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https://www.readbyqxmd.com/read/26676823/unraveling-the-distinctive-features-of-hemorrhagic-and-non-hemorrhagic-snake-venom-metalloproteinases-using-molecular-simulations
#1
Raoni Almeida de Souza, Natalia Díaz, Ronaldo Alves Pinto Nagem, Rafaela Salgado Ferreira, Dimas Suárez
Snake venom metalloproteinases are important toxins that play fundamental roles during envenomation. They share a structurally similar catalytic domain, but with diverse hemorrhagic capabilities. To understand the structural basis for this difference, we build and compare two dynamical models, one for the hemorrhagic atroxlysin-I from Bothrops atrox and the other for the non-hemorraghic leucurolysin-a from Bothrops leucurus. The analysis of the extended molecular dynamics simulations shows some changes in the local structure, flexibility and surface determinants that can contribute to explain the different hemorrhagic activity of the two enzymes...
January 2016: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/24612485/risk-assessment-of-deep-vein-thrombosis-after-acute-stroke-a-prospective-study-using-clinical-factors
#2
MULTICENTER STUDY
Li-Ping Liu, Hua-Guang Zheng, David Z Wang, Yi-Long Wang, Mohammed Hussain, Hai-Xin Sun, An-Xin Wang, Xing-Quan Zhao, Ke-Hui Dong, Chun-Xue Wang, Wen He, Bin Ning, Yong-Jun Wang
AIMS: Deep-vein thrombosis (DVT) represents a serious complication in acute stroke patients with pulmonary embolus (PE) as a potential outcome. Prediction of DVT may help with formulating a proper prevention strategy. To assess of the risk of deep venous thrombosis (DVT) in acute stroke patients, we developed and validated a clinical score in a cohort study. METHODS: Incidence of Deep Venous Thrombosis after Acute Stroke in China (INVENT-China) is a multicenter prospective cohort study...
May 2014: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/24355606/-sudden-onset-of-distal-bullae-and-splinter-hemorraghes
#3
María Castellanos-González, Elena Arranz-Canales, Diego Velasco-Rodríguez, Francisco Vanaclocha-Sebastián
No abstract text is available yet for this article.
June 2014: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/24120257/-treatment-of-hemorraghic-pancreatic-pseudocyst-by-selective-embolization-of-the-splenic-artery
#4
Beatriz Arencibia Pérez, M Aracely Hidalgo Rodriguez, Pilar Elena González de Chavez Rodriguez, Cristina Chocarro Huesa
No abstract text is available yet for this article.
December 2013: Cirugía Española
https://www.readbyqxmd.com/read/23272471/-acute-stroke-management-in-elderly-patients
#5
Laurent Derex
Elderly patients represent 30% of all stroke patients but remain at risk of receiving suboptimal acute care. Admission to a stroke unit rather than to a general ward and early rehabilitation are justified in elderly ischemic and hemorraghic stroke patients. Elderly patients with ischemic stroke should be given aspirin within 48 hours as it reduces mortality and rate of recurrent stroke by a small but significant amount. Age alone should not be a barrier to thrombolysis with intravenous tissue plasminogen activator for acute ischemic stroke as benefit of treatment does not seem to be diminished in elderly patients...
November 2012: La Revue du Praticien
https://www.readbyqxmd.com/read/22863279/implant-removal-of-osteosynthesis-the-dutch-practice-results-of-a-survey
#6
Dagmar Vos, Beate Hanson, Michiel Verhofstad
BACKGROUND: The aim of this survey study was to evaluate the current opinion and practice of trauma and orthopaedic surgeons in the Netherlands in the removal of implants after fracture healing. METHODS: A web-based questionnaire consisting of 44 items was sent to all active members of the Dutch Trauma Society and Dutch Orthopaedic Trauma Society to determine their habits and opinions about implant removal. RESULTS: Though implant removal is not routinely done in the Netherlands, 89% of the Dutch surgeons agreed that implant removal is a good option in case of pain or functional deficits...
2012: Journal of Trauma Management & Outcomes
https://www.readbyqxmd.com/read/21992229/isg15-facilitates-cellular-antiviral-response-to-dengue-and-west-nile-virus-infection-in-vitro
#7
Jianfeng Dai, Wen Pan, Penghua Wang
BACKGROUND: Dengue virus (DENV) and West Nile virus (WNV), close siblings of the Flaviviridae family, are the causative agents of Dengue hemorraghic shock or West Nile meningoencephalitis respectively. Vaccines against these two flaviviruses are currently unavailable. Interferon- Stimulated Gene 15 (ISG15), encoding an ubiquitin-like protein, is significantly induced by type I interferons or viral infections. Its roles in viral infections, however, vary with viruses, being either anti- or pro-viral...
