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https://www.readbyqxmd.com/read/28871582/pyoderma-gangrenosum-after-breast-mastectomy-and-primary-rectus-abdominis-flap-reconstruction
#1
Yasuhiro Suzuki, Kozue Yokoyama, Mayako Terao, Toru Morioka, Banri Tsuda, Naoki Niikura, Takuho Okamura, Eri Yamada, Kotaro Imagawa, Tadashi Akamatsu, Yutaka Tokuda, Nobue Kumaki
Pyoderma gangrenosum is an intractable disease of unknown cause involving recurrent ulcerative lesions on the skin, and may accompany ulcerative colitis, rheumatoid arthritis, leukemia, systemic lupus erythematosus, and other conditions. Here, we report a rare case of pyoderma gangrenosum in the thoracic abdomen following post-mastectomy reconstructive surgery. A 39-year-old presented at the hospital with a complaint of left papilla erosion. Skin biopsy at the site revealed invasive skin cancer, with Paget-like progression in the cancerous nipple and suspected malignancy of skin appendages...
September 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28830573/assessment-of-the-prognostic-role-of-a-94-single-nucleotide-polymorphisms-risk-score-in-early-breast-cancer-in-the-signal-phare-prospective-cohort-no-correlation-with-clinico-pathological-characteristics-and-outcomes
#2
Elsa Curtit, Xavier Pivot, Julie Henriques, Sophie Paget-Bailly, Pierre Fumoleau, Maria Rios, Hervé Bonnefoi, Thomas Bachelot, Patrick Soulié, Christelle Jouannaud, Hugues Bourgeois, Thierry Petit, Isabelle Tennevet, David Assouline, Marie-Christine Mathieu, Jean-Philippe Jacquin, Sandrine Lavau-Denes, Ariane Darut-Jouve, Jean-Marc Ferrero, Carole Tarpin, Christelle Lévy, Valérie Delecroix, Véronique Trillet-Lenoir, Oana Cojocarasu, Jérôme Meunier, Jean-Yves Pierga, Pierre Kerbrat, Céline Faure-Mercier, Hélène Blanché, Mourad Sahbatou, Anne Boland, Delphine Bacq, Céline Besse, Gilles Thomas, Jean-François Deleuze, Iris Pauporté, Gilles Romieu, David G Cox
BACKGROUND: Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effect of the 94 risk alleles can be calculated to measure the global risk of breast cancer. We aimed to test the hypothesis that the 94-SNP-based risk score is associated with clinico-pathological characteristics, breast cancer subtypes and outcomes in early breast cancer...
August 22, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28695812/clinical-and-sonographic-features-of-mammary-paget-s-disease
#3
Yao Wei, Qingli Zhu, Jianchu Li, Yuxin Jiang
Objective To summarize the clinical and sonographic features of mammary Paget's disease (MPD). Methods Totally 34 female patients with pathologically confirmed MPD were retrospectively recruited. According to diagnosis,the clinical data and sonographic findings were reviewed and analyzed. Results Among these 34 patients,7 patients had single MPD; in the remaining 27 patients,16 were accompanied by invasive ductal carcinoma (IDC),7 by ductal carcinoma in situ (DCIS),3 by both IDC and DCIS,and 1 by other pathologic types of carcinoma...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28693610/gata3-is-a-sensitive-marker-for-primary-genital-extramammary-paget-disease-an-immunohistochemical-study-of-72-cases-with-comparison-to-gross-cystic-disease-fluid-protein-15
#4
Ming Zhao, Lixin Zhou, Li Sun, Yan Song, Yunquan Guo, Xun Zhang, Feng Zhao, Peng Wang, Junqiu Yue, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai, Dengfeng Cao
BACKGROUND: GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied. METHODS: Here we investigated immunohistochemical expression of GATA3 in 72 primary genital EMPDs (35 from female, 37 from male; 45 with intraepithelial disease only, 26 with both intraepithelial disease and invasive adenocarcinoma including 14 also metastasis, 1 with metastatic adenocarcinoma only for study)...
July 10, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28662776/an-atypical-presentation-of-paget-s-disease-of-the-breast-without-nipple-involvement-case-report-and-review-of-the-literature
#5
Justine S Broecker, Charles W Sewell, Bahig M Shehata, Bahar Memis, Nazmi V Adsay, Toncred M Styblo
We present a case of a 63 year-old Caucasian female who developed a right breast skin lesion discrete from the nipple that was subsequently diagnosed as Paget's Disease of the breast (PDB). Imaging did not reveal an underlying breast cancer or involvement of the nipple. The patient underwent a segmental mastectomy preserving the nipple and final pathology demonstrated residual Paget's disease of the skin and did not reveal any additional underlying breast carcinoma. To our knowledge, this case represents the first reported diagnosed case of isolated PDB without nipple involvement...
