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https://www.readbyqxmd.com/read/29156834/oncolytic-reovirus-inhibits-angiogenesis-through-induction-of-cxcl10-ip-10-and-abrogation-of-hif-activity-in-soft-tissue-sarcomas
#1
Jennifer S Carew, Claudia M Espitia, Weiguo Zhao, Monica M Mita, Alain C Mita, Steffan T Nawrocki
The tumor-selective viral replication capacity and pro-apoptotic effects of oncolytic reovirus have been reported to be dependent on the presence of an activated RAS pathway in several solid tumor types. However, the mechanisms of selective anticancer efficacy of the reovirus-based formulation for cancer therapy (Reolysin, pelareorep) have not been rigorously studied in soft tissue sarcomas (STS). Here we report that Reolysin triggered a striking induction of the anti-angiogenic chemokine interferon-γ-inducible protein 10 (IP-10)/CXCL10 (CXC chemokine ligand 10) in both wild type and RAS mutant STS cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156703/preclinical-efficacy-of-the-novel-competitive-nampt-inhibitor-stf-118804-in-pancreatic-cancer
#2
Jair Machado Espindola-Netto, Claudia C S Chini, Mariana Tarragó, Enfeng Wang, Shamit Dutta, Krishnendu Pal, Debabrata Mukhopadhyay, Mauro Sola-Penna, Eduardo N Chini
NAD salvage is one of the pathways used to generate NAD in mammals. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in this pathway, uses nicotinamide (NAM) to generate nicotinamide mononucleotide (NMN). NMN is one of the main precursors of NAD synthesis in cells. Our previous study showed the importance of NAMPT in maintaining NAD levels in pancreatic ductal adenocarcinoma cells (PDAC), and that the NAMPT inhibitor FK866 decreased pancreatic cancer growth. We now tested the effect of STF-118804, a new highly specific NAMPT inhibitor, in models of pancreatic ductal adenocarcinoma...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156641/facile-control-of-the-porous-structure-of-larch-derived-mesoporous-carbons-via-self-assembly-for-supercapacitors
#3
Xin Zhao, Wei Li, Honglei Chen, Shoujuan Wang, Fangong Kong, Shouxin Liu
Mesoporous carbons have been successfully synthesized via self-assembly using larch-based resins as precursors and triblock copolymers as soft templates. The porous structure of mesoporous carbons can be tailored by adjusting the ratio of hydrophilic/hydrophobic (EO/PO) units owing to interfacial curvature. Interestingly, the porous structures show a distinct change from vortex-like to worm-like pores, to stripe-like pores, and to ordered two-dimensional hexagonal pores as the ratio of hydrophilic/hydrophobic units increases, indicating the significant effect of EO/PO ratio on the porous structure...
November 20, 2017: Materials
https://www.readbyqxmd.com/read/29156561/adsorptive-stripping-voltammetric-determination-of-amaranth-and-tartrazine-in-drinks-and-gelatins-using-a-screen-printed-carbon-electrode
#4
Yeny Perdomo, Verónica Arancibia, Olimpo García-Beltrán, Edgar Nagles
A fast, sensitive, and selective method for the simultaneous determination of one pair of synthetic colorants commonly found mixed in food products, Amaranth (AM) and Tartrazine (TZ), based on their adsorption and oxidation on a screen-printed electrode (SPE) is presented. The variation of peak current with pH, supporting electrolyte, adsorption time, and adsorption potential were optimized using square wave adsorptive voltammetry. The optimal conditions were found to be: pH 3.2 (PBS), Eads 0.00 V, and tads 30 s...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156453/use-of-genetic-testing-after-abnormal-screening-ultrasound-a-descriptive-cohort-study
#5
Alessandra J Ainsworth, Michelle A Holman, Elisabeth Codsi, Myra Wick
BACKGROUND/AIMS: The study aimed to characterize the use of genetic testing after abnormal screening ultrasound. METHODS: We performed a retrospective review of patients undergoing genetic testing after abnormal ultrasound. Genetic evaluation consisted of noninvasive prenatal screening (NIPS) or amniocentesis. Classification of ultrasound findings, type of genetic testing, and results were collected. RESULTS: A total of 139 subjects underwent genetic evaluation after abnormal screening ultrasound...
