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https://www.readbyqxmd.com/read/27779578/does-small-volume-resuscitation-with-crystalloids-or-colloids-influence-hemostasis-and-survival-of-rabbits-subjected-to-lethal-uncontrolled-hemorrhage
#1
Bijan S Kheirabadi, Nahir Miranda, Irasema B Terrazas, Mary D Gonzales, Rose C Grimm, Michael A Dubick
INTRODUCTION: Prehospital, small-volume resuscitation of combat casualties with a synthetic colloid [6% hydroxyethyl starch (HES) 670/0.75] has been recommended when blood or blood components are unavailable. We studied hemostatic effects of a newer synthetic colloid (6% HES 130/0.4,) compared to either a natural colloid (albumin) or to crystalloids in an uncontrolled hemorrhage model. METHODS: Spontaneously breathing NZW rabbits (3.4±0.1 kg) were anesthetized, instrumented and subjected to a splenic injury with uncontrolled bleeding...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27626366/resuscitation-with-pooled-and-pathogen-reduced-plasma-attenuates-the-increase-in-brain-water-content-following-traumatic-brain-injury-and-hemorrhagic-shock-in-rats
#2
Gustav Folmer Genét, Peter Bentzer, Sisse Rye Ostrowski, Pär Ingemar Johansson
Traumatic brain injury and hemorrhagic shock is associated with blood-brain barrier (BBB) breakdown and edema formation. Recent animal studies have shown that fresh frozen plasma (FFP) resuscitation reduces brain swelling and improves endothelial function compared to isotonic NaCl (NS). The aim of this study was to investigate whether pooled and pathogen-reduced plasma (OctaplasLG(®) [OCTA]; Octapharma, Stockholm, Sweden) was comparable to FFP with regard to effects on brain water content, BBB permeability, and plasma biomarkers of endothelial glycocalyx shedding and cell damage...
October 13, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27625478/phenylephrine-infusion-for-spinal-induced-hypotension-in-elective-cesarean-delivery-does-preload-make-a-difference
#3
Brandi A Bottiger, Dmitri S Bezinover, Berend Mets, Priti G Dalal, Jansie Prozesky, Serdar Ural, Sonia Vaida
BACKGROUND AND AIMS: Patients undergoing elective cesarean delivery (CD) have a high-risk of spinal-induced hypotension (SIH). We hypothesized that a colloid preload would further reduce SIH when compared with a crystalloid preload. MATERIAL AND METHODS: Eighty-two healthy parturients undergoing elective CD were included in the study. Patients were randomly assigned to two groups (41 patients in each group) to receive either Lactated Ringer's solution (1500 ml) or hydroxyethyl starch (6% in normal saline, 500 ml) 30 min prior to placement of spinal anesthesia...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27546766/a-change-of-colloid-from-hydroxyethyl-starch-to-gelatin-does-not-reduce-rate-of-renal-failure-or-mortality-in-surgical-critical-care-patients-results-of-a-retrospective-cohort-study
#4
Frederic W Albrecht, Michael Glas, Hauke Rensing, Detlef Kindgen-Milles, Thomas Volk, Alexander M Mathes
PURPOSE: Hydroxyethyl starch (HES) may compromise renal function in critically ill patients. As an alternative, gelatin (GEL) was suggested. This study investigated whether GEL (4%) may have advantages over HES (6%, 130/0.4) with respect to acute renal failure (ARF), length of intensive care unit /hospital stay, and 30-day mortality and evaluated dose-dependent effects. MATERIAL AND METHODS: We performed a retrospective cohort analysis of 1522 surgical intensive care patients in a single university hospital where HES was changed to GEL in June 2006...
July 9, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27481739/how-safe-is-gelatin-a-systematic-review-and-meta-analysis-of-gelatin-containing-plasma-expanders-vs-crystalloids-and-albumin
#5
Claudia Moeller, Carolin Fleischmann, Daniel Thomas-Rueddel, Vlasislav Vlasakov, Bram Rochwerg, Philip Theurer, Luciano Gattinoni, Konrad Reinhart, Christiane S Hartog
Gelatin is a widely used synthetic colloid resuscitation fluid. We undertook a systematic review and meta-analysis of adverse effects in randomized and nonrandomized studies comparing gelatin with crystalloid or albumin for treatment of hypovolemia. Multiple databases were searched systematically without language restrictions until August 2015. We assessed risk of bias of individual studies and certainty in evidence assessment by the Grading of Recommendations Assessment, Development, and Evaluation approach...
