposed-to-preeclampsia-in-utero-a-characterization-of-the-bph-5-mouse-in-postnatal-life
#5
Elizabeth F Sutton, Heinrich E Lob, Jiunn Song, Yunwei Xia, Scott D Butler, Chin-Chi Liu, Leanne M Redman, Jenny L Sones
Preeclampsia (PE) is a devastating disorder of pregnancy that classically presents with maternal hypertension and proteinuria after 20 weeks of gestation. In addition to being a leading cause of maternal and fetal morbidity/mortality, epidemiological and prospective studies have revealed long term consequences for both the mother and baby of preeclamptic pregnancies, including chronic hypertension as well as other cardiovascular diseases and metabolic derangements. To better understand the effect of in utero exposure of PE on offspring, we utilized the BPH/5 mouse, a spontaneous model of the maternal and fetal PE syndrome...
January 25, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28107077/evaluation-of-cardiac-size-in-the-common-kestrel-falco-tinnunculus-based-on-radiographic-measurements
#6
Ali Mirshahi, Mahnaz Shariatzadeh, Jamshid Razmyar, Mohammad Azizzadeh
The common kestrel ( Falco tinnunculus ) is a common raptor found worldwide. To establish reference intervals for cardiac size by radiography, 14 adult common kestrels were evaluated clinically and with radiographs (lateral and ventrodorsal views). The cardiac width, thoracic width, distance between third and fourth ribs, synsacrum width, coracoid width, and distance between clavicle bones were measured on ventrodorsal radiographs. The ratio between cardiac width and the other 5 indices was calculated. Results showed a significant, positive correlation between the cardiac width and thoracic width and between cardiac width and coracoid width...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28105611/huge-mediastinal-liposarcoma-resected-by-clamshell-thoracotomy-a-case-report
#7
Michihito Toda, Nobuhiro Izumi, Takuma Tsukioka, Hiroaki Komatsu, Satoshi Okada, Kantaro Hara, Ryuichi Ito, Toshihiko Shibata, Noritoshi Nishiyama
BACKGROUND: Liposarcoma is the single most common soft tissue sarcoma. Because mediastinal liposarcomas often grow rapidly and frequently recur locally despite adjuvant chemotherapy and radiotherapy, they require complete excision. Therefore, the feasibility of achieving complete surgical excision must be carefully considered. We here report a case of a huge mediastinal liposarcoma resected via clamshell thoracotomy. CASE PRESENTATION: A 64-year-old man presented with dyspnea on effort...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28032647/fetal-hemodynamics-and-adverse-outcome-in-primary-school-aged-children-with-fetal-growth-restriction-a-prospective-longitudinal-study
#8
Noora Korkalainen, Juha Räsänen, Tuula Kaukola, Hanna Kallankari, Mikko Hallman, Kaarin Mäkikallio
INTRODUCTION: Fetal growth restriction is associated with short-term and long-term mortality and morbidity. We hypothesized that adverse outcome in children with fetal growth restriction at primary school age is associated with fetoplacental circulatory abnormalities. MATERIAL AND METHODS: Comprehensive ultrasonographic assessment of fetoplacental hemodynamics was performed in 72 growth-restricted fetuses prenatally, and short-term outcome data were collected. At the median age of 9 years, mortality and morbidity were determined using medical charts and questionnaires...
January 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28003826/pericardial-effusion-due-to-primary-malignant-pericardial-mesothelioma-a-common-finding-but-an-uncommon-cause
#9
Valery Istomin, David S Blondheim, Simcha R Meisel, Aaron Frimerman, Moshe Lapidot, Ronit Rachmilevitch
This case report describes a 37-year-old female who was admitted to our Emergency Department because of shortness of breath. On physical examination, she had dyspnea and tachycardia and blood pressure was 80/50 mmHg with a pulsus paradoxus of 22 mmHg. Neck veins were distended, heart sounds were distant, and dullness was found on both lung bases. Her chest X-ray revealed bilateral pleural effusion and cardiomegaly. On both computed tomography and echocardiography the heart was of normal size and a large pericardial effusion was noted...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27997001/-a-rare-cardiomegaly
#10
Bruno De Piccoli, Marino Cibin, Marta Possamai, Giuseppe Favretto
We present the case of a patient who came to our attention for enlargement of the cardiac silhouette on chest X-ray. Echocardiography showed moderate diastolic overload of both ventricles with enhanced cardiac output without valvular disease or cardiac shunt that could account for this cardiomegaly. A subsequent abdominal echocardiographic exploration showed an angiomatous transformation of the liver due to diffuse lacunar enlargement of hepatic portal vein branches and arterial-venous shunts. Computed tomography and magnetic resonance imaging confirmed the echocardiographic findings...
