keyword
https://read.qxmd.com/read/38537149/urinary-bladder-involvement-in-igg4-related-disease-a-case-based-review
#1
JOURNAL ARTICLE
Parag Vijayvergia, Sayan Mukherjee, Lily Singh, Urmila Dhakad
Immunoglobulin G4-related disease (IgG4-RD) is an immune-driven fibroinflammatory disease that presents as tumefactive lesions that not only commonly affects the pancreas, lacrimal and salivary glands, lung, liver and kidney but can also affect any organs. However, involvement of the urinary bladder in IgG4-RD is rarely reported. We describe a case of IgG4-RD involving the urinary bladder mimicking carcinoma and review the published literature-a 39-year-old male presented with complaints of dysuria, urgency and hesitancy...
March 2, 2024: Modern rheumatology case reports
https://read.qxmd.com/read/38537009/transient-receptor-potential-melastatin-7-trpm7-ion-channel-inhibitors-preliminary-sar-and-conformational-studies-of-xenicane-diterpenoids-from-the-hawaiian-soft-coral-sarcothelia-edmondsoni
#2
JOURNAL ARTICLE
Guangmin Yao, Matthew R Parris, W Cedric Kuo, Peter Pörzgen, Brandi Castillo, Evan S Mason, Andres Chinchilla, Junhao Huang, Sayuri Suzuki, Rylee Ross, Ellis Akana, Savana Vander Schuit, Steven P Miller, Reinhold Penner, Hong-Shuo Sun, Zhong-Ping Feng, Kenneth G Hull, Daniel Romo, Andrea Fleig, F David Horgen
Waixenicin A, a xenicane diterpene from the octocoral Sarcothelia edmondsoni , is a selective, potent inhibitor of the TRPM7 ion channel. To study the structure-activity relationship (SAR) of waixenicin A, we isolated and assayed related diterpenes from S. edmondsoni . In addition to known waixenicins A ( 1 ) and B ( 2 ), we purified six xenicane diterpenes, 7 S ,8 S -epoxywaixenicins A ( 3 ) and B ( 4 ), 12-deacetylwaixenicin A ( 5 ), waixenicin E ( 6 ), waixenicin F ( 7 ), and 20-acetoxyxeniafaraunol B ( 8 )...
March 27, 2024: Journal of Natural Products
https://read.qxmd.com/read/38536801/using-texture-analysis-of-ultrasound-images-to-assess-the-effect-of-cupping-therapy-on-muscle-quality-of-the-triceps
#3
JOURNAL ARTICLE
Isabella Yu-Ju Hung, Yih-Kuen Jan
The objectives were to investigate whether cupping therapy improves muscle quality and the interaction between duration and negative pressure of cupping therapy affects muscle quality. A 2×2 factorial design with repeated measures was used to examine the efficacy of cupping therapy on improving muscle quality. The independent factors were cupping pressures at -225 and -300 mmHg and cupping durations at 5 and 10 min, and the dependent factor was texture of B-mode ultrasound image of the triceps. Four cupping protocols were applied to 12 participants at 4 different days...
2024: PloS One
https://read.qxmd.com/read/38536540/palbociclib-inhibits-the-progression-of-head-and-neck-cancer-and-improves-the-cetuximab-response-under-specific-condition-in-vitro-and-in-vivo
#4
JOURNAL ARTICLE
Ruichen Li, Qi Wang, Yang Zhao, Yi Zhu, Xiaoshen Wang
BACKGROUND: In head and neck squamous cell carcinoma (HNSCC) with human papillomavirus (HPV)-negative, deregulation of cell cycle is partly due to inactivation of p16INK4 and overexpression of cyclin D1. Here we investigated the in vitro and in vivo effects of the CDK4/6 inhibitor Palbociclib alone or combined with EGFR inhibitor Cetuximab in HNSCC. METHODS AND RESULTS: CCK-8, soft agar assay, colony formation assay, wound healing assay and transwell assay, β-galactosidase assay, western blotting, and cell-derived xenografts were used to investigated the in vitro and in vivo activity of drugs...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536486/technology-and-the-situationist-challenge-to-virtue-ethics
#5
JOURNAL ARTICLE
Fabio Tollon
In this paper, I introduce a "promises and perils" framework for understanding the "soft" impacts of emerging technology, and argue for a eudaimonic conception of well-being. This eudaimonic conception of well-being, however, presupposes that we have something like stable character traits. I therefore defend this view from the "situationist challenge" and show that instead of viewing this challenge as a threat to well-being, we can incorporate it into how we think about living well with technology. Human beings are susceptible to situational influences and are often unaware of the ways that their social and technological environment influence not only their ability to do well, but even their ability to know whether they are doing well...