October 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27113691/fluid-as-a-drug-balancing-resuscitation-and-fluid-overload-in-the-intensive-care-setting
#6
REVIEW
Matthew D McGuire, Michael Heung
Intravenous fluid resuscitation is ubiquitous throughout medicine and is often considered a benign procedure. Yet, there is now clear recognition of the potential harms of fluid overload after initial resuscitation. In recent years, there has also been an increasing focus on comparing various resuscitation fluids with respect to both benefits and risks. Studies have examined colloids, such as albumin and starches, against the clinical standard of crystalloids. In addition, evidence has emerged to suggest that outcomes may be different between resuscitation with chloride-rich vs balanced crystalloid solutions...
May 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/26976366/perioperative-fluid-volume-optimization-following-proximal-femoral-fracture
#7
REVIEW
Sharon R Lewis, Andrew R Butler, Andrew Brammar, Amanda Nicholson, Andrew F Smith
BACKGROUND: Proximal femoral fracture (PFF) is a common orthopaedic emergency that affects mainly elderly people at high risk of complications. Advanced methods for managing fluid therapy during treatment for PFF are available, but their role in reducing risk is unclear. OBJECTIVES: To compare the safety and effectiveness of the following methods of perioperative fluid optimization in adult participants undergoing surgical repair of hip fracture: advanced invasive haemodynamic monitoring, such as transoesophageal Doppler and pulse contour analysis; a protocol using standard measures, such as blood pressure, urine output and central venous pressure; and usual care...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26945358/impact-of-albumin-on-coagulation-competence-and-hemorrhage-during-major-surgery-a-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Kirsten C Rasmussen, Michael Højskov, Pär I Johansson, Irina Kridina, Thomas Kistorp, Lisbeth Salling, Henning B Nielsen, Birgitte Ruhnau, Tom Pedersen, Niels H Secher
For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n = 20) or LR (n = 20)...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26849439/differences-between-total-intravenous-anesthesia-and-inhalation-anesthesia-in-free-flap-surgery-of-head-and-neck-cancer
#9
Yi-Ting Chang, Chih-Chen Wu, Tsung-Yung Tang, Chun-Te Lu, Chih-Sheng Lai, Ching-Hui Shen
BACKGROUND: Many studies have evaluated risk factors associated with complications after free flap surgery, but these studies did not evaluate the impact of anesthesia management. The goal of the current study was to evaluate the differences between patients who received inhalation and total intravenous anesthesia (TIVA) in free flap surgery. METHODS: One hundred and fifty-six patients who underwent free flap surgery for head and neck cancer were retrospectively divided into the TIVA (96 patients) and the inhalation group (87 patients)...
2016: PloS One
https://www.readbyqxmd.com/read/26722660/perioperative-effects-of-high-doses-of-intraoperative-thymoglobulin-induction-in-liver-transplantation
#10
Lesley De Pietri, Valentina Serra, Giuseppe Preziosi, Gianluca Rompianesi, Bruno Begliomini
AIM: To describe our single-centre experience in liver transplantation (LT) with the infusion of high perioperative thymoglobulin doses. The optimal dosage and timing of thymoglobulin(®) [antithymocyte globulin (ATG)] administration during LT remains controversial. Cytokine release syndrome, haemolytic anaemia, thrombocytopenia, neutropenia, fever and serum sickness are potential adverse effects associated with ATG infusion. METHODS: Between December 2009 and December 2010, 16 adult non-randomized patients (ATG group), receiving a liver graft from a deceased donor, received an intraoperative infusion (4-6 h infusion) of thymoglobulin (3 mg/kg, ATG: Thymoglobuline(®))...
December 24, 2015: World Journal of Transplantation
https://www.readbyqxmd.com/read/26475802/effects-of-acute-plasma-volume-expansion-on-renal-perfusion-filtration-and-oxygenation-after-cardiac-surgery-a-randomized-study-on-crystalloid-vs-colloid
#11
RANDOMIZED CONTROLLED TRIAL
J Skytte Larsson, G Bragadottir, V Krumbholz, B Redfors, J Sellgren, S E Ricksten
BACKGROUND: In the present randomized study, we evaluated the differential effects of a colloid and a crystalloid fluid on renal oxygen delivery (RD(O2)), glomerular filtration (GFR), renal oxygen consumption ((RV(O2))), and the renal oxygen supply-demand relationship (i.e., renal oxygenation) after cardiac surgery with cardiopulmonary bypass. METHODS: Thirty patients with normal preoperative renal function, undergoing uncomplicated cardiac surgery, were studied in the intensive care unit in the early postoperative period...