2011: Virology Journal
https://www.readbyqxmd.com/read/21899964/is-an-ovulation-inducing-factor-oif-present-in-the-seminal-plasma-of-rabbits
#8
COMPARATIVE STUDY
M Silva, A Niño, M Guerra, C Letelier, X P Valderrama, G P Adams, M H Ratto
The objectives of this study were (1) to determine the effect of rabbit seminal plasma on LH secretion and ovulation using the llama animal model as an in vivo ovulation bioassay and (2) to determine the effect of llama or rabbit seminal plasma on ovulation induction in the rabbit model. In Experiment 1, llamas with a growing follicle ≥8mm in diameter were assigned randomly to one of three groups (n=5 per group) and given an intramuscular dose of 1mL of: (a) llama seminal plasma, (b) rabbit seminal plasma, or (c) phosphate buffered saline (PBS; negative control)...
September 2011: Animal Reproduction Science
https://www.readbyqxmd.com/read/19317190/evaluation-of-intraosseous-delivery-of-factor-viia-during-hemorraghic-shock-in-the-pig
#9
James K Wright, Robert J Christy, Robert V Tharp, John E Kalns
The purpose of this investigation is to determine if intraosseous infusion (IO) is a suitable method for the delivery of recombinant human factor VIIa (rFVIIa) during hemorrhagic shock. The measures that were used to evaluate IO delivery suitability included: (1) determination of clinically significant local or systemic toxicity and (2) demonstration that systemic blood levels of rFVIIa increased rapidly following administration. Our results indicate that there was no evidence of significant local or systemic toxicity following infusion and that the systemic blood concentration of rFVIIa peaks immediately after the end of infusion...
February 2009: Military Medicine
https://www.readbyqxmd.com/read/17945891/finding-intervention-points-in-the-pathogenesis-of-dengue-viral-infection
#10
Joc C Tay, Philip Tan
We use probabilistic Boolean networks to simulate the pathogenesis of Dengue Hemorraghic Fever (DHF). Based on Chaturvedi's work, the strength of cytokine influences are modeled stochastically as inducement probabilities. We use an aggregated function approach to derive the DHF Infection Model. Two basins of attractors are observed with synchronous updating; the Null Infection cycle attractor shows an expected cross-regulation of Th1 and Th2 cytokines corresponding to the homeostasis of an uninfected person, while the DHF Infection attractor shows the onset of DHF...
2006: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/15495927/-pasteurella-insights-into-the-virulence-determinants-of-a-heterogenous-bacterial-type
#11
REVIEW
Christa Ewers, Antina Lübke-Becker, Lothar H Wieler
Pasteurella (P.) multocida is the causative agent of numerous economically relevant diseases worldwide. These are enzootic bronchopneumonia in cattle and sheep and hemorraghic septicemia in cattle and buffaloes, Rhinitis atrophicans in swine, snuffles in rabbit, and fowl cholera. All disease complexes are associated with certain capsular and somatic antigens. Even as human pathogen P. multocida is of increasing importance, causing wound infections, and even septicemia, meningitis, and endocarditis. Despite extensive research activities including the genome analysis of one fowl cholera isolate in the year 2001 there are a lot of open questions concerning the molecular pathogenic mechanisms...
September 2004: Berliner und Münchener Tierärztliche Wochenschrift
https://www.readbyqxmd.com/read/15460138/-new-form-of-hemorraghic-fever-in-zaire
#12
G Raffier
The purpose of this report is to describe the events that occurred immediately before and during the first weeks of the Ebola virus epicemic in the Democratic Republic of the Congo (formerly Zaire) in September and October 1976. By October 4 Dr Raffier and Dr Ruppol were already on hand at the epicenter of the epicemic in the Equator region about 1000 km from Kinshasa. They had been mandated by the State Health Commissioner to conduct a firsthand assessment of the reportedly disastrous local conditions and to implement emergency measures necessary to reassure the population...
2004: Médecine Tropicale: Revue du Corps de Santé Colonial
https://www.readbyqxmd.com/read/11151214/-posterior-uveal-pseudomelanoma-clinical-differential-diagnosis-at-the-referral-hospital
#13
S Valverde Almohalla, J Martín Rodrigo, H Alvarez Viersou, J L Encinas Martín
PURPOSE: To determine the rate of patients referred with diagnosis of posterior uveal melanoma to a referral hospital for such disease who were excluded for such diagnosis resting on clinical approach. To determine which are the most frequent corrected diagnosis. METHODS: Retrospective review of clinical histories of patients referred to the Department of Ophthalmology of Hospital Universitario Clínica Puerta de Hierro from January 1983 through April 1998 with clinical diagnosis of posterior uveal melanoma...
August 2000: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/10416227/-epidemiology-of-acute-cerebrovascular-disease-in-lleida-from-1996-to-1997-predictive-factors-of-mortality-at-short-and-medium-term
#14
A Jover-Sáenz, J M Porcel-Pérez, M Vives-Soto, M Rubio-Caballero
INTRODUCTION: Given the great clinical relevance of the cerebrovascular disease, the incidence, nosology, vascular risk factors and factors predicting short and medium-term survival after stroke were evaluated in Lleida (Spain). PATIENTS AND METHODS: Five hundred forty-five consecutive patients with an acute stroke admitted to the Hospital Universitario Arnau de Vilanova during the period 1996-1997 were evaluated. A descriptive epidemiological study and a multivariate logistic regression analysis of predictive factors of mortality at 1-month and 1-year after the stroke were made...