March 27, 2024: Science and Engineering Ethics
https://read.qxmd.com/read/38536461/esr-essentials-mri-of-the-knee-practice-recommendations-by-essr
#6
REVIEW
Anagha P Parkar, Miraude E A P M Adriaensen
Many studies and systematic reviews have been published about MRI of the knee and its structures, discussing detailed anatomy, imaging findings, and correlations between imaging and clinical findings. This paper includes evidence-based recommendations for a general radiologist regarding choice of imaging sequences and reporting basic MRI examinations of the knee. We recommend using clinicians' terminology when it is applicable to the imaging findings, for example, when reporting meniscal, ligament and tendon, or cartilage pathology...
March 27, 2024: European Radiology
https://read.qxmd.com/read/38536453/braiding-twisting-and-weaving-microscale-fibers-with-capillary-forces
#7
JOURNAL ARTICLE
Ahmed Sherif, Maya Winters Faaborg, Cheng Zeng, Michael P Brenner, Vinothan N Manoharan
Soft materials made from braided or woven microscale fibers can display unique properties that can be exploited in electromagnetic, mechanical, and biomedical applications. These properties depend on the topology of the braids or weaves-that is, the order in which fibers cross one another. Current industrial braiding and weaving machines cannot easily braid or weave micrometer-scale fibers into controllable topologies; they typically apply forces that are large enough to break the fibers, and each machine can typically make only one topology...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38536429/double-chin-concerns-after%C3%A2-en-bloc-mandibular-u-shaped%C3%A2-osteotomy-submental-cervical-soft-tissue-changes-and-anterior-belly-of-digastric-muscle-assessment
#8
JOURNAL ARTICLE
Yingying Yue, Xiaoshuang Guo, Chenzhi Lai, Xiaolei Jin
OBJECTIVE: To assess submental-cervical soft tissue changes after en bloc mandibular U-shaped osteotomy and examine alterations in the anterior belly of digastric muscle (ABDM). METHODS: A retrospective study analyzed 20 patients who underwent en bloc mandibular U-shaped osteotomy from 2018 to 2023. Preoperative (Tp) and long-term follow-up (Tf) CT data were collected for analysis, measuring mandibular volume, soft tissue thickness at menton (Mes) and cervicale (C), and ABDM parameters (length, cross-sectional area (CSA), volume, distance from centroid point to the mandibular margin)...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536237/ion-solvent-interactions-under-confinement-hold-the-key-to-tuning-the-dna-translocation-speeds-in-polyelectrolyte-functionalized-nanopores
#9
JOURNAL ARTICLE
Avinash Kumar, Chirodeep Bakli, Suman Chakraborty
DNA sequencing and sensing using nanopore technology delves critically into the alterations in the measurable electrical signal as single-stranded DNA is drawn through a tiny passage. To make such precise measurements, however, slowing down the DNA in the tightly confined passage is a key requirement, which may be achieved by grafting the nanopore walls with a polyelectrolyte layer (PEL). This soft functional layer at the wall, under an off-design condition, however, may block the DNA passage completely, leading to the complete loss of output signal from the nanobio sensor...