November 2015: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/26445090/preferential-effects-of-low-volume-versus-high-volume-replacement-with-crystalloid-fluid-in-a-hemorrhagic-shock-model-in-pigs
#12
COMPARATIVE STUDY
Martin Ponschab, Herbert Schöchl, Claudia Keibl, Henrik Fischer, Heinz Redl, Christoph J Schlimp
BACKGROUND: Fluid resuscitation is a core stone of hemorrhagic shock therapy, and crystalloid fluids seem to be associated with lower mortality compared to colloids. However, as redistribution starts within minutes, it has been suggested to replace blood loss with a minimum of a three-fold amount of crystalloids. The hypothesis was that in comparison to high volume (HV), a lower crystalloid volume (LV) achieves a favorable coagulation profile and exerts sufficient haemodynamics in the acute phase of resuscitation...
2015: BMC Anesthesiology
https://www.readbyqxmd.com/read/26351826/comparison-of-hydroxyethyl-starch-colloids-with-crystalloids-for-surgical-patients-a-systematic-review-and-meta-analysis
#13
REVIEW
Mohamed Raiman, Colin G Mitchell, Bruce M Biccard, Reitze N Rodseth
BACKGROUND: Fluid therapy is one of the most ubiquitous medical therapeutic interventions. There is a debate over whether colloids or crystalloids are better for fluid resuscitation. Recent large trials and meta-analyses suggest no mortality benefit and possible harm with hydroxyethyl starch (HES) use. However, these trials were conducted in critically ill and septic patients and their applicability to perioperative patients has been challenged. OBJECTIVE: We aimed to evaluate the impact of HES use in scheduled and elective surgical patients...
January 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/26228998/bolus-intravenous-0-9-saline-but-not-4-albumin-or-5-glucose-causes-interstitial-pulmonary-edema-in-healthy-subjects
#14
RANDOMIZED CONTROLLED TRIAL
Shailesh Bihari, Ubbo F Wiersema, David Schembri, Carmine G De Pasquale, Dani-Louise Dixon, Shivesh Prakash, Mark D Lawrence, Jeffrey J Bowden, Andrew D Bersten
Rapid intravenous (iv) infusion of 0.9% saline alters respiratory mechanics in healthy subjects. However, the relative cardiovascular and respiratory effects of bolus iv crystalloid vs. colloid are unknown. Six healthy male volunteers were given 30 ml/kg iv 0.9% saline, 4% albumin, and 5% glucose at a rate of 100 ml/min on 3 separate days in a double-blinded, randomized crossover study. Impulse oscillometry, spirometry, lung volumes, diffusing capacity (DLCO), and blood samples were measured before and after fluid administration...
October 1, 2015: Journal of Applied Physiology
https://www.readbyqxmd.com/read/26220293/prehospital-use-of-plasma-in-traumatic-hemorrhage-the-pupth-trial-study-protocol-for-a-randomised-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Penny S Reynolds, Mary Jane Michael, Emily D Cochran, Jacob A Wegelin, Bruce D Spiess
BACKGROUND: Severe traumatic injury and haemorrhagic shock are frequently associated with disruptions of coagulation function (such as trauma-induced coagulopathy TIC) and activation of inflammatory cascades. These pathologies may be exacerbated by current standard of care resuscitation protocols. Observational studies suggest early administration of plasma to severely-injured haemorrhaging patients may correct TIC, minimise inflammation, and improve survival. The proposed randomised clinical trial will evaluate the clinical effectiveness of pre-hospital plasma administration compared with standard- of-care crystalloid resuscitation in severely-injured patients with major traumatic haemorrhage...