November 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29156171/the-use-of-decellularized-human-placenta-in-full-thickness-wound-repair-and%C3%A2-periarticular-soft-tissue-reconstruction-an-update-on-regenerative-healing
#6
REVIEW
Stephen A Brigido, Scott C Carrington, Nicole M Protzman
Prolonged or incomplete healing of the foot and ankle can pose significant challenges. Therefore, investigators have begun searching for alternative treatment strategies. With advances in tissue engineering, decellularized human placental connective tissue matrix has been suggested as a means to achieve more rapid and complete healing for various soft tissue and bone procedures. Basic science and clinical studies have shown that decellularized human placental connective tissue matrix can support regenerative healing through cellular migration, accelerated tissue remodeling, and the establishment of functional tissue...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29155964/effects-of-replacing-soybean-meal-with-chickpea-seeds-in-the-diet-on-mechanical-and-thermal-properties-of-tendon-tissue-in-broiler-chicken
#7
S Muszynski, M Kwiecien, M Swietlicki, P Dobrowolski, J Tatarczak, B Gladyszewska
The efficiency of the musculoskeletal system of broiler chickens, in particular during locomotion and in ensuring its supportive function, depends directly on the adequate function and mechanical endurance of soft tissues, including tendons. However, little is known whether the properties of musculoskeletal soft tissues can be influenced by changes of dietary protein. We substituted soybean meal with raw chickpea seeds as the primary protein source in the diet and studied the effects it had on the mechanical and thermal properties of drumstick tendons in broiler Ross 308 chickens...
November 15, 2017: Poultry Science
https://www.readbyqxmd.com/read/29155710/dna-nanotubes-as-a-versatile-tool-to-study-semiflexible-polymers
#8
Jörg Schnauß, Martin Glaser, Jessica S Lorenz, Carsten Schuldt, Christin Möser, Martin Sajfutdinow, Tina Händler, Josef A Käs, David M Smith
Mechanical properties of complex, polymer-based soft matter, such as cells or biopolymer networks, can be understood in neither the classical frame of flexible polymers nor of rigid rods. Underlying filaments remain outstretched due to their non-vanishing backbone stiffness, which is quantified via the persistence length (lp), but they are also subject to strong thermal fluctuations. Their finite bending stiffness leads to unique, non-trivial collective mechanics of bulk networks, enabling the formation of stable scaffolds at low volume fractions while providing large mesh sizes...
October 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155560/asymmetric-assembling-of-iron-oxide-nanocubes-for-improving-magnetic-hyperthermia-performance
#9
Dina Niculaes, Aidin Lak, George C Anyfantis, Sergio Marras, Oliver Laslett, Sahitya K Avugadda, Marco Cassani, David Serantes, Ondrej Hovorka, Roy Chantrell, Teresa Pellegrino
agnetic hyperthermia (MH) based on magnetic nanoparticles (MNPs) is a promising adjuvant therapy for cancer treatment. Particle clustering leading to complex magnetic interactions affects the heat generated by MNPs during MH. The heat efficiencies, theoretically predicted, are still poorly understood because of lack of the control of the fabrication of such clusters with defined geometries and thus their functionality. This study aims to correlate the heating efficiency under MH of individually coated iron oxide nanocubes (IONCs) vs...
November 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29154856/comparative-study-of-two-immunity-related-gtpase-genes-in-chinese-soft-shell-turtle-reveals-their-molecular-characteristics-and-functional-activity-in-immune-defense
#10
Yan Shi, Sixian Shen, Sufei Hu, Tie Ding, Xiaoyou Hong, Chen Chen, Xinping Zhu, Zhe Zhao
The immunity-related GTPases (IRGs) are a family of proteins that play critical roles in innate resistance to intracellular pathogens. The number and diversity of IRG genes differ greatly in different species. Although IRG proteins have been well studies in mammals, they remain poorly characterized in lower vertebrates. In this study, we cloned two IRG genes, PsIRG5 and PsIRG8, from the Chinese soft-shelled turtle and compared their characterization and functional activity with mammalian IRGs. The PsIRG5 is a gene of 1896 bp that encodes a protein of 413 amino acid and PsIRG8 is 1543 bp in length encoding another 413 aa protein...