June 10, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28631716/-anogenital-mammary-like-glands-and-related-diseases-part-2-malignant-tumors-of-the-anogenital-glands
#6
A M Konstantinova, I E Belousova, D Kacerovska, M Michal, K V Shelekhova, D V Kazakov
Mammary-like glands are a normal anatomical component of the anogenital region and can give rise to many benign and malignant tumors that morphologically mimic the similar diseases of the breast. The literature review is complemented by a description of 199 cases of malignant tumors of mammary-like glands. The paper presents the clinical and morphological characteristics of various malignant tumors of mammary-like glands, including extramammary Paget's disease, ductal, tubulolobular, adenoid cystic adenocarcinoma, low-grade phyllodes tumor, etc...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28624696/superimposable-outcomes-for-sequential-and-concomitant-administration-of-adjuvant-trastuzumab-in%C3%A2-her2-positive-breast-cancer-results-from-the-signal-phare-prospective-cohort
#7
RANDOMIZED CONTROLLED TRIAL
Xavier Pivot, Pierre Fumoleau, Jean-Yves Pierga, Suzette Delaloge, Hervé Bonnefoi, Thomas Bachelot, Christelle Jouannaud, Hugues Bourgeois, Maria Rios, Patrick Soulié, Jean-Philippe Jacquin, Sandrine Lavau-Denes, Pierre Kerbrat, David Cox, Céline Faure-Mercier, Iris Pauporte, Joseph Gligorov, Elsa Curtit, Julie Henriques, Sophie Paget-Bailly, Gilles Romieu
AIM: Adjuvant clinical trials in early human epidermal growth factor receptor 2 (HER2)-positive breast cancer have assessed either sequential or concomitant incorporation of trastuzumab with chemotherapy; only the North Central Cancer Treatment Group (NCCTG)-N9831 trial prospectively compared both modalities. In routine trastuzumab has been incorporated into a concurrent regimen with taxane chemotherapy instead of sequential modality on the basis of a positive risk-benefit ratio. This present study assessed sequential versus concomitant administration of adjuvant trastuzumab...
August 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28551891/-bisphosphonates-and-ocular-inflammation
#8
Daniel Rappoport, Hana Leiba
Bisphosphonates are a group of drugs used for treatment in several bone diseases such as osteoporosis in women, Paget's disease, hypercalcemia of malignancy, primary malignancies of the bone and metastatic bone disease (breast and prostate carcinoma). Numerous reports in the medical literature described ocular side effects in patients treated with these drugs. We report on two patients, treated with bisphosphonates due to malignancy, who presented with unilateral and bilateral uveitis. Treatment of the ocular inflammation should include local and systemic treatment and stopping the systemic use of bisphosphonates...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551484/a-common-cancer-in-an-uncommon-location-a-case-report-of-squamous-cell-carcinoma-of-the-nipple
#9
Kelly Dye, Melissa Saucedo, Divya Raju, Nail Aydin
INTRODUCTION: Cutaneous squamous cell carcinoma (SCC) is common however SCC is rarely seen on the nipple, with only ten cases of SCC of the nipple in literature (American Cancer Society, 2015; Scotto et al., 1983; Pendse and O'Connor, 2015; Loveland-Jones et al., 2010; Brookes et al., 2005; Sofos et al., 2013; King and Kremer, 2012; Venkataseshan et al., 1994; Hosaka et al., 2011) [1-9]. CASE: An 80 year old female presenting with a chief complaint of an abnormal lesion on the medial portion of her right nipple areola complex...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28541881/paget-disease-of-the-male-breast
#10
S Lopes, J Vide, E Moreira, J Pinheiro, F Azevedo
Paget disease of the breast is an uncommon tumor of the nipple-areola complex that usually presents as an erythematous and erosive lesion. We report the case of a 61-year-old man that presented with a three-year history of an erythematous lesion of the right areola, first treated with topical corticosteroids without benefit. He was then referred to our dermatology department and the clinical suspicion of Paget disease was considered. The diagnosis was later confirmed by biopsy. This case report highlights the importance of clinical recognition of this entity along with other diseases that mimic these skin changes in order to allow earlier diagnosis and proper follow-up...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28422090/surgical-treatment-in-paget-s-disease-with-invasive-ductal-carcinoma-an-observational-study-based-on-seer
#11
Qi Wu, Xiaojun Ding, Juanjuan Li, Si Sun, Shan Zhu, Juan Wu, Qian Liu, Feng Yao, Shengrong Sun
The aim is to analyse the clinical presentation, treatment and outcomes in patients with Paget's disease with invasive ductal carcinoma (PD-IDC), with special emphasis on the role of surgical treatment. Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, we investigated the differences in characteristics, overall survival (OS), and breast cancer-specific mortality (BCSM) between patients with PD-IDC and those with invasive ductal carcinoma (IDC). Compared with IDC group, patients with PD-IDC had a better prognosis and lower mortality in adjusted analyses...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28418164/molecular-subtyping-of-mammary-like-adenocarcinoma-of-the-vulva-shows-molecular-similarity-to-breast-carcinomas
#12
Basile Tessier-Cloutier, Karama Asleh-Aburaya, Varsha Shah, W Glenn McCluggage, Anna Tinker, C Blake Gilks
AIMS: Mammary-like adenocarcinoma (MLA) of the vulva is thought to be derived from vulvar mammary-like glands. The aim of this study was to characterize a series of MLAs by using an immunohistochemical algorithm that identifies the major molecular subtypes of breast cancer. METHODS AND RESULTS: Seven cases of vulval MLA were stained for oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki67, epidermal growth factor receptor (EGFR), cytokeratin (CK) 5, nestin, and inositol polyphosphate-4-phosphatase (INPP4b)...