March 27, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38536224/cosolvent-incorporation-modulates-the-thermal-and-structural-response-of-pnipam-silyl-methacrylate-copolymers
#10
JOURNAL ARTICLE
Jason D Linn, Fabian A Rodriguez, Michelle A Calabrese
Polymers functionalized with inorganic silane groups have been used in wide-ranging applications due to the silane reactivity, which enables formation of covalently-crosslinked polymeric structures. Utilizing stimuli-responsive polymers in these hybrid systems can lead to smart and tunable behavior for sensing, drug delivery, and optical coatings. Previously, the thermoresponsive polymer poly( N -isopropyl acrylamide) (PNIPAM) functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMA) demonstrated unique aqueous self-assembly and optical responses following temperature elevation...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38536133/superficial-acral-fibromyxoma-on-the-thumb-nail-bed
#11
JOURNAL ARTICLE
Kyra Diehl, Cara Barber, Oliver J Wisco, John Young, Sandra Osswald, Lisa Cohen
Superficial acral fibromyxoma, also known as digital fibromyxoma, is a benign soft tissue tumor. The acral regions, including the palms, soles, fingers, toes, and nail units, are the commonly affected locations. The subungual region of the great toe is the most common site reported in current literature. The tumor is slowly progressive and benign in nature. Histology commonly reveals a fibromyxoid neoplasm with immunoreactivity to CD34 and CD99 markers.1,2,3 We present the case of a 39-year-old female with a nine-year history of repetitive digital trauma presenting with superficial acral fibromyxoma of the thumb-nail bed...
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38536072/pure-elongation-flow-of-an-electrorheological-fluid-insights-on-wall-slip-from-electrorheology
#12
JOURNAL ARTICLE
Ishu Chaudhary, Manish Kaushal
In this work we study the pure elongation flow behavior of an electrorheological (ER) fluid as a model soft-jammed system, wherein the extent of jamming is controlled by an externally applied electric-field. More specifically, a pure elongation flow has been achieved by facilitating significant slip at the contact between the material and rheometer-plate while pulling it with constant pulling velocity under a constant external electric-field. The normal force exerted by the top plate on the material was measured as a function of gap during the flow for various combinations of electric-field strength and pulling velocity...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38536068/best-overall-response-associated-signature-to-doxorubicin-in-soft-tissue-sarcomas-a-transcriptomic-analysis-from-announce
#13
JOURNAL ARTICLE
Jiangang Liu, David S Moura, Robin L Jones, Amit Aggarwal, Ebert J Philip, Andrew J Wagner, Jennifer Wright, Javier Martín-Broto, William D Tap
PURPOSE: This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase-3 ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas (STS) and to potentially identify its predictive markers. EXPERIMENTAL DESIGN: RNA sequencing was performed on pretreatment tumor samples (n=273) from the ANNOUNCE trial to evaluate response patterns and identify potential predictive treatment markers for doxorubicin...
March 27, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38536066/hydrodynamically-induced-aggregation-of-two-dimensional-oriented-active-particles
#14
JOURNAL ARTICLE
Roee Bashan, Naomi Oppenheimer
We investigate a system of co-oriented active particles interacting only via hydrodynamic and steric interactions in a two-dimensional fluid. We offer a new method of calculating the flow created by any active particle in such a fluid, focusing on the dynamics of flow fields with a high-order spatial decay, which we analyze using a geometric Hamiltonian. We show that when the particles are oriented and the flow has a single, odd power decay, such systems lead to stable, fractal-like aggregation, with the only exception being the force dipole...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38535973/-pseudomonas-stutzeri-bloodstream-infection-is-a-prevailing-community-onset-disease-with-important-mortality-rates-results-from-a-retrospective-observational-study-in-australia
#15
JOURNAL ARTICLE
Juan P Horcajada, Felicity Edwards, Silvia Fonio, Milagro Montero, Patrick Harris, David L Paterson, Kevin B Laupland
BACKGROUND: The recognition of Pseudomonas stutzer i as a cause of infections in humans has been increasing. However, only case reports and small series of P. stutzeri bloodstream infections have been published. Epidemiological data on these infections are extremely scarce. Our objective was to describe the incidence, epidemiology, antimicrobial resistance rates, and outcomes of P. stutzeri bloodstream infections in a large population-based cohort in Australia. METHODS: Retrospective, laboratory-based surveillance study conducted in Queensland, Australia (population ≈ 5 million) during 2000-2019...