November 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/27934625/ultrasonographic-findings-in-two-sheep-with-enzootic-calcinosis
#11
U Braun, K Mitchell, S Schramm, S Nogler, J Hatt, A Malbon
This report describes 2 sheep with enzootic calcinosis characterized by abnormal cardiovascular and respiratory findings and ascites causing abdominal distension. Both sheep were anorexic and listless and had increased heart and respiratory rates. Auscultation of the heart revealed a gallop rhythm in sheep 1 and a loud systolic heart murmur in sheep 2. The activities of liver enzymes were severely increased in both sheep. Abdominal ultrasonography showed severe ascites and congestion of the liver and caudal vena cava...
December 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27922974/training-and-validating-a-deep-convolutional-neural-network-for-computer-aided-detection-and-classification-of-abnormalities-on-frontal-chest-radiographs
#12
Mark Cicero, Alexander Bilbily, Errol Colak, Tim Dowdell, Bruce Gray, Kuhan Perampaladas, Joseph Barfett
OBJECTIVES: Convolutional neural networks (CNNs) are a subtype of artificial neural network that have shown strong performance in computer vision tasks including image classification. To date, there has been limited application of CNNs to chest radiographs, the most frequently performed medical imaging study. We hypothesize CNNs can learn to classify frontal chest radiographs according to common findings from a sufficiently large data set. MATERIALS AND METHODS: Our institution's research ethics board approved a single-center retrospective review of 35,038 adult posterior-anterior chest radiographs and final reports performed between 2005 and 2015 (56% men, average age of 56, patient type: 24% inpatient, 39% outpatient, 37% emergency department) with a waiver for informed consent...
December 5, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27902675/infected-congenital-epicardial-cyst-presenting-as-acute-abdomen
#13
Timothy Dribin, Matthew D Files, Erin R Rudzinski, Ron Kaplan, Kimberly P Stone
A previously healthy 3-year-old boy presented to the emergency department with abdominal pain, fever, and emesis. Laboratory and radiologic evaluation for causes of acute abdomen were negative; however, review of the abdominal x-ray demonstrated cardiomegaly with the subsequent diagnosis of pericardial cyst by echocardiogram and computed tomography. The patient underwent surgical decompression and attempted removal of the cystic structure revealing that the cyst originated from the epicardium. His abdominal pain and fever resolved postoperatively and he completed a 3-week course of ceftriaxone for treatment of Propionibacterium acnes infected congenital epicardial cyst...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27896260/a-case-of-prenatally-diagnosed-extrapulmonary-arteriovenous-malformation-associated-with-a-complex-heart-defect
#14
Ba-Da Jeong, Hye-Sung Won, Suah An, Ji Yeon Kim, Mi-Young Lee, Eun Na Kim, Jung-Sun Kim, Chong Jai Kim
Pulmonary arteriovenous malformations are rare vascular anomalies of the lung, only a few cases of which have been diagnosed prenatally. The diagnostic clue for prenatal diagnosis was cardiomegaly with a particularly enlarged left atrium. All previous cases of pulmonary arteriovenous malformations diagnosed prenatally have been reported as an isolated anomaly or in association with simple heart defects. We here describe the first case of a pulmonary arteriovenous malformation with a complex heart defect that was diagnosed prenatally at 21...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27884343/increased-tolerance-to-stress-in-cardiac-expressed-gain-of-function-of-adenosine-triphosphate-sensitive-potassium-channel-subunit-kir6-1
#15
Matthew C Henn, M Burhan Janjua, Haixia Zhang, Evelyn M Kanter, Carol M Makepeace, Richard B Schuessler, Colin G Nichols, Jennifer S Lawton
BACKGROUND: The adenosine triphosphate-sensitive potassium (KATP) channel opener diazoxide (DZX) prevents myocyte volume derangement and reduced contractility secondary to stress. KATP channels are composed of pore-forming (Kir6.1 or Kir6.2) and regulatory (sulfonylurea receptor, SUR1 or SUR2) subunits. Gain of function (GOF) of Kir6.1 subunits has been implicated in cardiac pathology in Cantu syndrome in humans (cardiomegaly, lymphedema, and pericardial effusions). We hypothesized that GOF of Kir6...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27876299/-single-nucleotide-polymorphisms-in-genes-of-endothelin-1-and-receptor-a-associated-to-cardiovascular-in-essential-hypertension
#16
S R Tamiozzo, O C Lassen, J Herrera, P Igarzabal, S Tabares, A Sembaj
INTRODUCTION: The endothelin system, for its vasoconstrictor action, is related to the development of essential hypertension (HTAe). The polymorphism analysis of their genes represents a new approach to the study of this disease. We propose to analyze the interaction between stages of essential hypertension (HTAe) and risk factors with polymorphisms 138ex1 ins/del A gene endothelin-1 (ET-1) and H323H receptor gene A ET-1 (ETRA). PATIENTS AND METHODS: We included 300 patients of both sexes, unrelated, who consecutively attended the clinic hypertension medical service...