April 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28395432/-clinicopathological-features-of-acantholytic-mammary-paget-s-disease-a-report-of-28-cases
#13
Y P Zeng, C Chen, K Fang, Q N Jia, D L Ma
Objective: To investigate the clinicopathological features of acantholytic mammary Paget's disease (AMPD). Methods: From January, 2010 to October, 2016, a total of 28 patients were diagnosed as AMPD in the Department of Dermatology, Peking Union Medical College Hospital. The clinical and histopathological data of these patients were analyzed retrospectively. Results: The patients were all female. The mean age of onset was (51±15)years (range, 24 to 78 years). The median course of disease was 10.5 months (range, 3 months to 2 years)...
April 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28329595/pigmented-lesion-of-the-nipple-a-clinicopathological-challenge
#14
Júlia Vide, Artur César, Pedro Rodrigues Pereira, Filomena Azevdo
Differential diagnoses of pigmented lesions of the nipple include melanocytic nevus, melanosis of the nipple, seborrheic keratosis, pigmented basal cell carcinoma, melanoma and Paget disease. The histologic exam with appropriate immunohistochemistry is a fundamental tool to achieve a correct diagnosis. We present a patient with a pigmented lesion of her right nipple revealing mammary Paget disease and elucidate diagnostic obstacles and prognostic importance of early breast cancer detection.
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28316301/paget-s-disease-of-the-breast-an-institutional-review-and-surgical-management
#15
Amelia Y Merrill, Andrew White, Marissa Howard-McNatt
No abstract text is available yet for this article.
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28223083/characteristics-and-prognosis-of-japanese-female-breast-cancer-patients-the-biobank-japan-project
#16
Koshi Nakamura, Emiko Okada, Shigekazu Ukawa, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Yutaka Kiyohara, Kaori Muto, Yoichiro Kamatani, Toshiharu Ninomiya, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. METHODS: Of all Japanese female breast cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry...
March 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28140609/imaging-concordant-benign-mri-guided-vacuum-assisted-breast-biopsy-may-not-warrant-mri-follow-up
#17
Monica L Huang, Megan Speer, Basak E Dogan, Gaiane M Rauch, Rosalind P Candelaria, Beatriz E Adrada, Kenneth R Hess, Wei T Yang
OBJECTIVE: The follow-up of breast lesions with imaging-concordant benign histopathology results on MRI-guided vacuum-assisted biopsy (VAB) is not currently standardized. We determined the false omission rate of breast MRI-guided VAB with benign histopathology (negative results) to assess whether breast MRI follow-up is needed. MATERIALS AND METHODS: The medical records of patients who underwent 9-gauge breast MRI-guided VAB during 2007-2012 were reviewed retrospectively...
April 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28058078/extramammary-paget-s-disease-of-anal-canal-associated-with-rectal-adenoma-without-invasive-carcinoma
#18
Vaibhav Chumbalkar, Timothy A Jennings, Sanaz Ainechi, Edward C Lee, Hwajeong Lee
Extramammary Paget's disease (EMPD) is a rare disease which is found in apocrine-rich locations such as anogenital region, axilla and rarely in other sites. Perianal EMPD is often reported as the involvement of perianal skin, but involvement of anal mucosa is very rare. Based on pathogenesis and association with either synchronous or metachronous malignancy, EMPD can be divided into primary and secondary types. Treatment approach for these two types of Paget's disease and their prognosis is different, thus it is important to make the distinction...
December 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27843872/an-unusual-presentation-of-metastatic-bone-disease-in-a-subject-with-paget-s-disease-of-bone
#19
Shrinath Shetty, Sahana Shetty, Annie Jennifer Prabhu, Nitin Kapoor, Julie Hepzibah, Thomas Vizhalil Paul
Solid organ malignancies involving breast, prostate, and lung frequently metastasize to the skeleton. However, the occurrence of Paget's disease and metastatic bone disease in the same patient is uncommon. We report a case of a 63-year-old man who presented with back pain and a lump in the right breast. He was earlier diagnosed to have Paget's disease of bone based on characteristic skeletal radiological features,(99m)Tc methylene diphosphonate bone scan and elevated alkaline phosphatase, and treated with bisphosphonates, and his disease was in remission...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27769548/characteristics-and-treatment-of-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-43-485-cases-from-the-national-cancer-database-treated-in-2010-and-2011
#20
Brigid K Killelea, Anees B Chagpar, Nina R Horowitz, Donald R Lannin
BACKGROUND: Although identification of human epidermal growth factor receptor 2 (Her2) positive breast cancer represents one of the greatest advances over the past 3 decades, it has not been studied extensively on a national level. METHODS: The National Cancer Database is a joint project of the American Cancer Society and the American College of Surgeons and contains data on about 70% of the cancer cases in the United States. Data on Her2 have been collected since 2010 and was used for this study...
February 2017: American Journal of Surgery
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