March 27, 2024: Infectious Diseases
https://read.qxmd.com/read/38535856/establishment-and-application-prospect-of-reverse-transcriptase-recombinase-aided-amplification-assay-for-subgroup-c-avian-metapneumovirus
#16
JOURNAL ARTICLE
Yuhang Bai, Xiuhong Wu, Jiajia Liu, Zhanxin Wang, Mengyue Dong, Tong Li, Zhenkai Dai, Hongxin Li, Qingmei Xie, Xinheng Zhang
Among broilers, the main pathogen that leads to swollen head syndrome (SHS) is the subgroup C avian metapneumovirus (aMPV-C). The aMPV-C infection can lead to an upsurge in the rate of soft-shell eggs, resulting in reduced egg production and seriously affecting the economy of the livestock industry. Therefore, a rapid method for aMPV-C detection needs to be invented. According to the N gene of aMPV-C, we designed the specific probe and primer and created a reverse transcription recombinase-aided amplification assay (RT-RAA) for the detection of aMPV-C...
March 7, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535837/exploring-the-effectiveness-of-problem-based-learning-in-an-international-undergraduate-program-in-veterinary-sciences-students-satisfaction-experience-and-learning
#17
JOURNAL ARTICLE
Anna Broseghini, Miina Lõoke, Marta Brscic, Juliana Raffaghelli, Barbara Cardazzo, Antonella Lotti, Laura Cavicchioli, Lieta Marinelli
The systematic evaluation of the integration of problem-based learning (PBL) into educational programs in Italy is scarce and there are no published reports of its use in an Italian Bachelor of Veterinary Science degree program. This paper aims to assess the satisfaction of second-year students on an international Bachelor of Veterinary Science degree program after implementing two weeks of PBL with a multidisciplinary approach. Moreover, the impact of this methodological approach on the students' performance and their perceptions concerning their learning experience was investigated...
February 27, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535705/liquid-metal-enabled-epidermal-interfaces
#18
REVIEW
Ting Fang, Yuping Sun, Desheng Kong
Soft materials are crucial for epidermal interfaces in biomedical devices due to their capability to conform to the body compared to rigid inorganic materials. Gels, liquids, and polymers have been extensively explored, but they lack sufficient electrical and thermal conductivity required for many application settings. Gallium-based alloys are molten metals at room temperature with exceptional electrical and thermal conductivity. These liquid metals and their composites can be directly applied onto the skin as interface materials...
March 27, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38535667/strategic-structural-control-of-polyserotonin-nanoparticles-and-their-application-as-ph-responsive-nanomotors
#19
JOURNAL ARTICLE
Junyi Hu, Jingjing Cao, Jinwei Lin, Leilei Xu
Serotonin-based nanomaterials have been positioned as promising contenders for constructing multifunctional biomedical nanoplatforms due to notable biocompatibility, advantageous charge properties, and chemical adaptability. The elaborately designed structure and morphology are significant for their applications as functional carriers. In this study, we fabricated anisotropic bowl-like mesoporous polyserotonin (PST) nanoparticles with a diameter of approximately 170 nm through nano-emulsion polymerization, employing P123/F127 as a dual-soft template and 1,3,5-trimethylbenzene (TMB) as both pore expander and emulsion template...
March 14, 2024: Nanomaterials
https://read.qxmd.com/read/38535456/jasmonates-and-ethylene-shape-floridoside-synthesis-during-carposporogenesis-in-the-red-seaweed-grateloupia-imbricata
#20
JOURNAL ARTICLE
Pilar Garcia-Jimenez, Diana Del Rosario-Santana, Rafael R Robaina
Floridoside is a galactosyl-glycerol compound that acts to supply UDP-galactose and functions as an organic osmolyte in response to salinity in Rhodophyta. Significantly, the UDP-galactose pool is shared for sulfated cell wall galactan synthesis, and, in turn, affected by thallus development alongside carposporogenesis induced by volatile growth regulators, such as ethylene and methyl jasmonate, in the red seaweed Grateloupia imbricata . In this study, we monitored changes in the floridoside reservoir through gene expression controlling both the galactose pool and glyceride pool under different reproductive stages of G...
February 28, 2024: Marine Drugs
keyword
keyword
1162
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.