May 16, 1999: Revista de Neurologia
https://www.readbyqxmd.com/read/10346994/indoor-mold-and-children-s-health
#15
Etzel, Rylander
Reactive airways disease in children is increasing in many countries around the world. The clinical diagnosis of asthma or reactive airways disease includes a variable airflow and an increased sensitivity in the airways. This condition can develop after an augmented reaction to a specific agent (allergen) and may cause a life-threatening situation within a very short period of exposure. It can also develop after a long-term exposure to irritating agents that cause an inflammation in the airways in the absence of an allergen...
June 1999: Environmental Health Perspectives
https://www.readbyqxmd.com/read/9765032/hantavirus-seropositivity-in-israeli-patients-with-renal-failure
#16
J George, M Patnaik, E Bakshi, Y Levy, A Ben-David, A Ahmed, J B Peter, Y Shoenfeld
The hantavirus is known to cause hemorraghic fever with renal syndrome (HFRS), which is widely spread in Europe and Asia. Several reports have shown an association of hantavirus antibody titers and the occurrence of renal dysfunction. From these observations, it appears that the virus is widely distributed, and different strains prevail in various areas. In the present work we studied 81 patients with end-stage renal-failure under hemodialysis (HD) treatment, 55 with mild to moderate renal failure, and 50 healthy subjects for the presence of antibodies to Hantaan and Puumala viruses...
1998: Viral Immunology
https://www.readbyqxmd.com/read/9561327/association-of-oligodendroglioma-like-cell-proliferation-and-angiomatous-vasculature-coincidence-or-pathogenetically-related-lesions
#17
D S Tews, J E Bohl, E Van Lindert, K Ringel
We report a case of an oligodendroglioma associated with a cavernous angioma. The patient, a 20-year-old man with an 8-year history of epileptic seizures, presented an acute onset of headache, nausea, and vomiting. Computerized tomographic scan and angiogram revealed multiple vascular malformations in both hemispheres including a cystic hemorraghic lesion with a perifocal edema attributing to a mass effect. Repeated puncture of the cyst failed to give improvement of elevated intracranial pressure. At surgery, the cyst and the underlying lesion were excised and found to be oligodendrocyte-rich tissue with malformed vascular tissue...
March 1998: Clinical Neuropathology
https://www.readbyqxmd.com/read/9124023/escherichia-coli-endocarditis-of-a-native-mitral-valve-with-paravalvular-pseudoaneurysm-formation-and-fatal-hemopericardium
#18
L Oosterbosch, F Oei, P Rogiers, M Vaerenberg, R Ranquin, J Nagler
Until recently only few cases have been described of acute infective endocarditis with E. Coli limited to a normal native mitral valve. Furthermore, mechanisms of so called abcess formation and rupture are still uncompletely understood. We report the case of an E. Coli endocarditis developing a rapidly progressive pseudoaneurysm of the mitral annulus. At necropsy diffuse infectious tissue weakening with pseudoaneurysm formation of the mitral ring and dissection into an hemorraghic pericard were seen. The authors further discuss the changing pattern of infectious agents causing acute infective endocarditis of the native mitral valve, transesophageal echocardiographic characteristics of paravalvular cavities and insights in mechanisms of pseudoaneurysm formation and dissection from clinicopathological findings...
1996: Acta Cardiologica
https://www.readbyqxmd.com/read/8731736/-prognosis-and-intensive-care-of-severe-acute-pancreatitis
#19
REVIEW
T Dugernier, P F Laterre, M Reynaert
Severe acute pancreatitis is morphologically characterized by an extensive and prolonged pancreatic and retroperitoneal inflammation with surimposed patchy or generalized areas of necrosis and hemorraghe in the pancreas and surrounding tissues. Clinical hallmarks include the early development of remote organ dysfunctions, notably cardiorespiratory failure and the late emergence of local complications (hemorraghe, acute pseudocyst and, most importantly, infection). The severity of the attack and the outcome of the patient are critically dependent on the presence and the extent of regional necrosis and are closely related to the casual bacterial contamination of these devitalized areas...
March 15, 1996: La Revue du Praticien
https://www.readbyqxmd.com/read/7146582/-effect-of-neonatal-anoxia-on-bilirubin-levels-in-rat-brain
#20
F Mayor
Neonatal anoxia induces a remarkable rise in brain bilirubin levels in the rat. The percentage of rats affected and the bilirubin levels reached are higher between the 3rd and 6th day after the anoxic episode. The accumulation of bilirubin in the brain could reflect the incidence of intracerebral hemorraghes (of different size and localization) caused by anoxia, and can plan an important role in the ethiology of the bilirubin encephalopathy and the neurological damage due to perinatal asphyxia.
1982: Revista Española de Fisiología
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