November 14, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29154803/new-scale-down-methodology-from-commercial-to-lab-scale-to-optimize-plant-derived-soft-gel-capsule-formulations-on-a-commercial-scale
#11
Sana Oishi, Shin-Ichiro Kimura, Shuji Noguchi, Mio Kondo, Yosuke Kondo, Yoshiyuki Shimokawa, Yasunori Iwao, Shigeru Itai
A new scale-down methodology from commercial rotary die scale to laboratory scale was developed to optimize a plant-derived soft gel capsule formulation and eventually manufacture superior soft gel capsules on a commercial scale, in order to reduce the time and cost for formulation development. Animal-derived and plant-derived soft gel film sheets were prepared using an applicator on a laboratory scale and their physicochemical properties, such as tensile strength, Young's modulus, and adhesive strength, were evaluated...
November 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29154746/in-vitro-and-in-vivo-activity-of-fosfomycin-alone-and-in-combination-with-rifampin-and-tigecycline-against-gram-positive-cocci-isolated-from-surgical-wound-infections
#12
Oriana Simonetti, Gianluca Morroni, Roberto Ghiselli, Fiorenza Orlando, Andrea Brenciani, Ledia Xhuvelaj, Mauro Provinciali, Annamaria Offidani, Mario Guerrieri, Andrea Giacometti, Oscar Cirioni
Complicated skin and soft tissue infections constitute a heterogeneous group of severe disorders, with surgical site infections being the most common hospital-acquired ones. The aim of our study was to investigate the synergistic and bactericidal activities of antimicrobial combinations of fosfomycin with rifampicin and tigecycline against Enterococcus faecalis, Enterococcus faecium and methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, and also to evaluate their in vivo effects in a mouse wound infection model...
November 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29154693/epidemiology-of-injury-due-to-race-day-jockey-falls-in-professional-flat-and-jump-horse-racing-in-ireland-2011-2015
#13
Siobhan O'Connor, Giles Warrington, Adrian McGoldrick, SarahJane Cullen
CONTEXT:   Professional horse racing is considered a high-risk sport, yet the last analysis of fall and injury incidence in this sport in Ireland was completed between 1999 and 2006. OBJECTIVE:   To provide an updated analysis of the fall and injury incidence in professional flat and jump horse racing in Ireland from 2011 through 2015, compare it with the previous analysis, and detail the specific types and locations of injuries. DESIGN:   Descriptive epidemiology study...
November 20, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29154457/complications-from-microfocused-transcutaneous-ultrasound-case-series-and-review-of-the-literature
#14
Daniel P Friedmann, Gregory P Bourgeois, Henry H L Chan, Ann C Zedlitz, Kimberly J Butterwick
BACKGROUND AND OBJECTIVE: Microfocused ultrasound (MFUS) technology has been utilized since 2009 for improvement in mild to moderate skin and soft tissue laxity of the face and neck. Few complications have been previously reported, the majority of which include mild and transient erythema, edema, ecchymosis, and nerve paralysis. Rare yet serious potential complications of MFUS for noninvasive skin tightening of the face and neck are, however, possible. METHODS & MATERIALS: Retrospective multicenter case series of five patients from the authors' practice who developed serious adverse events directly related to MFUS with a commercially available device (Ultherapy; Merz North America, Inc...