2015: Trials
https://www.readbyqxmd.com/read/26208230/two-doses-of-tranexamic-acid-reduce-blood-transfusion-in-complex-spine-surgery-a-prospective-randomized-study
#16
RANDOMIZED CONTROLLED TRIAL
Manee Raksakietisak, Benjabhorn Sathitkarnmanee, Peeranat Srisaen, Tithiganya Duangrat, Thitima Chinachoti, Pranee Rushatamukayanunt, Nuchanat Sakulpacharoen
STUDY DESIGN: Prospective, double-blinded, randomized controlled study. OBJECTIVE: To determine whether the use of 2 doses of tranexamic acid (TXA) can reduce perioperative blood loss and blood transfusions in low-risk adult patients undergoing complex laminectomy. SUMMARY OF BACKGROUND DATA: Complex laminectomy (multilevel laminectomy or laminectomy and instrumentation) is a procedure with a medium risk of blood loss, which may require allogeneic blood transfusion...
December 2015: Spine
https://www.readbyqxmd.com/read/26062689/a-randomized-controlled-trial-on-the-effects-of-goal-directed-therapy-on-the-inflammatory-response-open-abdominal-aortic-aneurysm-repair
#17
RANDOMIZED CONTROLLED TRIAL
Duane J Funk, Kent T HayGlass, Joshua Koulack, Greg Harding, April Boyd, Ryan Brinkman
INTRODUCTION: Goal-directed therapy (GDT) has been shown in numerous studies to decrease perioperative morbidity and mortality. The mechanism of benefit of GDT, however, has not been clearly elucidated. Targeted resuscitation of the vascular endothelium with GDT might alter the postoperative inflammatory response and be responsible for the decreased complications with this therapy. METHODS: This trial was registered at ClinicalTrials.gov as NCT01681251. Forty patients undergoing elective open repair of their abdominal aortic aneurysm, 18 years of age and older, were randomized to an interventional arm with GDT targeting stroke volume variation with an arterial pulse contour cardiac output monitor, or control, where fluid therapy was administered at the discretion of the attending anesthesiologist...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26041437/continuous-central-venous-oxygen-saturation-assisted-intraoperative-hemodynamic-management-during-major-abdominal-surgery-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
András Mikor, Domonkos Trásy, Márton F Németh, Angelika Osztroluczki, Szilvia Kocsi, Ildikó Kovács, Gábor Demeter, Zsolt Molnár
BACKGROUND: Major abdominal surgery is associated with significant risk of morbidity and mortality in the perioperative period. Optimising intraoperative fluid administration may result in improved outcomes. Our aim was to compare the effects of central venous pressure (CVP), and central venous oxygen saturation (ScvO2)-assisted fluid therapy on postoperative complications in patients undergoing high risk surgery. METHODS: Patients undergoing elective major abdominal surgery were randomised into control and ScvO2 groups...
2015: BMC Anesthesiology
https://www.readbyqxmd.com/read/25805553/identifying-patients-at-risk-for-high-grade-intra-abdominal-hypertension-following-trauma-laparotomy
#19
COMPARATIVE STUDY
Steven G Strang, Diederik L Van Imhoff, Esther M M Van Lieshout, Scott K D'Amours, Oscar J F Van Waes
BACKGROUND: Abdominal Compartment Syndrome (ACS) is an uncommon but deleterious complication after trauma laparotomy. Early recognition of patients at risk of developing ACS is crucial for their outcome. The aim of this study was to compare the characteristics of patients who developed high-grade intra-abdominal hypertension (IAH) (i.e., grade III or IV; intra-abdominal pressure, IAP >20 mm Hg) following an injury-related laparotomy versus those who did not (i.e., IAP ≤20 mm Hg)...
May 2015: Injury
https://www.readbyqxmd.com/read/25782071/renal-haemodynamic-response-to-amino-acids-infusion-in-an-experimental-porcine-model-of-septic-shock
#20
O Vassal, J-M Bonnet, A Barthelemy, B Allaouchiche, I Goy-Thollot, V Louzier, C Paquet, J-Y Ayoub, O Dauwalder, M Jacquet-Lagrèze, S Junot
BACKGROUND: Acute kidney injury (AKI) is common in sepsis. Treatments allowing maintenance of renal blood flow (RBF) could help to prevent AKI associated with renal hypoperfusion. Amino acids (AA) have been associated with an increase of RBF and glomerular filtration rate (GFR) in several species. The aim of this study was to evaluate the effects of an AA infusion on RBF and GFR in a porcine model of septic shock. METHODS: A total of 17 piglets were randomly assigned into three groups: Sham (Sham, n = 5), sepsis without AA (S-NAA, n = 6), sepsis treated with AA (S-AA, n = 6)...
May 2015: Acta Anaesthesiologica Scandinavica
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