November 18, 2016: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/27859306/multiple-giant-coronary-artery-aneurysms-a-rare-cause-of-sudden-cardiac-death
#17
Martin Janík, Petr Hejna, Michaela Ublová, Ivo Šteiner
Multiple giant aneurysms involving the coronary arteries are uncommon and rarely reported. In the presented case, a 63-year-old man with poorly controlled hypertension died suddenly. Gross autopsy examination showed multiple giant thrombus-filled coronary artery aneurysms, atherosclerotic coronary artery disease, and cardiomegaly. Histological sections of the coronary aneurysms showed atherosclerotic changes with both organized and fresh thrombus. Giant coronary aneurysm is defined as a segmental enlargement of a coronary artery with a diameter exceeding 20 mm or more...
November 11, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27847165/bartonella-associated-inflammatory-cardiomyopathy-in-a-dog
#18
R A Santilli, S Battaia, M Perego, M Tursi, E Grego, C Marzufero, P Gianella
A 6-year-old, male, mongrel dog was presented for acute onset of dyspnea and cough. At admission, the dog was cachectic and severely depressed. The electrocardiogram showed a sinus rhythm conducted with left bundle truncular branch block and interrupted by frequent multiform ventricular ectopic beats organized in allorhythmias. Thoracic radiographs revealed a marked cardiomegaly with perihilar edema, whereas transthoracic echocardiography revealed a dilated cardiomyopathy with segmental dyskinesis. Furosemide, enalapril, pimobendan, and mexiletine were prescribed, and a Holter was scheduled after resolution of congestive heart failure...
February 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27835777/inflammatory-and-oxidative-stress-phenotypes-in-transgenic-sickle-cell-mice
#19
Emmanuelle Charrin, Solomon Fiifi Ofori-Acquah, Elie Nader, Sarah Skinner, Philippe Connes, Vincent Pialoux, Philippe Joly, Cyril Martin
The Townes mouse model of homozygous sickle cell disease (SS) has emerged as the major experimental model for studying pathophysiological mechanisms of human sickle cell disease (SCD). We therefore investigated hematological and hemorheological parameters as well as organ-specific inflammatory and oxidative stress molecular profiles in these animals in steady state conditions. Evidences of SCD-related intravascular hemolysis, impaired red blood cell (RBC) deformability, leukocytosis and altered plasma nitric oxide byproducts (NOx) level were found in the SS mice...
November 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27807682/dilated-cardiomyopathy-as-the-only-clinical-manifestation-of-carnitine-transporter-deficiency
#20
Kyriaki Papadopoulou-Legbelou, Maria Gogou, Vaia Dokousli, Maria Eboriadou, Athanasios Evangeliou
The authors present a case of carnitine transporter deficiency, which was unmasked after an episode of respiratory distress resistant to treatment with bronchodilators. Chest radiograph showed cardiomegaly; electrocardiogram showed left ventricular hypertrophy and echocardiography revealed dilated cardiomyopathy. Heart failure therapy was initiated and metabolic screening was requested, as family history was indicative of inborn errors of metabolism. Very low levels of free carnitine and carnitine esters in blood were found and genetic testing confirmed the diagnosis of carnitine transporter deficiency...
November 3, 2016: Indian Journal of Pediatrics
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