November 20, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29154403/paleo-inspired-systems-durability-sustainability-and-remarkable-properties
#15
Loïc Bertrand, Claire Gervais, Admir Masic, Luc Robbiola
We designate as paleo-inspiration, the process of mimicking properties of specific interest (mechanical, optical, structural, etc.) observed in ancient and historical systems. For instance, recovery in archaeology or paleontology identifies materials that are a posteriori extremely resilient to alteration. This is all the more enthusing that many ancient materials were synthesized in soft chemical ways, often using low energy resources, and sometimes rudimentary manufacturing equipment. In this review, we highlight ancient systems as a source of inspiration for innovative conception in the Anthropocene...
November 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29154300/fracture-generation-in-human-vertebrae-under-compression-loading-the-influence-of-pedicle-preservation-and-bone-mineral-density-on-in-vitro-fracture-behavior
#16
Michael Kraxenberger, Christian Schröder, Tobias Geith, Andreas Büttner, Christoph von SchulzePeelengahr, Christof Birkenmaier, Peter Muller, Volkmar Jansson, Bernd Wegener
BACKGROUND: Fractured vertebral bodies are a common and wide spread health issue. OBJECTIVE: The purpose of this study was to develop a standardized method to experimentally generate compression fractures in vertebral bodies. The influence of the pedicles has been investigated with regards to the fracture behavior. The correlation between bone mineral density (BMD), the cause of fractures and the fracture behavior was investigated. METHODS: Twenty-one fresh frozen human lumbar spines were examined for bone mineral density (BMD) by means of quantitative computed tomography (qCT)...
November 10, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29154264/the-effect-of-a-single-massage-based-on-the-tensegrity-principle-on-postural-stability-in-young-women
#17
Błażej Cieślik, Ireneusz Podsiadły, Michał Kuczyński, Bożena Ostrowska
OBJECTIVE: The aim of this study was to investigate the effects of normalized muscle tension via tensegrity-based massage on postural stability in a sample of female young adults. METHODS: Nineteen females aged 21.8 ± 1.9 years were recruited presenting abnormal tension at muscles adhering to any of the following structural sites: superior iliac spine, lateral sacropelvic surface, linea aspera at 1/2 of femur length, and superior nuchal line of the occiput. Balance and postural control were assessed during bipedal stance using a force platform in multiple conditions: hard surface or soft foam surface with the head in either a neutral posture or tilted backward...
November 6, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29154099/comparison-analysis-on-the-thermal-runaway-of-lithium-ion-battery-under-two-heating-modes
#18
Tangqin Wu, Haodong Chen, Qingsong Wang, Jinhua Sun
The thermal stability evaluation of materials in a soft-pack commercial cell is tested using C80 calorimeter, including anode, cathode, separator and full cell (mixing of the three materials including additional electrolyte). Thermal runaway characteristic of the commercial cell is tested on the accelerating rate calorimeter (ARC) with two heating modes, including internal heating mode and external heating mode. The results show that the thermal stability of internal material for tested cell follows the below order: anode<separator<cathode...
November 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29153918/nursing-music-protocol-and-postoperative-pain
#19
REVIEW
Michael J Poulsen, Jeffrey Coto
Pain has always been a major concern for patients and nurses during the postoperative period. Therapies, medicines, and protocols have been developed to improve pain and anxiety but have undesirable risks to the patient. Complementary and alternative medicine therapies have been studied but have not been applied as regular protocols in the hospital setting. Music is one type of complementary and alternative medicine therapy that has been reported to have favorable results on reducing postoperative pain, anxiety, and opioid usage...
November 16, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29153869/-benign-tumors-of-the-soft-tissue-of-the-hand-about-70%C3%A2-cases
#20
M Khezami, H Bellaaj, A Abdennadher, K Amri, M Hamdi, L Nouisri
Through a retrospective study of 70 cases of benign soft tissue tumors in the orthopedic traumatology department of the military hospital of Tunis over a 12-year period from January 2005 to December 2016, we have compared our findings to those of the literature in an attempt to identify epidemiological notions relevant to daily medical practice as epidemiological data on benign tumors of the soft parts of the hand remain few and sometimes discordant. The authors report a series of 70 active, young adults, mostly female, with a swelling at the level of the hand as the most common reason for consultation...
November 16, 2017: Annales de Chirurgie Plastique et Esthétique
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